The Community indicative occupational exposure limit values are established as implementation of Council Directive 98/24/EC.Member States shall establish national occupational exposure limit values for the chemical agents listed in the Annex, taking into account the Community values.
Supplementary Tables S1-S6 - Supplementary Tables S1-S6. Table S1. Number and percentage of cases and control with exposure to each occupational agent. Table S2. SNP-level significant occupational exposure interactions for known occupational lung carcinogens. Table S3. SNP-level significant occupational exposure interactions for occupational exposures with increased risk for lung cancer not clear. Table S4. Gene-level significant occupational exposure interactions for occupational exposures with increased risk for lung cancer not clear. Table S5. Significant genomic regions for occupational exposure interactions and the significant genes identified in these regions. Table S6. Main categories of proteins coded by the significant genes identified by the gene-occupational interaction analyses ...
The Dutch Expert Committee on Occupational Safety has released its draft recommendations on occupational exposure limits for bisphenol A and for cadmium and its inorganic compounds. Regarding bisphenol A, DECOS considered there to be very limited evidence to support a non-monotonic dose-response relationship and therefore recommended a health‑based recommended occupational exposure limit (HBROEL) of 3.3 mg/m3 (inhalable fraction), based on a 13‑week inhalation study in rats, the critical effect being local toxicity in the nasal cavity. For cadmium and its inorganic compounds, DECOS reviewed the 2017 recommendation of the Scientific Committee for Occupational Exposure Limits (SCOEL), and considered the scientific basis of its OEL (of 1 µg/m3, inhalable fraction) to be insufficient. DECOS instead supported a previously‑defined biological limit value in the urine of 2 µg cadmium/g creatinine for the protection against kidney effects, and an OEL of 4 µg/m3 to prevent adverse effects on the ...
Asbestos and hazardous materials removal specifications and project management.. Health Safety Consultants occupational hygiene team operates within applicable industry code of conduct and committed to quality deliverables that meet industry standards. The team members hold memberships with professional bodies such as the Australian Institute of Occupational Hygienists (AIOH) and the Safety Institute of Australia (SIA). We have years of experience working with numerous industries including manufacturing, construction, facilities management, local, state and federal government and defence. Health Safety Consultants occupational hygiene team has established a very successful company providing occupational hygiene services with a reputation for professionalism, integrity, competence, and customer satisfaction. We are proud that this reputation is based on our systems and people that make our service possible. Each and every day we work hard to better our service that will ultimately better our ...
TY - JOUR. T1 - Binding occupational exposure limits for carcinogens in the EU - necessary but not sufficient to reduce risk. AU - Cherrie, John W.. PY - 2019/7/1. Y1 - 2019/7/1. KW - Cancer. KW - Carcinogen. KW - Exposure. KW - Exposure limit. KW - Exposure limit value. KW - Letter. KW - Occupational cancer. KW - Occupational exposure. KW - Occupational exposure limit. KW - Work-related cancer. UR - http://www.scopus.com/inward/record.url?scp=85068990664&partnerID=8YFLogxK. U2 - 10.5271/sjweh.3836. DO - 10.5271/sjweh.3836. M3 - Article. C2 - 31256196. VL - 45. SP - 423. EP - 424. JO - Scandinavian Journal of Work, Environment and Health. JF - Scandinavian Journal of Work, Environment and Health. SN - 0355-3140. IS - 4. ER - ...
TY - JOUR. T1 - Advanced REACH tool. T2 - a Bayesian model for occupational exposure assessment. AU - McNally, Kevin. AU - Warren, Nicholas. AU - Fransman, Wouter. AU - Entink, Rinke Klein. AU - Schinkel, Jody. AU - Van Tongeren, Martie. AU - Cherrie, John W.. AU - Kromhout, Hans. AU - Schneider, Thomas. AU - Tielemans, Erik. PY - 2014. Y1 - 2014. N2 - This paper describes a Bayesian model for the assessment of inhalation exposures in an occupational setting; the methodology underpins a freely available web-based application for exposure assessment, the Advanced REACH Tool (ART). The ART is a higher tier exposure tool that combines disparate sources of information within a Bayesian statistical framework. The information is obtained from expert knowledge expressed in a calibrated mechanistic model of exposure assessment, data on interand intra-individual variability in exposures from the literature, and context-specific exposure measurements. The ART provides central estimates and credible ...
Federal Register: April 27, 2007 (Volume 72, Number 81)][Notices] [Page 21054-21055] From the Federal Register Online via GPO Access [wais.access.gpo.gov] [DOCID:fr27ap07-85] ----------------------------------------------------------------------- DEPARTMENT OF LABOR Occupational Safety and Health Administration [Docket No. OSHA-2007-0022] Standard on Occupational Exposure to Noise (Noise); Extension of the Office of Management and Budgets (OMB) Approval of Information Collection (Paperwork) Requirements AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Request for public comment. ----------------------------------------------------------------------- SUMMARY: OSHA solicits public comments concerning its proposal to extend OBM approval of the information collection requirements contained in its Noise Standard (29 CFR 1910.95). The information collection requirements specified in the Noise Standard protect employees from suffering material hearing impairment. DATES: ...
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Influence of childhood asthma and allergies on occupational exposure in early adulthood: a prospective cohort study Conference Paper ...
