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TY - JOUR. T1 - Comparative pharmacokinetics of ampicillin trihydrate, gentamicin sulphate and oxytetracycline hydrochloride in Nubian goats and desert sheep. AU - Elsheikh, H. A.. AU - Osman, I. A.. AU - Ali, B. H.. PY - 1997. Y1 - 1997. N2 - In this investigation the pharmacokinetics of three commonly used antibiotics, ampicillin trihydrate (10 mg/kg), gentamicin sulphate (3 mg/kg) and oxytetracycline hydrochloride (5 mg/kg), given intravenously, were each studied in five Nubian goats and five desert sheep. The pharmacokinetic parameters were described by a two-compartment open model. The results indicated that there were significant differences between the two species in some kinetic parameters of ampicillin and oxytetracycline but not gentamicin, Ampicillin elimination halflife (t( 1/4 β)) in goats (1.20 h) was shorter than that in sheep (2.48 h), and its clearance (Cl) significantly higher in goats (2921 mL/h · kg) compared to sheep (262 mL/h · kg) (P ,0.01). Ampicillin volume of ...
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The pharmacokinetics of conventional and long-acting oxytetracycline (OTC), widely used antibacterial drugs in veterinary medicine with a broad spectrum, were evaluated in Kilis goats at single dosage of 20 mg-kg-1 body weight (bw). A total of 21 goats were divided into three groups: Intravenous (IV) (Group I) and intramuscular (IM) (Group II) administration of the conventional formulation and IM administration of the long-acting formulation (Group III). Blood samples were taken at 0.25, 0.5, 1, 2, 4 8, 12, 24, 36, 48, 60, 72 and 96 hours; where OTC analysis was performed by HPLC. For Group III, and Group II, time to reach maximal plasma drug concentration (Tmax) were 0.6±0.28 and 0.46±0.09 hours and maximal plasma drug concentrations (Cmax) were 8.72±2.47 µg/ml, 13.57±5.83 µg/ml, respectively. In Group I, C0 concentration was found as 63.51±11.59 µg/ml. The elimination times (T1/2) were 10.84±3.20, 27.96±11.66 and 10.47±1.30 hours; and AUC were 115±29.12 µg/ml/h, 96.44±9.49 µg/ml/h and
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Coloured scanning electron micrograph (SEM) of Streptomyces rimosus, Gram-positive, aerobic, filamentous, rod prokaryote (bacterium). Streptomyces sp. belongs to the Actinomycetes group and are bacteria that share many characteristics with fungi. They grow usually as filaments (chains of cells) and often branch to form a network of filaments (mycelium) in the soil. These soil bacteria are responsible for the musty odour of soil. Streptomyces rimosus is notably the most characterized industrial streptomycete producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and non-infective diseases. Magnification: x2,400 when shortest axis printed at 25 millimetres. - Stock Image C032/2096
Coloured scanning electron micrograph (SEM) of Streptomyces rimosus, Gram-positive, aerobic, filamentous, rod prokaryote (bacterium). Streptomyces sp. belongs to the Actinomycetes group and are bacteria that share many characteristics with fungi. They grow usually as filaments (chains of cells) and often branch to form a network of filaments (mycelium) in the soil. These soil bacteria are responsible for the musty odour of soil. Streptomyces rimosus is notably the most characterized industrial streptomycete producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and non-infective diseases. Magnification: x2,400 when shortest axis printed at 25 millimetres. - Stock Image C032/2097
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A simple, rapid and specific ion-pair liquid chromatographic method for the routine determination of the marker residue of oxytetracycline in sheep milk, at levels as low as 20 microg/kg, has been developed. Milk samples were acidified and extracted with acetonitrile. The extracts were purified by treatment with ammonium sulphate and concentrated into diluted phosphoric acid. Separation was carried out isocratically on a Nucleosil C(18) column using a mobile phase that contained both positively and negatively charged pairing ions. The in-house validated method gave overall recoveries and overall relative standard deviations better than 86% and 4.6%, respectively. The method was successfully applied to study the depletion of oxytetracycline in sheep milk and to estimate the withdrawal period after intramuscular administration of a commercial oxytetracycline formulation.
