Affinity-purified antibodies that recognize Thymidylate Synthase (TS), Dihydropyrimidine Dehydrogenase (DPD), and Orotate Phosphoribosyltransferase (OPRT) that can be used for Western blot or immunohistochemistry
Affinity-purified antibodies that recognize Thymidylate Synthase (TS), Dihydropyrimidine Dehydrogenase (DPD), and Orotate Phosphoribosyltransferase (OPRT) that can be used for Western blot or immunohistochemistry
TY - JOUR. T1 - Motional dynamics of the catalytic loop in OMP synthase. AU - Wang, Gary P.. AU - Cahill, Sean M.. AU - Liu, Xiaohong. AU - Girvin, Mark E.. AU - Grubmeyer, Charles. PY - 1999/1/5. Y1 - 1999/1/5. N2 - In de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase catalyzes the formation of orotidine 5-monophosphate (OMP) from orotic acid and α-D-5-phosphoribosyl-1-pyrophosphate (PRPP). The known three- dimensional structure of the dimeric enzyme from Salmonella typhimurium is similar to that of other Type I phosphoribosyltransferases (nucleotide synthases) with a solvent-exposed active site atop a Rossman-type nucleotide binding fold. The three-dimensional structure of an enzyme - inhibitor complex [Henriksen et al. (1996) Biochemistry 35, 3803-3809] indicates that of the two identical solvent-exposed loops can descend to cover the active site of the adjacent subunit of the dimeric enzyme. Catalytically essential residues are known to reside on this loop. In the present ...
Edema & Jaundice & Sloping Shoulders Symptom Checker: Possible causes include Orotate Phosphoribosyltransferase Deficiency. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
However, many of the miscarriages occurring in this period are not related to sexual intercourse, but happen as a result of genetic deformations in the baby growing the womb. Major complications, such as pneumonia and meningitis, are more likely to occur in patients with a compromised immune system, i.e., patients with HIV/AIDS or patients receiving chemotherapy for cancer. All of the nutrients the fetus receives come directly from the mothers blood. It gets easier every time. But a minor group, the Rh Negative lacks these proteins. Retrieved June 17, 2016. Chlamydia can cause permanent damage to a females reproductive system, making it difficult or impossible to get pregnant.. The mummification process usually makes bacterial and viral analysis, biopsy, and chromosome analysis a futile exercise.25 Deoxyribonucleic acid (DNA) extracted from mummified fetuses revealed that two of ten were carriers (heterozygous) of the autosomal-recessive gene for deficiency of uridine monophosphate synthase ...
Buy Potassium Orotate 150 mg - Potassium Orotate contains potassium, one of the most abundant minerals in the human body. Increases the strength - Satisfaction guaranteed, Rewards Program discount, Top European Brand - Supersmart.com.
Magnesium Orotate is scientifically formulated and developed to give optimum benefit. Bone is living tissue, and to help… by HealthAid from the Health Shop at WWSM
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes. Gene targeting frequency in the type II Δku80 Δhxgprt strain measured at the orotate (OPRT) and the uracil (UPRT) phosphoribosyltransferase loci was highly efficient. To assess the potential of the type II Δku80 Δhxgprt strain to examine gene function affecting cyst biology and latent stages of infection, we targeted the deletion of four parasite antigen genes (GRA4, GRA6, ROP7, and tgd057) that encode characterized CD8(+) T cell epitopes that elicit corresponding antigen-specific CD8(+) T cell populations associated with control of infection ...
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Sigma-Aldrich offers abstracts and full-text articles by [Silvia N Mirica, Oana M Duicu, Simona L Trancota, Ovidiu Fira-Mladinescu, Denis Angoulvant, Danina M Muntean].
