Aggressive osteoblastoma is a rare bone-forming neoplasm composed of prominent epithelioid cells that demonstrate locally invasive growth with a high rate of recurrence but no metastatic potential. Clinical, radiographic and pathologic features of mandibular aggressive osteoblastoma in a 21-year-old African-American male and a 12-year-old Caucasian female are presented. Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy. The patients showed no evidence of local recurrence or distant spread either clinically or radiographically after two years of follow-up. These tumors were composed of solid sheets of pleomorphic epithelioid cells, eosinophilic amorphous osteoid with foci of calcification, which closely simulated amyloid. Differentiation of this tumor from histologically similar calcifying epithelial odontogenic tumor and low-grade osteosarcoma proved difficult. Immunohistochemical study with osteocalcin confirmed the osteoblastic ...

Osteoblastoma is a rare and benign tumor which requires early diagnosis and surgical excision. Scoliosis is a common presentation following osteoblastoma. It is considered due to pain-provoked muscle spasm on the side of the lesion. Few researches about osteoblastoma combined with severe scoliosis have been reported. A 14-year-old girl presents with progressive scoliosis deformity for 3 years, with gradually appeared low back pain and numbness of left leg. Radiographic results showed osteoblastic mass at the left side of L3-L4 with severe scoliosis deformity, pelvic obliquity and spinal imbalance. The patient underwent posterior tumor excision, spinal decompression, scoliosis correction, spinal fusion with auto-graft and instrumentation from T8-S1. The mass was found to be osteoblastoma. The patient had a full neurological recovery with no aggravate of scoliosis or spinal imbalance during the follow-up. This case emphasizes the importance of early diagnosis and surgical treatment of osteoblastoma. Early

This article reviews the clinical behavior, histologic features, differential diagnosis, and treatment of a benign osteoblastoma. Benign osteoblastoma is a rare tumor constituting 1% of all primary bone tumors. Only 15% of osteoblastomas occur in the skull and jaw bones. The most common clinical presentation is a painful or tender swelling. A case is presented of a 21-year-old female who had noted discomfort for approximately 2 years, and the pain was not relieved by any analgesic. The choice of treatment was local excision and curettage. In this case, root resorption of the adjacent tooth, which is not a characteristic behavior of osteoblastoma, is seen ...

Osteoblastoma is a rare and benign osteoid-producing primary bone tumor that affects mainly the long bones. 36% of these tumors are observed around the spine and the vast majority arises around the posterior. This report describes a case of C3-4 osteoblastoma occurring in a 5-year-and-8-month-old Han Chinese child. The pathophysiology of symptom development, evaluations, and management are presented. Because of the close proximity of the osteoblastoma to the vertebral artery canal, the artery suffered a minor laceration intraoperatively. Hemostatic gelatin sponges were used to compress the bleeding site instantly and a tricortical iliac crest fixed with a screw was also used to add pressure to the gelatin sponges. Fusion on the other side was also used to stabilize the spine. To the best of our knowledge, this is the first report of a case of osteoblastoma at C3-4 with artery injury intraoperatively. This case delineates the difficulties in diagnosing this tumor, the challenges and problems encountered

TY - JOUR. T1 - Osteoblastoma of the foot and ankle. AU - Temple, H. Thomas. AU - Mizel, Mark S.. AU - Murphey, Mark D.. AU - Sweet, Donald E.. PY - 1998/10. Y1 - 1998/10. N2 - A total of 329 patients with osteoblastoma were retrospectively reviewed from the archives of the Armed Forces Institute of Pathology, of which 41 (12.5%) presented with tumors in the foot and ankle. This was the third most common site of disease after the spine and femur. Overall, the mean age was 22.5 years, which was the same for the foot and ankle subset of patients; however, there was a significant male predominance in foot and ankle patients compared with the whole group. The majority of patients were skeletally mature (85.4%). Clinically, most patients presented with pain (97.2%), although one-third of the total related a history of antecedent trauma. The interval between the onset of symptoms and biopsy was 84 days (range, 0-572 days). Radiographically, the majority of lesions were in the hindfoot (N = 18; 44%) of ...

