A cross sectional study was carried out from October 2010 to April 2011 in Gondar Elfora Abattoir to determine the prevalence of paramphistomosis in cattle (local, cross) breeds which were came from highland, mid highland and lowland areas. Three hundred eighty-four (384) cattle were included for routine ante-mortem and postmortem examination for the presence of paramphistomum. The parasite was examined grossly and under microscope to appreciate the morphology of adult paramphistomum. Out of 384 cattle examined, 199 (51.82%) were found to be positive for paramphistomosis. From 199 infected cattle fluke burden at organ level 125(62.81%) was in rumen, 40(20.1%) was in reticulum and 34(17.09%) was found mixed (rumen and reticulum). The existence of paraphistomum in respect to organ and origin, 56(44.80%) was in rumen and 20(50%) was found in reticulum predominantly in high and low land respectively. The highest infection of cattle with paramphistomum species was found during October to November. However

Identification and Prevalence of Paramphistomum cervi Identification and Prevalence of Paramphistomum cervi in Naturally Infected Water Buffalos of Central Punjab. Зоология LAP LAMBERT Academic Publishing (2014-01-31) - ISBN-13: 978-3-659-52063-1 ...

المجلة العراقية للعلوم Iraqi Journal of Science A Refereed Science Journal Issued by the College of Science University of Baghdad Baghdad-Iraq. مجلة علمية محكمة تصدرها كلية العلوم- جامعة بغداد، بغداد- جمهورية العراق EISSN: 2312-1637 ISSN: 0067-2904

Adult, Cilia, Electron, Electron Microscopy, Fluke, Measures, Microscopy, Nipple, Paramphistomum, Pear, Rumen, Scanning Electron Microscopy, Separated, Spine

PUY DE DÔME, a department of central France, four-fifths of which belonged to Basse-Auvergne, one-sixth to Bourbonnais, and the remainder to Forez (Lyonnais), lies between 45° 17 and 46° 16 N. lat. and 2° 23 and 4 E. long. It is bounded on the N. by Allier, on the E. by Loire, on the S. by Haute-Loire and Cantal, and on the W. by Oorrèze and Creuse. The chief town, Clermont-Ferrand, is 217 miles south of Paris in a direct line; and the department takes its name from a volcanic cone (4800 feet) which overlooks it. A meteorological observatory has stood on the summit, on the site of an old Roman temple, since 1876. The highest point of the department, the Puy de Sancy (6188 feet), is also the most elevated peak of central France; it commands the group of the vol-canic Monts Dore, so remarkable for their rocky corries, their erosion valleys, their trap dykes and orgues of basalt, their lakes sleeping in the depths of ancient craters or confined in the valleys by streams of lava, and their ...

Below are two different maps of Saint Quintin, the Indre River and surrounding communities in the South Touraine, c1750-80. I love the Indre valley at this point in its meandering journey especially when, in spring, the buds on the small wood plantations are just appearing. The maps come from the terrific online collection of maps,…

original description Lamarck, J. B. (1801). Système des animaux sans vertèbres, ou tableau général des classes, des ordres et des genres de ces animaux; Présentant leurs caractères essentiels et leur distribution, dapres la considération de leurs rapports naturels et de leur organisation, et suivant larrangement établi dans les galeries du Muséum dHistoire Naturelle, parmi leurs dépouilles conservées; Précédé du discours douverture du Cours de Zoologie, donné dans le Muséum National dHistoire Naturelle lan 8 de la République. published by the author and Deterville, Paris: viii + 432 pp., available online at http://biodiversitylibrary.org/page/14117719 [details] ...

Chemical structures, data, literature and commercial sources for pharmaceutical, functional food and flavor & fragrance compounds

Principal Investigator：SHIMIZU Fujio, Project Period (FY)：1995, Research Category：Grant-in-Aid for international Scientific Research, Section：Joint Research

1. The theory went against common religious beliefs about life on Earth developed.. 2. Darwin couldnt explain why new, useful characteristics appeared or how they were inherited.. 3. There wasnt enough evidence to convince many scientists, because not many other studies had been done into how organisms change over time. Lamarck. Lamarck argued that if a characteristic was used a lot by an animal then it would become more developed. He reckoned that these acquired characteristics could be passed on to the animals offspring. But people eventually concluded that aquired characteristics dont have a genetic basis. So theyre unable to be passed on to the next generation. His theory was rejected.. ...

In chapter 3, The Sense of Sensibility, author Wendy Jones uses scenes from one of Jane Austens most celebrated novels to illustrate the functioning of the bodys stress response system.. 0 Comments. ...

In chapter 3, The Sense of Sensibility, author Wendy Jones uses scenes from one of Jane Austens most celebrated novels to illustrate the functioning of the bodys stress response system.. 0 Comments. ...

Many genes in the genome code for proteins. These are molecules of amino acids linked together in a very specific sequence that produce a functional molecule that can fold up to either be an enzyme, or a formed part of the structure of the cell, or to be secreted and act as signals. In all, there are thousands and thousands of proteins that your cells and body makes every single day. In the human genome, there are approximately 20,000 genes that code for proteins. Lawrence C. Brody, Ph.D ...

RNA oligo chemical synthesis는 그 서열의 secondary structure formation에 따라 합성이 제한될 수 있으며 300 bp 이상을 합성하기 어렵다는 단점이 있습니다. 이에 반해 In vitro transcription은 template-directed 합성방식으로 3kb이상의 RNA 합성이 가능하고 서열의 구조적 제한을 받지 않는 장점을 가지고 있습니다. SP6 또는 T7 RNA polymerase를 통해 합성된 RNA는 analytical technique, structural study, genetic study, functional molecule등에 활용 될 수 있습니다 ...

A biomarker, or biological marker, is in general a substance used as an indicator of a biological state. It is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarker discovery has been accelerated by proteomics, which study to entire protein expression at any given time in cell or tissue. If a certain protein is the functional molecule in cells, measurement of the differential expression of proteins could indicate disease-specific changes in tissues or organs.

A biomarker, or biological marker, is in general a substance used as an indicator of a biological state. It is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarker discovery has been accelerated by proteomics, which study to entire protein expression at any given time in cell or tissue. If a certain protein is the functional molecule in cells, measurement of the differential expression of proteins could indicate disease-specific changes in tissues or organs.

Del Guercio. 1905[1904]. Sulle differenze esistenti fra la Schizoneura Reaumuri Kalt. ed il Pachypappa vesicalis Koch e sulla convenienza di escludere la prima dal genere per essa indicate. Redia 2(2):306 ...

La distincion entre vertebrats e invertebrats foguèt iniciada per Jean-Baptiste de Lamarck. Lo grop dels invertebrats essent pas monofiletic, sa valor es remesa en causa dins las classificacions recentas. Permet çaquelà de distinguir lo sosembrancament al qual apartenen los òmes (los vertebrats) de totes los autres animals duna manièra antropocentrista. Aquò explicariá perqué los biologistas an fòrça de mal a abandonar aquesta classificacion e a la far doblidar al grand public. ...

A story from a week or so back in Technology Review describes research coming to the surprising conclusion that Jean-Baptiste Lamarck may have been right — that acquired characteristics can be passed on to offspring, at least in rodents. Lamarcks ideas have been controversial for 200 years, a...

Galeodes araneoides (Pallas): Olivier, 1791b: 579, 580; Lamarck, 1801: 176 (as aranoides [sic]); Lamarck, 1802 61 (as aranoides [sic]); Latreille, 1806: 133-136; Olivier, 1807: 443, plate 42 fig. 3; Latreille, 18lO: 425; Leach, 1814: 418; Lamarck, 1818: 79; Dumeril, 1820: 76; Duges and Edwards, 1836: plate 20 figs 1, 1a-f, plate 20 bis figs la, 1a-b; Guerin-Meneville, 1838b: 11, plate 4 figs 4a-d; Lamarck, 1838: 106-107; Lamarck, 1839: 300-301; C .L. Koch, 1842: 353; Gervais, 1844: 88, plate 26 fig. 1; C .L. Koch, 1847: 83-85, fig. 1475; C .L. Koch, 1850: 97; Dufour, 1861: 383-384; Wood, 1863: unnumbered fig. on p. 679; Butler, 1873: 418-419; Pavesi, 1876: 73; C L. Koch, 1878: 38; Simon, 1879a: 99-100; Simon, 1879c: 77; Croneberg, 1887: 163-164, figs 1-2; Pocock, 1889b: 118; Walter, 1889: 1096; Birula, 1890b: 66-68, figs 11-12; Birula, 1892: 687-688; Simon, 1892: 7; Birula, 1893: 82-87; Hansen, 1893: 185, 187; Birula, 1895a: 293-324, figs 1-12; Kraepelin, 1899a: 202; Kraepelin, 1899b: 376; ...

original description Lamarck, Jean Baptiste de. (1818). [USE FOR POLYCHAETA = Vol. 5. Annelides of ...] Histoire naturelle des Animaux sans Vertèbres, préséntant les caractères généraux et particuliers de ces animaux, leur distribution, leurs classes, leurs familles, leurs genres, et la citation des principales espèces qui sy rapportent; precedes dune Introduction offrant la determination des caracteres essentiels de l`Animal, sa distinction du vegetal et desautres corps naturels, enfin, lExposition des Principes fondamentaux de la Zoologie]. Paris, Deterville, 612 pp., available online at http://biodiversitylibrary.org/page/12886879 ...

The woman alleged to be the leader of the ETA Basque terrorist movements killer squads was arrested Sunday along with her boyfriend and number two in the heart of the Macon wine producing region of central France.

A semi soft blue cheese from the village of Beauzac in the Monts du Velay, part of the mountainous Auvergne region of central France. This rich, white cheese has characteristic olive green mould veins throughout and a smooth, creamy texture with a subtle mild spicy taste ...

Nuculidae is a family of small saltwater clams in the order Nuculoida. Species in this family are commonly known as nut clams. The nomenclature of the Western European species in this family is still uncertain. Their systematics has been based mainly on their feces. Acila H. Adams and A. Adams, 1858 Adrana Adams and Adams, 1858 Austronucula Powell, 1939 Brevinucula Thiele, 1934 Condylonucula D.R. Moore, 1977 Ennucula Iredale, 1931 Lamellinucula Schenck, 1944 Leionucula Quenstedt, 1930 † Linucula Marwick, 1931 Neonucula Lan & Lee, 2001 Nucula Lamarck, 1799 Pronucula Hedley, 1902 Sinonucula Xu, 1985 Genera brought into synonymy Lionucula Thiele, 1934 synonym of Ennucula Iredale, 1931 Nuculoma Cossmann, 1907 : synonym of Ennucula Iredale, 1931 Polyodonta Megerle von Mühlfeld, 1811 : synonym of Nucula Lamarck, 1799 WoRMS (2011). Nuculidae. Accessed through: World Register of Marine Species at http://www.marinespecies.org/aphia.php?p=taxdetails&id=204 on 2011-05-04 Nuculidae. Integrated ...

The versatility of hyaluronic acid is connected to not only its size, but also to inherent opportunities within the molecule for multiple bonds and for the differentiated release of bound functional molecules. Here, ester bonds are used to introduce substitutes for the materials alcohol groups, thus providing elasticizing, moisturizing and antiaging benefits for skin care.

The vast majority of the human genome does not code for proteins and, until now, did not seem to contain defined gene-regulatory elements. Why evolution would maintain large amounts of useless DNA had remained a mystery, and seemed wasteful. It turns out, however, that there are good reasons to keep this DNA. Results from the ENCODE project show that most of these stretches of DNA harbour regions that bind proteins and RNA molecules, bringing these into positions from which they cooperate with each other to regulate the function and level of expression of protein-coding genes. In addition, it seems that widespread transcription from non-coding DNA potentially acts as a reservoir for the creation of new functional molecules, such as regulatory RNAs. ...

In modern biology, all life, with the exception of some viruses, uses DNA as its genetic storage mechanism. According to the RNA-world hypothesis, RNA appeared on Earth first, serving as both the genetic-storage material and the functional molecules for catalyzing chemical reactions, then DNA and proteins evolved much later. Unlike DNA, RNA can adopt many different molecular conformations and so it is functionally interactive on the molecular level. In the research paper, two professors of chemistry, Christine Keating and Philip Bevilacqua, along with two graduate students, Christopher Strulson and Rosalynn Molden, probe one of the nagging mysteries of the RNA-world hypothesis.. A missing piece of the RNA-world puzzle is compartmentalization, Bevilacqua said. Its not enough to have the necessary molecules that make up RNA floating around; they need to be compartmentalized and they need to stay together without diffusing away. This packaging needs to happen in a small-enough space - ...

