This article reviews the clinical behavior, histologic features, differential diagnosis, and treatment of a benign osteoblastoma. Benign osteoblastoma is a rare tumor constituting 1% of all primary bone tumors. Only 15% of osteoblastomas occur in the skull and jaw bones. The most common clinical presentation is a painful or tender swelling. A case is presented of a 21-year-old female who had noted discomfort for approximately 2 years, and the pain was not relieved by any analgesic. The choice of treatment was local excision and curettage. In this case, root resorption of the adjacent tooth, which is not a characteristic behavior of osteoblastoma, is seen ...
Osteoblastoma is a rare and benign osteoid-producing primary bone tumor that affects mainly the long bones. 36% of these tumors are observed around the spine and the vast majority arises around the posterior. This report describes a case of C3-4 osteoblastoma occurring in a 5-year-and-8-month-old Han Chinese child. The pathophysiology of symptom development, evaluations, and management are presented. Because of the close proximity of the osteoblastoma to the vertebral artery canal, the artery suffered a minor laceration intraoperatively. Hemostatic gelatin sponges were used to compress the bleeding site instantly and a tricortical iliac crest fixed with a screw was also used to add pressure to the gelatin sponges. Fusion on the other side was also used to stabilize the spine. To the best of our knowledge, this is the first report of a case of osteoblastoma at C3-4 with artery injury intraoperatively. This case delineates the difficulties in diagnosing this tumor, the challenges and problems encountered
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Osteoblastoma
Hamlet, S., Alfarsi, M., George, R. & Ivanovski, S., 2012, The effect of hydrophilic titanium surface modification on macrophage inflammatory cytokine gene expression, Clinical Oral Implants Research, 23(5), pp. 584-90. K Bokhari, MS Hameed, M Ajmal, RA Togoo Benign osteoblastoma involving maxilla: a case report and review of the literature Case reports in dentistry 2012 Haralur SB, Gana NS, Al-Dowah, et al. Quantitative evaluation on the ability of dental plaque adherence to commonly used provisional crowns. JIOH Sep-Dec2012,4(3).
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Osteoblastomas are rare and benign primary bone tumours. They may be locally aggressive and tend to affect the axial skeleton more often than their histologic relative, osteoid osteoma. Epidemiology They account for 1-3% of all primary bone tum...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Mardaleishvili, Konstantine and Kakabadze, Zurab and Machavariani, Avtandil and Grdzelidze, Teimuraz and Kakabadze, Anna and Sukhitashvili, Natia and Kurashvili, Tamar and Shonia, Nestan and Menabde, Giorgi and Abiatari, Ivane (2014) Benign osteoblastoma of the mandible in a 12-year-old female: A case report. Oncology letters, 8 (6). pp. 2691-2694. ISSN 1792-1074 Kakabadze, Zurab and Abiatari, Ivane and Makashvili, Malkhaz and Karashvili, Lia and Kakabadze, Anna (2014) Anatomical Justification for the Use of Human Placenta as a Host for in Vivo Cell and Tissue Transplantation. Asian Journal of Pharmacy, Nursing and Medical Sciences (ISSN: 2321 - 3639) Volume 02 - Issue 01, February 2014. De Oliveira, Tiago and Abiatari, Ivane and Raulefs, Susanne and Sauliunaite, Danguole and Erkan, Mert and Kong, Bo and Friess, Helmut and Michalski, Christoph W and Kleeff, Jörg (2012) Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype. ...
LAS VEGAS - At the American Academy of Orthopaedic Surgeons Annual Meeting, Joseph H. Schwab, MD, spoke about the management of vertebral fractures caused by spinal metastases. He said pain may not always come from the fracture, but from the cancer. ...
There is reactive sclerosis with a nidus that is barely visible on the radiograph (blue arrow), but clearly visible on the CT (red arrows).. CT scan is usually very helpful in detecting the nidus and differentiating osteoid osteoma from other sclerotic lesions like osteoblastoma, osteomyelitis, arthritis, stress fracture and enostosis.. MRI also may detect the nidus, combined with abundant bone marrow and soft tissue edema ...
Study Design Case report. Objective We report the youngest child diagnosed with upper cervical osteoblastoma and the first case operated on with our novel surgical approach. Methods Our patient underwent a two-stage surgery. During the first operation via a posterior approach, a subtotal resection of a C2 bony mass was performed. C3 was also subtotally resected due to tumor extension. Posterior fixation of C1-C5 was performed by C1 sublaminar hooks and C4 and C5 lateral mass screws. Ten days later, a total resection of the residual bony mass was performed through an anterior approach (between the sternocleidomastoid muscle and carotid sheath ...