TY - JOUR. T1 - A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma. AU - Wang, Yuan Hung. AU - Yeh, Shauh Der. AU - Shen, Kun Hung. AU - Shen, Cheng Huang. AU - Juang, Guang Dar. AU - Hsu, Ling I.. AU - Chiou, Hung Yi. AU - Chen, Chien Jen. PY - 2009/11/15. Y1 - 2009/11/15. N2 - Cigarette smoking, arsenic and occupational exposures are well-known risk factors for the development of urothelial carcinoma (UC). Therefore, the aim of this study is to investigate whether the effect of cigarette smoking, alcohol consumption, arsenic and occupational exposures on risk of UC could be modified by genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase omega. A hospital-based case-control study consisted of 520 histologically confirmed UC cases, and 520 age- and gender-matched cancer-free controls were carried out from September 1998 to December 2007. Genotyping of CYP2E1, GSTO1 ...
The listed calls for evidence concerning occupational exposure limits have already taken place and have now been closed. These calls were held to allow parties concerned to comment and to help ECHAs Risk Assessment Committee in developing an opinion on scientific evaluation of occupational exposure limit(s).. The substances or chemical agents are listed in the table below together with information on the subject.. ...
The listed calls for evidence concerning occupational exposure limits have already taken place and have now been closed. These calls were held to allow parties concerned to comment and to help ECHAs Risk Assessment Committee in developing an opinion on scientific evaluation of occupational exposure limit(s).. The substances or chemical agents are listed in the table below together with information on the subject.. ...
The listed calls for evidence concerning occupational exposure limits have already taken place and have now been closed. These calls were held to allow parties concerned to comment and to help ECHAs Risk Assessment Committee in developing an opinion on scientific evaluation of occupational exposure limit(s).. The substances or chemical agents are listed in the table below together with information on the subject.. ...
Please follow this link to learn about the EU Strategy on Exposure to chemical agents.. Commission Directive 2009/161/EU of 17 December 2009 establishing a third list of indicative occupational exposure limit values in implementation of Council Directive 98/24/EC and amending Commission Directive 2000/39/EC.. Commission Directive 2006/15/EC of 7 February 2006 establishing a second list of indicative occupational exposure limit values in implementation of Council Directive 98/24/EC and amending Directives 91/322/EEC and 2000/39/EC. Commission Directive 2000/39/EC of 8 June 2000 establishing a first list of indicative occupational exposure limit values in implementation of Council Directive 98/24/EC. ...
The review of the Oil and Gas plant studies has allowed us to identify an opportunity to enhance the initial exposure information by recommending the next steps for industrial hygiene and occupational exposure information by recommending the next steps for industrial hygiene and occupational exposure assessment. A cumulative assessment should be performed that groups the chemical substances identified at Oil and Gas plant into two groups. Group 1 would be chemicals that exhibit classic dose response curves and are non-carcinogenic. The other group, group 2, would be identified carcinogens. Chemicals in Group 1 should be further assessed and subdivided into chemicals published TLVs and those without, and then grouped by systemic toxicology class to allow for the calculation of a cumulative exposure. Control banding methods can then be applied to estimate and assign an exposure hazard category.. Group 2 chemicals, the carcinogens, could be analysed and evaluated using method applied in Chen et ...
Occupational hygiene (United States: industrial hygiene (IH)) is the anticipation, recognition, evaluation, control and prevention of hazards from work that may result in injury, illness, or affect the well being of workers. These hazards or stressors are typically divided into the categories biological, chemical, physical, ergonomic and psychosocial.[1] The risk of a health effect from a given stressor is a function of the hazard multiplied by the exposure to the individual or group.[2] For chemicals, the hazard can be understood by the dose response profile most often based on toxicological studies or models. Occupational hygienists work closely with toxicologists (see Toxicology) for understanding chemical hazards, physicists (see Physics) for physical hazards, and physicians and microbiologists for biological hazards (see Microbiology Tropical medicine Infection) Environmental and occupational hygienists are considered experts in exposure science and exposure risk management. Depending on an ...
The study of the performance of a JEM comprises three main elements as described by Bouyer et al 18: (a) the ability of the JEM to evaluate accurately the exposure itself, (b) its statistical performance in terms of bias and power, (c) its ability to detect known associations between risk factors and disease. In our study, only point (c) can be directly studied to estimate the performance of the population specific JEM although the two other aspects may be considered indirectly. The pattern of relations between the probability of exposure and a decrease in FEV1 found in the French survey and evidence of known associations in two different populations (French survey and rural Dutch residents) are arguments in favour of the validity of the population specific JEM. The lowest κ values between self reported exposure and the Pp JEM were found in the groups in which the population specific JEM performed better than self reported exposure.. An argument in favour of the accurate exposure assessment of ...
The resurgence of tuberculosis in the United States within the past decade has prompted the health care community to develop tuberculosis elimination policies. However, recent outbreaks of tuberculosis have proved to be resistant to multiple antibiotics. Tuberculosis infections among health care workers is also rising. This increase in occupational exposures has prompted the examination of current exposure control measures. The occupational exposure to tuberculosis is prevented by the use of administrative policies, engineering controls and personal protective equipment. Each control measure has inherent strengths and weaknesses and when implemented through an exposure control plan the risk of occupational exposure can be reduced. Control techniques currently utilized may benefit from additional research and development. The research will not be squandered if tuberculosis is ultimately eliminated, as the knowledge gained may prove beneficial for exposure protection from future bio-hazardous aerosols.
A modification of the Nationwide Evaluation of X-Ray Trends (NEXT) survey procedure has been used to collect data on technique and exposure values for the A/P abdomen and A/P lumbosacral spine projection for a fixed patient size. Through the use of a sample set of patient radiographs and a phantom, technique factors and entrance skin exposure (ESE) are related to a radiograph of acceptable density. An analysis of 139 surveys demonstrates the wide range of techniques and exposures associated with each projection and suggests that ranges of typical techniques and exposure values can be defined ...
