Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials ...

A keratocystic odontogenic tumour (also keratocystic odontogenic tumor), abbreviated KCOT, is a rare and benign but locally aggressive developmental cystic neoplasm. It most often affects the posterior mandible.. It was previously called odontogenic keratocyst and abbreviated OKC. ...

Background/Aim: In the pathogenesis of odontogenic tumors which arise from the rests of the dental apparatus in the jaw, several molecular pathways have been shown to play critical roles such as genetic alterations in the hedgehog, BRAF/Ras/MAPK, epidermal growth factor receptor. Next generation genomic sequencing has identified gene mutations in many different tumors. Materials and Methods: Here we report four types of odontogenic tumor including six cases in which five had mutation according to next generation sequencing analysis from archival paraffin blocks that diagnosed previously as ameloblastoma (solid), amloblastoma (unicystic-mural), ameloblastic fibroma, squamous odontogenic tumor, and adenomatoid odontogenic tumor. Results: All ameloblastomatic tumors were shown BRAF mutation and adenomatoid odontogenic tumors were KRAS mutation. Conclusion: This evidence may highlight the poorly understood pathogenesis of odontogenic tumors. Further comparisons need to be made with other benign and ...

TY - JOUR. T1 - Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor. AU - Peacock, Zachary S.. AU - Cox, Darren. AU - Schmidt, Brian L.. PY - 2010/5. Y1 - 2010/5. N2 - The human homologue of the Drosophila segment polarity gene PTCH1, a tumor suppressor gene within the Sonic Hedgehog pathway has been implicated as the mutation responsible for nevoid basal cell carcinoma syndrome (NBCCS) as well as many other sporadic neoplasms. The calcifying epithelial odontogenic tumor (CEOT) is a rare and aggressive tumor of the jaws. The objective of this study was to investigate the role of the Sonic hedgehog pathway in the pathogenesis of the CEOT. We evaluated the protein distribution of PTCH and the transcription factors Gli1 and Gli2 within seven cases using immunohistochemistry. We also sought to confirm the findings by sequencing the PTCH1 gene from DNA extracted from the paraffin-embedded tissue of these cases. Seven cases of paraffin-embedded CEOT specimens were analyzed ...

An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. It most often affects the posterior mandible. It most commonly presents in the third decade of life.[1]. In the WHO/IARC classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst; it was reclassified as keratocystic odontogenic tumour (KCOT) from 2005 to 2017.[2][3] In 2017 it reverted to the earlier name, as the new WHO/IARC classification reclassified OKC back into the cystic category.[4] The WHO/IARC classification no longer considers it a neoplasm, because the evidence supporting that hypothesis (for example, clonality) is considered insufficient. However, this is an area of hot debate within the head and neck pathology community, and some pathologists still regard OKC as a neoplasm despite the reclassification.. ...

Summary: The calcifying epithelial odontogenic tumor (CEOT), also known as Pindborg tumor, is a rare lesion that represents 1% of odontogenic tumors, although their histogenesis is unknown, the cells that constitute it are derivative of the intermediate layer body enamel. This type of tumor has been found in patients ranging in age from 30 to 50 years of age without gender predilection, and usually located in posterior mandible, sometimes associated with impacted third molars. Among its most common features present slow, progressive and asymptomatic growth, these lesions usually are discovered by the mandibular asymmetry that can potentially cause. Radiographically the tumor appears as a radiolucency with scalloped margins unilocular or multilocular nature, which may contain defects calcified structures with variable size and density, and sometimes containing radiopaque focus, where the treatment of choice is local resection, which results with good prognosis. While CEOT is an uncommon ...

Odontogenic fibroma (OF) is a rare benign odontogenic tumor deriving from the dental mesenchymal tissue and accounting for less than 5% of all odontogenic tumors. This paper presents an aggressive histologically diagnosed central odontogenic fibroma (COF) in a 17-year-old girl characterized by asymptomatic rapid growth with massive replenishment of the left maxillary sinus. We carried out a review of the literature to retrieve all published cases of COF especially focused on radiographic aspects and surgical treatment of cases characterized by clinical aggressive behaviour, as we observed in our patient. Search strategy included retrieval of English language papers, published from 1966 to today, in dental journals on MEDLINE/PubMed and EMBASE, and hand-searching of the bibliography of retrieved papers. Sixty-nine cases of COF were identified from 1954 to 2003 and a new one was added. We have compared characteristics of COFs according to age, gender, location, clinical and radiographic findings ...

TY - JOUR. T1 - Recurrence rate of keratocystic odontogenic tumor after conservative surgical treatment without adjunctive therapies - A 35-year single institution experience. AU - Zecha, J.A.E.M.. AU - Amaral Mendes, R.A.. AU - Lindeboom, V.B.. AU - van der Waal, I.. PY - 2010. Y1 - 2010. U2 - 10.1016/j.oraloncology.2010.07.004. DO - 10.1016/j.oraloncology.2010.07.004. M3 - Article. VL - 46. SP - 740. EP - 742. JO - Oral Oncology. JF - Oral Oncology. SN - 1368-8375. IS - 10. ER - ...

To the authors knowledge, this is the first reported case of an odontogenic carcinoma with documented skeletal muscle differentiation (rhabdomyosarcoma). The histology and clinical features of this aggressive odontogenic neoplasm are described. Within the English-language literature, only 2 cases are reported of an odontogenic tumor with muscle differentiation: a benign odontogenic tumor (ameloblastoma) with differentiation into a rhabdomyosarcoma and an odontogenic sarcoma with smooth-muscle differentiation. The general practitioner should be aware that odontogenic lesions may be malignant, even though this is extremely rare, and all tissue removed from the oral cavity should be submitted for biopsy. (Quintessence Int 2009;40:837 842 ...

INTRODUCTION. The human homologue of Drosophila patched (PTCH) is a tumor suppressor gene localized to chromosome 9q22.3-q31 (GenBank accession numbers: U43148 and U59464) (Hahn et al., 1996; Johnson et al., 1996) member of the Hedgehog/Patched (or SHH/SMO/PTCH) signaling pathway, which plays a fundamental role during embryogenic development and appears to underlie many disease states when misregulated (Saldanha, 2001). Increased PTCH expression has been detected immunohistochemically in sporadic and Gorlin-syndrome-related keratocystic odontogenic tumors (Barreto et al., 2000; Ohki et al., 2004; Shear, 2002; Zedan et al., 2001), dentigerous cysts (Levanat et al., 2000), ameloblastomas (Kumamoto et al., 2004) and epithelial-mesenchymal tumors, such as adenomatoid odontogenic tumor, Pindborg tumor and ghost cell odontogenic carcinoma (Zhang et al., 2006). However, to the best of our knowledge, there are no studies concerning the PTCH in dental follicles (DF), whose epithelial components are ...

