Sparc (Osteonectin) is a multifunctional matricellular glycoprotein expressed by many differentiated cells. Members of this family mediate cell-matrix interactions rather than acting as structural components of the extracellular matrix and therefore can influence many remodelling events, including haematopoiesis. We have investigated the role of sparc in embryonic haematopoiesis, using a morpholino antisense oligonucleotidebased knockdown approach. Knockdown of sparc function resulted in specific erythroid progenitor cell differentiation defects that were highlighted by changes in gene expression and morphology, which could be rescued by injection of sparc mRNA. Furthermore, a comparison of blood phenotypes of sparc and fgfs knockdowns with similar defects and the sparc rescue of fgf21 blood phenotype places sparc downstream of fgf21 in the genetic network regulating haematopoiesis in zebrafish. These results establish a role for an extracellular matrix protein (Sparc) as an important regulator ...
Recombinant Mouse SPARC protein (His tag) is a HEK 293 Full length protein 1 to 302 aa range, | 96% purity, | 1.000 Eu/µg endotoxin level and validated in SDS-PAGE.
Secreted protein and rich in cysteine, SPARC (also known as osteonectin; or basement-membrane-40, BM-40), is a member of a family of matricellular proteins, whose function is to modulate cell-matrix interactions and cell function without participating in the structural scaffold of the extracellular matrix. Overexpression of SPARC has been documented in several types of solid tumors, such as breast[7], prostate[8], melanoma[9] and glioblastomas[10]. In contrast, lower levels of SPARC expression have been found in other types of cancers, such as ovarian[11], colorectal[12], pancreatic[13, 14] and acute myelogenous leukemia[15]. These observations suggest that tumorigenic effect of SPARC is cell type specific and may be dependent of the tumor cell surrounding environment.. The knowledge about SPARC functions in gastric cancer cells is still sparse. Some immunohistochemical studies[16-20, 22] collectively reported an up-regulation of SPARC in gastric cancer compared with nonneoplastic mucosa. Wewer ...
Dive into the research topics of Structural and functional characterization of the extracellular calcium-binding protein BM-40/secreted protein, acidic, rich in cysteine/osteonectin from the nematode Caenorhabditis elegans. Together they form a unique fingerprint. ...
Background: Oxidative stress has been associated with the progression of atherosclerosis and activation of genes that lead to increased deposition of proteins in the extracellular matrix. Bone sialoprotein (BSP) and osteonectin are proteins involved in the initiation and progression of vascular calcification. Objective: To investigate the effect of oxidized low-density lipoprotein on osteonectin and BSP expression in human aorta vascular smooth muscle cells (HA/VSMCs). Methods: We treated HA/VSMCs with oxidized low-density lipoprotein (oxLDL) and measured the relative expression of osteonectin and BSP genes using the real-time polymerase chain reaction (PCR) method. We investigated the protein levels produced by each gene using the western blotting technique. Results: oxLDL increased osteonectin and BSP levels (mean SD], 9.1 2.1]-fold and 4.2 0.75]-fold, respectively) after 48 hours. The western blotting results also confirmed the increased levels of osteonectin and BSP. Conclusion: oxLDL may ...
In this study, we observed that increased SPARC expression is associated with the invasive phenotype in meningiomas, regardless of tumor histological grade. These results suggest that SPARC is a candidate marker to identify those potentially or actually invasive tumors that are otherwise histomorphologically benign and for which there is no tumor/brain invasive interface available for pathological assessment.. SPARC is a secreted, ECM-associated glycoprotein that is implicated in the modulation of cell adhesion, migration, and angiogenesis during development (6) . Increased expression has been associated with other cancer types (12, 13, 14) , suggesting that the inappropriate expression may contribute to cancer progression. We have demonstrated increased SPARC expression in tumor cells and neovessel endothelial cells of astrocytic tumors of all grades (10) . In addition, we have demonstrated SPARC expression in human glioblastoma cells invading rat brain in an in vivo model (10) . We therefore ...
Secreted protein and rich in cysteine (SPARC) is a matricellular glycoprotein which has been extensively associated with breast cancer progression, both in human tumors and in experimental models. However, the molecular mechanisms responsible for this effect are still unclear in particular because most studies were performed in immunocompromised nude mice. We undertook a comprehensive study of SPARC role in this disease by using the highly metastatic and poorly immunogenic 4T1 and LM3 mammary tumor cells syngeneic in Balb/c mice. Knock down of SPARC expression using a targeted shRNA in both cell lines greatly reduced primary tumor growth and completely obliterated the establishment of metastatic foci in lung. We performed global gene expression analysis comparing primary tumors and metastatic foci of control 4T1 cells with those arisen from shRNA-treated, SPARC-deficient 4T1 cells. From these studies, a potential role of the inflammatory/immune response in controlling tumor evasion and ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Structure and expression of SPARC (osteonectin, BM-40): a secreted Ca++-binding glycoprotein associated with extracellular matrix production. In: Morphoregulatory Molecules. Eds. Edelman, G.M., Cunnningham, B.A. and Thiery, J.-P ...