The Community indicative occupational exposure limit values are established as implementation of Council Directive 98/24/EC. In the Annex to Directive 2000/39/EC, the reference to phenol is deleted and the new limit values are included in this Directive. The Directive establishes values for a reference period of eight-hours time weighted average and also for a short term period of 15 minutes for 18 chemical agents. ...
Throughout the legal text: Council Directive 98/24/EC of 7 April 1998 on the protection of the health and safety of workers from the risks related to chemical agents at work. Recital 2 makes reference to: Council Directive 89/391/EEC of 12 June 1989 on the introduction of measures to encourage improvements in the safety and health of workers at work In relation to measurement techniques introduced by Article 17 of that Directive. Recital 3 makes reference to: Commission Decision 2014/113/EU of 3 March 2014 on setting up a Scientific Committee on Occupational Exposure Limits for Chemical Agents and repealing Decision 95/320/EC In relation to the Scientific Committee on Occupational Exposure Limits for Chemical Agents (SCOEL). Recital 14 makes reference to: (1) Commission Directive 91/322/EEC of 29 May 1991 on establishing indicative limit values by implementing Council Directive 80/1107/EEC on the protection of workers from the risks related to exposure to chemical, physical and biological agents ...
OBJECTIVES: It is plausible that neurodegenerative processes of aging might have a contributing role in the development of chronic effects of exposure to organic solvents. This study evaluated the risk for neuropsychological deficits among retired workers, relative to their histories of exposure to occupational solvents. METHODS: This cross sectional study evaluated retired male workers, 62-74 years of age, including 89 people with previous long-term occupational exposure to solvents (67 retired painters and 22 retired aerospace manufacturing workers), and 126 retired carpenters with relatively minimal previous exposure to solvents. Subjects completed a standardised neuropsychological evaluation and psychiatric interview, structured interviews for histories of occupational exposure and alcohol consumption, and questionnaires assessing neurological and depressive symptoms. RESULTS: By comparison with the carpenters, the painters on average reported greater cumulative alcohol consumption and had ...
Background: The aim was to investigate possible associations between glioma (an aggressive type of brain cancer) and occupational exposure to selected agents: combustion products (diesel and gasoline exhaust emissions, benzo(a)pyrene), dusts (animal dust, asbestos, crystalline silica, wood dust) and some other chemical agents (formaldehyde, oil mist, sulphur dioxide). Methods. The INTEROCC study included cases diagnosed with glioma during 2000-2004 in sub-regions of seven countries. Population controls, selected from various sampling frames in different centers, were frequency or individually matched to cases by sex, age and center. Face-to-face interviews with the subject or a proxy respondent were conducted by trained interviewers. Detailed information was collected on socio-economic and lifestyle characteristics, medical history and work history. Occupational exposure to the 10 selected agents was assessed by a job exposure matrix (JEM) which provides estimates of the probability and level of ...
Abstract Background The aim was to investigate possible associations between glioma (an aggressive type of brain cancer) and occupational exposure to selected agents: combustion products (diesel and gasoline exhaust emissions, benzo(a)pyrene), dusts (animal dust, asbestos, crystalline silica, wood dust) and some other chemical agents (formaldehyde, oil mist, sulphur dioxide). Methods The INTEROCC study included cases diagnosed with glioma during 2000-2004 in sub-regions of seven countries. Population controls, selected from various sampling frames in different centers, were frequency or individually matched to cases by sex, age and center. Face-to-face interviews with the subject or a proxy respondent were conducted by trained interviewers. Detailed information was collected on socio-economic and lifestyle characteristics, medical history and work history. Occupational exposure to the 10 selected agents was assessed by a job exposure matrix (JEM) which provides estimates of the probability and ...
Plain text: Objectives We aimed to update an asthmagen job exposure matrix (JEM) developed in the late 1990s. Main reasons were: the number of suspected and recognised asthmagens has since tripled; understanding of the aetiological role of irritants in asthma and methodological insights in application of JEMs have emerged in the period. Methods For each agent of the new occupational asthma-specific JEM (OAsJEM), a working group of three experts out of eight evaluated exposure for each International Standard Classification of Occupations, 1988 (ISCO-88) job code into three categories: high (high probability of exposure and moderate-to-high intensity), medium (low-to-moderate probability or low intensity) and unexposed. Within a working group, experts evaluated exposures independently from each other. If expert assessments were inconsistent the final decision was taken by consensus. Specificity was favoured over sensitivity, that is, jobs were classified with high exposure only if the ...
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The aims of this study were to produce a population-based estimate of the prevalence of work-related exposure to lead and its compounds, to identify the main circumstances of exposures, and to collect information on the use of workplace control measures designed to decrease those exposures. Data came from the Australian Workplace Exposures Study, a nationwide telephone survey which investigated the current prevalence and circumstances of work-related exposure to 38 known or suspected carcinogens, including lead, among Australian workers aged 18-65 years. Using the web-based tool, OccIDEAS, semi-quantitative information was collected about exposures in the current job held by the respondent. Questions were addressed primarily at tasks undertaken rather than about self-reported exposures. A total of 307 (6.1%) of the 4993 included respondents were identified as probably being exposed to lead in the course of their work. Of these, almost all (96%) were male; about half worked in trades and ...
This companion document to the ACGIH® Threshold Limit Values and Biological Exposure Indices book serves as a readily accessible reference for comparison of the most recently published values.
