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Sigma-Aldrich offers abstracts and full-text articles by [J M Müller, U Isele, E Metzger, A Rempel, M Moser, A Pscherer, T Breyer, C Holubarsch, R Buettner, R Schüle].
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BACKGROUND: The combination of complete genome sequence information with expression data enables us to characterize the relationship between a proteins evolutionary origin or functional category and its expression pattern. In this study, mouse proteins were assigned into functional and phyletic groups and the gene expression patterns of the different protein groupings were examined by microarray analysis in various mouse tissues. RESULTS: Our results suggest that the proteins that are universally distributed in all tissues are predominantly enzymes and transporters. In contrast, the tissue-specific set is dominated by regulatory proteins (signal transduction and transcription factors). An increased tendency to tissue-specificity is observed for metazoan-specific proteins. As the composition of the phyletic groups highly correlates with that of the functional groups, the data were tested in order to determine which of the two factors - function or phyletic age - is dominant in shaping the ...
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Cell Biologics provides custom services to our customers upon request. On request, we will isolate cells of any description from specific organs or tissues (any animal or human tissues) designated by our customers. Customer may ship to Cell Biologics either the already excised tissues or live mice or rats, and we will isolate the desired cell type and return a vial to Customer containing the prepared cells ready to use. If you have any special needs in isolation of endothelial cells, epithelial cells, macrophages, bone marrow derived cells or other cell types from animal or human tissues, please contact us for this special service. Let us know what you need and we will accommodate you. For details regarding these special services contact us at [email protected] We will contact you promptly within1 day. ...
Korang pernah tak mengalami bengkak pada mata yang terjadi dengan sendirinya? Entah dari mana tah dia datang. Tiba tiba je da muncul dekat kelopak mata. Pernah tak. Pernah tak? Orang biasa paggil ketumbit ke ketumbr tah. Aku pun tak sure. Ala, yang kalau orang nampak mata kita bengkak, orang akan selalu cakap: " Haa. Tula, gi ngitai orang mandi la tu." Ntah pape je kan alasan tuh. ...
Of the many plant genes whose expressions are controlled by the circadian clock, one of the phosphoenolpyruvate carboxylase kinase genes in soya bean (Glycine max) exhibits the unusual property that its control is organ-specific - it is under circadian control in leaves but not in roots. Preliminary experiments suggest that the same is true for at least one gene in Arabidopsis thaliana. It will be important to define the extent and function of this phenomenon and the underlying mechanism.. ...
It has been assumed that exosomes are cellular trash bags for elimination of excess proteins, but many studies have shown that exosomes often exhibit certain specific markers, irrespective of the organ or cellular source. This suggests that certain proteins are transported to the exosomes with some degree of specificity. Additionally, distinct differences have been identified in the RNA and protein species present in exosomes, likely reflecting cellular and organ specificity. This second layer of complexity is dynamic and can change with the evolving status of the organ and cells within. Here, the pancreas is provided as an example, but this dynamism in exosomal contents presumably holds true for all organs. Therefore, exosome heterogeneity is a much more complex phenomenon than cellular heterogeneity and can be fleeting depending on stimuli and the functional status of the organ ...
TY - JOUR. T1 - A csontáttétképzodés molekuláris alapjai és célzott terápiája. AU - Tímár, J.. PY - 2010/3/1. Y1 - 2010/3/1. N2 - Formation of bone metastasis is a hallmark of the progression of several solid cancers, providing example for the organ specificity of the process. Bone metastasis may result in both venous and arterial dissemination. Though the molecular basis of the lytic and plastic bone metastasis formation is different, in reality these organ metastases represent a mixture of the two processes. The basis of bone metastasis formation is the activation of osteoclasts and the resulting bone resorption, initiating a vicious circle by activating the initiator cancer cell. The discovery of osteoclast-bone matrix interaction inhibitor bisphosphonates revolutionized the therapy of bone metastasis. Clarifying the molecular pathways involved in bone metastasis formation identified osteoclast differentiation as another feasible target. This process is under control of the TNF ...
