TY - JOUR. T1 - Valganciclovir for cytomegalovirus prevention in solid organ transplant patients. T2 - An evidence-based reassessment of safety and efficacy. AU - Kalil, Andre C.. AU - Freifeld, Alison G.. AU - Lyden, Elizabeth R.. AU - Stoner, Julie A.. PY - 2009/5/13. Y1 - 2009/5/13. N2 - Background: Several anti-viral drugs have demonstrated efficacy in preventing Cytomegalovirus (CMV) infections in solid organ transplant (SOT) patients. The recently approved valganciclovir is the most commonly used and most expensive drug for CMV prevention. The safety and efficacy data have been drawn from a single trial. We hypothesized that valganciclovir may not be as safe as nor more effective than other therapies for CMV prevention. Methods: All experimental and analytical studies that compared valganciclovir with other therapies for prevention of CMV infection after SOT were selected. Based on meta-analytic and multivariate regression methodologies we critically analyzed all available evidence. ...
TY - JOUR. T1 - Oral Vancomycin Monotherapy Versus Combination Therapy in Solid Organ Transplant Recipients With Uncomplicated Clostridium difficile Infection. T2 - A Retrospective Cohort Study. AU - Korayem, G. B.. AU - Eljaaly, K.. AU - Matthias, K. R.. AU - Zangeneh, T. T.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Introduction: Solid organ transplant (SOT) recipients are at high risk of Clostridium difficile infection (CDI) and CDI recurrence due to their suppressed immune systems and antibiotic exposure. A combination of metronidazole and oral vancomycin is often prescribed for SOT recipients with uncomplicated CDI despite any clinical practice guidelines supporting the need for combination therapy. This study aims to compare the CDI recurrence rates of metronidazole/vancomycin combination therapy to oral vancomycin monotherapy in SOT recipients after a first episode of uncomplicated CDI. Methods: A single-center retrospective cohort study evaluated SOT recipients diagnosed with uncomplicated CDI ...
TY - JOUR. T1 - A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States. T2 - A single-center study. AU - Majeed, Aneela. AU - Beatty, Norman. AU - Iftikhar, Ahmad. AU - Mushtaq, Adeela. AU - Fisher, Julia. AU - Gaynor, Pryce. AU - Kim, Jeeyong C.. AU - Marquez, Jose L.. AU - Mora, Francisco E.. AU - Georgescu, Anca. AU - Zangeneh, Tirdad T. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background: Nocardiosis is a life-threatening opportunistic infection. Solid organ transplant (SOT) recipients are at higher risk (incidence 0.04%-3.5%) of developing nocardiosis. Rate of nocardiosis in the Southwestern US may be high due to environmental factors. Methods: We performed a retrospective review study on 54 SOT patients diagnosed with Nocardia between 1997 and 2016 at our center. To explore the association of various risk factors with both the development of disseminated disease and mortality, a series of Fishers exact tests was used. Findings: ...
Rejection and infection are primary causes of morbidity and mortality in solid organ transplant recipients. Current clinical practice relies on immunosuppressive drug levels measured in plasma to reflect the peripheral immune response in solid organ transplant recipients. Direct measurement of the number and functions of the immune cells themselves using multi-parameter flow cytometry may enable individualized immunosuppression management for organ transplant recipients. Multi-parameter flow cytometry will be used to compare levels and functional capabilities of multiple lymphocyte subsets between cohorts of patients receiving depletion induction and those receiving a non-depletion regimen. The activation state, cytotoxic potential and the functional capabilities of these cells will be examined within patients over the first six months post transplant ...
New-onset diabetes mellitus after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT was investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n1 = 696). Positive results were tested in a first STCS replication sample (n2 = 489) and SNPs remaining significant after multiple test corrections were tested in a second SOT replication sample (n3 = 156). Associations with diabetic traits were further tested in several large general population-based samples (n > 480 000). Only SP110 rs2114592C>T remained associated with NODAT in the STCS replication sample. Carriers of rs2114592-TT had 9.9 times (95% confidence interval [CI]: 3.22-30.5, P = .00006) higher risk for NODAT in the ...
