To conduct this study, Dr. Rocca and colleagues followed women who had undergone unilateral or bilateral ovariectomy between 1950 and 1987 while residing in Olmsted County, Minn., home of Mayo Clinic. All of these women had the surgery prior to menopause and for reasons other than cancer. The study evaluated 1,293 women with unilateral ovariectomy, 1,097 women with bilateral ovariectomy and, for comparison, 2,390 women who had not undergone ovariectomy. All women were followed until their deaths or until the end of the study, which was staggered between 2001 and 2006, via a combination of interviews with the women or a surviving relative, medical records and death certificates. A unique strength of this study, according to the investigators, was a 25- to 30-year median follow-up time. A total of 1,292 ...
Fingerprint Dive into the research topics of Growth hormone protects against ovariectomy-induced bone loss in states of low circulating Insulin-like Growth Factor (IGF-1). Together they form a unique fingerprint. ...
Rationale: There is a special role for estrogens in preventing and curing cardiovascular disease in women. Soy isoflavone (SI), a soy-derived phytoestrogen, is a group of biologically active plant substances with chemical structures which are similar to that of an endogenous estrogen-estradiol.. Objective: We ought to elucidate possible mechanism of SI to improve myocardial ischemia/reperfusion (MI/R) injury in ovariectomized rats.. Methods and Results: Female SD rats were underwent bilateral ovariectomy or sham ovariectomy. One week later, rats were randomly divided into several groups and began to feed soy-free chow: sham ovariectomy operation (control group), ovariectomy with MI/R or ovariectomy with sham MI/R. Other ovariectomy rats were given different doses of SI dissolved in 0.5% carboxymethycellulose (CMC-Na) by gavage. Additional ovariectomy rats were administrated with the same volume of CMC-Na by gavage or 50 μg/kg·d of 17β-estradiol (E2) by subcutaneous injection. After four-week ...
Madularu D, Athanassiou M, Yee JR, Kenkel WM, Carter CS, Mumby DG (2014) Oxytocin and object preferences in the male prairie vole. Peptides. [PubMed] [Content]. Madularu D, Athanassiou M, Yee JR, Mumby DG (2014) Centrally-administered oxytocin promotes preference for familiar objects at a short delay in ovariectomized female rats. Behav Brain Res 274C:164-167. [PubMed] [Content]. Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG (2014) Retrograde and anterograde memory following selective damage to the dorsolateral entorhinal cortex. Neurobiol Learn Mem 116C:14-26. [PubMed] [Content]. Gervais NJ, Jacob S, Brake WG, Mumby DG (2014) Modulatory effect of 17-beta estradiol on performance of ovariectomized rats on the Shock-Probe test. Physiol Behav 131:129-135. [PubMed] [Content]. Gervais NJ, Jacob S, Brake WG, Mumby DG (2013) Systemic and intra-rhinal-cortical 17-beta estradiol administration modulate object-recognition memory in ovariectomized female rats. Horm Behav 64:642-652. [PubMed] ...
The present study was designed to test the effect of acute endogenous estrogen deprivation on endothelium-dependent vasodilation in women in reproductive age. Therefore, in a group of female patients who underwent bilateral ovariectomy for uterine leiomyoma, we evaluated the forearm vascular response to acetylcholine and sodium nitroprusside, an endothelium-dependent and -independent vasodilator, respectively. As control subjects we selected healthy women well matched with the study group population for demographic and clinical parameters. Particular attention was paid to risk factors impairing endothelial function such as age, blood pressure, phase of the menstrual cycle, lipid and glucose profile, and smoking history. In the two study populations, the response to acetylcholine and sodium nitroprusside was similar, indicating preserved endothelium-dependent vasodilation in patients with leiomyoma. In contrast, after bilateral ovariectomy, the response to acetylcholine was found to be reduced ...
