Abstract: : Purpose: To study the distribution of SPARC (secreted protein acidic and rich in cysteine) in the murine lens. SPARC has been shown to be an essential factor in the development and maintenance of lens transparency in mice because all SPARC-null mice begin to form cataract within 1 month after birth. It is therefore important to identify the localization and cellular expression of SPARC in the murine lens. Method: Immunohistochemistry and immunoblot analyses were conducted on murine lens capsule and on lens cells from E14 to 2 yr; steady-state levels of SPARC mRNA in lens cells were determined by RT-PCR. Results: Lens epithelium produced abundant SPARC as early as E14; the protein remained at high levels up to 2 yr of age. By immunohistochemistry and RT-PCR, the lens fiber cells at the equator were shown to contain SPARC, but not the secondary fibers located inside the bow region. The lens capsule did not contain SPARC. SPARC protein was also identified in the vitreous. Proteolytic ...

Osteonectin (OSN) is a glycoprotein which is implicated in development, bone formation and mineralisation, tumorigenesis, angiogenesis, and wound healing. Regulation of its expression by hormones may be one of the mechanisms by which the endocrine system affects bone metabolism. As a first step to understanding OSN function in fish, the gene expression of the recently cloned cDNA for sea bream, Sparus auratus, osteonectin (sbOSN) was characterised during embryonic and larval development. sbOSN mRNA was first detected by semi-quantitative reverse transcription-polymerase chain reaction in embryos at early gastrula and its expression increased continuously until hatch, after which it decreased until 15 days post-hatch (dph), increased transiently until 24 dph and decreased thereafter. In situ hybridisation showed it had a differential tissue distribution which was age dependent. In general, sbOSN mRNA was identified in cartilaginous and calcified structures of both dermal and endochondral origin ...

From NCBI Gene:. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]. From UniProt: ...

Results A single bout of exercise increased the expression and secretion of SPARC in skeletal muscle in both mice and humans. In addition, in an azoxymethane-induced colon cancer mouse model, regular low-intensity exercise significantly reduced the formation of aberrant crypt foci in wild-type mice but not in SPARC-null mice. Furthermore, regular exercise enhanced apoptosis in colon mucosal cells and increased the cleaved forms of caspase-3 and caspase-8 in wild-type mice but not in SPARC-null mice. Culture experiments showed that SPARC secretion from myocytes was induced by cyclic stretch and inhibited proliferation with apoptotic effect of colon cancer cells.. ...

Purpose and History During prostate advancement mesenchymal-epithelial connections regulate body organ development and differentiation. in situ hybridisation display screen and researched Decorin (Dcn) Semaphorin6D (Sema6D) SPARC/Osteonectin (SPARC) Sprouty1 (Spry-1) and Tsukushi (Tsku). Appearance in rat SYN-115 tissue was examined using wholemount in situ hybridisation (postnatal time (P) 0.5) and immunohistochemistry (embryonic time (E) E17.5 E19.5; P0.5; P6; 28 & adult). Four applicants (Decorin SPARC Spry-1 Tsukushi) had been immunolocalised in individual foetal prostate (weeks 14 16 19 and appearance of Decorin was examined on a individual prostate tumor tissues microarray. In embryonic and perinatal rats Decorin Semaphorin6D SPARC Spry-1 and Tsukushi had been expressed with differing distribution patterns through the entire mesenchyme at E17.5 E19.5 P0.5 and P6.5. In P28 and adult prostates there is either a reduction in the appearance (Semaphorin6D) or a change to epithelial appearance ...

The adverse health effects of exposure to asbestos are widely known and have been well documented. When a person is diagnosed with asbestosis, a chronic lung disease caused by inhaling asbestos fibers, few treatment options exist, none of which halt or reverse the progression of the disease. The rapidly growing field of gene therapy offers new avenues for potential treatments worthy of investigation. The detrimental effects of asbestos exposure are due to the physiological response of the lungs to asbestos fibers in the form of fibrosis, a result of excess extracellular collagen deposition. A protein called SPARC (Secreted Protein Acidic and Rich in Cysteine) has been identified in previous studies as being a matricellular protein involved in the fibrotic response following asbestos exposure. Using the principle of RNA interference, we aimed to knock down the expression of SPARC in our studies, hypothesizing that a reduction in SPARC expression would yield a reduction in fibrosis. In our in vitro

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene. This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The proteins function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition. GRCh38: Ensembl release 89: ENSG00000152377 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000056222 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. Genomics. 48 (3): 377-80. doi:10.1006/geno.1997.5199. PMID 9545645. Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1. Périn JP, Alliel PM, Jollès P, Bonnet F (1994). ...

osteonectin. // Tabers Cyclopedic Medical Dictionary;2005, p1545 A definition of the medical term osteonectin is presented. Osteonectin refers to a glycoprotein present in the noncollagenous portion of the matrix bone. The definition is from the Tabers Cyclopedic Medical Dictionary, published by F.A. Davis Co. The pronunciation of the term is also provided. ...

Krock E, Millecamps M, Anderson KM, Srivastava A, Reihsen TE, Hari P, Sun YR, Jang SH, Wilcox GL, Belani KG, Beebe DS, Ouellet J, Pinto MR, Kehl LJ, Haglund L, Stone LS. Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model. EBioMedicine. 2019 Apr 29. pii: S2352-3964(19)30271-3. [link ...

زمینه و هدف: در کلسیفیه شدن دیواره رگ ها یک از عوامل مهم در پاتوژنز آترواسکلروز است و پروتئین های ماتریکس استخوان و فاکتورهای تنظیمی از جمله استئونکتین نقش اساسی در تشکیل آتروم و پیشرفت آترواسکلروز به عهده دارند. مطالعات نشان داده اند که مصرف آنتی اکسیدان ها سبب کاهش کلسیفیه شدن عروق و کاهش بروز بیماری های قلبی عروقی می گردند. در این مطالعه تاثیر اسید گالیک بر بیان ژن استئونکتین مورد بررسی قرار گرفت. روش بررسی: در این مطالعه تجربی، میزان مهارکنندگی 50 (IC50) اسید گالیک بر سلول های عضله صاف دیواره رگ ها در سلول های کشت شده تعیین گردید؛ سپس این سلول ها با غلظت ...

wearyellowforseth (1) 2joy-21 (1) A01 (2) A02 (2) A19 (1) A34 (3) A40 (1) acryl (13) acrylverf (100) Alcohol inks (19) Apipila-L18 (5) B.03 Mind Blown (4) B01 (1) B08 (1) B11 (1) B44 (1) Big SdP-B (17) Big SdP-B2 (2) Big SdP-G (7) Big SdP-K (13) Big SdP-O (7) Big SdP-T (2) Big SdP-V (4) birthday collab (1) BM 03 (1) BM-01 (1) BM-02 (4) BM-04 (5) BM-08 (1) BM-09 (1) BM-13 (4) BM-14 (2) BM-167 (1) BM-18 (1) BM-201 (2) BM-205 (2) BM-208 (2) BM-212 (1) BM-213 (1) BM-214 (2) BM-215 (1) BM-221 (2) BM-223 (1) BM-224 (3) BM-225 (3) BM-301 (1) BM-304 (1) BM-305 (5) BM-307 (2) BM-308 (1) BM-309 (3) BM-311 (1) BM-312 (1) BM-314 (2) BM-315 (1) BM-317 (1) BM-318 (3) BM-321 (3) BM-322 (1) BM-323 (1) BM-324 (2) BM-408 (1) BM-409 (1) BM-412 (1) BM-413 (1) BM-414 (1) BM-415 (1) BM-416 (1) BM-422 (1) BM-603 (1) BM-604 (1) BM-607 (1) BM-613 (1) BM-619 (1) BM-708 (1) BM-710 (1) bm-717 (1) BM-719 (1) BM-720 (1) BM-H01 (1) BM-H03 (3) BM-H04 (1) BM-H05 (1) BM-H06 (2) BM-H07 (1) BM-H08 (1) BM-H09 (1) BM-H12 (1) BM-H13 ...

wearyellowforseth (1) 2joy-21 (1) A01 (2) A02 (2) A19 (1) A34 (3) A40 (1) acryl (13) acrylverf (100) Alcohol inks (19) Apipila-L18 (5) B.03 Mind Blown (4) B01 (1) B08 (1) B11 (1) B44 (1) Big SdP-B (17) Big SdP-B2 (2) Big SdP-G (7) Big SdP-K (13) Big SdP-O (7) Big SdP-T (2) Big SdP-V (4) birthday collab (1) BM 03 (1) BM-01 (1) BM-02 (4) BM-04 (5) BM-08 (1) BM-09 (1) BM-13 (4) BM-14 (2) BM-167 (1) BM-18 (1) BM-201 (2) BM-205 (2) BM-208 (2) BM-212 (1) BM-213 (1) BM-214 (2) BM-215 (1) BM-221 (2) BM-223 (1) BM-224 (3) BM-225 (3) BM-301 (1) BM-304 (1) BM-305 (5) BM-307 (2) BM-308 (1) BM-309 (3) BM-311 (1) BM-312 (1) BM-314 (2) BM-315 (1) BM-317 (1) BM-318 (3) BM-321 (3) BM-322 (1) BM-323 (1) BM-324 (2) BM-408 (1) BM-409 (1) BM-412 (1) BM-413 (1) BM-414 (1) BM-415 (1) BM-416 (1) BM-422 (1) BM-603 (1) BM-604 (1) BM-607 (1) BM-613 (1) BM-619 (1) BM-708 (1) BM-710 (1) bm-717 (1) BM-719 (1) BM-720 (1) BM-H01 (1) BM-H03 (3) BM-H04 (1) BM-H05 (1) BM-H06 (2) BM-H07 (1) BM-H08 (1) BM-H09 (1) BM-H12 (1) BM-H13 ...