TY - JOUR. T1 - Emerging causes of morbidity and mortality in organ transplant patients. AU - Torbenson, Michael. PY - 2006/6/1. Y1 - 2006/6/1. N2 - PURPOSE OF REVIEW: As short-term allograft and patient survival has improved following solid organ transplantation, medium and long-term causes of morbidity and mortality have come to the forefront of patient care. RECENT FINDINGS: The metabolic syndrome has relatively recently been defined and is now being applied to studies of posttransplant morbidity and mortality. The metabolic syndrome, and its individual risk factors such as obesity and diabetes mellitus, are highly prevalent in all solid organ transplant populations and negatively impact allograft and patient survival. Even when the metabolic syndrome is not present prior to transplantation, weight gain and the metabolic syndrome can develop following transplantation with negative outcomes. A second growing concern following transplantation is the development of late malignancies. The ...
OBJECTIVE To review the pharmacology, adverse events, drug interactions, and use of the nonprescription analgesics in solid-organ transplant recipients. STUDY SELECTION AND DATA EXTRACTION Studies evaluating nonprescription analgesics in solid-organ transplantation were considered for evaluation. English-language studies were selected for inclusion. DATA SYNTHESIS Nonprescription analgesics (aspirin, choline salicylate, magnesium salicylate, sodium salicylate, ibuprofen, ketoprofen, naproxen sodium, and acetaminophen) are the most commonly purchased over-the-counter agents in the United States. These agents, although generally considered safe, have been associated with a number of toxicities. The salicylates and nonsteroidal anti-inflammatory drugs have been associated with gastrointestinal damage, hematologic changes, liver and kidney dysfunction, and breathing difficulties. Acetaminophen has been shown to induce hematologic changes and liver and renal dysfunction. CONCLUSION A closer look at the
In a study reported in JAMA Oncology, Acuna et al found a nearly threefold increased risk of cancer mortality in solid-organ transplant recipients compared with the general population in Ontario, Canada.. Study Details. The population-based cohort study included data from 11,061 patients who underwent solid- organ transplantation in Ontario between 1991 and 2010, including 6,516 kidney, 2,606 liver, 929 heart, and 705 lung transplantations, representing 85,557 person-years of follow-up through December 2011. Recipients had a median age of 49 years, and 64% were male.. Increased Risk. Of 3,068 deaths in the cohort, 603 (20%) were cancer-related. Cancer mortality was significantly higher in transplant recipients than in the general population (standardized mortality ratio [SMR] = 2.84, 95% confidence interval [CI] = 2.61-3.07). Risk remained higher (SMR = 1.93, 95% CI = 1.75-2.13) in analysis, excluding patients with pretransplantation cancers (n = 1,124). Increased risk was observed for all types ...
Strippoli GFM, Hodson EM, Jones CA, Craig JC. Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients. Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD005133. DOI: 10.1002/14651858.CD005133.pub2. ...
Owers DS, Webster AC, Strippoli GFM, Kable K, Hodson EM. Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD005133. DOI: 10.1002/14651858.CD005133.pub3. ...
Although the standardizations of surgical procedures and improvements in intensive care treatment, patient selection, tissue matching and organ preservation have advanced the success of SOTs, PTSS remain a frequent finding in post-SOT patients, and until now only few empirical data exist about the prevalence of PTSS among patients undergoing SOTs [30, 31]. PTSS after SOT can cause compliance problems and decreases long-term survival [32]. In our study 19 (15.1%) SOT recipients displayed PTSS. This rate is consistent with previous research. For example, in an orthotopic liver transplantation study by Rothenhäusler et al. [24], 2.7% suffered from full PTSD and 16% from partial PTSD 3.8 years after transplantation. In another study by Favaro et al. [33], the estimated frequency of transplantation-related PTSS after heart transplantation was 12%. PTSD in SOT recipients may indicate a failure of the patient to come to terms with the transplant experience and Dew et al. reported that the risk of ...
