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High-quality Olfactory marker protein proteins from ACROBiosystems. Various species and tags of Olfactory marker protein proteins. Minimal Batch-to-Batch Variation. Bulks in stock.

Recombinant Human Olfactory Marker Protein/OMP is an Escherichia coli Full length protein 1 to 163 aa range, | 95% purity and validated in SDS-PAGE, MS.

Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Arsenic atom in PDB 1jod: Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P43212

Multiple factors contribute to the onset and progress of PD, that initially targets few susceptible neuron types in motor nuclei of glossopharyngeal and vagus nerves, and in the anterior olfactory nucleus [2, 3, 24]. Many animal models are available for mimicking PD landmarks, however none can reproduce in full the human pathology. The picture is even more complicated by the presence of both motor and non-motor symptoms, whose assessment in animal models may be difficult and need careful overall interpretation (for a review, see [25]). We choose the MPTP model because we were interested in olfactory dysfunctions, which are a hallmark of early PD stages. MPTP administered acutely in mice can reproduce early stages of PD [26], however, it is not sufficient for fully exploring PD, since MPTP-injected mice recover spontaneously, which precludes the study of pharmacological interventions. Moreover, various strains of mice show different sensitivity to MPTP.. PD implies a complex imbalance of the ...

Both the olfactory and vomeronasal pathways are neuronal systems in which the sensory neurons are thought to be capable of continuous replenishment and re-innervation of their central targets...

The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimers disease (AD). Clinical development of BACE1 inhibitors is being intensely pursued. However, little is known about the physiological functions of BACE1, and the possibility exists that BACE1 inhibition may cause mechanism-based side effects. Indeed, BACE1-/- mice exhibit a complex neurological phenotype. Interestingly, BACE1 co-localizes with presynaptic neuronal markers, indicating a role in axons and/or terminals. Moreover, recent studies suggest axon guidance molecules are potential BACE1 substrates. Here, we used a genetic approach to investigate the function of BACE1 in axon guidance of olfactory sensory neurons (OSNs), a well-studied model of axon targeting in vivo. We bred BACE1-/- mice with gene-targeted mice in which GFP is expressed from the loci of two odorant-receptors (ORs), MOR23 and M72, and olfactory marker protein (OMP)

To explore interactions between respiration, inhibition, and olfaction, experiments using light to active channel rhodopsin in sensory neurons expressing Olfactory Marker Protein were performed in mice and modeled in silico. This archive contains NEURON models that were run on parallel computers to explore the interactions between varying strengths of respiratory activity and olfactory sensory neuron input and the roles of periglomerular, granule, and external tufted cells in shaping mitral cell responses ...

To explore interactions between respiration, inhibition, and olfaction, experiments using light to active channel rhodopsin in sensory neurons expressing Olfactory Marker Protein were performed in mice and modeled in silico. This archive contains NEURON models that were run on parallel computers to explore the interactions between varying strengths of respiratory activity and olfactory sensory neuron input and the roles of periglomerular, granule, and external tufted cells in shaping mitral cell responses ...

Blended electrophysiological, biochemical, and behavioral experiments, Minghong Ma, PhD, an associate Professor of Neuroscience at the University of Pennsylvania School of Medicine, led a study published in a recent issue of the Journal of Neuroscience. With students Anderson Lee and Jiwei He, she demonstrated that neurons in the noses of mice mature after birth. Using patch-clamping - a technique that measures electrical signals at the cellular level - Mas team found that between birth and day 30 of development, normal neurons become six times more sensitive to their siblings scent, in this case, a fragrance called lyral. In addition, the mice transition from a relative indiscriminate response to different odors to being highly attuned to one specific smell. They also respond to that specific odor with a faster speed over time. The olfactory marker protein (OMP) likely mediates this developmental maturation. In olfactory sensory neurons lacking OMPs, response fails to speed up over 30 days as ...

1. Buck L and Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65 (1):175-187. 2. Greer PL, Bear DM, Lassance JM, Bloom ML, Tsukahara T, Pashkovski SL, Masuda FK, Nowlan AC, Kirchner R, Hoekstra HE, and Datta SR (2016) A Family of non-GPCR chemosensors defines an alternative logic for mammalian olfaction. Cell 165 (7):1734-1748. 3. Busse D, Kudella P, Gruning NM, Gisselmann G, Stander S, Luger T, Jacobsen F, Steinstrasser L, Paus R, Gkogkolou P, Bohm M, Hatt H, and Benecke H (2014) A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. J Invest Dermatol 134 (11):2823-2832. 4. Pavlath GK (2010) A new function for odorant receptors: MOR23 is necessary for normal tissue repair in skeletal muscle. Cell Adh Migr 4 (4):502-506. 5. Kang N, Kim H, Jae Y, Lee N, Ku CR, Margolis F, Lee EJ, Bahk YY, Kim MS, and Koo J (2015) Olfactory marker protein expression is an indicator of ...

