TY - JOUR. T1 - Vesicular nucleotide transporter (VNUT). T2 - appearance of an actress on the stage of purinergic signaling. AU - Moriyama, Yoshinori. AU - Hiasa, Miki. AU - Sakamoto, Shohei. AU - Omote, Hiroshi. AU - Nomura, Masatoshi. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Vesicular storage of ATP is one of the processes initiating purinergic chemical transmission. Although an active transport mechanism was postulated to be involved in the processes, a transporter(s) responsible for the vesicular storage of ATP remained unidentified for some time. In 2008, SLC17A9, the last identified member of the solute carrier 17 type I inorganic phosphate transporter family, was found to encode the vesicular nucleotide transporter (VNUT) that is responsible for the vesicular storage of ATP. VNUT transports various nucleotides in a membrane potential-dependent fashion and is expressed in the various ATP-secreting cells. Mice with knockout of the VNUT gene lose vesicular storage and release of ATP from neurons ...
Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation.
Lenti ORF particles, SLC39A7 (mGFP-tagged) - Human solute carrier family 39 (zinc transporter), member 7 (SLC39A7), transcript variant 1, 200 uL, |10^7 TU/mL, 200 µl.
Recombinant Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Protein (GST tag). Spezies: Human. Quelle: Wheat germ. Jetzt Produkt ABIN1320502 bestellen.
Increased O(2) metabolism resulting in chronic hypoxia is common in models of endstage renal disease. Mitochondrial uncoupling increases O(2) consumption but the ensuing reduction in mitochondrial membrane potential may limit excessive oxidative stress. The present study addressed the hypothesis that mitochondrial uncoupling regulates mitochondria function and oxidative stress in the diabetic kidney. Isolated mitochondria from kidney cortex of control and streptozotocin-induced diabetic rats were studied before and after siRNA knockdown of uncoupling protein-2 (UCP-2). Diabetes resulted in increased UCP-2 protein expression and UCP-2-mediated uncoupling, but normal mitochondria membrane potential. This uncoupling was inhibited by GDP, which also increased the membrane potential. siRNA reduced UCP-2 protein expression in controls and diabetics (-30-50%), but paradoxically further increased uncoupling and markedly reduced the membrane potential. This siRNA mediated uncoupling was unaffected by GDP ...
The delivery of nucleotide sugar substrates into the endomembrane for processes such as cell wall biosynthesis and protein glycosylation is critical for plant growth and development. Although plant genomes encode large families of putative nucleotide sugar transporters (NSTs) that deliver the diverse array of nucleotide sugars found in plants, few have been characterized. Recently, we developed a yeast proteoliposome transporter assay coupled to LC-MS, specifically designed to characterize NSTs. ...
SLC39A3 - SLC39A3 (untagged)-Human solute carrier family 39 (zinc transporter), member 3 (SLC39A3), transcript variant 1 available for purchase from OriGene - Your Gene Company.
SLC35C1 - SLC35C1 (untagged)-Human solute carrier family 35, member C1 (SLC35C1), transcript variant 2 available for purchase from OriGene - Your Gene Company.
SLC22A3 antibody for detecting human solute carrier family 22 member 3. Validated on up to 12 cell lysates for western blotting. Try a trial size today.
The human solute carrier 26 (SLC26) family of anion transporters consists of ten members that are found in various organs in the body including the stomach, intestine, kidney, thyroid and ear where they transport anions including bicarbonate, chloride and sulfate, typically in an exchange mode. Mutations in these genes cause a plethora of diseases such as diastrophic dysplasia affecting sulfate uptake into chondrocytes (SLC26A2), congenital chloride-losing diarrhoea (SLC26A3) affecting chloride secretion in the intestine and Pendreds syndrome (SLC26A4) resulting in hearing loss. To understand how these mutations affect the structures of the SLC26 membrane proteins and their ability to function properly, 12 human disease-causing mutants from SLC26A2, SLC26A3 and SLC26A4 were introduced into the equivalent sites of the sulfate transporter anti-sigma factor antagonist (STAS) domain of a bacterial homologue SLC26 protein DauA (YchM). Biophysical analyses including size-exclusion chromatography, ...
This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014 ...
Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner membrane of mitochondria. They are found in all mammals and in plants. They belong to the family of anion mitochondrial carriers including adenine nucleotide transporters. The term uncoupling protein was originally used …
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I had high BP, controlled by meds, before I got pregnant. When I was 26 wks; I showed some protein in my 24 hr urine test, a little swelling of my feet, and uncontrolled BP. I was put on strict bedrest and my BP med dose was increased and they added a second medication. Since then, my BP has come down to normal, and the protein in my urine decreased. Two weeks ago I did anohter 24 hr urine and my protein was up to 1000. My OB said she expected an increase, but not to worry unless it jumps up quickly. I am really scared!! My BP is still normal and I am not showing any swelling. Over the past couple of weeks I have not been an angel when it comes to strict bedrest. Did I do this to myself? Am I harming my baby? Should I ask my OB to do something else? I have two NSTs a week, and I see the OB once a week. Previous u/s show the baby is fine. I was reading other posts, and I dont want to have seizures, or lose my baby. I am really scared! Is there anything I can do, or does it sound like the doctors ...