From the first biopsy until the surgical resection, the athlete was on crutches and was partial weight-bearing. Following the resection, she was completely non-weight-bearing for two weeks to minimize the load on the plate and screws in her pelvis. After those two weeks, she was partial weight-bearing. At 4-weeks, pelvic X-rays were taken, and the subject progressed to weight-bearing as tolerated. Initially, her physical therapist advised she perform light hip/pelvis stretching and passive ROM exercises. Athletic trainers assumed oversight of her rehabilitation upon arrival at college. Her rehabilitation protocol was guided largely by existing protocols from hip labral repair and ACL-reconstruction focusing on strengthening the hip, hamstrings, and core. The athletes criteria to return-to-play (RTP), as established by her physician, included full practice sessions performed at 100% effort without symptom provocation. She has successfully returned to play 2-years out from her surgical resection ...

Fingerprint Dive into the research topics of Magnetic resonance-guided focused ultrasound surgery treatment of non-spinal intra-articular osteoblastoma: feasibility, safety, and outcomes in a single-center retrospective analysis. Together they form a unique fingerprint. ...

Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Osteoblastoma

Hamlet, S., Alfarsi, M., George, R. & Ivanovski, S., 2012, The effect of hydrophilic titanium surface modification on macrophage inflammatory cytokine gene expression, Clinical Oral Implants Research, 23(5), pp. 584-90. K Bokhari, MS Hameed, M Ajmal, RA Togoo Benign osteoblastoma involving maxilla: a case report and review of the literature Case reports in dentistry 2012 Haralur SB, Gana NS, Al-Dowah, et al. Quantitative evaluation on the ability of dental plaque adherence to commonly used provisional crowns. JIOH Sep-Dec2012,4(3).

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.

Osteoblastomas are rare and benign primary bone tumours. They may be locally aggressive and tend to affect the axial skeleton more often than their histologic relative, osteoid osteoma. Epidemiology They account for 1-3% of all primary bone tum...

UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.

Mardaleishvili, Konstantine and Kakabadze, Zurab and Machavariani, Avtandil and Grdzelidze, Teimuraz and Kakabadze, Anna and Sukhitashvili, Natia and Kurashvili, Tamar and Shonia, Nestan and Menabde, Giorgi and Abiatari, Ivane (2014) Benign osteoblastoma of the mandible in a 12-year-old female: A case report. Oncology letters, 8 (6). pp. 2691-2694. ISSN 1792-1074 Kakabadze, Zurab and Abiatari, Ivane and Makashvili, Malkhaz and Karashvili, Lia and Kakabadze, Anna (2014) Anatomical Justification for the Use of Human Placenta as a Host for in Vivo Cell and Tissue Transplantation. Asian Journal of Pharmacy, Nursing and Medical Sciences (ISSN: 2321 - 3639) Volume 02 - Issue 01, February 2014. De Oliveira, Tiago and Abiatari, Ivane and Raulefs, Susanne and Sauliunaite, Danguole and Erkan, Mert and Kong, Bo and Friess, Helmut and Michalski, Christoph W and Kleeff, Jörg (2012) Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype. ...

LAS VEGAS - At the American Academy of Orthopaedic Surgeons Annual Meeting, Joseph H. Schwab, MD, spoke about the management of vertebral fractures caused by spinal metastases. He said pain may not always come from the fracture, but from the cancer. ...

There is reactive sclerosis with a nidus that is barely visible on the radiograph (blue arrow), but clearly visible on the CT (red arrows).. CT scan is usually very helpful in detecting the nidus and differentiating osteoid osteoma from other sclerotic lesions like osteoblastoma, osteomyelitis, arthritis, stress fracture and enostosis.. MRI also may detect the nidus, combined with abundant bone marrow and soft tissue edema ...

Study Design Case report. Objective We report the youngest child diagnosed with upper cervical osteoblastoma and the first case operated on with our novel surgical approach. Methods Our patient underwent a two-stage surgery. During the first operation via a posterior approach, a subtotal resection of a C2 bony mass was performed. C3 was also subtotally resected due to tumor extension. Posterior fixation of C1-C5 was performed by C1 sublaminar hooks and C4 and C5 lateral mass screws. Ten days later, a total resection of the residual bony mass was performed through an anterior approach (between the sternocleidomastoid muscle and carotid sheath ...

PDF Similar Articles Mail to Author Mail to Editor Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature Benjamin D. ELDER, C. Rory GOODWIN, Thomas A. KOSZTOWSKI, Sheng-Fu L. LO, Ali BYDON, Jean-Paul WOLINSKY, George I. JALLO, Ziya L. GOKASLAN, Timothy F. WITHAM, Daniel M. SCIUBBA ...