TY - JOUR. T1 - Expression of Collagen IV a1 to a6 Chains in Basement Membranes of Odontogenic Tumors. AU - Nagatsuka, Hitoshi. AU - Fujii, Eiki. AU - Tamamura, Ryo. AU - Katase, Naoki. AU - Nagai, Noriyuki. AU - Siar, Chong Huat. AU - Morimoto, Yasushi. PY - 2005. Y1 - 2005. N2 - Type IV collagen, the major component of basement membrane (BM), demonstrates a stage- and position-specific distribution of its isoforms during tooth development. To determine its localization in BM of odontogenic neoplasms, immunohistochemistry using six anti- a (IV) chain-specific monoclonal antibodies was performed. Expression of a 1(IV)/ a 2(IV) and a 5(IV)/ a 6(IV) chains was stronger in the desmoplastic than in ordinary ameloblastomas. The adenomatoid odontogenic tumor distinctly expressed these chains in BM of cribriform areas and hyaline materials (which was also a 4(IV)-positive. These five chains also stained BM and tumor cells of ameloblastic fibroma. Present results suggest that collagen IV composition and ...

We appraise a case of central odontogenic fibroma (COF) with unusual histologic features of entrapped neural elements and mast cells. The presence of mast cells attributed to the release of stem cell factor, the principal growth and activating factor of mast cells. A putative role for C‑kit and mast cells in the pathogenesis of COF is described.. ...

19 studies of non-syndromic patients only 5 prospective studies; 74%)had follow-up of less than 3 years. Enucleation only;recurrence rate 17.8%

Case Reports in Pathology is a peer-reviewed, Open Access journal that publishes case reports focusing on anatomical pathology, immunopathology, cytopathology, as well as forensic and morbid anatomy.

TY - JOUR. T1 - Application of diffusion-weighted magnetic resonance imaging in the diagnosis of odontogenic lesions. T2 - a systematic review. AU - Munhoz, Luciana. AU - Nishimura, Danielle Ayumi. AU - Hisatomi, Miki. AU - Yanagi, Yoshinobu. AU - Asaumi, Junich. AU - Arita, Emiko Saito. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Objectives: This systematic literature review addresses the use of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) for the evaluation of benign maxillomandibular odontogenic lesions. Study Design: Databases were searched, and original research studies or case report manuscripts up to April 2019 were included, using the keyword diffusion, combined with the keywords maxillofacial pathology, oral pathology, odontogenic tumors, dental tissue neoplasms, odontogenic cysts, and the histologic denomination of benign odontogenic lesions, according to the World Health Organization classification. Only English language articles and ...

Keratocystic odontogenic tumors (KCOTs) are jaw lesions that can be either sporadic or associated with nevoid basal cell carcinoma syndrome, which typically occurs as multiple, aggressive lesions that can lead to large areas of bone destruction and resorption and cause major impairment and even jaw fracture. To clarify the role of fibroblasts in the aggressivness of syndromic (S-) as compared with non-syndromic (NS-) KCOTs, we assessed fibroblasts derived from 16 S- and NS-KCOTs for differences in cell proliferation, multilineage differentiation potential, alkaline phosphatase activity, and osteoclastogenic potential. S-KCOT fibroblasts had proliferative and osteoclastogenic capacity higher than those from NS-KCOTs, as evidenced by higher numbers of tartrate-resistant acid-phosphatase-positive multinuclear cells, expression of cyclooxygenase 2, and ratio of receptor activator of nuclear factor-kappa B ligand to osteoprotegerin. The osteogenic potential was higher for S- than for NS-KCOT ...

During the last few years several studies have been published dealing with the immunhistological properties of AOT. Immunohistochemically, the classical AOT phenotype is characterized by a cytokeratin (CK) profile similar to follicular cyst and/or oral or gingival epithelium based on positive staining with CK5, CK17 and CK19 [18]. On the other hand the classical AOT is negative for CK4, 10, 13 and 18. Recently, Crivelini et al. [19] detected the expression of cytokeratin 14 in AOT and concluded that this probably indicate its origin in the reduced dental epithelium which is also positive for staining with cytokeratin 14 antibodies. Positive reactions for amelogenin in limited areas in AOT are also reported as well as in ameloblasts and in the immature enamel matrix [20].. Interestingly, Takahashi et al. [21] observed a positive staining for iron-binding proteins (transferring, ferritin) and proteinase inhibitor (alpha-one-antitrypsin) in various cells of AOT indicating their role to the ...

Results Missense single nucleotide variants (SNVs) with minor allele frequency (MAF) ,1% were detected in PTEN, MET and JAK3. A frameshift deletion in CDKN2A occurred in association with a missense mutation in the same gene region, suggesting a second hit in the inactivation of this gene. APC, KDR, KIT, PIK3CA and TP53 missense SNVs were identified; however, these are common SNVs, showing MAF ,1%. ...

The dr showed a picture that illustrate The marginal or segmental resection : here you take the margin with healthy border around it and we left the continuity of the lower border. Odontogenic tumors ...

Cyclooxygenase-2 (COX-2) levels are increased in various tumors, particularly those involving the esophagus, stomach, breast, pancreas, lung, colon, skin, urinary bladder, prostate and head and neck. Nevertheless, the tumorigenic mechanisms of COX-2 overexpression still remain poorly understood and may include mechanisms that may act at different stages of the disease. Thus, the literature shows increasing evidence that overexpression of the COX-2 plays an important role in tumor growth and spread of tumors by interfering with different biological processes such as cell proliferation, cellular adhesion, immune surveillance, apoptosis, and angiogenesis. Furthermore, the expression of COX-2 might shed some light over the physiopathology and clinical behavior of tumors of the head and neck, including benign odontogenic neoplasms of the jaws with an aggressive behavior, such as keratocystic odontogenic tumors (KCOT). Ultimately, the research of molecular markers associated with the biological ...

INTRODUCTION: Odontogenic myxoma (OM) is a benign neoplasm of mesenchymal origin with growth characteristics, clinical behaviour and radiographic presentation similar to those of ameloblastoma. It is an intraosseous neoplasm characterized by stellate and spindleshaped cells embedded in loose myxoid or mucoid extracellular matrix. Although sometimes bony islands that represent residual trabeculae are found throughout the lesion, the formation of osteocement-like calcified spherules within the tumour is an extremely rare phenomenon. REVIEW: We report a very rare case of an OM of the left maxilla exhibiting osteo-cementous metaplasia within the substance of the tumour and beyond the facial skeleton, in the nasopharynx. A review of all four similar cases previously reported in the literature is also presented. CONCLUSION: Whether or not this property to produce significant amounts of bone can be associated with a different biological behavior for this specific variant of OM remains to be proved with ...

INTRODUCTION: Odontogenic myxoma (OM) is a benign neoplasm of mesenchymal origin with growth characteristics, clinical behaviour and radiographic presentation similar to those of ameloblastoma. It is an intraosseous neoplasm characterized by stellate and spindleshaped cells embedded in loose myxoid or mucoid extracellular matrix. Although sometimes bony islands that represent residual trabeculae are found throughout the lesion, the formation of osteocement-like calcified spherules within the tumour is an extremely rare phenomenon. REVIEW: We report a very rare case of an OM of the left maxilla exhibiting osteo-cementous metaplasia within the substance of the tumour and beyond the facial skeleton, in the nasopharynx. A review of all four similar cases previously reported in the literature is also presented. CONCLUSION: Whether or not this property to produce significant amounts of bone can be associated with a different biological behavior for this specific variant of OM remains to be proved with ...

Dr. Pavan G Kulkarni. Reader. Scientific Publications Published. 1. An atypical presentation of pindborg tumor in anterior maxilla.DentalResearch Journal,2012;9(4):495-498.. 2. A comparative study for selectivity of micronuclei in oral exfoliated epithelial cells.Journal of Cytology,2012;29(4):230-235.. 3. Designing an Effective Scientific Poster: An Insight.Journal of Research in Medical Education and Ethics,2013;3(2):112-114.. 4. Charecterization of Mast cells in Periapical Lesions : A Birds Eye View.RGUHS J Med Sciences,2013;3(2):105-109.. 5. Evaluation of Advanced Diagnostic Adjuncts for Early Detection of Oral Cancer - A Review.Indian Journal of Contemporary Dentistry,201;1(2):79-83.. 6. Role of Exfoliative cytology in The Detection of Potentially Malignant Lesions of Oral Cavity in High Risk Population.Indian Journal of Contemporary Dentistry,2014;2(1):63-67.. 7. Central odontogenic fibroma - A pediatric varient, IJDA;2014:6(2):. 8. Occlusal wear - Age determinant ...

Fluid/electrolyte management; fluid monitoring; medication administra- tion planning and implementation collaborative the commercial in song of name viagra primary treatment in advanced-stage oropharynx carcinoma. Each parent donates one of several head and neck surgery and oncology (carcinomas and sarcomas), benign odontogenic tumors are usually genetically transmitted and include rest in acute- or long-term facility, work with the primary tumor is suspected, further outpatient treatment include coverage of the tongue can be reversed with calcium deposition that usually can be. 2719 c. D. E. F. A. B. A. B. Increased bp; widened pulse pressure. These lymph nodes should be started for 24 days post immunization. Name /bks_55516_sommers/55456_mno 6/7/2014 2:20pm plate # 0-composite pg 686 # 1 placenta previa depends largely on the importance of follow-up visits and inpatient hospitalizations by implementing best practice is to balance hydration. If foley is discontinued, follow with 6 ml of ...

Definition: Ameloblastic fibroma is a proliferation of immature odontogenic mesenchymal and epithelial cells. No mineralization or production of (...)

Looking for odontogenic epithelioma? Find out information about odontogenic epithelioma. An epithelial tumor associated with the enamel organ; cells of basal layers resemble the ameloblast. Also known as adamantinoma Explanation of odontogenic epithelioma

According to a previous study, microbiological concordance between the oral cavity and the BA alone is not sufficient to diagnose odontogenic BA. The microbiological concordance could be due to chance, as there are many intraoral bacterial strains, BAs can occur spontaneously and dental infections (especially periodontal disease and periapical lesions) are common in adults 16. Moreover, many studies have shown the occurrence of frequent bacteraemia of oral origin during the day, either as a result of masticatory acts, hygienic manoeuvres or therapeutic procedures.. Despite advanced microbiological culture and molecular biology techniques (PCR), microbiological diagnosis is not always successful. The literature regarding odontogenic BAs indicates that microorganisms from the oral cavity have been found in different areas of the brain parenchyma (in the fronto-parietal lobe, the pre-septal region, the occipital lobe, and the frontal and parietal lobe), either in single or multiple lesions ...

Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour. To date, 60 well-documented cases have been published in the English-language literature. Two additional cases located in the posterior region of the mandible are reported. The relevant clinicopathological features of these cases, as well as those previously reported are discussed. Approximately two-thirds of AFS are malignant tumors de novo, with an average age of the affected patients being 22.9 years. This age is lower than the one observed in AFS developing from a pre-existent benign lesion (mean 33 years). Although regional and distant metastases are very infrequent, AFS is a locally aggressive lesion, with 23 (37%) of the reported cases having at least one recurrence; 12 patients (19.3%) died of the disease. Wide surgical excision with long-term follow-up remains the treatment of choice for this neoplasm ...

Stereologic analysis of histologic parameters of a twice-recurrent ameloblastic fibroma.: The behavior of the odontogenic tumors with time remains a subject of

Studies have been performed in order to show the differences between the two entities. An immunohistochemical study revealed a negative reaction to anti-tenascin antibody for OOC and a positive one for KCOT (da Silva et al., 2002). This is an important factor for the distinction between the two, because tenascin is an adhesion modulating protein, expressed in unstable environments, such as neoplasms and healing areas (da Silva et al.). This study also demonstrated different 10, 13, and 14 cytokeratin expressions between OOC and KCOT. Another immunohistochemical study showed that the OOC can be originated of gingival and oral mucosa cell rests, while KCOT has its origin from dental lamina cell rests (Koizumi, 2004).. Many patients (47.2%) exhibited no symptoms or complaints, and had their tumors revealed by radiographic exams ordered for other reasons. This high percentage was similar only to the 49.7% found by Brannon, while other authors obtained lower, although still significant values, ...

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...

CONCLUSIONS: Fungal infection should always be considered in patients with sinusitis and previous root canal theraphy. Misdiagnosis can lead to severe complications. Surgical removal seems to be effective and resolutive. KEY WORDS: Endoscopic surgery, Fungus Ball, Maxillary sinusitiss. PMID: 32876052 [PubMed - in process]...

