Men, women and children are suffering with the pain and the burning, itchy sensation that river blindness causes; everyone is susceptible to the disease. Parents are losing their vision and their ability to provide for their children. Children are distracted in school. At the forefront of preventable blindness, Lions knew they needed to step in and do what they could. Where there is a need, there is a Lion.. Since 1993, Lions Clubs International Foundation (LCIF) has awarded US$44.8 million to support the distribution of approximately 293 million treatments of Mectizan®, a river blindness medicine in 15 African and Latin American countries. SightFirst facilitated the training of more than one million community volunteers to distribute the medication. Working with the African Program for Onchocerciasis Control and the Onchocerciasis Elimination Program of the Americas initiatives, LCIFs partnerships are critical to these efforts to ensure that river blindness is no longer a public health ...
Scientists at the University of Liverpool have found that the worm which causes River Blindness survives by using a bacterium to provide energy, as well as help trick the bodys immune system into thinking it is fighting a different kind of infection.. River Blindness affects 37 million people, mainly in sub-Saharan Africa, causing intense itching of the skin, visual impairment and in severe cases, irreversible blindness. It is caused by a parasitic worm that is transmitted by blood-feeding blackflies, which breed in fast-flowing rivers.. The team at Liverpool investigated a bacteria carried by the worm, called Wolbachia, which if removed by antibiotics, kills the adult worm and cures River Blindness. To understand why the worms need these bacteria to survive, scientists sequenced the genome of Wolbachia from a closely related parasite in cattle.. They found that the bacteria could provide the worm with energy through a process that needs iron and oxygen, similar to cell energy processes in ...
Get information, facts, and pictures about river blindness at Encyclopedia.com. Make research projects and school reports about river blindness easy with credible articles from our FREE, online encyclopedia and dictionary.
On a warm spring day in the state of Chiapas, villagers in the small hamlet of Jose Maria de Morelos walk uphill on the towns only paved road to reach a small complex of school buildings. But today is not a school day; today, the river blindness elimination brigade is meeting at the school.. Inside, a Chiapas state health brigade worker measures the height of a squirmy boy about eight years old. The brigade worker then checks the boys head and shoulders for signs of nodules. These small, hard telltale bumps under the skin indicate the parasite that causes river blindness, also known as onchocerciasis, has infected its host. The boy has none. The brigade worker asks the boy if hes ever had any nodules, and the boy shakes his head, "No." The answer is common for his age.. Less than a generation ago, the answer almost surely would have been in the affirmative.. "There really has been change," says Guillevaldo Arriaga, a local village official and father of four. "The young people used to be ...
Its this fly that Moses Katabarwa, a Uganda native and senior epidemiologist for The Carter Centers River Blindness Program, has been chasing for more than 20 years. The black fly Simulium-about the size of a Georgia gnat-is unusual in its preference for moving water, since so many of its brethren pests like to breed in warm, stagnant puddles and ponds. Two different types of the fly carry the river blindness parasite, Onchocerca volvulus-one, S. damnosum, dives into flowing waters to lay its eggs, shooting them from its tiny body bundled in a superglue-like substance that sticks them firmly to underwater rocks or vegetation. The other, S. neavei, can lay eggs only in small river crabs and has a shorter flight range than its wily cousin ...
Definition of mesoendemic disease in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is mesoendemic disease? Meaning of mesoendemic disease as a legal term. What does mesoendemic disease mean in law?
A Muslim villager in Kaduna state allegedly helped Fulani herdsmen and other Muslims from nearby Kafanchan to ambush a Christian settlement, resulting in the death of one woman and gunshot wounds to two other Christians on Dec. 10, area sources said.
Such painful experiences resonate the buried and often unheard narratives of several sufferers of river blindness across the country.
All 30 River Blindness affected countries are being treated through a coalition spearheaded by the World Health Organization. Hope and Healing International is working with our partners to treat more than 16 million people with sight-saving, life-restoring Mectizan® each year.. By giving every person in an infected community Mectizan® for 10-15 years, we can ensure that no adult worms and larvae are left alive.. We couldnt do it without the great generosity of Merck and Co, without the cooperation of local Ministries of Health and without the dedication of local men and women, providing the frontline resources. ...
River blindness remains a major concern for parts of the world, especially in Africa and Latin America where up to 37 million people are infected. The disease causes eye and skin diseases. A new study offers a clue for eradication of the disease.
The more we know about this disease the better," agrees Juliet Fuhrman, who studies river blindness at Tufts University in Medford, Massachusetts. Wolbachias interaction with the immune system might provide a target for vaccines or other drugs to quell the disease itself, rather than the worms, Fuhrman hopes. "These may be our best chance," she says ...