Scientists have developed a new process to structure surfaces and to apply or detach functional molecules. They use UV light for the formation or breaking of so-called disulfide bridges, i.e. bonds of sulfur atoms. Both photodynamic reactions allow for a temporally and spatially controlled and reversible modification of the surface and, hence, can be used to produce functional interfaces ...

Our research interests are highly interdisciplinary. We integrate chemistry, molecular biology, materials science, and medicine to solve important biomedical problems. Our main interest is to synthesize and engineer functional molecules that are useful for basic science, materials, and medical applications. Follow the links below for more detailed descriptions of current research interests.. ...

Weve often defended Jean-Baptiste Lamarck. Publishing 50 years before Darwin, he can be forgiven for not having the greatest idea anyone ever had and in the last few years, geneticists have gotten on board as well and no longer dismiss out of hand his belief that acquired traits can be passed on to offspring.

Many theories were put forward on basis of evolution (such as theory of Inheritance of Acquired Characteristics Jean Baptiste Lamarck)

Community chemotherapy campaigns to reduce malaria transmission often exclude pregnant women due to safety concerns related to the drugs. However, pregnant women might represent an important source of human-to-mosquito infection due to frequent parasite carriage with higher densities of parasites (often detectable by microscopy), attractiveness to mosquitoes, and modified sleeping behaviour. Accumulating evidence of the safety of artemisinin-based combination therapies for the treatment of malaria during gestation suggests that malaria elimination programmes should reconsider this exclusion. Including pregnant women will increase intervention coverage and impact, and may thereby accelerate progress towards the desired endpoint (e.g., elimination) or increase the chances of success. Studies assessing infectiousness of pregnant women and gametocyte dynamics during different trimesters of pregnancy will be valuable to support the planning of community treatment campaigns.. ...

In this study, specificity of snail feet and hepatopancreases antigens in antibody detection of their trematode parasite was evaluated via Western blot technique. Snails, of two different families, antigens; Lymnaea cailliaudi as intermediate host of Fasciola gigantica and Biomphalaria alexandrina as intermediate host of Paramphistomum microbothrium, were evaluated in detection of IgG antibodies against their trematode parasites after preparation of the required Hyper-Immune Sera (HIS) in rabbits. The results revealed higher specificity of snail feet in antibody detection than hepatopancreases antigens. Where, three of sex polypeptides of L. cailliaudi feet antigen; identified by F. gigantica HIS, showed specific positive reactivity. These polypeptides were at molecular weights of 59, 57 and 52 kDa. While, one of sex polypeptides of L. cailliaudi hepatopancreases antigen; identified by F. gigantica HIS, at molecular weight of 57 kDa was specific. Similarly, two polypeptides of B. alexandrina ...

Academic Journals Database is a universal index of periodical literature covering basic research from all fields of knowledge, and is particularly strong in medical research, humanities and social sciences. Full-text from most of the articles is available. Academic Journals Database contains complete bibliographic citations, precise indexing, and informative abstracts for papers from a wide range of periodicals.

A comparative study was performed of the essential oil extracted from the fruiting apex of Bupleurum gibraltaricum Lamarck (Umbelliferae) collected in different areas within the province of Granada, including the Cázulas mountains, the Balcón de Canales and the Quéntar Reservoir. All three essential …

Read The size and age structure of Tridacna crocea Lamarck, 1819 (Bivalvia: Tridacnidae) in the coastal area of islands of the Cön Dao Archipelago in the South China Sea, Russian Journal of Marine Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

which are well-known because of their notable functional properties (for instance,. Many previous researchers focus on wet-chemical methods for attaching the molecules to the surface of the material. The TUM team, however, decided to take a different approach: The researchers were able to link porphyrin molecules to graphene in a controlled manner in an ultra-high vacuum using the catalytic properties of a silver surface on which the graphene layer rested. When heated, the porphyrin molecules lose hydrogen atoms at their periphery and can thus form new bonds with the graphene edges ...

