Oncogene Proteins v-mos: Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).

Table of contents 1. Report Introduction. 2. Myc Proto Oncogene Protein 3. Myc Proto Oncogene Protein Current Treatment Patterns. 4. Myc Proto Oncogene Protein - DelveInsight's Analytical Perspective. 5. Therapeutic Assessment. 6. Myc Proto Oncogene Protein Late Stage Products (Phase-III). 7. Myc Proto Oncogene Protein Mid Stage Products (Phase-II). 8. Early Stage Products (Phase-I). 9. Pre-clinical Products and Discovery Stage Products. 10. Inactive Products. 11. Dormant Products. 12. Myc Proto Oncogene Protein Discontinued Products. 13. Myc Proto Oncogene Protein Product Profiles. 14. Myc Proto Oncogene Protein Key Companies. 15. Myc Proto Oncogene Protein Key Products. 16. Dormant and Discontinued Products. 17. Myc Proto Oncogene Protein Unmet Needs. 18. Myc Proto Oncogene Protein Future Perspectives. 19. Myc Proto Oncogene Protein Analyst Review 20. Appendix. 21. Report Methodology. Request Sample Pages @ Myc Proto Oncogene Protein Clinical Trials. Media Contact ...

TY - JOUR. T1 - Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta. AU - Liu, Ya Guang. AU - Tekmal, Rajeshwar R.. AU - Binkley, Peter A.. AU - Nair, Hareesh B.. AU - Schenken, Robert S.. AU - Kirma, Nameer B.. N1 - Funding Information: This work was supported by the National Institutes of Health (CA P30CA54174 and R01 HD049637-01A2 to R.R.T.) and the University Research Council, University of Texas Health Science Center at San Antonio (10003554 to N.B.K.).. PY - 2009. Y1 - 2009. N2 - Transforming growth factor beta 1 (TGF-β1) levels are increased in the peritoneal fluid of endometriosis patients, and endometrial cells express TGF-β signaling components; however, little is known regarding the role of TGF-β in endometriosis. Our objective was to examine the effects of TGF-β1 on (i) the expression of macrophage colony-stimulating factor receptor encoded by the c-fms gene, (ii) transmesothelial invasiveness of endometrial cells, (iii) ...

TY - JOUR. T1 - The P55 protein affected by v-mos expression is vimentin. AU - Singh, B.. AU - Goldman, R.. AU - Hutton, L.. AU - Herzog, N. K.. AU - Arlinghaus, R. B.. PY - 1987. Y1 - 1987. N2 - Rabbit antiserum prepared against a cyclic 19-amino-acid peptide predicted from the sequence of the viral mos gene (v-mos) of Moloney murine sarcoma virus not only recognized v-mos gene products but also specifically detected a 55,000-M(r) polypeptide expressed in a variety of cells that grow on solid surfaces. This normal cellular protein, previously shown to be reduced in amount in cells expressing the v-mos gene, was found to be the intermediate filament structural protein, vimentin. This conclusion was reached by comparing relative mobilities in denaturing gels, isoelectric points, immunoreactivities, location in the cell, and peptide maps.. AB - Rabbit antiserum prepared against a cyclic 19-amino-acid peptide predicted from the sequence of the viral mos gene (v-mos) of Moloney murine sarcoma virus ...

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The Receptor Tyrosine Kinase (RTK) Met influences behaviour of several cancers by controlling growth, survival and metastasis. Recently, compartmentalisation of signals generated by RTKs, due to their endocytosis / trafficking, has emerged as a major determinant of various cell functions. The aim of my project was to study oncogenic Met signalling in relation to endosomal trafficking and to determine the consequences of such spatial changes on tumour cell growth and migration in vitro and in vivo. The model studied was NIH3T3 cells stably transfected with Wild type (Wt) Met or with three distinct mutants reported in human cancers. I found that two activating mutations in the kinase domain are highly tumorigenic in vivo. Using functional assays and tumour growth experiments, I demonstrated that one mutant is highly sensitive to Met specific tyrosine kinase inhibitors (TKI) while another is resistant. Such results suggested that therapeutical approaches to these mutants should be different. ...