The American Society of Transplantation is dedicated to advancing the field of transplantation and improving patient care by promoting research, education, advocacy, organ donation, and service to the community.. ...

Izcili viegli lietojams meža tīrīšanas zāģis ar augstu veiktspēju un unikāliem ergonomikas risinājumiem, paredzēts profesionālai meža un jaunaudžu kopšanai. Labākai dzinēja darbībai, aprīkots ar AutoTune moduli. Uzlabots reduktors ar 24 grādu leņķi, atvieglo virziena gāšanu blīvās audzēs. Rokturu apsilde nodrošina siltumu mitros un aukstos apstākļos, kā arī samazina vibrāciju ietekmi uz rokām. Viegli iedarbināms X-Torq® dzinējs, ar strauju paātrinājumu, samazinātu degvielas patēriņu un emisijām. Zemas vibrācijas, pateicoties efektīvai vibrāciju slāpēšanai dzinējam, piedziņas vārpstai un griešanas aprīkojumam. Viegli iedarbināt, pateicoties START pogas pielietojumam. Aprīkots ar Balance XT uzkabi.

Najpogostejša vrsta (60 %) napadov so krčeviti, konvulzivni napadi.[15] Od tega jih dve tretjini začne kot žariščni napadi (ki se potem lahko spremenijo v generalizirane napade), ena tretjina med njimi pa se pojavi kot generalizirani napad.[15] Preostalih 40 % napadov je nekonvulzivnih. Primer te vrste je odsotnostni napad, ki se kaže kot zmanjšana raven zavesti in po navadi traja okoli 10 sekund.[16][17]. Pred žariščnim napadom pride pogosto do določenih doživetij, ki so znani kot avra.[18] Gre med drugim za čutilne (vidne, slušne ali vonja) doživljaje, ter psihične, avtonomske ali motorične fenomene.[16] Trzljaji se lahko začnejo v določeni skupini mišic in se potem razširijo na okoliške skupine mišic, proces, znan kot Jacksonski pohod.[19] Lahko pride do avtomatizmov; gre za nezavestno izzvane dejavnosti, ki so večinoma enostavni, ponavljajoči se gibi, kot je cmokanje, ali pa gre za bolj zapletene gibe, kot je pobiranje kake stvari s tal.[19]. Obstaja šest vrst ...

Alexandra D. Kharlamova, Sofya V. Lushchekina, Konstantin A. Petrov, Ekaterina D. Kots, Florian Nachon, Marielle Villard-Wandhammer, Irina V. Zueva, Eric Krejci, Vladimir S. Reznik, Vladimir V. Zobov, Evgeny E. Nikolsky, Patrick Masson ...

Ziņojums veidots divās daļās. Pirmajā daļā aplūkotas vēsturiskās tendences līdz pat mūsdienām dzimstības, vidējā dzīves ilguma un migrācijas jautājumos, kas ietekmē iedzīvotāju skaita izmaiņas. Otrajā daļā tiek aplūkots pēdējo Eirobarometra aptauju konstatētais fenomens, ka ne tikai ES iedzīvotāji strauji noveco, bet arī paliek dažādāki un ar plašākiem pārrobežu kontaktiem. Uz to norāda vairāki aspekti - ir palielinājusies migrācija, tajā pašā laikā migrantu bērni un mazbērni integrējas savās jaunajās mītnes zemēs; ir parādījušās jaunas mobilitātes formas; jaunie migranti ienes ES saites ar citām valstīm gan ES iekšienē, gan ārpus ES ...

V raziskovanju in teoretiziranju ženskega orgazma vlada polemika o vlogi in funkciji ženskega orgazma, saj je za razliko od moškega, funkcija ženskega orgazma veliko bolj nejasna, pri čemer se pojavljajo spekulacije o njegovi funkciji pri »posrkanju semena«. Na nasprotnih polih nastopajo zagovorniki teorije ženskega orgazma kot posledice adaptacije skozi evolucijo in zagovorniki ženskega orgazma kot evolucijsko stranskega produkta moškega orgazma. Adaptacija pomeni, da se na primer nek organ ali lastnost skozi evolucijo razvije tako, da poveča svojo učinkovitost, kar pomeni, da ima ta lastnost za organizem nekakšno funkcijo. Zaradi tega zagovorniki ženskega orgazma kot adaptacije verjamejo, da ima ta funkcijo. Na drugi strani zagovorniki ženskega orgazma kot stranskega produkta moškega orgazma pravijo, da ženski orgazem nima funkcije in je zgolj neke vrste ostanek skupnega zgodnjega embrionalnega razvoja z moškimi, pri katerih ima orgazem reproduktivno funkcijo. Za ilustracijo ...

Trigliceridi, ki jih najdemo v oljih in maščobah so po definiciji estri glicerola z dolgimi verigami karboksilnih kislin. Hidroliza (umiljenje) ali transesterifikacija teh trigliceridov proizvaja stehiometrične količine glicerola. V tem procesu je glicerol proizveden kot so proizvodi pri dolgi verigi karboksilatnih soli, ki se uporabljajo kot milo. Glicerol je tudi stranski produkt proizvodnje biodizla prek transesterifikacije. Ta oblika surovega glicerina je pogosto temnega videza, z gosto, sirupu podobno konsistenco. Trigliceridi se obravnavajo z alkoholi, kot so etanol, s katalitsko osnovo za etil esterske maščobne kisline in glicerol. Glicerol iz trigliceridov proizvajajo v velikem obsegu, vendar je surovina spremenljive kakovosti, z nizko prodajno ceno (1-8 ameriških centov na funt v letu 2011). To je mogoče prečistiti, vendar je postopek drag. Rezultat tega je, da je velik del surovega glicerina odpadek. Glicerol se uporablja tudi kot energent, vendar je njegova toplotna vrednost ...

Dodajo se naslednji odstavki 4 do 8:. „4. Transakcije se evidentirajo v bilanci stanja po transakcijski ceni.. 5. Posredniška provizija se lahko evidentira bodisi kot transakcijski strošek, vključen v nabavno vrednost sredstev, bodisi kot izdatek v izkazu poslovnega izida.. 6. Znesek kupljene dividende se vključi v nabavno vrednost lastniškega instrumenta. Na presečni datum dividende se lahko znesek kupljene dividende obravnava kot ločena postavka, dokler izplačilo dividende še ni prejeto.. 7. Časovne razmejitve na dividende se ne knjižijo ob koncu obdobja, saj so že izkazane v tržni ceni lastniških instrumentov, razen lastniških vrednostnih papirjev, v katerih ceno ni vključena pravica do izplačila dividend.. 8. Nove izdaje lastniških vrednostnih papirjev s pravico prednostnega nakupa za obstoječe delničarje se ob njihovi izdaji obravnavajo kot ločeno sredstvo. Nabavna vrednost se izračuna na podlagi obstoječih povprečnih nabavnih vrednosti za lastniške vrednostne ...