There are just two questions to be asked in evolution: how are things related, and what makes them differ? Lamarck was the first biologist-he invented the word-to address both. In his Philosophie Zoologique (1809) he suggested that the relationships among species are better described by branching trees than by a simple ladder, that new species arise gradually by descent with modification and that they adapt to changing environments through the inheritance of acquired characteristics. Much that Lamarck imagined has since been superseded. Following Wallace and Darwin, we now envision that species belong to a single highly branched tree and that natural selection is the mechanism of adaptation. Nonetheless, to Lamarck we owe the insight that pattern is produced by process and that both need mechanistic explanation.. Questions of pattern, process and mechanism pervade the modern discipline of molecular evolution. The field was established when Zuckerkandl & Pauling (1965) noted that haemoglobins ...

France's Constitutional Council is set to rule on Friday, 20 March, on whether mandatory immunisations are constitutional. It will rule on the case of a couple in central France who refused to vaccinate their eldest daughter. The couple's lawyer argues...

The species is endemic to Spain, Portugal and France. In south and west France, the species is rather common in eight departments only, rare in 12, and extinct in four. It is scattered and very rare in Spain and Portugal. The species is rather common only over 51,000 km² in France, from the lower Rhone river to the Charente-Maritime department via the southern edge of the Massif Central. It is rare to extinct elsewhere in France and in the west of central France it is much more scarce than one century ago, due to pollution and river management. In these areas the species is threatened with extinction or already extinct. Strong variations in densities are noticed from year to year ...

Mostly, the cloudy residents are bacteria of various kinds. Samples of clouds taken from a meteorological station at the summit of Puy de Dôme, a mountain in central France with an elevation of more than 1,400 meters (almost 5,000 feet), turned up more than 71 strains of bacteria, as well as a variety of fungi; owing to the way the sampling was done, this is a massive underestimate of whos up there. Of the bacteria detected, many appear to have come from the oceans. More than half have shown themselves capable of growing in cold temperatures, and some are even officially psychrophiles - lovers of cold. Which is to say, they grow when its cold, and not when its a bit warmer - unlike the bacteria on your food, which slow down when you put them in the fridge. One of the bacteria most often detected was Pseudomonas syringae; intriguingly, this critter has the ability to make ice crystals form around it at relatively warm (-2C, or 28.4F) temperatures.. As to their metabolism - the question of ...

A post by Rachel Stone. In the early 850s, the clergy and people of Nevers, a small city in central France, had a problem: their bishop, called Herimann, was behaving strangely. There were complaints of his excesses and the persistence of his frivolity (perseverantia levitatum). He had been frequently corrected for this behaviour and rebuked by other bishops moderately and sharply (modeste et acriter), but the problems had persisted.. But the unsuitable behaviour of this turbulent bishop was not solely due to Herimanns character flaws. The first account we have, from the Council of Soissons in April 853, also reports that he had some bodily trouble and talks of his infirmity. Later reports describe him as having lost the soundness of his understanding (sensus integritate privatus) and similar to the insane (insano similis). How did the Carolingian church respond to a bishop with what sounds like serious mental health problems? And what can this case tell us about the role of ...

Did you know that DNA can be damaged…and repaired?. DNA (deoxyribonucleic acid) is the hereditary material found in humans, animals, and organisms. DNA is in every cell in our bodies. Each cells nucleus has DNA, which is rolled into structures that are our chromosomes (23 pairs).. Most genes contain the information needed to make functional molecules called proteins. (A few genes produce other molecules that help the cell assemble proteins.) The journey from gene to protein is complex and tightly controlled within each cell. It consists of two major steps: transcription and translation. Together, transcription and translation are known as gene expression.. During the process of transcription, the information stored in a genes DNA is transferred to a similar molecule called RNA (ribonucleic acid) in the cell nucleus. Both RNA and DNA are made up of a chain of nucleotide bases, but they have slightly different chemical properties. The type of RNA that contains the information for making a ...

Principal Investigator：安倍 学, Project Period (FY)：2012-06-28 - 2017-03-31, Research Category：Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Project Area：Stimuli-responsive Chemical Species for the Creation of Functional Molecules

True Bloods Russell Edgington is on the loose, and apparently, there are only two vamps truly capable of taking him down... again. With the news that the most...

Directory of Open Access Journals Sweden. La edad media de las pacientes fue El peso medio de nacimiento fue gramos Tres neonatos presentaron trastornos alimentarios, uno hipoglucemia y otro enfermedad de membrana hialina, ductus arterioso permeable, sepsis y plaquetopenia. It has a high maternal and perinatal morbi-mortality rate. Maternal and neonatal variables were analized. Mean maternal age was MAH O Deteksi Fasciola hepatica dan Fasciola gigantica pada Kerbau Perah Fasciola hepatica dan Fasciola gigantica merupakan cacing kelas trematoda.. Telur cacing ini berbentuk oval dan dilengkapi dengan operculum yang berfungsi sebagai jalan keluar larva mirasidium pada saat telur menetas. Ukuran telur Fasciola gigantica lebih besar dibandingkan ukuran telur Fasciola hepatica. Penelitian ini bertujuan untuk mendeteksi telur cacing Fasciola Fascioliasis is a zoonotic infestation caused by the trematode fasciola hepatica. It presents a wide spectrum of clinical pictures ranging from fever and ...

All conformation dynamics approaches like Markov State Modelling require a Galerkin discretization of the underlying transfer operator. Despite considerable progress in the theory of transfer operators and metastability in the last decade, fundamental problems are still open. Adam Nielsen, working at ZIB as a graduate fellow at the Berlin Mathematical School, the joint graduate school of Berlins mathematics institutes, has solved one of these problems: We were able to show for which classes of ansatz spaces a set-based Galerkin discretization of the generalized transfer operator converges strongly in the L2 norm (FN:A. Nielsen, K. Fackeldey, M.Weber {2013}. On a generalized transfer operator, ZIB-Report 13-74.). Besides such rather fundamental results the research at ZIB still aims at novel algorithmic breakthroughs. One of the main algorithmic challenges in MD still is efficient generation of rare event statistics:Most of the available approach to sampling rare event statistics suffers from ...

Image-based cell profiling has become a common tool to identify phenotypic changes in cells exposed to various stimuli. To apply this approach to any research organism, we developed Image3C (Image-Cytometry Cell Classification), a tool that enables clustering of single cells based on their intrinsic phenotypic features by combining image-based flow cytometry with cell cluster analysis. We conducted a morphology analysis of hematopoietic tissue from zebrafish and a phagocytosis experiment. Here, Image3C could identify major hematopoietic cell lineages and, in addition, cells with specific functions, which abundance can be statistically compared between different treatments. To test the versatility of Image3C, we also clustered hemocytes of the apple snail Pomacea canaliculata obtaining results consistent with those collected by classical histochemical approaches. These experiments illustrate how Image3C can be used to classify and visualize heterogenous cell population obtained from either ...

The Charollais is a breed of domestic sheep originating in east central France, in the same region in which Charollais cattle originated, Charolles and Saône-et-Loire. It has a reputation as an easy lamber and is used as a terminal sire to increase muscling and growth rate of the lambs. It has been exported internationally, and is commonly used in the United Kingdom as a sire to produce market lambs from pure-bred ewes and mules. The Charollais sheep is a medium to large sized breed used as a terminal sire. The head is pinkish-brown and is usually free of wool but may have a fine covering of pale coloured hair and both sexes are polled. It is long in the back, wedge shaped and well-muscled. The breed is fine boned making for a high killing out percentage. The legs are brown, quite short and free of wool. On average at maturity, rams weigh 135 kg (300 lb) and ewes weigh 90 kg (200 lb). The fleece usually weighs between 2 and 2.5 kg (4.4 and 5.5 lb) and has a staple length of 4 to 6 cm (1.6 to ...

Two deposits of spectacular bronze artefacts dating back to the 9th century BC represent the latest discoveries made during a series of archaeological excavations and surveys conducted in the Allier department of central France since 2019. ...

A View of Moulins, Henri-Joseph Harpignies. In the Metropolitan Museum of Art; use the download or zoom icons under the image on their site.. At once straightforward and poetic, this view of a town in central France by the Barbizon painter is a beautiful example of the evocative power of watercolor. Harpignies combines solid draftsmanship, precise edges and loose, gestural applications of color in perfect balance. His composition is likewise a subtle balance of horizontal and vertical elements, connected by the thread of the irregular forms of the foliage and clouds.. I particularly love the briefly noted figures at the edge of the water - how simple and yet perfect they are.. ...

