The UPSIT involves 40 microencapsulated odors in a scratch-and-sniff format, with 4 response alternatives accompanying each odor. The patient takes the test alone, with instructions to guess if not ab... more
However, two 2016 studies support the use of the University of Pennsylvania Smell Identification Test (UPSIT), and suggest it may offer a practical, low-cost alternative to other tests.. In one study, UPSIT was administered to 397 older adults (average age 80) without dementia, who were also given an MRI scan to measure the thickness of the entorhinal cortex (the first brain region to be affected by Alzheimers disease). After four years, 50 participants (12.6%) had developed dementia, and nearly 20% had signs of cognitive decline.. Low UPSIT scores, but not entorhinal cortical thickness, were significantly associated with dementia and Alzheimers disease, and with cognitive impairment. Entorhinal cortical thickness was significantly associated with UPSIT score in those who transitioned from MCI to dementia.. In other words, it looks like impairment in odor identification precedes thinning in the entorhinal cortex.. In another study, UPSITwas administered to 84 older adults, of whom 58 had MCI, ...
However, two 2016 studies support the use of the University of Pennsylvania Smell Identification Test (UPSIT), and suggest it may offer a practical, low-cost alternative to other tests.. In one study, UPSIT was administered to 397 older adults (average age 80) without dementia, who were also given an MRI scan to measure the thickness of the entorhinal cortex (the first brain region to be affected by Alzheimers disease). After four years, 50 participants (12.6%) had developed dementia, and nearly 20% had signs of cognitive decline.. Low UPSIT scores, but not entorhinal cortical thickness, were significantly associated with dementia and Alzheimers disease, and with cognitive impairment. Entorhinal cortical thickness was significantly associated with UPSIT score in those who transitioned from MCI to dementia.. In other words, it looks like impairment in odor identification precedes thinning in the entorhinal cortex.. In another study, UPSITwas administered to 84 older adults, of whom 58 had MCI, ...
Olfactory identification deficits occur in patients with Alzheimers disease (AD), are associated with disease severity, predict conversion from mild cognitive impairment (MCI) to AD and are associated with healthy elderly subjects developing MCI. Odor (olfactory) identification deficits may reflect degeneration of cholinergic inputs to the olfactory bulb and other olfactory brain regions. Acetylcholinesterase inhibitors (ACheI) like donepezil show modest effects in improving cognition but can be associated with adverse effects and increased burden and costs because of the need for prolonged, often lifelong, treatment. Converging findings on odor identification test performance (UPSIT, scratch and sniff 40-item test) from four pilot studies, including two of our own, suggest that acute change in the UPSIT in response to an anticholinergic challenge (atropine nasal spray), incremental change over 8 weeks, and even the baseline UPSIT score by itself, may predict cognitive improvement with ACheI ...
Methods: In 274 members of the PREVENT-AD cohort of healthy aging persons with a parental or multiple-sibling history of AD dementia, we assessed the cross-sectional association of OI with potential indicators of presymptomatic AD. Some 101 participants donated CSF, thus enabling assessment of AD pathology with the biomarkers total tau (t-tau), phospho-tau (P181-tau), and their ratios with β-amyloid (Aβ1-42). Adjusted analyses considered age, cognition, APOE ε4 status, education, and sex as covariates. We measured OI using the University of Pennsylvania Smell Identification Test and cognitive performance using the Repeatable Battery for Assessment of Neuropsychological Status. Standard kits provided assays of the AD biomarkers. Analyses used robust-fit linear regression models. ...