The vascular consequences of estrogen treatment may be driven by its initiation timing. We tested the hypothesis that the duration of ovarian hormone deprivation before estrogen reintroduction affects the role of estrogen as mediator of endothelial f
To investigate the role of sex steroids in sex differences in the response of rats to the potent inflammatory mediator bradykinin (BK), we evaluated the effect of sex steroid manipulation on the magnitude of BK-induced synovial plasma extravasation (PE). The magnitude of BK-induced PE is markedly less in females. Ovariectomy of female rats increased BK-induced PE, and administration of 17beta-estradiol to ovariectomized female rats reconstituted the female phenotype. Castration in male rats decreased BK-induced PE, and administration of testosterone or its nonmetabolizable analog dihydrotestosterone reconstituted the male phenotype. The results of these experiments strongly support the role of both male and female sex steroids in sex differences in the inflammatory response. Because the stress axes are sexually dimorphic and are important in the regulation of the inflammatory response, we evaluated the contribution of the hypothalamic-pituitary-adrenal and the sympathoadrenal axes to sex differences in
6221 8457627 / +6221 8458258 [email protected] ABSTRACT. Backgroud: Cognitive function impaired in the elderly is not a disease but it can be considered as a Preclinical Alzheimers Disease (AD) one of the most common dementia in the elderly. Results of research on tempe and tofu showed the effects on different cognitive functions. The aims of this study were to analized the effect of tempe and tofu flours cognitive function in ovariectomized female rats. Method: Seventy two (72) white female Sprague Dawley strain rats, aged 12 months used for this study. Before the intervention 52 rats had ovariectomy (OVx) surgical treatments and were grouped into 5 intervention groups: tempe flour, tofu flour, estradiol, casein; and non ovariectomy. Cognitive function was measured using a labyrin. Processing and data analysis, used One-Way ANOVA with Polynomial Contrass Post Hoc LSD. Results: Based on difference test between the tempe flour group (8 weeks) with baseline 2(after OVx) showed that increased ...
Rodent ovariectomy is an experimental method to eliminate the main source of sexual steroids. This work explored for the first time the ovariectomy temporal changes induced in the hemostatic coa...
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
This study evaluates the effect of hydrolyzed collagen (HC) on bone health of ovariectomized mice (OVX) at different ages. Twenty-six weeks after the OVX procedure, HC ingestion was still able to impr
List of words make out of Ovariectomized. Anagrams and Words made out of Ovariectomized. Find Scrabble Point of Ovariectomized. Definition of Ovariectomized. Puzzle Solver.
Did you know that there is more than one way to spay your dog? Learn about the difference and why your vet might suggest one method over the other.
List of words make out of Oophorectomies. Anagrams of word Oophorectomies. Words made after scrabbling Oophorectomies. Word Creation helps in Anagrams and Puzzles.
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Spaying" and "neutering" are surgical procedures used to prevent pets from reproducing. In a female animal, "spaying" consists of removing the ovaries or uterus and ovaries. The technical term is ovariectomy or ovariohysterectomy. For a male animal, "neutering" involves the removal of the testicles, and this is known as castration.. In addition to preventing unwanted offspring, spaying or neutering has many health and behavioural benefits to the animal.. ...
Doctors give unbiased, helpful information on indications, contra-indications, benefits, and complications: Dr. Jones singer on resume exercise oophorectomy: I dont think one needs to refrain from sexual activity for more than a few days but your eye doctor can give you a better answer. However if you plan to have sex under water, then the answer would be different. :).
Privatklinik Bethanien offers Oophorectomy procedures starting from Price on request and it is specialized in Gynecology treatments.
The brains and bodies of young female rats can be accelerated into puberty by the presence of an older male or by stimulation of the genitals.. 0 Comments. ...
BioAssay record AID 170311 submitted by ChEMBL: Effect on serum cholesterol level as tissue specific estrogen agonist assay in ovariectomized rat model: significant decrease at <10 mg/kg dose.