View my most recent publications at PubMed. Kotton CN, Kumar D, Caliendo AM, Asberg A, Chou S, Snydman DR, Allen U, Humar A, International Consensus Guidelines on the Management of Cytomegalovirus in Solid Organ Transplantation. Transplantation. 2010;89(7):779-95. Kotton CN, Lattes R, Parasitic infections in solid organ transplant recipients. Am J Transplant. 2009;9 Suppl 4:S234-51.. Kotton CN, Hibberd PL, Travel medicine and the solid organ transplant recipient. Am J Transplant. 2009;9 Suppl 4:S273-81. Kumar D, Morris MI, Kotton CN, Fischer SA, Michaels MG, Allen U, Blumberg EA, Green M, Humar A, Ison MG, Guidance on Novel Influenza A/H1N1 in Solid Organ Transplant Recipients. Am J Transplant. 2009. Kotton CN, Elias N, Delmonico FL, Kradin RL. Case records of the Massachusetts General Hospital. Case 15-2009. A 25-year-old man with coma after cardiac arrest. N Engl J Med. 2009;360(20):2118-25.. Marconi VC, Kradin R, Marty FM, Hospenthal DR, Kotton CN. Disseminated dermatophytosis in a patient ...
Content Update. May 26, 2020. Expanding the Donor Pool in Solid Organ Transplantation: The landscape of solid organ transplantation has changed based on organ allocation and a larger number of candidates on waiting lists. Transplant centers are expanding use of nontraditional donors to aid in access to transplantation. This changes the appropriate transplant immunosuppression and post-transplant monitoring and often dictates additional medication such as antivirals. Pharmacotherapy decisions are often complicated by prolonged organ dysfunction, specifically liver and kidney. This update focuses on four different scenarios and their implications, namely the use of donors who are: (1) older; (2) donate after cardiac death; (3) living, specifically for liver donation; and (4) Hepatitis C antibody positive.. ...
Human cytomegalovirus (HCMV) is a beta-herpesvirus able to establish a life-long persistent infection after primary infection has been cleared. Although infection is ubiquitous in the human population, persistent HCMV infection is commonly asymptomatic in healthy, immunocompetent individuals. However, HCMV causes significant disease in immunosuppressed patients and, despite effective antiviral therapies, HCMV infection is still a significant problem in congenital disease and in bone marrow transplant recipients. Additionally, HCMV has been associated with long-term diseases including the vascular diseases atherosclerosis, restenosis following angioplasty, and chronic allograft rejection following solid organ transplantation [1-4]. Recently, HCMV has been detected in human glioblastomas, and it has been suggested that HCMV exacterbates the progression of this disease [5]. Chemokines and their receptors have been identified as key mediators in chronic inflammatory processes that attend the ...
TY - JOUR. T1 - Pharmacokinetics of Basiliximab for the Prevention of Graft-versus-Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal-Intensity Cyclophosphamide and Fludarabine. AU - Podichetty, Jagdeep T.. AU - Brinda, Bryan J.. AU - Nelson, Robert P.. AU - Karr, Alissa H.. AU - Prasad, Nagendra K.. AU - Quinney, Sara. AU - Foxworthy Scott, Susanna. AU - Kiel, Patrick J.. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Study Objective: Basiliximab is an immunosuppressive monoclonal antibody used for rejection prevention following solid organ transplantation; the pharmacokinetics (PK) of basiliximab in this setting are known. Basiliximab may also be used for prophylaxis and treatment of graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic cell transplantation (HCT); however, the PK of basiliximab in this setting are not known. Clinical transplant providers expect variation in the volume of distribution and clearance after nonmyeloablative ...
BACKGROUND: Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate Gene studies (SNP group#3) influence BMI in SOT populations and if they predict ≥10% weight gain (WG) one year after transplantation. To do so, two samples (nA = 995, nB = 156) were obtained from naturalistic studies and three w-GRS were constructed and tested for association with BMI over time. Prediction of 10% WG at one year after transplantation was assessed with models containing genetic and clinical factors ...
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Congenital or acquired states of immunosuppression, which include solid organ transplants (SOTs), are a well-known predisposing factor for cancer development in childhood. The preparative regiments for SOT, as well as anti-rejection prophylaxis and treatment, impair the immune response and limit the immune systems capacity to recognise and eliminate cancer cells and to suppress the activity of oncogenic viruses. The 20-year cumulative cancer risk of SOT recipients is estimated at more than 50%, 5-10 times that of the general population, and is one of the leading causes of mortality in this group.1. As is the case in other situations in paediatric oncology, age is a determinant that leads to scenarios differing from those in the adult population. The probability of developing cancer in individuals aged less than 25 years is up to 50 times higher. The carcinogenic risk of immunosuppression is compounded by additional risks associated with exposure to various agents and by lifestyle factors in ...
