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TY - JOUR. T1 - Inhibitory effect of ondansetron on glycine response of dissociated rat hippocampal neurons. AU - Ye, Jiang Hong. AU - Schaefer, Rebecca. AU - Wu, Wen Hsien. AU - Liu, Philip L.. AU - Zbuzek, Vlasta K.. AU - McArdle, Joseph J.. PY - 1999/7/1. Y1 - 1999/7/1. N2 - We examined the effect of ondansetron, an antagonist of type 3 serotonin receptors, on the whole cell response of freshly isolated hippocampal CA1 pyramidal neurons of neonatal and mature rats to glycine using the gramicidin perforated patch technique. Ondansetron depressed the current induced by subsaturating concentrations of glycine (I(Gly)) in a concentration-dependent manner. The ondansetron concentration needed to depress I(Gly) induced by 30 μM glycine to half amplitude was 25 μM. Ondansetron (54 μM) shifted the glycine concentration-response curve to the right in a parallel manner, increasing the EC50 for glycine from 40 ± 3 μM to 70 ± 5 μM. Ondansetron increased the time constant of activation of I(Gly) ...
Ondansetron was first approved in 1991 for treatment of nausea and vomiting associated with chemotherapy and surgical procedures and as ondansetron was developed prior to current regulatory requirements, a formal, thorough QT study has not been performed for this compound. The purpose of this study is to further define the safety of ondansetron as some effects on QT interval prolongation have been observed for this and other members of the 5-HT3 inhibitor class of compounds. In the case of ondansetron, these effects have been rare and transient and noted primarily with IV administration, however, the extent to which ondansetron prolongs the QT interval has not been defined.. This study will quantify the effects of a single dose of IV ondansetron administered over 15 minutes on cardiac conduction in a double-blind, cross-over study and compared to placebo and a positive control, oral moxifloxacin. Pre- and post-dose digital electrocardiograms (ECGs) will be obtained by continuous Holter ...
QUESTION. While I usually prescribe doxylamine-pyridoxine for morning sickness, some of my patients with severe nausea and vomiting of pregnancy (NVP) receive ondansetron in hospital. I have read some new precautions recommended by the US Food and Drug Administration (FDA). Is ondansetron safe to use during pregnancy?. ANSWER. During the past decade ondansetron has been increasingly used in the United States for NVP, owing to the lack of an FDA-approved drug for this condition. While fetal safety data for doxylamine-pyridoxine are based on more than a quarter of a million pregnancies, the fetal safety data for ondansetron are based on fewer than 200 births. Moreover, a recent case-control study suggested there was an increased risk of cleft palate associated with ondansetron. Recently, the FDA issued a warning about potentially serious QT prolongation and torsade de pointes associated with ondansetron use; the warning included a list of precautions and tests that must be followed. The drug is ...
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I ondansetron anaphylaxis expect hives, like an allergic reaction, just itching and redness The one time that does not concern me about using with lexapro, is that you can ondansetron anaphylaxis with wellbutrin and it ondansetron anaphylaxis not feeling more anxiety, so Ive heard Suddenly Recycled Itching. Could the itching be due to go up anxiety. If so, it might go away the longer Im on it. Qualifications anyone know of an ad that comes like lexapro. My dr. wont prescibe paxil. To date, all anaphylaxis and anaphylactoid reactions induced by ondansetron have been in patients receiving the drug for cancer chemotherapy. This has prompted some authors to suggest that the drugs use should be restricted [6]. In the Indian market, the drugs have a wide availability with over 43 ‎Abstract · ‎Introduction · ‎Case presentation · ‎Discussion. Ondansetron is a selective serotonin receptor (5-HT3) antagonist that is widely used as an antiemetic agent for highly, and now increasingly for ...
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Background and objective: Ondansetron is widely used for the prophylaxis of postoperative nausea and vomiting, while haloperidol is an antiemetic that lacks recent data on efficacy and adverse effects. Methods: In this prospective, randomized, double-blinded study involving 93 females undergoing gynaecological procedures under general anaesthesia, we compared the efficacy and adverse effects of prophylactic haloperidol 1 mg intravenous and ondansetron 4 mg intravenous vs. placebo. Results: During the overall observation period (0-24 h), in the haloperidol, ondansetron and placebo groups respectively, the incidence of nausea and-or vomiting was 40.7percent (11-27), 48.2percent (13-27) and 55.5percent (15-27), and the need of rescue antiemetics was 22.2percent (6-27), 44.4percent (12-27) and 40.7percent (11-27), with P values 0.05 among the three groups. During the early observation period (0-2 h), in the haloperidol, ondansetron and placebo groups respectively, the incidence of nausea and-or ...
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This trial compared the efficacy and tolerability of oral ondansetron + dexamethasone alone or in combination with aprepitant [MK 869, aprepitant] for the
As part of a three-drug regimen, APF530 (extended-release formulation of granisetron) has become the first 5-HT3 (5-hydroxytryptamine) receptor antagonist to demonstrate superiority over the standard of care for delayed nausea and vomiting after highly emetogenic chemotherapy. According to the results of the MAGIC trial, presented at the 2015 Breast Cancer Symposium, APF530, administered with fosaprepitant (Emend) and dexamethasone, provided superior complete response in delayed-phase chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy vs a standard-of-care regimen of ondansetron with fosaprepitant plus dexamethasone.1. "The APF530 regimen was associated with a clinical benefit over the ondansetron regimen in nausea control, rescue medication use, and patient satisfaction," said Ian D. Schnadig, MD, of Compass Oncology, US Oncology Research, Tualatin, Oregon. "It is significant that both arms of the study had a three-drug prophylactic regimen, which has not been ...
This study will investigate the effects of ondansetron on haemodynamics in female patients undergoing elective caesarean deliveries under spinal anaesthesia.
The goal of this clinical research study is to compare the effectiveness of receiving a combination of ondansetron and aprepitant to receiving ondansetron alone in helping to prevent nausea and/or vomiting in patients with AML or HR-MDS who are receiving cytarabine. The safety of this drug combination will also be studied.
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Severe nausea and/or vomiting in patients receiving radiotherapy to the upper abdomen is common despite having received pre-medication with ondansetron, a standard preventive treatment. This study aims to reduce the incidence of significant nausea and/or vomiting with the addition of the NK1-antagonist aprepitant to standard ondansetron treatment. This study will also assess the safety and tolerability of prolonged administration of aprepitant over the 4 to 6 week period of radiation treatment ...
Risk Summary Available data do not reliably inform the association of ondansetron and adverse fetal outcomes. Published epidemiological studies on the association between ondansetron and fetal outcomes have reported inconsistent findings and have important methodological limitations hindering interpretation [see Data]. Reproductive studies in rats and rabbits did not show evidence of harm to the fetus when ondansetron was administered intravenously during organogenesis at approximately 3.6 and 2.9 times the maximum recommended human intravenous dose of 0.15 mg/kg given three times a day, based on body surface area, respectively [see Data].. The background risk of major birth defects and miscarriage for the indicated population is unknown. In the US general population, the estimated background risk of major birth defects and miscarriages in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. Data Human Data Methodological limitations of the epidemiology studies preclude a ...
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Zofran (Ondansetron) - Side Effects, Dosage, Interactions - Drugs ODT, do not remove the tablet from its foil pocket until just before you take it. You should not take Zofran if you take a drug called apomorphine, which is an injectable drug used to treat Parkinson 39;s disease. The combination of apomorphine and ondansetron can cause dangerously low blood pressure. ZOFRAN 4MG TABLETS tablets. Other medicines and Zofran Please tell your doctor, nurse or pharmacist if you are taking or have recently taken or might take other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Zofran can affect the way some nbsp; Zofran Dosage Guide - (ondansetron hydrochloride). Includes dose adjustments, warnings and precautions. Zofran: Dosage, Side Effects amp; Pregnancy - Live Science Adults typically take one 8-mg tablet or rapidly disintegrating tablet or 10 mL of liquid twice a day. For patients ages 12 and older, the dosage is the same as for ...
Buy Zofran is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.. Zofran (Ondansetron 4/8mg) $1.50 pill - Gastrointestinal Tract @ Achat Medicament En Suisse En ligne - Sans Ordonnance. Acheter Medicament Sans Ordonnance en ligne en Suisse, en France, en Belgique.
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TY - JOUR. T1 - The delayed-emesis syndrome from cisplatin. T2 - Phase III evaluation of ondansetron versus placebo. AU - Gandara, David R. AU - Harvey, Walter H.. AU - Monaghan, Gregory G.. AU - Perez, Edith A.. AU - Stokes, Cathy. AU - Bryson, Judy C.. AU - Finn, Andrew L.. AU - Hesketh, Paul J.. PY - 1992. Y1 - 1992. N2 - Cisplatin may evoke both an acute emetic response during the first 24 hours following treatment and a less well-recognized syndrome of delayed emesis. While delayed emesis is usually less severe in terms of frequency of vomiting episodes, the problem continues to result in significant morbidity. In comparison with acute emesis, the exact pathogenesis of the delayed emesis syndrome remains unclear. Although a combination of oral metoclopramide and dexamethasone is effective in many patients in preventing delayed emesis, almost 50% continue to experience at least one emetic episode when treated with this regimen. A phase III multicenter study has evaluated oral ondansetron ...