One of the problems with river blindness is that it doesn't kill you. It's a nasty disease that causes agonizing itching, disfigured skin and, in
Its a major story for Africa. One of the biggest community-led medical campaigns, against the scourge of River Blindness, has scored a huge success. Now the...
10th May, 2018 By Yunusa Abdullahi According to Oral tradition, Nunguraya or Lunguda people are believed to have came from Gimai, they c ...
When Sofof came to work on the plantation he now manages, he explained to his new co-workers about the disease and the importance of taking Mectizan. "I remember one woman who, three years ago, refused to take her second treatment. I talked with her, and now she is one of the women who encourages people to take their medication. Another time, the people giving the drug told me that some workers did not take their medicine because they were in the field when it was administered. I went person to person, interrupting their work, and they took the medicine.". Sofof believes that if he can travel to other coffee plantations with people from Guatemalas ministry of health, he can increase the publics trust in health services. "My main hope is to keep clear vision," he says. "I want to thank all of you at The Carter Center because you come here to teach our people to teach the children how the disease is, how to prevent it, and how to cure it. Thank you very much.". ...
Two more areas and more than a million people in the country have met the World Health Organization criteria for elimination of the disease.
ÛÏGHTC is already a premiere venue for humanitarian technology. It is rapidly maturing and is on a trajectory to even greater things Û_ GHTC brings together diverse skills united by a heart to serve. The result is greater than the sum of its parts. Û Alexander Moseson, Drexel University, Unit ...
For decades, scientists suspected that the parasite responsible for river blindness might be causing a rare form of epilepsy. Now they have evidence.
Definition of optic nerve diseases in the Definitions.net dictionary. Meaning of optic nerve diseases. What does optic nerve diseases mean? Information and translations of optic nerve diseases in the most comprehensive dictionary definitions resource on the web.
Melanie Abongwa, a graduate assistant in biomedical sciences, collected plants in Cameroon that could lead to new treatments for river blindness. Photo courtesy of Melanie Abongwa. Larger image.. Melanie Abongwa, a graduate assistant in biomedical sciences in the ISU College of Veterinary Medicine who grew up in Cameroon, hopes that her research could help to alleviate the suffering caused by onchocerciasis, a disease sometimes called river blindness caused by parasitic worms. Theres no vaccine, nor is there an effective treatment to kill the adult worms that cause the disease. But Abongwa is studying a pair of plants native to Cameroon that rural residents have used to alleviate symptoms of the disease for years. Rural residents commonly turn to herbal remedies because of their limited access to modern medicine, but Abongwa said they have no scientific basis to claim how - or even if - the herbal treatments work.. "They dont know what kind of dose theyre taking, what in the plants is making ...
The World Health Organization (WHO) is concentrating on intervention techniques to reign in the occurrences of river blindness. They are targeting the areas where these blackflies breed and therefore multiply. Using larvicides in special sprays, these are sprayed around the breeding sites of the rivers which harbor the flies.. In addition, a drug called Ivermectin is often administered to those people who are infected with the parasitic worm transmitted from the blackfly which causes river blindness. This drug kills the young worms inside the body before they can truly become detrimental to a persons health. Both actions have helped lower the statistics of those affected by this tropical disease.. Photo: Onchocerca volvulus in its larval form. Image credit: CDC/Ladene Newto ...
Compare risks and benefits of common medications used for Onchocerciasis, River Blindness. Find the most popular drugs, view ratings, user reviews, and more...
Certara congratulates MDGH on submission of the moxidectin new drug application for the treatment of river blindness (onchocerciasis), a debilitating tropical disease.
The National Orientation Agency (NOA) in collaboration with the Green World Matters Limited has embarked on Operation keep your environment clean, in an attempt to boost cleanliness and inculcate the habit of frequent sanitation among the people of Kaduna State.. Speaking with journalists at the event, the chief operating officer of the Green World Matters Limited, Mrs. Ladi Faruk, said the essence of the exercise was to sensitise the public on the need to maintain a clean environment that can boost their health and the condition of the area.. "The environment has become very dirty. We asked for volunteers and they came out to participate in the cleaning exercise as you can see. Kaduna has become very dirty. I grew up here in Kaduna and it has never been this dirty. There is the need for environmental sanitation to be enforced because government alone cannot do it. We asked for change and it has come, but we need to participate if the change must become a reality. The Green World Matter ...