Lithium Orotate: Find the most comprehensive real-world treatment information on Lithium Orotate at PatientsLikeMe. 27 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, systemic lupus erythematosus, post-traumatic stress disorder, rheumatoid arthritis, Parkinsons disease, bipolar disorder, high blood pressure (hypertension), panic disorder, myalgic encephalomyelitis/chronic fatigue syndrome, amyotrophic lateral sclerosis, persistent depressive disorder (dysthymia), epilepsy, migraine, hypothyroidism, osteoarthritis, high cholesterol (hypercholesterolemia), attention deficit/hyperactivity disorder, bipolar II disorder, asthma, traumatic brain injury, social anxiety disorder, irritable bowel syndrome, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, gastroesophageal reflux disease or bipolar I disorder currently take Lithium Orotate.
Patient with orotic aciduria may present with symptoms and signs such as neurological disorders, failure to thrive, anemia, pallor, weakness and lethargy. Orotic aciduria may lead to accumulation of orotic acid which impair the synthesis of nuclei acid
Relevant Papers 1. Yablonski, M. J., Pasek, D. A., Han, B.-D., Jones, M. E., & Traut, T. W. (1996) Intrinsic activity and stability of bifunctional UMP synthase, and of its two separate domains, orotate phosphoribosyl-transferase and orotidine-5-phosphate decarboxylase. J. Biol. Chem.271, 10704-10708. 2. Traut, T.W. (1994) Dissociation of enzyme oligomers: A mechanism for allosteric regulation. CRC Crit. Rev. Biochem. Mol. Biol.29, 125-163. 3. Matthews, M.M., Liao, W., Kvalnes-Krick, K.L., and Traut, T.W. (1992) Beta-alanine Synthase: Purification and allosteric properties. Arch. Biochem. Biophys. 293, 254-263. ...
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Source: The Health Benefits of Calcium Orotate by Dr. Edward Group The human body has a need for calcium. Calcium enables us to have strong bones and prevents bone loss diseases such as osteoporosis. The effects of depleted calcium levels span far beyond the scope of weakened bones.Studies done at the Osteoporosis Research Center at Creighton…
1DQW: Anatomy of a proficient enzyme: the structure of orotidine 5-monophosphate decarboxylase in the presence and absence of a potential transition state analog.
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Lithium orotate, is a salt of orotic acid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissociates in solution to produce free lithium ions. It is marketed as a dietary supplement, though only barely researched between 1973-1986 to treat certain medical conditions, such as alcoholism and Alzheimers disease. While lithium orotate is capable of providing lithium to the body, like lithium carbonate and other lithium salts, there are no systematic reviews supporting the efficacy of lithium orotate and it is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of any medical condition. In 1973, Nieper reported that lithium orotate contained 3.83 mg of elemental lithium per 100 mg and lithium carbonate contained 18.8 mg of elemental lithium per 100 mg Nieper went on to claim that lithium did not dissolve from the orotate ...
Uridine Monophosphate Disodium Salt Nootropic Uridine monophosphate, also known as 5′-uridylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside uridine. UMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase uracil; hence, it is a ribonucleotide monophosphate. As a substituent or radical its name takes the form
The other disorders involve defects in the pyrimidine degradative pathway. Deficiency of pyrimidine-5′-nucleotidase causes hemolytic anemia, possibly due to accumulation in erythrocytes of pyrimidine nucleotides, mostly uridine triphosphate (UTP) and cytidine triphosphate (CTP). The disorder is transmitted in an autosomal recessive manner, and there is no specific treatment available. Pyrimidine 5′-nucleotidase superactivity has been described in four unrelated patients with developmental delay and neurologic abnormalities. The patients were treated with uridine with good effect. Deficiency of dihydropyrimidine dehydrogenase causes an increase in blood and urine levels of uracil and thymine. This deficiency is detected in a variety of clinical situations including pediatric metabolic screens for neurologic and other problems and adverse reactions to 5-fluorouracil, and is also found in asymptomatic relatives of detected patients. The enzyme deficiency is transmitted in an autosomal recessive ...
(KudoZ) Italian to English translation of cromo orotato, carbossimetilcellulosa: 1. chromium orotate 2. carboxyl methylcellulose [Medical].