The health of all populations will benefit from a comprehensive response to diseases contributing to end-stage organ failure, from prevention to access to effective organ transplantation programmes made possible by a sufficient supply of donor organs. There is also a strong economic imperative to improve rates of transplantation and therefore organ donation: kidney transplantation is less costly to provide than dialysis, and therefore, maximizing rates of kidney transplantation would significantly reduce overall expenditure on renal replacement therapies. Kidney transplantation also results in better survival and quality of life outcomes and enables greater productivity and community participation. The perception of organ transplantation as an expensive and luxury clinical practice is invalid; rather it is cost effective, mainstream, and a cardinal feature of comprehensive health services. Beyond the unmistakable medical benefits to patients affected by end-stage organ failure, organ ...
Organ transplantation has developed at an incredibly rapid pace since its introduction in the 1950s, and it has become a life-saving procedure for patients with end-stage organ failure. In 2009, more than 20,000 hematopoietic stem cell transplantations and 27,000 solid organ transplantations were performed in the United States alone.
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Outcomes after solid organ transplantation continue to improve, but premature loss of life remains a major concern, with death from cerebrovascular disease and cardiovascular disease accounting for around 20% late deaths. There are multiple contributory factors including preexisting, and the posttransplant development of, cardiometabolic conditions (such as hypertension, diabetes mellitus, hyperlipidemia, and obesity). There is accumulating evidence that the regular engagement in exercise is an important factor affecting outcomes before, during, and after transplantation; yet most waitlist candidates and recipients have reduced levels of physical activity. The mechanisms whereby physical activity is associated with better outcomes and a reduction in risk factors for cardiovascular disease are incompletely understood. Attempts to increase physical activity in the transplant population, as in the general population, have had limited success. Use of concepts from Nudge theory provides an ...
Infection is the leading cause of morbidity and mortality in immunocompromised patients such as hematopoietic/solid organ transplant recipients and individuals with human immunodeficiency virus. Community respiratory virus infections are increasingly recognized as a significant threat to these patie …
TY - JOUR. T1 - Deciphering the role of eosinophils in solid organ transplantation. AU - Onyema, Oscar Okwudiri. AU - Guo, Yizhan. AU - Hata, Atsushi. AU - Kreisel, Daniel. AU - Gelman, Andrew E.. AU - Jacobsen, Elizabeth A.. AU - Krupnick, Alexander Sasha. PY - 2020/4/1. Y1 - 2020/4/1. N2 - Eosinophils are rare granulocytes that belong to the innate arm of the immune system. This cell population is traditionally defined as a destructive and cytotoxic mediator in asthma and helminth infection. Limited data in transplantation have suggested that eosinophils play a similar role in potentiating deleterious organ inflammation and immunologic rejection. Contrary to this long-held notion, recent data have uncovered the possibility that eosinophils play an alternative role in immune homeostasis, defense against a wide range of pathogens, as well as downregulation of deleterious inflammation. Specifically, translational data from small animal models of lung transplantation have demonstrated a critical ...
TY - JOUR. T1 - Transmission of hepatitis C virus with solid organ transplantation. T2 - Incidence and clinical significance. AU - Roth, D.. AU - Fernandez, J. A.. AU - Babischkin, S.. AU - DeMattos, Angelo M. AU - Buck, B. E.. AU - Quan, S.. AU - Olson, L.. AU - Burke, G. W.. AU - Nery, J. R.. AU - Esquenazi, V.. AU - Schiff, E. R.. AU - Miller, J.. PY - 1993. Y1 - 1993. UR - http://www.scopus.com/inward/record.url?scp=0027502448&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027502448&partnerID=8YFLogxK. M3 - Article. C2 - 7680166. AN - SCOPUS:0027502448. VL - 25. SP - 1476. EP - 1477. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 1 SUPPL. 1. ER - ...