Different tumor microenvironments (TMEs) induce stromal cell plasticity that affects tumorigenesis. The impact of TME-dependent heterogeneity of tumor endothelial cells (TECs) on tumorigenesis is unclear. Here, we isolated pure TECs from human colorectal carcinomas (CRCs) that exhibited TMEs with either improved (Th1-TME CRCs) or worse clinical prognosis (control-TME CRCs). Transcriptome analyses identified markedly different gene clusters that reflected the tumorigenic and angiogenic activities of the respective TMEs. The gene encoding the matricellular protein SPARCL1 was most strongly upregulated in Th1-TME TECs. It was also highly expressed in ECs in healthy colon tissues and Th1-TME CRCs but low in control-TME CRCs. In vitro, SPARCL1 expression was induced in confluent, quiescent ECs and functionally contributed to EC quiescence by inhibiting proliferation, migration, and sprouting, whereas siRNA-mediated knockdown increased sprouting. In human CRC tissues and mouse models, vessels with ...

diff --git a/arch/sparc/kernel/of_device.c b/arch/sparc/kernel/of_device.c index c590148..4ef1607 100644 --- a/arch/sparc/kernel/of_device.c +++ b/arch/sparc/kernel/of_device.c @@ -344,6 +344,27 @@ static int __init build_one_resource(struct device_node *parent, return 1; } +static int __init use_1to1_mapping(struct device_node *pp) +{ + /* If we have a ranges property in the parent, use it. */ + if (of_find_property(pp, ranges, NULL) != NULL) + return 0; + + /* Some SBUS devices use intermediate nodes to express + * hierarchy within the device itself. These arent + * real bus nodes, and dont have a ranges property. + * But, we should still pass the translation work up + * to the SBUS itself. + */ + if (!strcmp(pp-,name, dma) ,, + !strcmp(pp-,name, espdma) ,, + !strcmp(pp-,name, ledma) ,, + !strcmp(pp-,name, lebuffer)) + return 0; + + return 1; +} + static int of_resource_verbose; static void __init build_device_resources(struct of_device *op, @@ -389,10 +410,7 @@ static void ...

This book describes the assembler that runs on the SPARC architecture and translates source files that are in assembly language format into object files in linking format. The text in this book is current to Solaris 7 software.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC): Comprehensive Functional Mapping of Neuroanatomy and Neurobiology of Organs (OT2) RFA-RM-15-018. Roadmap

In reply to Lars Wendler (Polynomial-C) from comment #1) , Arches please test and mark stable the following versions: , , =media-libs/libpng-1.2.54: , ~alpha amd64 ~arm arm64 ~hppa ~ia64 m68k ~mips ~ppc64 s390 sh ~sparc x86 , ~sparc-fbsd ~x86-fbsd ~amd64-linux ~x86-linux Most of these have no stable keywords on this SLOT. , =media-libs/libpng-1.5.24: , ~alpha amd64 ~arm ~arm64 ~hppa ~ia64 ~m68k ~mips ~ppc ~ppc64 ~s390 ~sh , ~sparc x86 ~amd64-fbsd ~sparc-fbsd ~x86-fbsd ~x64-freebsd ~x86-freebsd , ~x86-interix ~amd64-linux ~arm-linux ~x86-linux ~ppc-macos ~x64-macos , ~x86-macos ~m68k-mint ~sparc-solaris ~sparc64-solaris ~x64-solaris , ~x86-solaris ~x86-winnt Most of these have no stable keywords on this SLOT. , =media-libs/libpng-1.6.19: , alpha amd64 arm ~arm64 hppa ia64 ~m68k ~mips ppc ppc64 ~s390 ~sh sparc x86 , ~ppc-aix ~amd64-fbsd ~sparc-fbsd ~x86-fbsd ~x64-freebsd ~x86-freebsd , ~x86-interix ~amd64-linux ~arm-linux ~x86-linux ~ppc-macos ~x64-macos , ~x86-macos ~m68k-mint ~sparc-solaris ...

A SPARC Associate, in the constituency, works as a catalyst to mobilize resources from poorly performing government schemes by working through the office of the MP and activating key levers within the government system to make it more effective. Apart from the government schemes, the Associate also identifies and implements projects that can benefit the constituents by sourcing funds from either CSR or government programs.. OUR REACH. ...