Patterns of pulsatile luteinizing hormone secretion before and during the onset of puberty in boys: a study using an immunoradiometric assay.: To study spontane
The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-α and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.
The presence of asymmetry in the capacity of the left and right ovaries to secrete testosterone was analyzed by studying the effects of hemiovariectomy along the estrus cycle one hour after surgery. The effects of ether anesthesia on hormone serum levels were also analyzed. Bilateral ovariectomy and the extirpation of the left ovary performed on the day of proestrus resulted in significantly lower testosterone levels. Compared to the anesthetized group, the effects of perforating the peritoneum unilaterally varied according to the day of the estrous cycle and the side of the peritoneum surgery was performed on. Injecting atropine sulfate (ATR) to control or anesthetized rats on D1 resulted in a significant increase of testosterone serum levels. The effects of perforating the peritoneum on testosterone levels depended on the cholinergic innervation and varied along the estrous cycle. Blocking the cholinergic system before performing unilateral or bilateral ovariectomy had different effects depending on
Gonadal steroids are known to influence hippocampal physiology in adulthood. It is presently unknown whether gonadal steroids influence the morphology of hippocampal neurons in the adult intact rat brain. In order to determine whether female sex hormones influence hippocampal morphology in the intact adult, we performed Golgi impregnation on brains from ovariectomized rats and ovariectomized rats which received estradiol or estradiol and progesterone replacement. Removal of circulating gonadal steroids by ovariectomy of adult female rats resulted in a profound decrease in dendritic spine density in CA1 pyramidal cells of the hippocampus. Estradiol replacement prevented the observed decrease in dendritic spine density; progesterone augmented the effect of estradiol within a short time period (5 hr). Ovariectomy or gonadal steroid replacement did not affect spine density of CA3 pyramidal cells or granule cells of the dentate gyrus. These results demonstrate that gonadal steroids are necessary for ...
The majority of cases with ovarian cancer are sporadic, not hereditary. Women with no documented germ line mutation or family history suspicious for genetic risk for ovarian cancer are considered to be at average risk. Women at increased genetic risk for ovarian cancer, especially those with BRCA1 and BRCA2 germ line mutations are at high risk of ovarian cancer and Lynch syndrome, and it is preferred to undergo risk-reducing bilateral salpingo-oophorectomy [10].. Several studies suggest a generally negative health effect when prophylactic bilateral salpingo-oophorectomy is performed before the age of menopause. Bilateral oophorectomy causes immediate drop in hormone levels of ovary that may affect long-term health. Women undergoing bilateral oophorectomy experience vaginal dryness, dyspareunia and loss of libido as a result of abrupt decline in circulating estrogen and testosterone levels [11]. Normally, for many years after menopause ovaries continue to produce androgens which are converted to ...
TY - JOUR. T1 - Circulatory responses to systemic infusions of estrone and estradiol-17α in nonpregnant, oophorectomized ewes. AU - Rosenfeld, Charles R.. AU - Rivera, Richard. PY - 1978/10/15. Y1 - 1978/10/15. N2 - Uterine arterial blood flow dose-response curves to systemic infusions of either estrone (E1) or estradiol-17α (E2α) were determined in ten oophorectomized, nonpregnant ewes. Maximum uterine blood flow occurred with 5 μg per kilogram of E1 and ≥ 20 μg per kilogram of E2α. Total uterine blood flow measured with isotope-labeled microspheres rose more than tenfold following 30 μg per kilogram of either estrogen, as did blood flow to the myometrium, endometrium, and uterine caruncles (p , 0.05). Distribution of uterine blood flow was unaltered. Cervical and vaginal blood flows increased ten-to twenty-fold with E1 and E2α, while mammary gland blood flow rose 54 and 77 per cent. Significant increases in adrenal and thyroid blood flows were documented. The only significant ...