PDF Similar Articles Mail to Author Mail to Editor Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature Benjamin D. ELDER, C. Rory GOODWIN, Thomas A. KOSZTOWSKI, Sheng-Fu L. LO, Ali BYDON, Jean-Paul WOLINSKY, George I. JALLO, Ziya L. GOKASLAN, Timothy F. WITHAM, Daniel M. SCIUBBA ...
PDF Similar Articles Mail to Author Mail to Editor Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature Benjamin D. ELDER, C. Rory GOODWIN, Thomas A. KOSZTOWSKI, Sheng-Fu L. LO, Ali BYDON, Jean-Paul WOLINSKY, George I. JALLO, Ziya L. GOKASLAN, Timothy F. WITHAM, Daniel M. SCIUBBA ...
Osteoid osteoma and osteoblastoma are uncommon benign bone tumors which originate from osteoblasts in animals. Both tumors have similar characteristics. Osteoid osteoma..
Surgical navigation, though well-established, is often associated with extra effort for both patient and surgeon, and with additional exposure to radiation as a result of the necessary extra imaging. Osteoblastoma is a benign bone tumour, malignant transformation of which is rare but possible, and so resection is indicated. The orbit with surrounding structures is a challenging region for accurate three-dimensional reconstruction. A virtual plan based on the patients mirrored anatomy realised by intraoperative navigation can assist in achieving perfect results. An 8-year-old boy presented with a huge osteoblastoma of the frontal and temporal skull. The tumour had extracranial and intracranial parts, and reached into the orbital roof and the sphenoid and ethmoid bones. The ethmoid sinus was involved, the eye was displaced, and he had functional problems. Virtual planning and navigation were prepared without the need for any additional imaging. The tumour was resected through a coronal approach, ...
A prosthetic replacement for a posterior element of a vertebra comprising portions that replace the natural lamina and the four natural facets. The prosthetic replacement may also include portions that replace one or more of the natural spinous process and the two natural transverse processes. If desired, the prosthesis replacement may also replace the natural pedicles. A method for replacing a posterior element of a vertebra is also provided.
A prosthetic replacement for a posterior element of a vertebra comprising portions that replace the natural lamina and the four natural facets. The prosthetic replacement may also include portions that replace one or more of the natural spinous process and the two natural transverse processes. If desired, the prosthesis replacement may also replace the natural pedicles. A method for replacing a posterior element of a vertebra is also provided.
Parathyroid hormone (PTH), a polypeptide consisting of 84 amino acids that is synthesized and secreted by the parathyroid glands, is a principal regulator of calcium homeostasis through concerted action on kidney, intestine and bone. Parathyroid hormone exerts its action on bone to release calcium into the extracellular fluid as a process of bone remodeling and also to maintain the serum calcium concentration, but the exact mechanisms are not fully understood. In some circumstances, PTH may exert an anabolic action on bone and can stimulate osteoblast proliferation and mature osteoblast function. The net effect of exogenous PTH administration on bone turnover depends on the pattern of delivery. A continuous long-term infusion gives a net decrease in trabecular bone volume, whereas daily single injections result in a net increase.. NPS Allelix Corp. is developing ALX1-11, recombinant human parathyroid hormone (1-84), for the treatment of osteoporosis. ALX1-11 is identical to the endogenous intact ...
Recombinant Human Parathyroid Hormone is a single, non-glycosylated, 15N stable isotope labeled polypeptide chain containing 78 amino acids. Background: Parathyroid hormone (PTH) is a single polypeptide of 78 amino acids. It is a critical hormone in the r
Green Cross was developing recombinant human parathyroid hormone (rhPTH) for the treatment of osteoporosis. Phase II clinical trials had been completed in
Scoliosis caused by osteoid osteomas are typically non-flexible curves where the osteoid osteoma occurs on the concavity of the curve. While peripheral osteoid osteomas, far away from the neural elements CAN be treated with radiofrequency ablation, treating osteoid osteomas of the spine with RFA needs to be done on a case by case basis - depending on how close the lesion is to the neural elements. Osteoid osteomas can occur in either the vertebral body or the posterior elements of the spine, but typically occur in the posterior elements. Histologically, osteoid osteomas of the spine are identical to those in the extremity. ...
