Organ of Corti. Coloured scanning electron micrograph (SEM) of the organ of Corti from the cochlea of the inner ear. The bony capsule that encloses the organ has been removed to reveal the organs spiral structure. Rows of sensory hairs within the organ of Corti convert sound vibrations into nerve impulses that are sent along the auditory nerve to the brain. Different sound frequencies stimulate hairs in different positions along the spiral. Low frequencies stimulate those near the top of the spiral and high frequencies stimulate those near the bottom. - Stock Image C001/2656
Organ of Corti. Coloured scanning electron micrograph (SEM) of sensory hair cells from the organ of Corti, in the cochlea of the inner ear. These are the outer rows of hairs. These cells are surrounded by a fluid called the endolymph. As sound enters the ear it causes waves to form in the endolymph, which in turn cause these hairs to move. The movement is converted into an electrical signal, which is passed to the brain. Each V- shaped arrangement of hairs lies on the top of a single cell. Magnification: x8000 when printed 10cm wide. - Stock Image C026/0622
Genome analyses can uncover protein-coding changes that potentially underlie the differences between species, but many of the phenotypic differences between species are the result of regulatory mutations affecting gene expression. In this collaborative study headed by Prof. Henrik Kaessmann group (CIG, UNIL) we used high-throughput RNA sequencing to study the evolutionary dynamics of mammalian transcriptomes in six major tissues (cortex, cerebellum, heart, kidney, liver and testis) from ten species from all major mammalian lineages. Among the findings is the extent of transcriptome variation between organs and species, as well as the identification of potentially selectively driven expression switches that may have shaped specific organ biology. Notably for the first time we applied the Iterative Signature Algorithm (ISA) to RNAseq data identifying transcriptional units (modules) including subsets of orthologous genes that have conserved expression patterns across different sets of organs in ...
The model shows a three dimensional section through the organ of Corti, the site of the sense of hearing in the inner ear in humans.Depicting functions and locations, the human biology models allow individuals a more comprehensive understanding of internal organs and systems. Blood movement, oxygen transport, muscle constriction, nerve firing, joint movement, and bone formation are brought to life in these incredibly detailed and accurate representations. Musculature models come colored coded for easy identification of muscle, fat, ligaments, and tendons. The human biology models can be used in both educational and clinical environments.
This procedure describes a method for the isolation and culture of the murine organ of Corti with or without the spiral limbus and...
Spieker, L E; Flammer, A J; Amacker, N; Sudano, I; Badimon, J J; Ruschitzka, F; Luscher, T F; Noll, G; Corti, R (2006). C-reactive protein influences shear stress-dependent platelet adhesion in patients with familiar hypercholesterolemia and coronary artery disease undergoing LDL apheresis. Thrombosis and Haemostasis, 96(4):540-542.. Sudano, I; Spieker, L E; Noll, G; Corti, R; Weber, R; Lüscher, T F (2006). Cardiovascular disease in HIV infection. American Heart Journal, 151(6):1147-1155.. Hermann, F; Spieker, L E; Ruschitzka, F; Sudano, I; Hermann, M; Binggeli, C; Lüscher, T F; Riesen, W; Noll, G; Corti, R (2006). Dark chocolate improves endothelial and platelet function. Heart, 92(1):119-120.. Sudano, I; Spieker, L E; Hermann, F; Flammer, A; Corti, R; Noll, G; Luscher, T F (2006). Protection of endothelial function: targets for nutritional and pharmacological interventions. Journal of Cardiovascular Pharmacology, 47 Sup:S136-S150.. Spieker, L E; Ruschitzka, F; Lüscher, T F; Noll, G (2004). ...
Mammalian organs are built of a variety of intermingled cell types, the full extent and diversity of which are unknown. Specification and maintenance of cell id...
Cincinnati Childrens-led study opens way for new research of development, disease Tuesday, 11 November 2008 Researchers have generated the first comprehensive genetic blueprint of a forming mammalian organ, shedding light on the genetic and molecular dynamics of kidney development. Part of an international consortium sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a research team led by Cincinnati Childrens Hospital Medical Center reports the creation of a detailed genome-based atlas for understanding healthy and abnormal kidney development and disease. Published in the Nov. 11 Developmental Cell and featured on the journals cover, the research provides a molecular genetic map detailing "gene expression analysis of all the major elements of kidney formation," according to the investigators. The study, involving embryonic mice, shows how the entire genome is regulated to produce thousands of specific genes that are mixed and re-mixed to form genetic ...
Previously, researchers haveidentified a key protein, called p16INK4a, that increase in mammalian organs as as cells and tissues age. Recently, they have found out that the protein is also present in human blood and is strongly correlated both with chronological age and with certain behaviors such as tobacco use and physical inactivity, which are known to accelerate the aging process. Based on these findings, they have developed a simple blood test to detect p16p16INK4a expression, which is present in cells called T-lymphocytes, also known as T-cells.. They found that expression of the biomarker was strongly correlated with the donors chronological age and, in fact, increased exponentially with age. In addition, increased levels were independently associated with tobacco use and physical inactivity as well as with biomarkers of human frailty.. Sharpless said that the researchers were surprised by some of their findings, "We found a very weak correlation between the biomarker and obesity - as ...
Com mais de 65 anos de tradição no mercado nacional e internacional, os produtos Firmo acompanham gerações e tornaram-se ícones indissociáveis da marca, como o Caderno Azul, o Caderno Capa Preta, a Sebenta ou mesmo o Caderno de Estudos.. ...
J:117235 Hayashi T, Cunningham D, Bermingham-McDonogh O, Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn. 2007 Feb;236(2):525-33 ...
Pietzsch J, Scheid JF, Mouquet H, Klein F, Seaman MS, Jankovic M, Corti D, Lanzavecchia A, Nussenzweig MC. 2010. Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness.. J Exp Med. 207(9):1995-2002. ...
Applicazioni biomediche della Risonanza Magnetica e dei Materiali Magnetici University researchers involved (NMR group, Dip. Fisica, UNIPV, : Seniors : Borsa F., Carretta P., Corti
Neurosensory development requires the sequential, coordinated activation and cross-regulation of numerous transcription factors (TFs) to define precursors and initiate differentiation of the various cell types of the nervous and sensory system (Fritzsch et al., 2015; Imayoshi and Kageyama, 2014; Reiprich and Wegner, 2015). Molecularly dissecting these interactions requires model systems with limited cellular diversity and stereotyped cellular patterning. The organ of Corti (OC) is such a model system, with hair cells (HCs) and supporting cells (SCs) organized into the most stereotyped cell assembly of vertebrates (Slepecky, 1996), and is suited to detect minute aberrations (Jahan et al., 2013). The stereotyped cellular pattern may allow the molecular dissection of the intricate interaction of multiple basic helix-loop-helix (bHLH) proteins (Benito-Gonzalez and Doetzlhofer, 2014; Fritzsch et al., 2010b) to define HCs/SCs.. Targeted deletion studies in mice have demonstrated that three bHLH TFs ...
The avian basilar papilla is composed of hair and supporting cells arranged in a regular pattern in which the hair cells are surrounded and isolated from each other by supporting cell processes. This arrangement of cells, in which the apical borders of hair cells do not contact one another, may be generated by contact-mediated lateral inhibition. Little is known, however, about the way in which hair and supporting cells are organized during development. Whole mounts double-labeled with antibodies to the 275 kDa hair-cell antigen and the tight junction protein cingulin were therefore used to examine the development of cell patterns in the basilar papilla. Hair cells that contact each other at their apical borders are seen during early development, especially on embryonic days (E) 8 and 9, but are no longer observed after E12. Hair and supporting cell patterns were analyzed in three different areas of the papilla at E9 and E12. In two of these regions between E9 and E12, the ratio of supporting ...
The organ of Corti is the sensitive element in the inner ear and can be thought of as the bodys microphone. It is situated on the basilar membrane in one of the three compartments of the Cochlea. It contains four rows of hair cells which protrude from its surface. Above them is the tectoral membrane which can move in response to pressure variations in the fluid- filled tympanic and vestibular canals. There are some 16,000 -20,000 of the hair cells distributed along the basilar membrane which follows the spiral of the cochlea. ...
The inner ear contains the auditory and vestibular organs, which are sensory neuroepithelia composed of mechanosensory hair cells and glia-like supporting cells. The mammalian auditory sensory epithelium, the organ of Corti, is responsible for transduction of sound stimuli into electrical signals for hearing function. Hair ...