Potassium is involved in the regulation of fluid and acidbase balances in blood and tissues. Orotic acid is a biochemical substance made naturally by the human
[65 Pages Report] Check for Discount on Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Intracal is a high quality form of magnesium and calcium orotate. Orotates are mineral salts made from orotic acid and used in the synthesis of DNA and RNA. These mineral salts assist in the transport of calcium through cellular membrane structures, facilitating the intracellular absorption of calcium especially in bones. Intracal is a calcium oratate […]. ...
MetabolismPurines, pyrimidines, nucleosides, and nucleotidesPyrimidine ribonucleotide biosynthesisorotidine 5-phosphate decarboxylase (TIGR01740; EC 4.1.1.23; HMM-score: 207.2) ...
This study was designed to determine the possible mechanism by which orotic acid exerts its mitoinhibitory effect on rat hepatocytes in primary culture. Orotic acid inhibited, dose-dependently DNA synthesis in hepatocytes induced by epidermal growth
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APPLIED ORGANOMETALLIC CHEMISTRY, VOL. 6, 229-239 (1992) The anti-neoplastic activity of ethylaminecarboxyborane and triphenylphosphinecarboxyborane in L- I 210 lymphoid leukemia cells Iris H Hall, E Stacy Hall, L K Chi,* M C Miller 111, Ken F Bastow, A Soodt and B F Spielvogelt *Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, NC 27599-7360, USA and tBoron Biologicals Inc., 533 Pylon Drive, PO Box 33489, Raleigh, NC 27636-3489, USA Studies on the mode of action of two boroncontaining anti-neoplastic agents, ethylaminecarboxyborane and triphenylphosphinecarboxyborane, are reported. The major site of inhibition was in the pyrimidine de AOUO synthetic pathway at orotidine monophosphate decarboxylase activity. Additional sites which may facilitate the inhibition of cell growth were IMP dehydrogenase, thymidine kinase, TMP kinase and TDP kinase, m-RNA, r-RNA and t-RNA polymerase activities as well as topoisomerase I1 activity. The reduction ...
Oral chelation formlation with EDTA. Oral chelation: helps prevent hardening of the arteries; helps rejuvenate your cardiovascular system; improves circulation; helps remove lead, mercury, plus 20 other metals; reduces toxic lead and metal deposits and abnormal calcium deposits; improves liver function and kidney function; helps relieve symptoms of memory loss by increasing circulation of the brain; and, helps dissolve fats in plaque lined arteries. Oral Chelation Nutritional Complex with Ayurvedic Herbal BlendSix capsules supply:Vitamin A (retinyl palmitate) 10,000 I.UVitamin C (as ascorbic acid and zinc ascorbate) 640 mg.Elemental Potassium 210 mg.From Potassium Aspartate 684 mg.From Potassium Orotate 300 mg.Elemental Magnesium 330 mg.From Magnesium Aspartate 1400 mg.From Magnesium Orotate 714 mg.Elemental Zinc 25 mg.From Zinc Ascorbate 168 mgElemental Selenium 70 mcg.From Selenium Ascorbate 70 mg.Sodium 28 mg.EDTA (Ethylenediamine tetra-acetic acid) 800 mg.Disodium EDTA 200 mg.L-Glutathione, reduced
Block, J B.; Chlebowski, R T.; and Dietrich, M, "Warfarin (w) and vitamin k (vk) effects on tumor growth and on pyrimidine biosynthetic pathway activity in vitro. Abstr." (1981). Subject Strain Bibliography 1981. 532 ...
2′-Deoxycytidine 5′-monophosphate (dCMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form dCDP which upo
An advanced broad-spectrum Magnesium supplement providing 300mg of elemental magnesium from Aspartate, Orotate, Chelate, Phosphate and Oxide forms of Magnesium.
Orotic acid, first discovered in ruminant milk, is an intermediate in the pyrimidine biosynthesis pathway of animal cells. Its synthesis is initiated by the formation of carbamoyl phosphate (CP) in the cytoplasm, with ammonia derived from glutamine.