On 27 July the US Food and Drug Administration held a public hearing on an application for a licence for the use of recombinant human parathyroid hormone in the treatment of postmenopausal osteoporosis. The application, from Eli Lilly, is for teriparatide (Forsteo), the N-terminal fragment rhPTH(1-34). The hearings advisory panel voted unanimously in favour of the parathyroid hormone and approval could be expected after resolution of a few technical concerns. The application was partly based on solid evidence that parathyroid hormone, given as a daily injection for several weeks or months in experimental animals, increases bone mass and strength.1 This evidence led to a multicentre randomised controlled trial in women with osteoporosis, which showed that treatment with parathyroid hormone reduced spine fractures by 66% to 90% (according to whether smaller fractures and those causing minor symptoms were counted) and other fractures by 50%.2. The first experiments showing an anabolic effect of ...
Teriparatide (recombinant human parathyroid hormone [1-34]) is an anabolic agent approved for the treatment of patients at high risk for fracture. The Fracture Prevention Trial administered teriparati
The FDAs Endocrinologic and Metabolic Drugs Advisory Committee voted to recommend approval of recombinant human parathyroid hormone for hypoparathyroidism.
Background Osteoid osteoma is a benign osteoblastic tumor that Bergstrand first described in 1930. Jaffe described it in 1935 and was the first to recognize it as a unique entity.
Category General Spine Aaron Baer, MD Mohannad Ibrahim, MD Colin McKnight, MD Hemant Parmar, MD Purpose The purpose of this educational exhibit is to examine the characteristic imaging features, epidemiology, and clinical presentations of common solitary osseous lesions of the spine. Materials & Methods The following osseous lesions of the spine were compared in terms of their characteristic imaging features, typical anatomic distributions, patient demographics, and clinical presentations: aneurysmal bone cyst, chordoma, enostosis, eosinophilic granuloma, Ewing sarcoma, giant cell tumor, hemangioma, lymphoma, metastases, myeloma, osteoblastoma, osteoid osteoma, osteomyelitis, osteosarcoma, and Paget disease. Patient cases were collected and graphic illustrations were used to demonstrate the unique imaging characteristics of each entity and the similarities among them. Results There are several solitary osseous lesions which have unique imaging features (e.g. hemangioma), patient demographics ...
Osteoid osteoma is a painful, benign bony tumor affecting a predominantly young patient population, with 60% occurring between ages 10 and 20 years old and a male predominance.
Osteogenic sarcoma is the sixth leading cancer in children under age 15 and it corresponds to approximately 20% of all bone cancers. Complete radical surgical en bloc resection is the treatment of choice in osteosarcoma. This case was discussed ...
... - Dans les blocs sino-auriculaires chroniques et dans la maladie rythmique auriculaire, il existe en revanche des lésions sévères du nœud sinusal parfois.
Ten (10 %) percent of cancer patients with Metastatic Tumors to the Spine have NO PREVIOUS KNOWN CANCER and of these, SPINAL CORD COMPRESSION AND PAIN ARE THE FIRST SIGNS AND SYMPTOMS OF THE DISEASE. VERTEBRAL COLUMN TUMORS. Spinal Bone Tumors involve the bony Vertebral Column and can be divided into Cancerous Tumors and Benign Tumors. Cancerous Spinal Bone Tumors include Metastatic Cancers and Primary Bone Cancers.. A. Metastatic Spinal Bone Tumors Any type of cancer can spread to Spinal Bones; however, the most common ones are cancers of LUNG, BREAST, PROSTATE and KIDNEY as well as LYMPHOMAS.. B. Primary Cancerous Spinal Bone Tumors. These Tumors are relatively uncommon and include Chordomas, Chondrosarcomas, Osteogenic Sarcomas, Ewings Sarcomas, Multiple Myelomas, Lymphomas etc. Treatments for these malignant tumors must involve multimodality measures which, includes surgery, chemotherapy and radiation.. C. Benign Spinal Bone Tumors. These Tumors include Osteoid Osteomas, Osteoblastomas, ...
Abstract The case of a relatively frequent benign osteoblastic tumour, osteoid osteoma at an atypical site is presented. It was in a 20 year old man who attended the outpatient department of Aga Khan University Hospital, Karachi with pain in left groin since last 6 months which often occurred at night and was relieved by taking NSAIDs. X-ray failed to reveal the cause. CT scan showed central radiolucent nidus with surrounding sclerosis suggestive of osteoid osteoma in the left acetabulum. Acetabulum is a rare site for osteoid osteoma, the usual sites are diaphysis of long bones. Hence, the diagnosis is often difficult and delayed in such cases. CT scan, Bone scan and MRI, helped in diagnosing the condition. Resection of the lesion by open technique under fluoroscopic control was performed and histopathology confirmed the diagnosis.