This study was performed to investigate the impact of autonomic dysfunction of the cardiovascular system and its association with the incidence of mortality in diabetic female rats that underwent ovarian hormone deprivation. In addition, we aimed to study the effects of exercise training, as a nonpharmacologic approach to treating diabetes and ovariectomy induced dysfunctions. Two important insights can be gained from the present study. First, the diabetic OVX rats presented increased autonomic dysfunction and mortality compared with normoglycemic rats. Second, TDO rats showed autonomic function improvement and a lower mortality than SDO rats.. Previous reports12,20 demonstrated that ovarian hormone deprivation in rats increases AP to levels higher than that observed in intact female and male rats.12,20-23 The AP values obtained in the SO rats in the present study were also increased in relation to the values documented in previous studies in intact female or male rats. Similarly, the incidence ...
Results μCT analysis of the distal femur metaphysis showed that bone volume/tissue volume (BV/TV) and trabecular number (Tb.N) were significantly less in the OVX group than in the SHAM group, whereas trabecular separation (Tb.Sp) was significantly greater in the OVX group than in the SHAM group. In the TPTD and ALN group, BV/TV and Tb.N were significantly greater than in the OVX group, whereas Tb.Sp was significantly less than in the OVX group. And in the ALN group, BV/TV and Tb.N were significantly greater than in the TPTD group, but Tb.Sp was no significance.. The 50% withdrawal threshold was significantly lower in the OVX group than in the SHAM group, and it was significantly higher in the TPTD and ALN group than in the OVX group. And the 50% withdrawal threshold was no significance between the TPTD and ALN group.. The expression levels of TNF-α was increased in the OVX group compared with those in the SHAM group. Other cytokines were not increased significantly in the OVX group. In the ...
1-(Morpholinomethyl)-4-phthalimido-piperidindione-2,6 (CG 603) had a greater therapeutic effect than bilateral ovariectomy, estrogen (mestranol, 17α-ethinylestradiol-3-methylether), or androgen (drostanolone propionate, 2α-methyldihydrotestosterone propionate, 2α-MDTP) on 7,12-dimethylbenzanthracene-induced tumors in Sprague-Dawley rats. The antitumor activity of CG 603 was equivalent to hypophysectomy. Combined treatment with CG 603 and ovariectomy or estrogen gave no significant increase in antitumor activity over that with CG 603 alone. The combined treatment with CG 603 and 2α-MDTP showed a significantly higher regression of tumor weight and tumor number than the treatment with CG 603 or 2α-MDTP alone. While CG 603 in higher concentrations decreases the body weight of experimental animals, the combination of CG 603 in lower concentration with the anabolically acting 2α-MDTP increases the body weight of the treated animals. CG 603 probably exerts its antitumor activity primarily via ...
A Chinese herbal preparation, QingE formula (QEF), has been used clinically for treating osteoporosis in postmenopausal women by virtue of its kidney-invigorating function; however, no evidence base links QEF to estrogen replacement therapy. In this study, we undertake a characterization of estrogenic activity of QEF using an in vivo model of ovariectomized (OVX) mice together with in vitro studies with the MCF-7 cells for further molecular characterization. OVX mice were treated intragastrically with QEF at doses of 0.85, 1.7, and 3.4 g/kg per day for 4 weeks. QEF treatments restored the estrus cycle and demonstrated significant estrogenic activity, as indicated by reversal of uterine atrophy (six-fold increase in uterine weight), reduction in rectal temperature, and increased expression (1.6-fold) of estrogen receptors (ERs) in the uterus. Notably, the largest changes in these three parameters were found at the lowest dose. At the highest dose of QEF, significant changes were found in adrenal ...