Contact: PATH: Claire Hudson, [email protected], 206.302.4521; SD/Alere: Jackie Lustig, [email protected], 781.314.4009.. Seattle and Seoul, April 11, 2016 - PATH and Standard Diagnostics (SD)/Alere announced today the commercial availability of two rapid diagnostic tools for onchocerciasis and lymphatic filariasis. Designed for use in disease surveillance, the antibody-based tests are part of a suite of diagnostic innovations intended to support the elimination of neglected tropical diseases (NTDs), a group of illnesses that affect more than a billion people worldwide.. Onchocerciasis, commonly known as river blindness, is caused by a parasitic worm transmitted to humans through the bite of the blackfly. It causes itching, skin disfiguration, and, with chronic exposure, permanent blindness. Globally, an estimated 169 million people are at risk for river blindness and 37 million are infected. Of those at risk, 99 percent live in Africa. The disease typically affects poor, rural communities ...
Learn about the causes, symptoms, diagnosis & treatment of Nematodes (Roundworms) from the Professional Version of the Merck Manuals.
The Sabin Vaccine Institute Product Development Partnership (Sabin PDP) recently became an advocate of The Onchocerciasis Vaccine for Africa (TOVA) Initiative, which is dedicated to creating a vaccine for onchocerciasis.
Abstract This study, made between November 1982 and January 1983 to ascertain the prevalence of onchocerciasis in the Babana District of Borgu Local Government Area, Kwara State, Nigeria, showed that 483 (48.6%) of the 993 subjects skin-snipped in 12 communities were infected. The infection rate was significantly higher (P < 0.001) for males (57.7%) than for females (37.0%), for subjects above 10 years of age (54.0%) than for those who were younger (10.7%), and for the Fulanis (63.8%) than for the Bokos (48.3%). Although various indications suggest that this district has a history of long-standing onchocerciasis, the knowledge of river blindness and its association with blackflies was poor throughout the district and, except for two teachers, no other subjects had ever received onchocercal chemotherapy. These factors, apparently, account for the frequent occurrence and severity of various clinical manifestations and complications of onchocerciasis identified in the district.
Although suppressive therapy for onchocerciasis with intermittent ivermectin prevents the development of pathology in endemic populations, the clinical and immunologic effects of therapy in the absence of continued exposure are unknown. To address this question, 14 patients treated with ivermectin for onchocerciasis acquired >10 years ago during temporary residence in Africa were reevaluated. None had evidence of continued infection or pathology at follow-up. Although eosinophilia, serum IgE, and antifilarial antibody levels decreased after ivermectin therapy, none of these parameters was useful in predicting the resolution of symptoms in infected patients. Peripheral blood mononuclear cells isolated from patients at follow-up were more responsive to parasite antigen in vitro, which is as assessed by proliferation and production of interferon-γ and interleukin (IL)-5. In contrast, antigen-induced levels of IL-10 were significantly decreased at follow-up, consistent with diminished ...
They were said to have gone after five youth suspected to be involved in the death of the herdsman.. This irked youth of Kadara community who launched a reprisal on Monday, leading to the deaths of 12 persons.. Salisu Mohammed, a witness, said after the attack, security agents were drafted to the affected communities and there was calm.ed, adding that things got out when the security personnel left as Kadara youths. Mohammed said things got out of control when the security personnel left. Youth from Kadara allegedly killed 10 people during another attack on their neighbours.. He said the victims were buried in a mass grave, and that during the burial, the news spread that nine more bodies had been recovered from the bush.. Yakubu Sabo, acting spokesman of the Kaduna state police command‎, confirmed that there were attacks in the area, but could not give details of the casualties.. Insecurity is one of the greatest challenges in Kaduna.. ...
The disease is caused by parasitic worms that are spread to humans through the bite of the black fly. The symptoms include itching so severe that those infected have been known to claw their skin off - or even commit suicide. The disease can also harden the eye tissue, leading to permanent blindness ...
Emodepside originates from the Japanese pharmaceutical company Astellas (TYO: 4503) and has been developed by Bayer HealthCares Animal Health division for veterinary use. The compound has been found to be effective in killing adult worms in preclinical studies, thus showing potential as a new macrofilaricidal drug for the treatment of patients with river blindness. Astellas has granted Bayer the rights to develop emodepside along these lines.. Large-scale programs for the treatment and control of filarial diseases, such as river blindness, have been in place for over 20 years, based on administering drugs to entire populations. While these mass drug administration (MDA) programs have seen considerable successes, treatments must be repeated at regular intervals of every six or 12 months for up to 17 years to cover the life span of adult worms. This is primarily due to the fact that currently used treatments are microfilaricidal, which means that they kill only the young worms. A ...