TY - JOUR. T1 - Cloning of a novel amphiphysin isoform edna composed of multiple splicing variants and their differential tissue expression. AU - Tsutsui, Kimiko. AU - Maeda, Yukihide. AU - Tsutsui, Ken. AU - Sa, Kuniaki. AU - Seki, Shuji. AU - Tokunaga, Akira. PY - 1997/12/1. Y1 - 1997/12/1. N2 - Amphiphysin, an Stt3-domain containing protein concentrated in nerve terminals, is believed to be involved in the synaptic vesicle recycling. We have cloned cDNAs of a novel isoform of amphiphysin from mammals (man, rat, and mouse) by utilizing sequence information for homologous ESTs accumulated in databases. More than 10 subtypes of the isoform with 50-60 amino acid identity to the human amphiphysin were identified by a conventional library screening and PCR amplification of cDNA libraries. Each subtype probably represents a splicing variant of a single gene transcript. Analysis of mRNA expression in various tissues by RT-PCR showed that the isoform is more ubiquitously distributed than the canonical ...
ON THIS PAGE: You will find a list of common tests, procedures, and scans that doctors use to find the cause of a medical problem. Use the menu to see other pages.Doctors use many tests to find, or diagnose, cancer. They also do tests to learn if cancer has spread to another part of the body from where it started. If this happens, it is called metastasis. For example, imaging
I have to isolate total RNA/polyA+ RNA from various human tissues, healthy and diseased. In order to estimate the amount of starting material in grams, I need to know what RNA yield to expect from that tissue and how many grams of that particular tissue one can get from one donor. I was wondering if there are any reliable resources on : A) how much total RNA/polyA+ RNA one can get per gram of various human tissues B) how many grams of various tissues (anything imaginable, including weight of left and right ventricle, atria, septal wall, various brain regions, DRG, aorta, tongue, prostate etc. etc.) does an average human body have. Many thanks, B ...
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Gluecksohn, waelsch S. and Rota, T R., "Development in organ tissue culture of kidney rudiments from mutant mouse embryos." (1963). Subject Strain Bibliography 1963. 428 ...
Following the irreversible loss of function of the brain (brain death), the different organs and tissues will give up their function one after another. Due to the fact that organs retain certain amounts of energy sources they can maintain their function or the function of individual cells for some time, even after brain death. Those supravital functions include (electrically stimulated) muscle contraction as much as 20 hours after death. The time until the last cell dies depends on the specific organ. ...
Cell Biologics provides custom cell isolation service upon request. On request, we will isolate cells of any description from specific organs or tissues (any animal or human tissues) designated by our customers. If you would like to use of Custom Cell Isolation Service, for details regarding these special services, please contact us at [email protected] Thank You!. ...
Video created by 杜克大学 for the course 人体生理学导论. Welcome back! In this module we consider how the circulatory system works to deliver oxygen and nutrients to the specific organs. We start with a discussion of the electrical and mechanical ...
Video created by Universidad Duke for the course Introductory Human Physiology. Welcome back! In this module we consider how the circulatory system works to deliver oxygen and nutrients to the specific organs. We start with a discussion of the ...
41. While cost blтod have played a role in slowing the activation gviing programs (costs are in the range giving blood propecia 60,000 to 250,000, depending on the specific organ), these figures do not accurately reflect the cost of this procedure to society. 72, 276в282.
Ethris proprietary Stabilized Non-Immunogenic mRNA (SNIM® RNA) platform includes a toolbox of technologies to generate mRNA molecules that are stable, result in production in the patients own body of therapeutic proteins, and which escape recognition by the bodys immune system. These mRNA technologies paired with Ethris proprietary delivery systems for organ- and cell- targeted delivery of mRNA has generated a pipeline of Transcript Therapies, which Ethris is developing to treat serious diseases ...