PDF Similar Articles Mail to Author Mail to Editor Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature Benjamin D. ELDER, C. Rory GOODWIN, Thomas A. KOSZTOWSKI, Sheng-Fu L. LO, Ali BYDON, Jean-Paul WOLINSKY, George I. JALLO, Ziya L. GOKASLAN, Timothy F. WITHAM, Daniel M. SCIUBBA ...

PDF Similar Articles Mail to Author Mail to Editor Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature Benjamin D. ELDER, C. Rory GOODWIN, Thomas A. KOSZTOWSKI, Sheng-Fu L. LO, Ali BYDON, Jean-Paul WOLINSKY, George I. JALLO, Ziya L. GOKASLAN, Timothy F. WITHAM, Daniel M. SCIUBBA ...

PDF Similar Articles Mail to Author Mail to Editor Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature Benjamin D. ELDER, C. Rory GOODWIN, Thomas A. KOSZTOWSKI, Sheng-Fu L. LO, Ali BYDON, Jean-Paul WOLINSKY, George I. JALLO, Ziya L. GOKASLAN, Timothy F. WITHAM, Daniel M. SCIUBBA ...

Lin YC, Commins D, Fedenko AN, Pinsky GS. A rare case of periosteal osteoblastoma located in the frontal cranial bone. Archives of Pathology & Laboratory Medicine [Internet]. 2005 ;129(6):787-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15913430 ...

Osteoid osteoma and osteoblastoma are uncommon benign bone tumors which originate from osteoblasts in animals. Both tumors have similar characteristics. Osteoid osteoma..

Surgical navigation, though well-established, is often associated with extra effort for both patient and surgeon, and with additional exposure to radiation as a result of the necessary extra imaging. Osteoblastoma is a benign bone tumour, malignant transformation of which is rare but possible, and so resection is indicated. The orbit with surrounding structures is a challenging region for accurate three-dimensional reconstruction. A virtual plan based on the patients mirrored anatomy realised by intraoperative navigation can assist in achieving perfect results. An 8-year-old boy presented with a huge osteoblastoma of the frontal and temporal skull. The tumour had extracranial and intracranial parts, and reached into the orbital roof and the sphenoid and ethmoid bones. The ethmoid sinus was involved, the eye was displaced, and he had functional problems. Virtual planning and navigation were prepared without the need for any additional imaging. The tumour was resected through a coronal approach, ...

Introduction: Spinal Koch involving posterior elements of the neural arch is one of the atypical presentations which are often missed. Case presentation: A 40-year-old female presented with radiculopathy and bilateral lower limb claudication for 5 months. Radiological investigations showed compressive lesion resembling flavum hypertrophy and a degenerative etiology was thus suspected. However, histopathology report pointed toward tuberculosis (TB) of the posterior elements (atypical form). Management with surgical decompression and anti-Koch treatment gave a successful outcome. Conclusion: TB affecting posterior elements of spine is a rare entity and needs a high degree of suspicion for accurate diagnosis. Newer radiological interventions such as computed tomography and magnetic resonance imaging along with histopathological evidence will help to clinch the diagnosis of Kochs spine early before neurological problems or deformity sets in. Keeping a high index of suspicion will help to avoid missing the

A prosthetic replacement for a posterior element of a vertebra comprising portions that replace the natural lamina and the four natural facets. The prosthetic replacement may also include portions that replace one or more of the natural spinous process and the two natural transverse processes. If desired, the prosthesis replacement may also replace the natural pedicles. A method for replacing a posterior element of a vertebra is also provided.

A prosthetic replacement for a posterior element of a vertebra comprising portions that replace the natural lamina and the four natural facets. The prosthetic replacement may also include portions that replace one or more of the natural spinous process and the two natural transverse processes. If desired, the prosthesis replacement may also replace the natural pedicles. A method for replacing a posterior element of a vertebra is also provided.