For patients undergoing spine fusion surgery, non-fusion (or pseudarthrosis) is one of the major complications that can lead to poor clinical outcomes. Therefore, treatments that promote or augment fusion are highly desirable. Teriparatide (Forteo, recombinant human parathyroid hormone [1-34]) is a systemically administered peptide hormone that is FDA-approved for the treatment of osteoporosis in postmenopausal women or other populations at high risk for fracture. While teriparatide has been shown to enhance spinal fusion in several rodent and rabbit studies, no clinical studies to date have examined its effect on spinal fusion in humans.. This single-site two-year prospective randomized double-blind placebo-controlled study is designed to examine the effects of peri-operative teriparatide treatment in older adults undergoing multi-level posterolateral lumbar spine fusion. All eligible patients seen at the UCSF Spine Center will be invited to enroll in the study. Upon enrollment, patients will ...
Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy. Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues ...
MEDIGO lists clinics around the world offering Benign Bone Tumor Removal procedures from $ 838. Save up to 80% on Orthopedics treatment abroad.
Osteoid osteoma of the acetabulum can be expected to cause nonspecific symptoms of hip inflammation. In a sixteen year old girl, investigation by routine r
Operative schema for total en bloc spondylectomy.(A) Pediculotomy using a T-saw and en bloc resection of the posterior element; (B) Anterior column osteotomy an
Why attempt en bloc resection of non-pedunculated colorectal adenomas? A systematic review of the prevalence of superficial submucosal invasive cancer after endoscopic submucosal dissection ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Vertebral bodies L2-L5 show increased opacity from osteoblastic metastases (orange arrows). Incidental age-related DJD (degenerative Joint Disease) with osteop
Martinez, R., Morais, D., Ramirez, B., Martinez, P., Benito, J.I. (2003) Osteoma of the mastoid. Acta Otorrinolaringol Esp, 54, 94-97.
Expertise, Disease and Conditions: Aneurysmal Bone Cyst, Back Pain, Cauda Equina Syndrome, Cavernous Angioma, Cervical Degenerative Disc Disease, Cervical Degenerative Disc Herniation, Cervical Disc Herniation, Cervical Myelopathy, Cervical Radiculopathy, Cervical Spine Trauma, Cervical Spondylosis, Chiari Malformations, Chordomas, Chrondrosarcoma, Cranio-cervical Junction Pathology, Degenerative Disc Disease, Degenerative Spine Disease, Disc Pain, Giant Cell Tumor, Hemangioblastoma, Hemangiomas, Kyphosis, Lumbar Degenerative Disease, Lumbar Disc Herniation, Lumbar Radiculopathy, Minimally Invasive Spine Surgery, Minimally Invasive Surgery, Myxopapillary Ependymoma, Neck Pain, Nerve Sheath Tumor, Neurosurgery, Neurosurgical Oncology, Osteoblastoma, Osteoid Osteoma, Radiculopathy, Sacral Tumors, Sarcoma, Schwannoma, Sciatica, Spinal Column Tumors, Spinal Cord Injury, Spinal Cord Malformation, Spinal Cord Tumors, Spinal Decompression, Spinal Deformities, Spinal Dural Fistula, Spinal Ependymoma, ...
Expertise, Disease and Conditions: Aneurysmal Bone Cyst, Back Pain, Cauda Equina Syndrome, Cavernous Angioma, Cervical Degenerative Disc Disease, Cervical Degenerative Disc Herniation, Cervical Disc Herniation, Cervical Myelopathy, Cervical Radiculopathy, Cervical Spine Trauma, Cervical Spondylosis, Chiari Malformations, Chordomas, Chrondrosarcoma, Cranio-cervical Junction Pathology, Degenerative Disc Disease, Degenerative Spine Disease, Disc Pain, Giant Cell Tumor, Hemangioblastoma, Hemangiomas, Kyphosis, Lumbar Degenerative Disease, Lumbar Disc Herniation, Lumbar Radiculopathy, Minimally Invasive Spine Surgery, Minimally Invasive Surgery, Myxopapillary Ependymoma, Neck Pain, Nerve Sheath Tumor, Neurosurgery, Neurosurgical Oncology, Osteoblastoma, Osteoid Osteoma, Radiculopathy, Sacral Tumors, Sarcoma, Schwannoma, Sciatica, Spinal Column Tumors, Spinal Cord Injury, Spinal Cord Malformation, Spinal Cord Tumors, Spinal Decompression, Spinal Deformities, Spinal Dural Fistula, Spinal Ependymoma, ...