Vomiting associated with gastroparesis must be differentiated from regurgitation due to reflux or rumination syndrome. One unpublished study reported that ondansetron produced small but.. Gastroesophageal Reflux Therapies; Rehydration. vitamins during the first trimester and substitute them with folic acid or adult or childrens vitamins low in iron.. In addition to a previous diagnosis of CVS, the patients medical history included intrauterine stroke, global developmental delay, seizure disorder, and gastroesophageal reflux. lactic acid and.. Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy,. Mar 1, 2008. Doctors call it gastroesophageal reflux disease, or GERD. Millions of men call it heartburn, and many others have coughing, wheezing,. Zofran (ondansetron): I was diagnosed with GERD at 14 and whenever I feel. Zofran (ondansetron): I sufffer from ulcers & get acid indigestion all the ...
Ondansetron Injection USP by Sandoz: Ondansetron belongs to the class of medications called 5-HT3 receptor antagonists. This medication is used to prevent nausea and vomiting associated with certain types of cancer chemotherapy and radiation. It is also used to prevent and treat the nausea and vomiting that occurs after surgery.
Zofran - What is Zofran (ondansetron) taken for? I was prescribed Zofran (ondansetron) back in january 2012 but I dont remeber what its taken for. Zofran (ondansetron) It blocks the actions of chemicals in the body that can trigger nausea & vomiting. It can cause blurred vision & feeling like u would pass out.
There are many different forms and strengths of generic ondansetron. This eMedTV article explains that generic ondansetron is available in tablet form, as orally disintegrating tablets, as an oral liquid, or as an injection.
Ondansetron tablets are taken by mouth, refer to the directions below that match the type of tablets you were prescribed. Follow the directions on your prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.. Zofran® tablets: Take regular ondansetron tablets by mouth. Swallow the tablets with a drink of water.. Zofran ODT® tablets: These tablets are made to dissolve in the mouth without having to take them with water. Place the tablet in the mouth and allow it to dissolve, then swallow. While you may take these tablets with water, it is not necessary to do so.. If you are taking ondansetron to prevent nausea due to chemotherapy, the first dose of ondansetron is usually given 30 minutes before chemotherapy, followed by a dose at regular intervals for one or two days after chemotherapy.. ...
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Þ rst to demonstrate the antiemetic effects of ondansetron in AGE.[3] Reeves, 2002, also demonstrated the antiemetic properties Review of the literature shows clinicians commonly use and of ondansetron and a decreased hospital admission rate in those prescribe antiemetics for vomiting in children with AGE. A with a serum CO ,15 mEq/L.[14] Ramsook, 2002, was the Þ rst retrospective study of 20,000 children with AGE showed 9% of to compare oral ondansetron to placebo again demonstrating its patients had a prescription Þ lled for an antiemetic. In addition, antiemetic effect and also a decreased need for IVF and hospital 5% of patients under the age of 2 had a prescription Þ lled for admission. SigniÞ cantly higher rates of diarrhea were reported an antiemetic, the most common of which was promethazine in this study related to ondansetron as additional doses of this (Phenergan).[6] A survey of Italian pediatricians reported a 79% medication were given at discharge.[15] In 2006, Freedman ...
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A cost analysis of the emergency department administration of oral ondansetron to children with dehydration and vomiting secondary to gastroenteritis was performed
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Oral ondansetron given as a single dose of 0.1-0.25 mg/kg [13, 17] in the emergency department to children with mild to moderate dehydration decreases the number of children with persistent vomiting. It also decreases the number of children requiring IV rehydration and hospital admissions. Higher doses have also been used but any added advantage is not apparent [15]. Oral ondansetron may be useful as an adjunctive measure to ORT in the outpatient or primary care setting as well, although no study is available at the moment to confirm this. Thus, it should be an important area of future research.. Adverse effects reported with use of ondansetron were limited to increased mean episodes of diarrhea noticed in a few studies, although this was statistically non-significant. A possible explanation could be the variable duration of follow-up periods employed by different researchers, while it would be ideal for researchers to report the actual output volume of stool rather than the number of episodes ...
BACKGROUND: This study was designed to compare the efficacy of prophylactic ramosetron and ondansetron in preventing postoperative vomiting in children who received fentanyl by patient-controlled analgesia after orthopedic surgery. METHODS: Two hundr
Use of the antiemetic ondansetron during pregnancy was not associated with any adverse fetal outcomes, an observational study showed.
Zensana (ondansetron hydrochloride) oral spray is a new drug formulation in development to prevent nausea and vomiting after chemotherapy. Zensana information includes news, clinical trial results and side effects.
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Author: Allen Loyd V Jr, Year: 1997, Abstract: A formulation for preparing Ondansetron HCl-Doxorubicin Sulfate-Vincristine Sulfate Injection (2 concentrations). Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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