AnalysisWhen Oracle announced the eight-core Sparc T4 processor and the four systems that make use of the new chip to run Solaris workloads two weeks ago, the one thing that was missing on announcement day was pricing for the systems. Having lived through Oracle OpenWorld, El Reg figures now is a good time to circle back and take a look at packaging and pricing for the Sparc T4 machines and how they stack up to prior generations of Sparc T-class iron ...

We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly ...

上海凱倫BM-2013-KMB報站系統是一個由上海凱倫生產的自動巴士到站提示廣播系統，現時系統應用在全部九巴及龍運巴士現役巴士。 隨著GPS全球定位功能更加準確，九巴及龍運巴士決定在新購置的巴士安裝自動報站系統，以減輕車長工作量。…

Several lines of evidence point out that the trabecular meshwork ECM is indeed the source of aqueous humor outflow resistance, and that MMP-9 is a potent modulator of the trabecular meshwork architecture. Ultrastructural examinations of the trabecular meshwork of POAG patients reveal a shift in ECM composition as well as decreased MMP-9 activity, and a reciprocal interplay between both.32-34 Furthermore, overexpression of the matricellular protein SPARC in human anterior segment explant cultures results in elevated IOP and qualitative changes in the ECM of the trabecular meshwork (i.e., elevated collagen I, IV, and VI; laminin; and fibronectin levels) that could be linked to a shift in MMP/TIMP balance and a selective decrease in MMP-9 activity.33,35 This evidence for an important role for MMP-9 in IOP homeostasis has been corroborated by in vitro experiments using perfused human anterior segment organ cultures, to which addition of recombinant MMP-9 results in a reversible increase in outflow ...

Protein BM-1 (bahasa Inggris: procollagen C-peptidase, bone morphogenetic protein 1, mammalian tolloid, mTLD, procollagen C-proteinase, procollagen C-terminal proteinase; carboxyprocollagen peptidase; procollagen C-terminal peptidase; procollagen C-proteinase; procollagen C-terminal proteinase; procollagen carboxypeptidase; procollagen carboxy-terminal proteinase; procollagen peptidase, BMP-1, EC 3.4.24.19) merupakan enzim metaloprotease yang mengiris terminus-C pada posisi Ala-Asp pada prokolagen tipe I dan II, dan pada posisi arg-Asp pada prokolagen tipe III,[1] dalam proses aktivasi prekursor protein yang berperan dalam pembentukan jaringan matriks ekstraselular, termasuk aktivasi protelitik terhadap zimogen dari oksidase lisil.[2] Marimastat merupakan senyawa penghambat aktivitas BMP-1.[3] Aktivitas BMP-1 akan meningkat oleh kalsium, fibronektin,[2] sFRP,[4] dan sejenis glikoprotein dengan kofaktor berupa Zn,[5] Protein sFR merupakan target terapi fibrosis jantung.[4] ...

During progression of melanoma, malignant melanocytes can be reprogrammed into mesenchymal-like cells through a process similar to epithelial-mesenchymal transition (EMT), which is associated with downregulation of the junctional protein E-cadherin and acquisition of a migratory phenotype. Recent evidence supports a role for SLUG, a transcriptional repressor of E-cadherin, as a melanocyte lineage transcription factor that predisposes to melanoma metastasis. However, the signals responsible for SLUG expression in melanoma are unclear and its role in the invasive phenotype is not fully elucidated. Here, we report that SLUG expression and activation is driven by SPARC (also known as osteonectin), a secreted extracellular matrix-associated factor that promotes EMT-like changes. Ectopic expression or knockdown of SPARC resulted in increased or reduced expression of SLUG, respectively. SLUG increase occurred concomitantly with SPARC-mediated downregulation of E-cadherin and P-cadherin, and induction ...

Objective: To examine the hypothesis that degenerative aortic stenosis (AS) is associated with the development of blood vessels and the expression of the secreted protein, acidic and rich in cysteine/osteonectin (SPARC), a matricellular protein that is involved in ossification, the modulation of angiogenesis and the production of metalloproteinases.. Methods: 30 surgically excised AS valves and 20 normal aortic valves were studied.. Results: Blood vessels were detected in the aortic valves from patients with degenerative AS, whereas normal valves were avascular structures. Blood vessels in AS valves expressed endothelial nitric oxide synthase, CD34 and von Willebrand factor (vWF). Blood vessels were located in three distinct regions: near calcified nodules, under the leaflet border and in rich cellular areas forming cell islands. Blood vessels were predominantly present in early and intermediate grades of calcification. Cell islands were densely populated by CD45-positive cells where endothelial ...

TY - JOUR. T1 - Cardiac extracellular matrix remodeling: Fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC). AU - McCurdy, Sarah. AU - Baicu, Catalin F.. AU - Heymans, Stephane. AU - Bradshaw, Amy D.. PY - 2010/3. Y1 - 2010/3. KW - BM-40. KW - Osteonectin. KW - SPARC. KW - Extracellular matrix. KW - Remodeling. KW - Review. U2 - 10.1016/j.yjmcc.2009.06.018. DO - 10.1016/j.yjmcc.2009.06.018. M3 - Article. C2 - 19577572. VL - 48. SP - 544. EP - 549. JO - Journal of Molecular and Cellular Cardiology. JF - Journal of Molecular and Cellular Cardiology. SN - 0022-2828. IS - 3. ER - ...

