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Between 0 and 6 h following the administration of a single 200 mg oral dose of ofloxacin to 12 healthy volunteers, the average urine ofloxacin concentration was approximately 220 mcg/mL. Between 12 and 24 hours after administration, the average urine ofloxacin level was approximately 34 mcg/mL.. Following oral administration of recommended therapeutic doses, ofloxacin has been detected in blister fluid, cervix, lung tissue, ovary, prostatic fluid, prostatic tissue, skin, and sputum. The mean concentration of ofloxacin in each of these various body fluids and tissues after one or more doses was 0.8 to 1.5 times the concurrent plasma level. Inadequate data are presently available on the distribution or levels of ofloxacin in the cerebrospinal fluid or brain tissue.. Ofloxacin has a pyridobenzoxazine ring that appears to decrease the extent of parent compound metabolism. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. ...
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Results:. Microbiologically documented overall infection rates for norfloxacin, ofloxacin, and ofloxacin plus rifampin were 47%, 24%, and 9%, respectively (P , 0.001). Corresponding rates were 24%, 13%, and 3%, respectively for staphylococcal bacteremia (P = 0.03) and, 21%, 3%, and 3%, respectively for streptococcal bacteremia (P , 0.01). The pattern of bacteremia suggested that rifampin played a role in suppressing staphylococcal infection. Both ofloxacin alone and ofloxacin plus rifampin had a clinically significant antistreptococcal effect. Aerobic gram-negative rods were cleared from rectal surveillance cultures in all patients after a median of 5.5 days and caused infection in only one patient (0.9%). The reductions in the number of microbiologically documented infections among ofloxacin recipients and ofloxacin plus rifampin recipients were offset by concomitant increases in the number of unexplained fevers (24% of norfloxacin recipients, 53% of ofloxacin recipients, and 49% of ofloxacin ...
The most common side effects of ofloxacin include:. Allergic reactions have been described, such as hives and anaphylaxis (shock).. Other important side effects include symptoms of nervous system stimulation, such as:. Ofloxacin may cause low or high blood sugar levels especially in people with diabetes who are taking insulin or oral hypoglycemic drugs.. Patients taking ofloxacin can develop skin sensitivity (photsensitivity) to direct sunlight and should avoid exposure to sunlight or use sun protection and sunscreens.. Ofloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Some physicians recommend that patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.. Ofloxacin should be used with caution in patients with central nervous system diseases such as seizures because rare seizures have been reported in patients receiving this ...
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Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin ophthalmic (for use in the eyes) is used to treat bacterial infections of the eyes. Ofloxacin ophthalmic is also used to treat an ulcer in the cornea of the eye. Ofloxacin will not treat a viral or fungal...
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Abstract:. Ofloxacin is a fluoroquinolones antibacterial agent with a broad spectrum of activity against gram positive and negative bacteria. It is used in urinary and respiratory tract infections, gonorrhea and skin. Conventional doses vary from 200-600 mg twice or thrice a day, as per severity of infection and its biological half-life is 5-6 hrs. In present study, Ofloxacin microspheres were formulated using polymer and natural gums such as Guar gum and Xanthan gum as rate controlling material by ionic crosslinking technique with an aim to prolong its release. All formulations prepared by using different drug-polymer ratios, were evaluated for relevant parameters. Depending upon the drug-polymer ratio of Guar gum, the percentage yield and encapsulation efficiency of microspheres were found to range between 89.17±6.02 to 94.61±4.95% and 78.40±5.08 to 83.89±4.17% respectively. Also the drug to polymer ratio of Xanthan gum, the percentage yield and encapsulation efficiency were found to range ...
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Ofloxacin is used to treat infection by bacteria. It is a type of quinolone antibiotic. It is used to kill the bacteria that cause infection. It works against a
A Moderate Drug Interaction exists between azithromycin and ofloxacin. View detailed information regarding this drug interaction.
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... is an antibiotic prescribed to treat a wide range of bacterial infections. This eMedTV Web page presents a detailed overview of this medication, with information on the various forms, how it works, side effects, dosing guidelines, and more.
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Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
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Abstract: The present study is undertaken to evaluate the antimicrobial properties of a new Fixed Dose Combination (FDC) of Ofloxacin Ornidazole for infusion against some aerobic bacteria in comparison with Ofloxacin and Ornidazole individually. Antibiotic Susceptibility Test (AST) and Minimum Inhibitory Concentration (MIC) of FDC of Ofloxacin Ornidazole, Ofloxacin and Ornidazole for P. aeruginosa, S. aureus, E. coli, K. pneumoniae, S. epidermis and MRSA were determined by disc method and broth micro dilution method. In Antimicrobial Susceptibility Test, lytic zone of combination was found to be more than Ofloxacin or Ornidazole alone in all microbial strains under study. The MIC value of FDC of Ofloxacin Ornidazole was found to be higher than both Ofloxacin and Ornidazole. The data suggests that fixed dose combination of Ofloxacin and Ornidazole can be a good option for use in mixed microbial infection of aerobic bacteria, anaerobic bacteria and pathogenic protozoans. ...
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