This companion document to the ACGIH® Threshold Limit Values and Biological Exposure Indices book serves as a readily accessible reference for comparison of the most recently published values.
Objectives Preeclampsia is a leading cause of maternal and perinatal morbidity. Work-related factors may influence the occurrence of this disorder. This case-control study estimated the associations between work-related physical and psychosocial factors and the risk of preeclampsia and gestational hypertension.. Methods The eligible women consisted of a random sample of the women who delivered a singleton live birth in 1997-1999 in six regions of Quebec and worked during pregnancy. Cases of preeclampsia (N=102) and gestational hypertension (N=99) were compared with normotensive controls (N=4381). Information on occupational exposures at the onset of pregnancy was collected during phone interviews a few weeks after delivery. Detailed information was obtained on work schedule, postures, physical exertion, work organization, noise, vibration, and extreme temperature. Adjusted odds ratios (aOR) were estimated through polytomous logistic regression.. Results Women standing daily at least 1 hour ...
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Pacemakers (PM) or implantable cardioverter-defibrillators (ICD) can be disturbed by magnetic field exposure at work. Based on experimental exposure of volunteers and the experience from in situ case studies, the authors present an approach to evaluate word safety and the workers fitness in such situations.. For the PMs situations, there are data allowing to make a decision in the majority of the cases. In the case of ICD, an adapted study is necessary. A protocol for risk evaluation was finalized, where the worker may move within the framework of his professional activity. These measures are made in his presence, while simultaneously monitoring the operation of the device.. Three practical realized cases of measurements are presented, with their difficulties of realization and their results.. Conclusion: A decision about the workers fitness can then be taken on the basis of this information. This approach can be extended to the other medical implants and with electromagnetic spectrum ...
Brian C. Lee (bclee at access2.digex.net) writes: , A liver carcinoma is considered benign? What kind of cell type was it? , 25-fold sounds pretty low. Was there any human exposure data to show , a non-carcinogenic exposure level? Sorry, I was mistaken in my initial post. The 75 ppm LOEL in males rats was for adenomas; carcinomas and adenomas were elevated at 375 ppm. The current occupational exposure level is 10 ppm. The proposal was to reduce that to 3 ppm in light of the new data, but that seems inadequate given the LOEL for liver adenoma in male rats. , : I am currently reviewing information concerning a proposed occupational , : exposure limit for an industrial chemical. The substance is a , : non-genotoxic carcinogen, which has been tested in both mouse and rat , : chronic/onco studies. In males of both species, statistically significant , : increases in liver adenomas/carcinomas were observed at exposure levels of , : 75 ppm. The company that manufactures the substance is proposing a TWA ...
Inspection guidelines: The Compliance Officer should verify that the training is provided at the time of initial employment and at least annually thereafter as well as whenever a change in an employees responsibilities, procedures, or work situation is such that an employees occupational exposure is affected. At the time of initial assignment to tasks where occupational exposure may take place means that employees must be trained prior to being placed in positions where occupational exposure may occur. The annual retraining for these employees must be provided within one year of their original training. This refresher training must cover topics listed in the standard to the extent needed and must emphasize new information or procedures. It does need to be an exact repetition of the previous annual training ...
Healthcare personnel handling cytostatic antineoplastic agents may be exposed to these drugs. Exposure may occur through inhalation, skin contact, skin absorption, ingestion, or injection during preparation, administration, and disposal. Since the late 70s, occupational exposure to these drugs has been recognized as a potential health hazard.. Since then, several countries have published guidelines and recommendations with the objective to improve operating procedures and safety workplace, and keep exposure levels as low as possible. As a consequence, operating procedures have been improved,biological and environmental monitoring have been used to assess contamination and exposure levels, and a lot of analytical methods have been developed and validated.. In general, the strategy used to prevent or minimize occupational exposure applies a combination of interventions, such as engineering controls, administrative and work practice controls, and personal protective equipment.. In Italy, the ...
We investigated occupational exposure to diesel motor exhaust (DME) and the risk of lung cancer by histological subtype among men, using elemental carbon (EC) as a marker of DME exposure. 993 cases and 2359 controls frequency-matched on age and year of study inclusion were analyzed by unconditional logistic regression in this Swedish case-control study. Work and smoking histories were collected by a questionnaire and telephone interviews. DME was assessed by a job-exposure matrix. We adjusted for age, year of study inclusion, smoking, occupational exposure to asbestos and combustion products (other than motor exhaust), residential exposure to radon and exposure to air pollution from road traffic. The OR for lung cancer for ever vs. never exposure to DME was 1.15 (95% CI 0.94-1.41). The risk was higher for squamous and large cell, anaplastic or mixed cell carcinoma than for alveolar cell cancer, adenocarcinoma and small cell carcinoma. The OR in the highest quartile of exposure duration (,=34 ...
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Exposure-response (ER) modeling for fixed-dose combinations (FDC) has previously been found to have an inflated false positive rate (FP), i.e., observing a significant effect of FDC components when no true effect exists. Longitudinal exposure-response (LER) analysis utilizes the time course of the data and is valid for several clinical endpoints for FDCs. The aim of the study was to investigate if LER is applicable for the validation of FDCs by demonstrating the contribution of each component to the overall effect without inflation of FP rates. FP and FN rates associated with ER and LER analysis were investigated using stochastic simulation and estimation. Four hundred thirty-two scenarios with varying numbers of patients, duration, sampling frequency, dose distribution, design, and drug activity were analyzed using a range of linear, log-linear, and non-linear models to asses FP and FN rates. Lastly, the impact of the clinical trial parameters was investigated. LER analyses provided ...