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We all know that our body is made up of thousands of organs and all these organ combine together to form into various organ systems. All these organ s
Although alopecia areata (AA) is one of the most frequent organ-specific autoimmune diseases, the association of AA with other autoimmune diseases and the genetic basis of the association remain to be analyzed. Among the autoimmune diseases associated with AA, autoimmune thyroid disease was most frequent (10.0%), followed by vitiligo (2.7%) and rheumatoid arthritis (0.9%) but not type 1 diabetes (0.0%). The prevalence of thyroid-related autoantibodies in patients with AA was significantly higher than that in controls (TSH receptor antibody [TRAb]: 42.7% vs 1.2%, P = 1.6 × 10(-46); thyroid peroxidase antibody: 29.1% vs 11.6%; P = 1.7 × 10(-6)), whereas the prevalence of islet-related autontibodies was comparable between patients with AA and control subjects. The frequency of DRB1*15:01-DQB1*06:02, a protective haplotype for type 1 diabetes, was significantly higher in TRAb-positive (12.8%, P = .0028, corrected P value [Pc] = .02) but not TRAb-negative (7.1%, not significant) patients with AA ...
Authors: Xue-Ru Wu, MD, professor, Urology and Pathology; Joseph B. Guttenplan, PhD, research associate professor, Environmental Medicine and Basic Science. Butyl-hydroxybutyl-N-nitrosamine (BBN) is a powerful carcinogen that specifically causes bladder cancer in rodents, the reason for such a high degree of organ specificity is unclear. BBN is a primary metabolite of the environmental carcinogen, dibutylnitrosamine and hence a potential human carcinogen. Mutagenesis induced by BBN in a chromosomally incorporated mutagenesis reporter gene was measured in bladder urothelial cells and smooth muscle cells of mice or rats and compared with mutagenesis in liver, kidney, ureter and forestomach. Since mutagenesis in the reporter gene is a surrogate for mutagenesis in general, researchers hypothesized mutations also induced in critical growth control genes would contribute to the tumor formation induced by BBN. Researchers found mutagenesis correlated with the organ specificity for cancer induction by ...
Understanding how genes are expressed and regulated in different tissues is a fundamental and challenging question. However, most of currently available biological databases do not focus on tissue-specific gene regulation. The recent development of computational methods for tissue-specific combinational gene regulation, based on transcription factor binding sites, enables us to perform a large-scale analysis of tissue-specific gene regulation in human tissues. The results are stored in a web database called TiGER (Tissue-specific Gene Expression and Regulation). The database contains three types of data including tissue-specific gene expression profiles, combinatorial gene regulations, and cis-regulatory module (CRM) detections. At present the database contains expression profiles for 19,526 UniGene genes, combinatorial regulations for 7,341 transcription factor pairs and 6,232 putative CRMs for 2,130 RefSeq genes. We have developed and made publicly available a database, TiGER, which summarizes and
miRNA is a set of small, non-coding RNA molecules that regulate gene expression post transcription. These molecules have an impact on a wide range of biological functions such as cell cycle control, stem cell differentiation, immune modulation, viral replication, and metabolic control. As the aforementioned processes are involved in the pathology of various diseases, tests performed on miRNAs help in disease treatment. Moreover, miRNAs can be easily manipulated than proteins, thus making them more useful for clinical diagnostics and therapeutics applications. The global miRNA tools and services market was valued at $146 million in 2015 and is expected to reach $620 million by 2022, growing at a CAGR of 23.4% during the forecast period. It is expected to witness significant growth owing to the rise in incidence of cancer, auto-immune, and cardiovascular diseases. In addition, miRNA molecules possess specific properties, such as higher tissue and organ specificity; and ability to cross the ...
Lee, J. C., Zhao, J. T., Clifton-Bligh, R. J., Gill, A., Gundara, J. S., Ip, J. C., Glover, A., Sywak, M. S., Delbridge, L. W., Robinson, B. G. and Sidhu, S. B. (2013), MicroRNA-222 and MicroRNA-146b are tissue and circulating biomarkers of recurrent papillary thyroid cancer. Cancer, 119: 4358-4365. doi: 10.1002/cncr.28254 ...