Acute lung injury is characterized by excessive extracellular matrix proteolysis and neutrophilic inflammation. A major risk factor for lung injury is bacterial pneumonia. However, host factors that protect against pathogen-induced and host-sustained proteolytic injury following infection are poorly understood. Pseudomonas aeruginosa (PA) is a major cause of nosocomial pneumonia and secretes proteases to amplify tissue injury. We show that thrombospondin-1 (TSP-1), a matricellular glycoprotein released during inflammation, dose-dependently inhibits PA metalloendoprotease LasB, a virulence factor. TSP-1-deficient (Thbs1-/-) mice show reduced survival, impaired host defense, and increased lung permeability with exaggerated neutrophil activation following acute intrapulmonary PA infection. Administration of TSP-1 from platelets corrects the impaired host defense and aberrant injury in Thbs1-/- mice. Although TSP-1 is cleaved into 2 fragments by PA, TSP-1 substantially inhibits Pseudomonas ...
Acute lung injury is characterized by excessive extracellular matrix proteolysis and neutrophilic inflammation. A major risk factor for lung injury is bacterial pneumonia. However, host factors that protect against pathogen-induced and host-sustained proteolytic injury following infection are poorly understood. Pseudomonas aeruginosa (PA) is a major cause of nosocomial pneumonia and secretes proteases to amplify tissue injury. We show that thrombospondin-1 (TSP-1), a matricellular glycoprotein released during inflammation, dose-dependently inhibits PA metalloendoprotease LasB, a virulence factor. TSP-1-deficient (Thbs1-/-) mice show reduced survival, impaired host defense, and increased lung permeability with exaggerated neutrophil activation following acute intrapulmonary PA infection. Administration of TSP-1 from platelets corrects the impaired host defense and aberrant injury in Thbs1-/- mice. Although TSP-1 is cleaved into 2 fragments by PA, TSP-1 substantially inhibits Pseudomonas ...
Purpose and History During prostate advancement mesenchymal-epithelial connections regulate body organ development and differentiation. in situ hybridisation display screen and researched Decorin (Dcn) Semaphorin6D (Sema6D) SPARC/Osteonectin (SPARC) Sprouty1 (Spry-1) and Tsukushi (Tsku). Appearance in rat SYN-115 tissue was examined using wholemount in situ hybridisation (postnatal time (P) 0.5) and immunohistochemistry (embryonic time (E) E17.5 E19.5; …Read More. ...
Blog on anti-SPARC antibody product: The SPARC sparc (Catalog #MBS2544117) is an Antibody produced from Rabbit and is intended for research p...
Goat Polyclonal SPARC antibody AA 18-303 for CyTOF, FACS, IHC, SimWes, WB. Published in 7 Pubmed References. Order this anti-SPARC antibody. | Product number ABIN4899340
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Objective: To investigate the effects and mechanisms of secreted protein, acidic and rich in cysteine (SPARC) on high fluoride-induced apoptosis of thyrocytes. Methods: Human thyroid cells (Nthy-ori 3-1) were cultured and treated with various concentrations (0.1, 1 and 10 mmol/L) of NaF for 24 h, and the expression of SPARC was evaluated using Real-time PCR and Western blot, respectively. The cells were divided into four groups: control group, NaF group, si-SPARC group (cells were transfected with SPARC siRNA for 48 h and then exposed to NaF for 24 h), and si-NC group (cells were transfected with negative control siRNA for 48 h and then exposed to NaF for 24 h). Cytotoxicity was assayed using CCK-8 and LDH; cell apoptosis rate was detected with ELISA. The expressions of cleaved caspase3 (c-caspase3) and IGF-1R were measured by Western blot. In addition, si-SPARC and si-IGF-1R were co-transfected into thyrocytes to further explore mechanisms of SAPRC by evaluating apoptosis. Results: The mRNA and ...
Mouse monoclonal to GSK3 alpha romantic relationship between SPARC and type 2 diabetes and its own complications shows that theres a specific relevance between SPARC as well as the occurrence of cardiovascular NSC 131463 system disease. The full total outcomes of the research verified that SPARC level in simplex type 2 diabetes group, cardiovascular system disease by itself group and type 2 diabetes coupled with cardiovascular system disease group had been greater than that in the standard control group, and it had been the best in type 2 diabetes sufferers with cardiovascular system disease; there have been no significant distinctions between basic type 2 diabetes group and cardiovascular system disease alone group, which was consistent with the conclusion of previous studies that SPARC may be associated with the onset of diabetes and its associated.. ...