Parathyroid hormone (PTH), a polypeptide consisting of 84 amino acids that is synthesized and secreted by the parathyroid glands, is a principal regulator of calcium homeostasis through concerted action on kidney, intestine and bone. Parathyroid hormone exerts its action on bone to release calcium into the extracellular fluid as a process of bone remodeling and also to maintain the serum calcium concentration, but the exact mechanisms are not fully understood. In some circumstances, PTH may exert an anabolic action on bone and can stimulate osteoblast proliferation and mature osteoblast function. The net effect of exogenous PTH administration on bone turnover depends on the pattern of delivery. A continuous long-term infusion gives a net decrease in trabecular bone volume, whereas daily single injections result in a net increase.. NPS Allelix Corp. is developing ALX1-11, recombinant human parathyroid hormone (1-84), for the treatment of osteoporosis. ALX1-11 is identical to the endogenous intact ...

Recombinant Human Parathyroid Hormone is a single, non-glycosylated, 15N stable isotope labeled polypeptide chain containing 78 amino acids. Background: Parathyroid hormone (PTH) is a single polypeptide of 78 amino acids. It is a critical hormone in the r

Green Cross was developing recombinant human parathyroid hormone (rhPTH) for the treatment of osteoporosis. Phase II clinical trials had been completed in

Scoliosis caused by osteoid osteomas are typically non-flexible curves where the osteoid osteoma occurs on the concavity of the curve. While peripheral osteoid osteomas, far away from the neural elements CAN be treated with radiofrequency ablation, treating osteoid osteomas of the spine with RFA needs to be done on a case by case basis - depending on how close the lesion is to the neural elements. Osteoid osteomas can occur in either the vertebral body or the posterior elements of the spine, but typically occur in the posterior elements. Histologically, osteoid osteomas of the spine are identical to those in the extremity. ...

On 27 July the US Food and Drug Administration held a public hearing on an application for a licence for the use of recombinant human parathyroid hormone in the treatment of postmenopausal osteoporosis. The application, from Eli Lilly, is for teriparatide (Forsteo), the N-terminal fragment rhPTH(1-34). The hearings advisory panel voted unanimously in favour of the parathyroid hormone and approval could be expected after resolution of a few technical concerns. The application was partly based on solid evidence that parathyroid hormone, given as a daily injection for several weeks or months in experimental animals, increases bone mass and strength.1 This evidence led to a multicentre randomised controlled trial in women with osteoporosis, which showed that treatment with parathyroid hormone reduced spine fractures by 66% to 90% (according to whether smaller fractures and those causing minor symptoms were counted) and other fractures by 50%.2. The first experiments showing an anabolic effect of ...

Teriparatide (recombinant human parathyroid hormone [1-34]) is an anabolic agent approved for the treatment of patients at high risk for fracture. The Fracture Prevention Trial administered teriparati

The FDAs Endocrinologic and Metabolic Drugs Advisory Committee voted to recommend approval of recombinant human parathyroid hormone for hypoparathyroidism.

Background Osteoid osteoma is a benign osteoblastic tumor that Bergstrand first described in 1930. Jaffe described it in 1935 and was the first to recognize it as a unique entity.

Motamedi D, Learch TJ, Ishimitsu DN, Motamedi K, Katz MD, Brien EW, et al. Thermal ablation of osteoid osteoma: overview and step-by-step guide. Radiographics. 2009 Nov;​29(7):​2127-41. [[http://​www.ncbi.nlm.nih.gov/​pubmed/​19926767,PubMed ...

Category General Spine Aaron Baer, MD Mohannad Ibrahim, MD Colin McKnight, MD Hemant Parmar, MD Purpose The purpose of this educational exhibit is to examine the characteristic imaging features, epidemiology, and clinical presentations of common solitary osseous lesions of the spine. Materials & Methods The following osseous lesions of the spine were compared in terms of their characteristic imaging features, typical anatomic distributions, patient demographics, and clinical presentations: aneurysmal bone cyst, chordoma, enostosis, eosinophilic granuloma, Ewing sarcoma, giant cell tumor, hemangioma, lymphoma, metastases, myeloma, osteoblastoma, osteoid osteoma, osteomyelitis, osteosarcoma, and Paget disease. Patient cases were collected and graphic illustrations were used to demonstrate the unique imaging characteristics of each entity and the similarities among them. Results There are several solitary osseous lesions which have unique imaging features (e.g. hemangioma), patient demographics ...

Define en bloc resection. en bloc resection synonyms, en bloc resection pronunciation, en bloc resection translation, English dictionary definition of en bloc resection. n. Surgical removal of all or part of an organ, tissue, or structure. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016...

