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CAS number: 115-86-6. NIOSH REL: 3 mg/m3 TWA. Current OSHA PEL: 3 mg/m3 TWA. 1989 OSHA PEL: Same as current PEL. 1993-1994 ACGIH TLV: 3 mg/m3 TWA. Description of substance: Colorless, crystalline powder with a phenol-like odor.. LEL :. . Unknown. Original (SCP) IDLH*: No Evidence [*Note: "Effective" IDLH = 1,500 mg/m3 - see discussion below.]. Basis for original (SCP) IDLH: The available toxicological data contain no evidence of an IDLH for triphenyl phosphate. AIHA [1970] reported that concentrations of triphenyl phosphate aerosol high enough to produce acute toxic effects in man have not been achieved. For this draft technical standard, therefore, respirators have been selected on the basis of the assigned protection factor afforded by each device. However, for some particulate substances for which no evidence of an IDLH exists, the determination of allowable respiratory protection based on protection factors may result in the assignment of respirators for concentrations that are not likely to ...
The report generally describes triphenyl phosphate, examines its uses, production methods, patents. TRIPHENYL PHOSPHATE market situation is overviewed;
GSK1349572 is an integrase inhibitor being developed for the treatment of human immunodeficiency virus (HIV)-1 infection by GlaxoSmithKline (GSK) on behalf of Shionogi-ViiV HealthcareLLC. In HIV-infected patients where combination antiretroviral therapy is the standard of care, it is likely that it will be dosed with boosted protease inhibitors (PIs) including fosamprenavir/ritonavir (FPV/RTV or FPV/r). As FPV and RTV are modulators (induction as well as inhibition) of Uridine diphosphate glucuronosyltransferase (UGT) and Cytochrome P450 (CYP)3A which are the primary and secondary metabolic pathways of GKS1349572, it is likely that FPV/RTV will affect the pharmacokinetics (PK) of GSK1349572, therefore a drug interaction study is warranted and will be evaluated in Part A of this study. Part B will evaluate the effect of particle size of tablet variants on the PK of GSK1349572.. In Part A, approximately 12 subjects will receive GSK1349572 50mg every 24 hours (q24h) for 5 days (Treatment A). ...
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Silver;diphenyl phosphate | C12H10AgO4P | CID 89672 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
The report focuses on North America major leading industry players providing information such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information. Upstream raw materials and equipment and downstream demand analysis is also carried out. The Cresyl Diphenyl Phosphate(CDP) industry development trends and marketing channels are analyzed. Finally the feasibility of new investment projects are assessed and overall research conclusions offered ...
Abstract : Triphenyl phosphate (TPP) is a triester of phosphoric acid and phenol. It is commonly used as a fire-retardingagent and plasticizer for nitrocellulose and cellulose acetate. The present study was an attempt to evaluate the impact ofbiofield treatment on physicochemical and spectroscopic properties of TPP. The study was carried out in two groups i.e.control and treatment. The treatment group was subjected to Mr. Trivedis biofield treatment. The control and treated samplesof TPP were characterized using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis(TGA), Fourier transform infrared (FT-IR), and ultraviolet-visible (UV-Vis) spectroscopy. XRD study revealed the decrease incrystallite size (6.13%) of treated TPP that might be due to presence of strains and increase in atomic displacement from theirideal lattice positions as compared to control sample. DSC thermogram of treated TPP showed the increase in meltingtemperature (1.5%) and latent ...
Scientists conducted a study with a group of 24 women. 6 hours after painting their nails, most of the participants were displaying elevated levels of diphenyl phosphate - a derivative of triphenyl phosphate which is formed in the process of metabolism. 10 hours after the beginning of the experiment, the levels of diphenyl phosphate in the bodies of all participants rose to 7 times above the norm. These results are truly alarming.. ...
APV10017 was a pharmacokinetic study that evaluated the pharmacokinetics, safety and tolerability of fosamprenavir/ritonavir (FPV/RTV) at reduced doses over 14 days in HIV-infected subjects with mild to moderate hepatic impairment (HI). Based on these data, two new regimens have recently been approved by the EMEA and FDA in these patient groups; FPV 700mg BID/RTV 100mg QD for those with mild HI (Child-Pugh score 4-6) and FPV 450mg BID/RTV 100mg QD for those with moderate HI (Child Pugh score 7-9). The Committee for Medicinal Products for Human Use (CHMP) has requested longer-term safety data among this hepatically impaired HIV-infected population who have received the recently updated FPV/RTV dosing regimens.. An observational cohort study will be conducted using routinely collected data in three European HIV patient cohorts with a high proportion of hepatitis co-infected individuals. Patients who received FPV/RTV will be followed to address the following objectives.. Primary: To assess the ...
PathHunter® Receptor Tyrosine Kinase (RTK) Internalization Assays are nonimaging, non-antibody based chemiluminescent detection assays that provide a direct and quantitative measurement of internalized RTKs localized to early endosomes. Your PathHunter Receptor Tyrosine Kinase Internalization Cell Line, when used in conjunction with a PathHunter Detection Kit (DiscoveRx, Cat. #93-0001 Series), provides a cell-based functional assay for receptor tyrosine kinase internalization. ...
[150 Pages Report] Check for Discount on 2016 Fosamprenavir (CAS 226700-79-4) Industry Market Report report by Prof Research. The Global and Chinese Fosamprenavir Industry, 2011-2021 Market Research...
A delayed peripheral neuropathy of the dying back or peripheral axonopathy variety predominates. Between 10 and 40 days after exposure, abrupt onset of flaccid paralysis is noted. This may be followed by lower extremity spasticity with clonus, hyperreflexia, hypertonus, and a peculiar spastic gait. In severe cases the full extent of paralysis may not be reached until after 2 to 3 months. Recovery is variable. Mortality is usually low and approximately 5% of victims may remain paralyzed. TOCP produced toxic effects on both male and female REPRODUCTIVE SYSTEMS when Long-Evans rats were given doses of 0 to 400 mg/kg by gavage prior to, and during breeding. Spermatotoxic effects, includes reduced motility, concentration, velocity, and abnormal morphology. Damage to ovarian and uterine tissue also 1999 ...
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
These results are particularly troubling since children, ages one to five, are in important stages of development and likely more sensitive to environmental chemicals, particularly those that affect their metabolism and hormones. ...
Dose: Growth: 0, .04, 0.63, .1, .16, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40uMRepro: 0, 0.1, 0.16, 0.25, 0.4, 0.63, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM ...
Browse drugs and medications alphabetically. Includes fosamprenavir, Fosamprenavir, Fosamprenavir Calcium, Fosamprenavir Oral Suspension, Fosamprenavir Tablets
Cubist Pharmaceuticals, Inc. (NASDAQ: CBST) announced today the U.S. Food and Drug Administration (FDA) approved SIVEXTRO™ (tedizolid phosphate) for t
194798-83-9 - GHJWNRRCRIGGIO-UHFFFAOYSA-N - Fosfluconazole [INN:BAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Generic Name: Fosamprenavir calcium. Brand Name: Telzir. Manufacturer: GlaxoSmithKline Inc.. Indications: HIV infection. Submission Type: New. Project Status: Complete. Date Recommendation Issued: June 16, 2005. Recommendation Type: List in a similar manner to other drugs in class. ...