Complete information for SPOCK2 gene (Protein Coding), SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
rs1859345 is a SNP in the - get ready - sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 SPOCK1 gene. A study of 477 Caucasian women, followed up by replication studies in another ~1,600 and also 1,300+ Chinese women, found that several linked SNPs in the SPOCK1 gene are associated with age at menarche. rs1859345 replicated across all groups studied (p , 10e-3), with the minor (C) allele associated with a (slightly) earlier age at menarche.[PMID 19282985 ...
SEA791Mu, SPARC; BM-40; Secreted Protein,Acidic,Cysteine-Rich; Basement-membrane protein 40; Secreted protein acidic and rich in cysteine | Products for research use only!
EPA ecosystems researchers in Athens, Ga., have developed a predictive modeling system known as SPARC (SPARC Performs Automated Reasoning in Chemistry) for estimating chemical reactivity parameters and physical properties for a wide range of organic molecules.. Although still under development, the SPARC modeling system is being designed to incorporate multiple mathematical approaches to estimate important chemical reactions and behavior. It will then interface directly with air, water, and land models to provide EPA with data that can inform risk assessments and prioritize toxicity-testing requirements for regulated chemicals.. SPARC is being designed to provide physical properties and chemical reactivity parameters describing factors for air, water and other environmental media needed to develop and apply models such as the Environmental Fate Simulator and Reaction Pathway Simulator. This will allow EPA scientists to use SPARC for characterizing complex processes that influence the reactivity ...
Dr. Villa-Diazs research focuses on understanding and elucidating the self-renewal properties of hPSCs, which are influenced by the microenvironment in which they are cultured, in particular the extracellular matrix (ECM). The ECM is a multifunctional regulator of cellular behavior serving functions beyond those as a scaffold for the organization of cells into tissues. ECM proteins modulate the activity and bioavailability of growth factors, cytokines, and chemokines via direct binding and signaling via cell-surface receptors including integrins and matricellular proteins, to regulate cellular functions ...
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KEYWORDS=~alpha ~amd64 ~arm ~hppa ~ia64 ~mips ~ppc ~ppc64 ~s390 ~sh ~sparc ~x86 ~amd64-fbsd ~x86-fbsd ~amd64-linux ~x86-linux ~ppc-macos ~x86-macos ~sparc64-solaris ...
Framework for lifting x86, amd64, aarch64, sparc32, and sparc64 program binaries to LLVM bitcode - mcsema/McSemaWalkthrough.md at master · lifting-bits/mcsema
w3cam (0.7.2-6.2+b4 [ppc64], 0.7.2-6.2+b3 [amd64, arm64, armel, armhf, i386, mips64el, mipsel, ppc64el, s390x], 0.7.2-6.2+b2 [alpha], 0.7.2-6.2+b1 [hppa, m68k, sh4, sparc64, x32], 0.7.2-6.2 [riscv64 ...
Abstract: : Purpose: To study the distribution of SPARC (secreted protein acidic and rich in cysteine) in the murine lens. SPARC has been shown to be an essential factor in the development and maintenance of lens transparency in mice because all SPARC-null mice begin to form cataract within 1 month after birth. It is therefore important to identify the localization and cellular expression of SPARC in the murine lens. Method: Immunohistochemistry and immunoblot analyses were conducted on murine lens capsule and on lens cells from E14 to 2 yr; steady-state levels of SPARC mRNA in lens cells were determined by RT-PCR. Results: Lens epithelium produced abundant SPARC as early as E14; the protein remained at high levels up to 2 yr of age. By immunohistochemistry and RT-PCR, the lens fiber cells at the equator were shown to contain SPARC, but not the secondary fibers located inside the bow region. The lens capsule did not contain SPARC. SPARC protein was also identified in the vitreous. Proteolytic ...
Osteonectin (OSN) is a glycoprotein which is implicated in development, bone formation and mineralisation, tumorigenesis, angiogenesis, and wound healing. Regulation of its expression by hormones may be one of the mechanisms by which the endocrine system affects bone metabolism. As a first step to understanding OSN function in fish, the gene expression of the recently cloned cDNA for sea bream, Sparus auratus, osteonectin (sbOSN) was characterised during embryonic and larval development. sbOSN mRNA was first detected by semi-quantitative reverse transcription-polymerase chain reaction in embryos at early gastrula and its expression increased continuously until hatch, after which it decreased until 15 days post-hatch (dph), increased transiently until 24 dph and decreased thereafter. In situ hybridisation showed it had a differential tissue distribution which was age dependent. In general, sbOSN mRNA was identified in cartilaginous and calcified structures of both dermal and endochondral origin ...