TY - JOUR. T1 - Expression of murine leukemia virus envelope glycoprotein gp69/71 on mouse thymocytes. Evidence for two structural variants distinguished by presence vs absence of G(ix) antigen. AU - Tung, J. S.. AU - Fleissner, E.. AU - Vitetta, E. S.. AU - Boyse, E. A.. PY - 1975. Y1 - 1975. N2 - Thymocytes of several mouse strains were tested for expression of the gp69/71 envelope component of murine leukemia virus by surface iodination (125I), followed by immunoprecipitation and sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis. These strains included two congenic lines differing from their partner stocks with respect to expression of G(IX) antigen demonstrable in the cytotoxicity assay. It is concluded that two structural variants of gp69/71 can be expressed on mouse thymocytes, that these are distinguishable by a small difference in mobility in SDS gels, that one carries G(IX) antigen and the other not, that they are coded, or their expression is regulated, by different ...

The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras ...

In this study, we have investigated the effect of specific mutations in human immunodeficiency virus type 1 (HIV-1) envelope (Env) on antibody production in an effort to improve humoral immune responses to this glycoprotein by DNA vaccination. Mice were injected with plasmid expression vectors encoding HIV Env with modifications in regions that might affect this response. Elimination of conserved glycosylation sites did not substantially enhance humoral or cytotoxic-T-lymphocyte (CTL) immunity. In contrast, a modified gp140 with different COOH-terminal mutations intended to mimic a fusion intermediate and stabilize trimer formation enhanced humoral immunity without reducing the efficacy of the CTL response. This mutant, with deletions in the cleavage site, fusogenic domain, and spacing of heptad repeats 1 and 2, retained native antigenic conformational determinants as defined by binding to known monoclonal antibodies or CD4, oligomer formation, and virus neutralization in vitro. Importantly, ...

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Fibrosis is tissue that has fiber-like characteristics which develop in place of the normal smooth walls of the heart. Fibrotic tissue is scarred, immobile, basically dead tissue with reduced or no blood flow and no transport function. It results in a loss of atrial muscle mass. Over time it makes the heart stiff, less flexible and weak, overworks the heart, reduces pumping efficiency and leads to other heart problems. Fibrosis, up to now, was considered permanent and irreversible.. Dr. Jalife described Galectin-3 (Gal-3), a protein that produces ("mediates") tissue fibrosis. (It's also involved in inflammation, immune response, cancer, heart disease and stroke.) For you technical types, "Gal-3 pentamers bind to poly N-acetyl lactosamine (LNac) residues on TGF receptors of myofibroblasts causing cell surface retention and promoting signaling through Smad and AKT pathways and leading to fibrosis." (For us non-technical types, all we need to know is that Gal-3 promotes fibrosis.). When sheep are ...

The Bridging Sheet domain of HIV-1 gp120 is highly conserved among the HIV-1 strains and allows HIV-1 binding to host cells via the HIV-1 coreceptors. Further, the bridging sheet domain is a major target to neutralize HIV-1 infection. We rationally designed four linear peptide epitopes that mimic the three-dimensional structure of bridging sheet by using molecular modeling. Chemically synthesized peptides BS3 and BS4 showed a fair degree of antigenicity when tested in ELISA with IgG purified from HIV+ broadly neutralizing sera while the production of synthetic peptides BS1 and BS2 failed due to their high degree of hydrophobicity. To overcome this limitation, we linked all four BS peptides to the COOH-terminus of GST protein to test both their antigenicity and immunogenicity. Only the BS1 peptide showed good antigenicity; however, no envelope specific antibodies were elicited upon mice immunization. Therefore we performed further analyses by linking BS1 peptide to the NH2-terminus of the E2 scaffold

The occurrence of clinical manifestations associated with primary human immunodeficiency virus type 1 (HIV-1) infection was evaluated in a prospective cohort study of female sex workers in Mombasa, Kenya. Among 103 women who seroconverted to HIV-1, fever, vomiting, diarrhea, headache, arthralgia, myalgia, skin rash, swollen lymph nodes, extrainguinal lymphadenopathy, inguinal lymphadenopathy, and vaginal candidiasis were noted significantly more frequently at visits in which seroconversion first became evident. Eighty-one percent of seroconverting women had ≥1 of these 11 symptoms or signs. Among 44% of the women, the acute illness was severe enough to prevent them from working. Having ≥2 of 6 selected symptoms and signs yielded a sensitivity of 51%, specificity of 83%, positive likelihood ratio of 3.2, and negative likelihood ratio of 0.5 for acute HIV-1 infection. The recognition of primary HIV-1-infection illness in high-risk populations and subsequent risk-reduction counseling could ...

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TY - JOUR. T1 - Role of CSF-1 in progression of epithelial ovarian cancer. AU - Chambers, Setsuko K. PY - 2009. Y1 - 2009. N2 - Despite the dismal outcome seen in the majority of epithelial ovarian cancer patients, there is ongoing progress in understanding the disease at a molecular level. Elucidation of pathways underlying disease progression and metastasis of ovarian cancer is key to development of targeted therapeutics. It is only in this way that therapeutic potential can be translated to reality. Here, we describe the evidence to date for the role of CSF-1/c-fms signaling in ovarian cancer invasiveness and metastasis, including the recent understanding of how CSF-1/c-fms expression is regulated with identification of significant post-transcriptional regulators.. AB - Despite the dismal outcome seen in the majority of epithelial ovarian cancer patients, there is ongoing progress in understanding the disease at a molecular level. Elucidation of pathways underlying disease progression and ...

Transforming Proteins coded by mos Oncogenes. The v-mos Proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV ...

Human immunodeficiency virus type 1 (HIV-1) enters cells through the chemokine receptors CCR5 (R5 virus) and/or CXCR4 (X4 virus). Loss of N-linked glycans and increased net charge of the third variable loop (V3) of the gp120 envelope glycoprotein have been observed to be important steps towards CXCR4 use. All reported sequences using CCR5 or CXCR4 exclusively, or using both, were gathered from the Los Alamos HIV Database and analysed with regard to the V3 N-linked glycosylation motifs (sequons) and charge. The V3 loop glycan had a sensitivity of 0·98 and a 0·92 positive predictive value in the context of CCR5 use. The difference from X4 was remarkable (P<10−12). Especially, the sequon motif NNT within the V3 loop was conserved in 99·2 % of the major clades. The results suggest a close association between the V3 loop glycan and CCR5 use and may provide new insight into HIV-1 tropism and help to improve phenotype-prediction models.

TY - JOUR. T1 - Erratum. T2 - Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors (Proc. Natl. Acad. Sci. USA (May 1, 1992) 89:9 (4042-4046)). AU - Jones, D.. AU - Lee, L.. AU - Liu, J. L.. AU - Kung, Hsing-Jien. AU - Tillotson, J. K.. PY - 1993. Y1 - 1993. UR - http://www.scopus.com/inward/record.url?scp=0027474633&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027474633&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0027474633. VL - 90. SP - 2556. JO - Proceedings of the National Academy of Sciences of the United States of America. JF - Proceedings of the National Academy of Sciences of the United States of America. SN - 0027-8424. IS - 6. ER - ...

Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene. MafK is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFK is "v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K". MafK was first cloned and identified in chicken in 1993 as a member of the small Maf (sMaf) genes. MafK was also identified as p18 NF-E2, a component of NF-E2 complex binding to a specific motif (NF-E2) in the regulatory regions of β-globin and other erythroid-related genes. MAFK has been identified in many vertebrates, including humans. There are three functionally redundant sMaf proteins in vertebrates, MafF, MafG, and MafK. MafK has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. Similar to other sMafs, MafK lacks any canonical transcriptional activation domains. ...

Cerebrospinal Fluid Neopterin in Human Immunodeficiency Virus Type 1 Infection Bruce J. Brew, MB, FRACP,' Ravi B. Bhalla, PhD,? Morris Paul, PhD,* H. Gallardo, MS,* Justin C. McArthur, MBBS,S Morton K. Schwartz, PhD,t and &chard W. Price, MD' We evaluated cerebrospinal fluid (CSF) concentrations of neopterin, a putative marker of activated macrophages, in 97 subjects infected with human immunodeficiency virus type 1 who had a spectrum of neurological complications. The highest CSF neopterin concentrations occurred in those with neurological opportunistic infections, primary central nervous systems lymphoma, and acquired immunodeficiency syndrome (AIDS)dementia complex. In general, the CSF concentration of neopterin was independent of CSF cell count and blood-brain barrier disruption to albumin. In the patients with AIDS dementia complex, CSF neopterin concentrations correlated with severity of disease and decreased in conjunction with clinical improvement following treatment with zidovudine. ...

We previously reported that the human immunodeficiency virus type 1 NL4-3 Nef is necessary and sufficient to induce a severe AIDS-like disease in transgenic (Tg) mice when the protein is expressed under the regulatory sequences of the human CD4 gene. We have now assayed additional Nef alleles (SF2, JR-CSF, YU10x, and NL4-3 [T71R] Nef alleles), including some from long-term nonprogressors (AD-93, 032an, and 039nm alleles) in the same Tg system and compared their pathogenicities. All these Nef alleles downregulated cell surface CD4 in human cells in vitro and also, with the exception of NefYU10x, in Tg CD4+ T cells. Depletion of double-positive and single-positive thymocytes occurred with all alleles but was less pronounced in NefYU10x Tg mice. A loss of peripheral CD4+ T cells was observed with all alleles but was minimal in NefYU10x Tg mice. In Nef032an and NefSF2 Tg mice, T-cell loss was severe despite lower levels of Tg expression, suggesting a higher virulence of these alleles. All Nef ...

Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 mature virions. The gp300, which is a dimeric form of gp140, the precursor of HIV-2 envelope glycoprotein, is probably formed by a pH dependent fusion in the endoplasmic reticulum. Such a doublet is also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. On the other hand, the envelope glycoprotein precursor of HIV-1 does not form a dimer during its processing. Experiments carried out with various inhibitors of oligosaccharide trimming enzymes suggest that transient dimerization of the glycoprotein precursor is required for its efficient transport to the Golgi apparatus and for its processing. The gp300 is useful for detecting antibodies to

The MET oncogene represents an exciting therapeutic target in advanced NSCLC, with at least six MET TKIs currently in clinical development across the three different settings where genomic alterations suggest dependence upon oncogenic MET (Supplementary Table S2): de novo MET amplification, MET exon 14 skipping mutations, and MET amplification in resistance to EGFR TKIs. At least eight different combinations of MET and EGFR TKIs are being investigated in the context of EGFR TKI resistance. Our finding of a MET kinase domain mutation that leads to resistance to type I but not type II MET TKIs highlights the potential value of both classes of drugs in the management of NSCLC, as patients resistant to type I MET inhibitors may subsequently still respond to a type II MET inhibitor. Our findings are consistent with prior preclinical work using a mutagenesis-based resistance screen which found that MET mutations at D1228 cause resistance to NVP-BVU972 but not to AMG 458 (13).. This is not dissimilar ...

We have investigated whether the recently discovered transcription element, zinc little finger BED domain-containing proteins 6 (ZBED6), is expressed in insulin-producing cells and, if thus, to what degree it affects beta cell function. function of insulin-producing beta cells. For example, genetics code for transcription elements important to the pancreatic beta cellsuch as Neurog3, Nkx6.1, NeuroD2, and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA)were found to be putative joining focuses on for ZBED6 in myoblast cells (1). ZBED6-mediated control of may become relevant to beta cells because it offers been noticed that extravagant IGF2 creation in embryonic pancreas forwent the following beta cell mass anomaly that evolves in diabetic GotoCKakizaki rodents (3). Furthermore, the human being gene is usually clustered carefully collectively with (4), directing to the probability that not really just might become managed by a common ZBED6-reliant regulatory system. Therefore, it is ...

TY - JOUR. T1 - Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. AU - Yoon, Jong-Bok. AU - Li, Gen. AU - Roeder, Robert G.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - LBP-1 is a cellular protein which binds strongly to sequences around the human immunodeficiency virus type 1 (HIV-1) initiation site and weakly over the TATA box. We have previously shown that LBP-1 represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA box. Four similar but distinct cDNAs encoding LBP-1 (LBP-1a, -b, -c, and -d) have been isolated. These are products of two related genes, and each gene encodes two alternatively spliced products. Comparison of the amino acid sequence of LBP- 1 with entries in the available protein data bases revealed the identity of LBP-1c to α-CP2, an α-globin transcription factor. These proteins are also homologous to Drosophila melanogaster Elf-1/NTF-1, an essential transcriptional ...

A-myb, a conserved member of the Myb proto-oncogene family, encodes a sequence-specific DNA binding protein (A-Myb) that binds to and transactivates promoters containing myb-binding sites. Previous work has suggested that the C-terminus of A-Myb func

Sjögren's syndrome (SS) is an autoimmune disease in which exocrine tissues are affected by cellular and humoral immunity. As a result, the salivary and lacrimal glands of patients with SS are damaged, leading to xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Because experimental approaches to investigate SS pathogenesis in human patients are limited, development of a mouse model is indispensable for understanding the disease. In this study, we show that special AT-rich sequence binding protein-1 conditional knockout (SATB1cKO) mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop SS by 4 wk of age, soon after weaning ...

To better understand the extrarenal production of active vitamin D metabolites by cells of the monocyte/macrophage lineage, we investigated the 25-hydroxyvitamin D (25OHD)-1-hydroxylation reaction in the v-myc-transformed chick myelomonocytic cell line HD-11; the 1-hydroxylation reaction in this cell line has a high affinity for 25-hydroxylated vitamin D substrates, is localized to mitochondria, and is associated with cytochrome P450 activity. In this study we demonstrated that the HD-11 cell 1-hydroxylation reaction in vitro is not affected by the majority of extracellular regulatory factors that modulate expression of the renal 25OHD-1-hydroxylase in vivo. A 50% increase in extracellular calcium and phosphate concentrations, physiological inhibitory events for renal 1,25-dihydroxyvitamin D [1,25-(OH)2D] synthesis, did not decrease basal expression of the HD-11 cell 1-hydroxylation reaction, nor did a 50% decrease in extracellular calcium and phosphate concentrations, stimulatory signals for ...

We have investigated the molecular basis of biological differences observed among cell line-adapted isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) in response to receptor binding by using a soluble form of CD4 (sCD4) as a receptor mimic. We find that sCD4 binds to the envelope glycoproteins of all of the HIV-1 isolates tested with affinities within a threefold range, whereas those of the HIV-2 and SIV isolates have relative affinities for sCD4 two- to eightfold lower than those of HIV-1. Treatment of infected cells with sCD4 induced the dissociation of gp120 from gp41 and increased the exposure of a cryptic gp41 epitope on all of the HIV-1 isolates. By contrast, neither dissociation of the outer envelope glycoprotein nor increased exposure of the transmembrane glycoprotein was observed when sCD4 bound to HIV-2- or SIV-infected cells. Moreover, immunoprecipitation with sCD4 resulted in the coprecipitation of the surface and

PRIMARY OBJECTIVES:. I. To prospectively analyze the factors that are currently used for risk-group assignment (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog [MYCN] copy number by fluorescent in situ hybridization [FISH], deoxyribonucleic acid [DNA] content by flow cytometry, and tumor histology using the International Neuroblastoma Pathologic Classification System) in neuroblastoma tumors at the time of diagnosis.. II. To maintain a reference bank containing clinically and genetically characterized frozen tumor tissue, tumor DNA and ribonucleic acid (RNA), histology slides and paraffin blocks, neuroblastoma-derived cell lines, patient serum and paired normal DNA obtained at the time of diagnosis, at the time of second-look surgery and at the time of relapse for future research studies.. III. To prospectively analyze 1p, 11q, 14q and 17q allelic status, MYCN copy number by quantitative polymerase chain reaction (PCR); and the expression pattern of neurotrophin-related ...

The ENU-induced repro8 mutation was identified in a screen to uncover genes that control mouse gametogenesis. repro8 causes male-limited infertility, with failure of spermatocytes to exit meiotic prophase via the G2/MI transition. The repro8 mutation is in the Eif4g3 gene, encoding eukaryotic translation initiation factor 4, gamma 3. Mutant germ cells appear to execute events of meiotic prophase normally, and many proteins characteristic of the prophase-to-metaphase transition are not obviously depleted. However, activity of CDC2A (CDK1) kinase is dramatically reduced in mutant spermatocytes. Strikingly, HSPA2, a chaperone protein for CDC2A kinase, is absent in mutant spermatocytes in spite of the presence of Hspa2 transcript, consistent with the observation that the repro8 phenotype is markedly similar to the phenotype of the Hspa2 knockout. Thus, EIF4G3 is required for HSPA2 translation in spermatocytes, a finding that provides the first genetic evidence for selective translational control of meiotic

With the help of an expert Club Z! of McDonough chemistry tutor, even the most difficult chemistry concepts can be learned with ease. Whether you are learning the periodic table of elements or balancing chemical equations, tackling covalent bonds or just trying to memorize your bases and acids, an experienced chemistry tutor can help you achieve success. Our chemistry tutors are available for in-home or online tutoring, so you can start improving immediately in any of the following subject areas: High School Chemistry, Honors Chemistry, AP Chemistry, Chemistry homework help, Chemistry test preparation, Organic Chemistry, Chemical Compounds, Chemistry Labs, Chemical Bonds, Chemical Reactions.. Club Z!'s chemistry tutors are highly qualified and skilled in teaching all levels of chemistry. Our chemistry tutors use proven tutoring techniques to help their students build academic self-confidence and achieve positive results in the classroom. Don't just suffer through chemistry class. Call Club Z! of ...