The observed disorganization and expansion of the organ of Corti, in addition to the proliferation following ectopic β-catenin activation, suggested changes in the adhesion complexes within the epithelium. In addition to roles in proliferation and differentiation, β-catenin plays a role in cell adhesion by binding to the cytoplasmic tail of cadherins at the plasma membrane (Ozawa et al., 1989). Similar to β-catenin, E-cadherin is expressed within the cell membranes of the cochlear sensory epithelium (Whitlon, 1993; Leonova and Raphael, 1997; Simonneau et al., 2003). When we overexpressed β-catenin in the cochlea after initiation of tamoxifen at E13.5 in the Sox2-CreER;β-cateninflox(exon3) mouse, elongation of the sensory epithelium proceeded into the apical region (Fig. 8A) as expected, and staining for EdU as well as Ki67, a cell proliferation marker, were observed (Fig. 8B), but E-cadherin expression within the cell membranes was decreased (Fig. 8C,E). The cochlea contained multiple rows ...
Following the loss of hair cells from the mammalian cochlea, the sensory epithelium repairs to close the lesions but no new hair cells arise and hearing impairment ensues. For any cell replacement strategy to be successful, the cellular environment o
The first time I saw Jim Corti was in Miami, on a hot, sticky night in May 1989. We were both seated in the restaurant at the Howard Johnsons motel on the north edge of the city, a rather sad establishment that had seen too many humid, tropical summers since the last paint job. We were at separate tables, eyeing each other from time to time. I was alone. Corti sat with three other men. We had not yet been introduced and were not sure how to recognize each other.. I had come to witness and record an underground treatment of four HIV-positive gay men, two with AIDS, who had volunteered to be injected with a promising but possibly deadly Chinese drug. Corti, I had been told, was a famous, or at least notorious, crusader. A doctor, one person told me. A nurse, said another. In fact, by his own account, a nurse and a smuggler.. Corti and a small alliance of gay men have been pressing the limits of the federal Food and Drug Administrations tolerance since 1985 when they began importing unauthorized ...
Definition of Corti auditory teeth. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
The urotensinergic system plays central roles in the physiological regulation of major mammalian organ systems, including the cardiovascular system. As a matter of fact, this system has been linked to numerous pathophysiological states including atherosclerosis, heart failure, hypertension, diabetes as well as psychological and neurological disorders. The delineation of the (patho)physiological roles of the urotensinergic system has been hampered by the absence of potent and selective antagonists for the urotensin-II receptor (UT). Thus, a more precise definition of the molecular functioning of the urotensinergic system, in normal conditions as well as in a pathological state is still critically needed. The recent discovery of nuclear UT within cardiomyocytes has highlighted the cellular complexity of this system and suggested that UT-associated biological responses are not only initiated at the cell surface but may result from the integration of extracellular and intracellular signalling pathways. Thus
hair cell definition: A cell inside organ of Corti having good hairlike processes.; a sensory epithelial cellular contained in the organ of Corti
Cochlea - This is a spirally coiled tube containing fluid and the actual organ of hearing, the Organ of Corti. Each organ of Corti contains thousands of hairs that are vibrated by the sound waves. The hairs then initiate nervous impulses in the Auditory Nerve which is connected to the auditory areas on the sides of the brain ...
A pressure relieving pad with graduated pillars to effectively reduce the development of decubitus ulcers. The pad is preferably made of foam to keep the manufacturing costs down and includes a first plurality of large pillars or columns. A second plurality of smaller pillars or columns is then positioned atop each of the larger pillars forming a progression or graduation of pillars. Adjacent larger pillars are preferably attached to one another at their bases to form an underlying, support platform or level for the pad. In operation, the weight or force of the patient using the pad is progressively transferred from the small pillars on top downwardly through the larger pillars to the underlying support platform or level.
I found that, knew about that. But there was no mention of it in the "In Memory Of". A climber died, theres an intriguing story that underscores his death and maybe others appreciate it as well ...
Einleitung: Salizylat kann Mensch und Tier vor den unerwünschten Nebenwirkungen des Antibiotikums Gentamicin schützen. Der protektive Mechanismus ist weitgehend unklar und bedarf weiterer Untersuchung. In vitro konnten wir zeigen, dass Salizylat Corti´sche Organe (OC) neugeborener Ratten[for full text, please go to the a.m. URL ...