Understanding regulation of developmental events has increasingly required the use of tissue-specific expression of diverse factors affecting plant growth and environmental responses. To allow for cloning of presumptive promoters with tissue-specific activities, we created two plant expression vectors with multiple cloning sites upstream of a Gateway cassette for expression of either untagged or YFP-tagged genes of interest (Michniewicz et al., 2015) by modifying the pEarleyGate100 and pEarleyGate104 constructs (Earley et al., 2006). For fast and easy tissue-specific expression of desired genes, we further developed a set of Gateway-compatible tissue-specific gene expression vectors that allow for the expression of YFP-tagged or untagged proteins driven by various promoters (see table below). Additional vectors will be added to this table as they are created. These vectors provide an invaluable resource to the plant community, allowing for rapid generation of a variety of tissue-specific ...
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Background Variation in gene expression is extensive among tissues, individuals, strains, populations and species. The interactions among these sources of variation are relevant for physiological...
Brains that go bump in the night. Brain science has come a long way in the last 200 years. We look back at the early efforts of the phrenologists to map personality, behaviour and mental abilities onto specific organs of the brain with amusement. But that is only because their methodology was so woefully inadequate. These…
Viral surface protein implicated in the binding to specific host surface molecule(s). This binding can lead to virion entry into the host cell, it can trigger signaling pathways, or it can allow the virion to be carried by the host cell to a specific organ ...
Video created by Duke University for the course Introductory Human Physiology. Welcome back! In this module we consider how the circulatory system works to deliver oxygen and nutrients to the specific organs. We start with a discussion of the ...
Plastic Surgery Procedures Available Surgical procedures that people undertake to alter their appearance or that of specific organs in their body is known as
Author: Brian Hoyle The skin-the body's largest organ- teems with an unexpectedly broad variety of bacterial species, according to Martin Blaser of New York University (NYU) School of Medicine in New York, N.Y., and his collaborators. "There has been a lot of work on the gastrointestinal tract … but, in contras... More... ...
Comprehensive collection of high-quality human total protein extracts ready for electrophoresis. Quickly confirms tissue-specific abundance of your protein. Easily accesses hard-to-obtain human tissues, including brain regions and fetal tissues.
Comprehensive collection of high-quality human total protein extracts ready for electrophoresis. Quickly confirms tissue-specific abundance of your protein. Easily accesses hard-to-obtain human tissues, including brain regions and fetal tissues.
TP53TG3, 0.1 ml. May play a significant role in TP53/p53-mediating signaling pathway.Tissue specificity:Strongly expressed in testis.
Lysine acetylation is a major posttranslational modification involved in a broad array of physiological functions. Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass spectrometry. We quantify 15,474 modification sites on 4,541 proteins and provide the data set as a web-based database. We demonstrate that lysine acetylation displays site-specific sequence motifs that diverge between cellular compartments, with a significant fraction of nuclear sites conforming to the consensus motifs G-AcK and AcK-P. Our data set reveals that the subcellular acetylation distribution is tissue-type dependent and that acetylation targets tissue-specific pathways involved in fundamental physiological processes. We compare lysine acetylation patterns for rat as well as human skeletal muscle biopsies and demonstrate its general involvement in muscle contraction. Furthermore, we illustrate that acetylation of fructose-bisphosphate aldolase and ...
Fingerprint Dive into the research topics of Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. Separation from aspartate aminotransferase isoenzymes. Together they form a unique fingerprint. ...
The ability to resolve protein members of the hsp70 multigene family by two-dimensional Western blotting permitted the characterization of antibodies which were specific in discriminating constitutively expressed hsc70 isoforms from stress-inducible hsp70 isoforms. This antibody characterization demonstrated that basal levels of hsp70 isoforms were present in the cerebellum of the control rabbit and that these were elevated following hyperthermia, whereas levels of hsc70 were similar in control and hyperthermic tissue. Multiple isoforms of hsp70 were detected but tissue-specific differences were not apparent in various organs of the rabbit. However, species differences were observed as fewer hsp70 isoforms were noted in rat and mouse. In the control rabbit, higher levels of hsc70 protein were present in neural tissues compared to non-neural tissues. Following physiologically relevant hyperthermia, induction of hsp70 was greatest in non-neural tissues such as liver, heart, muscle, spleen, and kidney
From NCBI Gene:. The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]. From UniProt: ...