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The effects of viral or activated cellular oncogenes on sensitivity to γ rays, ultraviolet light, and heat shock were examined in SHOK (Syrian hamster Osaka-Kanazawa) cells and their transfectants. Resistance to γ rays was conferred by the introduction of v-mos or c-cot genes, which coded serine/threonine kinase. Cells transfected with v-mos and c-cot genes increased their resistance to ultraviolet light and heat shock compared to their parent cells (SHOK cells). Of the activated ras genes, the N-ras gene developed a SHOK cell phenotype resistant to γ rays and ultraviolet light. The Ha-ras gene produced SHOK cells resistant to ultraviolet light and heat shock, while introduction of the Ki-ras gene did not affect sensitivity. The v-erbB gene was found to be involved in the development of resistance to heat shock. Transfection with neo, c-myc, and v-fgr genes had little or no effect on cell survival. The karyotypes of SHOK cells and oncogene-containing cells were compared. No alterations were ...

Oncogene Protein v-crk: A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.

c-Myc antibody (v-myc myelocytomatosis viral oncogene homolog (avian)) for ELISA, ICC/IF, IHC, WB. Anti-c-Myc pAb (GTX30518) is tested in Human, Chimpanzee samples. 100% Ab-Assurance.

Dr. John McDonough is married to Martha McDonough, D.O., a practicing family physician. They have two grown sons and four grandchildren. Their son John is a graduate of University of Colorado, is an Army veteran and businessman Golden, CO. Brian graduated from Winchester University and the Graduate School of Nursing at the Uniformed Services University. He is an active duty officer and serves as a Commander (0-5) in the United States Public Heath Service as a Family Nurse Practitioner. Dr. McDonough is an avid sailor and holds FAA ratings and certificates as a commercial pilot, instrument rated, single and multiengine, land ...

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), Authors: Lidia Larizza, Alessandro Beghini. Published in: Atlas Genet Cytogenet Oncol Haematol.

Myc oncogenes encode transcription factors that bind to E-box sequences in DNA, driving the expression of a large number of target genes and are deregulated in approximately 70% of human cancers. Deregulated Myc expression cause enhanced proliferation (which is counteracted by apoptosis), angiogenesis and cancer. Though Myc's importance in induction of S phase has been established, less is known about its functions in the G2 and M phases of the cell cycle. Paper I addresses the targeting of the Myc targets Aurora kinase A and B that have roles in G2/M transition and provide evidence that pharmaceutical Aurora kinase inhibition causes cell cycle arrest and apoptosis in a Myc-selective manner and is useful in treating Myc-induced lymphomas in vivo.. The assumption that the important target genes responsible for the biological effects of Myc overexpression were those encoding components of the cell cycle machinery lead to little interest in other potentially important groups of target genes. ...

The results of the RT-PCR assay and EMSA, shown in this study, have established that Bach2 functions in B cells as a major MARE‐binding factor. In terms of cell differentiation, B cell is the second hematopoietic cell lineage in which partners of MARE‐effectors have been identified, with a precedent being NF‐E2 p45 in erythroid cells (Andrews et al., 1993a, b; Igarashi et al., 1994). This is somewhat surprising in view of our previous observation that, among various hematopoietic cell lines tested, Bach2 expression was detected in the monocytic leukemic cell line M1 but not in BaF3 cells, which are supposed to have a pro‐B status (Oyake et al., 1996). However, in this study we examined Bach2 expression in primary B cells and in a large set of established B‐cell lines, and the results clearly indicate that Bach2 is in fact a B‐cell‐specific factor. The specific deployment of Bach2 in B cells suggests that Bach2 and its interacting bZip proteins are important regulators of B‐cell ...