Buy Biological Effects of Low Level Exposures to Chemicals and Radiation (9780873716659): NHBS - Edited By: EJ Calabrese, Lewis Publishers
Workplace exposures can also affect the health of a pregnancy. Some chemical exposures might be riskier for a fetus than its mother, due to its rapid development and smaller relative size. For most chemicals, we dont have good information on what levels of exposure might harm a fetus. Occupational exposure limits were intended to protect workers, and cannot necessarily be applied to a fetus ...
International Trade Fair and Congress for the topics: Safety, Security and Health at work, 26 - 29 October 2021, Düsseldorf, Germany
The case-control study presented in this issue of Epidemiology by Cassidy et al1 provides striking evidence of an association between occupational exposure to crystalline silica and lung cancer. The study not only demonstrated an overall positive association, but also very strong evidence for an exposure-response relationship. These findings are not themselves very surprising or novel given that similar findings have been reported in numerous previous studies. What makes these findings most remarkable is that they come from a population-based case-control study. This study design has rarely been capable of demonstrating convincing evidence for associations for exposures to occupational carcinogens due to low power and poor exposure classification stemming from their reliance on self-reported exposures. These studies have been of particularly limited use in demonstrating exposure-response relationships. In large part the success of this study is due to the unusually detailed questionnaires on ...
When assessing occupational exposures, repeated measurements are in most cases required. Repeated measurements are more resource intensive than a single measurement, so careful planning of the measurement strategy is necessary to assure that resources are spent wisely. The optimal strategy depends on the objectives of the measurements. Here, two different models of random effects analysis of variance (ANOVA) are proposed for the optimization of measurement strategies by the minimization of the variance of the estimated log-transformed arithmetic mean value of a worker group, i.e. the strategies are optimized for precise estimation of that value. The first model is a one-way random effects ANOVA model. For that model it is shown that the best precision in the estimated mean value is always obtained by including as many workers as possible in the sample while restricting the number of replicates to two or at most three regardless of the size of the variance components. The second model introduces ...
Today, while working at Home Depot, a customer tried to engage me in a conversation about which gardening tool would hypothetically be the best to kill his wife with. FML
Today, while working at a bank, I helped a customer who was making a large withdrawal. After I counted out his money, I asked Do you want the strap on? After a moment of awkward silence, as I realized how that came out, he smiled and said, No thanks, I dont need one. and winked. Great. FML
While working with staphylococcus variants a number of culture-plates were set aside on the laboratory bench and examined from time to time....
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Retrospective exposure assessment using Bayesian methods.: This paper presents the application of a Bayesian framework for retrospective exposure assessment of
Introduction: To date, occupational exposure assessment of electromagnetic fields (EMF) has relied on occupation-based measurements and exposure estimates. However, misclassification due to between-worker variability remains an unsolved challenge. A source-based approach, supported by detailed subject data on determinants of exposure, may allow for a more individualized exposure assessment. Detailed information on the use of occupational sources of exposure to EMF was collected as part of the INTERPHONE-INTEROCC study. To support a source-based exposure assessment effort within this study, this work aimed to construct a measurement database for the occupational sources of EMF exposure identified, assembling available measurements from the scientific literature. Methods: First, a comprehensive literature search was performed for published and unpublished documents containing exposure measurements for the EMF sources identified, a priori as well as from answers of study subjects. Then, the ...
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Hydrocarbon exposure has been shown to play an important role in the development of renal dysfunction in several occupational settings. In this study, renal screening was performed in a group of paint sprayers with exposure to hydrocarbon-based paints, recruited from a car manufacturing plant where personal protective equipment was widely used. The hydrocarbon exposure scores and various markers of renal injury were compared between these subjects and a group of paint sprayers from a previous study who did not use personal protective equipment regularly. Cumulative hydrocarbon exposure scores were calculated from a validated questionnaire. Serum creatinine, urinary total protein, albumin, transferrin, retinol-binding protein, and N-acetylglucosaminidase were evaluated, Both groups experienced heavy hydrocarbon exposure but sprayers who regularly used personal protective equipment had significantly reduced exposure scores due to improved skin and respiratory protection. A significant number of ...
AIMS: This study investigates whether work-related respiratory symptoms and acute falls in forced expiratory volume in 1 second (FEV1), previously observed in current welders, are related to measured workplace exposures to total fume and metals. METHODS: At four work sites in New Zealand, changes in pulmonary function (and reported respiratory symptoms) were recorded in 49 welding workers (and 26 non-welders) exposed to welding fume. We also determined the personal breathing zone levels of total fume and various metals. RESULTS: Work-related respiratory symptoms were reported by 26.5% of welders and 11.5% of non-welders. These symptoms were related significantly to their personal breathing zone nickel exposure--with an adjusted odds ratio (OR) and 95% confidence interval [CI] of the high exposure group (compared to a low exposure group of 7.0 [1.3-36.6]). There were non-significant associations with total fume exposure (OR = 2.6, 95% CI 0.6-12.2), and exposure index of greater than 10 years ...
Occupational exposure limit monograph for Fingolimod. Affordable occupational exposure limits (OEL) for pharmaceuticals with instant download.
The risk for occupational exposure to HIV has been well characterized in the developed world, but limited information is available about this transmission risk in resource-constrained settings facing the largest burden of HIV infection. In addition, the feasibility and utilization of post-exposure prophylaxis (PEP) programs in these settings are unclear. Therefore, we examined the rate and characteristics of occupational exposure to HIV and the utilization of PEP among health care workers (HCW) in a large, urban government teaching hospital in Pune, India. Demographic and clinical data on occupational exposures and their management were prospectively collected from January 2003-December 2005. US Centers for Diseases Control guidelines were utilized to define risk exposures, for which PEP was recommended. Incidence rates of reported exposures and trends in PEP utilization were examined using logistic regression. Of 1955 HCW, 557 exposures were reported by 484 HCW with an incidence of 9.5 exposures per
Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (P-interaction ,= .001), rs11892031 (UGT1A, P-interaction = .01), and rs798766 (TMEM129-TACC3-FGFR3, P-interaction = .03). There was limited evidence for multiplicative interactions. When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P-interaction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression. All statistical tests were two-sided. The interaction ...
Loi sur la santé et la sécurité au travail. R.R.O. 1990, REGULATION 833. CONTROL OF EXPOSURE TO BIOLOGICAL OR CHEMICAL AGENTS. Historical version for the period July 1, 2010 to November 4, 2010.. Last amendment: O. Reg. 491/09.. This Regulation is made in English only.. 1. In this Regulation,. ACGIH means the American Conference of Governmental Industrial Hygienists; ACGIH Table means the table entitled Adopted Values shown at pages 10 to 61 of the publication entitled 2009 Threshold Limit Values and Biological Exposure Indices published by ACGIH and identified by International Standard Book Number 978-1-882417-95-7; C or ceiling limit means the maximum airborne concentration of a biological or chemical agent to which a worker may be exposed at any time;. chemical agent includes a chemical substance;. exposure means exposure by inhalation, ingestion, skin absorption or skin contact;. Ontario Table means Table 1 to this Regulation;. STEL or short-term exposure limit means ...
The National Institute for Occupational Safety and Health (NIOSH) recently developed a process to apply the occupational exposure banding process to a broad spectrum of occupational settings. These bands are assigned based on a chemicals potency and the negative health outcomes associated with exposure to the chemical. The output of this process is an occupational exposure band, which corresponds to a range of exposure concentrations that is expected to be protective to worker health. The new NIOSH occupational exposure banding process uses available, but often limited, toxicological data to determine a potential range of chemical exposure levels that can be used as targets for exposure controls to reduce risk among workers. Comments are being sought from individuals including scientists and representatives from various government agencies, industry, labor, and other stakeholders, and also the public, specifically regarding any errors of fact, unsubstantiated claims, evidence of careless ...
Organic dust consists of particles with a biological origin. Airborne levels of bacteria, fungi, endotoxins, and glucans have been investigated in epidemiological studies of mucous membrane irritation, inflammation, and airway obstruction. Organic dust can be measured by gravimetry of filter samples. Microorganisms can be quantified by culture, microscopic, and DNA-based methods. Culture methods underestimate microbial exposure and have poor precision. However, high sensitivity and identification of species that indicate fungal contamination have advantages in indoor air studies. Microscopic and DNA-based methods quantify microorganisms independent of cultivability. Specific organisms can even be quantified with molecular techniques. Quantification of specific organic dust components is preferred to dust levels. However, no occupational exposure limits exist for specific agents, although criteria for endotoxin and fungal spores have been proposed. In exposure assessments of microbial agents, ...
This thesis focuses on exacerbating chemicals risk in workplaces under the background of rapid industrialization in developing countries. The overall aim is to investigate the development of regulatory tools which aim at minimizing the health risks from chemical substances in the workplace. The contents of the thesis are divided into three sections: the profile of occupational diseases in China (paper I), occupational exposure limits (paper II and III), and comparison between chemicals regulat ions in Europe and China (paper IV).. Paper I presents an analysis of the development of occupational diseases in China between 2000 and 2010. The number of recorded cases of occupational diseases increased rapidly in China during this period and the majority of cases were attributable to dust and other chemicals exposures. Difficulties in diagnosis and inefficient surveillance are major impediments to the proper identification and mitigation of occupational diseases. Migrant workers are extremely ...
Author(s): Omidakhsh, Negar; Bunin, Greta R; Ganguly, Arupa; Ritz, Beate; Kennedy, Nola; von Ehrenstein, Ondine S; Krause, Niklas; Heck, Julia E | Abstract: OBJECTIVES:We examined associations between parental occupational chemical exposures up to 10 years before conception and the risk of sporadic retinoblastoma among offspring. METHODS:In our multicentre study on non-familial retinoblastoma, parents of 187 unilateral and 95 bilateral cases and 155 friend controls were interviewed by telephone. Exposure information was collected retroactively through a detailed occupational questionnaire that asked fathers to report every job held in the 10 years before conception, and mothers 1 month before and during the index pregnancy. An industrial hygienist reviewed all occupational data and assigned an overall exposure score to each job indicating the presence of nine hazardous agents. RESULTS:We estimated elevated ORs for unilateral and bilateral retinoblastoma among offspring of fathers who were exposed to
First responders and military personnel experience rates of post-traumatic stress disorder (PTSD) far in excess of the general population. Although exposure to acute traumatic events plays a role in the genesis of these disorders, in this review, we present an argument that the occupational and environmental conditions where these workers operate are also likely contributors. First responders and military personnel face occupational exposures that have been associated with altered immune and inflammatory activity. In turn, these physiological responses are linked to altered moods and feelings of well-being which may provide priming conditions that compromise individual resilience, and increase the risk of PTSD and depression when subsequently exposed to acute traumatic events. These exposures include heat, smoke, and sleep restriction, and physical injury often alongside heavy physical exertion. Provided the stimulus is sufficient, these exposures have been linked to inflammatory activity and
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Benzene is a known leukemogen and may cause lymphoma as well, but its ability to , cause these conditions below 10 parts per million (ppm) in air are unclear. It is currently regulated in the United States at 1 ppm as an 8-hour time-weighted average and at a 5 ppm short-term exposure level for 15 minutes. There is a critical need to assess risks related to benzene exposure under 10 ppm because it is widely used industrially and a ubiquitous contaminant in the environment.. The National Cancer Institute (NCI) and the Chinese Academy of Preventive Medicine (CAPM), whose name was recently changed to the China Center for Disease Control (CDC) previously established a cohort of 75,000 workers exposed to benzene in 12 cities in China and 35,000 unexposed comparison workers, to investigate the relationship between benzene exposure and cancer risk, from 1972 to 1987. We followed up each worker using factory records and reported results suggesting that benzene exposure under 10 ppm may be associated with ...
Adjusting occupational exposure limits for extended work shifts using OSHA regulations for lead and noise or via the brief and scala model
A historical cohort of service station attendants is underway. It is aimed at evaluating possible excess cancer risk relation to exposure intensity. In this paper we discuss the feasibility of a retrospective exposure assessment by evaluating the association between indicators of workload and the exposure intensity to some aromatic hydrocarbons...
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Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring ...
ILO: International Labour Organization - The International Labour Organization is the UN specialized agency which seeks the promotion of social justice and internationally recognized human and labour rights
Objectives: Setting and implementing occupational exposure limits (OELs) is one of the measures taken to protect workers from adverse effects of hazardous chemicals. The EU Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) introduced an additional kind...
As of 4 May 2018, organisations are to observe the revised occupational exposure limits (OELs) for 2495 substances. A Decree adopted on 13 February 2018 sets out maximum allowable concentrations (MACs) for 2495 harmful substances in the air of working zone.The adopted revised OELs are compulsory for all types of organisations regardless of ownership and corporate structure.The
was provided a list of 66 chemicals used by FIS personnel in their laboratory work. The primary sources of information used to evaluate carcinogenicity potential was to identify the chemicals that have already been evaluated and classified by government and non-government agencies, such as Canadian Centre for Occupational Health and Safety (CCOHS), the International Agency for Research on Cancer (IARC) monographs, the National Toxicology Programs Report on Carcinogens (NTP RoC), European Commissions Institute for Health and Consumer Protection (IHCP), California Environmental Protection Agency - Proposition 65: List of Chemicals Known to Cause Cancer (CalEPA Prop 65), American Conference of Governmental Industrial Hygienists - Threshold Limit Values for Chemical Substances and Physical Agents & Biological Exposure Indices (ACGIH, 2009), and Agency for Toxic Substances & Disease Registry (ATSDR). If a chemical was not listed in any of these databases, further searches of publicly available ...
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Keeping up with Occupational Exposure Limits can be tough - especially if your organization is expanding into new geographies. Learn how you can simplify OEL management with a centralized system.
Documentation of posture measurement costs is rare and cost models that do exist are generally naïve. This paper provides a comprehensive cost model for biomechanical exposure assessment in occupational studies, documents the monetary costs of three exposure assessment methods for different stakeholders in data collection, and uses simulations to evaluate the relative importance of cost components. Trunk and shoulder posture variables were assessed for 27 aircraft baggage handlers for 3 full shifts each using three methods typical to ergonomic studies: self-report via questionnaire, observation via video film, and full-shift inclinometer registration. The cost model accounted for expenses related to meetings to plan the study, administration, recruitment, equipment, training of data collectors, travel, and onsite data collection. Sensitivity analyses were conducted using simulated study parameters and cost components to investigate the impact on total study cost. Inclinometry was the most expensive
Lessening the risk of occupational pesticide exposure in agriculture is the purpose of EPAs Agricultural Worker Protection Standard. Now, EPA is proposing to amend its 1992 regulation so that almost 2 million workers can benefit from annual pesticide safety training that will include how to better protect themselves from pesticide exposure in the workplace and from bringing pesticides home on their clothes, exposing their families to chemicals. The proposal also includes updated personal protective equipment standards for pesticide handlers; a first-time ever minimum age requirement for pesticide handlers and some workers; improvements in the notification of pesticide treated areas; and access to information on pesticide application, the pesticide label, and safety data for farmworkers and their advocates.. ...
We studied the mortality from lung and pleural cancers in a cohort of 62,937 male workers employed for at least 1 year in the pulp and paper industry in 13 countries during 1945 to 1996. Mill departments were classified according to probability and level of exposure to asbestos on the basis of available dust measurements and mill-specific information on exposure circumstances. Thirty-six percent of workers were classified as ever exposed to asbestos. Standardized mortality ratios of lung cancer were 0.99 (95% confidence interval [CI], 0.90 to 1.08) among unexposed and 1.00 (95% CI, 0.90 to 1.11) among ever exposed workers. The number of pleural cancer deaths among unexposed workers was 10; that among exposed workers was 14, most of which occurred among maintenance workers. In internal analyses, a trend in mortality from either neoplasm was suggested for estimated cumulative exposure to asbestos, weighted for the individual probability of exposure within the department and for duration of ...
The current pooled analyses of data from phase II trials in advanced melanoma represent the first quantification of exposure-response relationships for ipilimumab efficacy and safety endpoints in any tumor type. Specifically, the purpose of this study was to determine if there is an association between pharmacokinetics (exposure) and key clinical outcomes with ipilimumab, and to determine baseline patient characteristics that may impact these relationships. While there are 2 completed phase III clinical trials of ipilimumab in patients with advanced melanoma (4, 5), data from the 4 completed phase II studies included herein provide the largest dataset across a consistent patient population and treatment regimen, and provide a range of evaluated ipilimumab doses. Exposure-response analyses for ipilimumab at 10 mg/kg in combination with dacarbazine in patients with previously untreated advanced melanoma (5) are the subject of separate publications.. One of the objectives of the exposure-response ...
Author: Azizova T.B.. Reference: Candidate of medical sciences, 1999, Moscow. Keywords: neurology, personnel aged 35-45, syndrome. Abstract: The work presents a comprehensive view on the newest, by then, results of research made on the effect of ionizing radiation on the nervous system. Atomic neurology is a relatively new field of science, hence, this article has a value of being one of the earliest comprehensive works on the topic. The work describes details of syndromes detected in the liquidators of Chernobyl. Epidemiological data are shown.. URL:http://medical-diss.com/medicina/sostoyanie-nervnoy-sistemy-u-lits-podvergshihsya-hronicheskomu-professionalnomu-vozdeystviyu-ioniziruyuschego-izlucheniya. ...
The association of asthma with occupational exposures was studied in 14,151 adults, aged 25-59 years, from the general population of the 1975 French Pollution Atmosphérique et Affections Respiratoires Chroniques (PAARC) Survey. Associations of asthma with specific jobs, such as personal care workers, waiters, and stock clerks, were observed, with age-, sex-, and smoking-adjusted odds ratios between 1.5 and 1.7. Exposures to 18 asthmagenic agents (low and high molecular weight and mixed environment) were estimated by an asthma-specific job exposure matrix. Risks associated with asthma increased when subjects with imprecise estimates of exposure were excluded. Risks increased further with increasing specificity of the definition of asthma when considering jobs or specific agents, such as industrial cleaning agents, latex, flour, highly reactive chemicals, and textiles. For example, for industrial cleaning agents, odds ratios increased from 1.55 (95% confidence interval (CI): 1.08, 2.23) for ...
Maria Lorenzi successfully defended her M.Sc. project entitled Analysis of Occupational Cohort Data Using Exposure as a Continuous Time-dependent Variable on 3 August 2005.. In occupational cohort studies, a group of workers is followed over time, and disease and work history information are collected for each individual in order to determine whether exposure to a particular substance is linked to differences in mortality or disease incidence rates. These studies are typically analyzed by treating cumulative exposure as a categorical variable and then comparing disease or mortality rates between different exposure groups. A main shortfall of such analyses is a heavy dependence on the choice of these exposure categories, as certain choices may mask or exaggerate important features of the dose-response curve. In this project, an extension to the Cox proportional hazards model is used to treat cumulative exposure as a continuous variable and model the dose-response curve nonparametrically for a ...
Maria Lorenzi successfully defended her M.Sc. project entitled Analysis of Occupational Cohort Data Using Exposure as a Continuous Time-dependent Variable on 3 August 2005.. In occupational cohort studies, a group of workers is followed over time, and disease and work history information are collected for each individual in order to determine whether exposure to a particular substance is linked to differences in mortality or disease incidence rates. These studies are typically analyzed by treating cumulative exposure as a categorical variable and then comparing disease or mortality rates between different exposure groups. A main shortfall of such analyses is a heavy dependence on the choice of these exposure categories, as certain choices may mask or exaggerate important features of the dose-response curve. In this project, an extension to the Cox proportional hazards model is used to treat cumulative exposure as a continuous variable and model the dose-response curve nonparametrically for a ...
We are reviewing the Workplace exposure standards for airborne contaminants to ensure they are based on the highest quality, contemporary evidence and supported by a rigorous, scientific approach.. The draft evaluation reports for each chemical will be available for public comment. Chemicals will be released alphabetically throughout 2019 and 2020. Public comment will be open for each release for a period of four weeks on Engage.. The chemical release groups and the anticipated dates for opening public comment are outlined below. Please note these dates are indicative only. For the latest information please continue to visit Engage.. ...
(PRWEB) June 19, 2014 -- The Mesothelioma Compensation Center frequently gets phone calls from manufacturing workers who have no clue how, or where they could
Kouvonen, AM, Väänänen, A, Woods, SA, Heponiemi, T, Koskinen, A and Toppinen-Tanner, S (2008) Sense of coherence and diabetes: a prospective occupational cohort study ...
Certain occupational exposures are known to increase cancer risk. These include hydrocarbons, heavy metals, mustard gas and chemicals used in leather, rubber and woodworking industries.
The list includes chemical substances and physical agents to be considered for Threshold Limit Values and Biological Exposure Indices.
Exposure assessment is also used to support epidemiological studies, toxicity assessments, and medical monitoring.. Exposure assessment incorporates information on the physical setting, potentially exposed populations, potential exposure pathways (generally inhalation, dermal and/or ingestion intake) and exposure concentrations to estimate intake or dose of the chemical or agent.. Exposure depends on various characteristics of the agent, such as particle shape or fiber size (for inhalation), form of radiation (for example) or chemical species, chemical composition, environmental fate and transport of the chemical, bioavailability, human behavior and use/misuse, whether natural barriers or personal protective equipment prevent actual exposure, and whether the substance is transformed (or adsorbed, retained, metabolized, or excreted) within the body.. The Challenges of Exposure Assessment. Characterizing historical occupational, environmental, or consumer product exposures is especially ...