Cytomegalovirus prophylaxis with antiviral agents for solid organ transplantation answers are found in the Evidence-Based Medicine Guidelines powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
TY - JOUR. T1 - Regenerative medicine as applied to solid organ transplantation. T2 - Current status and future challenges. AU - Orlando, Giuseppe. AU - Baptista, Pedro. AU - Birchall, Martin. AU - De Coppi, Paolo. AU - Farney, Alan. AU - Guimaraes-Souza, Nadia K.. AU - Opara, Emmanuel. AU - Rogers, Jeffrey. AU - Seliktar, Dror. AU - Shapira-Schweitzer, Keren. AU - Stratta, Robert J.. AU - Atala, Anthony. AU - Wood, Kathryn J.. AU - Soker, Shay. PY - 2011/3. Y1 - 2011/3. N2 - In the last two decades, regenerative medicine has shown the potential for "bench-to-bedside" translational research in specific clinical settings. Progress made in cell and stem cell biology, material sciences and tissue engineering enabled researchers to develop cutting-edge technology which has lead to the creation of nonmodular tissue constructs such as skin, bladders, vessels and upper airways. In all cases, autologous cells were seeded on either artificial or natural supporting scaffolds. However, such constructs were ...
The advancing science of transplantation has led to more transplants and longer survival. As a result, primary care physicians are more involved in the care of transplant recipients. Immunosuppressive therapy has significantly decreased rates of transplant rejection but accounts for more than 50% of transplant-related deaths, often due to infections and other risks related to long-term use. Cardiovascular disease is the leading cause of non-transplant-related mortality. Aggressive risk factor management is recommended for transplant recipients, including a blood pressure goal of less than 130/80 mm Hg and statin therapy in kidney, liver, and heart recipients. Fertility typically increases posttransplant, and female transplant recipients should avoid pregnancy for one year after surgery. The best contraceptive choice is usually an intrauterine device. Because of the increased risk of infection, patients should be tested for graft dysfunction or infection if suspicion arises. Testing should be coordinated
Organ transplantation is one of the best therapeutic options for patients with end-stage organ failure. Experimental organ transplantation is an important link between basic science and clinical practice. Both editors, Dr. Chen and Dr. Qian, have been working in this area for more than 20 years. Experts from the United States, Canada, China, Japan, Italy, Spain, Turkey, Switzerland, Hungary, and Brazil contributed 25 chapters in this book, and provided detailed descriptions of techniques for vascularized organ allografts in mice, rats, pigs, and nonhuman primates, as well as detailed descriptions of non-vascularized pancreatic islet and spleen allografts.. Furthermore, they discussed new advances in transplantation immunology. This book provides numerous important references which were carefully selected by the authors to extend their visions and knowledge. The appropriate readers of this book include medical students, graduate students, residents, surgeons, physicians and immunologists ...
Vaccine preventable infections are a recognized and potentially serious complication following solid organ transplant. Compared to healthy children, infections in organ transplant recipients are more likely to be complicated and even life threatening. However, the true incidence, morbidity, mortality, and costs resulting from hospitalizations for vaccine preventable illnesses in the pediatric liver transplant population remain unknown. The objectives of this study were to examine in liver transplant recipients at centers participating in the Pediatric Health Information System (PHIS) dataset ...
The American Society of Transplantation is dedicated to advancing the field of transplantation and improving patient care by promoting research, education, advocacy, organ donation, and service to the community.. ...