S. Mion, C. Corti, A. Neki, R. Shigemoto, M. Corsi, G. Fumagalli, F. Ferraguti, Molecular and Cellular Neuroscience 17 (2001) 957-972 ...
by Aguilar, M and Cavasonza, L. Ali and Ambrosi, G and Arruda, L and Attig, N and Aupetit, S and Azzarello, P and Bachlechner, A and Barao, F and Barrau, A and Barrin, L and Bartoloni, A and Basara, L and Başeğmez-du Pree, S and Battarbee, M and Battiston, R and Becker, U and Behlmann, M and Beischer, B and Berdugo, J and Bertucci, B and Bindel, K. F and Bindi, V and de Boer, W and Bollweg, K and Bonnivard, V and Borgia, B and Boschini, M. J and Bourquin, M and Bueno, E. F and Burger, J and Cadoux, F and Cai, X. D and Capell, M and Caroff, S and Casaus, J and Castellini, G and Cervelli, F and Chae, M. J and Chang, Y. H and Chen, A. I and Chen, G. M and Chen, H. S and Chen, Y and Cheng, L and Chou, H. Y and Choumilov, E and Choutko, V and Chung, C. H and Clark, C and Clavero, R and Coignet, G and Consolandi, C and Contin, A and Corti, C and Creus, W and Crispoltoni, M and Cui, Z and Dadzie, K and Dai, Y. M and Datta, A and Delgado, C and Della Torre, S and Demirköz, M. B and Derome, L and Di ...
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Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats
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Noisy Pillars (I Should Have Told You mix) - c64 remix by Mordi. Original by Jeroen Tel. Released |span itemprop=datePublished content=1223804494|12/10/2008|/span|. Lyrics: Running just as far as you can.Beating on my heart.Its all he wants, so.Running just as far as you can. I dont want to wanna no more.I cant take, take no more.(x2). I should have told you.You make the difference.I should have told you.You ...
When Yoda fights Dooku on Geonosis, Dooku causes a pillar to fall on Obi and Ani. Yoda stops and lifts the pillar off them while Dooku escapes. Why did...
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Regeneration of sensory hair cells in the mature avian inner ear was first described just over 20 years ago. Since then, it has been shown that many other non-mammalian species either continually produce new hair cells or regenerate them in response to trauma. However, mammals exhibit limited hair cell regeneration, particularly in the auditory epithelium. In birds and other non-mammals, regenerated hair cells arise from adjacent non-sensory (supporting) cells. Hair cell regeneration was initially described as a proliferative response whereby supporting cells re-enter the mitotic cycle, forming daughter cells that differentiate into either hair cells or supporting cells and thereby restore cytoarchitecture and function in the sensory epithelium. However, further analyses of the avian auditory epithelium (and amphibian vestibular epithelium) revealed a second regenerative mechanism, direct transdifferentiation, during which supporting cells change their gene expression and convert into hair cells without
TY - JOUR. T1 - The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. AU - Kim, Sung Kyun. AU - Im, Gi Jung. AU - An, Yun Suk. AU - Lee, Se Hee. AU - Jung, Hak Hyun. AU - Park, Sang Yoo. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Conclusion: D-α-tocopherol succinate significantly reduced a cisplatin-induced hair cell loss in HEI-OC1 cell lines. These effects were mediated by its scavenging activity against reactive oxygen species (ROS) and inhibition of apoptosis. Objectives: Alpha-tocopherol is a class of methylated phenols, known as fat-soluble antioxidants, and is a different form of vitamin E, which reduces free radicals and acts as an antioxidant. We hypothesized that the antioxidative effect of α-tocopherol could protect against cisplastin-induced cytotoxicity, and thus evaluated its effects on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Methods: HEI-OC1 cells were pretreated with D-α-tocopherol succinate at a ...
Bartleby: The Internal Ear or Labyrinth (Auris Interna) The Cochlea: apex (cupula), modiolus, osseous spiral lamina, basilar membrane, helicotrema, spiral canal of the modiolus, spiral ganglion (Ganglion of Corti), fenestra cochle , secondary tympanic membrane, osseous spiral lamina (lamina spiralis ossea), scala vestibuli, scala tympani, hamulus lamin spiralis, secondary spiral lamina, vestibule fissure, Ductus Cochlearis (membranous cochlea; scala media), basilar membrane, vestibular membrane, lagena, spiral ligament, basilar crest, spiralis externus, stria vascularis, osseous spiral lamina, imbus lamin spiralis, sulcus spiralis internus, vestibular lip, tympanic lip, auditory teeth, Basilar Membrane, zona arcuata, spiral organ of Corti, zona pectinata, vas spirale, Corti s tunnel, piral organ of Corti (organon spirale; organ of Corti), inner and outer rods or pillars of Corti, tunnel of Corti, reticular membrane, Rods of Corti, inner rods, outer rods, phalangeal processes, phalangeal ...
