TY - JOUR. T1 - Paraneoplastic cerebellar degeneration associated with ovarian cancer. AU - Russo, Alessia Erika. AU - Scalone, Simona. AU - Leonardi, Giulia Costanza. AU - Scalisi, Aurora. AU - Giorda, Giorgio. AU - Sorio, Roberto. PY - 2013/2. Y1 - 2013/2. N2 - Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. PCD often precedes the cancer diagnosis by months to years. Here, we report the case of a 64-year-old woman who developed PCD symptoms, associated with high levels of anti-Yo antibodies, one year after a previous diagnosis of ovarian cancer. Clinical features, pathogenesis and treatment of PCD associated with cancer are discussed according to previous studies.. AB - Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. PCD ...
The prevalence of paraneoplastic cerebellar degeneration (PCD) associated with gynecological cancer is rare. Here, we reported the first case of ovarian cancer revealed by PCD in our institute. we describe a 80- year old Moroccan female presented with subacute vestibular and cerebellar syndromes, she had an inguinal lymphadenopathy,with high levels of Anti-YO. Rapid progression and absence of known etiologies point towards a probable paraneoplastic origin of the syndrome in this patient. The exact incidence of PNS among those diagnosed with cancer remains uncertain, it is important to report this cases in the literature to help early diagnosis and appropriate treatment, which are able to stabilize the neurological symptoms.
Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome associated with a broad variety of tumors including lung cancer, ovarian cancer, breast cancer, Hodgkins lymphoma and others. PCD is a rare condition that occurs in less than 1% of cancer patients. As is the case with other paraneoplastic syndromes, PCD is believed to be due to an autoimmune reaction targeted against components of the central nervous system, mostly to Purkinje cells. It is thought to be triggered when tumor cells (in PCD, most commonly ovarian or breast cancer) ectopically express proteins normally expressed in the cerebellum. This is believed to trigger an anti-tumor immune response that may be clinically significant, but also an anti-neural immune response. A broad spectrum of neuronal and glial proteins has been identified as target antigens in PCD. Neurological symptoms may include, among others, dysarthria, truncal, limb and gait ataxia and nystagmus. Symptoms often develop subacutely and progress ...
Raised levels of P/Q type voltage-gated calcium-channel (VGCC) antibodies were found in 16 (41%) of 39 patients with paraneoplastic cerebellar degeneration (PCD) and Hu antibodies were found in nine (23%). Seven of the 16 VGCC antibody-positive patients had Lambert-Eaton myasthenic syndrome (LEMS). Seven of 15 CSF samples had VGCC antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar dysfunction.
A 51 year old man with paraneoplastic cerebellar degeneration from gastric adenocarcinoma showed cerebellar hypermetabolism and increased perfusion on brain FDG-PET scan and SPECT during the acute stage of his illness. The patient underwent subtotal gastrectomy. The intensity of the hypermetabolism had decreased markedly on follow-up FDG-PET 3 months later following two cycles of chemotherapy. We suggest that the cerebellar hypermetabolism may have been due to an acute inflammatory process associated with an immunological reaction.. ...
Anti Yo (PCA-1) ovarian and breast cancer; anti Tr antibodies -- Hodgkins lymphoma; also for Hodgkins lymphoma: Anti-mGluR1 and Anti Zic4 antibodies. Above are PREDOMINANTLY associated with PCD. SOMETIMES associated with PCD are anti VGCC (LEMS, small cell lung cancer); anti Hu (ANNA-1)(encephalomyelitis, PCD, sensory neuronopathy) (small cell lung and other CA); anti Ri (ANNA 2) (PCD, brainstem encephalitis; paraneoplastic opsoclonus/myoclonus)(breast, gyne and small cell CA);anti CV2/CRMP (encephalomyelitis, PCD, chorea, PN, uveitis)(small cell lung, thymoma, others); anti MA protein (limbic, hypothalamic, brainstem encephalitis, infrequently PCD)( testicular, lung and other cancers); antiamphiphysin (stiff person s, encephalomyelitis, PCD) (breast and small cell) CHART is FROM NEJM 2007; 356:612-620. MORE Tumors with anti Yo antibodies express Yo antigen which is a cytoplasmic protein called CDR2 that interacts with c-Myc. It is expressed in the Purkinje cells of the cerebellum and the ...
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Background Patients with intracellular onconeural antibodies may present with neuro-psychiatric syndromes. We aimed to evaluate the evidence for an association between well-characterized onconeural...