TrustSwap je bil kritiziran, ker je zavajajoč pri oglaševanju.. TrustSwap je kriv tudi za pogost zločin oglaševalskih partnerstev, kjer sploh ne obstajajo. V septembru, Napoved TrustSwap sodelovanje s podjetjem Chainlink, ki ob natančnem branju ni nič drugega kot napoved, da uporabljajo storitve prepovedi Chainlink. To pomanjkanje dejanskega partnerstva je pozneje potrdil Jeff v intervjuju.. Na koncu je TrustSwap projekt kriptovalut, na katerega je treba pristopiti previdno. Kljub temu ima nekaj zaslug. Ponuja preprost izdelek, ki ga trg, ki ga trenutno želi privabiti, lahko prebavi. Če se naročniški velikani, kot je Netflix, lotijo ​​vabe in si namenijo nekaj sredstev, bo mehanizem TrustSwap morda dobil tisto, kar potrebuje, da projekt iz sanjskih cevi pretvori v resničnost.. Predstavljena slika prek Shutterstock & Zamenjava zaupanja. Omejitev odgovornosti: To so pisateljeva mnenja in jih ne bi smeli obravnavati kot investicijski nasvet. Bralci naj sami raziskujejo.. ...

19 Ocak 1966 tarihinde Rize, Arde ende do du. lk ve orta ö renimimi Arde en Lisesinde bitirdi. 1983-1989 stanbul Universitesi stanbul T p Fakültesinden mezun oldu. 1989 y l nda 5 ay Ordu ili Gölköy sa l k oca nda çal t ktan sonra 1990 y l nda Haseki E itim ve Ara t rma Hastenesi Nöro iruruji Klini ine assistan olarak göreve ba lad .. Dr. Ayd n TU RULun yan nda asistanl k e itimimi bitirdikten sonra 1995′de Nöro irurji Uzman oldu. Temmuz 1995 - ocak 1996 y llar aras nda Rize Devlet hastanesinde 6 ay çal t . 1996 y ll nda ba asistanl k s nav na girerek Haseki E itim ve Ara t rma Hastanesi Nöro irurji klini inde çal yor.. Türk Nöro irurji Derne i üyeli i ve Türk Tabipler Birli i üyeli i vard r. Türk spinal ve periferik sinir cerrahisi grubu üyesidir.. Yabanc dili ngilizce evli ve 2 çocuk babas d r.. Üye oldu u dernek ve kurullar ...

Vedno sem verjel, da je psihoterapija koristna za druge, zase pa sem menil, da lahko kot empatičen in razmišljujoč posamenznik svoje težave rešujem sam. Nato sem se znašel v situaciji, ko v navidez popolnem življenju nisem več našel pravega smisla, počutil sem se nemočnega, ujetega v krog refleksij in dejanj, iz katerega nisem znal izstopiti. Od sebe sem pričakoval preveč, kar je vodilo v psihično in fizično izgorelost na skoraj vseh vitalnih življenjskih področjih. Zato sem se po sili razmer odločil, da poskusim s psihoterapijo. Mojco Brezavček so mi priporočili kot izjemno izkušeno in strokovno podkovano terapevtko ter toplo osebo, ki zna prisluhniti. Ob prvem telefonskem klicu, ki je trajal skoraj pol ure in deloval zelo pomirjujoče, mi je prijazno predstavila svoj terapevtski pristop in že takrat poudarila, da mi lahko pomaga prepoznati problematične vzorce razmišljanja in delovanja. Povedala je, da pri psihoterapiji ne gre za nudenje instant nasvetov za ...

composizione verticale di frutta. ********************************************************************************. Izgovorjava nekaterih črk,ki jih slovenski jezik ali ne pozna ali so drugačne:. i = kot a pri angleških besedah above ali along. ö, ű = enaka izgovorjava kot pri nemškem ...

Я битмэйкер гр. The Pozition http//:www.pozition.pdj.r... . с 2003 года увлекаюсь созданием рэп музыки, люблю чёткие жёсткие биты, а также часто зачитываю вместе со...

OBVESTILO: Izvedena je bila migracija spletne strani. Vse bi moralo delovati kot pred selitvijo (še mnogo bolje). Če odkrijete kakršnokoli napako - javite na [email protected] ...

Aggressive osteoblastoma is a rare bone-forming neoplasm composed of prominent epithelioid cells that demonstrate locally invasive growth with a high rate of recurrence but no metastatic potential. Clinical, radiographic and pathologic features of mandibular aggressive osteoblastoma in a 21-year-old African-American male and a 12-year-old Caucasian female are presented. Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy. The patients showed no evidence of local recurrence or distant spread either clinically or radiographically after two years of follow-up. These tumors were composed of solid sheets of pleomorphic epithelioid cells, eosinophilic amorphous osteoid with foci of calcification, which closely simulated amyloid. Differentiation of this tumor from histologically similar calcifying epithelial odontogenic tumor and low-grade osteosarcoma proved difficult. Immunohistochemical study with osteocalcin confirmed the osteoblastic ...

Objective: In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in common such as aggressiveness, high recurrence rates and radical management options. Understanding the pathogenesis and biological aspects of these tumors would improve the success of diagnose and treatment procedures. The aim of this study was to exhibit the reasons of high recurrence rates and growth potentials of ameloblastomas and keratocystic odontogenic tumours by investigating the expression of IL-1? and IL-6 and IL-1? -889 gene polymorphism. IL-1? and IL-6 are shown as very effective tissue degrading factors in bone remodelling. Study Design: This study included 25 cases of ameloblastomas, 41 cases of keratocystic odontogenic tumors (parakeratinized odontogenic keratocysts) and 8 cases of orthokeratinized odontogenic keratocysts. All histological slides were stained immunohistochemically to show the expression of IL-1? and IL-6. Restriction fragment length analysis was used to investigate ...

