Left lateral view of orbital structures at the orbital apex and superior orbital fissure. Bone has been selectively removed to demonstrate...
Glucocorticoids (GCs) have a profound effect on adipose biology increasing tissue mass causing central obesity. The pre-receptor regulation of GCs by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) that activates cortisol from cortisone has been postulated as a fundamental mechanism underlying the metabolic syndrome mediating adipocyte hyperplasia and hypertrophy in the omental (OM) depot. Orbital adipose tissue (OF) is the site of intense inflammation and tissue remodelling in several orbital inflammatory disease states. In this study, we describe features of the GC metabolic pathways in normal human OF depot and compare it with subcutaneous (SC) and OM depots. Using an automated histological characterisation technique, OF adipocytes were found to be significantly smaller (parameters: area, maximum diameter and perimeter) than OM and SC adipocytes (P|0 x 001). Although immunohistochemical analyses demonstrated resident CD68+ cells in all three whole tissue adipose depots, OF CD68 mRNA and
TY - JOUR. T1 - Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy. AU - Salvi, M.. AU - Miller, A.. AU - Wall, J. R.. PY - 1988/5/9. Y1 - 1988/5/9. N2 - A 64 kDa protein has been identified in the membrane fraction of human eye muscle, orbital connective tissue and thyroid, by testing sera of patients with thyroid-associated ophthalmopathy in SDS-polyacrylamide gel electrophoresis and Western blotting. Antibodies to this membrane antigen seem characteristic of the early stage of ophthalmopathy. In the thyroid this newly recognized protein seems different from previously known membrane antigens. A thyroid antibody reactive with a 64 kDa membrane antigen in eye muscle could explain the very frequent association of ophthalmopathy with autoimmune thyroid disease.. AB - A 64 kDa protein has been identified in the membrane fraction of human eye muscle, orbital connective tissue and ...
TY - JOUR. T1 - Orbitocranial wooden foreign body diagnosed by magnetic resonance imaging. Dry wood can be isodense with air and orbital fat by computed tomography. AU - Specht, Charles S.. AU - Varga, John H.. AU - Jalali, Michael M.. AU - Edelstein, Jeffrey P.. PY - 1992/1/1. Y1 - 1992/1/1. N2 - In computed tomographic (CT) scans, a wooden foreign body can appear as a lucency with nearly the same density as air or fat, and it can be indistinguishable from orbital adipose tissue. Magnetic resonance imaging (MRI) can localize these wooden foreign bodies in the orbit. We studied a case in which a wooden golf tee lodged in the right optic canal of a nine-year-old boy. The head portion lodged in the orbital apex and the tip entered the interpeduncular fossa. Clinical examination revealed a right paranasal laceration; the right eye had no light perception and a peripapillary hemorrhage, but was otherwise normal. Surgical exploration and evaluation by CT failed to locate the foreign body. However, ...
Orbital injury and complications are commonly encountered in endoscopic sinus surgery (ESS) despite advances in techniques and instrumentation. For the recent 10 years, we summarized the experience of the rhinology unit of our department regarding orbital injury and complications of ESS for sinonasal inflammatory disorders. One thousand seventy-three patients (1869 sides) from January 1, 2003 to December 31, 2012 undergoing ESS for sinonasal inflammatory diseases were enrolled in the present study. The age of the patients ranged from 8 to 81 years, mean age 49 years. Orbital injury and complications were observed in 13 patients (13 sides), which corresponded to 0.7% of the operated sides and 1.2% of the patients. Eight patients showed herniation of orbital fat alone through the injury of the lamina papyracea. The protruding orbital fat was snipped and cut using forceps in 2 patients. Removal of exposed orbital fat using powered instruments was performed in 3 patients, two of whom transiently showed
Superior orbital fissure syndrome information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
The purpose of this protocol is to study orbital structures in Graves´ Disease using multidetector computed tomography and color doppler imaging.. Some changes in orbital structures detected by imaging exams could predict severity of the ocular Graves´disease. Thus the study could be useful in improve medical management of patients with Graves´ Disease. ...
TY - JOUR. T1 - Correlation between orbital volume, body mass index, and eyeball position in healthy East Asians. AU - Yoo, Jun Ho. AU - Lee, Young Hen. AU - Lee, Hwa. AU - Kim, Jung Wan. AU - Chang, Minwook. AU - Park, Minsoo. AU - Baek, Se Hyun. PY - 2013/5/1. Y1 - 2013/5/1. N2 - PURPOSE: The objectives of this study were measure the orbital volume of healthy Koreans and analyze the differences between orbital tissue volume with respect to age and sex and to assess any correlation between body mass index (BMI), eyeball position, and orbital volume. METHODS: We retrospectively evaluated the scan results of patients who had undergone orbital computed tomography scans between November 2010 and November 2011. We assessed the scan results of 184 orbits in 92 adults who had no pathology of the orbit. The individuals were classified into 3 groups with respect to age. Orbital volume, effective orbital volume (defined as the difference between orbital and eyeball volume), extraocular muscle volume, ...
A decision was made for a left transcranial orbitotomy with a cranio-orbital approach for removal of the foreign body. The posterior location of the pellet in the orbital apex eliminated an anterior orbitotomy approach. A lateral approach could have been used yet it would have required an osteotomy extending along the lateral orbital wall that was posteriorly fragmented. This would have required enlarging the bony incision of a classic lateral orbitotomy and removing the sphenoid wing to the superior orbital fissure, as described by Goldberg et al.(5) This approach would have eliminated the need for a craniotomy; however, it was possible that this might not have provided enough access and exposure to safely extract the pellet. A multidisciplinary team included our neurosurgery service who performed a left transcranial orbitotomy with a cranio-orbital approach and provided access for our oculoplastic surgery team. A cranio-orbital approach allowed for direct visualization of the superior orbital ...
A decision was made for a left transcranial orbitotomy with a cranio-orbital approach for removal of the foreign body. The posterior location of the pellet in the orbital apex eliminated an anterior orbitotomy approach. A lateral approach could have been used yet it would have required an osteotomy extending along the lateral orbital wall that was posteriorly fragmented. This would have required enlarging the bony incision of a classic lateral orbitotomy and removing the sphenoid wing to the superior orbital fissure, as described by Goldberg et al.(5) This approach would have eliminated the need for a craniotomy; however, it was possible that this might not have provided enough access and exposure to safely extract the pellet. A multidisciplinary team included our neurosurgery service who performed a left transcranial orbitotomy with a cranio-orbital approach and provided access for our oculoplastic surgery team. A cranio-orbital approach allowed for direct visualization of the superior orbital ...
Purpose: : Thyroid Eye Dsease is characterized by infiltration of white blood cells and accumulation of nonsulfated glycosaminoglycan hyaluronan (HA) in orbital tissue. The inflamed orbital tissue can become full of scar and fat tissue. Transforming growth factor beta (TGFβ) acts as a key inducer of the fibrotic response by enhancing extracellular matrix production. Peroxisome proliferator-activated receptor gamma (PPARγ) ligands have anti-inflammatory and antifibrotic activities. In this study, we hypothesized that TGFβ would induce HA synthesis/secretion and that PPARγ ligands would inhibit this response in orbital fibroblasts. Methods: : Primary orbital fibroblasts were isolated from individual Graves patients undergoing orbital decompression surgery. The cells were grown in RPMI media containing 10%FBS. The amount of HA in the cell culture supernatant was measured by ELISA. HA synthase (HAS) mRNA expression was analyzed by real-time RT-PCR. Results: : Treatment of human orbital ...
TY - JOUR. T1 - Orbital Trauma Caused by Bicycle Hand Brakes. AU - Ng, John. AU - Payner, Troy D.. AU - Holck, David E E. AU - Martin, Ronald T.. AU - Nunery, William T.. PY - 2004/1. Y1 - 2004/1. N2 - Purpose: This report aims to increase awareness of an unusual mechanism of orbital injury sustained by bicycle riders. Methods: In this retrospective small case series, we describe two cases of orbital injury caused by upper eyelid penetration. A 5-year-old boy (patient 1) and a 6-year-old boy (patient 2) presented to our service within a 2-week period. Both had been injured by similarly styled, handlebar-mounted bicycle hand brake levers. Patient 1 had an orbital roof fracture and penetrating brain injury and underwent repair of a left upper eyelid laceration, craniotomy for pseudoencephalocele, and ptosis repair. Patient 2 had orbital hemorrhage and underwent repair of left upper eyelid laceration. Results: In both cases, a handlebar-mounted bicycle hand brake lever perforated the left eyelid ...
Results Mean logarithm of the minimum angle of resolution (logMAR) VA increased, statistically significantly, by 2.4 lines during 30±13 months (from 0.38±0.25 before surgery to 0.14±0.1 at the end of observation, p=0.0001). All eyes maintained or improved vision by at least one line. Mean postoperative reduction of proptosis was 6.4±3 mm. While VECP P100 amplitudes improved significantly, P100 latencies remained abnormal in 18 eyes (60%) during follow-up of 10±7 months. Nine eyes (30%) with previous latency defects improved in at least one check test, five of which normalised completely. Worsening was evident in seven eyes (23%), and three previously normal eyes developed new pathological latencies. P100 latencies in 14 eyes (47%) remained unchanged. ...
Please cite this website and data as: Botha CP, Willekens B, Klooster J, IJskes SG, Hötte G, Simonsz HJ: The Visible Human Orbit: Digital high-resolution conservation of anatomical serial sections of the human embryonal and adult orbit by Koornneef, Los and de Haan. www.visible-orbit.org, 2012.. Affiliations: From the Dept. of Intelligent Systems, Delft University of Technology, (Botha); The Netherlands Institute for Neuroscience of the Royal Netherlands Academy for Arts and Sciences, Amsterdam (Willekens, Klooster, IJskes, Simonsz) and the Department of Ophthalmology, Erasmus Medical Center, Rotterdam (Hötte, Simonsz).. ...
Definition : Ophthalmic implants designed for the total or partial reconstruction and/or augmentation of the extraocular rim, including the inferior (i.e., orbital floor), lateral (i.e., orbital wall), and superior parts of the rim. These implants are manufactured in a variety of sizes and shapes according to the intended use; they are typically made of high-density polymers (e.g., polyethylene) that are frequently reinforced with an embedded metal (usually titanium) mesh. The implants can be trimmed to fit the patients orbital anatomy. Dedicated orbital rim implants are available for use in procedures such as reconstruction of the orbital floor and wall augmentation of the inferior and lateral rim, augmentation of the lateral and superior or orbital rims in patients who are hypoplasic, and to support the lower eyelid and lateral canthus in patients who have inadequate support. These implants are used mainly to repair traumatic damage (e.g., fractures), to improve the function of the eyes, or ...
In a finite element analysis of orbital tissue mechanics, Schutte et al. 29 estimated the elastic modulus, which is equivalent to long-term stiffness in the present study, for intraconal and extraconal retrobulbar fat to be 0.3 and 1.0 KPa, respectively. Although muscle cone as a demarcating structure in the deep orbit is an anatomic fiction, 30 the bovine orbital fatty tissue in current investigation may correspond to what Schutte et al. 29 termed intraconal retrobulbar fat. The present study determined the long-term stiffness of human orbital fat to be 0.71 KPa, which is of similar magnitude to that reported by Schutte et al. 29 A more important observation of the current investigation, however, was similarity in the stiffness of normal human and bovine orbital fatty tissue. As can be seen in Table 1, the long-term stiffness of human orbital fatty tissue and bovine orbital fatty tissue are similar at 0.74 and 0.71 KPa, respectively. Although there is ,5% difference in long-term stiffness ...
As quotable as 2001: A Space Odysseys HAL is, hes not a character whose shoes - erm, digital footprint - many games have allowed us to fill. Human Orbit
Top 10 tissues for NP_777555 (Homo sapiens, RefSeq): retina, cerebellum, lacrimal gland, metencephalon, orbital adipose tissue, hindbrain (rhombencephalon), eye, suprabasal epidermis cell, peripheral blood T-cell (unspecified), peripheral blood CD4 stem cell memory T-cell
Top 10 tissues for 1555273_at (Homo sapiens, Affymetrix Probeset): bone marrow plasma cell, plasma cell, orbital adipose tissue, lacrimal gland, liver-infiltrating lymphocyte, spinal cord neuron (unspecified), pars reticulata, tonsillar CD8 resting T-cell (unspecified), Brodmann area 10, lateral thalamic nucleus
Orbital trauma or any trauma or injury around the eyes should be thoroughly assessed and, if necessary, treated by an oculoplastic surgeon.
And then something kinda slowly happened. After all, you do get brainwashed training at the same institution for six years. And not that I consider myself a brilliant researcher, but at least I learnt some of the ropes. I learnt what it takes to write a paper, analyze a study, even perform experiments (I got to play with human orbital fibroblasts, yay!). And I popped my publication cherry. And became a scientist. I still consider myself one- after all, a doctor is a person of science, and as dynamic as science can be, we too need to evolve and learn, dont we? And so, its interesting how I went from that hater of EBM in 1999, to one who looks at The Evidence, to guide his clinical judgments. Not only the conclusions of the study, but also to try to pick apart the study to see if he agrees with the findings. After all, the goal of an author is to get the study published, and one often learns to present the data in the most compelling way; so you cant always take things at face value. And so, ...
Orbital penetrating injuries may cause significant harm to optic nerves and eyeball as well as to the brain and cerebral vasculature. Defining surrounding neurovascular structures by CT angiography (CTA) is important for surgical removal. We present an uncommon case of a 3-year-old child with a penetrating orbital injury caused by a toothbrush. To the best of our knowledge, there is no report orbital injury with a toothbrush so far. ...
Q: Dr. Eppley, Im a 32 year old man. I want a customized implant to provide forward projection to my infraorbital rims. Uniquely, I want this implant to move the frontal process of the maxilla forward. Here, I am referring to the point at which the infraorbital rim meets the frontal process. This would typically be a portion of the face moved by the Le Fort 2 osteotomy. I want to raise my infraorbital margin too. I want this implant to extend onto the zygomatic arch to provide a small amount of lateral projection there. I want no lateral movement of the zygomatic body, because I dislike cheekbone mass. The key objective for me however, is to widen the perceived appearance of my orbital complex. Ive noticed that this is an under appreciated and core aspect of beauty that most male models possess. I believe that this is possible by widening the brow bone, the lateral orbital rim and the zygomatic arch. I have so many questions on the theory of this, but I will limit them to 4 questions for your ...
Volume rendering evaluation of bony orbital walls before and after surgical decompression. -- Volume rendering reconstructions showing the lateral (greater wing of the sphenoid ...
As the ophthalmic division (V1) of the trigeminal nerve enters the orbit via the superior orbital fissure, it divides into three branches: the frontal nerve, the nasociliary nerve, and the lacrimal nerve. The supratrochlear nerve and the supraorbital nerve are branches of the frontal nerve. Links and References: ...
BACKGROUND: Lateral canthal rhytides partly result from repetitive muscular actions of the orbicularis oculi. OBJECTIVE: To determine the efficacy of one versus three injection sites of AbobotulinumtoxinA (ABO) in the treatment of lateral canthal rhytides. METHODS: This was a two-center, evaluator-masked, 120 day study in which 40 patients with moderate to severe hyperdynamic lateral canthal rhytides at maximal contracture were randomized to receive one injection of 36 Units of ABO into the middle of the lateral orbital rhytides on one side, with the contralateral side treated with the same total dose of ABO, divided into three intradermal injections of 12 Units each, along the lateral canthal area. A blinded evaluator assessed lateral orbital rhytides at rest and maximal contraction at baseline, 7, 42, 90, and 120 days post treatment. Standardized digital photography and subject self- assessment were performed at each visit. RESULTS: No statistically significant difference was seen at any visit
ENDOSCOPIC ORBITAL AND TRANSORBITAL APPROACHES Authors: Iacopo DALLAN, MD 1,6 Paolo CASTELNUOVO, MD 2,6 Stefano SELLARI-FRANCESCHINI, MD 1 With contributions of: Davide LOCATELLI, MD 3,6 Co-Authors: Mario
Scientists from the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI) in Berlin combined state-of-the-art experiments and numerical simulations to test a fundamental assumption underlying strong-field physics. Their results refine our understanding of strong-field processes such as high harmonic generation (HHG) and laser-induced electron diffraction (LIED). Strong infrared laser pulses can extract an electron from a molecule (ionization), accelerate it away into free space, then turn it around (propagation), and finally collide it with the molecule (recollision). This is the widely used three-step model of strong-field physics. In the recollision step, the electron may, for example, recombine with the parent ion, giving rise to high harmonic generation, or scatter elastically, giving rise to laser-induced electron diffraction. One of the commonly used assumptions underlying attosecond physics is that, in the propagation step, the initial structure of the ionized electron is
There is no difference between the sexes when it comes to an exaggerated temporal fossa depression. Even though I have treated only one woman with a significant indentation, I believe strongly that a deeply concave or inwardly curved space has nothing to do with gender. Whether you are a man or a woman, a pronounced hollow just behind your lateral orbital rims, the bony ridges to the side of your eyes, can have a significant effect on your facial aesthetics. This hollow can make you appear starving when you are well fed. Although the majority of the people dont have a temporal fossa depression that merits attention, it is not an uncommon occurrence. ...