From NCBI Gene:. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]. From UniProt: ...
Results A single bout of exercise increased the expression and secretion of SPARC in skeletal muscle in both mice and humans. In addition, in an azoxymethane-induced colon cancer mouse model, regular low-intensity exercise significantly reduced the formation of aberrant crypt foci in wild-type mice but not in SPARC-null mice. Furthermore, regular exercise enhanced apoptosis in colon mucosal cells and increased the cleaved forms of caspase-3 and caspase-8 in wild-type mice but not in SPARC-null mice. Culture experiments showed that SPARC secretion from myocytes was induced by cyclic stretch and inhibited proliferation with apoptotic effect of colon cancer cells.. ...
Purpose and History During prostate advancement mesenchymal-epithelial connections regulate body organ development and differentiation. in situ hybridisation display screen and researched Decorin (Dcn) Semaphorin6D (Sema6D) SPARC/Osteonectin (SPARC) Sprouty1 (Spry-1) and Tsukushi (Tsku). Appearance in rat SYN-115 tissue was examined using wholemount in situ hybridisation (postnatal time (P) 0.5) and immunohistochemistry (embryonic time (E) E17.5 E19.5; P0.5; P6; 28 & adult). Four applicants (Decorin SPARC Spry-1 Tsukushi) had been immunolocalised in individual foetal prostate (weeks 14 16 19 and appearance of Decorin was examined on a individual prostate tumor tissues microarray. In embryonic and perinatal rats Decorin Semaphorin6D SPARC Spry-1 and Tsukushi had been expressed with differing distribution patterns through the entire mesenchyme at E17.5 E19.5 P0.5 and P6.5. In P28 and adult prostates there is either a reduction in the appearance (Semaphorin6D) or a change to epithelial appearance ...
The adverse health effects of exposure to asbestos are widely known and have been well documented. When a person is diagnosed with asbestosis, a chronic lung disease caused by inhaling asbestos fibers, few treatment options exist, none of which halt or reverse the progression of the disease. The rapidly growing field of gene therapy offers new avenues for potential treatments worthy of investigation. The detrimental effects of asbestos exposure are due to the physiological response of the lungs to asbestos fibers in the form of fibrosis, a result of excess extracellular collagen deposition. A protein called SPARC (Secreted Protein Acidic and Rich in Cysteine) has been identified in previous studies as being a matricellular protein involved in the fibrotic response following asbestos exposure. Using the principle of RNA interference, we aimed to knock down the expression of SPARC in our studies, hypothesizing that a reduction in SPARC expression would yield a reduction in fibrosis. In our in vitro
Testican-1 is a protein that in humans is encoded by the SPOCK1 gene. This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The proteins function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition. GRCh38: Ensembl release 89: ENSG00000152377 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000056222 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. Genomics. 48 (3): 377-80. doi:10.1006/geno.1997.5199. PMID 9545645. Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1. Périn JP, Alliel PM, Jollès P, Bonnet F (1994). ...
osteonectin. // Tabers Cyclopedic Medical Dictionary;2005, p1545 A definition of the medical term osteonectin is presented. Osteonectin refers to a glycoprotein present in the noncollagenous portion of the matrix bone. The definition is from the Tabers Cyclopedic Medical Dictionary, published by F.A. Davis Co. The pronunciation of the term is also provided. ...
Krock E, Millecamps M, Anderson KM, Srivastava A, Reihsen TE, Hari P, Sun YR, Jang SH, Wilcox GL, Belani KG, Beebe DS, Ouellet J, Pinto MR, Kehl LJ, Haglund L, Stone LS. Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model. EBioMedicine. 2019 Apr 29. pii: S2352-3964(19)30271-3. [link ...
زمینه و هدف: در کلسیفیه شدن دیواره رگ ها یک از عوامل مهم در پاتوژنز آترواسکلروز است و پروتئین های ماتریکس استخوان و فاکتورهای تنظیمی از جمله استئونکتین نقش اساسی در تشکیل آتروم و پیشرفت آترواسکلروز به عهده دارند. مطالعات نشان داده اند که مصرف آنتی اکسیدان ها سبب کاهش کلسیفیه شدن عروق و کاهش بروز بیماری های قلبی عروقی می گردند. در این مطالعه تاثیر اسید گالیک بر بیان ژن استئونکتین مورد بررسی قرار گرفت. روش بررسی: در این مطالعه تجربی، میزان مهارکنندگی 50 (IC50) اسید گالیک بر سلول های عضله صاف دیواره رگ ها در سلول های کشت شده تعیین گردید؛ سپس این سلول ها با غلظت ...