Many previous studies have reported robust sex differences in olfactory perception. However, both men and women can be expected to vary in the degree to which they exhibit olfactory performance considered typical of their own or the opposite sex. Sex-atypicality is often described in terms of childhood gender nonconformity, which, however, is not a perfect correlate of non-heterosexual orientation. Here we explored intrasexual variability in psychophysical olfactory performance in a sample of 156 individuals (83 non-heterosexual) and found the lowest odor identification scores in heterosexual men. However, when childhood gender nonconformity was entered in the model along with sexual orientation, better odor identification scores were exhibited by gender-nonconforming men, and greater olfactory sensitivity by gender-conforming women, irrespective of their sexual orientation. Thus, sex-atypicality, but not sexual orientation predicts olfactory performance, and we propose that this might not be limited to
Introduction: Fibrous dysplasia is a relatively common disorder of bones. However, cranial fibrous dysplasia comprise less than one percent of all primary bone lesions. Although a variety of clinical manifestations exists, olfactory dysfunction as the presenting symptom is very rare.. Case Report: We present a 72-year-old female patient with a 3-year history of olfactory dysfunction and chronic rhinosinusitis. Clinical examination including nasal endoscopy revealed polypoid middle meatal mucosa. Psychophysical testing using Sniffing Sticks battery showed severe hyposmia. The patient received a course of oral corticosteroids without any improvement. Further investigations included computed tomography and magnetic resonance imaging of the brain. Bony lesions of the right temporal and sphenoid bone with extension to the cavernous sinus were found. Imaging findings were characteristic of polyostotic type fibrous dysplasia. Plain x-rays of skeletal bones did not show other lesions. Localization of ...
The main clinical manifestations of the spinocerebellar ataxias (SCAs) result from the involvement of the cerebellum and its connections. Cerebellar activity has been consistently observed in functional imaging studies of olfaction, but the anatomical pathways responsible for this connection have not yet been elucidated. Previous studies have demonstrated olfactory deficit in SCA2, Friedreichs ataxia and in small groups of ataxia of diverse aetiology. The authors used a validated version of the 16-item smell identification test from Sniffin Sticks (SS-16) was used to evaluate 37 patients with genetically determined autosomal dominant ataxia, and 31 with familial ataxia of unknown genetic basis. This data was also compared with results in 106 Parkinsons disease patients and 218 healthy controls. The SS-16 score was significantly lower in ataxia than in the control group (p,0.001, 95% CI for β=0.55 to 1.90) and significantly higher in ataxia than in Parkinsons disease (p,0.001, 95% CI for ...
The impact of health, management, and microbiota on olfactory function in canines has not been examined in review. The most important characteristic of the detection canine is its sense of smell. Olfactory receptors are primarily located on the ethmoturbinates of the nasal cavity. The vomeronasal organ is an additional site of odor detection that detects chemical signals that stimulate behavioral and/or physiological changes. Recent advances in the genetics of olfaction suggest that genetic changes, along with the unique anatomy and airflow of the canine nose, are responsible for the macrosmia of the species. Inflammation, alterations in blood flow and hydration, and systemic diseases alter olfaction and may impact working efficiency of detection canines. The scientific literature contains abundant information on the potential impact of pharmaceuticals on olfaction in humans, but only steroids, antibiotics, and anesthetic agents have been studied in the canine. Physical stressors including exercise,
List of causes of Dark circles under eyes and Eyelid symptoms and Olfactory dysfunction, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Of all our senses, smell is the most mysterious. Yet, despite our lack of understanding, it seems that the nose knows when there is something wrong with the brain. It is now clear that loss of the sense of smell is an early marker for Parkinsons disease and other neurodegenerative conditions. Simple smell tests can help clinicians diagnose Parkinsons more accurately, and a series of recent studies further suggest that they could be used to sniff out at-risk patients earlier.. First described in 1871, Parkinsons is chiefly thought of as a movement disorder characterized by slow movements, rigidity, and tremor. It is becoming increasingly clear, however, that Parkinsons also involves various non-motor symptoms, including cognitive impairment, sleep disturbances, and altered smell, taste, and vision. Clinicians recognized that Parkinsons involves loss of the sense of smell in the 1970s, but reliable tests for olfactory dysfunction did not become available until the mid-1980s. The development ...
First-degree relatives that agree to participate (n=3,000) will be asked to complete a 40-item olfactory identification test provided by mail. 300 subjects (225 with decreased odor identification and 75 with normal olfaction) will be invited to undergo DAT imaging at the Institute for Neurodegenerative Disorders in New Haven, CT. There will also be additional clinical follow-up at participants clinical (local) site. The primary outcome measure for the study will be the mean striatal uptake of [123I]B-CIT in first-degree relatives with a loss of odor identification, which will be compared to an established healthy control database (age 40-70; n=50). 300 relatives will be followed longitudinally with clinical evaluations and a second imaging study completed after two years. Comparing the first and second scans in this subset of subjects will allow us to evaluate the rate of progressive loss in dopamine transporter density during this pre-symptomatic period ...