AFP February 1, 2016 - 50% of transplant-related deaths are due to immunosuppressive drugs, mostly infections - Most immunosuppressive drugs are metabolized via cytochrome P450 3A4 - so lots of interactions - Transplant recipients have increased risk of CAD and cardiovascular death HTN - goal (expert recommendation) is less than 130/80 mmHg - CCB reduce…
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
Describe clinical and epidemiological differences and risk factors for death among Bloodstream Infections (BSI) caused by Gram Negative (GN) and Gram Positive (GP) bacteria in the setting of solid organ transplantation. We performed a retrospective analysis of medical records, which were evaluated patients undergoing solid organ transplantation with BSI in the period from January 2000 to January 31, 2006 at Hospital São Paulo and Hospital do Rim e Hipertensão (Universidade Federal de São Paulo, Brazil). It was also performed the analysis of risk factors for death. 195 patients were included in this study with a mean age of 43.3 (± 0.90) years, 114 (58.5 %) were male and, 81 (41.5 %) were female. 168 (86.2 %) were kidney transplants, 16 (8.2 %) kidney-pancreas, 5 (2.6 %) heart, 5 (2.6 %) liver and 1 (0.5 %) liver-kidney. The mean hospital stay was 34.2 (± 62.7) days. GN accounted for 147 (75.4 %) of the BSI episodes, whereas 48 (24.6 %) were caused by GP. In the group with BSI by GN the most common
There is increasing literature on immunologic monitoring for cytomegalovirus (CMV) post-transplant in order to guide antiviral therapy. Assays used for immune monitoring include the Quantiferon-CMV, ELISpot, and flow cytometry-based quantitation of CMV-specific T-cells. In this study, 134 SOT patients had immunologic monitoring by flow cytometry as well as CMV viral loads. At 1 year after transplant, the majority of patients (89%) had CMV-specific immunity. The presence of both CD4+ and CD8+ T cell immunity correlated with the ability to control CMV viremia. This study shows the importance of measurement of CMV-specific immunity although much work needs to be done to standardize immune function assays before they can be used clinically.. ...
TY - JOUR. T1 - Cyclosporine induces cancer progression by a cell-autonomous mechanism. AU - Hojo, Minoru. AU - Morimoto, Takashi. AU - Maluccio, Mary. AU - Asano, Tomohiko. AU - Morimoto, Kengo. AU - Lagman, Milagros. AU - Shimbo, Toshikazu. AU - Suthanthiran, Manikkam. PY - 1999/2/11. Y1 - 1999/2/11. N2 - Malignancy is a common and dreaded complication following organ transplantation. The high incidence of neoplasm and its aggressive progression, which are associated with immunosuppressive therapy, are thought to be due to the resulting impairment of the organ recipients immune- surveillance system. Here we report a mechanism for the heightened malignancy that is independent of host immunity. We show that cyclosporine (cyclosporin A), an immunosuppressant that has had a major impact on improving patient outcome following organ transplantation, induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Our studies show that cyclosporine ...
The Division of Transplantation (DoT) is within the Department of Health and Human Services, Health Resources and Services Administrations Healthcare Systems Bureau (HSB). DoT is the primary federal entity responsible for oversight of the organ and blood stem cell transplant systems in the U.S. and for initiatives to increase the level of organ donation in this country. HSBs Organ Donation and Transplantation programs extend and enhance the lives of individuals with end-stage organ failure for whom an organ transplant is the most appropriate therapeutic treatment. Key elements of the program include the Organ Procurement and Transplantation Network (OPTN), the national system that allocates and distributes donor organs to individuals waiting for an organ transplant; the Scientific Registry of Transplant Recipients (SRTR), a national database of statistics related to solid organ transplantation -- kidney, liver, pancreas, intestine, heart, and lung; and efforts to increase the supply of donor ...
Raltegravir (RAL) is a preferred option for initial antiretroviral therapy in the most recent HIV Treatment Guidelines and is emerging as a popular choice for use in the specialized population of HIV-infected patients being considered for solid organ transplantation. Data from HIV-infected persons with normal organ function have revealed few raltegravir-associated metabolic complications compared to older antiretrovirals, and in general, drug-drug interactions with raltegravir are infrequent. The absence of such concerns appears to make raltegravir a potentially appealing option for antiretroviral therapy in HIV-infected patients being considered for solid organ transplantation.. At present, however, little is known of the safety and long term tolerability of RAL-containing regimens in persons undergoing solid organ transplantation. As more HIV-infected patients undergo organ transplantation, there is a growing need for good data on such things as the effect of dialysis on RAL concentrations, ...