A genomic sequence and cloned complementary DNA has been identified for a novel receptor-like gene of the PDGF receptor/CSF1 receptor subfamily (platelet-derived growth factor receptor/colony-stimulating factor type 1 receptor). The gene recognized a 6.4-kilobase transcript that was coexpressed in normal human tissues with the 5.3-kilobase PDGF receptor messenger RNA. Introduction of complementary DNA of the novel gene into COS-1 cells led to expression of proteins that were specifically detected with antiserum directed against a predicted peptide. When the new gene was transfected into COS-1 cells, a characteristic pattern of binding of the PDGF isoforms was observed, which was different from the pattern observed with the known PDGF receptor. Tyrosine phosphorylation of the receptor in response to the PDGF isoforms was also different from the known receptor. The new PDGF receptor gene was localized to chromosome 4q11-4q12. The existence of genes encoding two PDGF receptors that interact in a ...

3885 Medulloblastomas are malignant brain tumors that arise in the cerebellum in children. Aberrant activation of the Sonic Hedgehog (Shh) signaling pathway, which normally stimulates proliferation of granule neuron precursors (GNPs) during cerebellar development, induces tumors in mice that closely mimic human medulloblastomas. Shh-dependent medulloblastoma formation is enhanced by hyperactive insulin-like growth factor (IGF) signaling and ectopic expression of Myc oncogenes. This enhanced tumorigenesis stems from the sensitivity of GNPs to IGF and Myc levels in regulating proliferation. An emerging theme in cancer research is that oncogene-induced cell proliferation cannot initiate neoplastic transformation unless cellular programs that mediate apoptosis are disabled. We modeled the ability of the anti-apoptotic protein Bcl-2 to induce medulloblastoma in vivo using the RCAS/tv-a system, which allows postnatal gene transfer and expression in a cell type-specific manner. We targeted expression ...

In addition to FoxP3's role in regulatory T cell differentiation, multiple lines of evidence have indicated that FoxP3 play important roles in cancer development. Down-regulation of FoxP3 expression has been reported in tumour specimens derived from breast, prostate, and ovarian cancer patients, indicating that FoxP3 is a potential tumour suppressor gene. Expression of FoxP3 was also detected in tumour specimens derived from additional cancer types, including pancreatic, melanoma, liver, bladder, thyroid, cervical cancers. However, in these reports, no corresponding normal tissues was analyzed, therefore it remained unclear whether FoxP3 is a pro- or anti-tumourigeneic molecule in these tumours.[citation needed]. Two lines of functional evidence strongly supported that FoxP3 serves as tumour suppressive transcription factor in cancer development. First, FoxP3 represses expression of HER2, Skp2, SATB1 and MYC oncogenes and induces expression of tumour suppressor genes P21 and LATS2 in breast and ...

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What is the FMS? The FMS is a 7 movement test which helps us find body imbalances, limitations, and dangerous movement patterns so that they can be addressed. The FMS also indicates an individual's readiness to perform exercises so that realistic goals can be set and achieved.. How is the FMS Scored? Each of the 7 movements are worth a total of 3 points. The highest score someone can receive on their FMS is 21 and lowest is 0. As the trainer instructs you through each movement they look for faulty movement patters, balance issues, and any restrictions. If any pain is associated with the movement the participant will receive a score of 0 even if they complete the exercise perfectly. If no pain is associated with the movement then the score can range from as low as 1 to a perfect score of 3.. How is the FMS used? The FMS score is then applied to your Blueprint plan using specific exercises to correct and improve any movement issues. We do not take a "one size fits all" approach to our training. ...

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In nearly half of cancers, the anticancer activity of p53 protein is often impaired by the overexpressed oncoprotein Mdm2 and its homologue, MdmX, demanding efficient therapeutics to disrupt the aberrant p53-MdmX/Mdm2 interactions to restore the p53 activity. While many potent Mdm2-specific inhibitors have already undergone clinical investigations, searching for MdmX-specific inhibitors has become ...

A faulty MAF sensor in your Mercedes can seriously affect the performance of the car and lead to costly repairs. Here are the signs of a Faulty MAF sensor.

The human geography of Vietnam's upland area has been transformed significantly during the last 40 years due to the increasing control from the central government. We argue that State territorialisation, understood as a strategy of State-making and assertion of the State's authority, has the tendency to marginalise, socially and politically, local ethnic minority peoples by excluding them from indigenous social and economic geography and the use of natural resources. At the receiving end of these official policies, the local ethnic minority people do not passively accept their marginalisation but are able to initiate the use of traditional cross-border cultural resources to improve their condition. By analysing the tolerance from local official towards illicit cross-border activities daily carried out by local people, the case study provides some insights on the dynamics of power struggle between the State and local people. We concluded that local ethnic minority peoples actively re-negotiate with more