Young (3 mo old) and old (18-24 mo old) wild-type (WT) and SPARC-null mice were studied. LV collagen content was measured histologically by collagen volume fraction, collagen composition was measured by hydroxyproline assay as soluble collagen (1 M NaCl extractable) versus insoluble collagen (mature cross-linked), and collagen morphological structure was examined by scanning electron microscopy ...

Historically, VEGFR-1 was assigned a role as a nonsignaling decoy receptor because of the low activity and embryonic dispensability of its tyrosine kinase function. More recently, its role has become more interesting because VEGFR-1 signaling has been reported both to promote (6, 7) and suppress (8) VEGF-A-driven angiogenesis. We report not only that PlGF-1 inhibits inflammatory CNV, extending the scope of VEGFR-1 function, but also what we believe is the unprecedented observation that VEGF-A itself can suppress angiogenesis. Multiple lines of evidence emerging from genetic ablation, antibody neutralization, and receptor-selective ligand activation all strongly support the thesis that the antiangiogenic action of VEGF-A is mediated by VEGFR-1. Previously, VEGF-A has been reported to reduce VEGF-E-induced VEGFR-2 tyrosine kinase phosphorylation in capillary endothelial cells in vitro, raising the provocative hypothesis that VEGF-A could limit its own angiogenic activity through VEGFR-1 (29). We ...

SMOC-1 and SMOC-2, two extracellular matrix proteins, were cloned as full length proteins but also as fragments that contained only single domains or the combination of three or four domains. The proteins were recombinantly expressed in eukaryotic cell lines, purified by affinity chromatography and used to immunize animals or to perform functional assays. An antiserum against SMOC-2 could be affinity purified with the help of the new recombinant proteins, which allowed the analysis of expression and tissue distribution of SMOC-2. In adult mouse, heart, spleen, thymus, ovary and, particularly, lung, kidney, cartilage and skin were found to be the organs where SMOC-2 is mainly expressed. During embryonic development SMOC-2 was first detected at basement membranes at embryonic day 7.5, but the expression was not limited to these structures. Starting at day 10.5 the distribution became broader and SMOC-2 was continuously present until adulthood. In zebrafish, the SMOCs were shown to be important ...

NetBSD/sparc is based on work done at Lawrence Berkeley Laboratory by the Computer Systems Engineering group under DARPA contract BG 91-66, which later appeared in the 4.4BSD-Lite distribution from the University of California, Berkeley. It was imported into the NetBSD source tree on October 2, 1993. Special thanks are extended to the LBL Computer Systems Engineering group for their work. Without which, this port would not exist. For frequently asked questions and links to Sun hardware information, see the NetBSD/sparc FAQ. For newer UltraSPARC-based machines, see NetBSD/sparc64. ...

Eldis editor Alan Stanley was invited to Abuja recently to attend the State Partnership for Accountability, Responsiveness and Capability (SPARC) end-of-programme learning event. Based on what he heard he highlights five key lessons from the programme on effective governance reform. Back in 2013, after some brief meetings and correspondence via email, Eldis began a content partnership with the State Partnership for Accountability, Responsiveness and Capability (SPARC).

Sparc in Mumbai -Contact details and more information from Sparc in Mumbai. Search through over 7564, NGOs database by State, City or Pincode.

Affiliation (Current)：金沢大学,附属病院,助教, Research Field：Radiation science,Basic Section 52040:Radiological sciences-related, Keywords：神経芽腫,内照射療法,内用療法,放射線管理,matricellular protein,annexin V,α線,tenascin C,消化器癌,虚血性心疾患, # of Research Projects：7, # of Research Products：41, Ongoing Project：Development of new therapeutoc strategy for high-risk chemotherapy-refractory neuroblastoma

KEYWORDS=~alpha ~amd64 ~arm ~hppa ~ia64 ~mips ~ppc ~ppc64 ~s390 ~sh ~sparc ~x86 ~amd64-fbsd ~x86-fbsd ~x86-freebsd ~x86-interix ~amd64-linux ~x86-linux ~ppc-macos ~x64-macos ~x86-macos ~sparc-solaris ~sparc64-solaris ~x64-solaris ~x86-solaris ...