While there is evidence that sex hormones influence multiple systems involved in salt and water homeostasis, the question of whether sex hormones regulate aquaporin-2 (AQP2) and thus water handling by the collecting duct has been largely ignored. Accordingly, the present study investigated AQP2 expression, localization and renal water handling in intact and ovariectomized (OVX) female rats, with and without estradiol or progesterone replacement. OVX resulted in a significant increase in urine osmolality and increase in p256-AQP2 in the renal cortex at 7 days post-OVX, as well as induced body weight changes. Relative to OVX alone, estradiol repletion produced a significant increase in urine output, normalized urinary osmolality and reduced both total AQP2 (protein and mRNA) and p256-AQP2 expression, whereas progesterone repletion had little effect. Direct effects of estradiol on AQP2 mRNA and protein levels were further tested in vitro using the mpkCCD principal cell line. Estradiol treatment of ...
Female gender, which is abolished following ovariectomy and reproductive senescence, is associated with improved outcome following cerebral stroke. Estrogen replacement partially restores this benefit of the female gender but the effect of progesterone in hormone-deficient animals is currently unknown. We evaluated various outcomes following middle cerebral artery occlusion (MCAO) in ovariectomised female mice, with a physiologically relevant restoration of progesterone levels. Ovariectomised female mice had significantly elevated plasma (P=,0.05) and brain progesterone levels (P=,0.01) following implantation of a 21-day release pellet (50mg) compared with mice that received placebo implants 7 days prior to undergoing 60 min MCAO. Assessment of well-being (body weight recovery) and neurological score at 24h and 48h post-MCAO indicated that MCAO significantly worsened outcome compared with sham-operated mice but progesterone had no effect. MCAO resulted in a substantial lesion formation and a ...
Effect of Ledebouriella seseloides Extracts on Lipid Parameters in Ovariectomized Rats - ALP;collagen;Ledebouriella seseloides;lipid parameters;ovariectomized rats;
M. A. Jackson, Iwaniec, U. T., Turner, R. T., Wronski, T. J., and Kalra, S. P., "Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats.", Peptides, vol. 32, no. 8, pp. 1575-80, 2011. ...
Two experiments of divergent selection for uterine efficiency in rabbits were performed. Rabbit does were unilaterally ovariectomized and a laparoscopy was made at mid-gestation to observe the number of corpora lutea and implanted embryos in the functional genital tract. Selection was based on the number of fetuses which died between implantation and birth in the first experiment, and on litter size in the second one, both using BLUP on an animal model. This paper presents the average values of observed traits and their heritability. Results show that an effective overcrowding of one uterine hom was obtained at implantation. The additive genetic variability of embryonic survival seems to be greater than that of fetal survival. Some differences in heritabilities between intact and unilaterally ovariectomized females tend to appear ...
Sexual dimorphism in blood pressure has been associated with differential expression of the angiotensin II (AII) receptors and with activity of the nervous system. It is generally accepted that ageing affects kidney function as well as autonomic nervous system and hormonal balance. Given that hypertension is more prevalent in men than women until women reach their seventh decade, we hypothesised that females would be relatively protected from adverse effects of ageing compared to males and that this would be mediated by the protective effect of ovarian steroids. Intact and gonadectomised male and female normotensive Wistar rats aged 6, 12 and 18 months were used to study renal function, blood pressure, heart rate, and blood pressure variability. We observed that intact females had lower levels of proteinuria and higher (12.5%) creatinine clearance compared to intact males and that this difference was abolished by castration but not by ovariectomy. Ovariectomy resulted in a change by 9% in heart rate,
Introduction: The quality of life of every individual is influenced by many different factors. For women in menopause, estrogen deficiency is undoubtedly one of these factors. Estrogen deficit leads to a series of symptoms, which may affect their quality of life to some extent. In the clinical practice, it is important to have a tool to assess the quality of life that is practical and is able not only to assess the quality of life. Aim: The aim of the research was to determine whether and to what extent the symptoms of estrogen deficiency occur in women during menopause and how they affect their quality of life. Method: The survey ran from July to October 2016 in a medical facility in Zlín. The research involved 284 women aged 45-60 years who suffered from the symptoms of estrogen deficiency. The incidence and severity of symptoms were assessed using the printed form of the Czech version of the Menopause Rating Scale questionnaire. Results: The respondents reported mostly mild or no problems. ...
ovariectomy: surgical removal of the ovaries; female castration. Dictionary of Sexology Project: Dictionary of Sexology: Main Index|Main In...
Looking for 17-beta estradiol? Find out information about 17-beta estradiol. C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and... Explanation of 17-beta estradiol
This study aimed to examine radiologic microarchitectural changes in the mandibles of ovariectomized (OVX) rats through a systematic review and meta-analysis and to identify factors of the OVX rat model that influence on the bone microstructure. Eligible articles were identified by searching electronic databases, including Embase, Medline, Web of Science, and KoreaMed, for articles published from January 1966 to November 2017. Two reviewers independently performed study selection, data extraction, and quality assessment. The pooled standardized mean difference (SMD) with 95% confidence intervals was calculated using a random-effects model. Subgroup analysis and meta-regression were performed to explore the effect of potential sources on the outcomes. The reliability of the results was assessed by sensitivity analysis and publication bias. Of 1160 studies, 16 studies (120 OVX and 120 control rats) were included in the meta-analysis. Compared to the control group, the OVX rats trabecular bone volume
Hormone therapy (HT) is reported to be deficient in improving learning and memory in older postmenopausal women according to recent clinical studies; however, the reason for failure is unknown. A "window of opportunity" for estrogen treatment is proposed to explain this deficiency. Here, we found that facilitation of memory extinction and long-term depression by 17β-estradiol (E2) was normal in mice 1 week after ovariectomy (OVXST), but it was impaired in mice 3 months after ovariectomy (OVXLT). High-throughput sequencing revealed a decrease of miR-221-5p, which promoted cannabinoid receptor 1 (CB1) ubiquitination by upregulation of Neurl1a/b in E2-treated OVXLT mice. Blood samples from postmenopausal women aged 56-65 indicated decreases of miR-221-5p and 2-arachidonoylglycerol compared with samples from perimenopausal women aged 46-55. Replenishing of miR-221-5p or treatment with a CB1 agonist rescued the impairment of fear extinction in E2-treated OVXLT mice. The present study demonstrates ...
Translation: The null hypothesis holds that estrogen supplementation in postmenopausal women makes no difference with respect to Alzheimers onset. If this null hypothesis were true, then these are the frequencies we would have expected for the various cells of the table, given the marginal totals that appear along the right edge and the bottom of the table.. In case all this calculation and its accompanying jargon are proving a bit confusing, step back for a moment and think of it this way. On the null hypothesis, we would have expected the two categories of subjects those who received estrogen supplementation and those who did not to show approximately the same proportionate incidence of Alzheimers onset during the five-year period. And that is exactly what the calculated values of E are specifying. Thus, of the 156 subjects who did receive estrogen supplementation, we would have expected a 23.18/156=14.9% rate of onset; and for the 968 subjects who did not receive supplementation, we would ...
In Vivo Studies. Systemic inflammation and mortality were induced by intraperitoneal injection of Escherichia coli endotoxin [lipopolysaccharide (LPS)] into wild-type and PARP-1-deficient mice (Liaudet et al., 2000). To induce systemic inflammatory mediator production without mortality, LPS was injected at a dose of 1 mg/kg, followed by the measurement of TNF-α and macrophage inflammatory protein (MIP)-1α at 90 min, using enzyme-linked immunosorbent assay. To inhibit the catalytic activity of PARP in vivo, the phenanthridinone-based PARP inhibitor PJ34 (Jagtap et al., 2002) at 10 mg/kg or INO-1001 (Szabó et al., 2004; Jagtap et al., 2005) at 3 mg/kg were given i.p., as a 30-min pretreatment prior to the injection of LPS.. In some experiments, LPS (1 mg/kg i.p.) was given to ovariectomized female mice in the absence or presence of PARP inhibitor pretreatment (doses as above), followed by measurement of TNF at 90 min. In another set of experiments (in female mice), the dose of LPS was increased ...