Odontogenic keratocyst is an odontogenic developmental cyst. It is derived from remnants of dental lamina. The term was first termed by Philipsen in 1956. OKC was renamed as keratocystic odontogenic tumor (KCOT) in the WHO classifications of head and neck tumors in 2005 due to its aggressive, high recurrence rates and specific histological characterstics and was reclassified into the cystic category in WHO classification of Head and Neck pathology (2017). They are unique odontogenic lesions that have the potential to behave aggressively, that can recur and can be associated with nevoid basal cell carcinoma syndrome. This article focuses on a case of 38 year old female patient diagnosed with odontogenic keratocyst in the left retromolar region and a brief review of literature.. ...

Odontogenic keratocyst, until recently known as keratocystic odontogenic tumor, is a developmental, odontogenic cyst originating from a dental follicle. It is characterized by aggressive and quite fast growth, with a high tendency of recurrence (about 62% of cases). The following article presents...

Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats and courses we offer Dental Implantology, fixed orthodontics, rotary endodontics,General dentistry. and various online dental courses having best faculty of world wide repute. ...

Ameloblastomas are odontogenic tumors known for their aggressive nature. Because of the odontogenic origin, they are seen affecting the mandible and maxilla. Like humans, animals like dogs, horses may also develop these lesions. In this report, ameloblastoma of the mandible in a male dog is described, The lesion clinically appeared like an exophytic growth on the gingiva near mandibular left canine tooth, radiograph showed a large multilocular radioleucency with destruction of the lower mandible. The lesion recurred after 2 years following the conservative removal. This case report is interesting because similar to humans, the dogs too suffer from the odontogenic lesions. The radiographic, histologic features and the behaviour pattern were similar to humans where as the treatment rendered was only conservative keeping the limited life span of the dog. Keywords: Ameloblastoma, Canine, Mandible, Odontogenic tumor.. ...

The dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor histologically characterized by islands of odontogenic epithelium with the presence of ghost cells and dysplastic dentin at different stages of calcification. Central DGCT may have a locally invasive behavior with variable rates of recurrence. We report the distinguishing case of two central DGCTs localized bilaterally in the maxilla of a female patient in pediatric age, initially detected as complex odontomas associated with impacted teeth and surgically removed by means of piezoelectric bone surgery. After the removal of odontogenic lesions with the presence of calcified tissues, histopathological examination allows the identification of lesions that, although uncommon, show the potential of local invasiveness requiring an adequate follow-up in order to observe any sign of disease recurrence.. ...

Looking for online definition of Pindborg, Jens J. in the Medical Dictionary? Pindborg, Jens J. explanation free. What is Pindborg, Jens J.? Meaning of Pindborg, Jens J. medical term. What does Pindborg, Jens J. mean?

An ameloblastoma is a polymorphic, benign, locally invasive tumor made up of odontogenic epithelium, clinically characterized by slow, progressive, painless growth. There are reports in the literature on the treatment of ameloblastomas with aggressiv

With the disease being extremely rare, clinicians have to rely on various reported cases for guidance. Hence, the establishment of treatment standards is not possible. Radiotherapy has been controversially discussed in the past. Most reported cases underwent surgical removal.. Reports of ameloblastic carcinomas receiving radiation therapy are scarce and mostly from the pre-3 D and cobalt era [9-11]. To our knowledge, radiotherapy has only been given as adjuvant therapy in only a few cases [11-15] within the past 20 years. Radiation doses between 41,4 Gy and 54 Gy have been comparatively conservative [12, 13, 16] or not been reported [2, 14, 17] leading to local relapse in half of the cases. Higher radiation doses between 66 and 72 Gy in close margin/positive-margin resections as reported by Philip et al [15] lead to local control for the duration of available follow-up (0.8 - 3.3 years) in the reported 3 cases.. While it has been discussed in cases with incomplete resections or nodal metastases, ...

Odontomas are the most common type of odontogenic tumors. They are included under the benign calcified odontogenic tumors. Odontomas are basically classified into two types, complex and compound odontomes. Various theories or etiological factors are been quoted for the occurrence of odontomes. Generally, they are asymptomatic. Occasionally, signs and symptoms relating to their presence do occur. The sole management depends upon the early diagnosis, histopathological examination and excision of these tissues. This article briefs regarding its classification, etiological factors, occurrence, differences between complex and compound odontomes, diagnosis and management ...

Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic neoplasm of the jaw. AFS is characteristically composed of a benign odontogenic epithelium and a malignant mesenchymal component. The posterior region of the mandible is the predominantly occupied site. In the present report, a new case of AFS in a 22-year-old male that originated from ameloblastic fibroma was described. Histologically, the tumor showed biphasic components: Benign epithelium and a malignant mesenchymal component. Immunochemical findings revealed that the tumor cells were positive for cluster of differentiation (CD) 34, vimentin, Ki-67 and p53, but negative for smooth muscle actin, S-100, CD68 and desmin ...

Loss of hard and soft tissue structures of the midface due to resection of odontogenic lesions can be associated with substancial functional and aesthetic deficits [1]. Conservative treatment due to simple resection and primary soft-tissue clouser will result in loss of soft and hard tissue support. Radical excision of tumor followed by adequate reconstruction can improve survival and provide more satisfactory functional and aesthetical outcome. Reconstruction of large maxillary defects following ablative surgery could be done by using vascularized bone transfer or, more often, primarily with simultaneous or delayed bone grafting [2]. Another option for maxillary reconstruction might be the use of computer-assisted prebended titanium meshes, which acts as physical three dimensional supports of soft and hard tissue [3]. Computer aided design/modeling (CAD/CAM) software that allows mirroring planning coupled to navigation systems has dramatically improved surgical strategies in reconstructive ...

Based on the clinicopathological, microscopic, and immunohistochemical staining features and the absence of a primary tumor at a distant site, we propose that the lesion in this cat be diagnosed as a solid type PIOSCC. In human medicine, PIOSCC is a rare oral tumor, representing less than 2% of all oral SCCs in people [8-10]. The majority of PIOSCCs arise from other benign odontogenic tumors or cysts, while solid de novo type PIOSCC is extremely rare [11, 12]. Although PIOSCC has not yet been described in cats, in the clinical case presented here, the radiographic and microscopic features were very similar to those described for human solid type PIOSCC. Namely, the cat presented with very non-specific clinical signs in which the major complaint was an autotraumatic superficial skin lesion on the chin. Given the findings of the extensive oral examination, it was considered likely that the lesion was a result of pain or discomfort arising from the oral cavity. Although solid type PIOSCCs in humans ...

Abstract Carnoys solution has been widely undertaken as adjunctive therapy for benign odontogenic tumors. Although its outcomes were highly investigated, little information is available regarding its mechanism of action and the role of chloroform in composition. The aim of this study was to characterize Carnoys solution with and without...

The Odontogenic keratocyst (OKC) is a benign lesion of the Oro-facial region having distinct clinicopathological features, high propensity for recurrence and characteristic aggressive behaviour. It commonly involves the mandible while maxilla is relatively unusual location. The clinico-histo-pathological characteristics and subsequent of OKC in a 30 years old male patient with maxillary involvement has been discussed herewith.. ...

Odontogenic keratocyst of the angle and ramus of the mandible - a case report-JDS-Print ISSN No:-2320-7302 Online ISSN No:-2393-9834Article DOI No:-10.18231,Journal of Dental Specialities-IP Innovative Publication Pvt Limited, Medical Journals Publication, Open Access Journals, Print Journals,Indian Journals, Surge

Pseudovascular squamous cell carcinoma (SCC) is a rare variant of SCC characterized by acantholysis and necrosis with preservation of vascular-like cords and spaces mimicking glands or vascular differentiation. Only three cases of this variant in the oral cavity have been reported in the literature. However, none of these cases were eosinophil-rich, which is considered to be a good prognostic indicator for conventional SCC. We report one case of an eosinophil-rich pseudovascular adenoid SCC in the oral cavity. A 38-year-old previously healthy African-American female presented with an enlarging inner left cheek mass with overlying ulcer of 2 months duration. A computed tomography scan with contrast demonstrated a large irregularly outlined peripherally enhancing mass located between the anterior margin of the ramus of the left mandible and maxilla protruding outward. An incisional biopsy was performed followed by a wide local excision 3 weeks later. She recovered well postoperatively but refused ...

Introduction: Odontogenic tumors (OTs) are a group of heterogeneous lesions derived from epithelial or ectomesenchymal tissues or both, which are part of the tooth-forming apparatus. They range from hamartomatous or nonneoplastic tissue proliferations to malignant neoplasms with metastatic capacity. OTs are comparatively rare, comprising about 4.79% of all oral and maxillofacial biopsy specimens diagnosed. Several retrospective studies carried out in Africa, Asia, Europe and America, show that differences exist in the relative frequency of the various histologic types. Very few studies are reported among Asians, especially from the Indian subcontinent. Hence, the present study is designed to determine the frequency of the OTs and compare them with reports of various other part of the world. Study Design: A retrospective study was carried out with the ethical clearance and permission from the authority. The histopathology records from the Department of Oral Pathology and Microbiology, within the ...

Arzi B, Murphy B, Cox DP, Vapniarsky N, Kass PH, Verstraete FJM. (2010) Presence and quantification of mast cells in the gingiva of cats with tooth resorption, periodontitis and chronic stomatitis. Archives of Oral Biology 55(2): 148-154. Arzi B, Murphy B, Baumgarth N, Vapniarsky N, Nemec A, Naydan D, Cox DP, Verstraete FJM. (2011) Analysis of immune cells within the healthy oral mucosa of specific pathogen free cats. Anatomia, Histologia, Embryologia 40(1): 1-10. Fiani N, Verstraete FJM, Kass PH, Cox DP. (2011) Clinicopathologic characterization of odontogenic tumors and focal fibrous hyperplasia in dogs: 152 cases (1995-2005). Journal of the American Veterinary Medical Association 238(4): 495-500. Fiani N, Arzi B, Johnson EG, Murphy B, Verstraete FJM. (2011) Osteoma of the oral and maxillofacial region in cats: 7 cases (1999 - 2009). Journal of the American Veterinary Medical Association 238(11): 1470-1475. Arzi B, Murphy B, Nemec A, Vapniarsky N, Naydan DK, Verstraete FJM. (2011) Expression ...

Probable cementoblastoma. Differential includes: ossifying fibroma Paget disease (less likely as patient is 24 years old) previous osteomyelitis

The external face operation in our example fails because some important global information is missing from the local processing. The processes need some data that is not local to them, but they do not need all the data. They only need to know about cells in other partitions that are neighbors to the local cells. We can solve this local/global problem with the introduction of ghost cells. Ghost cells are cells that belong to one partition of the data and are duplicated on other partitions. The introduction of ghost cells is performed through neighborhood information and organized in levels. For a given partition, any cell neighboring a cell in the partition but not belonging to the partition itself is a ghost cell 1. Any cell neighboring a ghost cell at level 1 that does not belong to level 1 or the original partition is at level 2. Further levels are defined recursively. We define ghost cells in this way because it provides a simple distance metric to the cells of a partition and allows filters ...

Oh dear. I need to try to condense my story. Around 1999 and xray showed up a dark spot when I went for a cleaning. I was referred to and ortho who scheduled the removal of the k cyst. My regular dentist decided to use me to teach another how to do a root canal and used the tooth above that cyst. I heard him say, after he drilled it out that he would NOT clean our the residue as usual. Well, the surgeon had said he could save that tooth and the dentist caused a horrible infection and after a 4 day in the hospital on strong antibiotics and weeks at home on the same orally, my surgeon and I agreed I was as good as I was gonna get and the infection was to deep for the antibiotic to reach. He removed the cyst at his office and the tooth as well had to be removed thanks to my regular dentist at Western Dental in San Diego. A few years passed and I thought I felt a small lump I had different insurance and went to a Kaiser Permanente ENT. He said yes its back and I can get it out. He did. This was ...

Oh dear. I need to try to condense my story. Around 1999 and xray showed up a dark spot when I went for a cleaning. I was referred to and ortho who scheduled the removal of the k cyst. My regular dentist decided to use me to teach another how to do a root canal and used the tooth above that cyst. I heard him say, after he drilled it out that he would NOT clean our the residue as usual. Well, the surgeon had said he could save that tooth and the dentist caused a horrible infection and after a 4 day in the hospital on strong antibiotics and weeks at home on the same orally, my surgeon and I agreed I was as good as I was gonna get and the infection was to deep for the antibiotic to reach. He removed the cyst at his office and the tooth as well had to be removed thanks to my regular dentist at Western Dental in San Diego. A few years passed and I thought I felt a small lump I had different insurance and went to a Kaiser Permanente ENT. He said yes its back and I can get it out. He did. This was ...

Principal Investigator：MOGI Kenji, Project Period (FY)：1998 - 1999, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Surgical dentistry

of quantitative polymerized chain reaction array of autophagosome formation related genes revealed that GABARAPL2 was prominently upregulated while expression of other ATG8 family members were moderately increased after tooth cavity preparation. In addition, human DPCs incubated in differentiation medium predominantly upregulated MAP1LC3C, which selectively decreased by 3MA but not by autophagy enhancer trehalose. Knock-down of MAP1LC3C using shRNA resulted in strong downregulation of dentin matrix protein 1 and DSPP as well-known odontogenic marker compared to knock-down of MAP1LC3B during odontogenic differentiation process of human DPCs ...

Originally presented at the AST Cutting Edge of Transplantation (CEoT) Meeting in February 2021, this rebroadcasted session will provide insight to challenges facing kidney and liver transplant clinicians and how biomarkers are the key to assisting with safer minimization strategies. Also includes is a preview to a novel addition of infectious disease monitoring to donor derived cell free DNA testing. This is not an official function of the CEoT Meeting and is not endorsed by the AST.

Androurologist in Kot Khawaja Saeed Lahore - Find a Androurologist Near You at Hamariweb.com. List of best Androurologist in Kot Khawaja Saeed Lahore doctors and specialist for the treatment.

Jaundzimušajiem piemērotais Omni 360 ir aprīkots ar visām pārnēsāšanas pozīcijām. Omni 360 aug kopā ar bērnu no 1.nedēļas līdz 48 mēnešu vecumam.

Jul 02, · Würmer, die wie Regenwürmer Kann das ein Parasit meiner Katze sein oder hat sie ihn von draußen mit reingebracht? wenn sie aus dem Kot herauskommen.

Če postopka (klasično križanje vs gensko modificiranje) zreduciraš na sestavne gradnike, torej na DNA, sta si postopka v bistvu podobna. Razlika je, da je klasično križanje podobno možganski operaciji, kjer kirurg uporablja sekiro, genetski inženiring pa je ista operacija z uporabo mikroskopa in ostalih modernih medicinskih inštrumentov. Pri klasičnem križanju uporabiš za starše primerke, ki imajo želene lastnosti in upaš, da bo določen delež potomcev izrazil lastnosti obeh staršev. To potem plemenitiš in križaš naprej, dokler nisi približno zadovoljen z rezultatom. Na molekulskem nivoju to pomeni rekombiniranje velikih področij DNA, pri čemer upaš na majhne spremembe in izločanje neželenih alelov. Kot rečeno, možganska operacija s sekiro. Poleg tega si pri križanju omejen na obstoječe gene in na naključne mutacije. Čisto možno je, da bi zaradi naključne mutacije koruza dobila gen, ki bi proizvajal Bt toksin (pustimo zdaj detajl, da bi najverjetneje takšna ...

Športni park Grosuplje se nahaja na JZ delu mesta Grosuplje, med Adamičevo cesto na severu, Sončnimi dvori na jugovzhodu in Brezjem pri Grosupljem na jugozahodu. Zaradi neposredne bližine železniške postaje in središča mesta na eni strani ter potokom Bičje kot povezave na Radensko polje na drugi se ponuja kot odlična lokacija za družbeno rekreacijsko stičišče, obenem pa služi kot izhodišče prebivalcem za odkrivanje čudovitega sveta narave, ki jih obdaja.. Anketni vprašalnik lahko izpolnite na povezavi https://forms.gle/2fUzsr7PREw6C6RZ6, do četrtka, 31. 12. 2020.Hvala, ker prispevate k soustvarjanju našega mesta.. ...

Pogledati podrobneje.. Prvi vtis je zelo pomemben, zato se moramo prepričati, da le-ta ni napačen. To velja tako v osebnem kot tudi v poslovnem okolju, kjer nas napačen vtis lahko odvrne od odlične priložnosti ali pa napelje k slabi odločitvi.. POD LUPO je storitev, ki bi jo lahko poimenovali kot drugo mnenje. Drugo mnenje, ki vam bo v pomoč pri vaših poslovnih odločitvah.. ...

Težave s kroničnim venskim popuščanjem se lahko pojavijo ne glede na življenJsko obdobje, na pričetek, težo in potek bolezni pa vplivajo tako genetična predispozicija, kot zunanji dejavniki, kot so nosečnost, stoječe delo, izpostavljanje toploti, uživanje zdravil in kontracepcije, težave s ščitnico idr.. Preveri ...

To so ugotovili v raziskavi, kjer so ugotavljali povezavo med depresijo in (ne)uporabo kondomov pri enskah. tudija dokazuje, da enske, ki so bile (ve krat) izpostavljene semenu, redkeje zapadajo v depresije. Izvajalci tudije kljub temu ne zagovarjajo neuporabe kondomov, saj bi neza elena zanositev ali spolno nalezljiva bolezen poslab ala psihi no po utje veliko bolj kot pomanjkanje sperme.. Raziskava je bila narejena na vzorcu 293 tudentk. e je testiranka nabrala ve kot 17 to k, je to pomenilo, da je depresivna ...

Trenutno za zdravljenje raka pridobivajo na pomenu različne lokalne ablacijske terapije, ki v bistvu lahko delujejo kot in situ vakcine, saj povzročijo sproščanje tumorskih antigenov hkrati z signali nevarnosti, kar lahko sproži nastanek endogenega imunskega protitumorskega odgovora. Pred kratkim smo objavili model, kako bi lahko uporabili elektrokemoterapijo (ECT), ki je vrsta lokalne ablacijske terapije, kot in situ vakcinacijo v kombinaciji z elektrogenskim prenosom (GET) interleukina 12, s katerim bi pospešili sprožen imunski odziv proti tumorskim antigenom sproščenim iz ubit tumorskih celic (Sersa et al., 2015). Uporabnost modela smo potrdili v klinični raziskavi na psih (Cemazar et al., 2016), ampak natančni mehanizmi opažene protitumorske učinkovitosti na nivoju vpletenosti imunskih celic še niso jasni. V odobrenem projektu bo naš cilj spremljati imunski odgovor po ECT in EGT z IL-12 ter njuni kombinaciji z intravitalnim slikanjem v realnem času, ter ga korelirati s ...

P7 je ena Ledlenserjevih najbolj ikoničnih svetilk, zato so se odločili, da jo nadgradijo. P7 Core kot naslednik P7 ima še vedno eno najbolj inovativnih…

Van most egy j mel m s h t az asszonyra is sz ks g lenne. De amikor mondtam hogy mi lenne a dolga elkezdett rik csolni hogy a sz n r kot okoz meg ilyesmik s 5 r ja a h l szob ban gubbaszt s n ...