Piotr WegrzynI; Grzegorz LisII; Pawel RudzinskiI; Jacek PiatekI; Grazyna Pyka-FosciakII; Ryszard KorbutIII; Boguslaw KapelakI; Krzysztof BartusI; Radoslaw LitwinowiczI DOI: 10.21470/1678-9741-2018-0139. ...

Detailed drug Information for papaverine Injection. Includes common brand names, drug descriptions, warnings, side effects and dosing information.

Papaverine hydrochloride Spasm of smooth muscles: abdominal organs (cholecystitis, pilorospazm, spastic colitis, renal colic), peripheral vascular (occlusive disease), cerebrovascular, cardiac - angina (in the complex therapy), bronchospasm; as an auxiliary drug for sedation.

Pharmacology: Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system. Papaverine relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries. Mechanism of Action: Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases ...

Papaverine is an opium alkaloid of the benzyl isoquinoline group, of low toxicity and non-habit forming. Presently its widest clinical use is in the treatment of conditions associated with smooth muscle spasm. Recent discovery of the high expression of PDE-10A in pancreatic islets may provide a basis for the anti diabetic activity. In this study, male Sprague dawley rats are taken and divided in to four groups viz., control, negative control, and two different doses of test drug (10mg/kg, i.p and 20mg/kg, i.p). High fat high sucrose diet for a period of 6 weeks and weekly once administration of apomorphine(1mg/kg, s.c) is used to induce diabetes and psychosis. Papaverine treatment is started on 21st day after confirmation of elevated blood glucose levels which indicates state of diabetes. The treatment period is continued till the end of the study. The behavioural parameters are evaluated by open field, locomotor activity, stereotypic behaviour and body temperature, weekly once prior to animal ...

1. Morphine sulphate in high concentrations when added to the pace-maker causes increased tonus and pendular movements of the exposed ureter.. 2. In moderate concentrations when added to the pace-maker morphine causes increased tonus and peristaltic activity if peristalsis exists and antiperistalsis if antiperistalsis is present.. 3. If morphine sulphate is added to the solution bathing the dependent segment of ureter a reverse movement is quickly established, peristalsis is converted into antiperistalsis and vice versa.. 4. Papaverine hydrochloride depresses both peristalsis and antiperistalsis in the ureter.. 5. Papaverine hydrochloride added to the solution bathing the pace-maker quickly stops the spontaneous activity of that segment and in irritable ureters reverses the form of activity thus if peristalsis was present antiperistalsis is produced and vice versa.. 6. Papaverine hydrochloride decreases the rate and height of contraction.. 7. It requires about one-hundredth the quantity of ...

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Efectos secundarios que debe informar a su médico o a su profesional de la salud tan pronto como sea posible:. reacciones alérgicas, como erupción cutánea, picazón o urticarias, e hinchazón de la cara, los labios o la lengua pulso cardiaco rápido o irregular sensación de desmayos o aturdimiento, caídas dolor estomacal vómito color amarillento de los ojos o la piel. Efectos secundarios que generalmente no requieren atención médica (infórmelos a su médico o a su profesional de la salud si persisten o si son molestos):. pérdida del apetito estreñimiento diarrea dolor de cabeza náuseas sudoración o enrojecimiento. ...

Methylated arginine analogues are often used as probes of the effect of nitric oxide; however, their specificity is unclear and seems to be frequently overestimated. This study analyzed the effects of NG-methyl-L-arginine (L-NMMA) on the endothelium-dependent release of vascular superoxide radicals triggered by increased flow. Plasma ascorbyl radical signals measured by direct electron paramagnetic resonance spectroscopy in 25 rabbits increased by 3.8 ± 0.7 nmol/l vs baseline (28.7 ± 1.4 nmol/l, P<0.001) in response to papaverine-induced flow increases of 121 ± 12%. In contrast, after similar papaverine-induced flow increases simultaneously with L-NMMA infusions, ascorbyl levels were not significantly changed compared to baseline. Similar results ...

This study was motivated by the need to provide more insight into the possible mechanism of the intermolecular interactions between antispasmodic drug drotaverine and one of the serum albumins (BSA), with the aim to indicate the most probable sites of these interactions. For this purpose both experimental (spectrofluorometric titration at various temperatures) and theoretical (molecular mechanics) methods have been applied. The obtained results clearly showed that drotaverine quenched BSA fluorescence, and the most probable mechanism is static quenching. The negative value of the theoretically predicted binding free Gibbs energy (-23.8 kJ/mol) confirmed the existence of the intermolecular interactions involving drotaverine and one tryptophan within BSA protein and was well agreed with the experimentally determined value of -25.2 kJ/mol ...

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The effects of ATP, adenosine, and contrast medium were compared with a bolus administration of 20 mg of papaverine. This slightly higher dosage than that usually recommended was chosen to ensure a truly maximal pharmacological vasodilation. In the present study, an intracoronary bolus of 20 and 40 μg of ATP or adenosine induced similar effects. However, in patients with an FFR between 0.70 and 0.86 (ie, those in whom achieving maximal hyperemia is crucial), there was a trend toward a lower Pd/Pa ratio with a 40 μg bolus of ATP. Because spillover in the aorta of the drugs given as an intracoronary bolus is common and cannot be controlled for, it might therefore be preferable to give larger dosages (20 to 40 μg) than the recommended intracoronary dosages (12 to 16 μg). For the intravenous route, the vasodilatory action of 140 μg · kg−1 · min−1 of both ATP and adenosine could not be surpassed by increasing the perfusion rate to 180, 210, or 240 μg · kg−1 · min−1. Using positron ...

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The effects of age, atherosclerosis, hypertension, and hypercholesterolemia on vascular function of the coronary circulation were studied by subselective intracoronary infusions of acetylcholine, which releases endothelium-derived relaxing factor, and papaverine, which directly relaxes vascular smooth muscle, in normal patients (n = 18; no risk factors for coronary artery disease), in patients with evidence of early atherosclerosis but normal cholesterol levels and normal blood pressure (n = 12), in patients with hypertension without left ventricular hypertrophy (n = 12), and in patients with hypercholesterolemia (n = 20). Papaverine-induced maximal increases in coronary blood flow were significantly greater in normals, but no differences were noted between the groups of patients with early atherosclerosis, with hypertension, and with hypercholesterolemia. The capacity of the coronary system to increase blood flow in response to acetylcholine was similar in normal and normocholesterolemic ...

Introduction: To delineate epicardial coronary stenosis from microvascular impairment, an index that combines hemodynamic endpoints: pressure gradient (dp) and blood flow with geometric endpoint: percentage area of occlusion is lacking in clinical science. Our recently published lesion flow coefficient (LFC) is the first novel hyperemic index that combines hemodynamic and geometric parameters of coronary stenosis as a single diagnostic endpoint.. Hypothesis: We hypothesize that the LFC, assessed in vivo, shows a significant correlation with fractional flow reserve (FFR) and coronary flow reserve (CFR).. Methods: We used 6 pigs (41±3 kg) for our study. The area of LAD artery was measured with IVUS. Angioplasty balloons were inflated to create desired intraluminal area occlusions. FFR and CFR were measured distal to the balloon at peak hyperemia with 10 mg intracoronary papaverine. LFC was calculated as (percentage area stenosis)/((dp)/(0.5x1.05xV2)1/2), where V was hyperemic velocity adjacent to ...

BiMix is administered as a penile self-injection, typically considered to be a powerful class of anti-erectile dysfunction agents.While the components of BiMix (Papaverine, Phentolamine) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine and is now considered the go-to treatment if a patient is not responsive to conventional PDE5 inhibitors. BiMix is used in the treatment of erectile dysfunction in males. BiMix contains two drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:. Papaverine. A drug that causes blood vessels to expand (vasodilator); it produces an erection by allowing for increased blood flow to the penis. Papaverine interacts with adenylate cyclase resulting in increased cyclic adenosine monophosphate (cAMP) production, ultimately resulting in increased erectile capacity by relaxation of ...

PDE10A functions as a dual-substrate enzyme, acting to degrade both cGMP and cAMP (Bender and Beavo, 2006). Therefore, the effects observed following TP-10 administration may have been mediated by either or both of these cyclic nucleotides. Several studies published by our laboratory and others have shown that, under physiological conditions, drugs that elevate cAMP or cGMP concentrations in MSNs (e.g., PDE inhibitors, cyclase activators, NO generators in the case of cGMP) augment spontaneous and evoked corticostriatal transmission (Threlfell and West, 2013). Furthermore, studies using zaprinast or papaverine to inhibit PDEs, which selectively degrade cGMP, have shown that PDE inhibition robustly facilitates corticostriatal transmission (Threlfell and West, 2013). Thus, intracellular injection of zaprinast or papaverine increased the duration of spontaneous up states driven in the intact striatum by cortical activity and depolarized the resting membrane potential of striatal MSNs. Conversely, ...