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Composition: Each ml contains: Oxyteracycline. 200mg Pharmacological actions and indications: Oxytetracycline is broad spectrum antibiotic with bacteriostatic activity against a wide variety of micro-organisma, for cattle, swine, sheep, goats and poultry. Indications: In cattle: Diphtheria, anthrax, bacterial enteritis, footrot, anaplasmosis, leptospirosis, metritis, pneumonia, wound infection and shipping fever. In horses: Upper respiratory infections, strangles, peritonitis, fistula of the withers, foaling paralysis, wound infections, phlegmon, thrush and joint infections. Sheep and goats: Pneumonia joint infection, wound infections, bacterial enteritis. In layers: Coryza, fowl cholera, infectious sinusitis, infectious synovitis, chronic respiratory diseases and airsacculitis. Route of administration: Oxytetracycline is administered by intramuscular and intravenous routes. In all animals except layers where it is administered only intramuscularly. Dosage: The dose of
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Fifty-four Holstein cows with retained fetal membranes on a single 1,400-cow commercial dairy were used in this study. Cows were treated once a day with 5 g of oxytetracycline by intrauterine infusion for at least 2 days, or until the membranes were expelled. Cows that became clinically ill (fever and off-feed) were also given procaine penicillin G at 20,000 IU/kg (9,000 IU/lb) of body weight, IM daily for 2 to 4 days. Milk samples were collected at 24-hour intervals during treatment, and at 12-hour intervals after the last treatment. All samples were frozen and submitted every 2 weeks for high performance liquid chromatography (HPLC) analysis for oxytetracycline ...
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Previously, Adams and coworkers (1) reported the localization of Tet A on an EcoRI restriction fragment approximately 5.4 kb in size in OTr plasmids (pASOT plasmids) from Scottish isolates of A. salmonicida(recovered after furunculosis outbreaks). These workers also showed that OTr-encoding plasmid pRAS1 (originally discovered inA. salmonicida isolated from Atlantic salmon with furunculosis in a fish farm near Bergen, Norway; R.-A. Sandaa, personal communication) carried Tet A on the same fragment. Plasmid pRAS1 has also been shown to possess the IncU replicon (R.-A. Sandaa, A. G. Eide, K. Y. Mazengia, B. K. Thorsen, and Ø. Enger, First Symp. EU-Concerted Action Mobile Elements Contrib. Bacterial Adaptability Diversity (MECBAD), p. 84, 1998) and to be closely related to the pASOT plasmids (based upon RFLP assessments, antibiotic resistances, and transfer frequencies; 1). It was not established whether the pASOT plasmids also contained the IncU replicon. However, it was suggested that the Tet A ...
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The product is orally administered, in the fodder or in the drinking water, this way:. Swine: 50-150 g product/100 l water (10-30 mg chlor-hydrate oxytetracycline/kg g.c.), or 0,5 - 3kg product/ fodder tone, once a day, for 5 days.. Calves, lambs, kids, colts: 1 - 1.5 g product/ 10 kg body weight, (20 - 30 mg chlor-hydrate oxytetracycline /kg body weight). It is daily administered in the fodder or in the drinking water, for 5 consecutive days.. Dogs, cats, rabbits, minks: 2,5 g product/ 10 kg g.c. (50 mg chlor-hydrate oxytetracycline/ kg g.c.), divided in 2 doses, for 5 consecutive days.. Poultry (broiler chickens, hens, turkey hens, ducks, geese): 50-150 g product/100 l water (10-30 mg chlor-hydrate oxytetracycline/kg g.c.), or 1 - 2 kg powder for one fodder tone (20 - 40 mg chlor-hydrate oxytetracycline/ kg g.c.), once a day, for 5 consecutive days.. Fish: 20 - 30 g product / 100 kg fish, daily. For the adult fish, the product is administered in one dose, and for the young, the product is ...
Toxicology and carcinogenesis studies were conducted on oxytetracycline hydrochloride (greater than 98.8% pure), a broad-spectrum antibiotic. Groups of F344/N rats and B6C3F1 mice were fed diets containing oxytetracycline hydrochloride for a series of 14-day, 13-week, and 2-year studies. In the 14-day studies, no compound-related gross pathologic effects were seen in rats or mice (groups of five animals per sex per species) given up to 100,000 ppm in their feed. The final mean body weight of male rats receiving in feed was 27% lower than that of the controls. Final mean body weights of mice that received 25,000, 50,000, or 100,000 ppm were lower (male: 11%; 16%; 17%; female: 6%; 5%; 17%) than those of the controls. In the 13-week studies, groups of 10 male and 10 female rats and mice were fed diets containing up to 50,000 ppm in feed, and no chemically related gross or histopathologic effects were observed in mice of either sex or in female rats. In male rats, fatty metamorphosis of minimal ...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Two formulations of tetracycline, N-pyrrolidinomethyl tetracycline and oxytetracycline hydrochloride, were tested for their efficacy by high-pressure or syringe injection on cherry trees affected with buckskin disease and by high-pressure, syringe injection or gravity bag infusion on peach trees affected with yellow leafroll (PYLR). The trees were treated in August 1983 and evaluated before harvest in 1984. The disease rating of cherry trees affected with buckskin disease was reduced from severe to mild by both antibiotic formulations when 4 g a.i. was injected per tree, providing economic control. When peach trees affected with PYLR were injected with 2 g a.i. of antibiotic per tree, the average disease rating of the trees was reduced from severe to moderate by high-pressure injection, syringe injection, and gravity bag infusion of both formulations. No significant differences in efficacy were found between the two tetracycline formulations or between the method of application in either cherry ...
Mycoplasma is very difficult to treat because many commonly used antibiotics do not work well. Penicillin, Polyflex®, Naxcel®, Excenel®, and Excede® kill bacteria by destroying the cell wall. Since Mycolplasma does not have a normal cell wall, these antibiotics are ineffective in treating it. Micotil® shows little or no activity against Mycoplasma as well.. Oxytetracycline (the active ingredient in LA-200®, Biomycin 200®, Tetradure 200®, and other generics) has produced mixed results in treating Mycoplasma. In one study 50 percent of M. bovis isolates were resistant to oxytetracycline. Tulathromycin (Draxxin®) is the only drug approved for Mycoplasma, and in one study, was the drug most likely to be effective (Godinho, et al., 2005). Draxxin® provides the most convenient treatment of Mycoplasmosis because one dose provides seven to 14 days of therapeutic blood concentrations against Mycoplasma and Mannheimia haemolytica, Pasturella multocida, and Histophilus somni, all causes of BRDC. ...
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This study was conducted on 54 Iraqi buffaloes out of 136 buffaloes suffered from partial or complete uterine prolapse (44 buffaloes) after parturition directly, during 12 hrs postpartum or12-24 hrs postpartum and 10 Iraqi buffaloes out of 54 without uterine prolapse considered as comparative group, aged between 3-8 years old in Babylon province/ AL.Qassim city in period from 2011-2013.The affected animal were divided randomly into four groups according to the period of involution of uterus after parturition and the suitable treatment which for this period. Group1 (G1)consist of 18 buffaloes treated directly after parturition by low epidural anesthesia and replacement of the prolapse uterus followed by washing with warm distal water and lubrication with local antibiotic and systemic antibiotic (Oxytetracycline20% 4mg.)20ml/I.M. . Group2(G2) (16 buffaloes) they were treated by low epidural anesthesia and prolapsed uterus supported by a towel and sprinked with 40% glucose and suturing vulva after ...
More than a year ago now I was diagnosed with perioral dermatitis and promptly prescribed the antibiotic oxytetracycline which has since worked wonders for it and kept it at bay. I was a little concern...