Tissue specific architecture of nutrient dependent responses in D. melanogaster. The overall aim of this project is to examine the role of tissue-specific changes in mRNA translation in response to dietary restriction (DR) and to examine their role in modulating metabolism, muscle activity and healthspan using D. melanogaster. We have previously demonstrated that modulation of mRNA translation is a key output of the TOR pathway that mediates DR responses on metabolism and lifespan. We have now established a ribotag based method in D. melanogaster to study tissue-specific mRNA translation. Tissue-specific mRNAs are isolated following ribosome affinity purification of tissue-specific tagged ribosomal proteins followed by polysomal profiling. Using this Ribotag approach tissue-specific changes under DR have been measured in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR. We are developing mechanistic models of gene expression ...
Skeletal muscle tissue forms the muscles which are attached to the bones, these muscles are voluntary, which means they can be controlled with conscious thought, and they help us to walk, run, or move our body in some other way. The smooth and cardiac muscle tissue are involuntary, which means they are not controlled by conscious thought, they work automatically. Connective tissue provides support throughout the body. The main purpose of connective tissue is to join together the other tissues of the body. It connects the bone to the muscle with tendons, and the bones to other bones with ligaments. It also can keep two bones from rubbing together, like the cartilage between the vertebrae in the spinal column and the joints. Nerve tissue gives your body control. It sends out signals for information and processes data coming into the brain from different areas of the body. Some scientists also consider the blood and lymph fluid to be tissue, it is responsible for carrying nutrients all through the ...
Researchers identify important molecular players for the formation of embryonic cell structures Understanding the molecular mechanisms underlying the mesmerising transformation of a fertised egg into a complex organism is a key goal of developmental biology, and one driving extensive investigations. Different tissues and organs derive from three primordial germ layers: endoderm, mesoderm and ectoderm. How do they become specified, and how do they subsequently diversify to form different structures? Researchers of the CRTD teamed up with international scientists to investigate this question together with international colleagues. In particular, they addressed the lateral plate mesoderm (LPM) - the germ layer that gives rise to the cardiovascular, blood, kidney and smooth muscle cell fates among others, and whose origin was poorly understood.. Through a combination of genetic tools and live imaging techniques, the scientists identified a small enhancer of the zebrafish-specific gene draculin (drl) ...
actually the cause has to do with the adaptation of the eye to light. the darkness causes all the retinen in cone cells to associate with its opsin partner, leading to an increased sensitivity of the cell to intense light. When the light is turned on, it overwhelms the receptor. It takes a few minutes for the eye to adapt and to switch from rod cells to cone cells. I believe the term for this is receptor up-regulation ...
C) no, not necessarily... it depends how much damage there is... but pain sensation is both a physiological and psychological responce... many people have very traumatic sports injuries and they dont feel the pain to much after the event... as adrenaline may well delay a pain responce... but we also have other endogenous pain killers in bodies (endogenous opioids, neurotransmitters...etc ...
Technical information on organs like specification, type of construction, pipe measurements etc.. Historical information on organs. Very often when an organ was built, parts of the previous instrument were reused by enlarging and restoring the organ, for instance, or replacing certain stops. Also, organs or parts of organs were sold from one church to another. It is important to store these changes to an instrument in order to document the development of a specific organ.. Archive information consisting of (1) written documents containing letters, contracts, descriptions, documentations, etc. and (2) picture documents containing photos, paintings, drawings, etc. Proposals, contracts, descriptions, letters from various authorities, the parish, the organ builder, the organist or the organ expert are an important background to the decisions made when building, restoring or repairing an organ.. Person information. Information on organ builders, organists, companies etc. that in one way or another ...
This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. You understand what makes a tissue specific and depict key signaling pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors.