Autori: L. Copolovici and U. Niinemets. Editorial: Chemosphere, 61, p.1390-1400, 2005.. Rezumat:. Cuvinte cheie: Monoterpenes; Henrys law constant; Octanol/water partition coefficient; Partition coefficients; Temperature dependence. ...
According to the REACH Regulation, Annex VIII, Column 2, the study does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient). Direct Blue 199 is expected to have a low potential for absorption, on the basis of the partition coefficient; the log Pow was determined to be negative. The organic carbon-water, suspended matter-water and soil-water partition coefficients were in any case estimated, using EUSES v.2.1.2, in order to derive the PNECs for sediment and soil, according to the equilibrium partitioning method. Furthermore, for the same purpose the soil-water and suspended matter-water partition coefficients were also estimated: Suspended matter-water partition coefficient: 0.917 Soil-water partition coefficient: 0.22 [LogKoc: -0.17] ...
CORROSIVITY: Corrosive to iron DENSITY: 1.735 @ 20 DEG C PH: pH 7.2 in tap water. SOL: PRACTICALLY INSOL IN WATER; SOL IN MOST ORGANIC SOLVENTS ; SOL IN XYLENE, KEROSENE, CHLOROFORM, ACETONE, & ALCOHOL ; 200 g/l in ethyl acetate @ 20 deg C ; 200 g/l in dichloromethane @ 20 deg C ; 200 g/l in toluene @ 20 deg C ; 65 g/l in ethanol @ 20 deg C ; 24 g/l in hexane @ 20 deg C MP: 70-100 DEG C; STABLE TOWARD DIL MINERAL ACIDS; HYDROLYZED RAPIDLY BY ALKALIES; COMMERCIAL PRODUCT IS A MIXTURE OF ALPHA-ISOMER, MP: 108-110 DEG C, & BETA-ISOMER, MP: 208-210 DEG C /TECHNICAL/ DECOMP IN PRESENCE OF ACIDS & ALKALIES TO FORM SULFUR DIOXIDE; CORROSIVE TO IRON; ODOR OF HEXACHLOROCYCLOPENTADIENE & MAY HAVE SLIGHT SULFUR DIOXIDE ODOR, TAN, SEMI-WAXY SOLID /TECHNICAL/ HYDROLYZES SLOWLY ON CONTACT WITH WATER COLORLESS CRYSTALS /ALPHA-ISOMER/ Octanol/water partition coefficient: log Kow= 3.55 /alpha-Endosulfan/; log Kow= 3.62 /beta-Endosulfan/ Solubility at 22 deg C and a pH 7.2 in tap water; alpha-Endosulfan: 0.15 ...
According to REACH Annex VIII, Point 9.3.3 (Adsorption/desorption screening), the study needs not be conducted if: - based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient); or - the substance and its degradation products decompose rapidly. With a log Kow of 2.75, a study using animals is not justified. Butylal adsorption/desorption was estimated by KOCWIN v2.00 software to a Koc value of 184.1 L/kg. Therefore butylal would be moderately mobile in soil. [LogKoc: 2.27] ...
Liquid aqueous solubility (S(w,L)), octanol/water partition coefficients (K(ow)), liquid vapor pressure (P(v,L)), and Henrys law constants (H(c)) were estimated for 20 methylated naphthalenes ranging from monomethyl to tetramethylnaphthalenes. Chromatographic methods were used for the estimation. Chromatographic retention measurements were conducted for 11 reference compounds and regressions were fit between the retention indices and the physicochemical properties. HPLC octadecylsilyl column with acetonitrile/water eluent was used for the estimation of S(w,L) and K(ow). Two GC columns, HP5-MS and a more hydrophobic HP-1, were tested for the estimation of P(v,L). Measured retention indices for the methylated naphthalenes were entered to the regression equations to calculate the physicochemical properties for these compounds. Literature values, where available, were used to validate the calculated values. The method accurately estimated the physicochemical properties. Estimated S(w,L) and P(v,L)
The category members display similar physicochemical and environmental fate properties. Since category members are all organic salts or internal salts, they exhibit high degree of dissociation in water, very low octanol/water partition coefficients, high melting points, do not boil without decomposing and do not exert vapour pressure. In addition, category members are stable to hydrolysis. As a result of the stilbene portion of the molecule, common to all category members, these fluorescent whitening agents have an UV absorption maximum between 340 to 360 nm in water, which makes them subject to photo-degradation in the hydrosphere. All category members tested are appreciably soluble in water. Water solubility tends to increase with increasing numbers of sulfonate groups on the molecule. Existing data for the substances indicate that they exert similar effects with respect to aquatic and mammalian toxicology. Available studies suggest that the category members are of low toxicity to fish, ...
Dettenmaier, EM, Doucette WJ, Bugbee, B. 2008. Re-examining the relationship between plant uptake of organic chemicals and octanol water partition coefficients. Presented in a platform session at the 18th Annual AEHS Meeting and West Coast Conference on Soils, Sediments, and Water. San Diego, CA, March. 10-13.. ...
Synonyms: perchlorobenzene, pentachlorophenyl chloride, phenyl perchloryl Trade names: Amatin, Anticarie, Bunt Cure, Bunt-No-More, Co-op Hexa, Granox NM, Julins Carbon Chloride, No Bunt, No Bunt 40, No Bunt 80, No Bunt Liquid, Sanocide, Smut-Go, Snieciotox, HexaCB 2.2 Physical and chemical properties Some physical and chemical properties of HCB are listed in Table 1. At ambient temperature, HCB is a white crystalline that is virtually insoluble in water, but is soluble in ether, benzene and chloroform (NTP, 1994). It has a high octanol/water partition coefficient, low vapour pressure, moderate Henrys Law constant and low flammability. Technical grade HCB is available as a wettable powder, liquid and dust (NTP, 1994). Technical grade HCB contains about 98% HCB, 1.8% pentachlorobenzene and 0.2% 1,2,4,5- tetrachlorobenzene (IARC, 1979), and it is known to contain a variety of impurities, including hepta- and octachlorodibenzofurans, octachlorodibenzo- p-dioxin and decachlorobiphenyl (Villanueva ...
A number of different strategies have been explored to therapeutically modulate tumor oxygenation. The studies described here show that the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib improves oxygenation within A431 squamous cell carcinoma xenografts. Using in vivo PET imaging with the hypoxia marker FAZA, it was seen that treatment with gefitinib reduced hypoxia in A431 xenografts in comparison with untreated control tumors. Importantly, serial PET imaging studies were able to show that gefitinib reduced hypoxia compared with pretreatment levels. These findings were verified in a parallel experiment in which hypoxia was assessed using pimonidazole binding at time points corresponding with the PET studies.. In vivo imaging of hypoxia was conducted using the PET hypoxia imaging agent FAZA. This compound displays different physical properties to fluoromisonidazole, in particular, a lower octanol/water partition coefficient, indicating the potential for more rapid ...
also i know that an increase in molecular weight is related to an increase in the size of the molecule and the larger the molecule the less permeable the membrane is to that molecule, so does that mean that as the molecular weight increases, the less permeable the membrane becomes and therefore it takes more time for hemolysis ...
(2E)-1-oxo-1-(1-piperidinyl)-2-octen-4-one - chemical structural formula, chemical names, chemical properties, synthesis references
Permeability coefficients (P m ) across planar egg lecithin/decane bilayers and bulk hydrocarbon/water partition coefficients (K w→hc) have been measured for 24 solutes with molecular volumes, V, varying by a factor of 22 and P m values varying by a factor of 107 to explore the chemical nature of the bilayer barrier and the effects of permeant size on permeability. A proper bulk solvent which correctly mimics the microenvironment of the barrier domain was sought. Changes in P m /Kw→hc were then ascribed to size-dependent partitioning and/or size-dependent diffusivity. The diffusion coefficient-size dependency was described by D barrier = D 0 /V n . When n-decane was used as a reference solvent, the correlation between log P m /K w→hc and log V was poor (r = 0.56) with most of the lipophilic (hydrophilic) permeants lying below (above) the regression line. Correlations improved significantly (r = 0.87 and 0.90, respectively) with more polarizable solvents, 1-hexadecene and 1,9-decadiene. Values of
Partition coefficients - logP, and its pH-dependent pair, logD - are crucial in estimating the distribution of drugs in the human body. Drugs with higher partition coefficients modelled in an octanol/water system are more likely to be distributed in the hydrophobic tissues like blood. However, molecules with low partition coefficients can mostly be found in lipophilic areas of the human body, like lipid bilayers of cells. The quality of the logP/logD prediction can be enhanced by incorporating measured logP/logD data through training ...
i) LIPOPHILICITY (e.g., LogD and cLogP). Historically, lipophilicity was the first of the structural properties to be recognized as important for CNS penetration. As early as 1897, Overton observed correlations between oil-water partition coefficients and narcotic potencies of a series of compounds in tadpoles [4]. By the 1960s, Hansch introduced the octanol/water system, which became the standard for measuring partition coefficients, and he demonstrated that blood-brain barrier permeation is optimal when the LogP values are in the range of 1.5-2.7, with the mean value of 2.1. In line with Hanschs findings, the mean value for cLogP for 74 marketed CNS drugs has been reported by Leeson to be 2.5. A number of different guidelines for predicting BBB permeation based on structural properties have been proposed, which suggests preferred ranges for LogP of between 1 and 5 (Table 1). In addition to permeability, lipophilicity plays an important role in other pharmacokinetic properties that may affect ...
For the evaluation of the role of substituents of ar-turmerone for its anticancer activity, ar-turmerone (1a) and its analogs like 2-methyl-6-(4-methyphenyl)-2-octen-4-one (1b), 2-methyl-6-phenyl-2-hepten-4-one (1c), 2-methyl-6-phenyl-2-octen-4-one (1d) and 2 methyl-6-(trans-4-methylcyclohexyl)-2-...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The BCD is a file, not a partition. The BCD file would be included if the partition that contained it was included. For example, if the System Reserved partition is used then you would want to include the System Reserved partition in your backup ...
Objectives The occupational hazard of chemical absorption via dermal route was frequently assessed by evaluating the skin permeability (Kp) of chemical. In addition to in vitro testing using human skin, the quantitative structure-activity relationship (QSAR) has been employed as an alternative source to providing Kp. In the early Kp QSARs the octanol-water partition coefficient (log KOW) and molecular weight (MW) were commonly applied as dominant properties to describe transdermal transport of chemical. This study examined the efficacy of log KOW-/MW-based QSARs in Kp prediction.. ...
VCPL, Hyderabad India offers Octan-1-ol HPLC CAS # 111-87-5. We are best Octanol, Octan-1-ol HPLC, Octyl alcohol, 1-Octanol, Octan-1-ol HPLC manufacturer
This study evaluates the potential application of micellar liquid chromatography (MLC) to predict skin permeation with a series of model compounds. MLC has previously been found to be useful in the prediction of partition coefficient values (logP) for pharmaceutical compounds, yet has not been incorporated in skin permeability models prior to this work. This article provides statistically supported data that this technique enhances the ability to predict the permeability of similar drugs through the skin (Kp). The replacement of a traditional physicochemical parameter, namely the octanol-water partition coefficient (logPow) with a chromatographically determined value (logPmw), results in a quantitative partition-permeability relationship that is robust to variation. MLC offers many benefits compared with the traditional techniques employed to obtain logP values.. ...
8-benzyl-8-azabicyclo[3.2.1]octan-3-endo-ol, 95%, Maybridge Amber Glass Bottle; 5g 8-benzyl-8-azabicyclo[3.2.1]octan-3-endo-ol, 95%, Maybridge Benzothien to Benzyla...
A poster (P165) presented at ASMS 2017, Indianapolis, discusses three sample preparation methodologies for 52 drug analytes, and presents evaluations of recovery, matrix effects and process efficiency. While "dilute and shoot" methods are easy and affordable, they can result in shortened LC column lifetimes and increased MS instrumentation downtime. Matrix effects can also effect sensitivity and overall method performance. Supported Liquid extraction (SLE) and Solid Phase Extraction (SPE) provide cleaner samples for LC-MS/MS and more robust clinical assays.. Successful sample preparation method development requires understanding the retention mechanism of the analytes in the assay. The octanol-water partition coefficient (logP) and acid dissociation constant (pKa) of the compounds of interest are important properties that can guide sample preparation strategy and optimization of method conditions.. Conclusions. ...
octan-2-ol 123-96-6 MSDS report, octan-2-ol MSDS safety technical specifications search, octan-2-ol safety information specifications ect.
A mathematical model has been developed that is based on the molecular mechanism of diffusion and that explicitly incorporates the non-uniform structure of the stratum corneum. The model is used to predict permeability coefficients of chemicals based on their molecular weight (MW) and octanol-water partition coefficient (P).
Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = 3.16 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 183.62 (Adapted Stein & Brown method) Melting Pt (deg C): -18.67 (Mean or Weighted MP) VP(mm Hg,25 deg C): 0.809 (Mean VP of Antoine & Grain methods) Water Solubility Estimate from Log Kow (WSKOW v1.41): Water Solubility at 25 deg C (mg/L): 68.98 log Kow used: 3.16 (estimated) no-melting pt equation used Water Sol Estimate from Fragments: Wat Sol (v1.01 est) = 95097 mg/L ECOSAR Class Program (ECOSAR v0.99h): Class(es) found: Esters Silanes (alkoxy) Henrys Law Constant (25 deg C) [HENRYWIN v3.10]: Bond Method : 5.12E-003 atm-m3/mole Group Method: Incomplete Henrys LC [VP/WSol estimate using EPI values]: 3.401E-003 atm-m3/mole Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]: Log Kow used: 3.16 (KowWin est) Log Kaw used: -0.679 (HenryWin est) Log Koa (KOAWIN v1.10 estimate): 3.839 Log Koa (experimental database): None ...
Microbial transcription modulator NusG interacts with RNA polymerase and termination factor rho, displaying striking functional homology to eukaryotic Spt5. The protein is also a translational regulator. We have determined crystal structures of Aquifex aeolicus NusG showing a modular design: an N-terminal RNP-like domain, a C-terminal element with a KOW sequence motif and a species-specific immunoglobulin-like fold. The structures reveal bona fide nucleic acid binding sites, and nucleic acid binding activities can be detected for NusG from three organisms and for the KOW element alone. A conserved KOW domain is defined as a new class of nucleic acid binding folds. This module is a close structural homolog of tudor protein-protein interaction motifs. Putative protein binding sites for the RNP and KOW domains can be deduced, which differ from the areas implicated in nucleic acid interactions. The results strongly argue that both protein and nucleic acid contacts are important for NusGs functions ...
Substituent constants and regression analysis have been used to correlate the localization of substituted benzeneboronic acids in brain and tumor tissue of mice. It is shown that localization in the brain can be rationalized in terms of one parameter, π, obtained from octanol: water partition coefficients. Localization in the tumor depends on an additional electronic parameter, δ. Localization in the boronic acid series is compared with biologic activity in a series of barbituric acids.. ...
3-[(3S)-octan-3-yl]phenol | Real Time Predictor can calculate by using any chemical identifier or molecular structure on website and provide estimated physicochemical property data based on the reliable QSPR and ANN.
2-(4-Allyl-3-pyridin-3-yl-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl)-6,8-dioxa-bicyclo[3.2.1]octan-4-one | C16H16N4O3S | CID 535453 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
5-Amino-1-[6-[(E)-4-(dimethylamino)but-2-enoyl]-6-azaspiro[3.4]octan-2-yl]-3-(4-phenoxyphenyl)pyrazole-4-carboxamide | C29H34N6O3 | CID 89968991 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
(4-aminobicyclo[2.2.2]octan-1-yl)methanol hydrochloride |p|SPC Code: SPC-a553|/p||p|CAS RN: 105176-66-7|/p||p|Smiles: Cl.OCC12(CCC(N)(CC1)CC2)|/p||p|Formula: HCl.C9H17NO|/p||p|MolWeight: 191.701|/p||p|Purity: 95|/p|
Volatile off-flavor compounds are present in beef. Using purge and trap gas chromatography and mass spectrometry, some volatile compounds were shown to have different concentrations in normal-flavored beef, compared to samples with liver-like off-flavor. Most of the compounds, like pentanol, hexanal, hexanol, 1-octen-3-ol, and nonanol, are associated with lipid oxidation. The compounds, β-pinene and 1-octen-3-ol were in higher concentration in the liver-like samples in all muscles tested. Several, small, unidentified peaks also differed between samples. Determination of the possible origins of these compounds may improve the quality and consistency of beef products.
EWGs Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases.
We determined the ability of orexin A and orexin B, recently discovered endogenous appetite enhancers, to cross the blood-brain barrier (BBB) of mice. Multiple time-regression analysis showed that an i.v. bolus of125I-orexin A rapidly entered the brain from the blood, with an influx rate (Ki = 2.5 ± 0.3 × 10−4 ml/g·min) many times faster than that of the 99mTc-albumin control. This relatively rapid rate of entry was not reduced by administration of excess orexin A (or leptin) or by fasting for 22 h, even when penetration into only the hypothalamus was measured. Lack of saturability also was shown by perfusion in blood-free buffer. HPLC revealed that most of the injected125I-orexin A reached the brain as intact peptide. Capillary depletion studies showed that the administered peptide did not remain bound to the endothelial cells comprising the BBB but reached the brain parenchyma. Efflux of 125I-orexin A from the brain occurred at the same rate as 99mTc-albumin. The octanol/buffer partition ...
Looking for SPECTRUM Amino 1 Octanol,1g (26XF53)? Graingers got your back. Price:$148.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
Sigma-Aldrich offers Aldrich-218405, 3-Octanol for your research needs. Find product specific information including CAS, MSDS, protocols and references.
Purified Recombinant Human TRPA1 Protein, His-tagged from Creative Biomart. Recombinant Human TRPA1 Protein, His-tagged can be used for research.
If one were asked to name the most important among the factors that will influence drug absorption and penetration to the site of action, one would have to name the lipid-water partition coefficient, which is determined by the pKa of the drug and the pH of the body fluids. Put simply, in solution the weak acids and bases will be present in some combination of ionised and non-ionised forms. Of these incompletely ionised substances, the non-ionised forms will be lipid soluble, whereas the ionised forms will not. The proportion of the ionised to non-ionised molecules is determined by the pH of the solution and the pKa of the drug (pKa being the pH at which concentration of ionised and non-ionised forms is equal).
The crystal structure of the title bicyclic lactam, C6H9NO4, has firmly established the stereochemistry of the branched -sugar amino acid scaffold ...
Determining the Apparent Volume of Distribution (this particular paragraph is intended to be of interest to those with great interest in math or pharmacology)... We can determine apparent volume of distribution (Vd) by dividing the dose of drug administered by the amount of the drug in the bloodstream following distribution of the drug.. Suppose that we injected someone with a total dose (i.v. bolus) of 10 grams of aspirin. Following distribution, we found a plasma concentration of 0.5 mg/ml in plasma. If we divide 10 g (10,000 mg) by 0.55 mg... that is a dilution factor of... 10,000 divided by 0.5 = 20,000. But we know that a mg of water has a volume of 1 ml. That means... our drug must have been distributed to a theoretical volume of of 20,000 mls or 20 liters of water. Our patient had a body mass of 50 kg. When we divide the theoretical volume of water in which the aspirin was distributed (20 L) by the mass of the patient (50 kg), we get a theoretical volume of distribution of 0.4 L/kg of ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Presentation by Sirius Analytical covering measurement of pKa, LogP, LogD, Solubility, Supersaturation and precipitation kinetics. For more details visit www.s…
Here, industry expert Tony OLenick explains the difference between solubility and partition coefficient, as the understanding can lead to a better delivery of a formulations materials.
1-Octen-3-ol, octenol for short and also known as mushroom alcohol,[1] is a chemical that attracts biting insects such as mosquitoes. It is contained in human breath and sweat, and it was once believed that insect repellent DEET works by blocking the insects octenol odorant receptors.[2][3] 1-Octen-3-ol is a secondary alcohol derived from 1-octene. It exists in the form of two enantiomers, (R)-(-)-1-octen-3-ol and (S)-(+)-1-octen-3-ol. ...
Oyster mushrooms do not taste like oysters but rather get their name from their resemblance to the shellfish. Oyster mushrooms are among the most abundant of wild mushrooms. They can be found throughout the year, most often on the trunks of dead trees.. Oyster mushrooms are the third largest cultivated mushroom. China, the world leader in Oyster production, contributes nearly 85% of the total world production of about a million tonnes.. Oyster mushrooms are grown in bags of composted sawdust. The bags are sterilized, then inoculated with mushroom spawn (seed) placed inside the bag.. A characteristic of oyster mushrooms is that they have an eccentric (off-centre) stem or sometimes even no stem at all. Oyster mushrooms are very likely the most perishable of mushrooms. They must be kept between 1 and 4 degrees C.. Their colour can vary slightly depending on variety, from pale gray, to light beige, and sometimes pink or yellow. Oyster Mushrooms are similar to the Chanterelle with a more delicate ...
Amaryl puede ser administrado en combinación con antidiabéticos orales no betacitotrópicos. Amaryl puede ser usado concomitantemente con metformina cuando la dieta, el ejercicio, y Amaryl o metformina sola no dan jakarta resultado un oxycodone hcl powder glicémico adecuado. Amaryl también está indicado para uso en. Información importante sobre alguno de los componentes de Amaryl 2 mg comprimidos: Este medicamento contiene lactosa. Si su médico le ha indicado que padece una intolerancia a oxycodone hcl powder azúcares, consulte con él burns de tomar este medicamento. Uso de otros medicamentos: Informe a su médico o farmacéutico si. Descending Benadryl (Diphenhydramine) for Injection Report. The chemical formula is 4, 5α-epoxyhydroxymethoxymethylmorphinanone hydrochloride. Oxycodone is a white, odorless crystalline powder derived from the opium alkaloid, thebaine. Oxycodone hydrochloride dissolves in water (1 g in 6 to 7 mL). It is slightly soluble in alcohol (octanol water partition ...
An experiment was undertaken by Tanniet al. (1992) to determine the octanol-water partition coefficient of 2-(2-methylpropoxy)ethanol and thirteen other ethylene glycol ethers as part of a study evaluating structure-toxicity relationships. The estimation (solubility ratio) methodology followed was according to that outlined by Tanni and Hashimoto (1982) and involved analyses by gas-liquid chromatography with flame ionisation detection and a glass column. Under the conditions of the experiment, 2-(2-methylpropoxy)ethanol was reported to be evidently separated from the organic (n-octanol) phase that had been dissolved in water. Following analyses, a log Kow of 0.75 was determined for 2-(2-methylpropoxy)ethanol. ...
For each SSRI, laboratory environmental fate measurements will include the following: aqueous solubility; octanol-water partition coefficient (Kow); acid dissociation constant (pKa); soil adsorption coefficient (Koc); hydrolysis and aqueous direct photolysis rates at pH 5,7and 9; indirect photolysis rates including the hydroxyl radical rate constant; irradiated and dark aerobic-aquatic metabolism; and ready biodegradability. Major degradation products will be identified wherever possible. The occurrence of each SSRI and major metabolites/degradation products will be measured over one year in raw and treated wastewater, and receiving water at sub-ppb levels. Potential loads to waste treatment facilities will be assessed through surveys of numbers of prescriptions filled by local pharmacies. Acute toxicity and chronic exposure tests for survival and reproduction will be conducted with Ceriodaphnia following EPA protocols on each SSRI as well as on raw sewage water and treated effluent. Toxicity ...
When considering the use of medicinal mushrooms, one doesnt have to venture into the deep woods! Consider the elegant Oyster Mushroom commonly found in grocery stores, and fine food suppliers. "Pleurotus Ostreatus" is its latin name. This delightful and tasty mushroom produces a form of Lovastatin (a drug approved in 1987 by the FDA for treating excessive cholesterol blood levels). This specific constituent is more concentrated in the mature gills than the stems.. Oyster mushrooms accelerate the plasma turnover of cholesterol resulting in a general reduction in base lines. One study showed that plasma cholesterol turnover rates was boosted by 50%. In addition there was a 25% decrease in the liver compared to controls. (Bobek et al., 1995). Whilst it is certainly true that many woodland mushrooms share cholesterol reducing properties, Oyster mushrooms are a bit more noteworthy.. In addition this mushroom has potent tumor inhibiting properties, and has strong anti oxidant effects which may be ...
This is a single-arm, open-label, 8-week proof of concept pilot study in 20 subjects to determine if there are detectable lipid-lowering effects of oyster mushrooms in patients with HIV and hyperlipidemia who are taking Kaletra (a ritonavir-containing HAART regimen). The study will also assess whether the concurrent administration of oyster mushrooms and such regimens is safe, and investigate the mechanism of action whereby oyster mushrooms may exert their antihyperlipidemic effect ...