The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae.

Synthetic chemistry has the power to enable far-reaching investigations into human biology. Research in the Spiegel lab focuses on organic synthesis, with a specific emphasis on developing new methods and molecules that will facilitate our understanding and treatment of human disease. Ongoing projects range from synthetic reaction development and natural product synthesis to the construction of functional molecules capable of accomplishing specific biological tasks.. ...

Understanding the intrinsic properties of molecules, molecular building blocks and aggregates is key to realizing the bottom-up design of functional molecules and materials, and catalysts. We explore such molecular units in isolation, for example, via the pristine gas phase environment of specially modified mass spectrometers. The end goal of this research is the rational design of efficient catalyst and enzyme-like molecules.. The significant industrial potential of self-assembly to fabricate highly functional materials is hampered by a lack of knowledge of critical reaction intermediates, mechanisms and kinetics. Our groups research addresses this knowledge gap by developing methods to (1) directly observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution and (2) interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. This will determine the critical link ...

This work provides a simple but efficient way of constructing violet fluorescent helical nanofibers by the self-assembly of chiral π-π conjugated molecules, phenanthro[9,10-d]imidazole (PIM) derivatives. PIM derivatives are well-known functional molecules, but the construction of PIM into functional architec

Calix[4]tetra-diazonium cations generated in situ from the corresponding tetra-anilines were electrografted on gold and carbon substrates. The well-preorganized macrocyclic structure of the calix[4]arene molecules allows the formation of densely packed monolayers. Through adequate decoration of the small rim of the calixarenes, functional molecules can then be introduced on the immobilized calixarene subunits, paving the way for an accurate spatial control of the chemical composition of a surface at molecular level. One cool experiment is determination of surface coverage by functionalizing the electrode with COOH terminated calixarenes and then coupling on Fc moieties and doing CV ...

Regulatory T cells (Tregs) act by suppressing the activation and effector functions of innate and adaptive immune responses. we show that equivalent conclusions were drawn from the mix of markers utilized to define Tregs no matter. Our outcomes also showed elevated appearance of cell routine markers (Ki67 and cyclin B) in Tregs from neglected infected individuals, that have been reduced by HAART. However, the Treg phenotype in untreated patients was not consistent with a higher level of generalized activation, as they expressed very low levels of CD69, slightly elevated levels of HLA-DR and comparable levels of GARP compared to Tregs from uninfected donors. Moreover, none of these markers was significantly changed by HAART. Treg expression of CTLA-4 and cytotoxic molecules was identical between patients and controls. The most striking difference in terms of functional molecules was the high expression of CD39 by Tregs in untreated patients, which HAART just handled partly. Launch Regulatory T ...

Our laboratorys research activities are devoted to the development of chemical sensors and biosensors. Our work covers the entire range of sensor development from the creation of functional molecules (e.g. molecular probes), over nano- and micro-sized functional materials (e.g. polymeric nanoparticles), to entire sensing systems.. ...

Molecular therapies target key functional molecules in order to halter viable operation of cancer cells. Receptor tyrosine kinases (RTKs) constitute attractive targets, as quite often their abnormal signaling has been associated with tumor development and growth. Overexpression of growth factor receptors, including IGF, EGF, TGF-α, SCF and PDGF receptors, has been associated with poor prognosis in breast cancer. Therefore, a number of RTKs are already targets for novel designed drugs, which involve tyrosine kinase inhibitors and monoclonal antibodies. Despite the fact that c-Kit and PDGF-R have been effective targets in a number of cancers, the experimental results in breast have not yet clarified their importance. The expression and function of c-Kit in breast cancer is a quite controversial subject. Several studies propose that the loss of c-Kit expression has been associated with tumor progress, whereas other reports indicate not only its expression but also the implication of c-Kit in ...