Kaiser, C, Kipp, W, Asaba, G, Mugisa, C, Kabagambe, G. et al. (‎1996)‎. The prevalence of epilepsy follows the distribution of onchocerciasis in a West Ugandan focus / C. Kaiser ... [‎et al.]‎. Bulletin of the World Health Organization 1996 ; 74(‎4)‎ : 361-367 https://apps.who.int/iris/handle/10665/54005 ...
He spoke through Kaduna State Governor, Mallam Nasir El-Rufai, at the inauguration of the EFCC zonal office in Kaduna.. Osinbajo said President Buhari resolved to work with Magu to prosecute his administrations anti-graft war.. Abdullah, in his Fridays reaction, said, "Senate has already made its resolution, and our resolutions are official statements. And most times, based on how we communicate. We dont go to press immediately because somebody has made a statement. We usually discuss issues. You know before we made that resolution the issue was debated. It is not because the executive has said something, we will react to it. We discuss issues first.. "He was brought to us for confirmation, and on the basis of damning reports from the DSS, we rejected him twice. It is left for Nigerians to see and we have done our part.". "We are expressing the opinion of the Senate, its stand and its position. We have given it a resolution. For now that is what subsists, and until we get a response, ...
The European Union Election Observation Mission (EU EOM) to Nigeria 2019 has said that the threat by the Kaduna State Governor, Nasir El-Rufai that foreign nationals who interfere in the forthcoming general elections would be given body bags treatment was not directed at EU Observers.
By examining the genomes of the worms and their symbiotic bacteria, the researchers were able to identify genes that coded for common proteins and molecular reactions essential to infection. 16 of the newly discovered proteins look promising as targets for existing drugs not currently used as treatments for river blindness, adding to the potential new medications for the disease. Further, the authors note, the protein data will accelerate development of new treatments for river blindness as well as other diseases associated with parasitic worm infections.. ###. Additional funding for one of the studies was provided in part by NIHs National Human Genome Research Institute.. ARTICLES: J Cotton et al. The genome of Onchocerca volvulus, agent of river blindness. Nature Microbiology DOI: 10.1038/NMICROBIOL.2016.216 (2016).. YJ Choi et al. Genomic Diversity in Onchocerca volvulus and its Wolbachia endosymbiont. Nature Microbiology DOI: 10.1038/NMICROBIOL.2016.207 (2016).. WHO: Thomas B. Nutman, M.D., ...
River Blindness, also known as Onchocerciasis, is caused by the Onchocerca volvulus worm which is transmitted from person to person by daytime biting infected blackflies belonging to the genus Simulium damnosum. Infective larval worms (microfilariae) develop in the blackfly and once injected into humans through a blood meal, the worms form nodules, reproduce, and migrate to subcutaneous tissue where they can be ingested by blackflies to continue the infectious cycle. The intensity of the illness is related to the number of bites sustained. River Blindness is a Neglected Tropical Disease (NTD)*.. * Neglected Tropical Diseases are chronic infections that are typically endemic in low income countries. They prevent affected adults and children from going to school, working, or fully participating in community life, contributing to stigma and the cycle of poverty. ...
Black flies, turkey gnats or "White Socks" as some are colloquially known as in parts of the U.S. are a family of biting flies belonging to the Simuliidae family in the world of the Diptera or true flies. The Simulium genus is by far the most well-known genus as many of its 700+ members (sounds like Im addressing a convention of critters) transmit infectious diseases such as river blindness or Onchocerciasis (Gregors affiliated charity Fighting Blindness will be all but too aware of this horrible disease), bovine Onchocerciasis (cattle blindness) and leucocytozoonosis (an immuno-compromising infection leading to gauntness and emaciation in wild birds). The "White Socks" include Simulium venustum amongst other members within the Simulium genus and are also known as "White stocking" flies because of the rather evident bands of white coursing the legs of individuals. These flies do not spread the majority of the above mentioned infectious diseases nor do the species that reside within the British ...