Question - What is the treatment for clitoral atrophy caused due to estrogen deficiency?. Ask a Doctor about diagnosis, treatment and medication for Estrogen deficiency, Ask an OBGYN, Gynecologic Oncology
Female subjects must be postmenopausal. Menopause can be assumed to have occurred in a woman when there is either appropriate medical documentation of prior complete bilateral oophorectomy or permanent cessation of previously occurring menses , 12 months as a result of ovarian failure or bilateral oophorectomy with documentation of hormonal deficiency by a certified healthcare ...
Female subjects must be postmenopausal. Menopause can be assumed to have occurred in a woman when there is either appropriate medical documentation of prior complete bilateral oophorectomy or permanent cessation of previously occurring menses , 12 months as a result of ovarian failure or bilateral oophorectomy with documentation of hormonal deficiency by a certified healthcare ...
Flavia de Oliveira, Laura B.M. Maifrino, Gustavo P.P. de Jesus, Juliana G. Carvalho, Cláudia Marchon and Daniel A. Ribeiro). Estrogen deprivation in postmenopausal women increases cardiovascular risk. Cardiovascular risk as a result of atherosclerosis is able to induce an inflammatory disease as far as cyclooxygenase-2 (COX-2) expression. The purpose of the study was to investigate the role of COX-2 on exercise training in female mice LDL-KO with or without ovariectomy. Results showed that ovariectomy induced a strong immunoexpression in atherosclerosis lesion of LDL-KO mice. Nevertheless, a down-regulation of COX-2 expression was detected in LDL-KO trained ovariectomized when compared to LDL-KO sedentary. Our results are consistent with the notion that exercise training is able to modulate COX-2 expression in LDL-KO mice as a result of COX-2 down-regulation.. ...
Using a kinome-wide siRNA screen, we identified the InsR/IGF-IR pathway as a mechanism of escape from hormone dependence in ER+ breast cancer. RNAi-mediated knockdown of InsR and/or IGF-IR inhibited growth of ER+ breast cancer cells adapted to hormone deprivation, but dual knockdown additively suppressed PI3K/AKT signaling. Pharmacologic blockade of InsR/IGF-IR with OSI-906 inhibited PI3K/AKT and LTED cell growth. OSI-906 also prevented the emergence of hormone-independent tumors, and suppressed growth of ER+ xenografts in ovariectomized mice. Blockade of IGF-IR alone was insufficient to prevent emergence of hormone-independent cells or suppress tumor growth, suggesting that dual inhibition of InsR and IGF-IR is necessary to prevent escape of ER+ breast cancer cells from estrogen dependence. Combined inhibition of ER and InsR/IGF-IR suppressed hormone-independent tumor growth more effectively than each intervention alone. Finally, an insulin/IGF-I-induced gene expression signature was predictive ...
Sigma-Aldrich offers abstracts and full-text articles by [Andrea M Stathopoulos, Cleyde V Helena, Ruth Cristancho-Gordo, Arturo E Gonzalez-Iglesias, Richard Bertram].
I know women who decided never to take hormone replacement therapy because of these studies. Some of them have never returned to feeling as well as they did pre-menopause. Others, it doesnt seem to bother much. I suspect there is considerable individual physiological variability associated with the number of estrogen receptors and such, which probably determines how sensitive one is to estrogen depletion. But it is an individual thing, and each individual should decide for themselves whether the risk is worth it or not. Everything in life is a trade-off, after all. It is only in a culture where litigation thrives that miracle drugs like HRT, or anti-inflammatory agents (e.g., Vioxx, Celebrex, Ibuprofen etc.) are damned because they have side effects. EVERY SINGLE DRUG HAS SIDE EFFECTS. Litigation is only possible if the indiviudal abrogates his/her own personal responsibility in determining what the risk versus benefit is for each medication they are prescribed ...