Osteoid osteoma is a painful, benign bony tumor affecting a predominantly young patient population, with 60% occurring between ages 10 and 20 years old and a male predominance.

Osteogenic sarcoma is the sixth leading cancer in children under age 15 and it corresponds to approximately 20% of all bone cancers. Complete radical surgical en bloc resection is the treatment of choice in osteosarcoma. This case was discussed ...

BLOC SINO AURICULAIRE PDF - Dans les blocs sino-auriculaires chroniques et dans la maladie rythmique auriculaire, il existe en revanche des lésions sévères du nœud sinusal parfois.

Ten (10 %) percent of cancer patients with Metastatic Tumors to the Spine have NO PREVIOUS KNOWN CANCER and of these, SPINAL CORD COMPRESSION AND PAIN ARE THE FIRST SIGNS AND SYMPTOMS OF THE DISEASE. VERTEBRAL COLUMN TUMORS. Spinal Bone Tumors involve the bony Vertebral Column and can be divided into Cancerous Tumors and Benign Tumors. Cancerous Spinal Bone Tumors include Metastatic Cancers and Primary Bone Cancers.. A. Metastatic Spinal Bone Tumors Any type of cancer can spread to Spinal Bones; however, the most common ones are cancers of LUNG, BREAST, PROSTATE and KIDNEY as well as LYMPHOMAS.. B. Primary Cancerous Spinal Bone Tumors. These Tumors are relatively uncommon and include Chordomas, Chondrosarcomas, Osteogenic Sarcomas, Ewings Sarcomas, Multiple Myelomas, Lymphomas etc. Treatments for these malignant tumors must involve multimodality measures which, includes surgery, chemotherapy and radiation.. C. Benign Spinal Bone Tumors. These Tumors include Osteoid Osteomas, Osteoblastomas, ...

Abstract The case of a relatively frequent benign osteoblastic tumour, osteoid osteoma at an atypical site is presented. It was in a 20 year old man who attended the outpatient department of Aga Khan University Hospital, Karachi with pain in left groin since last 6 months which often occurred at night and was relieved by taking NSAIDs. X-ray failed to reveal the cause. CT scan showed central radiolucent nidus with surrounding sclerosis suggestive of osteoid osteoma in the left acetabulum. Acetabulum is a rare site for osteoid osteoma, the usual sites are diaphysis of long bones. Hence, the diagnosis is often difficult and delayed in such cases. CT scan, Bone scan and MRI, helped in diagnosing the condition. Resection of the lesion by open technique under fluoroscopic control was performed and histopathology confirmed the diagnosis.

For patients undergoing spine fusion surgery, non-fusion (or pseudarthrosis) is one of the major complications that can lead to poor clinical outcomes. Therefore, treatments that promote or augment fusion are highly desirable. Teriparatide (Forteo, recombinant human parathyroid hormone [1-34]) is a systemically administered peptide hormone that is FDA-approved for the treatment of osteoporosis in postmenopausal women or other populations at high risk for fracture. While teriparatide has been shown to enhance spinal fusion in several rodent and rabbit studies, no clinical studies to date have examined its effect on spinal fusion in humans.. This single-site two-year prospective randomized double-blind placebo-controlled study is designed to examine the effects of peri-operative teriparatide treatment in older adults undergoing multi-level posterolateral lumbar spine fusion. All eligible patients seen at the UCSF Spine Center will be invited to enroll in the study. Upon enrollment, patients will ...

Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy. Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues ...

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Osteoid osteoma of the acetabulum can be expected to cause nonspecific symptoms of hip inflammation. In a sixteen year old girl, investigation by routine r

Operative schema for total en bloc spondylectomy.(A) Pediculotomy using a T-saw and en bloc resection of the posterior element; (B) Anterior column osteotomy an

Why attempt en bloc resection of non-pedunculated colorectal adenomas? A systematic review of the prevalence of superficial submucosal invasive cancer after endoscopic submucosal dissection ...

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...

Vertebral bodies L2-L5 show increased opacity from osteoblastic metastases (orange arrows). Incidental age-related DJD (degenerative Joint Disease) with osteop

Martinez, R., Morais, D., Ramirez, B., Martinez, P., Benito, J.I. (2003) Osteoma of the mastoid. Acta Otorrinolaringol Esp, 54, 94-97.