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G. eвf Coronal and sagittal, thin MPRs allow for localization of the fistula site (arrow) at the level of the superior orbital fissure (SOF).
IOF: How has your involvement with IOF impacted you the most?. Dr. Kramberg: IOF has provided a springboard to share techniques and outcomes with my fellow practitioners.. IOF: What do you treat most frequently?. Dr. Kramberg: The patient that I treat most frequently is the orthopedic knee patient that has been told that he or she needs surgery. Some surgeons simply ask, When do you want to schedule the surgery? without offering alternatives. The reward for me is seeing the patient return to an active, pain free life.. IOF: What are you most proud of in your practice?. Dr. Kramberg: I am most proud of the strides we have made in patient care, evaluations, and treatment. I appreciate receiving positive feedback from patients I have treated, as well as referrals from other providers in the field.. IOF: Where do you see the field of regenerative medicine going in the next 5 years?. Dr. Kramberg: In the next 5 years I expect Interventional Orthopedics to be the first choice of care for educated ...
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Let me just start with with.... I am in a very weird situation because this is a problem that i should have dealt with a long time ago. I am very worried about my eye and psychological health. I have...
On the left images of a patient with an orbital varix, who had noticed that during straining there was a propulsion of the left eye . The upper image is during rest and the lower image is during valsalva at the moment of sneezing. During valsalva the varix shows extreme dilation (red arrow). Notice that during valsalva also on the normal side the superior ophthalmic vein dilates (blue arrow).. ...
Potts, A.W.; Price, W.C., Photoelectron spectra and valence shell orbital structures of groups V VI hydrides, Proc. R. Soc. London A:, 1972, 326, 181. 16 matching species were found. For each matching species the following will be displayed: ...
PHACON developed in close cooperation with experienced specialists and ENT specialists at the Medical College in Hannover a PHACON Orbit System. The System is designed specifically for the pointed orbital floor fracturing and surgical reconstruction. Based on high resolution real CT-data of patients, the new PHACON Orbit System presents the simulation of transconjuctival approach to orbital cavity ...
The investigators will measure fetal orbital transverse and anterior-posterior diameter by 2D ultrasound and orbital volume by 3D ultrasound in women visiting our unit for other examinations during pregnancy. The investigators will examine 5-10 women in each gestational age in order to create a normal values curve throughout pregnancy ...
4. Secondary to diseases of the nose and the bony air sinuses around the orbital cavities. As most of the eye specialists in this country and also of Great Britain whom we generally follow make special study of the diseases of the eye alone, they very often overlook this aspect of the watering of the eyes and fail to give relief to their patients by the usual eye drops. The Americans who are the most practical nation in the world have realised its importance long ago and in America the specialists always combine ophthalmic knowledge with the specialised knowledge of the diseases of the ear, nose and throat ...
Motor vehicle and bicycle accidents are the most common causes of blunt head trauma. Other common etiologies are falls, physical violence, and sports accidents. Blunt trauma toward the superior orbital rim, lateral orbital rim, frontal region, and cranium may lead to intraorbital hematoma. A fracture following the blunt head trauma may form a one-way valve, which leads to orbital emphysema and a more pronounced increase in orbital pressure. Increased tissue pressure in an enclosed space will eventually lead to an inevitable decrease in tissue perfusion. It is important to treat the patient within the first 48 hours following the trauma, which is accepted as the critical period. In this report we present a case involving a 42-year-old man who was admitted to our clinic with left periorbital pain, edema, proptosis, and blurred vision after experiencing physical violence. The medical history and physical examination findings, along with imaging studies and a description of the endoscopic orbital ...
The pathogenesis of orbital Graves disease (GD), a process known as thyroid-associated ophthalmopathy (TAO), remains incompletely understood. The thyrotropin receptor (TSHR) represents the central autoantigen involved in GD and has been proposed as the thyroid antigen shared with the orbit that could explain the infiltration of immune cells into tissues surrounding the eye. Another cell surface protein, insulin-like growth factor-I receptor (IGF-IR), has recently been proposed as a second antigen that participates in TAO by virtue of its interactions with anti-IGF-IR antibodies generated in GD, its apparent physical and functional complex formation with TSHR, and its necessary involvement in TSHR post-receptor signaling. The proposal that IGF-IR is involved in TAO has provoked substantial debate. Furthermore, several studies from different laboratory groups, each using different experimental models, have yielded conflicting results. In this article, we attempt to summarize the biological
TY - JOUR. T1 - Cavernous haemangioma in the orbital apex. T2 - Stereotactic-guided transcranial cryoextraction. AU - Papalkar, Daya. AU - Francis, Ian C.. AU - Stoodley, Marcus. AU - Kaines, Andrew. AU - Sharma, Shanel. AU - Kalapesi, Freny B.. AU - Wilcsek, Geoffrey A.. PY - 2005/8. Y1 - 2005/8. N2 - A 55-year-old Caucasian woman presented with an orbital cavernous haemangioma superior to the optic nerve in the orbital apex. Preoperative imaging demonstrated a mass involving the superomedial and superolateral quadrants of the posterior orbit. A stereotactic fronto-orbital approach was performed by the neurosurgical team, and cryoextraction of the lesion was accomplished by the ocular plastic surgical team.. AB - A 55-year-old Caucasian woman presented with an orbital cavernous haemangioma superior to the optic nerve in the orbital apex. Preoperative imaging demonstrated a mass involving the superomedial and superolateral quadrants of the posterior orbit. A stereotactic fronto-orbital approach ...