Water fluoridation is compulsory mass medication, in breach of human rights, the Supreme Court has ruled by a majority vote. It confirmed that fluoridation is a medical treatment as claimed by opponents for over 60 years. It is not a supplement just topping up natural levels, as claimed by the Ministry of Health.. The impracticality of avoiding fluoridated water makes it compulsory in practice, the majority also ruled.. Three judges held that there was conflicting scientific evidence, confirming that the science is NOT settled.. Chief Justice Sian Elias then held that fluoridation was not prescribed by law, applying section 6 of the Bill of Rights Act, and was therefore unlawful as it breached section 11. That was the correct decision in Fluoride Free NZs view.. The rest of the majority held that it was prescribed by law, and it was then necessary to apply a balancing test to determine if the breach of the right - not to be subject to medical treatment without consent - was justified in the ...
The literature examining the impact of antimicrobial use in food animals on the development of resistance is not large but is consistent with what would be anticipated by extrapolating from resistance studies performed with human populations. Levy et al28 examined the effect of chlortetracycline in feed on the intestinal flora of chickens and farm dwellers. Using a controlled experimental design, chickens were divided into 2 groups: the experimental group received feed that contained subtherapeutic doses of oxytetracycline, and the control group received feed without the drug. After 2 weeks, 90% of the experimental chickens excreted 100% resistant organisms. Multidrug resistance developed as well (resistance to sulfonamides, streptomycin, ampicillin, and carbenicillin); by 12 weeks, almost two thirds of the experimental chickens excreted organisms that were resistant to more than tetracycline, and greater than one quarter were resistant to all 4 antimicrobials. Chickens in the control group, ...
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Estimation of adsorption/desorption Freundlich´s affinity coefficients for oxytetracycline and chlortetracycline from soil properties: Experimental data and pedotransfer functions ...
The long-term effects of a single dose of meloxicam (Metacam 20mg/ml; Boehringer Ingelheim Vetmedica) in conjunction with antibiotic therapy in cattle with clinical signs of bovine respiratory disease (BRD) was evaluated in a blind, controlled, randomised study. Two hundred animals with clinical signs of BRD received a single subcutaneous injection of 20 mg/kg oxytetracycline; 100 of them also received a subcutaneous injection of 0·5 mg/kg meloxicam, and the other 100 received an injection of isotonic saline. The animals were weighed before they were treated and seven, 35, 70 and 105 days later, and finally before they were slaughtered. The mean bodyweight of the meloxicam-treated animals was significantly higher from day 70 until slaughter, and the mean average daily weight gain until slaughter and the mean carcase weight of the animals treated with meloxicam were significantly higher. In the animals with lung lesions, significantly less lung tissue was affected in those that had been treated ...
Azotaemia Aggravated by Tetracycline: Oxytetracycline given to two patients with impaired renal function produced clinical deterioration and increasing azotaemi
Indications :. Used for the treatment and control of foot rot, digital dermatitis, udders teat, lip and all skin infections, skin burns, post surgical infections and excoriations caused by Oxytetracycline sensitive organisms in cattle, sheep and all animal species ...
Titre du document / Document title Isolation of doxycycline, 6-epidoxycycline and 2-acetyl-2-decarboxamidometacycline from commercial metacycline by preparative colum.A simple HPLC method for the separation of doxycycline and its degradation products 6-epidoxycycline and metacycline was developed.. high selectivity for tetracycline over the other structurally related tetracycline derivatives (oxytetracycline and doxycycline) in a mixture.. ...
August 5, 2005: Food service provider Compass Group is taking a preemptive step in ebbing the flow of antibiotics into the food supply by stipulating new drug usage levels to its processors. Working with Smithfield Foods Inc., the nations leading pork processor, and the nonprofit group Environmental Defense a new policy was laid out in which the corporate caterer refused to purchase pork if the pigs were fed antibiotics approved for human use as growth promoters. Banned antibiotics include penicillin, erythromycin, oxytetracycline and sulfamethazine. The announcement comes on the heals of the Food and Drug Administrations Baytril ban for use in poultry and an increasingly serious concern of antibiotic resistance in humans. The Baytrill ban is the first of its kind for the livestock industry.. For the more go to: ...
The study was conducted on lactating cattle and buffaloes in tehsil Burewala, district Vehari, Pakistan. The purpose of study was to isolate different types of microorganisms associated with mastitis and to see the effectiveness of different antibiotics against these isolates. Relative prevalence of Staphylococcus aureus was the highest (50% and 53.85% in cattle and buffaloes respectively) followed by Streptococcus agalactiae (27.78% and 23.07%), Escherichia coli (16.67% and 15.38%), Streptococcus dysagalactiae (5.55% and 3.85%), and Corynebacterium bovis (0% and 3.85%) in cattle and buffaloes respectively). On the whole, the isolates were sensitive in descending order to Enrofloxacin, Chloramphenicol, Gentamycin, Oxytetracycline, and Amoxicillin ...
Milk and other dairy products should not be taken with medicine Milk or dairy milk taking drugs may affect the therapeutic effect of certain medications. Taking the antibiotics such as tetracycline, oxytetracycline with milk can produce insoluble chelation, significantly weakening the effectiveness of drugs. Whats more, taking some medicine together with milk can even lead to poisoning.. ...
Orally administered drugs may be metabolized by intestinal microbial enzymes before absorption into the blood. Accordingly, coadministration of drugs affecting the metabolic activities of gut microbes (e.g., antibiotics) may lead to drug-drug interactions (DDI). In this study, gut microbiota-mediated DDI were investigated by studying the pharmacokinetics of lovastatin in antibiotic-treated rats. Incubation of lovastatin with human and rat fecalase preparations produced four metabolites, M1 (demethylbutyryl metabolite), M4 (hydroxylated metabolite), M8 (the active hydroxy acid metabolite), and M9 (hydroxylated M8), indicating involvement of the gut microbiota in lovastatin metabolism. The plasma concentration-time profiles of M8 were compared after oral administration of lovastatin to control rats or those treated with either ampicillin (100 mg/kg) or an antibiotic mixture consisting of cefadroxil (150 mg/kg), oxytetracycline (300 mg/kg), and erythromycin (300 mg/kg). Pharmacokinetic analyses ...
I am originally from Detroit, Michigan. I graduated with honors from the University of South Carolina Aiken in 2019 with a B.S. in biology. My time at USCA was spent on several genetics-based research projects including characterizing the genomic population structure of American Woodstorks (Mycteria americana), developing an mPing-based activation tag for crop insertional mutagenesis, and determining the substrate and metal dependance of a carbon cleaving enzyme. I graduated from Clemson University in 2021 with a Masters degree in Plant Sciences from the laboratory of Dr. Hehe Wang. My thesis focused on characterizing the genetic mechanisms contributing to oxytetracycline and streptomycin resistance in Xanthomonas arboricola pv. pruni, the causal agent of bacterial spot in peach. This project has contributed to a better understanding of the spread and maintenance of antibiotic resistance genes within peach orchards and has facilitated the development of novel management strategies for bacterial ...
This is the generic version of LA-200, the oxytetracycline, broad spectrum antibiotic for use in treating respiratory infection/pneumonia, mastitis, pinkeye, scours, and shipping fever. Do not use milk for food for 96 hours after last treatment. Do not u
Hatchery-reared walleyes have played an important role in rehabilitation of Great Lakes walleye populations. For example, stocking efforts to rehabilitate remnant walleye populations in northern Green Bay, Lake Michigan began in 1969, after populations nearly collapsed. Some natural reproduction was documented as early as 1988, but no quantitative data existed for assessing contributions of hatchery- and naturally-produced fish. This data gap and the changing environment of northern Green Bay have hindered efforts to define the extent of population recovery and the future role of hatchery fish. We used oxytetracycline (OTC) marking to determine the relative contribution, growth, and survival of stocked walleyes for the 2004-9 year classes of walleyes in Little and Big bays de Noc in northern Green Bay. Marking study results, combined with spatial information on juvenile walleye abundance and historic harvest data, provide insight into the past, present, and future walleye management potential of ...