Like the rule of thumb, the smell test is one of those magical tricks that help you make a good decision quickly. Why is this important? Because many people who make a quick decision regret it. Does it pass the smell test? If your heart screams no, believe it and dont get sweet-talked-walk away. In…
The purpose of this agreement is to provide funding for a collaborative effort with the National Center for Health Statistics (NCHS) to pilot test the chemosenses component in persons age 40 and older, and implement in the survey pending a successful pilot. The chemosenses component will consist of 1) household interview questions to define the prevalence of self-reported taste and smell disorders, and to identify risk factors and confounders for the analysis of the taste and smell exam data; 2) smell testing using two modified Pocket Smell Identification Tests, a "scratch and sniff test with 8 odorants; and 3) taste testing performed using small amounts of liquids that can be spit out afterwards. For Taste testing, the respondent will be asked both to identify and to rate the intensity of the stimulus. (ADC12002001-1-0-0) ...
BACKGROUND AND AIM: The sense of taste is a chemical sense which allows everyone to perceive the flavor of what is eaten or drunk. Also, the sense of olfaction is also a chemical sense contributing to the sense of taste to perceive the taste and flavor of food. In the present work, the gustatory and olfactory function in pre- and postmenopausal women and men were studied and compared to each other.METHODS: Fifty postmenopausal women, 50 age-matched men, 50 young women and 50 young men were evaluated in this study and enrolled through simple sampling method. The aim of this study was explained for patients and in case of their consent, they were given the questionnaire. Taste threshold for each of the four main tastes for all of the participants in the study was determined at one step between 8 am to 11 am while they had not consumed any food since one hour before the test. The whole mouth taste method was used in this study. Also, the Davidson and Murphy tests were performed and the quality
Its just an opportunity for new things to come my way. For instance, I can go photograph a wine competition and bring back wonderful images, versus having to be the one where after a flight of wine, Ive just lost it but must trudge on. (This image was taken at the Riverside Wine Competition years ago, thanks to the generosity of Dan Berger and Juliann Savage.). I have something for my eyes (glasses), and even if someone invests something for my nose, Im happy to smell a bit less… versus extending the length of my nose and its capabilities. Enough already!. Its not the changes that happen in our lives that matter. Its how we handle the changes that counts!. For Dans issue, please contact him thorough his Web site for his full story. Its very enlightening, and hes brave enough to put it out there. Im just following his lead. I cant call it an "opinion" because its got a medical name: Hyposmia.. This perhaps might explain to me, however, how Robert Parker can give (for instance) a 2004 ...
Our Beverly Hills Hyposmia Treatments are spearheaded by Dr. Arthur Wu of the Beverly Hills Sinus Center in Cedars-Sinai of Los Angeles, CA.
The results are unique, and they are building blocks for future Head Start nutrition education curriculum development. Food identification skills seem to be a starting point for Head Start preschoolers nutrition and possibly for cognitive development. The Theory of Meaningful Learning suggests that understanding the unique conceptual structure each child has about f/v is essential for developing effective education efforts pertaining to the intake of f/v (Novak and Gowin 1984). A fundamental aspect of these structures, however, is foundational elements such as the proper names of particular fruits and vegetables. These findings illustrate that some (~25 percent) of these preschoolers do not know the names of common f/v, such as "banana." Some preschoolers had no problem identifying the cards. Age, as expected, was associated with higher f/v identification scores. One method of improving a preschoolers identification abilities may be to have the childcare providers name and talk about the foods ...
Evidence from imaging, clinical studies, and pathology suggests that Parkinsons disease is preceded by a prodromal stage that predates clinical diagnosis by several years but there is no established
Can a smell test predict Alzheimers? According to research conducted at Columbia University Medical Center (CUMC), New York State Psychiatric Institute, and NewYork-Presbyterian, it just might. When aging people take an odour identification test, their inability to detect odours may correlate to a cognitive decline and early-stage Alzheimers disease. The two studies that point to […]. ...