wearyellowforseth (1) 2joy-21 (1) A01 (2) A02 (2) A19 (1) A34 (3) A40 (1) acryl (13) acrylverf (100) Alcohol inks (19) Apipila-L18 (5) B.03 Mind Blown (4) B01 (1) B08 (1) B11 (1) B44 (1) Big SdP-B (17) Big SdP-B2 (2) Big SdP-G (7) Big SdP-K (13) Big SdP-O (7) Big SdP-T (2) Big SdP-V (4) birthday collab (1) BM 03 (1) BM-01 (1) BM-02 (4) BM-04 (5) BM-08 (1) BM-09 (1) BM-13 (4) BM-14 (2) BM-167 (1) BM-18 (1) BM-201 (2) BM-205 (2) BM-208 (2) BM-212 (1) BM-213 (1) BM-214 (2) BM-215 (1) BM-221 (2) BM-223 (1) BM-224 (3) BM-225 (3) BM-301 (1) BM-304 (1) BM-305 (5) BM-307 (2) BM-308 (1) BM-309 (3) BM-311 (1) BM-312 (1) BM-314 (2) BM-315 (1) BM-317 (1) BM-318 (3) BM-321 (3) BM-322 (1) BM-323 (1) BM-324 (2) BM-408 (1) BM-409 (1) BM-412 (1) BM-413 (1) BM-414 (1) BM-415 (1) BM-416 (1) BM-422 (1) BM-603 (1) BM-604 (1) BM-607 (1) BM-613 (1) BM-619 (1) BM-708 (1) BM-710 (1) bm-717 (1) BM-719 (1) BM-720 (1) BM-H01 (1) BM-H03 (3) BM-H04 (1) BM-H05 (1) BM-H06 (2) BM-H07 (1) BM-H08 (1) BM-H09 (1) BM-H12 (1) BM-H13 ...
wearyellowforseth (1) 2joy-21 (1) A01 (2) A02 (2) A19 (1) A34 (3) A40 (1) acryl (13) acrylverf (100) Alcohol inks (19) Apipila-L18 (5) B.03 Mind Blown (4) B01 (1) B08 (1) B11 (1) B44 (1) Big SdP-B (17) Big SdP-B2 (2) Big SdP-G (7) Big SdP-K (13) Big SdP-O (7) Big SdP-T (2) Big SdP-V (4) birthday collab (1) BM 03 (1) BM-01 (1) BM-02 (4) BM-04 (5) BM-08 (1) BM-09 (1) BM-13 (4) BM-14 (2) BM-167 (1) BM-18 (1) BM-201 (2) BM-205 (2) BM-208 (2) BM-212 (1) BM-213 (1) BM-214 (2) BM-215 (1) BM-221 (2) BM-223 (1) BM-224 (3) BM-225 (3) BM-301 (1) BM-304 (1) BM-305 (5) BM-307 (2) BM-308 (1) BM-309 (3) BM-311 (1) BM-312 (1) BM-314 (2) BM-315 (1) BM-317 (1) BM-318 (3) BM-321 (3) BM-322 (1) BM-323 (1) BM-324 (2) BM-408 (1) BM-409 (1) BM-412 (1) BM-413 (1) BM-414 (1) BM-415 (1) BM-416 (1) BM-422 (1) BM-603 (1) BM-604 (1) BM-607 (1) BM-613 (1) BM-619 (1) BM-708 (1) BM-710 (1) bm-717 (1) BM-719 (1) BM-720 (1) BM-H01 (1) BM-H03 (3) BM-H04 (1) BM-H05 (1) BM-H06 (2) BM-H07 (1) BM-H08 (1) BM-H09 (1) BM-H12 (1) BM-H13 ...
Different tumor microenvironments (TMEs) induce stromal cell plasticity that affects tumorigenesis. The impact of TME-dependent heterogeneity of tumor endothelial cells (TECs) on tumorigenesis is unclear. Here, we isolated pure TECs from human colorectal carcinomas (CRCs) that exhibited TMEs with either improved (Th1-TME CRCs) or worse clinical prognosis (control-TME CRCs). Transcriptome analyses identified markedly different gene clusters that reflected the tumorigenic and angiogenic activities of the respective TMEs. The gene encoding the matricellular protein SPARCL1 was most strongly upregulated in Th1-TME TECs. It was also highly expressed in ECs in healthy colon tissues and Th1-TME CRCs but low in control-TME CRCs. In vitro, SPARCL1 expression was induced in confluent, quiescent ECs and functionally contributed to EC quiescence by inhibiting proliferation, migration, and sprouting, whereas siRNA-mediated knockdown increased sprouting. In human CRC tissues and mouse models, vessels with ...