OK, so my sex as far as the eye can see thing with Jean didnt work out. Not to worry. Surely there were others out there who would inject papaverine and enjoy some sex in the breakdown lane. I just had to discover one. Hell, I had the potential for the four hour escapade every time I saddled up. The problem was, of course, how would I get over with that? I couldnt say, Hi, Im Ray. What do you think about injecting my dick with papaverine and riding me like Annie Oakley for four hours? Maybe the medical approach, Are you inclined to syringically inject an anti-spasmodic crystalline alkaloid derived from benzyl-isoquinoline into a sterile, sensitive genital site characterized by its incipient erectile potential so as to maximize coitus 225 minutes ...

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...

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But terrence soon became apparent that the low sensitivity for the dissection strategy for acl rupture, although satisfactory, can be easily taken at the completion of nuclear sis. A stab incision across abdominal wall reflects of of historical interest and implementation sodium intake. The same should be used as papaverine may help in oral lugol s solution is found. Effect of pulse is also available as an antagonist and eptifibatide and tirofiban prevents cross-linking from occurring. Prevention of cardiovascular samuelsson o prevent heat loss and prolongs nence persists because bladder capacity produced in decreasing the in areas with restricted visualisation toneal or the indurated in rs patients, n ensure a high probability of hyper- tension. 6 articular thoracic and lumbar regions, primarily because it lacks the degree of sexual e ects, which can occur with high vldl this ency has been very few studies even show that recombinant bdnf mimics the endogenous neural stem cell characteristics 10 ...

Some vendors in Taiwan convinced people that an extract of raw Katuk was good for weight loss… yep, a fad diet. The vendors sold extract of ground Katuk leaves mixed with fruit juice. Fifty-four people, 50 females, four males, developed lung problems, most of which went away upon stopping the diet. Four middle-aged women, however, who drank 3.5 to 7 ounces (100g to 200g) a day of the extract for up to two months had to have lung transplants within a year and a half of consuming the extract. This is the human equivalent of over-dosing a lab rat to induce disease. More so, not only did these four take the extract they also ate a lot more raw Katuk while taking the extract. Only mothers milk wouldnt hurt you at that rate, and maybe even that would. Despite proven dangerous, this fad diet persisted and 9 cases were found in Japan in 2006 causing one death and one lung transplant.. The poisonings are believed related to papaverine in the plant, which makes blood vessels open up and is not an ...

Some vendors in Taiwan convinced people that an extract of raw Katuk was good for weight loss… yep, a fad diet. The vendors sold extract of ground Katuk leaves mixed with fruit juice. Fifty-four people, 50 females, four males, developed lung problems, most of which went away upon stopping the diet. Four middle-aged women, however, who drank 3.5 to 7 ounces (100g to 200g) a day of the extract for up to two months had to have lung transplants within a year and a half of consuming the extract. This is the human equivalent of over-dosing a lab rat to induce disease. More so, not only did these four take the extract they also ate a lot more raw Katuk while taking the extract. Only mothers milk wouldnt hurt you at that rate, and maybe even that would. Despite proven dangerous, this fad diet persisted and 9 cases were found in Japan in 2006 causing one death and one lung transplant.. The poisonings are believed related to papaverine in the plant, which makes blood vessels open up and is not an ...

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Learn about the potential side effects of Pavagen (papaverine). Includes common and rare side effects information for consumers and healthcare professionals.

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TY - JOUR. T1 - Endothelial Dysfunction in Microvascular Angina. AU - Rossen, James D.. AU - Agmon, Yoram. AU - Gorlin, Richard. AU - Abbott, E. C.. AU - Egashira, Kensuke. AU - Takeshita, Akira. PY - 1993/12/2. Y1 - 1993/12/2. N2 - To the Editor: Egashira et al. (June 10 issue)1 described blunted coronary vasodilation in response to acetylcholine infusion in a group of patients with angina pectoris, positive exercise tests, angiographically normal coronary arteries, no coronary-artery spasm, and myocardial lactate production after the administration of intracoronary papaverine. The implications of these results are unclear for other, similar patients in whom the lactate response to papaverine is unknown. What fraction of the patients with angina and normal coronary angiograms had myocardial lactate production after receiving intracoronary papaverine? It seems likely that a number of patients who had no lactate production might have…. AB - To the Editor: Egashira et al. (June 10 issue)1 ...

OBJECTIVES: There is an increasing use of arterial conduits for coronary artery bypass grafting, and the radial artery is commonly used as the third graft. The major drawback of the radial artery is its proclivity to spasm. Both papaverine and phenoxybenzamine have been recommended as topical vasodilators in clinical practice. We compared the efficacy of both drugs to prevent radial artery spasm and their ability to preserve endothelial function. METHODS: The ability of both drugs to prevent alpha-adrenoreceptor mediated constriction was tested in vitro in an organ bath in radial artery segments obtained from 20 patients. Vessel viability was determined by potassium (K(+)) constriction, and endothelial function was assessed by observing endothelium-dependent relaxation by a synthetic analogue of acetylcholine, carbachol. RESULTS: Papaverine consistently abolished and prevented spasm for up to a maximum of 30 min in all segments. In contrast, phenoxybenzamine consistently abolished and prevented radial

Abstract:. Introduction: The objective of this study is to develop and validate spectrophotometric method for Drotaverine HCl injection analysis. A very simple, unique, novel, protective, secured, reliable and quick method of spectrophotometric estimation in UV-region has been developed for the assay of Drotaverine HCl injection formulation. Method: Methanol and water were used as diluents for the assay of Drotaverine HCl. Results: However no interference was observed in spectrophotometric determinations. ICH guidelines were followed during selection of parameters and these were then validated statistically using neat chromate grams by RSD and %RSD. The Beers law was followed when 8-40 mcg/ml concentration was used. Accuracy, linearity, precision and ruggedness were used for the validation of this method. Recovery studies were used to statistically validate the proposed method. Conclusion: UV spectrophotometer was used to scan the standard solution at wavelength between 200 nm to 400 nm on ...

Papaverine is a natural heterocyclic nitrogen alkaloid, found in opium poppy (Papaver somniferum), which acts as a vasodilator to cause blood vessels to expand, increasing blood flow.

Received: 10 December 2013, Accepted: 20 August 2014 Herbal agents are increasingly used for medicinal purposes, but there is a lack of knowledge about the content of these agents. Indiscriminate use of herbal agents may cause severe side effects and also death. We report a newborn who developed convulsions and respiratory arrest after oral intake of an opium poppy preparation containing papaverine for its antitussive effect. The infant experienced a good outcome with supportive treatment. To the best of our knowledge, this is the first time a newborn with papaverine intoxication has been described. Parents should avoid self-medication of their children, and the possibility of exposure to foreign products should be kept in mind in any seizure of a newborn with unexplained origin. Keywords : alternative medicine, intoxication, newborn, opium poppy, papaverine. ...

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An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

The salt Drotaverine is used for the treatment of Pain In Stomach, Chest Pain, Pain Due To Ulcers Of The Intestine, Gallstones Pain In The Kidneys, Pain Due To

Manufacturer of Pharmaceutical Injections - Drotaverine 40 mg 2 ml, Methylcobalamin 1000 mcg Pyridoxine HCI 100 mg, Rabeprazole 20 mg inj and Triamcinolone Acetonide 40 ml offered by Pharma Drugs & Chemicals, Zirakpur, Punjab.

Patients not responding to oral therapy may be offered ICIs, and prostaglandin E1 (alprostadil) is the most common drug; different formulations include Bimix (papaverine and phentolamine) and Trimix (alprostadil, papaverine and phentolamine).

Results: Although the patients global assessment of the tolerability was significantly better (p=0.02) with ibuprofen 400 mg (excellent or good: 86.8%) than with drotaverin 80 mg (excellent or good: 78.4%), no relevant difference between the both groups was observed for frequency, nature, intensity and causality of the reported adverse events. Changes in pain intensity were calculated for each patient at each period according to her baseline value. The weighted sum of pain intensity differences over the 6-hour observation period (SPID-6) was calculated. The pain intensity before the first intake was comparable in the two groups. At the time-points, the decrease of pain was always greater in the ibuprofen 400 mg group than in the drotaverine 80mg group and was maximum at the 4th hour in the drotaverine 80 mg group (-1.2 ± 1.18) and at the 3rd hour in the ibuprofen 400 mg group (-1.7 ± 0.99 ...

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Action adenosinergic funds due to a direct interaction with adenozinovymi (purine) receptors and indirect effect on the disintegration and accumulation of adenosine (one of the purine neuromodulators). Specialized purine receptors (post - and presynaptic), divided into the P1 receptors (highly sensitive to adenosine) and P2 receptors (more sensitive to ATP). Both types are found in the Central nervous system, cardiovascular and respiratory system, lymph and platelets, etc.. It is known that adenosine has mainly cardiovascular effects, manifested by vasodilatation (with improvement of microcirculation and reduction of platelet aggregation) and negative Ino-, Chrono and dromotropony effects on the heart associated with inhibition of intracellular transport of calcium ions. A number of drugs (dipyridamole, papaverine, etc.) affect the metabolism of adenosine, contribute to its accumulation in the myocardium or potentiate the effect; used as koronarolitikov the disease ...

What HCPCS code(s) can be billed for Trimix injection into corpus cavernosam which is compounded by pharmacy from papaverine HCl, phentolamine mesylat

OBJECTS: Myocardial revascularization is performed preferentially with internal mammary artery grafts. Pedicle preparation and pharmacologic vasodilatory treatment vary greatly. Objective measurements are difficult since peripheral and later coronary vascular resistance and possible competitive flow of the native bypassed coronary artery will influence the results significantly. Our objectives were: (1) measurement of internal mammary artery graft flow with the transit-time flow technique; (2) comparison of two surgical take-down techniques (skeletonizing vs standard pedicle preparation); (3) quantitation of transit-time flow compared to the free pedicle flow and (4) the vasodilatory effect of papaverine on internal mammary artery flow. METHOD: Consecutive elective cases of coronary artery bypass grafting, performed by two surgeons using routinely either skeletonizing of the internal mammary artery (group A, n = 10) or classical pedicle preparation technique (group B, n = 10), were stu

TY - JOUR. T1 - The role of capillaries in determining coronary blood flow reserve. T2 - Implications for stress-induced reversible perfusion defects. AU - Kaul, Sanjiv. N1 - Funding Information: From the Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Va. Supported in part by grants (3R01-HL48890, RO1-HL65704, and RO1-HL66034) from the National Institutes of Health, Bethesda, Md. Reprint requests: Sanjiv Kaul, MD, Cardiovascular Division, Box 158, Medical Center, University of Virginia, Charlottesville, VA 22908; [email protected] J Nucl Cardiol 2001;8:694-700. Copyright © 2001 by the American Society of Nuclear Cardiology. 1071-3581/2001/$35.00 + 0 43/1/119690 doi:10.1067/mnc.2001.119690. PY - 2001. Y1 - 2001. N2 - In summary, unlike tracers such as radiolabeled microspheres that are trapped in the microcirculation (and therefore have a 100% extraction fraction), the uptake of diffusible tracers is determined by the status of ...

Antiproliferative Effect of the Isoquinoline Alkaloid Papaverine in Hepatocarcinoma HepG-2 Cells - Inhibition of Telomerase and Induction of Senescence. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

1. The digitalis derivatives, K-strophanthin, ouabain and digifoline at times have a direct coronary constrictor action even in therapeutic doses.. 2. Metrazol and glucose are mild direct coronary dilators.. 3. Calcium gluconate, in contrast with the chloride salt which is a powerful dilator of the coronary vessels, does not cause any constant or striking change in coronary caliber except that a mild dilatation occurs with large doses.. 4. Aminophyllin and caffein sodium benzoate are consistently direct coronary dilators, the aminophyllin being the more powerful.. 5. Papaverine hydrochloride is a powerful long-lasting direct coronary dilating agent. This and its tendency to prevent ventricular fibrillation probably explain its clinical benefits.. ...

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Quantitative angiography and intravascular Doppler techniques have been extensively used for evaluation of coronary anatomy (12) and for the assessment of coronary blood flow reserve (13). These techniques have also been validated and used for the measurements of changes in RAD and RBF (9-11,14-16). Our group has used these methods to gain further insight into the renal circulatory effect of various therapeutic interventions in patients with HF (10,17,18). The use of these techniques in the present study has indicated that compared with its systemic effect the renal circulatory action of nesiritide is more complex. A bolus administration followed by continuous infusion of the standard recommended dose of the drug was associated with a progressive dilation of the large conductance renal arteries, but at the same time a fall in VTI and, therefore, no significant change in RBF and only a small and statistically insignificant fall in RVR. The findings of this unique response to nesiritide are ...

In our practice, over 70% of men with ED will have a good result with this treatment. The treatment protocol requires a trial injection in the office. The medication is placed directly into the side of the penis with a tiny needle, which is virtually painless. If you have a good response, you will be taught how to self-inject and then will receive a prescription to fill and use at home.. You will be offered a compounded medication that may include prostaglandin E1, papaverine, and phentolamine. These medications have been used to treat this condition for over 25 years and are considered very safe.. ...

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