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Abstract: The present study is undertaken to evaluate the antimicrobial properties of a new Fixed Dose Combination (FDC) of Ofloxacin Ornidazole for infusion against some aerobic bacteria in comparison with Ofloxacin and Ornidazole individually. Antibiotic Susceptibility Test (AST) and Minimum Inhibitory Concentration (MIC) of FDC of Ofloxacin Ornidazole, Ofloxacin and Ornidazole for P. aeruginosa, S. aureus, E. coli, K. pneumoniae, S. epidermis and MRSA were determined by disc method and broth micro dilution method. In Antimicrobial Susceptibility Test, lytic zone of combination was found to be more than Ofloxacin or Ornidazole alone in all microbial strains under study. The MIC value of FDC of Ofloxacin Ornidazole was found to be higher than both Ofloxacin and Ornidazole. The data suggests that fixed dose combination of Ofloxacin and Ornidazole can be a good option for use in mixed microbial infection of aerobic bacteria, anaerobic bacteria and pathogenic protozoans. ...

Ornidazole is an anti-infective, antibacterial and antiprotozoal drug. For effective relief of numerous infections, order Ornidazole today and experience better health!Ornidazole is als...

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Infections caused by more than one type of organisms are called as mixed infections and the best therapeutic option for their treatment is to combine two different drugs with different mechanism of action. O2 is a combination of ofloxacin and ornidazole. Ofloxacin is second generation fluoro-quinolone antibiotic which inhibits bacterial DNA gyrase enzyme, interfering in the synthesis of DNA in the bacteria and shows bactericidal action. Ornidazole is a newer nitroimidazoles with superior efficacy and longer duration of action. It kills susceptible microorganisms by interfering with DNA functioning. Hence combination of these two drugs shown higher efficacy, broad antimicrobial spectrum, least incidence of side effects and both are well tolerated ...

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Imidazole derivatives (e.g. metronidazole and ornidazole) in formulations for vaginal administration are classified in this group. Parenteral formulations are classified in J01XD, as they are mainly used in anaerobic infections. Imidazole derivatives in oral (including tablets used for the treatment of gynecological infections only) and rectal dosage forms are classified in P01AB. Metronidazole for topical use in skin disorders is classified in D06BX - Other chemotherapeutics ...

Imidazole derivatives (e.g. metronidazole and ornidazole) in formulations for vaginal administration are classified in this group. Parenteral formulations are classified in J01XD, as they are mainly used in anaerobic infections. Imidazole derivatives in oral (including tablets used for the treatment of gynecological infections only) and rectal dosage forms are classified in P01AB. Metronidazole for topical use in skin disorders is classified in D06BX - Other chemotherapeutics. ...

Blood in stool occur because of many causes. One of the cause is fissure-in-ano. Fissure in ano means cut into anal mucosa. This occur because of hard motion. When a child is suffering from constipation, he tries to pass the hard motion resulting into cut in anal mucosa. This may lead to bleeding while passing subsequent motion & severe pain. The child cries or tries to hold the motion because of fear of pain. It again leads to more constipation & the cycle becomes vicious. On examination, there is redness & fissure (cut) in the anal mucosa. The immediate treatment is oral laxatives to make the motion soft, local application of analgesic jelly & oral metronidazole/ ornidazole, dietary modification. Long term treatment is dietary modification. Diet should contain high fiber diet, green leafy vegetables, milk intake should be less & lot of water. It helps to make the stool soft. The junk foods containing bread, pizza etc should be avoided. Avoid spicy food & lot of milk. If the child is older, ...

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Objective: To study the protective effect of lipoic acid (LA) on the spermatogenic function of the male rats with oligoasthenozoospermia induced by ornidazole (ORN). METHODS: Seventy male SD rats were equally randomized into groups A (solvent control: 1 ml 0.5% CMC-Na + 1 ml olive oil), B (low-dose ORN model: 400 mg/kg ORN suspension + 1 ml olive oil), C (low-dose ORN + low-dose LA treatment: 400 mg/kg ORN + 50 mg/kg LA), D (low-dose ORN + high-dose LA treatment: 400 mg/kg ORN + 100 mg/kg LA), E (high-dose ORN model: 800 mg/kg ORN suspension + 1 ml olive oil), F (high-dose ORN + low-dose LA treatment: 800 mg/kg ORN + 50 mg/kg LA), and G (high-dose ORN + high-dose LA treatment: 800 mg/kg ORN + 100 mg/kg LA), and treated respectively for 20 successive days. Then all the rats were sacrificed and the weights of the body, testis, epididymis and seminal vesicle obtained, followed by calculation of the organ index, determination of epididymal sperm concentration and motility, and observation of the ...

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in Journal of Chromatography. A (2006), 1112(1-2), 156-164. A quantitative densitometric high-performance thin-layer chromatography (HPTLC) method was developed for the determination of glucosamine in a dietary supplement containing dried extracts of the main ... [more ▼]. A quantitative densitometric high-performance thin-layer chromatography (HPTLC) method was developed for the determination of glucosamine in a dietary supplement containing dried extracts of the main plants traditionally used for rheumatic disorders. The HPTLC method was chosen in order to circumvent the tedious and time-consuming sample preparation steps necessarily performed before using HPLC methods when analysing complex matrixes. Glucosamine was separated from the plant extracts on a silica gel 60 F(254) HPTLC plate using a saturated mixture of 2-propanol-ethyl acetate-ammonia solution (8%) (10:10:10, v/v/v). The plates were developed vertically up to a distance of 80 mm. For visualization, the plate was dipped into a ...

in Journal of Chromatography. A (2006), 1112(1-2), 156-164. A quantitative densitometric high-performance thin-layer chromatography (HPTLC) method was developed for the determination of glucosamine in a dietary supplement containing dried extracts of the main ... [more ▼]. A quantitative densitometric high-performance thin-layer chromatography (HPTLC) method was developed for the determination of glucosamine in a dietary supplement containing dried extracts of the main plants traditionally used for rheumatic disorders. The HPTLC method was chosen in order to circumvent the tedious and time-consuming sample preparation steps necessarily performed before using HPLC methods when analysing complex matrixes. Glucosamine was separated from the plant extracts on a silica gel 60 F(254) HPTLC plate using a saturated mixture of 2-propanol-ethyl acetate-ammonia solution (8%) (10:10:10, v/v/v). The plates were developed vertically up to a distance of 80 mm. For visualization, the plate was dipped into a ...

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The present work describes a simple, precise and accurate HPLC method for estimation of darifenacin hydrobomide in bulk and in tablet dosage form. The separation was achieved by using Waters Sunfire C 18 (4.6 X 250 mm) 5µm particle size column. The mobile phase consisted of 0.02M potassium dihydrogen phosphate buffer pH 7 adjusted with triethylamine: acetonitrile: methanol in the ratio of 40:30:30(v/v/v). Detection was carried out at 280 nm. The retention time of darifenacin hydrobromide was found to be 4.2 min respectively. The Limit of detection and limit of Quantification was found to be 2.112 µg/mL and 6.400 µg/mL respectively. The accuracy and reliability of the proposed method was ascertained by evaluating various validation parameters like linearity (10-100 µg/mL), precision, accuracy and specificity according to ICH guidelines. The proposed method provides an accurate and precise quality control tool for routine analysis of darifenacin hydrobromide in bulk and in tablet dosage form.

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