diff --git a/arch/sparc/kernel/of_device.c b/arch/sparc/kernel/of_device.c index c590148..4ef1607 100644 --- a/arch/sparc/kernel/of_device.c +++ b/arch/sparc/kernel/of_device.c @@ -344,6 +344,27 @@ static int __init build_one_resource(struct device_node *parent, return 1; } +static int __init use_1to1_mapping(struct device_node *pp) +{ + /* If we have a ranges property in the parent, use it. */ + if (of_find_property(pp, ranges, NULL) != NULL) + return 0; + + /* Some SBUS devices use intermediate nodes to express + * hierarchy within the device itself. These arent + * real bus nodes, and dont have a ranges property. + * But, we should still pass the translation work up + * to the SBUS itself. + */ + if (!strcmp(pp-,name, dma) ,, + !strcmp(pp-,name, espdma) ,, + !strcmp(pp-,name, ledma) ,, + !strcmp(pp-,name, lebuffer)) + return 0; + + return 1; +} + static int of_resource_verbose; static void __init build_device_resources(struct of_device *op, @@ -389,10 +410,7 @@ static void ...
This book describes the assembler that runs on the SPARC architecture and translates source files that are in assembly language format into object files in linking format. The text in this book is current to Solaris 7 software.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC): Comprehensive Functional Mapping of Neuroanatomy and Neurobiology of Organs (OT2) RFA-RM-15-018. Roadmap
In reply to Lars Wendler (Polynomial-C) from comment #1) , Arches please test and mark stable the following versions: , , =media-libs/libpng-1.2.54: , ~alpha amd64 ~arm arm64 ~hppa ~ia64 m68k ~mips ~ppc64 s390 sh ~sparc x86 , ~sparc-fbsd ~x86-fbsd ~amd64-linux ~x86-linux Most of these have no stable keywords on this SLOT. , =media-libs/libpng-1.5.24: , ~alpha amd64 ~arm ~arm64 ~hppa ~ia64 ~m68k ~mips ~ppc ~ppc64 ~s390 ~sh , ~sparc x86 ~amd64-fbsd ~sparc-fbsd ~x86-fbsd ~x64-freebsd ~x86-freebsd , ~x86-interix ~amd64-linux ~arm-linux ~x86-linux ~ppc-macos ~x64-macos , ~x86-macos ~m68k-mint ~sparc-solaris ~sparc64-solaris ~x64-solaris , ~x86-solaris ~x86-winnt Most of these have no stable keywords on this SLOT. , =media-libs/libpng-1.6.19: , alpha amd64 arm ~arm64 hppa ia64 ~m68k ~mips ppc ppc64 ~s390 ~sh sparc x86 , ~ppc-aix ~amd64-fbsd ~sparc-fbsd ~x86-fbsd ~x64-freebsd ~x86-freebsd , ~x86-interix ~amd64-linux ~arm-linux ~x86-linux ~ppc-macos ~x64-macos , ~x86-macos ~m68k-mint ~sparc-solaris ...
A SPARC Associate, in the constituency, works as a catalyst to mobilize resources from poorly performing government schemes by working through the office of the MP and activating key levers within the government system to make it more effective. Apart from the government schemes, the Associate also identifies and implements projects that can benefit the constituents by sourcing funds from either CSR or government programs.. OUR REACH. ...
AnalysisWhen Oracle announced the eight-core Sparc T4 processor and the four systems that make use of the new chip to run Solaris workloads two weeks ago, the one thing that was missing on announcement day was pricing for the systems. Having lived through Oracle OpenWorld, El Reg figures now is a good time to circle back and take a look at packaging and pricing for the Sparc T4 machines and how they stack up to prior generations of Sparc T-class iron ...
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上海凱倫BM-2013-KMB報站系統是一個由上海凱倫生產的自動巴士到站提示廣播系統,現時系統應用在全部九巴及龍運巴士現役巴士。 隨著GPS全球定位功能更加準確,九巴及龍運巴士決定在新購置的巴士安裝自動報站系統,以減輕車長工作量。…
Several lines of evidence point out that the trabecular meshwork ECM is indeed the source of aqueous humor outflow resistance, and that MMP-9 is a potent modulator of the trabecular meshwork architecture. Ultrastructural examinations of the trabecular meshwork of POAG patients reveal a shift in ECM composition as well as decreased MMP-9 activity, and a reciprocal interplay between both.32-34 Furthermore, overexpression of the matricellular protein SPARC in human anterior segment explant cultures results in elevated IOP and qualitative changes in the ECM of the trabecular meshwork (i.e., elevated collagen I, IV, and VI; laminin; and fibronectin levels) that could be linked to a shift in MMP/TIMP balance and a selective decrease in MMP-9 activity.33,35 This evidence for an important role for MMP-9 in IOP homeostasis has been corroborated by in vitro experiments using perfused human anterior segment organ cultures, to which addition of recombinant MMP-9 results in a reversible increase in outflow ...