If I understand your description right, it sounds as if the POSIX model is incompatible with both of the old ways of switching between two euids: either using setreuid() to swap uid,-,euid, or using setuid() to switch from uid=0 to some other uid and being able to switch back later because the saved uid remembers that you are really root. (Do I misunderstand?) I can understand wanting to be POSIX compatible, but is it necessary to break binary compatibility? Especially on sparc or other legacy systems? (Could there be a kernel option to allow the old behavior?) As for the setreuid() routine, if its not going to work as expected, Id rather see it removed entirely from libc. That way, when porting code, you find out a link time rather than at run time. Keith ...

libreoffice-officebean (1:3.5.4+dfsg2-0+deb7u10 [amd64, armel, armhf, i386], 1:3.5.4+dfsg2-0+deb7u6 [kfreebsd-amd64, kfreebsd-i386, s390x], 1:3.5.4+dfsg2-0+deb7u5 [powerpc, s390], 1:3.5.4+dfsg2-0+deb7u4 [mipsel, sparc], 1:3.5.4+dfsg2-0+deb7u3 [mips], 1:3.5.4+dfsg2-0+deb7u2 [ia64]) [security ...

Marian Blanca Ramírez from the CSIC in Spain has been studying the effects of LRRK2, a protein associated with Parkinsons disease, on cell motility. A Travelling Fellowship from Journal of Cell Science allowed her to spend time in Prof Maddy Parsons lab at Kings College London, learning new cell migration assays and analysing fibroblasts cultured from individuals with Parkinsons. Read more on her story here. Where could your research take you? The deadline to apply for the current round of Travelling Fellowships is 23rd Feburary 2018. Apply now!. ...

TY - JOUR. T1 - Matricellular protein CCN3 mitigates abdominal aortic aneurysm. AU - Zhang, Chao. AU - Van Der Voort, Dustin. AU - Shi, Hong. AU - Zhang, Rongli. AU - Qing, Yulan. AU - Hiraoka, Shuichi. AU - Takemoto, Minoru. AU - Yokote, Koutaro. AU - Moxon, Joseph V.. AU - Norman, Paul. AU - Rittié, Laure. AU - Kuivaniemi, Helena. AU - Atkins, G. Brandon. AU - Gerson, Stanton L.. AU - Shi, Guo Ping. AU - Golledge, Jonathan. AU - Dong, Nianguo. AU - Perbal, Bernard. AU - Prosdocimo, Domenick A.. AU - Lin, Zhiyong. N1 - Funding Information: This work was supported by NIH grants HL117759 and AA021390 (to Z. Lin). This work was also supported in part by the National Nature Science Foundation of China (grant number 31330029).. PY - 2016/4/1. Y1 - 2016/4/1. N2 - Abdominal aortic aneurysm (AAA) is a major cause of morbidity and mortality; however, the mechanisms that are involved in disease initiation and progression are incompletely understood. Extracellular matrix proteins play an integral role in ...

Chronic degenerative disease of the mares endometrium is characterised by changes in the uterine glands, including cystic dilation, hyperplasia and periglandular fibrosis. Endometrial biopsies were taken from 23 mares with different grades of endometrial degeneration. Solid structures were identified within the lumina of the uterine glands and shown to be calcified by histochemical staining. Most of them were not homogenous but composed of a mixture of mineral and organic substances. Further examinations of these mineralised structures by immunohistochemical methods revealed the presence of the non-collagenous matrix proteins osteopontin, osteonectin and bone sialoprotein, which are known to be involved in calcification processes such as urolithiosis. Osteopontin and bone sialoprotein were identified within the calculi, frequently arranged in concentric layers. Osteonectin was the only matrix protein that was also present in the glandular epithelium. Osteocalcin was not found in either the ...

Exercise and physical activity levels influence myokine release from skeletal muscle and contribute to circulating concentrations. Indeed, many myokines, including interleukin (IL)-6, IL-15, secreted protein acidic rich in cysteine (SPARC), and fibroblast growth factor (FGF) 21 are higher in the circulation after an exercise bout. Since these peptides modulate muscle metabolism and can also be targeted toward other tissues to induce adaptations to energy demand, they are of great interest regarding metabolic diseases. Therefore, we set out to compare, in six women with obesity (BMI ≥30 kg/m2) and five healthy women (BMI 22-29.9 kg/m2), the effect of an acute bout of moderate-intensity, continuous cycling exercise (60 min, 60% VO2peak) on the release of myokines (IL-6, IL-8, IL-10, IL-13, IL-15, SPARC, and FGF21) in plasma for a 24-h time course. We found that plasma IL-8 and SPARC levels were reduced in the group of women with obesity, whereas plasma IL-13 concentrations were elevated in comparison to

Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Periostin has since been demonstrated to be important in heart valve development and myocardial infarction because it promotes collagen fibrogenesis, inhibits differentiation of progenitor cells into cardiomyocytes and is essential in maintaining the biomechanical properties of the adult myocardium. This antibody detects a 93-kDa periostin doublet, which corresponds to the two largest forms of the alternatively spliced region of periostin with a distinctive ...