Antibacterial natural products not only have provided a bonanza of molecules for medicinal chemistry, but they also have played a pivotal role in the growth of biological chemistry as a discipline. Today, natural products continue to present fundamental and translational challenges at the chemistry-biology interface, such as in understanding the diverse nature of antibiotic synthesis. This theme is explored in a recent Journal of Biological Chemistry thematic minireview series that offers four reviews that discuss insights into the biosynthesis of four distinct antibiotics: daptomycin, oxytetracycline, erythromycin and thiopeptides. On the other side of the coin is the subject of a second JBC minireview series: influenza viruses. These viruses are grouped into three types, A, B and C, but within each group, specific virus strains still can run a broad spectrum in their virulence and pathogenicity. To fully understand what factors influence this spectrum, one needs detailed information about ...
Human gamma globulin when administered intraperitoneally to mice challenged by a lethal intracerebral staphylococcal infection, enhanced the protective action of penicillin and oxytetracycline. This fact, added to the previously described antistaphylococcal action of human gamma globulin used in experimental and human infections suggest that human gamma globulin could be tried with some success as a preventive agent in human groups particularly exposed to staphylococcal infection, such as the prematurely born babies.. ...
Update on our dog who was very unwell with an unknown illness with our vet possibly going down the lines of an exocrine pancreatic insufficiency or Addisons disease and the last time I spoke about it in these notes we were being referred to the vet school in Glasgow. Xrays were performed and ultra sound with a full work up of bloods with special tests being carried out at Cambridge, so it did take a while to get all the results but everything has come back clear with only a lower level of protein in the biochem results. Good news that it is not the above however we are still puzzled about what could be wrong. A months course of metronidazole and Oxytetracycline has certainly improved things with the diarrhoea now stopped and with weight gain and an improved coat he is certainly looking better , but still under weight. His background is that Sarah my wife wanted a dog to work in obedience and we lost our last Border collie many years ago and a friend had just happened to text me to say that she ...
1. Pijpers A, Schoevers EJ, van Gogh H, van Leengoed LAMG, Visser IJR, van Miert ASJPAM, Verheijden JHM. The influence of disease on feed and water consumption and on pharmacokinetics of orally administered oxytetracycline in pigs. J Anim Sci. 1991;69:2947-2954.. 2. Keck G, Borne PM. Nouvelles conceptions en antibiothérapie et leurs applications pratiques en médecine vétérinaire. Revue Med Vet. 1995;146:309-320.. 3. Wages D. Volumetric versus mg/kg dosing in poultry. Proc 44th N Cent Avian Dis Conf Symp Poultry Ther. 1993; Columbus Ohio: 22-24.. 4. Sutter HM, Wanner M. Futterzubereitung und pharmacokinetik von chlortetracyclin beim ferkel. Schweitz Arch Tierheilk., 1990;132:175-181.. 5. Gibaldi M. Gastrointestinal absorption--Biologic considerations. In: Gibaldi M, ed. Biopharmaceutics and Clinical Pharmacokinetics. 4th ed. Malvern, Pennsylvania: Lea & Febiger. 1991; 24-39.. 6. Wanner M, Walker W, Sutter HM, Riond JL, Broz J. Influence of dietary citric acid and calcium on the ...
Buy Duphacycline Aerosol at Chemist Direct which is used for the treatment of foot rot in sheep and topical infections caused by oxytetracycline sensitive organisms in cattle and pigs.
Typically, cases of anaplasmosis increase in late summer and fall as insect vectors increase. Therefore, control of vectors is key to preventing anaplasmosis. If necessary herd treatment with oxytetracycline injection every 3 to 4 weeks during high risk times may be necessary will prevent clinical disease but animals can become carriers ...
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