Protein BM-1 (bahasa Inggris: procollagen C-peptidase, bone morphogenetic protein 1, mammalian tolloid, mTLD, procollagen C-proteinase, procollagen C-terminal proteinase; carboxyprocollagen peptidase; procollagen C-terminal peptidase; procollagen C-proteinase; procollagen C-terminal proteinase; procollagen carboxypeptidase; procollagen carboxy-terminal proteinase; procollagen peptidase, BMP-1, EC 3.4.24.19) merupakan enzim metaloprotease yang mengiris terminus-C pada posisi Ala-Asp pada prokolagen tipe I dan II, dan pada posisi arg-Asp pada prokolagen tipe III,[1] dalam proses aktivasi prekursor protein yang berperan dalam pembentukan jaringan matriks ekstraselular, termasuk aktivasi protelitik terhadap zimogen dari oksidase lisil.[2] Marimastat merupakan senyawa penghambat aktivitas BMP-1.[3] Aktivitas BMP-1 akan meningkat oleh kalsium, fibronektin,[2] sFRP,[4] dan sejenis glikoprotein dengan kofaktor berupa Zn,[5] Protein sFR merupakan target terapi fibrosis jantung.[4] ...
During progression of melanoma, malignant melanocytes can be reprogrammed into mesenchymal-like cells through a process similar to epithelial-mesenchymal transition (EMT), which is associated with downregulation of the junctional protein E-cadherin and acquisition of a migratory phenotype. Recent evidence supports a role for SLUG, a transcriptional repressor of E-cadherin, as a melanocyte lineage transcription factor that predisposes to melanoma metastasis. However, the signals responsible for SLUG expression in melanoma are unclear and its role in the invasive phenotype is not fully elucidated. Here, we report that SLUG expression and activation is driven by SPARC (also known as osteonectin), a secreted extracellular matrix-associated factor that promotes EMT-like changes. Ectopic expression or knockdown of SPARC resulted in increased or reduced expression of SLUG, respectively. SLUG increase occurred concomitantly with SPARC-mediated downregulation of E-cadherin and P-cadherin, and induction ...
Objective: To examine the hypothesis that degenerative aortic stenosis (AS) is associated with the development of blood vessels and the expression of the secreted protein, acidic and rich in cysteine/osteonectin (SPARC), a matricellular protein that is involved in ossification, the modulation of angiogenesis and the production of metalloproteinases.. Methods: 30 surgically excised AS valves and 20 normal aortic valves were studied.. Results: Blood vessels were detected in the aortic valves from patients with degenerative AS, whereas normal valves were avascular structures. Blood vessels in AS valves expressed endothelial nitric oxide synthase, CD34 and von Willebrand factor (vWF). Blood vessels were located in three distinct regions: near calcified nodules, under the leaflet border and in rich cellular areas forming cell islands. Blood vessels were predominantly present in early and intermediate grades of calcification. Cell islands were densely populated by CD45-positive cells where endothelial ...
TY - JOUR. T1 - Cardiac extracellular matrix remodeling: Fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC). AU - McCurdy, Sarah. AU - Baicu, Catalin F.. AU - Heymans, Stephane. AU - Bradshaw, Amy D.. PY - 2010/3. Y1 - 2010/3. KW - BM-40. KW - Osteonectin. KW - SPARC. KW - Extracellular matrix. KW - Remodeling. KW - Review. U2 - 10.1016/j.yjmcc.2009.06.018. DO - 10.1016/j.yjmcc.2009.06.018. M3 - Article. C2 - 19577572. VL - 48. SP - 544. EP - 549. JO - Journal of Molecular and Cellular Cardiology. JF - Journal of Molecular and Cellular Cardiology. SN - 0022-2828. IS - 3. ER - ...
Young (3 mo old) and old (18-24 mo old) wild-type (WT) and SPARC-null mice were studied. LV collagen content was measured histologically by collagen volume fraction, collagen composition was measured by hydroxyproline assay as soluble collagen (1 M NaCl extractable) versus insoluble collagen (mature cross-linked), and collagen morphological structure was examined by scanning electron microscopy ...
Historically, VEGFR-1 was assigned a role as a nonsignaling decoy receptor because of the low activity and embryonic dispensability of its tyrosine kinase function. More recently, its role has become more interesting because VEGFR-1 signaling has been reported both to promote (6, 7) and suppress (8) VEGF-A-driven angiogenesis. We report not only that PlGF-1 inhibits inflammatory CNV, extending the scope of VEGFR-1 function, but also what we believe is the unprecedented observation that VEGF-A itself can suppress angiogenesis. Multiple lines of evidence emerging from genetic ablation, antibody neutralization, and receptor-selective ligand activation all strongly support the thesis that the antiangiogenic action of VEGF-A is mediated by VEGFR-1. Previously, VEGF-A has been reported to reduce VEGF-E-induced VEGFR-2 tyrosine kinase phosphorylation in capillary endothelial cells in vitro, raising the provocative hypothesis that VEGF-A could limit its own angiogenic activity through VEGFR-1 (29). We ...
SMOC-1 and SMOC-2, two extracellular matrix proteins, were cloned as full length proteins but also as fragments that contained only single domains or the combination of three or four domains. The proteins were recombinantly expressed in eukaryotic cell lines, purified by affinity chromatography and used to immunize animals or to perform functional assays. An antiserum against SMOC-2 could be affinity purified with the help of the new recombinant proteins, which allowed the analysis of expression and tissue distribution of SMOC-2. In adult mouse, heart, spleen, thymus, ovary and, particularly, lung, kidney, cartilage and skin were found to be the organs where SMOC-2 is mainly expressed. During embryonic development SMOC-2 was first detected at basement membranes at embryonic day 7.5, but the expression was not limited to these structures. Starting at day 10.5 the distribution became broader and SMOC-2 was continuously present until adulthood. In zebrafish, the SMOCs were shown to be important ...
NetBSD/sparc is based on work done at Lawrence Berkeley Laboratory by the Computer Systems Engineering group under DARPA contract BG 91-66, which later appeared in the 4.4BSD-Lite distribution from the University of California, Berkeley. It was imported into the NetBSD source tree on October 2, 1993. Special thanks are extended to the LBL Computer Systems Engineering group for their work. Without which, this port would not exist. For frequently asked questions and links to Sun hardware information, see the NetBSD/sparc FAQ. For newer UltraSPARC-based machines, see NetBSD/sparc64. ...
Eldis editor Alan Stanley was invited to Abuja recently to attend the State Partnership for Accountability, Responsiveness and Capability (SPARC) end-of-programme learning event. Based on what he heard he highlights five key lessons from the programme on effective governance reform. Back in 2013, after some brief meetings and correspondence via email, Eldis began a content partnership with the State Partnership for Accountability, Responsiveness and Capability (SPARC).
Sparc in Mumbai -Contact details and more information from Sparc in Mumbai. Search through over 7564, NGOs database by State, City or Pincode.
Affiliation (Current):金沢大学,附属病院,助教, Research Field:Radiation science,Basic Section 52040:Radiological sciences-related, Keywords:神経芽腫,内照射療法,内用療法,放射線管理,matricellular protein,annexin V,α線,tenascin C,消化器癌,虚血性心疾患, # of Research Projects:7, # of Research Products:41, Ongoing Project:Development of new therapeutoc strategy for high-risk chemotherapy-refractory neuroblastoma
KEYWORDS=~alpha ~amd64 ~arm ~hppa ~ia64 ~mips ~ppc ~ppc64 ~s390 ~sh ~sparc ~x86 ~amd64-fbsd ~x86-fbsd ~x86-freebsd ~x86-interix ~amd64-linux ~x86-linux ~ppc-macos ~x64-macos ~x86-macos ~sparc-solaris ~sparc64-solaris ~x64-solaris ~x86-solaris ...
If I understand your description right, it sounds as if the POSIX model is incompatible with both of the old ways of switching between two euids: either using setreuid() to swap uid,-,euid, or using setuid() to switch from uid=0 to some other uid and being able to switch back later because the saved uid remembers that you are really root. (Do I misunderstand?) I can understand wanting to be POSIX compatible, but is it necessary to break binary compatibility? Especially on sparc or other legacy systems? (Could there be a kernel option to allow the old behavior?) As for the setreuid() routine, if its not going to work as expected, Id rather see it removed entirely from libc. That way, when porting code, you find out a link time rather than at run time. Keith ...
libreoffice-officebean (1:3.5.4+dfsg2-0+deb7u10 [amd64, armel, armhf, i386], 1:3.5.4+dfsg2-0+deb7u6 [kfreebsd-amd64, kfreebsd-i386, s390x], 1:3.5.4+dfsg2-0+deb7u5 [powerpc, s390], 1:3.5.4+dfsg2-0+deb7u4 [mipsel, sparc], 1:3.5.4+dfsg2-0+deb7u3 [mips], 1:3.5.4+dfsg2-0+deb7u2 [ia64]) [security ...