TY - JOUR. T1 - Different antibody response to a neutralizing epitope of human cytomegalovirus glycoprotein B among seropositive individuals. AU - Ayata, Minoru. AU - Sugano, Tohru. AU - Murayama, Tsugiya. AU - Sakamuro, Daitoku. AU - Takegami, Tsutomu. AU - Matsumoto, Yoh‐Ichi ‐I. AU - Furukawa, Toru. PY - 1994/8. Y1 - 1994/8. N2 - The amino‐terminal portion of human cytomeg‐alovirus glycoprotein B (HCMV‐gB) was expressed as a fusion protein to analyze the neutralizing epitope recognized by human monoclonal antibody C23 and the humoral immune response to this epitope. The linear neutralizing epitope was further localized to the pep‐tide within 17 amino acids (position 68‐84) which were conserved between two HCMV laboratory strains. Ten out of 17 HCMV‐seropositive human sera contained the antibody against this epitope. Although seven sera were negative for reacting with the fusion protein, the viruses isolated from the same patients retained the epitope. The immunogenicity of the ...

We assessed the value of the cytomegalovirus (CMV) antigenemia assay for diagnosing primary CMV infection in adults. The CMV antigenemia assay was performed for 40 patients admitted to our unit over a 2-year period with unexplained fever and suspected primary CMV infection. Nine of the 10 patients with primary CMV infection had positive CMV antigenemia assays, and the results were available within 5 hours. All 10 patients had a mononucleosis-like syndrome. All but one of the 30 other patients had negative CMV antigenemia assays. A false-positive result was obtained for a patient with systemic lupus erythematosus. Overall, the CMV antigenemia assay was 90% sensitive and 96% specific for the diagnosis of primary CMV infection. Therefore, the CMV antigenemia assay appears to be a simple, rapid, inexpensive test for the diagnosis of primary CMV infection in hospitalized adults.. ...

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To study the cellular signals underlying the regulatory mechanisms involved in maintenance of sarcomeric integrity, we have used quail skeletal muscle cells that reach a high degree of structural maturation in vitro, and also express a temperature-sensitive mutant of the v-Src tyrosine kinase that allows the control of differentiation in a reversible manner. By immunofluorescence and electron microscopy we show that v-Src activity in myotubes leads to an extensive cellular remodeling which affects components of the sarcomeres, the cytoskeleton network and the triad junctions. We have previously shown that activation of v-Src causes a selective dismantling of the I-Z-I segments coupled to the formation of aggregates of sarcomeric actin, alpha-actinin and vinculin, called actin bodies. We now show that intermediate filaments do not participate in the formation of actin bodies, while talin, a component of costameres, does. The I-Z-I segments are completely dismantled within 24 hours of v-Src ...

Epstein-Barr virus latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV) protein that regulates its own expression and the expression of human genes. LMP1 has a molecular weight of approximately 63 kDa, and its expression induces many of the changes associated with EBV infections and activation of primary B cells. LMP1 is the best-documented oncoprotein of the EBV latent gene products, as it is expressed in most EBV-related human cancers. The structure of LMP1 consists of a short cytoplasmic N-terminus tail, six trans-membrane domains, and a long cytoplasmic C-terminus, which contains three activating domains: CTARt, CTAR2, and CTAR3. Each CTAR domain contains an amino acid sequence that serves as a recognition site for cellular adaptors to bind and trigger a series of signal transduction pathways that can lead to a change in gene expression. LMP-1 is a functional homologue of tumor necrosis factor and mediates signaling through the nuclear factor-κB pathway, mimicking CD40 receptor ...

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We present a case of Primary cytomegalovirus infection presented in mid-trimester with itching and obstetric cholestasis like picture. To the best of our knowledge the similarities between primary CMV and obstetric cholestasis, when presenting during pregnancy, have not been highlighted before in the literature. Case Report: A 36 year old lady presented to antenatal clinic at 23+4 weeks gestational age with intense itching. Bile acids and ALT were raised so she was treated as obstetric cholestasis whilst other results were awaited. Cytomegalovirus (CMV) antibodies, immunoglobulin G (IgG) and IgM were positive despite being negative at booking, suggesting an acquisition of CMV at approximately 18 weeks gestation. This article highlights the details of her case including the management and consequences of cytomegalovirus in pregnancy. Conclusion: This case report highlights the importance of the awareness of the clinicians with the condition as a differential diagnosis to obstetric cholestasis. CMV should

The Receptor Tyrosine Kinase (RTK) Met influences behaviour of several cancers by controlling growth, survival and metastasis. Recently, compartmentalisation of signals generated by RTKs, due to their endocytosis / trafficking, has emerged as a major determinant of various cell functions. The aim of my project was to study oncogenic Met signalling in relation to endosomal trafficking and to determine the consequences of such spatial changes on tumour cell growth and migration in vitro and in vivo. The model studied was NIH3T3 cells stably transfected with Wild type (Wt) Met or with three distinct mutants reported in human cancers. I found that two activating mutations in the kinase domain are highly tumorigenic in vivo. Using functional assays and tumour growth experiments, I demonstrated that one mutant is highly sensitive to Met specific tyrosine kinase inhibitors (TKI) while another is resistant. Such results suggested that therapeutical approaches to these mutants should be different. ...

TY - JOUR. T1 - UL54 foscarnet mutation in an hematopoietic stem cell transplant recipient with cytomegalovirus disease. AU - Gregg, K.. AU - Hakki, Morgan. AU - Kaul, D. R.. PY - 2014. Y1 - 2014. N2 - We present a case of foscarnet (FOS) resistance arising from a UL54 mutation after a short duration of FOS exposure, which has not been previously described in a stem cell transplant recipient, to our knowledge. We discuss the use of FOS to treat other viral infections and the implications this may have for the development of resistance mutations and treatment of cytomegalovirus disease.. AB - We present a case of foscarnet (FOS) resistance arising from a UL54 mutation after a short duration of FOS exposure, which has not been previously described in a stem cell transplant recipient, to our knowledge. We discuss the use of FOS to treat other viral infections and the implications this may have for the development of resistance mutations and treatment of cytomegalovirus disease.. KW - ...

Cytomegalovirus (CMV) infection causes significant morbidity and mortality in the setting of immunodeficiency, including the immune reconstitution phase following allogeneic stem cell transplantation (SCT). We assessed CMV-specific CD4(+) and CD8(+) T-cell responses in 87 HLA-A*0201-positive (A2+) and/or B*0702-positive (B7+) allogeneic stem cell transplant recipients using HLA-peptide tetramer staining and cytokine flow cytometry (CFC) to examine the association of CMV-specific immune reconstitution and CMV antigenemia following SCT. Strong CMV-specific T-cell responses recovered in most subjects (77 of 87, 88%) after SCT. Frequencies of CMV-specific CD8(+) T cells were significantly higher in those subjects who experienced early antigenemia relative to those who did not (2.2% vs 0.33%, P =.0002), as were frequencies of CMV-specific CD4(+) T cells (1.71% vs 0.75%, P =.002). Frequencies of CMV-specific CD8(+) T cells were also higher in subjects experiencing late antigenemia (2.4% vs 0.57%). When we

The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras ...

TY - JOUR. T1 - The ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes. AU - Soni, Smita P.. AU - Stahelin, Robert V.. PY - 2014/11/28. Y1 - 2014/11/28. N2 - Ebola virus is from the Filoviridae family of viruses and is one of the most virulent pathogens known with ∼60% clinical fatality. The Ebola virus negative sense RNA genome encodes seven proteins including viral matrix protein 40 (VP40), which is the most abundant protein found in the virions. Within infected cells VP40 localizes at the inner leaflet of the plasma membrane (PM), binds lipids, and regulates formation of new virus particles. Expression of VP40 in mammalian cells is sufficient to form virus-like particles that are nearly indistinguishable from the authentic virions. However, how VP40 interacts with the PM and forms virus-like particles is for the most part unknown. To investigate VP40 lipid specificity in a model of viral egress we employed giant unilamellar vesicles ...

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Fibrosis is tissue that has fiber-like characteristics which develop in place of the normal smooth walls of the heart. Fibrotic tissue is scarred, immobile, basically dead tissue with reduced or no blood flow and no transport function. It results in a loss of atrial muscle mass. Over time it makes the heart stiff, less flexible and weak, overworks the heart, reduces pumping efficiency and leads to other heart problems. Fibrosis, up to now, was considered permanent and irreversible.. Dr. Jalife described Galectin-3 (Gal-3), a protein that produces ("mediates") tissue fibrosis. (It's also involved in inflammation, immune response, cancer, heart disease and stroke.) For you technical types, "Gal-3 pentamers bind to poly N-acetyl lactosamine (LNac) residues on TGF receptors of myofibroblasts causing cell surface retention and promoting signaling through Smad and AKT pathways and leading to fibrosis." (For us non-technical types, all we need to know is that Gal-3 promotes fibrosis.). When sheep are ...

TY - JOUR. T1 - Cytomegalovirus Retinitis After Fluocinolone Acetonide (Retisert™) Implant. AU - Ufret-Vincenty, Rafael L.. AU - Singh, Rishi P.. AU - Lowder, Careen Y.. AU - Kaiser, Peter K.. PY - 2007/2. Y1 - 2007/2. N2 - Purpose: To report a case of cytomegalovirus (CMV) retinitis after placement of a fluocinolone acetonide (Retisert™) implant. Design: Interventional case report. Methods: Retrospective chart review. Results: A 65-year-old man with a history of Adamantiades-Behcet disease and bilateral recurrent uveitis that was unresponsive to systemic corticosteroid-sparing immunosuppressive therapy developed clinical evidence of CMV retinitis after receiving his second intravitreal Retisert™ implant in the left eye, while on no systemic immunosuppression. He did not develop CMV retinitis in the right eye despite multiple intraocular and periocular steroid injections. The patient responded well to intravitreal foscarnet followed by placement of an intravitreal ganciclovir implant. ...

Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Signal transducers and activators of transcription (STATs) were originally identified as key components of signaling pathways involved in mediating responses to IFNs. Previous studies showed that the Src oncoprotein constitutively activates one STAT family member, Stat3. In this study, we investigated STAT activation in a panel of rodent fibroblast cell lines stably transformed by diverse viral oncoproteins. Using a temperature-sensitive mutant of v-Src, we determined that Stat3 is activated within 15 min of shift from nonpermissive to permissive temperature for cell transformation. This finding indicates that v-Src tyrosine kinase activity is required for Stat3 activation and suggests that Stat3 is proximal to signaling initiated by Src. In addition, Stat3 activation is induced by another nonreceptor tyrosine kinase, v-Fps; by polyoma virus middle T antigen, which activates Src family kinases; ...

To define relationships between 1) HIV load and risk of CMV disease, 2) CMV load and the risk of developing CMV disease, and 3) CMV load and HIV load. To establish threshold CMV and HIV load values in peripheral blood fractions that are associated with development of CMV end-organ disease. To define the natural history of CMV diseases in the context of highly active antiretroviral therapy (HAART).. Establishment of threshold CMV and HIV load values associated with CMV disease would facilitate identification of HIV-infected individuals truly at risk for CMV disease in whom targeted prophylactic interventions to prevent CMV disease would be indicated. These studies would also further the understanding of the natural history of CMV disease within the context of AIDS. Natural history studies conducted prior to the advent of highly active antiretroviral therapy (HAART; i.e., 3-drug regimens that include HIV reverse transcriptase and protease inhibitors) have demonstrated that the risk for developing ...

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Epstein-Barr virus (EBV), a human herpes virus with oncogenic potential, persists in B lymphoid tissues and is controlled by virus-specific cytotoxic T lymphocyte (CTL) surveillance. On reactivation in vitro, these CTLs recognize EBV-transformed lymphoblastoid cell lines (LCLs) in an HLA class I antigen-restricted fashion, but the viral antigens providing target epitopes for such recognition remain largely undefined. Here we have tested EBV-induced polyclonal CTL preparations from 16 virus-immune donors on appropriate fibroblast targets in which the eight EBV latent proteins normally found in LCLs (Epstein-Barr nuclear antigen [EBNA] 1, 2, 3A, 3B, 3C, leader protein [LP], and latent membrane protein [LMP] 1 and 2) have been expressed individually from recombinant vaccinia virus vectors. Most donors gave multicomponent responses with two or more separate reactivities against different viral antigens. Although precise target antigen choice was clearly influenced by the donor's HLA class I type, a ...

Sequence Variations of Latent Membrane Protein 2A in Epstein-Barr Virus-Associated Gastric Carcinomas from Guangzhou, Southern China. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

TY - JOUR. T1 - Splenic infarction caused by a rare coinfection of epstein-barr virus, cytomegalovirus, and mycoplasma pneumoniae. AU - Li, Yulong. AU - Pattan, Vishwanath. AU - Syed, Beena. AU - Islam, Mohammed. AU - Yousif, Abdalla. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Epstein-Barr virus (EBV), cytomegalovirus (CMV), and Mycoplasma pneumoniae are common pathogens of respiratory infection among children and young adults. Although single infection of 1 of these pathogens is common enough, their coinfection has been rarely reported. A 19-year-old woman presented with severe upper abdominal pain for 5 hours as well as flu-like symptoms and jaundice for 2 to 3 weeks. Initial tests found pancytopenia, abnormal liver functions, and presence of atypical lymphocytes in blood smear; the computed tomography of the abdomen revealed para-Aortic lymphadenopathy, splenomegaly, and a wedge-shaped focal hypodensity lesion at the periphery of the spleen that was later diagnosed as splenic infarction. Her ...

TY - JOUR. T1 - Erratum. T2 - Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors (Proc. Natl. Acad. Sci. USA (May 1, 1992) 89:9 (4042-4046)). AU - Jones, D.. AU - Lee, L.. AU - Liu, J. L.. AU - Kung, Hsing-Jien. AU - Tillotson, J. K.. PY - 1993. Y1 - 1993. UR - http://www.scopus.com/inward/record.url?scp=0027474633&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027474633&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0027474633. VL - 90. SP - 2556. JO - Proceedings of the National Academy of Sciences of the United States of America. JF - Proceedings of the National Academy of Sciences of the United States of America. SN - 0027-8424. IS - 6. ER - ...

Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene. MafK is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFK is "v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K". MafK was first cloned and identified in chicken in 1993 as a member of the small Maf (sMaf) genes. MafK was also identified as p18 NF-E2, a component of NF-E2 complex binding to a specific motif (NF-E2) in the regulatory regions of β-globin and other erythroid-related genes. MAFK has been identified in many vertebrates, including humans. There are three functionally redundant sMaf proteins in vertebrates, MafF, MafG, and MafK. MafK has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. Similar to other sMafs, MafK lacks any canonical transcriptional activation domains. ...

The MET oncogene represents an exciting therapeutic target in advanced NSCLC, with at least six MET TKIs currently in clinical development across the three different settings where genomic alterations suggest dependence upon oncogenic MET (Supplementary Table S2): de novo MET amplification, MET exon 14 skipping mutations, and MET amplification in resistance to EGFR TKIs. At least eight different combinations of MET and EGFR TKIs are being investigated in the context of EGFR TKI resistance. Our finding of a MET kinase domain mutation that leads to resistance to type I but not type II MET TKIs highlights the potential value of both classes of drugs in the management of NSCLC, as patients resistant to type I MET inhibitors may subsequently still respond to a type II MET inhibitor. Our findings are consistent with prior preclinical work using a mutagenesis-based resistance screen which found that MET mutations at D1228 cause resistance to NVP-BVU972 but not to AMG 458 (13).. This is not dissimilar ...

We have investigated whether the recently discovered transcription element, zinc little finger BED domain-containing proteins 6 (ZBED6), is expressed in insulin-producing cells and, if thus, to what degree it affects beta cell function. function of insulin-producing beta cells. For example, genetics code for transcription elements important to the pancreatic beta cellsuch as Neurog3, Nkx6.1, NeuroD2, and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA)were found to be putative joining focuses on for ZBED6 in myoblast cells (1). ZBED6-mediated control of may become relevant to beta cells because it offers been noticed that extravagant IGF2 creation in embryonic pancreas forwent the following beta cell mass anomaly that evolves in diabetic GotoCKakizaki rodents (3). Furthermore, the human being gene is usually clustered carefully collectively with (4), directing to the probability that not really just might become managed by a common ZBED6-reliant regulatory system. Therefore, it is ...

This graph shows the total number of publications written about "Oncogene Protein p55(v-myc)" by people in this website by year, and whether "Oncogene Protein p55(v-myc)" was a major or minor topic of these publications ...

TY - JOUR. T1 - Vaccination with different M2e epitope densities confers partial protection against H5N1 influenza A virus challenge in chickens. AU - Zhang, Xintao. AU - Liu, Ming. AU - Liu, Chunguo. AU - Du, Jinling. AU - Shi, Weilin. AU - Sun, Encheng. AU - Li, Hongtao. AU - Li, Jianhui. AU - Zhang, Yun. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2011/8. Y1 - 2011/8. N2 - Objective: Currently, research is focused on universal influenza vaccines based on various ectodomains of the influenza matrix protein 2 (M2e). Such vaccines are tested mostly using mouse-adapted influenza viruses and in mouse or ferret models. The aim of this study was to investigate in a chicken model the protective efficacy of vaccines based on avian-type M2e at different epitope densities. Methods: On the basis of the optimized avian-type M2e gene, recombinant plasmids that contained tandem copies of different M2e were constructed and expressed in Escherichia coli. The expression and ...

TY - JOUR. T1 - Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene. AU - Buckhaults, Phillip. AU - Chen, Lin. AU - Fregien, Nevis. AU - Pierce, Michael. PY - 1997/8/1. Y1 - 1997/8/1. N2 - Transformation of baby hamster kidney fibroblasts by the Rous sarcoma virus causes a significant increase in the GlcNAcβ(1,6)Man-branched oligosaccharides by elevating the activity and mRNA transcript levels encoding N-acetylglucosaminyltransferase V (GlcNAc-T V). Elevated activity and mRNA levels could be inhibited by blocking cell proliferation with herbimycin A, demonstrating that Src kinase activity can regulate GlcNAc-T V expression. 5' RACE analysis was used to identify a 3-kilobase 5'- untranslated region from GlcNAc-T V mRNA and locate a transcriptional start site in a 25-kilobase pair GlcNAc-T V human genomic clone. A 6-kilobase pair fragment of the 5' region of the gene contained AP-1 and PEA3/Ets binding elements and, when co-transfected with a src expression plasmid ...

A-myb, a conserved member of the Myb proto-oncogene family, encodes a sequence-specific DNA binding protein (A-Myb) that binds to and transactivates promoters containing myb-binding sites. Previous work has suggested that the C-terminus of A-Myb func

Two previously healthy adults with acute granulomatous hepatitis attributable to cytomegalovirus (CMV) monucleosis had prolonged fever, heterophil-negative lymphocytosis with numerous atypical forms, minor alterations in hepatic function, and evidence on biopsy, of a nonspecific acute hepatitis with granulomata. Infection with CMV was corroborated by a rising titer of complement-fixing antibody in case 1 and by a high titer of antibody that later fell in case 2. It is important to exclude CMV ivfection as an etiologic factor in cases of acute granulomatous hepatitis and fever of unknown origin.

Sjögren's syndrome (SS) is an autoimmune disease in which exocrine tissues are affected by cellular and humoral immunity. As a result, the salivary and lacrimal glands of patients with SS are damaged, leading to xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Because experimental approaches to investigate SS pathogenesis in human patients are limited, development of a mouse model is indispensable for understanding the disease. In this study, we show that special AT-rich sequence binding protein-1 conditional knockout (SATB1cKO) mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop SS by 4 wk of age, soon after weaning ...

The maintenance of CMV-specific T cell memory in lung transplant recipients (LTRs) is critical for host defense and allograft durability, in donor+/recipient particularly? (Chemical+Ur?) people who demonstrate elevated fatality. both preferential distribution and useful quality of CMV-specific Compact disc4+ storage in the lung allograft during chronic an infection, and display an essential association with CMV mucosal defenses and virus-like control. CMV-specific effector replies during severe principal an infection predominated by Compact disc8+ Testosterone levels cells described toward the main antigen pp65 in the lung allograft (10). While these scholarly research demonstrated the pay for and tenacity of CMV-specific Testosterone levels cells able of making IFN-, the quality and distribution of storage subsets, i.y. the level of multifunctionality of antigen-specific cells during chronic CMV an infection in this prone individual people, are unsure. Lately, many research have got showed that ...

TY - JOUR. T1 - Treatment of Epstein-Barr virus-associated malignancies with specific T cells. AU - Gottschalk, Stephen. AU - Heslop, Helen. AU - Rooney, Cliona M.. PY - 2002. Y1 - 2002. N2 - Latent Epstein-Barr virus (EBV) infection is associated with a heterogeneous group of malignancies, including Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma, and lymphoproliferative disease (LPD). The development of adoptive immunotherapies for these malignancies is being fueled by the successful generation of allogeneic donor derived EBV-specific cytotoxic T cells (CTL) for the prevention and treatment of EBV-LPD after hematopoietic stem cell transplantation. This approach is being extended to EBV-LPD after solid organ transplantation by use of autologous and haploidentical EBV-specific CTL. For other EBV-associated malignancies, there is only limited clinical experience with EBV-specific CTL. With few exceptions, only patients with recurrent Hodgkin's disease have been treated with ...

Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized ...

TY - JOUR. T1 - Vitamin D level after allogeneic hematopoietic stem cell transplant. AU - Sproat, Lisa. AU - Bolwell, Brian. AU - Rybicki, Lisa. AU - Dean, Robert. AU - Sobecks, Ronald. AU - Pohlman, Brad. AU - Andresen, Steven. AU - Sweetenham, John. AU - Copelan, Edward. AU - Kalaycio, Matt. PY - 2011/7. Y1 - 2011/7. N2 - Vitamin D (VD) deficiency can cause osteomalacia, bone pain, muscle weakness, fatigue, and increased risk of fracture, and may precipitate or exacerbate osteopenia and osteoporosis. Patients receiving treatment for acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) may have limited exposure to sunlight and often experience gastrointestinal side effects that may decrease their ability to maintain an adequate VD level. We hypothesized that patients with AML and ALL would have a low VD level after allogeneic hematopoietic cell transplant (HCT), and that these patients would have a high incidence of osteoporosis/osteopenia. We therefore studied the incidence of ...

v-Src is a gene found in Rous sarcoma virus that encodes a tyrosine kinase that causes a type of cancer in chickens. The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells. It was the first retroviral oncogene to be discovered. The src gene was taken up by RSV and incorporated into its genome conferring it with the advantage of being able to stimulate uncontrolled mitosis of host cells, providing abundant cells for fresh infection. The src gene is not essential for RSV proliferation but it greatly increases virulence when present. Francis Peyton Rous first proposed that viruses can cause cancer. He proved it in 1911 and was later awarded the Nobel prize in 1966. Chickens grow a tumor called a fibrosarcoma. Rous collected and ground up these sarcomas, and then centrifuged them to remove the solid material. Next, the remaining liquid mixture was injected into chicks. The chicks developed sarcomas. The causative agent in the liquid was a virus, this is now called the ...

Rous sarcoma virus definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!

Oncogene Proteins v-mos: Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).

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Oncogene Protein v-crk: A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.

Whitmore, A C.; Babcock, G F.; and Haughton, G, "Genetic control of susceptibility of mice to rous sarcoma virus tumorigenesis. II. Segregation analysis of strain a.sw- -associated Resistance to primary tumor induction." (1978). Subject Strain Bibliography 1978. 4038 ...

The intracellular protein tyrosine kinase FAK (focal adhesion kinase) was originally identified gy its high level of tyrosine phosphorylation in v-src-transformed cells. FAK is also highly phosphorylated during early development. In cultured cells it is localized to focal adhesion contacts and becom …

Invasive carcinoma cells use specialized actin polymerization-driven protrusions called invadopodia to degrade and possibly invade through the extracellular matrix (ECM) during metastasis. Phosphorylation of the invadopodium protein cortactin is a master switch that activates invadopodium maturation and function. Cortactin was originally identified as a hyperphosphorylated protein in v-Src-transformed cells, but the kinase or kinases that are directly responsible for cortactin phosphorylation in invadopodia remain unknown. In this study, we provide evidence that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growth factor (EGF)-induced cortactin phosphorylation, triggering actin polymerization in invadopodia, ECM degradation, and matrix proteolysis-dependent tumor cell invasion. Both Src and Arg localize to invadopodia and are required for EGF-induced actin polymerization. Notably, Arg overexpression in Src knockdown cells can partially rescue actin polymerization in ...

The results of the RT-PCR assay and EMSA, shown in this study, have established that Bach2 functions in B cells as a major MARE‐binding factor. In terms of cell differentiation, B cell is the second hematopoietic cell lineage in which partners of MARE‐effectors have been identified, with a precedent being NF‐E2 p45 in erythroid cells (Andrews et al., 1993a, b; Igarashi et al., 1994). This is somewhat surprising in view of our previous observation that, among various hematopoietic cell lines tested, Bach2 expression was detected in the monocytic leukemic cell line M1 but not in BaF3 cells, which are supposed to have a pro‐B status (Oyake et al., 1996). However, in this study we examined Bach2 expression in primary B cells and in a large set of established B‐cell lines, and the results clearly indicate that Bach2 is in fact a B‐cell‐specific factor. The specific deployment of Bach2 in B cells suggests that Bach2 and its interacting bZip proteins are important regulators of B‐cell ...

What is the interpretation of a confidence interval following estimation of a Box-Cox transformation parameter ?? Several authors have argued that confidence intervals for linear model parameters ? can be constructed as if ? were known in advance, rather than estimated, provided the estimand is interpreted conditionally given ??. If the estimand is defined as ? (??), a function of the estimated transformation, can the nominal confidence level be regarded as a conditional coverage probability given ??, where the interval is random and the estimand is fixed? Or should it be regarded as an unconditional probability, where both the interval and the estimand are random? This article investigates these questions via large-n approximations, small-? approximations, and simulations. It is shown that, when model assumptions are satisfied and n is large, the nominal confidence level closely approximates the conditional coverage probability. When n is small, this conditional approximation is still good for

A genomic sequence and cloned complementary DNA has been identified for a novel receptor-like gene of the PDGF receptor/CSF1 receptor subfamily (platelet-derived growth factor receptor/colony-stimulating factor type 1 receptor). The gene recognized a 6.4-kilobase transcript that was coexpressed in normal human tissues with the 5.3-kilobase PDGF receptor messenger RNA. Introduction of complementary DNA of the novel gene into COS-1 cells led to expression of proteins that were specifically detected with antiserum directed against a predicted peptide. When the new gene was transfected into COS-1 cells, a characteristic pattern of binding of the PDGF isoforms was observed, which was different from the pattern observed with the known PDGF receptor. Tyrosine phosphorylation of the receptor in response to the PDGF isoforms was also different from the known receptor. The new PDGF receptor gene was localized to chromosome 4q11-4q12. The existence of genes encoding two PDGF receptors that interact in a ...

A faulty MAF sensor in your Mercedes can seriously affect the performance of the car and lead to costly repairs. Here are the signs of a Faulty MAF sensor.

The human geography of Vietnam's upland area has been transformed significantly during the last 40 years due to the increasing control from the central government. We argue that State territorialisation, understood as a strategy of State-making and assertion of the State's authority, has the tendency to marginalise, socially and politically, local ethnic minority peoples by excluding them from indigenous social and economic geography and the use of natural resources. At the receiving end of these official policies, the local ethnic minority people do not passively accept their marginalisation but are able to initiate the use of traditional cross-border cultural resources to improve their condition. By analysing the tolerance from local official towards illicit cross-border activities daily carried out by local people, the case study provides some insights on the dynamics of power struggle between the State and local people. We concluded that local ethnic minority peoples actively re-negotiate with more