Dihydroorotate dehydrogenase (DHODH) is the fourth enzyme of the de novo pyrimidine biosynthesis pathway which has been extensively studied in trypanosomatids using a combination of genetic, biochemical and structural studies. DHODH catalyzes the oxidation of L-dihydroorotate to orotate, a redox reaction, the only one to do so in the pathway. DHODH in trypanosomatids has emerged as a crucial enzyme of the pyrimidine pathway, as the null mutants of TcDHODH and knockdown strains of TbDHODH displayed retarded growth phenotypes, confirming the crucial presence of DHODH in the pathway. However, the DHODH null background in T. cruzi could not be rescued by the supplementation of uridine, cytidine and thymidine. The non-reversal of the functional loss of DHODH by the pyrimidine supplemention was attributed to additional fumarate reductase activity of TcDHODH, which maintains the redox balance of the parasite [30]. TcDHODH was presumed to be a fumarate reductase owing to its close resemblance with S. ...
Bioorganic. Catalysis based on the fundamentals of natural enzymes and proteins is the new frontier of green and efficient synthesis. Enzymatic acceleration ranges from 105 in Cyclophilin to 1017 in Orotidine monophosphate decarboxylases ("A proficient enzyme." Science 1995, 267, 90-93) The dramatic miniaturization of natures enzymes into catalytic peptides is a significant achievement in modern synthetic chemistry and biology. Structural preorganization in the transition states is critical for imbuing reactivity and selectivity ("Asymmetric Catalysis Mediated by Synthetic Peptides." Chem. Rev. 2007, 107, 5759-5812). However, these factors are poorly understood for peptide catalysis due to the large size, conformational flexibility and weakness of the interactions responsible for preorganization and transition state stabilization. By quantifying these factors using our strategies and tools, we will begin to create theories that govern the selectivities of these reactions and eventually ...
Ingredients per 4 capsules: Magnesium complex (Magnesium Orotate, Magnesium L-Theonate, Magnesium Citrate, Magnesium AA Chelate, Magnesium Krebs) 1300 mg, Vitamin C 250 mg, Vitamin B6 208 mg, Vitamin B6 (P5P) 33 mg, Vitamin B3 17 mg, Vitamin B12 0.333 mg, Zinc Picolinate (20%) 208 mg, Vitamin D3 (Cholicalciferol) 800 IU, Vitamin E 83 mg, Manganese Citrate 42 mg, Boron (Amino Acid chelate) 33 mg, Iodine (Potassium iodide) 8 mg, Biotin 8 mg, Lithium Orotate 8 mg, Germanium 132 8 mg, Molybedenum (Amino Acid chelate) 1.7 mg, Selenium (Selenomethionine) .02 mg, GTF Chromium 2.5% 1.7 mg ...
isotetrandrine drug combination cycleanine cepharanthine berbamine: an extract consisting of cepharanthine, cycleanine, isotetrandrine, and berbamine; isolated from Stephania cepharantha
The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] ...
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ABSTRACT The PaEXG2 gene, encoding an exo-beta-1,3-glucanase, was isolated from the biocontrol agent Pichia anomala strain K… Expand ...
Controlled proteolysis of the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells: evidence for discrete structural domains.: The
MetabolismPurines, pyrimidines, nucleosides, and nucleotidesSalvage of nucleosides and nucleotideshypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 22.2) ...
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Accepted name: UMP kinase. Reaction: ATP + UMP = ADP + UDP. Other name(s): uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA Systematic name: ATP:UMP phosphotransferase Comments: This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9036-23-1. References:. 1. Serina, L., Blondin, C., Krin, E., Sismeiro, O., Danchin, A., Sakamoto, H., Gilles, A.M. and B̢rzu O. Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP. Biochemistry 34 (1995) 5066-5074. [PMID: 7711027]. 2. Marco-Marin, C., Gil-Ortiz, F. and Rubio, V. The crystal structure of ...