O 1999 Ifremer/Cnrs/Inra/Cemagref~ditions scientifiques et médicales Elsevier SAS. Tous droits réservés S /FLA Onchocerciasis Control Programme in West Africa: a 20-year monitoring
Optic Nerve Diseases symptoms, causes, diagnosis, and treatment information for Optic Nerve Diseases (Optic nerve disorder) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
t is currently unknown what causes the disease, but it is believed to be connected to infestations of the parasitic worm Onchocerca volvulus, which is prevalent in all outbreak areas.[10] O. volvulus, a nematode, is carried by the black fly and causes river blindness. In 2004, most children suffering from nodding disease lived close to the Yei River, a hotbed for river blindness, and 93,7% of nodding disease sufferers were found to harbor the parasite--a far higher percentage than in children without the disease.[11] A link between river blindness and normal cases of epilepsy,[12] as well as retarded growth,[13] had been proposed previously, although the evidence for this link is inconclusive.[14] Of the connection between the worm and the disease, Scott Dowell, the lead investigator into the syndrome for the US Centers for Disease Control and Prevention (CDC), stated: "We know that [Onchocerca volvulus] is involved in some way, but it is a little puzzling because [the worm] is fairly common in ...
With the aim to understand how next-generation sequencing (NGS) improves both our assessment of genetic variation within populations and our knowledge on HLA molecular evolution, we sequenced and analysed 8 HLA loci in a well-documented population from sub-Saharan Africa (Mandenka). The results of full-gene NGS-MiSeq sequencing compared with those obtained by traditional typing techniques or limited sequencing strategies showed that segregating sites located outside exon 2 are crucial to describe not only class I but also class II population diversity. A comprehensive analysis of exons 2, 3, 4 and 5 nucleotide diversity at the 8 HLA loci revealed remarkable differences among these gene regions, notably a greater variation concentrated in the antigen recognition sites of class I exons 3 and some class II exons 2, likely associated with their peptide-presentation function, a lower diversity of HLA-C exon 3, possibly related to its role as a KIR ligand, and a peculiar molecular diversity of HLA-A ...
The Kaduna State chapter of the All Progressives Congress (APC) on Friday declared that the party has no faction saying its leadership and members stand united with Governor Nasir el-Rufai in delivering service to the masses. It would be recalled that, the Senator representing Kaduna Central Senatorial District, under APC, Shehu...News, Express, politics, religion, federal government, Nigeria
NTDs are not simply neglected in terms of awareness and resource allocation but also in the sense that they affect some of the most neglected communities on the planet - those at the end of the road, those for whom fresh water and hygiene are challenging and those whose access to the health care is limited.. In fact, diseases such as river blindness, elephantiasis, trachoma, bilharzia, and various types of worms are so closely linked with poverty that they can be used as effective indicators to gauge the success of health systems in terms of equity.. Last month, I joined a panel in Washington D.C. to discuss the launch of a new report, The Economic Case for Neglected Tropical Disease Control and Elimination [1]from the Hudson Institute and the Global Network for NTDs. The report cites investment in NTDs-which include onchocerciasis (river blindness), elephantiasis (filarial) as one of the "best buys" in public health, offering a highly cost-effective intervention with far-reaching macroeconomic ...
The Kastina state Commissioner of Health, Mariyatu Bala Usman has disclosed that a middle-aged man (name withheld), brother of a man who died from Lassa fever and seven others who participated in the burial rites have tested positive to Lassa fever in Kastina State, Northwest Nigeria.. They are now being quarantined at the National Obstetric Fistula Centre at Babbar Ruga.. The Director of Public Health, Dr. Shamsudden Yahaya said that about 18 primary contacts of the diseased had been quarantined just as over 100 secondary contacts were closely being monitored and are on drugs.. ...
This year marks the 10th anniversary of Colorado Gives Day, a statewide movement to celebrate and increase philanthropy in our state. Colorado Public Radio is proud to be a part of this nonprofit community. Were in good company so were highlighting nonprofits doing great work. ...
The Kaduna State House of Assembly on Friday passed the Religious Preaching Regulation bill into law. The new Religious Preaching Regulation law s...
Geograpical investigations have made a substantial contribution to knowledge about the major tropical endemic diseases since the onchocerciasis (river blindness) control programme was set in place in 1975. Closely hinged on multidisciplinary work with biologists and medical practioners, theses studies showed the importance of land management by societies related to the outbreak, diffusion and propagation of such endemic diseases. This approach deploys a set of multiple-scale spatial and temporal anlyses, helping to refine a set of concepts which have become key tools for evaluating the potential epidemic-generating capacity of certain places. A multiplication of models for different environments has contributed to enhanced knowledge of situations and processes and an improved theoretical grasp of what happens. However, in spite of such advances in biogeographical knowledge of diseases -and especially those achieved in therapy and control- the public health situation has hardly seen any ...
A French engineer kidnapped in northern Nigeria 11 months ago says he escaped his captors on a motorcycle, without a ransom being paid, and will return to France immediately. Kaduna State Police...