Penetrating orbital injuries pose a serious threat to vision, ocular motility, and in some cases, life. Long, sharp stiletto objects may penetrate deeply, causing catastrophic damage to orbital structures, despite seemingly trivial entry wounds. The authors present two cases of penetrating orbital injuries by stiletto objects, both entering via small eyelid wounds. Traumatic optic neuropathy occurred in both cases, and was treated with corticosteroids, however the globes escaped direct injury. Injuries to the IIIrd and VIth cranial nerves were also observed. Deep orbital injuries must be excluded in patients presenting with small eyelid wounds caused by sharp penetrating objects.. ...
We previously described a significant response to RTX treatment in patients with active TAO, with no effect on TRAb and hyperthyroidism. In order to study the effect of RTX in the orbit, we analyzed the orbital tissues of 9 patients with TAO at decompression after RTX (n.2) or other treatments. Decompression was carried out in 2 patients for sight threatening optic neuropathy and in 7 for correction of proptosis. Of the RTX treated patients, one was decompressed after 12 months because of optic neuropathy, while the other after 23 months with burnt out disease. Of the other 7 patients, one was decompressed for the second time because of relapse of optic neuropathy that did not respond to steroids and 6 had burnt out disease of 15-175 months of duration. Immunohistochemistry of orbital fat and muscle showed presence of infiltrating immune cells in all patients. Infiltrates were present independently of the duration and the type of treatment of TAO and of thyroid disease. Interestingly, in the ...
TY - JOUR. T1 - The paradoxical predominance of medial wall injuries in blowout fracture. AU - Choi, Kwang Eon. AU - Lee, Joonsik. AU - Lee, Hwa. AU - Chang, Minwook. AU - Park, Minsoo. AU - Baek, Se Hyun. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Purpose: To evaluate the type and cause of orbital blowout fractures in Korea. Design: Retrospective, observational case series. Methods: Patients who underwent reconstruction for blowout fracture from March 2004 to April 2013 at Korea University Guro and Ansan Hospitals were included in this study. Patient demographics and orbital computed tomography (CT) scans were reviewed. On CT, ethmoid air cell septa, blowout fracture type, and other combined fractures were analyzed. Blowout fracture was classified as affecting up to 4 areas: the floor lateral to the infraorbital canal, the floor medial to the canal, the maxilla-ethmoidal strut (inferomedial strut), and the medial wall. Furthermore, trauma type and associated injury were reviewed. The results of ...
M. Morinaga, in Titanium in Medical and Dental Applications, 2018. Molecular and Electronic Structure of Hydronium Ion 22 What about the O-atom when it has only a single lone pair, in case such as hydronium? Click hereð to get an answer to your question ï¸ Explain the molecular orbital structure of benzene? Printed in the Netherlands CNDO/2 MOLECULAR ORBITAL CALCULATION OF THE DEWAR STRUCTURE OF BENZENE ZDZIS3E-AW LATAJKA AND HENRYK RATAJCZAK Institute of Chemistry, University of Wroclaw, Wroclaw (Poland) W. J. ORVILLE-THOMAS Department of Chemistry and Applied Chemistry, University of Sal â ¦ Abstract. ... Each atom in the ring must have an unhybridized p-orbital. The molecular structure of benzene derivatives, part 2: 4-chloro-benzaldehyde by joint analysis of gas electron diffraction, microwave spectroscopy and ab initio molecular orbital calculations. The curly arrows represent the migration of Pi electrons. Figure 1 serves to illustrate the above point. Do you notice something missing, ...
title: MicroRNA-27 inhibits adipogenic differentiation in orbital fibroblasts from patients with Graves orbitopathy, doi: 10.1371/journal.pone.0221077, category: Article
We explain what thyroid-associated orbitopathy is. The causes and symptoms of this pathology. ✅ Specialised treatment at Barraquer.
Intraorbital haematoma is a rare clinical entity which can be caused by orbital traumas, neoplasms, surgeries nearby sinuses and orbit, vascular malformations, acute sinusitis, systemic abnormalities, barotrauma and valsalva maneuver. A 74-year-old male presented with sudden onset of ocular pain, upper eye lid swelling, proptosis and diplopia after a commercial flight. After complete ophthalmic ocular examination including pupillary light reflexes and laboratory examinations; computed tomography and magnetic resonance imaging of orbit revealed a subperiostal mass-like lesion in the right retrobulbar-extraconal region which was compatible with intraorbital haematoma. Visual acuity was not compromised so we planned a conservative approach with close observation. We administered systemic corticosteroid and topical dorzolamide/timolol combination therapy. At the first month follow-up, intraorbital haematoma resolved without significant sequelae. Intraorbital haematoma can be managed by conservative approach
Purpose. Graves ophthalmopathy (GO) is characterized by the infiltration of immune cells into the orbit, a process in which cytokines play a central role. Orbital fibroblasts are potent producers of cytokines on different stimuli. Recently, the authors showed increased expression of the PDGF-B chain in GO orbital tissue. The dimeric PDGF-BB molecule has been described to activate the NF-κB pathway, which is well recognized for its role in regulating cytokine production. This study was conducted to determine the role of PDGF-BB in the production of proinflammatory cytokines by orbital fibroblasts in GO. Methods. Orbital, lung, and skin fibroblasts were stimulated with PDGF-BB, and cytokine (IL-1β, IL-6, IL-8, IL-16, CCL2, CCL5, CCL7, TNF-α) production was measured by ELISA. Involvement of NF-κB activation through PDGF signaling was investigated by electrophoretic mobility shift assay, specific NF-κB inhibitors, and the PDGF-receptor kinase inhibitor imatinib mesylate. Results. IL-6, IL-8, ...
80 As we have seen earlier, structures like linear, tetrahedral etc, can be obtained on the basis of bond angle. Benzene and derivatives 1. 1. In benzene, the carbon atoms are sp2 hybridized. Naively, the molecule as shown can be determined to have chemical formula C 6H 6. The resonance energy of benzene is about 150.6 kJ mol-1, i.e. ... Each atom in the ring must have an unhybridized p-orbital. (b) The electrons in the resulting p molecular orbitals are delocalized over the entire ring of carbon atoms, giving six equivalent bonds. The energy of the upper orbital is greater than that of the 1s atomic orbital, and such an orbital is called an antibonding molecular orbital. The linear combination of atomic orbitals or LCAO approximation for molecular orbitals was introduced in 1929 by Sir John Lennard-Jones. molecular structure and characteristic molecular orbital map. Structure of Benzene. â ¢ The Ï -electrons are disregarded, except for their role in establishing the molecular geometry. ...
However, we find that the incidence of injury is significantly higher in the pure fracture group suggesting that a different mechanism is at play. It is more reasonable to envision that the acute rise in orbital pressure would lead not only to the floor fracturing, but also to a greater incidence of intraocular injury as the globe retropulses. One could argue, however, that in the case of the impure fracture, the rate of injury is lower because the force is blunted by the rim. Nevertheless, we believe that these data suggest that the retropulsion theory might possibly be the more likely explanation for orbital fractures; one theory (retropulsion) can explain variations of ocular findings in both pure and impure fractures ...
The researchers found that in the intention-to-treat population, 69 and 20% of those who received teprotumumab and placebo, respectively, had a response at week 24.
By Chris Williams: Naoya Monster Inoue reportedly suffered a fractured right orbital bone in his victory over WBA bantamweight champion Nonito Donaire
A systemic radiological approach to examining the images is needed to reach a differential diagnosis. The images should be studied for lesion appearance, localization, contrast enhancement, bony orbit evaluation, and detection of calcifications.[3,4]. The lesion appearance on imaging includes; solid or cystic, well circumscribed or ill-defined, and localized or infiltrative.[4] Comparing the density of the lesion with that of the vitreous body can help to identify a solid lesion, whose density is higher than that of vitreous on CT images.[4]. Orbital tumors can be localized anatomically to within the globe/intraocular or intraconal or in the extraconal space, the orbital apex, the extraocular muscles, or the lacrimal gland. CT remains the modality of choice for evaluation of the bony orbit and paranasal sinuses. MRI is preferred to evaluate the optic nerve and chiasm.[3,4]. Contrast enhancement aids in the characterization of orbital masses. Moderate to marked enhancement is usually noted in ...
Today, the U.S. Food and Drug Administration (FDA) approved Tepezza (teprotumumab-trbw) for the treatment of adults with thyroid eye disease, a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to be pushed forward and bulge outwards (proptosis). Todays approval represents the first drug approved for the treatment of thyroid eye disease.. Todays approval marks an important milestone for the treatment of thyroid eye disease. Currently, there are very limited treatment options for this potentially debilitating disease. This treatment has the potential to alter the course of the disease, potentially sparing patients from needing multiple invasive surgeries by providing an alternative, non surgical treatment option, said Wiley Chambers, M.D., deputy director of the Division of Transplant and Ophthalmology Products in the FDAs Center for Drug Evaluation and Research. Additionally, thyroid eye disease is a rare disease that impacts a small ...
Enophthalmos is the posterior displacement of the eyeball within the orbit due to changes in the volume of the orbit (bone) relative to its contents (the eyeball and orbital fat), or loss of function of the orbitalis muscle. It should not be confused with its opposite, exophthalmos, which is the anterior displacement of the eye. ...
Results Eleven orbits of six patients (five females) with a median age of 57 years (range 23-65) were included in this study. Temple-related problems consisted of cosmetically bothersome temple hollowness (n=11; 100%), masticatory oscillopsia (n=8; 73%), temple tenderness (n=4; 36%), clicking sensation (n=4; 36%) and gaze-evoked ocular pain (n=4; 36%). Nine orbits were also complicated by proptosis and exposure keratopathy. Preoperative imaging studies showed the absence of lateral wall in all 11 orbits and evidence of prolapsed lacrimal gland into the wall defect in four orbits. Intervention included the repair of the lateral wall defect with a sheet implant, orbital decompression involving fat, the medial wall or orbital floor and autologous fat transfer or synthetic filler for temple hollowness. Postoperatively, there was full resolution of masticatory oscillation, temple tenderness, clicking sensation and gaze-evoked ocular pain, and an improvement in temple hollowness. Pre-existing ...
Folia Histochemica et Cytobiologica (FHC) is an international,English-language journal devoted to the developing fields of histochemistry,cytochemistry,cell biology,cell and tissue biology.It is source of the recent research in fields of and cell biology
Thyroid eye disease (TED) causes the muscles and soft tissues in your eye socket to swell. It is also known as thyroid associated ophthalmopathy, thyroid orbitopathy, Graves orbitopathy or Graves ophthalmopathy.
The U.S. Food and Drug Administration (FDA) approved Tepezza (teprotumumab-trbw) for the treatment of adults with thyroid eye disease, a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to be pushed forward and bulge outwards (proptosis). Today s approval represents the first drug approved for the treatment of thyroid eye disease. Today s approval marks an important milestone for the treatment of thyroid eye disease. Currently, there are...
Define infraorbital fold. infraorbital fold synonyms, infraorbital fold pronunciation, infraorbital fold translation, English dictionary definition of infraorbital fold. fold1 top: isocline fold center: overturned fold bottom: recumbent fold v. fold·ed , fold·ing , folds v. tr. 1. To bend over or double up so that one part...
The inferior rectus (also inferior rectus muscle, inferior rectus extraocular muscle, latin: musculus rectus inferior) is one of the six extra-ocular muscles that are in control of eye movements.
The optic nerve within the optic canal, the parophthalmic segment of the carotid artery, and the oculomotor nerve in the superior orbital fissure all lay a
Bilateral subfrontal gives much better access than unilateral. The blind spot behind ipsilateral optic nerve can be visualised from the contralateral side. I never use unilateral approach. Head extended so that frontal lobes fall back by gravity. Do not use lumbar drain because much higher chance of extradural hematoma because frontal lobe often sunken at the end of surgery with drainage of CSF.. Bicoronal curvy incision results in better hair growth than straight one. Skin incision does not need to go all the way down to zygomatic arches unless pterygonal approach is needed as well. In that case head is tilted slightly toward that side. Harvest pericranium for repair using wet gauze to wipe the pericranium off the bone. Temporalis fascia may be harvested toward end of operation if needed for dural repair. Burr holes are made either above lateral orbital rim or behind depending on the amount of exposure needed. Use a long cutting blade to reach near midline and crack the middle.. Alternatively, ...
Its terminal branches, escaping from the gland, are distributed to the eyelids and conjunctiva: of those supplying the eyelids, two are of considerable size and are named the lateral palpebral arteries; they run medially in the upper and lower lids respectively and anastomose with the medial palpebral arteries, forming an arterial circle in this situation. The lacrimal artery also give off one or two zygomatic branches, one of which passes through the zygomatico-temporal foramen, to reach the temporal fossa, and anastomoses with the deep temporal arteries; another appears on the cheek through the zygomatico-facial foramen, and anastomoses with the transverse facial. A recurrent branch passes backward through the lateral part of the superior orbital fissure to the dura mater, and anastomoses with a branch of the middle meningeal artery. ...
The second day of the course will include didactic sessions covering modern understanding of orbital disease and advanced techniques for management. The faculty consists of experts in the area of orbital disease and treatment who will share their knowledge and experience with participants. A range of high yield topics will be covered including orbital trauma, vascular lesions, tumors, inflammatory disease and thyroid-related orbitopathy. Complex cases presented by participants will be discussed by expert panel members in an interactive manner. Individuals unable to participate in the first day dissection course will be welcome to attend. Target Audience: This course is targeted to practicing ophthalmologists and orbital surgeons. For more information visit the CME web site . ...
This report describes the anatomy of the frontal branch of the seventh nerve and a technique for assuring its preservation when doing a low frontal approach. By dissecting under both layers of the temporal fascia, rapid and safe access to the inferior fronto-orbital region may be achieved. This technique is recommended for exposure of a bony lesion in the fronto-orbital region and when performing an osteoplastic pterional craniotomy.
Orbital Tumors Stockton - Central Valley Eye Medical Group offers treatment for Orbital Tumors. Our office serves Stockton, Manteca CA and surrounding areas
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Over the last 4 years I have primarily utilized a temporal endoscopic plane approach (between the superficial and deep temporalis fascia) with or without the use of the endoscope to reshape the brow contour. My focus has been a temporal lift only. In my experience, in most cases, lifting the medial brow is an error which changes normal eyelid and periorbital, and ultimately, facial proportions. Most who need medial brow elevation also have bunching of glabellar tissue, and I have found benefit most from a central pretrichial approach (with tissue excision) combined with the temporal lift described below.. The procedure proceeds with standard temporal approach sub-superficial temporal fascia access to the canthus. This plane is made continuous with the central subperiosteal space by dividing the conjoint tendon. Dissection continues to the arcus marginalis periosteum at the superior orbital rim. The periosteum is released from the supraorbital neurovascular bundle laterally to the canthus. It is ...
7. propanolol b ппппa the gland to the periosteum of the superior orbital rim during blepharoplasty can improve the surgical result without compromising tear production (Fig.
Thyroid Eye Disease Your doctor thinks you have thyroid orbitopathy. This is an autoimmune condition where your bodys immune system is producing factors that stimulate enlargement of the muscles that
Treatment is essential to protect the cornea and the optic nerve from getting permanently damaged. In the initial stages of the disease, lubricating drops are used to keep the eye moist. Most patients must be started on steroid tablets for a few months to control the progression of the disease. Closure of the lids may be required if the lids are not able to completely cover the eyes. The closure is temporary and is done only on the outer part of the lids, leaving the cornea clear so that vision is not affected. If protrusion of the eyeball is too great the optic nerve is in danger. At this stage, orbital decompression is advised. This surgery involves breaking one or more walls of the orbit in order that the extra fat, which has been deposited in the orbit due to thyroid eye disease, may be displaced out of the orbit. The eyeball can then be pushed back into the orbit. A patient who has suffered from thyroid eye disease for a long time develops eye movement disorders and requires eye muscle ...