Transport of activated nucleotide-sugars into the Golgi is critical for proper glycosylation and mutations in these transporters cause a group of rare genetic disorders termed congenital disorders of glycosylation. We performed exome sequencing on an individual with a profound neurological presentation and identified rare compound heterozygous mutations, p.Thr156Arg and p.Glu196Lys, in the CMP-sialic acid transporter, SLC35A1. Patient primary fibroblasts and serum showed a considerable decrease in the amount of N- and O-glycans terminating in sialic acid. Direct measurement of CMP-sialic acid transport into the Golgi showed a substantial decrease in overall rate of transport. Here we report the identification of the third patient with CMP-sialic acid transporter deficiency, who presented with severe neurological phenotype, but without hematological abnormalities. ...
Shop UDP-galactose transporter ELISA Kit, Recombinant Protein and UDP-galactose transporter Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Im now 34 weeks into my 2nd pregnancy after having HELLP almost 7 years ago and ending up in acute kidney failure at that time. I too have chronic hypertension (though it is controlled on a very low dose of BP meds now) and chronic kidney disease. I got the ok after allowing my kidneys to recover as much as possible and getting the creatinine below 2.0 (normal is below 1.0). So far this pregnancy has been completely normal and my BP and kidneys are stable. My BP has stayed below 120/80 for the last few months. Im being monitored very closely with several ultrasounds and NSTs and blood testing ...
NPI Number: 1003964594. Healthcare provider: DR. LYNETTE S JATTAN-CUNNINGHAM M.D.. Practice location address: 1277B WELLBROOK CIR NE CONYERS, GA, 30012-3873
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Eur J Hum Genet 23 (6):753-60.. 34. Schlessinger A, Sun NN, Colas C, Pajor AM (2014) Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter, NaDC3. J Biol Chem 289 (24):16998-17008.. 33. Yachdav G, Kloppmann E, Kajan L, Hecht M, Goldberg T, Hamp T, Schafferhans A, Roos M, Bernhofer M, Richter L, Ashkenazy H, Punta M, Schlessinger A, Bromberg Y, Schneider R, Vriend G, Sander C, Ben-Tal N, Rost B (2014) PredictProtein - open online prediction of protein structure and function. Nucleic Acids Res 42 (Web Server issue):W337-43.. 32. Feiglin A, Ashkenazi S, Schlessinger A, Rost B, Ofran Y (2014) Co-expression and co-localization of hub proteins and their partners are encoded in protein sequence. Mol Biosyst 210 (4):787-94.. 31. Schlessinger A. (2014) Characterizing the structure, function, and evolution of human Solute Carrier (SLC) transporters using computational approaches. In: Membrane Transport Mechanism: 3D Structure and Beyond (Springer Series in ...
Approximately 80% of secreted and membrane proteins (40% of all proteins) of eukaryotes become covalently linked to sugars in the lumen of the Golgi apparatus, a cellular organelle that is part of the secretory system of all eukaryotes. The sugar donors are mostly nucleoside diphosphate sugars (nucl …
The subcellular localization studies of the URGT family indicated that they are located in the Golgi apparatus, which underlines their function as Golgi resident NSTs. All six URGTs are expressed ubiquitously throughout plant development, with URGT1 showing the highest expression levels and URGT2 preferentially expressed during seed development. To characterize the function of URGT1 and URGT2 in planta, we identified loss-of-function mutants and generated plants overexpressing URGT1 and URGT2.. The urgt1 mutants and plants overexpressing URGT1 confirmed its role as a UDP-Gal transporter in vivo because both mutants showed a reduction in cell wall Gal and the overexpressors accumulated Gal in the leaf cell wall. Recently, it was demonstrated that the Gal content of the cell wall could be easily manipulated (35); this is probably due to the extension of galactan side chains on the RG-I backbone. In contrast, no changes in the levels of Rha were observed in either the urgt1 mutants or ...
Floyd S, Favre C, Lasorsa FM, Leahy M, Trigiante G, Stroebel P, Marx A, Loughran G, OCallaghan K, Marobbio CMT, Slotboom DJ, Kunji ERS, Palmieri F & OConnor R (2007) The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Mol Biol Cell 18, 3545-55 ...
The latest update with this pregnancy is that I now have to do twice weekly testing for polyhydramnios. We noticed on one of my ultrasounds that my fluid level is a little high which can indicate all sorts of things. Luckily, Wallace seems to be drinking, peeing, and growing just fine. Praise the Lord hes healthy! So theres no explanation for my (slight) excess of amniotic fluid. Now I just do NSTs on Mondays (which is easy because Im already at the office) and BPPs on Thursdays (which means I bring my little buddy Wilson along with me ...
Affiliation:山梨大学,総合研究部,医学研究員, