Antibodies for proteins involved in palmitoyl-CoA hydrolase activity pathways, according to their Panther/Gene Ontology Classification

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.

ENCODES a protein that exhibits lysophosphatidic acid binding (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); palmitoyl-CoA hydrolase activity (ortholog); INVOLVED IN adult locomotory behavior (ortholog); associative learning (ortholog); brain development (ortholog); PARTICIPATES IN fatty acid elongation pathway; ASSOCIATED WITH central core disease (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); COVID-19 (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); extracellular region (ortholog)

This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011 ...

Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene. This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms. The ACOT11 gene is located on the 1st chromosome, with its specific localization being 1p32.3. It contains 18 exons. The protein encoded by this gene contains 258 amino acids, and forms a homodimer with another chain. Its theoretical weight is 26.67 kDa. The protein contains a StAR-related transfer domain, ...

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs ...

Complete information for ACOT2 gene (Protein Coding), Acyl-CoA Thioesterase 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Complete information for ACOT1 gene (Protein Coding), Acyl-CoA Thioesterase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

border=1 cellspacing=0 !Gene!!Start!!End!!HK Gene!!Expression Breadth!!Description!!GO Term!!GO Function ,- ,ABHD12,,25223378,,25319477,,N,,17,,abhydrolase domain containing 12,,0016021,,integral to membrane ,- ,ACOT8,,43903767,,43919442,,N,,17,,acyl-CoA thioesterase 8,,0005515,,protein binding ,- ,ACSS1,,24934872,,24987616,,N,,16,,acyl-CoA synthetase short-chain family member 1,,0000166,,nucleotide binding ,- ,ACSS2,,32926405,,32979423,,Y,,18,,acyl-CoA synthetase short-chain family member 2,,0008610,,lipid biosynthetic process ,- ,ACTR5,,36810510,,36834503,,N,,12,,ARP5 actin-related protein 5 homolog (yeast),,0045449,,regulation of transcription ,- ,ADA,,42681576,,42713790,,N,,15,,adenosine deaminase,,0005515,,protein binding ,- ,ADAM33,,3596619,,3610738,,N,,10,,ADAM metallopeptidase domain 33,,0016020,,membrane ,- ,ADIG,,36643251,,36650518,,N,,1,,adipogenin,,0050873,,brown fat cell differentiation ,- ,ADNP,,48940289,,48980934,,Y,,18,,activity-dependent neuroprotector ...

Acot6 - mouse gene knockout kit via CRISPR, 1 kit. |dl||dt|Kit Component:|/dt||dd|- |strong|KN300736G1|/strong|, Acot6 gRNA vector 1 in |a href=http://www.origene.com/CRISPR-CAS9/Detail.

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge ...

Kit Component:- KN300734G1, Acot4 gRNA vector 1 in pCas-Guide vector- KN300734G2, Acot4 gRNA vector 2 in pCas-Guide vector- KN300734D, donor vector…

Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14, is an enzyme that in humans is encoded by the PPT2 gene. This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 GRCh38: Ensembl release 89: ENSG00000227600, ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000015474 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: palmitoyl-protein thioesterase 2. Soyombo AA, Hofmann SL (October 1997). Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a ...

Acyl-acyl carrier protein (ACP) thioesterases play an essential role in chain termination during de novo fatty acid synthesis and in the channeling of carbon flux between the two lipid biosynthesis pathways in plants. We have discovered that there are two distinct but related thioesterase gene classes in higher plants, termed FatA and FatB, whose evolutionary divergence appears to be ancient. FatA encodes the already described 18:1-ACP thioesterase. In contrast, FatB representatives encode thioesterases preferring acyl-ACPs having saturated acyl groups. We unexpectedly obtained a 16:0-ACP thioesterase cDNA from Cuphea hookeriana seed, which accumulate predominantly 8:0 and 10:0. The 16:0 thioesterase transcripts were found in non-seed tissues, and expression in transgenic Brassica napus led to the production of a 16:0-rich oil. We present evidence that this type of FatB gene is ancient and ubiquitous in plants and that specialized plant medium-chain thioesterases have evolved independently from ...

Succinyl-CoA is an important intermediate in the citric acid cycle, where it is synthesized from α-Ketoglutarate by α-ketoglutarate dehydrogenase (EC 1.2.4.2) through decarboxylation, and is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (EC 6.2.1.5). Succinyl-CoA may be an end product of peroxisomal beta-oxidation of dicarboxylic fatty acids; the identification of an apparently specific succinyl-CoA thioesterase (ACOT4, EC 3.1.2.3, hydrolyzes succinyl-CoA) in peroxisomes strongly suggests that succinyl-CoA is formed in peroxisomes. Acyl-CoA thioesterases (ACOTs) are a family of enzymes that catalyze the hydrolysis of the CoA esters of various lipids to the free acids and coenzyme A, thereby regulating levels of these compounds. (PMID: 16141203 ...

B: The influence of substrate and products on Them1 dimerization was determined by … Substrate specificities Belinostat molecular weight We next examined the thioesterase activities of Them1 and of THEM1a and THEM1b using acetyl-CoA (Fig. 3A) and palmitoyl-CoA (Fig. 3B) as substrates. Acot12, Them1, THEM1a, and THEM1b each hydrolyzed acetyl-CoA molecules, with values of Km and Vmax (Table 1) for Them1, THEM1a, and THEM1b that were each somewhat higher than for Acot12 (Km = 34.1 �� 2.1 ��M; Vmax = 57.2 �� 4.4 nmol/min/mg). As was the case for Them1, THEM1a and THEM1b exhibited robust thioesterase activity toward palmitoyl-CoA, with similar Km values for each but with Them1 exhibiting a higher value of Vmax compared with THEM1a and THEM1b (Table 1). However, as has been previously reported (18), Acot12 had no appreciable palmitoyl-CoA thioesterase activity (Fig.. 3B). Table 1 also lists for Them1 the steady-state enzymatic constants for a variety of acyl-CoA molecular species. These ...

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...

A few weeks ago, my cinematic team and I had the pleasure of going behind the scenes for the LV2BFIT Valentines Day photo shoot. LV2BFIT is a fashion fitness boutique specializing in active wear and couture accessories located in Rye Ridge Plaza in Rye Brook, New York. Launched by fitness instructor Patty Palmieri, LV2BFIT mixes Pattys passions: fashion and exercise into a unique boutique. The team, the models, and Kris from Ruby Media Group were awesome and a pleasure to work with. Thanks for having us there to film the BTS. Enjoy ...

Acyl-protein Thioesterase Responsible For Depalmitoylation Of Gpa1p; Green Fluorescent Protein (GFP)-fusion Protein Localizes To Both The Cytoplasm And Nucleus And Is Induced In Response To The DNA-damaging Agent MMS

A truly amazing game, Flip2BFit is Fitness Made Fun through fitness activities for kids! This effort to prevent childhood obesity while playing a fitness fun game for kids has become a team effort with our various partners both locally and across the country. Starting with a local organization: CHALK (Choosing a Healthy and Active Lifestyle for Kids - a Not for Profit Organization run by Columbia University Medical Center and the NY Presbyterian community) to Fit to be Kids, Inc. in Southern California that brings fitness fun to low income neighborhoods, Flip2BFit is providing a platform for kids to overcome exercise fears, get up and start moving and all while having fun and getting fit! Fit to be kids implements the board game in to their Saturday morning fitness activities and shares with kids physical activities that help keep them active fit and healthy!Flip2BFit also takes great pride in giving back to help open the minds of children on the other side of the world to what a healthy ...

Expression of ACOT7 (ACH1, ACT, BACH, CTE-II, hBACH, LACH1, MGC1126) in kidney tissue. Antibody staining with HPA025735 and HPA025762 in immunohistochemistry.

Expression of ACOT8 (hACTE-III, hTE, NAP1, PTE-2, PTE1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

I am the owner/instructor at BFitBFree, Body Back Santee, and Santee Stroller Strides. Some of the classes we offer for women: Stroller Strides, Fit4Baby, Body Back, Boot Camp Blast and small group training. I am a military wife who enjoys spending most of my time with my amazing toddler son- Jude! I also LOVE anything to do with fitness and nutrition. I feel so lucky to have a job where I can help women meet their fitness goals and show them how to maintain a healthy lifestyle for life! I am a pre/post natal specialist-certified in Stroller Strides (ACE), Fit4Baby (ACE), Body Back (ACE), Group Fitness Instructor (AFAA ...

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TY - JOUR. T1 - Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity. AU - Soyombo, Abigail A.. AU - Hofmann, Sandra L.. PY - 1997. Y1 - 1997. N2 - Palmitoyl-protein thioesterase is a lysosomal hydrolase that removes long chain fatty acyl groups from modified cysteine residues in proteins. Mutations in this enzyme were recently shown to underlie the hereditary neurodegenerative disorder, infantile neuronal ceroid lipofuscinosis, and lipid thioesters derived from acylated proteins were found to accumulate in lymphoblasts from individuals with the disorder. In the current study, we describe the cloning and expression of a second lysosomal thioesterase, palmitoyl-protein thioesterase 2 (PPT2), that shares an 18% identity with palmitoyl-protein thioesterase. Transient expression of a PPT2 cDNA led to the production of a glycosylated lysosomal protein with palmitoyl-CoA hydrolase ...