A recent study from The Monell Center found the connection between the olfactory marker protein (OMP) and the detection of different scents after a 30-year-old mystery.

Kaufmann-Peterson [base]; Keratitic Precipitate; Keratitis Punctata; Kidney Protein; Killed Parenteral [vaccine]; Klebsiella ...

Fly culture and transgenic lines. Drosophila melanogaster Canton S-5 (CS-5), the parental wild-type strain from which acj6 mutants were derived (McKenna et al., 1989), were reared at 18 or 25°C on cornmeal, sucrose, yeast media.. The olfactory neuron-specific P [Gal4] driver line GH86 (Heimbeck et al., 1999) and the UAS-Acj6 (1,3,4) and UAS-Acj6 (1,4) (Certel et al., 2000) responder lines were obtained from Dr. W. A. Johnson (University of Iowa). UAS-Acj6 (1,3,4) (chromosome II) and UAS-Acj6 (1,4) (chromosome III) transgenic lines (Certel et al., 2000) were recombined with Cha-Gal4 lines (chromosome III or II) by standard genetic crosses using second or third chromosome balancers,CyO or TM3. The GH86 olfactory driver was recombined with either UAS-Acj6 (1,3,4) or UAS-Acj6 (1,4) transgenic lines, and male progeny were used for ChAT assay (see below).. A fluorescent cholinergic reporter line marking essentially all known cholinergic neurons consisted of a 7.4 kb Cha-Gal4 driver line (19B) ...

We show here that inhibition of retinoid signaling selectively in OSNs in vivo results in death of mature OSNs subsequent to the development of the olfactory sensory map. One important implication of this result is that it is possible to experimentally separate a retinoid-regulated survival mechanism that operates at a late stage of neural circuit formation, or during maintenance of established connections, from retinoid-regulated mechanisms that influence survival of neurons during early stages, e.g., during neurogenesis, establishment of neuronal identity, and formation of precise axonal projection patterns (Sockanathan et al., 2003; Wang et al., 2005). This finding is particularly relevant in light of studies that have demonstrated a fundamental role of retinoid signaling for the maintenance of mature brain function (Chiang et al., 1998; Etchamendy et al., 2001; Misner et al., 2001; Goodman and Pardee, 2003). It is also noteworthy that studies have shown that the amyloid precursor protein, ...

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Researchers have developed a new technology that makes use of antibodies linked to unique DNA barcodes that can be used to simultaneously analyze hundreds of cancer-related protein markers.

Blood groups are classified according to different marker proteins on the surface of red blood cells. These marker proteins called antigens...

Normal apoptosis occurs continuously in the olfactory neuroepithelium of adult vertebrates, making it a useful model for studying neuronal apoptosis. Here we demonstrate that overexpression of the anti-apoptotic Bag-1 gene in olfactory neuronal cells confers a strong resistance to apoptosis. Conversely decreased levels of Bag-1 were found to precede a massive wave of olfactory neuronal apoptosis triggered by synaptic target ablation. We show that the decrease is brought about by ubiquitination and subsequent degradation of the Bag-1 protein. The ring finger protein Siah-2 is a likely candidate for the ubiquitination reaction since Siah-2 mRNA accumulated in lesioned olfactory neuroepithelium and overexpression of Siah-2 stimulated Bag-1 ubiquitination and degradation in transient expression assays. These results together identify destabilization of Bag-1 as a necessary step in olfactory neuronal apoptosis. ...

TY - JOUR. T1 - The senescence marker protein (SMP-2) of the rat liver. T2 - purification, immunochemical characterization and age-dependent regulation. AU - Chatterjee, Bandana. AU - Mancini, Michael A.. AU - Roy, Arun K.. N1 - Funding Information: The work was supportedb y NIH grant AG-03527. A.K.R. is the recipient of a MERIT Award from NIDDK. We thank MasarratA li, Richard Lorch and C.V.R. Murty for their contributiontso this work.. PY - 1990/5/16. Y1 - 1990/5/16. N2 - In vitro translation of total rat hepatic mRNAs has identified a 31 kilodalton senescence marker protein (SMP-2) which is present in higher amounts in prepubertal and senescent males than in the post-pubertal adult male (more than 10-fold). SMP-2 is an androgen-repressible protein. The negative regulation of the SMP-2 gene activity by androgen accounts for its increased expression during the androgen insensitive states of the prepubertal and senescent livers, and its constitutive expresion in the female liver. A combination of ...

Margolis, F. L., Kudrycki, K., Stein-Izsak, C., Grillo, M. and Akeson, R. (2007) From Genotype to Olfactory Neuron Phenotype: The Role of the Olf-1-Binding Site, in Ciba Foundation Symposium 179 - The Molecular Basis of Smell and Taste Transduction (eds D. Chadwick, J. Marsh and J. Goode), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514511.ch2 ...

PLASTIC SCALE FILE CABINETS Use for office planning or architectural models. May also be used to add extra detail to your model railroad layout building interiors. Minimal assembly required on some items. Precision Injection Molded in Styrene Plastic or fabricated from Acrylic Plastic. UPC Package Quantity represents t

Huaiyang Chen is the author of this article in the Journal of Visualized Experiments: Lentivirus-mediated Genetic Manipulation and Visualization of Olfactory Sensory Neurons in vivo

The gene product of the cytoadherence-linked asexual gene 9 (clag9) (64) was used as a second rhoptry-specific marker. CLAG9 was previously localized exclusively to the bulb of the rhoptry (31). The distribution of CLAG9 predominantly overlaps with that of RALP1 (Fig. 5B). In contrast, the apical distribution of RALP1 was clearly distinct from that of the micronemal marker proteins EBA-175 and EBA-181 (19, 53) (Fig. 5C and D). Together, these findings establish RALP1 as a novel rhoptry-resident protein. ...

The gene product of the cytoadherence-linked asexual gene 9 (clag9) (64) was used as a second rhoptry-specific marker. CLAG9 was previously localized exclusively to the bulb of the rhoptry (31). The distribution of CLAG9 predominantly overlaps with that of RALP1 (Fig. 5B). In contrast, the apical distribution of RALP1 was clearly distinct from that of the micronemal marker proteins EBA-175 and EBA-181 (19, 53) (Fig. 5C and D). Together, these findings establish RALP1 as a novel rhoptry-resident protein. ...

Fingerprint Dive into the research topics of Radial glia interact with primary olfactory axons to regulate development of the olfactory bulb. Together they form a unique fingerprint. ...

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Olfactory Nerve Definition Also called as CN1, the olfactory nerve is among the first of 12 cranial nerves situated in the head. It transmits sensory data to

The olfactory epithelium is an area inside the nose that intercepts odors and passes them on to the brain. Though its not totally...

You are viewing an interactive 3D depiction of the molecule 5-(6-oxo-3,6-dihydro-9h-purin-9-yl)-2,3-pentanedione (C10H17N4O3+) from the PQR.

A model of efficient coding by olfactory neurons explains context-dependence observed in the effect of perturbations to the olfactory environment.

ICD-10-PCS code 00NF3ZZ for Release Olfactory Nerve, Percutaneous Approach is a medical classification as listed by WHO under the range - Central Nerv

Copyright remains with the authors 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 (CC BY-NC-SA 3.0) License which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one ...

Nasal region of small mammal (mouse or rat), t.s. showing respiratory and olfactory epithelium, bone etc. prepared microscope slide. Product code: MSMA0211

Synonyms for olfactory cell in Free Thesaurus. Antonyms for olfactory cell. 24 synonyms for cell: room, chamber, lock-up, compartment, cavity, cubicle, dungeon, stall, unit, group, section, core, nucleus, caucus, coterie, electric cell. What are synonyms for olfactory cell?

Definition of olfactory property in the Definitions.net dictionary. Meaning of olfactory property. What does olfactory property mean? Information and translations of olfactory property in the most comprehensive dictionary definitions resource on the web.

Following total, unilateral bulbectomy in neonatal mice, the olfactory sensory axons regrow from a reconstituted population of sensory neurons, cross the lamina cribrosa, and invade the spared forebrain that has leaned forward toward the anteroventral wall of the cranial cavity. The sensory axons in …

ICD-10-PCS code 00NF4ZZ for Release Olfactory Nerve, Percutaneous Endoscopic Approach is a medical classification as listed by WHO under the range - C

Recombinant Olfactory Receptor 480 (Olfr480) Protein (rho-1D4 tag). Spezies: Maus. Quelle: Insektenzellen. Jetzt Produkt ABIN3127107 bestellen.

DUGi: Viewing Item from repository Recercat: Model-free isoconversional method applied to polymer crystallization governed by the Hoffman-Lauritzen kinetics

Olfactory ensheathing cells (OECs) are the glial cells of the olfactory system. Their primary role is thought to be to provide support and guidance for primary olfactory axons. However, OECs are known to phagocytose bacteria and express immune markers and thus they may help to maintain a healthy environment. Interestingly, following widespread death of primary olfactory axons, there is minimal mobilisation of macrophages but yet the axonal debris is rapidly cleared. Purpose: We have therefore investigated whether OECs are the cells that are primarily responsible for removal of axonal debris. Methods: We cultured red fluorescent OECs from S100beta-DsRed mice and green fluorescent primary olfactory neurons from OMP-ZsGreen mice. Results: In explant cultures of DsRed-OECs and ZsGreen-neurons, OECs clearly contained green fluorescent axonal debris. When cellular debris from green fluorescent neurons was added to cultured OECs, the OECs extended pseudopodia and rapidly phagocytosed the axonal debris ...