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... can be a influential method for the treatment of end-stage organ failure. Transplantation is the process of transferring cells, tissues, or organs from one site to another. The dysfunction of an organ system can be reformed with transplantation of an organ from a donor. However, the immune system remains the most dreadful barrier to transplantation as a routine medical treatment. The immune system has developed complex and effective mechanisms to conflict foreign agents. These mechanisms are also involved in the dismissal of transplanted organs, which are perceived as foreign by the recipients immune system.. Transplantation can be a influential method for the treatment of end-stage organ failure. Transplantation is the process of transferring cells, tissues, or organs from one site to another. The dysfunction of an organ system can be reformed with transplantation of an organ from a donor. However, the immune system remains the most dreadful barrier to transplantation as a ...
Organ transplant patients usually spend a lifetime on expensive and often dangerous anti-rejection drugs. But experts have announced that such drugs may not even be needed in the future, thanks to a new study that suggests patients receiving an organ that is less than a perfect match can be protected against rejection by a second transplant of the donor´s imperfectly matched stem cells. The study is being hailed as a game-changer for transplantation.. Experts announced the success of kidney transplants for a small number of patients, using a relatively new technique known as normothermic perfusion. This involves the warming of the kidney with oxygenated blood after it has been in cold storage. This technique also boosts the function of damaged kidneys from "marginal donors," such as the elderly or those with high blood pressure and diabetes, and also reduces the risk of the organ being rejected.. Also, an injection of stem cells given with the kidney transplant could remove the need for ...
HIV Solid Organ Transplant Candidate/Recipient answers are found in the Johns Hopkins HIV Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
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Officials with the Department of Motor Vehicles teamed up with organ transplant recipients to encourage people to volunteer to become organ donors - when getting their drivers licenses.
Data analysis has shown that transplant recipients are twice as likely to develop melanoma than people who have not undergone a transplant.
In patients with schizophrenia, consent postmortem for organ donation for transplantation and research is usually obtained from relatives. By means of a questionnaire, the authors investigate whether patients with schizophrenia would agree to family members making such decisions for them as well as compare decisions regarding postmortem organ transplantation and brain donation between patients and significant family members. Study results indicate while most patients would not agree to transplantation or brain donation for research, a proportion would agree. Among patients who declined organ donation for transplantation or brain research, almost half of family members would have agreed to brain donation for research and over 40% to organ transplantation. Male relatives are more likely to agree to organ donation from their deceased relatives for both transplantation and research. The authors argue that it is important to respect autonomy and interests of research subjects even if mentally ill and ...
Washington, DC (August 1, 2011) - U.S. Senators Dick Durbin (D-IL), Thad Cochran (R-MS), and Scott Brown (R-MA) today introduced bipartisan legislation to improve the quality of life for people with kidney disease. The Comprehensive Immunosuppressive Drug Coverage for Kidney Transplant Patients Act would assist thousands of Americans under the age of 65 who are being cut off from Medicare after 36 months by extending coverage of immunosuppressive drugs for kidney transplant recipients. Also cosponsoring todays legislation were U.S.
Organ transplantation remains to be a treatment of choice for patients suffering from irreversible organ failure. Immunosuppressive (IS) drugs employed to maintain the allograft have shown excellent...
Organ transplantation is accompanied by nonspecific immune suppression...It was known that anergic T cells (immune T cells that do not respond ...The authors stimulate recipient T cells from the monkeys with donor ce...Title: Renal allograft rejection is prevented by adoptive transfer of ...,Monkeying,around,to,improve,organ,transplantation,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
TY - JOUR. T1 - Personalized peptide arrays for detection of HLA alloantibodies in organ transplantation. AU - Liu, Pan. AU - Souma, Tomokazu. AU - Wei, Andrew Zu Sern. AU - Xie, Xueying. AU - Luo, Xunrong. AU - Jin, Jing. PY - 2017/9/6. Y1 - 2017/9/6. N2 - In organ transplantation, the function and longevity of the graft critically rely on the success of controlling immunological rejection reactivity against human leukocyte antigens (HLA). Histocompatibility guidelines are based on laboratory tests of anti-HLA immunity, which presents either as pre-existing or de novo generated HLA antibodies that constitute a major transplantation barrier. Current tests are built on a single-antigen beads (SAB) platform using a fixed set of ~100 preselected recombinant HLA antigens to probe transplant sera. However, in humans there exist a far greater variety of HLA types, with no two individuals other than identical twins who can share the same combination of HLA sequences. While advanced technologies for HLA ...