Abstract: Thioesterases catalyze the cleavage of thioester bonds within many activated fatty acids and acyl-CoA substrates. They are expressed ubiquitously in both prokaryotes and eukaryotes and are subdivided into 25 thioesterase families according to their catalytic active site, protein oligomerization, and substrate specificity. While many of these enzyme families are well characterized in terms of function and substrate specificity, regulation across most thioesterase families is poorly understood. Here, we characterized a TE6 thioesterase from the bacterium Neisseria meningitidis. Structural analysis with X-ray crystallographic diffraction data to 2.0 Å revealed that each protein subunit harbors a hot dog fold and that the TE6 enzyme forms a hexamer with D3 symmetry. An assessment of thioesterase activity against a range of acyl-CoA substrates revealed greatest activity against acetyl-CoA, and structure-guided mutagenesis of putative active site residues identified Asn-24 and Asp-39 as ...

Rabbit monoclonal antibody raised against a human ACOT7 peptide using ARM Technology. A synthetic peptide of human ACOT7 is used for rabbit immunization.Customer or Abnova will decide on the preferred peptide sequence. (H00011332-K) - Products - Abnova

Perform reliable qPCR with Bio-Rads pre-validated Acot2 primer pair, for the Rat genome. Designed for SYBR Green-based detection.

Human (Homo sapiens) のTHEM6 (thioesterase superfamily member 6)遺伝子を含むベクター、レンチウイルス、アデノウイルス、 (AAV) アデノ随伴、アデノ随伴ウイルス、MMLV レトロウイルス,、piggyBac, shRNA、gRNA、 ガイドRNA、 CRISPR-Cas9 、クリスパー、プラスミド

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Drosophila melanogaster Lacking the Lysosomal Enzyme Palmitoyl-Protein Thioesterase 1 Accumulate Aberrant Ultrastructural Deposits in the Form of Laminar Cytoplasmic Bodies - Volume 11 Issue S02 - A J Hickey, J G Ault, C A Korey, M E MacDonald, R L Glaser

1EXW: Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride.

Definition : Molecular assay reagents intended to identify mutations in the palmitoyl-protein thioesterase 1 (PPT1) gene, located at chromosome 1p32, which encodes for a glycoprotein that removes palmitate groups from cysteine residues in lipid-modified proteins. This genetic mutation has been identified in patients with neuronal ceroid-lipofuscinosis (CLN).. Entry Terms : PPT1-Related Neuronal Ceroid-Lipofuscinoses Gene Mutation Reagents , Neuronal Ceroid-Lipofuscinoses (NCL) Gene Mutation Reagents , Ceroid Lipofuscinosis Gene Mutation Reagents , PPT1 Gene Mutation Detection Reagents , Reagents, Molecular Assay, Gene Anomaly, Mutation, PPT1. UMDC code : 24915 ...

Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.

Background: Mitochondrial acyl-CoA dehydrogenase family member 9 (ACAD9) is essential for the assembly of mitochondrial respiratory chain complex I. Disease causing biallelic variants in ACAD9 have been reported in individuals presenting with lactic acidosis and cardiomyopathy. Results: We describe the genetic, clinical and biochemical findings in a cohort of 70 patients, of whom 29 previously unpublished. We found 34 known and 18 previously unreported variants in ACAD9. No patients harbored biallelic loss of function mutations, indicating that this combination is unlikely to be compatible with life. Causal pathogenic variants were distributed throughout the entire gene, and there was no obvious genotype-phenotype correlation. Most of the patients presented in the first year of life. For this subgroup the survival was poor (50% not surviving the first 2 years) comparing to patients with a later presentation (more than 90% surviving 10 years). The most common clinical findings were cardiomyopathy ...

Background: Mitochondrial acyl-CoA dehydrogenase family member 9 (ACAD9) is essential for the assembly of mitochondrial respiratory chain complex I. Disease causing biallelic variants in ACAD9 have been reported in individuals presenting with lactic acidosis and cardiomyopathy. Results: We describe the genetic, clinical and biochemical findings in a cohort of 70 patients, of whom 29 previously unpublished. We found 34 known and 18 previously unreported variants in ACAD9. No patients harbored biallelic loss of function mutations, indicating that this combination is unlikely to be compatible with life. Causal pathogenic variants were distributed throughout the entire gene, and there was no obvious genotype-phenotype correlation. Most of the patients presented in the first year of life. For this subgroup the survival was poor (50% not surviving the first 2 years) comparing to patients with a later presentation (more than 90% surviving 10 years). The most common clinical findings were cardiomyopathy ...

Ppt1 - Ppt1 (Myc-DDK-tagged) - Mouse palmitoyl-protein thioesterase 1 (Ppt1) available for purchase from OriGene - Your Gene Company.

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Numerous proteins undergo modification by palmitic acid (S-acylation) for their biological functions including signal transduction, vesicular transport and maintenance of cellular architecture. Although palmitoylation is an essential modification, these proteins must also undergo depalmitoylation for their degradation by lysosomal proteases. Palmitoyl-protein thioesterase-1 (PPT1), a lysosomal enzyme, cleaves thioester linkages in S-acylated proteins and removes palmitate residues facilitating the degradation of these proteins. Thus, inactivating mutations in the PPT1 gene cause infantile neuronal ceroid lipofuscinosis (INCL), a devastating neurodegenerative storage disorder of childhood. Although rapidly progressing brain atrophy is the most dramatic pathological manifestation of INCL, the molecular mechanism(s) remains unclear. Using PPT1-knockout (PPT1-KO) mice that mimic human INCL, we report here that the endoplasmic reticulum (ER) in the brain cells of these mice is structurally abnormal. ...

TY - JOUR. T1 - Interdomain Communication between the Thiolation and Thioesterase Domains of EntF Explored by Combinatorial Mutagenesis and Selection. AU - Zhou, Zhe. AU - Lai, Jonathan R.. AU - Walsh, Christopher T T.. N1 - Funding Information: This research was supported by the National Institutes of Health (AI042738, GM020011, and GM047467). J.R.L. is supported by a post-doctoral fellowship from the Helen Hay Whitney Foundation. We thank Michael Fischbach, Ellen Yeh, and Hening Lin for helpful discussion and critical reading of this manuscript. PY - 2006/8. Y1 - 2006/8. N2 - Thiolation (T) domains are protein way stations in natural product assembly lines. In the enterobactin synthetase, the T domain on EntF is recognized in cis by its catalytic partners: the EntF condensation (C), adenylation (A), and thioesterase (TE) domains. To assess surface features of the EntF T domain recognized by C, A, and TE, regions of the EntF T domain were submitted to shotgun alanine scanning and Ent production ...

PPT1, codes Palmitoyl-protein thioesterase, a small glycoprotein that removes palmitate groups from cysteine residues in lipid-modified proteins. Mutations cause neuronal Ceroid lipofuscinosis type 1. There are at numerous disease causing SNPs identified. ...

Differences in the time required for complete turnover of the palmitoyl content in the TAG pool mean that 26% of the cytosolic palmitoyl-CoA pool is oxidized in NTG hearts, whereas 8% of palmitoyl-CoA in this pool is oxidized in MHC-PPARα hearts. Nearly 4 times more of the cytosolic palmitoyl-CoA pool in NTG hearts than MHC-PPARα is oxidized during the time required for complete exchange of the palmitoyl-CoA pool with TAG. Thus, faster TAG turnover, and palmitoyl-CoA exchange with TAG, corresponds to a lower percentage of the palmitoyl-CoA pool being oxidized in the same time period. The distinction between the influence of relative rates of palmitate turnover within TAG and palmitate oxidation and the source of palmitoyl-CoA indicates that palmitate preferentially enters the TAG pool before lipolysis and, ultimately, β-oxidation (Figure 6A) in the MHC-PPARα heart. With such rapid turnover, LCFAs enter the cell, are stored, and then, following lipolysis, are finally oxidized. These findings ...

The Ras family of guanosine triphosphatases plays key roles in signaling downstream of growth factors, and mutations in the encoding genes are associated with various types of cancer. All of the proteins are prenylated, and H-Ras, N-Ras, and K-Ras4A (but not K-Ras4B) are also palmitoylated at the Golgi and depalmitoylated at the plasma membrane. Indeed, the palmitoylation status of the proteins controls their cellular localization, with palmitoylation promoting transport to the plasma membrane and depalmitoylation returning Ras to the Golgi to reinitiate the cycle. Ahearn et al. show that the prolyl isomerase FKBP12 (named for its ability to bind the immunosuppressive agent FK506 that binds and inhibits this protein; see Liu et al.) bound to palmitoylated Ras isoforms and promoted their depalmitoylation and thus their trafficking to the Golgi. The authors noticed that a green fluorescent protein (GFP) fusion construct with only 10 amino acids of the H-Ras C-terminal tail (GFP-H-Ras10aaTail) ...

Lixia Jia, Mariangela Chisari, Mohammad H. Maktabi, Courtney Sobieski, Hao Zhou, Aaron M. Konopko, Brent R. Martin, Steven J. Mennerick and Kendall J. Blumer; 2014 Journal of Biological Chemistry, 289(9) pp. 6249-57

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15260498] The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. (Biochemistry. , 2004 ...

THEM6_HUMAN RecName: Full=Protein THEM6; AltName: Full=Mesenchymal stem cell protein DSCD75; AltName: Full=Thioesterase superfamily member 6; Flags: Precursor ...

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