In the course of modeling the naturally occurring tumor immunity seen in patients with paraneoplastic cerebellar degeneration (PCD), we discovered an unexpectedly high threshold for breaking CD8+ cytotoxic T cell (CTL) tolerance to the PCD autoantigen, CDR2. While CDR2 expression was previously found to be strictly restricted to immune-privileged cells (cerebellum, testes, and tumors), unexpectedly we have found that T cells also express CDR2. This expression underlies inhibition of CTL activation; CTLs that respond to epithelial cells expressing CDR2 fail to respond to T cells expressing CDR2. This was a general phenomenon, as T cells presenting influenza (flu) antigen also fail to activate otherwise potent flu-specific CTLs either in vitro or in vivo. Moreover, transfer of flu peptide-pulsed T cells into flu-infected mice inhibits endogenous flu-specific CTLs. Our finding that T cells serve as a site of immune privilege, inhibiting effector CTL function, uncovers an autorepressive loop with ...
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There are comments on PubPeer for publication: Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration (2017)
For M.. Six months after being diagnosed with cerebellar degeneration, six months after a neurologist examined an MRI of my brain, leveled his eyes, cleared his throat and said to me, "you should be dead or in a hospital bed" Im staring at my physical therapist, Denise, and shes daring me to jump.. "Jay, I want you to jump.". "Like up and down?". "Yes, like jump up and down.". I smile and look around the St. Lawrence Rehabilitation Center. There are three other patients in the activity center with me. Two women, both walking slow on a treadmill and Bill, a former Navy Captain, who is the proud owner of a new titanium hip. Bill is pedaling a stationary bike and according St. Lawrence lore, Bill has never smiled. Ever.. Im the youngest one in the activity center by at least 20 years. This is problematic because comparison naturally feeds fiction. Surveying the room, like the true gym class hero I still think I am, I swell with pride believing Im the most able body in the room.. "Denise, need I ...
For M.. Six months after being diagnosed with cerebellar degeneration, six months after a neurologist examined an MRI of my brain, leveled his eyes, cleared his throat and said to me, "you should be dead or in a hospital bed" Im staring at my physical therapist, Denise, and shes daring me to jump.. "Jay, I want you to jump.". "Like up and down?". "Yes, like jump up and down.". I smile and look around the St. Lawrence Rehabilitation Center. There are three other patients in the activity center with me. Two women, both walking slow on a treadmill and Bill, a former Navy Captain, who is the proud owner of a new titanium hip. Bill is pedaling a stationary bike and according St. Lawrence lore, Bill has never smiled. Ever.. Im the youngest one in the activity center by at least 20 years. This is problematic because comparison naturally feeds fiction. Surveying the room, like the true gym class hero I still think I am, I swell with pride believing Im the most able body in the room.. "Denise, need I ...
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Renal Function: Creatinine clearance or radioisotope GFR ≥ 70ml/min/1.73 m2 OR A maximum serum creatinine (mg/dL) based on age/gender as follows: 1YO M&F = 0.6, 2-5YO M&F = 0.8, 6-9YO M&F = 1, 10-12YO M&F = 1.2, 13-15YO M = 1.5, 13-15YO F = 1.4, 16+ M = 1.7, 16+ F = ...
Renal Function: Creatinine clearance or radioisotope GFR ≥ 70ml/min/1.73 m2 OR A maximum serum creatinine (mg/dL) based on age/gender as follows: 1YO M&F = 0.6, 2-5YO M&F = 0.8, 6-9YO M&F = 1, 10-12YO M&F = 1.2, 13-15YO M = 1.5, 13-15YO F = 1.4, 16+ M = 1.7, 16+ F = ...
Yo La Tengo Maxwells Wednesday, March 23 Better than: Sitting home alone fretting about cataclysmic awfulness. Its been 26 years since Yo La Tengo played...
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DS is 2.5yo, suspected ASD (going through the assessment process). Were having a lot of issues with him being really rough with other kids, especially kids smaller than him. Today at a playground he ran up behind a small child and just - page 2
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I am suffering from head ache from last three months and also have a chest pain. Can you suggest what are the measure taken to cure it.-If you have recurrent...
Dr. Hyde responded: Trauma. It all depends on the injuries sustained. If the patient is in the icu, there must be specialists already involved in his care. Let the doctors perform the necessary tests in order to provide the best medical care in the most timely fashion.
My son is almost 11 and wont sleep alone. Hes afraid something bad will happen. We dont watch scary movies, we let him lock the doors and set the alarm when his....