LAMARCKISM An important 19th century error was the theory of *Jean Baptist Lamarck (1744-1829), later called Lamarckism. It is the theory of inheritance of acquired characteristics, and was solidly disproved by *August Weismann in 1891, when he cut the tails off of 19 successive generations of rats and they and their offspring continued to grow tails! Later still, when the inheritance of characteristics was found to depend on the DNA genetic coding and not habits or environmental circumstances, the reason why Lamarckism could not work was then understood.. Lamarckism teaches that one animal grew an organ for some reason or no reason at all,and then passed that organ on to the next generation, which was stuck with it.. Here are several additional examples of acquired traits which were never passed on to offspring: (1) Hebrews circumcised their boys for thousands of years, but never have boys been born automatically circumcised as a result. (2) Chinese women bound the feet of their infant girls ...

La biologjie e je la sience che studie la vite in dutis lis sôs formis. Il non biologjie al è stât inventât tal XVIII secul dal studiôs francês Jean-Baptiste Pierre Antoine de Monet, cavalîr di Lamarck. Va dite che nol è simpri facil distingui fra organisims vivents e no vivents (par esempli i virus), par chest logjet de biologjie nol è che al sedi simpri clarementri identificât. Cuant che si studiin lis molecolis, lis celulis e i organisims microscopics la biologjie e à a ce fâ cu la fisiche e cu la chimiche e i confins fra chestis siencis no son nets. ...

La biologjie e je la sience che studie la vite in dutis lis sôs formis. Il non biologjie al è stât inventât tal XVIII secul dal studiôs francês Jean-Baptiste Pierre Antoine de Monet, cavalîr di Lamarck. Va dite che nol è simpri facil distingui fra organisims vivents e no vivents (par esempli i virus), par chest logjet de biologjie nol è che al sedi simpri clarementri identificât. Cuant che si studiin lis molecolis, lis celulis e i organisims microscopics la biologjie e à a ce fâ cu la fisiche e cu la chimiche e i confins fra chestis siencis no son nets. ...

In the early twentieth century, Paul Kammerer conducted a series of experiments to demonstrate that organisms could transmit characteristics acquired in their lifetimes to their offspring. In his 1809 publication, zoologist Jean-Baptiste Lamarck had hypothesized that living beings can inherit features their parents or ancestors acquired throughout life. By breeding salamanders, as well as frogs and other organisms, Kammerer tested Lamarcks hypothesis in an attempt to provide evidence for Lamarcks theory of the inheritance of acquired characteristics.. Format: Articles Subject: Experiments ...

It is not improbable that Mitra bifasciata, (Zool. Ill. pl. 35.) may eventually be considered only a variety of the shell here figured, which accords much closer with the characters given of the Linnæan M. caffra, than any other; the two shells, however, at the first glance, have a widely different appearance; yet not more so, than the smooth and plaited varieties of Strombus vittatus Lin. I have therefore retained the character given by Lamarck, as the best method to be followed in doubtful cases. In this shell, the plaits commence halfway round the body whirl; they are obtuse, crowded, and not angulated near the suture; the striæ between are fine and decidedly marked; the base half of the shell strongly grooved; the suture rather compressed; the channel short and not recurved, and the aperture striated.. ...

Risale agli anni Settanta il proposito di Achille Maramotti di costituire una raccolta darte contemporanea che diventasse un luogo di fruizione estetica e intellettuale, aperto a un pubblico di appassionati. Fino al 2000 un certo numero delle opere acquistate erano esposte negli spazi di passaggio dello stabilimento Max Mara di via Fratelli Cervi per promuovere una quotidiana, […]. ...

Methods 99 patients with active early RA were enrolled into an investigator-initiated, randomized, double-blind, trial, the NEO-RACo trial. They were treated with an intensified combination (FR) of MTX, SASP, HCQ, low-dose prednisolone, and intra-articular glucocorticoid (GC) injections for 2 years. In addition, they were randomized to receive an added-on induction treatment with either infliximab (FR+INFL group) or placebo (FR+Pla group) infusions for the initial 6 months. Patients were assessed clinically 11 times during the first 12 months and thereafter every 3 months. At all times, treatment was targeted to a modified strict ACR remission with increase of drug doses or switch between DMARDs, as well as GC injections into swollen joints, if RA was active. Data about RA-related lost workdays (ABS) were gathered, as well as about self-reported PRES with VAS. The monetary value of lost productivity was estimated by the human capital method based on the mean earnings of all employees obtained ...