Find patient medical information for Fosamprenavir Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Exposure to organophosphates has acute effects on health, but evidence of chronic effects is unclear. Many people who have been occupationally exposed
DESCRIPTION (provided by applicant): This SBIR project is in response to the call for the development of rapid and portable diagnostic tools for chemical threat exposure, suitable for use by emergency care providers in order to guide medical countermeasures. The broad objective of this proposal is to develop an extremely sensitive and selective biosensor device capable of detecting and discriminating proteins in human serum samples taken from personnel that have been exposed to potentially harmful levels of organophosphate-based nerve gas. This represents a novel approach in biomarker analysis because exposure to each different organophosphate (OP) chemical nerve agent results in a distinct protein "fingerprint" structure that can be identified, distinguished from other agents, and quantified. Using novel sensor thin polymer film technology, reporter domains will be customized with specific protein-recognition molecules that detect the OP poisoned proteins. This will make it possible to develop ...
Organophosphates and carbamates are the most frequently used insecticides worldwide. These compounds cause 80% of the reported toxic exposures to insecticides.
Bouche, S. , Klauck, E. , Fischer, D. , Lucassen, M. , Jung, K. and Hengge-Aronis, R. (1998): Regulation of RssB-dependent proteolysis in Escherichia coli: a role for acetyl phosphate in a response regulator-controlled process , Molecular microbiology ...
Question 5: While the cadmium concentration in both the fuel dissolution liquor and the PUREX_raffinate is very low, the polymeric complex of ________ of diethyl phosphate is shown in the left image. ...
Physiological changes in pregnancy can affect drug disposition. Plasma concentrations of several PIs -- including lopinavir, atazanavir and saquinavir -- ...
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have had 4 mc in the past year so you think i would get used to it by now! had erpc on sept 4th and since then have been ok. physically and mentally
This research report provides a concise analysis of the various important aspects of the global butylated triphenyl phosphate market. It presents a detailed overview of the market dynamics and the extent to which they impact the growth. It offers insights into the statistics related to the market at both global and regional levels. It takes into account the current scenario and historic data to derive trends of the market in the forthcoming years. It extensively covers tools such as market attractiveness analysis and Porters five force analysis that are useful in gauging the competitive environment of the market. It also profiles prominent players in the global butylated triphenyl phosphate market along with their latest development, revenue generation, business strategies, market shares, and contact information ...
This study focuses on the production side and consumption side of Tert Butylated Triphenyl Phosphate, presents the global Tert Butylated Triphenyl Phosphate market size by manufacturers, regions, type and application, history breakdown data from 2013
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Calyculins, highly cytotoxic polyketides, originally isolated from the marine sponge Discodermia calyx by Fusetani and co-workers, belong to the lithistid sponges group. These molecules have become interesting targets for cell biologists and synthetic organic chemists. The serine/threonine protein phosphatases play an essential role in the cellular signalling, metabolism, and cell cycle control. Calyculins express potent protein phosphatase 1 and 2A inhibitory activity, and have therefore become valuable tools for cellular biologists studying intracellular processes and their control by reversible phosphorylation. Calyculins might also play an important role in the development of several diseases such as cancer, neurodegenerative diseases, and type 2-diabetes mellitus. The fascinating structures of calyculins have inspired various groups of synthetic organic chemists to develop total syntheses of the most abundant calyculins A and C. However, with fifteen chiral centres, a cyano-capped tetraene unit, a
Research Report on Global Tert Butylated Triphenyl Phosphate Market Professional Survey Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Looking for online definition of organophosphates in the Medical Dictionary? organophosphates explanation free. What is organophosphates? Meaning of organophosphates medical term. What does organophosphates mean?