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Entries for the 2017 Canadian Supreme Show must be received at our office by September 7th. No exceptions will be made. Each entry received after September 7th and before September 12th will be assessed a $200.00 late penalty. No entries will be accepted after September 12th. Denied credit cards, returned cheques and mail received after September 7, 2017 will not be considered timely payment and the $200 late fee will apply.. ...
When Ted Palen, a Kaiser Permanente researcher, started investigating what happens when doctors begin e-mailing with patients, he thought he would see the practice lighten workloads. Patients would get their questions answered remotely, with no need to turn up in person.
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The Black Keys have predictably sold out the Verizon Center. But there's no need to pay a scalper or StubHub your life's savings for tickets. The band will likely play Merriweather Post Pavilion at some point this summer
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Ive been up and down on the scale and have been on so many fad diets that weight loss and life seems like a big yo yo at times.
As a 61 yo type 2 diabetic, my GP informed me at last years physical (June 2009) that my T was low at 259 and that I might want to consider TRT. Since I was observing some of the symtoms of low T he started me on one tube of Testim/day and after 3 months my T increased to only 325. The dosage was then increased to 2 tubes/day and when it was rechecked last December it had risen to 499. After doing some further reading, I began to suspect Estradoil might be contributing to the problem so I start...
Im a 52yo (actually 22 for the 30th time, haha!!) Lookin like 42. Feelin like 32! Shootin for the next 48, and the big 100!! Whoohooo! Jus spreadin...
Read I Am Wonderfully Me Positive Affirmations for Me! Volume 3 by Audrey Tait with Rakuten Kobo. Where Is Your Focus in Life? Is it on others or on yourself? Do you look after yourself first, before others, so that yo...
Dd3 is 6mths today. My older two now almost 6&4yo started at 6-6.5mths. They eat almost EVERYTHING! We did BLW for both. Dh and I are wondering how late have people started their bub on solids. Anyone started around 7-8mths? Reason - page 3
If you could buy a few more years of life by sacrificing some of your health, would you? When would the trade stop being worth it to you-when yo.... ...
If you occasionally feel faint, especially when you rise from a lying or seated position, try the following: before standing, cross your legs, flex yo
ive never shared like this before but Im depressed. Im a 34yo female, I live with my parents (mom is also my caregiver), I never really go out, I dont really...
Today I was reading this post that seemed very common where someone had an idea of sort in an effort to create a business I guess yo can say. However, it s
Serological testing for anti-neural autoantibodies is important in patients presenting with idiopathic cerebellar ataxia, since these autoantibodies may indicate cancer, determine treatment and predict prognosis. While some of them target nuclear antigens present in all or most CNS neurons (e.g. anti-Hu, anti-Ri), others more specifically target antigens present in the cytoplasm or plasma membrane of Purkinje cells (PC). In this series of articles, we provide a detailed review of the clinical and paraclinical features, oncological, therapeutic and prognostic implications, pathogenetic relevance, and differential laboratory diagnosis of the 12 most common PC autoantibodies (often referred to as Medusa head antibodies due to their characteristic somatodendritic binding pattern when tested by immunohistochemistry). To assist immunologists and neurologists in diagnosing these disorders, typical high-resolution immunohistochemical images of all 12 reactivities are presented, diagnostic pitfalls discussed
Physician assistants and nurse practitioners use Clinical Advisor for updated medical guidance to diagnose and treat common medical conditions in daily practice.
Cerebellar ataxia is a common finding in patients seen in neurologic practice and has a wide variety of causes. Although cerebellar degeneration may be chronic and slowly progressive, acute cerebellar swelling due to infarction, edema, or hemorrhage
Below is a point-by-point response to the concerns raised by the editor and reviewer:. "I am pleased to inform you that your manuscript, "Rapid onset of motor deficits in a mouse model of spinocerebellar ataxia type 6 precedes late cerebellar degeneration," has been judged potentially suitable for publication in eNeuro, provided appropriate revisions are made. The decision was a result of the reviewers and I coming together and discussing our recommendations until a consensus was reached. I have put together a fact-based synthesis statement explaining the decision and appended it to this email.". We thank you and the reviewers for their time and helpful input.. "Synthesis Statement for Author (Required): The reviews are in good agreement and suggest that, while of potential interest to the field, additional information to address whether motor dysfunction at the 6-7 month time point observed in the 84Q expansion SCA6 model are due to degenerative events in, for example, the striatum are ...
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