Subject: Re: Efferent feedback to the organ of the Corti From: Matt Flax ,flatmax(at)IEEE.ORG, Date: Fri, 11 Oct 2002 01:17:48 +1000 David, please forgive me if I am incorrect. I am referring to [1] Figure 5 where the VR/NP Synapses on VP/NR NFs (Presumed Axodendritic Synapses) are depicted to become less numerous towards the 3rd turn. Again, I am an electrical engineer, so please forgive me if I am mistaken, but I am assuming that these are efferent neural connections. I also refer to this posting to Auditory in 1996 : http://www.auditory.org/postings/1996/74.html Where it is stated ... "There are also efferent fibers near the IHCs. These originate in the lateral olivocochlear system, and make axodendritic synapses with the afferent fibers [3]". Matt [3] Nadol J.B., Jr., Synaptic morphology of inner and outer hair cells of the human organ of Corti, Journal of electron microscopy technique, 15, 187-196, 1990. [1] (at)article{Thiers:2002, author = {Thiers, F.A. and Burgess, B.J. and Nadol, ...
In guinea pigs, an acute acoustic trauma was created by 6 consecutive gunshots. The sound pressure at the ear drum was 156 +/- 4 dB, the frequency maximum was between 4 and 6 kHz. Sixty hours after the noise trauma, the animals were decapitated, and the cochleae were prepared for microscopic analysis of the resulting trauma to the organ of Corti. During the process of fixation, the potassium-pyroantimonate precipitation reaction was performed to localize calcium-binding sites. The pattern of cell morphology and the distribution of calcium-binding sites was compared to that of normal control animals. Morphologic changes of the cells in the organ of Corti correlated with changes of the cellular calcium distribution, indicating the crucial role of calcium in cell damage and necrosis after acute noise trauma.
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The decade since the publication of the third edition of this volume has been an era of great progress in biology in general and the plant sciences in particular. This is especially true with the advancements brought on by the sequencing of whole genomes of model organisms and the development of omics techniques. This fourth edition of Plant Roots: The Hidden Half reflects these developments that have transformed not only the field of biology, but also the many facets of root science. Highlights of this new edition include: The basics of root research and their evolution and role in the global context of soil development and atmosphere composition New understandings about roots gained in the post-genomic era, for example, how the development of roots became possible, and the genetic basis required for this to occur The mechanisms that determine root structure, with chapters on cellular patterning, lateral root and vascular development, the molecular basis of adventitious roots, and other topics
The decade since the publication of the third edition of this volume has been an era of great progress in biology in general and the plant sciences in particular. This is especially true with the advancements brought on by the sequencing of whole genomes of model organisms and the development of omics techniques. This fourth edition of Plant Roots: The Hidden Half reflects these developments that have transformed not only the field of biology, but also the many facets of root science. Highlights of this new edition include: The basics of root research and their evolution and role in the global context of soil development and atmosphere composition New understandings about roots gained in the post-genomic era, for example, how the development of roots became possible, and the genetic basis required for this to occur The mechanisms that determine root structure, with chapters on cellular patterning, lateral root and vascular development, the molecular basis of adventitious roots, and other topics
Here, too, sensory differentiation appears to need the presence of dendrites from the associated spiral ganglion (ganglion of Corti), and in month 5, fissures in these groups of cells make their appearanc One fissure forms the spiral sulcus, which clearly separates the organ of Corti from the limbus, and the other produces the canal of Corti which isolates the inner ciliated cells from the outer ciliated ...
The Beginning. Cryobiologists and cryonicists were not always at war with each other. Indeed, many might question why there is a war at all between two groups of people with similar objectives and a common purpose: the development of mammalian suspended animation, or at least suspended animation for mammalian organs via cryopreservation. The desire of cryonicists is to have available a technology which will allow them access to medical time travel (albeit one-way time travel) and cryobiologists are the most logical group of scientists capable of delivering that technology. At first glance these two groups should be natural allies, not enemies. Logically, cryobiologists should have looked to cryonicists as a possible strong and unwavering source of support in achieving their research objectives, just as they have looked to the organ transplant community for such support. Certainly there are many examples in other areas of society and science where special interest groups have worked with ...
Sensory receptors in the organ of Corti in the inner ear. They convert the mechanical vibration caused by sound into electrical signals which are transmitted to the brain by the auditory nerve.. ...