Human OR51E2 / Olfactory receptor 51E2 ELISA Kit from ELISA Genie is a pre-coated immunoassay with a sensitivity of 0.094 ng/ml and a range of 0.156-10ng/ml and has been designed to measure Human OR51E2 / Olfactory receptor 51E2 ELISA Kit in serum, plasma & cell culture supernatant samples. The Human OR51E2 / Olfactory receptor 51E2 ELISA Kit accurately measures natural Human OR51E2 / Olfactory receptor 51E2 levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human OR51E2 / Olfactory receptor 51E2 peptide.

TY - JOUR. T1 - Cloning of a novel Olf-1/EBF-like gene, O/E-4, by Degenerate Oligo-based Direct Selection. AU - Wang, Song S.. AU - Betz, Alexander G.. AU - Reed, Randall R. PY - 2002. Y1 - 2002. N2 - The Olf-1/EBF (O/E) family of transcription factors plays important roles in neural development and B-cell maturation. We have utilized a variation of the direct selection scheme (Degenerate Oligo-based Direct Selection, or DODS) to identify a fourth member of the O/E family (O/E-4). We demonstrated that, similar to previously identified mouse O/E proteins, O/E-4 is expressed in the neuronal and basal cell layers of mouse olfactory epithelium. However, unlike other O/E members, O/E-4 expression is absent in the vomeronasal organ. O/E-4 can partner with the other O/Es to form heterodimers that are capable of binding an Olf-1 consensus site in vitro. In contrast to other O/E family members, the O/E-4 protein only weakly activates transcription in a reporter assay. In summary, we have identified O/E-4 ...

Under the conditions of this study, inhalation exposure to MEKO at concentrations of 10, 30 or 100 ppm for 6 hours/day, 5 day/week for 13 weeks produced minimal to moderately severe olfactory epithelium degeneration in male CD-1 mice. The incidence and severity of the degeneration was concentration dependent and not progressive over time with continued exposure. The lesions were localized to the olfactory epithelium lining the dorsal meatus in the anterior portion of the nasal cavity. Large areas of olfactory epithelium laterally and posteriorly appeared unaffected. No effects to olfactory epiithelium were found at 30 ppm MEKO in > 50% of the animals, indicating that only the most sensitive animals responded at this relatively high level of exposure. The degeneration of the olfactory epithelium following exposure to MEKO is not widespread but limited primarily to cells in the dorsal anterior portion of the nasal cavity. This represents approximately 10% of the olfactory epithelium lining the ...

In the mouse, each class of olfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to two specific glomeruli in the olfactory bulb, thereby creating an odour map. However, it is unclear how this map is represented in the olfactory cortex. Here we combine rab …

Olfactory nerve definition, either one of the first pair of cranial nerves, consisting of sensory fibers that conduct to the brain the impulses from the mucous membranes of the nose. See more.

Pages that link to Paper - The development of the olfactory and the accessory olfactory formations in human embryos and fetuses ...

Olfactory receptors interact with odorant molecules in the nose, to initiate a neurol response that triggers the perception of a smell. The olfactory…

J:190657 Cho JH, Kam JW, Cloutier JF, Slits and Robo-2 regulate the coalescence of subsets of olfactory sensory neuron axons within the ventral region of the olfactory bulb. Dev Biol. 2012 Nov 15;371(2):269-79 ...

OR5AS1 (olfactory receptor family 5 subfamily AS member 1), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.

integral component of membrane, olfactory receptor activity, G protein-coupled receptor signaling pathway, sensory perception of smell

integral component of membrane, olfactory receptor activity, G protein-coupled receptor signaling pathway, sensory perception of smell

OR52A5 (olfactory receptor family 52 subfamily A member 5), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.

Ito yung responsable sa pang-amoy natin. Ano nga bang mensahe ng bawat amoy? Bukod sa amoy ng tsismis na siguradong may mensahe, bawat amoy ay may konteksto. Na pwedeng pagsimulan ng rebolusyon? Naalala ko nung 4th year high school, minsan naitanong ng guro namin sa Filipino ang tungkol sa ipinapasang ordinansa kaugnay sa may mga…

Specialized treatment of Olfactory Reference Syndrome (ORS), also known as Autodysomophobia or Bromosis. Serving clients in California and internationally

Take this free online Olfactory Reference Syndrome test from the OCD Center of Los Angeles. Serving clients in California and internationally.