BACKGROUND: Alzheimers disease (AD) is the most common cause of dementia and early and accurate diagnosis is important. Olfactory dysfunction is an early sign of AD. The contribution by test of olfactory function has been surveyed in AD vs a line of conditions but remains to be settled in the workup of unselected patients referred with suspected dementia.. METHODS: We performed a two-step investigation: first, a comparative study of healthy controls and probable AD patients to test the applicability of the chosen scents (cuisine study); second, a study of consecutive patients referred to our geriatric outpatient clinic for suspected dementia with the investigating personnel blinded to the results of the Olfactory Test (blinded study).. RESULTS: The sum of scents detected discriminated patients with probable AD from controls in the cuisine study (n = 40; p , 0.001; area under ROC curve 0.94). In the blinded study (n = 50) the diagnosis was probable AD in 48%, minimal cognitive impairment in 24%, ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. ...
Giving residents with mild mental impairment a 10-item smell test may help determine whether they are more likely to develop Alzheimers disease, researchers say.
Environmental and personal air samples were analyzed, employees were interviewed and given a questionnaire, and an odor identification test was conducted at Dana Corporation-Spicer (SIC-3711) Universal Joint Division, Marion, Indiana, in January, 1979 to determine the cause of complaints of mucous membrane irritation. The company employed 990 production and maintenance personnel. The evaluation wa
The following m files are included: discrimination_MLE.m Calculates the discrimination ability of a given population of neurons. This program may take an hour to run categorization_llikhd.m Calculates the identification ability of a given population of neurons. This program may take 4 minutes to run. Both scripts above use the following helper functions: MNRRS.m Gets the response of the population of neurons to a specific frequency. likhood.m The likelihood function (equation 2 in manuscript) get_params.m The parameters used for the simulation (population parameters and testing parameters) Editing this file will suffice to change population or testing parameters smth_gass_distr.m Helper function for get_params to redefine over-representation. categorization_llikhd also includes: binornd_sim.m The Bernoulli random process simulation (Eq 5 in paper) In addition, the following mat files are included: discr_temp.mat output expected at line 93 of discrimination_MLE to plot, use lines 98-103 ...
El Archivo Digital UPM alberga en formato digital la documentacion academica y cientifica (tesis, pfc, articulos, etc..) generada en la Universidad Politecnica de Madrid.Los documentos del Archivo Digital UPM son recuperables desde buscadores: Google, Google Academics, Yahoo, Scirus, etc y desde recolectores OAI: E-ciencia, DRRD, Recolecta (REBIUN-FECYT), Driver, Oaister, etc.
Generally, as people age, their sense of smell also declines, and they may be unaware of the odors they emit. A NCBI study cites that "more than 75% of people over the age of 80 years have evidence of major olfactory impairment, and that olfaction declines considerably after the seventh decade." But there is another element at play when considering how our scents change over time.. In a 2001 study published in The Journal of Investigative Dermatology, researchers discovered that what we categorize as "Old People Smell" is likely due to one chemical compound: 2-noneral.. For their study, the scientists gathered a control group of 22 healthy individuals -- 13 males, and 9 females -- ranging in age from 26 to 75 years old. Each person bathed with odorless soap and shampoo, and was then given a T-shirt to wear (washed and prepared in such a way that no odor was detectable) for three consecutive nights. At the end of this period, swatches of the shirts were cut out examined for various chemical ...
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Alzheimers disease (AD) pathology appears to start in the part of the brain that handles smell before subsequently spreading to additional brain regions a
A simple scratch-and-sniff test may one day be able to help identify some people at greater risk of developing Parkinsons disease up to 10 years before the disease could be diagnosed, according to a new study published in the Sept. 6, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
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Does the CPU fan use a three pin small, four pin small, or four pin large power connection? Can you try another cpu fan to see if it turns? Remove the CPU, taking care not to bend the pins on the bottom. Look on both top and underside for the darkening caused by over heating. Also give it the smell test for burned material. If the CPU is damaged, used CPUs are relatively cheap... $25 to $35 here. Two other suspects: Look at the capacitors on one side of the CPU to see if any one of them are bulging or split and leaking brownish powder. The second largest chip from the CPU is next. Does it have any kind of heat sink without a fan? Look very closely around the edges of that chip. It sometimes works its way out. In which case the motherboard is ruined. The W2646 seems to have a high failure rate. I have three dead ones in the shop. They were dead when they came to me and I have no idea what is wrong with them. Replacement non-eMachine motherboards are under $40, but an eMachine board is needed to ...