4360 Secreted acidic protein rich in cysteine (SPARC) has been suggested as a potential glioma invasion promoting gene. SPARC is highly expressed in human gliomas, promotes glioma invasion, and delays tumor growth in vitro and in vivo. cDNA array reports were performed to determine whether SPARC, which interacts at the cell surface, has an impact on intracellular signaling and downstream gene expression changes that might account for some of its effects on invasion and growth. Additional in vitro studies demonstrated that SPARC delays growth, increases attachment, and modulates migration of tumor cells in extracellular matrix-specific and concentration-dependent manners. It has been reported that SPARC functionally contributes to brain tumor invasion and delays tumor growth in vivo, and that the effects of SPARC are related to the level of SPARC secreted into the extracellular matrix. Thus far, the signaling aspects of glioma migration and invasion are not fully understood. As such, we made an ...

Data Availability StatementThe datasets helping the conclusions of this article are included within the article. scanning electron microscopy (SEM). Moreover, scaffold properties, such as pore size and morphology of the cells, onto the scaffolds were evaluated using SEM. Furthermore, biocompatibility of these scaffolds was confirmed by 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results The matrix mineralization was proved by alizarin reddish staining, and the osteogenic media-treated cultures positively expressed osteocalcin and osteopontin markers. Moreover, qRT-PCR results confirmed the positive gene expression of osteopontin and osteonectin in the differentiated osteoblast-like cells. The results of behavior assessment of the cultured cells on electrospinning and freeze-dried scaffolds demonstrated the fact that behavior from the cultured cells in the freeze-dried PLGA/HA scaffolds was considerably much better than the electrospinning PLGA/HA scaffolds. Bottom ...

Collagens are substantial constituents of the extracellular matrix (ECM) of every organ system, and virtually every cell in a tissue has the opportunity to interact with fibrillar or basement membrane collagens in the context of tissue development, remodeling, or homeostasis. Tissue architecture is governed by the structure imparted by the ECM; maintenance of this architecture is a barrier to malignant transformation. However, documentation that dysfunctional or inappropriate ECM contributes directly to tumor development is uncommon.. Collagen secretion, fibrillogenesis, and deposition are the result of a precise series of biochemical events that are facilitated by extracellular adaptor proteins, including proteogylcans (e.g., fibromodulin, lumican, and decorin) and matricellular proteins such as secreted protein acidic and rich in cysteine (SPARC; ref. 1). Of these extracellular adaptor proteins, SPARC has received considerable attention in the context of tumor development and progression. ...

Background In India, solar energy constitutes just 1% of the energy mix, but the Government aims to increase this to around 10% by 2020 by adding 100

libreoffice-ogltrans (1:3.5.4+dfsg2-0+deb7u9 [amd64, armhf, i386], 1:3.5.4+dfsg2-0+deb7u6 [kfreebsd-amd64, kfreebsd-i386, s390x], 1:3.5.4+dfsg2-0+deb7u5 [powerpc, s390], 1:3.5.4+dfsg2-0+deb7u4 [sparc], 1:3.5.4+dfsg2-0+deb7u2 [ia64]) [security ...

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TY - CHAP. T1 - Osteonectin promoter-mediated suicide gene therapy of prostate cancer. AU - Hsiao, Wan Chi. AU - Sung, Shian Ying. AU - Chung, Leland W.K.. AU - Hsieh, Chia Ling. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Suicide gene therapy using the herpes simplex virus thymidine kinase (HSV-tk) gene, combined with the prodrug ganciclovir (GCV) medication, is a promising approach for the treatment of malignant tumors, including prostate cancer. The success of this therapeutic strategy requires tissue- or tumor-specific gene expression and efficient gene delivery. In this chapter, we describe the experimental protocols of key methodologies, including promoter construction, reporter assay, adenoviral vector construction and preparation, HSV-tk enzymatic assay and cytotoxicity assay to evaluate the specificity and efficacy of osteonectin promoter-mediated HSV-tk/GCV suicide gene therapy of prostate cancer.. AB - Suicide gene therapy using the herpes simplex virus thymidine kinase (HSV-tk) gene, combined ...

Root cementum represents one of the crucial prerequisites for an intact fixation in the tooths osseous socket, the alveole. Healthy cementum and its self-repair mechanisms are furthermore vital to a sound parodontium and thus for the entire dental health. Central to the thesis at hand was the collection of human cementoblasts from extracted teeth. These had to be cultivated, immortalized and characterized. The ensuing examination covered an analysis of proteins that are presumed typical for cement and bone. Such proteins include collagen type I and III, osteocalcin, osteopontin, bone sialoprotein and osteonectin. Other findings include both transcription factors RUNX2 and SOX9, both of which are not extensively researched in context with cementum yet. This holds true in particular for SOX9. Even though typical for the chondrogenic cell line, this transcription factor and its interrelation with cementum is not covered in relevant literature. In contrast to this, the literary research has ...