63886-53-3 - XRESZUDRGQQLFF-UHFFFAOYSA-N - Phosphinic acid, diethyl-, anhydride with diethyl phosphate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Fosamprenavir BASE CAS 226700-79-4 [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]carbamic acidC-[(3S)-tetrahydro-3-furanyl] ester Additional Names: (3S)-tetrahydro-3-furyl [(aS)-a-[(1R)-1-hydroxy-2-(N1-isobutylsulfanilamido)ethyl]phenethyl]carbamate dihydrogen phosphate (ester) Manufacturers Codes: VX-175 Molecular Formula: C25H36N3O9PS Molecular Weight: 585.61 Percent Composition: C 51.27%, H 6.20%, N 7.18%, O 24.59%, P 5.29%, S 5.48% WO 9933815 PRODUCT PATENT Fosamprenavir Systematic (IUPAC) name {[(2R,3S)-1-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid Clinical data Trade names Lexiva AHFS/Drugs.com monograph…
Temperature is one of the most important parameters for the performance, safety, and aging of lithium-ion batteries and has been linked to all main barriers for widespread commercial success of electric vehicles.. The aim of this thesis is to highlight the importance of temperature effects, as well as to provide engineering tools to study these.. The mass transport phenomena of the electrolyte with LiPF6 in EC:DEC was fully characterized in between 10 and 40 °C and 0.5 and 1.5 M, and all mass transport properties were found to vary strongly with temperature.. A superconcentrated electrolyte with LiTFSI in ACN was also fully characterized at 25 °C, and was found to have very different properties and interactions compared to LiPF6 in EC:DEC.. The benefit of using the benchmarking method termed electrolyte masstransport resistivity (EMTR) compared to using only ionic conductivity was illustrated for several systems, including organic liquids, ionic liquids, solid polymers, gelled polymers, and ...
Generic Name: Tedizolid phosphate. Brand Name: Sivextro. Manufacturer: Cubist Pharmaceuticals Canada, Inc.. Indications: Acute bacterial skin and skin structure infections. Submission Type: Pre-NOC. Project Status: Withdrawn. ...
Organophosphates (OPs) are chemical substances originally produced by the reaction of alcohols and phosphoric acid. In the 1930s, organophosphates were used as insecticides, but the German military developed these substances as neurotoxins in World War II.
Easy to read patient leaflet for Lexiva (Fosamprenavir Oral Suspension). Includes indications, proper use, special instructions, precautions, and possible side effects.
At a time of growing debate over the safety and usefulness of flame retardants added to consumer products,1 new evidence is emerging about the breadth of human exposure to one of the most widely used of these compounds. Two new studies2,3 document the presence of the flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in dust from homes, offices, and automobiles. They also report some of the first data on urine levels of a metabolite of this flame retardant.. In recent years, animal studies have suggested that TDCPP is neurotoxic, an endocrine disruptor, and a reproductive toxicant.4,5,6 The National Research Council has reported TDCPP to be linked to cancer in rats,7 and the chemical is on Californias Proposition 65 list of substances known to cause cancer.8 However, its potential carcinogencity has not been classified by the Environmental Protection Agency (EPA), the International Agency for Research on Cancer, or the National Toxicology Program.. TDCPP has long been a major flame ...
Organophosphates, which are made from phosphoric or phosphonic acid, are found in many kinds of insecticides, from lawn chemicals to flea and tick treatments. - Wag!
The COT has convened a Working Group to produce a draft COT statement, assessing whether there are long-term adverse neurological or neuropsychological effects from low-level exposure to organophosphates, insufficient to cause overt toxicity.
Oncogenic kinase activity is a common feature of nearly all cancers and kinases are major targets for therapeutic intervention. Pim kinases are deregulated in hematopoietic cancers including Acute Myeloid Leukemia (AML), as well as prostate cancer. While cancer cells can become dependent on Pim activity to sustain proliferation, in normal adult tissues, Pim kinase activity appears to be dispensable. These features make Pim kinases an attractive target for cancer therapy, however, their physiological roles have not been fully characterized. Using the reverse in-gel kinase assay (RIKA), we identified a battery of novel Pim substrates that are involved in mRNA splicing regulation. We hypothesized that Pim family kinases regulate mRNA splicing through phosphorylation of splicing factors. Microarray analysis revealed more than 10,000 splicing changes in AML cells treated with the highly selective small molecule Pim kinase inhibitor AZD1208. Using RT-PCR analysis, multiple AZD1208-induced splicing ...