I tend to be cautious about past lives, especially famous ones. Its extremely easy, once youve remembered one life that is identifiable, to start wondering if every person you identify with from every era might have been you. Not everything passes the smell test for me. There are a number of past lives Ive ruled…
In the Feb. 17 SN: Magnetic knots, the realities of play, cloned monkeys debut, redating humans African exit, lessons in DNA packing, Martian water loss, a forager smell test, and more. ...
In the Feb. 17 SN: Magnetic knots, the realities of play, cloned monkeys debut, redating humans African exit, lessons in DNA packing, Martian water loss, a forager smell test, and more. ...
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Introduction: Olfactory loss in patients with chronic rhinosinusitis has been measured by different methods. However, the results have been variable, and it is not clear whether endoscopic sinus surgery significantly improves olfactory function. This study was performed to evaluate the influence of endoscopic sinus surgery on olfactory function in patients with chronic rhinosinusitis. Materials and Methods: In this prospective analytic study, 73 patients (mean age, 39.63±12.94 years) with a diagnosis of polyps and sinusitis during 2011 were studied. The olfaction test was performed with three solutions; one with no odor (water) and two with phenylethyl alcohol (50% and 90% dilution, respectively). The patients olfaction state were graded as no olfaction, or low, moderate or good olfaction before and 1 and 3 months after surgery, and was given scores between 0 and 3 and evaluated quantitatively. Results: Right-side olfaction was improved in 68.5% and left side in 67.1% of patients. Mean olfaction
Partly claimed to explain social difficulties observed in people with Asperger syndrome, face identification and visual search strategies become important. Previous research findings are, however, disparate. In order to explore face identification abilities and visual search strategies, with special focus on the importance of the eye area, 24 adults with Asperger syndrome and matched controls viewed puzzle pieced photos of faces, in order to identify them as one of three intact photos of persons. Every second puzzle pieced photo had the eyes distorted. Fixation patterns were measured by an eye tracker. Adults with Asperger syndrome had greater difficulties in identifying faces than controls. However, the entire face identification superiority in controls was found in the condition when the eyes were distorted supporting that adults with Aspergers syndrome do use the eye region to a great extent in face identification. The visual search strategies in controls were more effective and relied on the ...
The olfactory function shows a temporary decline following open rhinoplasty but tends to revert to its preoperative levels 6 months post surgery. This may be a reassuring answer to candidates for this kind of nasal surgery since they are likely to inquire whether the loss or decrease in their sense of smell is reversible, and, if reversible, how long it is before their sense of smell is normal again [24].. One week after open rhinoplasty, anosmia was present in 87.5% of our patients, and the rest exhibited moderate to severe hyposmia. In other words, almost all the patients were anosmic shortly after open rhinoplasty. By postoperative week 6, however, anosmia had downgraded to mainly mild to moderate levels of hyposmia. All our patients had regained their preoperative olfactory function levels by postoperative month 6; most were normosmic and a few were mildly hyposmic.. In a study of 93 patients undergoing various types of nasal surgery, including ethmoidectomy, polypectomy, Caldwell-Luc ...
Here we have demonstrated deficits of flavour identification in two major clinical syndromes of FTLD, bvFTD and svPPA, relative to healthy control subjects. The profile of odour identification performance essentially paralleled flavour identification across subgroups, and there was a significant correlation between flavour and odour identification scores in the patient population. Chemosensory identification deficits here were not simply attributable to general executive or semantic impairment, since the deficits were demonstrated after adjusting for these other potentially relevant cognitive variables. An error analysis showed that identification of general flavour categories was better preserved overall than identification of particular flavours. This pattern would be difficult to explain were impaired flavour identification simply the result of impaired cross-modal labelling. Taken together, the behavioural data suggest that FTLD is often accompanied by a semantic deficit of flavour ...
Results Patients with NPSLE were more depressed and were more frequently impaired in cognitive and olfactory functions than controls or non-NPSLE patients. The NPSLE group remained statistically different from the other 2 groups on a series of neuropsychological measures (the Auditory Verbal Learning Test, Trail Making Test - Part A, Nine-Hole Peg Test, and Brief Smell Identification Test) even after control for elevated anxiety and depressed mood. Non-NPSLE and control groups were not significantly different regarding either psychopathological symptoms or neuropsychological functioning. ...