Material Transfer Agreements (MTAs): MTAs are agreements that govern the transfer of various biological and research materials. An MTA must be signed by an authorized signatory of the College before any material is transferred. If you are interested in receiving materials from another institution, a nonprofit, or a for-profit organization and have received a draft MTA or are interested in initiating the process, please contact SPARC. SPARC will review and work with appropriate constituencies to facilitate material transfers. ...

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results/packages not available yet due to machine rebuild ] pkgsrc bulk build results SunOS 5.9/sparc Summary: Build started: Mon Sep 05 13:52:20 2005 UTC Build ended: Sat Sep 10 23:13:49 2005 UTC Successfully packaged: 2410 Packages really broken: 1187 Pkgs broken due to them: 1545 Total broken: 2732 Not packaged: 323 Total: 3055 Packages not listed here resulted in a binary package. The build report, including logs of failed/not-packaged is available from: ftp://ftp0.mh.bbc.co.uk/pub/pkgsrc/pkgstat/20050911.0013/broken.html Top Ten Offenders Package Breaks Maintainer -------------------------------------------------------------- lang/python23 321 [email protected] security/heimdal 311 [email protected] textproc/aspell 197 [email protected] devel/pcre 179 [email protected] x11/qt3-tools 179 [email protected] graphics/openexr 148 [email protected] net/mDNSResponder 147 [email protected] devel/libltdl 141 [email protected] graphics/netpbm 124 [email protected] www/php4 76 [email protected] Broken packages ...

1813178DNAHomo sapiens 1gttgcctgtc tctaaacccc tccacattcc cgcggtcctt cagactgccc ggagagcgcg 60ctctgcctgc cgcctgcctg cctgccactg agggttccca gcaccatgag ggcctggatc 120ttctttctcc tttgcctggc cgggagggcc ttggcagccc ctcagcaaga agccctgcct 180gatgagacag aggtggtgga agaaactgtg gcagaggtga ctgaggtatc tgtgggagct 240aatcctgtcc aggtggaagt aggagaattt gatgatggtg cagaggaaac cgaagaggag 300gtggtggcgg aaaatccctg ccagaaccac cactgcaaac acggcaaggt gtgcgagctg 360gatgagaaca acacccccat gtgcgtgtgc caggacccca ccagctgccc agcccccatt 420ggcgagtttg agaaggtgtg cagcaatgac aacaagacct tcgactcttc ctgccacttc 480tttgccacaa agtgcaccct ggagggcacc aagaagggcc acaagctcca cctggactac 540atcgggcctt gcaaatacat ccccccttgc ctggactctg agctgaccga attccccctg 600cgcatgcggg actggctcaa gaacgtcctg gtcaccctgt atgagaggga tgaggacaac 660aaccttctga ctgagaagca gaagctgcgg gtgaagaaga tccatgagaa tgagaagcgc 720ctggaggcag gagaccaccc cgtggagctg ctggcccggg acttcgagaa gaactataac 780atgtacatct tccctgtaca ctggcagttc ggccagctgg accagcaccc cattgacggg 840tacctctccc acaccgagct ...

On Tue, 2016-01-12 at 10:36 -0200, Adhemerval Zanella wrote: , , On 12-01-2016 10:25, Torvald Riegel wrote: , , On Mon, 2016-01-11 at 18:52 -0200, Adhemerval Zanella wrote: , ,, Hi all, , ,, , ,, At stated in a previous message we are now in soft/slushy freeze mode. , ,, Please do not commit new features other than the ones already reviewed. , ,, If your new feature still needs review and was not listed in the releases , ,, wiki as a blocker feature [2] it is unfortunately too late. Please defer , ,, to glibc 2.23 when it opens. , , , , The barrier patch has been reviewed by Paul Murphy and tested by him on , , Power. Paul said he might prefer if someone else reviewed it too, , , though. Can this be considered reviewed then? , , I will also check it on aarch64/arm today and I also would like to see it , on 2.23. Thanks! , The only bit I am not sure is the sparc stated by you it might , broke on newer implementation. Do you think we can get sparc parts done , and tested by the end of the week? ...

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Oracle and Fujitsu have strengthened their multi-decade partner-ship with the extension of their SPARC development relationship, an expansive, new distribution agreement and a commitment to further joint engineering, marketing and sales promotion efforts. On April 10th 2013 Fujitsu and Oracle announced the worldwide availability of Fujitsu M10 servers, based on the 16-core SPARC64 X processor ...

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ESAs SPectra bARrax Campaign (SPARC) activity was part of the preparatory study for a proposed ESA Earth Explorer mission called SPECTRA. The objective was to collect a CHRIS/PROBA reference dataset for SPECTRA-related studies.. ...

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