The doctors at Eyesthetica also perform bony decompression surgery for thyroid eye disease, where the bones of the orbit are reshaped to protect the eye, restore the previous appearance, and protect the vision. Call at 213-234-1000 for more information.
• Seven cases of subcutaneous epithelioid granulomas caused by silica and involving the eyelids and periorbital region are described. Histologically, all cases
Intra-individual consistency of lymphocyte re- sponses to the in vitro suppressive effect of steroid. 32a shows the characteristic function for the sets A, B, and C. Define the facial skin redundancy Absent Moderate Marked The hairline is Normally positioned Too high Too low The forehead profile is Flat Round Presence of inferior cymbalta sleepy all the time (clear definite orbital bar) Cymbalta sleepy all the time supraorbital bar is Normally shaped Protruding Recessive Forehead transverse lines Just visible Moderate Marked Vertical frown lines Te lines) Absent Moderate Marked Horizontal frown line (nasal radix line) Absent Moderate Marked Temporal depression Absent Moderate Marked Does the orbital region look cmybalta. This process will be s leepy below and will be modeled, in large part, after a 30-year-old comparative brand-name evaluation program and processes used by ECRI to advise hospitals on medical device selection.
the superior half of the orbital rim, which constitutes the curved superior border of the orbital opening, formed by the frontal bone. [ http://www.medilexicon.com/medicaldictionary.php?t=52809 ...
NO. 1 GARTH AND STEPHENSON : PORTUNIDAE 61 Carapace hexagonal, only moderately broad, fairly convex, and bearing the following ridges: mesogastrics, metagastrics, and epibranchials (plus others different in the two species) ; postlateral corner smoothly rounded. Front four-toothed (considering process lateral to the four teeth as inner subdivision of inner supraorbital angle), teeth of approximately equal size, deeply separated from inner supraorbital angles. Orbital region with inner supraorbital angles clearly subdivided into a narrower, sharper inner lobe and a broader, blunter outer lobe; two supraorbital fissures, and a deep suborbital fissure with a distinct lateral tooth; main suborbital tooth well developed. Anterolateral teeth: first live teeth alternately large and small. Third maxillipeds with a slight production of the anteroexternal angle of the merus. Chelipeds massive; anterior border of arm with massive spines; wrist with inner spine strong and three spines or spinules on outer ...
During your consultation, you will learn about the Orthognathic Surgery treatment plan and discuss your needs and concerns. Seeing a patient with extensive deformities of the face, jaws, and teeth requires a systematic evaluation. Dr. Srikanth Yadav Puligilla will carefully examine your proportion of your entire face the orbital region, as well as the nose, lips, and mouth, which must all be evaluated. In addition, functional problems with the bite problems with dental hygiene such as the recession of gums, abnormalities of the teeth, and functional compromise of the airway, such as sleep apnea. The face is analyzed clinically and cephlometrically. In the profile view, the clinical and cephalometric examinations analyze the face anteroposteriorly. The frontal clinical view is responsible for revealing midlines, cants, yaw, and outline of the face. After that, he will determine what type of treatment you need to best maximize your result. Computerized facial imaging may be recommended to assess ...
Adult male.-Above metallic golden or bronzy green, the upper tail-coverts mostly cinnamon-rufous basally and laterally; rectrices cinnamon-rufous, the middle pair with a broad, fusiform mesial stripe of purplish black, extending for nearly the entire length, the next two (on each side) with a similar but broader and more cuneate stripe, the two outer pairs (on each side) with outer web and part of inner web purplish black; remiges purplish dusks, the inner secondaries glossed with bronze-green, the primary coverts similar in color to primaries but darker; loral and orbital regions deep cinnamon-rufous; chin and throat (gorget) brilliant metallic orange-red or orange (less scarlet than in S. rufus and S. [sasin]), changing to golden green in position d; chest dull white, tinged with cinnamon-buff posteriorly, the feathers dusky gray beneath surface; rest of under parts pale cinnamon-rufous or cinnamon-buff, paler medially, the sides (especially sides of breast) spotted with metallic bronze-green; ...
In this discussion from the Academys Committee on Aging, Drs. Andrew Lee and Neil Miller discuss how to manage thyroid eye disease in elderly patients.
Significantly, Anoiapithecus also exhibits the basic facial hominid synapomorphies (8), indicating that this taxon is a stem member of the great ape and human clade: high face, high zygomatic root, pyriform nasal aperture widest at the base, deep palate, and nasals that project slightly anteriorly beneath the level of the lower orbital rims (observed from the nasomaxillary sutures). The same modern facial pattern is also shared by Pierolapithecus (5), despite the striking differences in facial profile as compared to Anoiapithecus.. The retention of highly specialized, derived kenyapithecine features in a stem hominid such as Anoiapithecus has important implications for understanding the origin of the Hominidae. The presence in Eurasia of kenyapithecin hominoids (Kenyapithecus and Griphopithecus) of putative African origin by ≈16.5 Ma (18) or 15-14 Ma (19, 20) has led some authors to hypothesize that later Middle and Late Miocene Eurasian hominids evolved from these taxa (2, 7, 8, 10, 16, ...