{use-layout:ORTHOMAIN} An Atlas of Musculoskeletal Oncology James O. Johnston 3rd Edition, March 09 Preface to the First Edition Preface to the Second Edition Preface to the Third Edition Contents Volume 1 Benign Bone Tumors Osteoid osteoma Cases 1-50 Ost
{use-layout:ORTHOMAIN} An Atlas of Musculoskeletal Oncology James O. Johnston 3rd Edition, March 09 Preface to the First Edition Preface to the Second Edition Preface to the Third Edition Contents Volume 1 Benign Bone Tumors Osteoid osteoma Cases 1-50 Ost
Strictly defined, osteoma cutis refers to the presence of bone within the skin in the absence of a preexisting or associated lesion. This is opposed to secondary types of cutaneous ossification that can occur in reaction to inflammatory, traumatic, and neoplastic processes.
The bony mass had a cartilage cap and the tentative diagnosis of an osteochondroma was made. The patient was not known to have any other exostoses.. Intra-operatively a bony mass with a cartilage cap was found, compressing the L5 and S1 spinal root. The mass was excised and sent for histology. A laminectomy was done.. The histology confirmed an osteochondroma.. Discussion. Of all spinal tumours, 70% of primary bone tumours are benign. These include osteoid osteomas, osteoblastomas, giant cell tumours, osteochondromas, aneurysmal bone cysts, eosinophilic granulomas and fibrous dysplasias.1. Osteochondromas (also known as osteocartilaginous exostoses)2 encompass 10-15% of all bone tumours3 and 36% of all benign bone tumours.4 Primary tumours of the spine are relatively infrequent when compared to lymphoma of the spine, myeloma and multiple myeloma.5. Osteochondromas are solitary (often) and are cartilaginous bony growths, usually appearing in relation to the epiphyseal growth plate.6 They can be ...
LAUBSCHER, M; HELD, M e DUNN, RN. Primary bone tumours of the spine: Presentation, surgical treatment and outcome. SA orthop. j. [online]. 2015, vol.14, n.2, pp.22-28. ISSN 2309-8309. http://dx.doi.org/10.17159/2309-8309.. BACKGROUND: Primary bone tumours of the spine are a group of rare tumours that include both benign and malignant lesions. Resection is associated with a high morbidity rate. METHODS: We retrospectively reviewed all the primary bone tumours of the spine that were surgically treated at our unit between 2005 and 2012 (haematological malignancies were excluded. RESULTS: Fifteen cases were included that presented at a median age of 36 years (range 8 to 65 years). Pain was the most common presenting symptom. Three patients had significant neurological deficits at time of presentation and in two cases there was an improvement after surgery. The median delay in diagnosis was 7 months (range 1 to 36 months). A variety of surgical strategies was employed with the use of adjuvant radio- ...
There are many benign bone tumors that require clinical care by a physician or other healthcare professional. Listed in the directory below are some, for which we have provided a brief overview.. If you cannot find the information in which you are interested, please visit the Bone Disorders Online Resources page in this Web site for an Internet/World Wide Web address that may contain additional information on that topic.. ...
Hi Dr West,. I had diagnosed on Mar 2012, with mets to brain and bone.I am EGFR+ with 19 deletion. I took Tarceva since Apr 2012 and had great responses. On Nov 2012, with still multiple tumors on my brain, I started pulsed Tarceva - I took 7 pills (150mg each) all at once on a day, then waited for 6 days. With less side effect, my brain mets(about 6-,7 of them, with largest 10mm) totally disappeared on Apr 2013s scan. I continue taking pulsed tarceva since then.. Last week my CT scan shows small new appeared lung nodules (largest 3.5mm) and one slightly increased old nodule ( from 1.5mm to 3 mm), with SUV of max 1.3. And my PET scan showed extensive increase activities (suv 3.5) on my left sacral ala, corresponding to a 12mm sclerotic lesion. I am now switched back to daily 150mg Tarceva since last visit and was told to wait for 3 more month for scan.. My question is: does this mean a tarceva resistance? Or it is caused by long period of pulsed tarceva? What might happen next after I switch ...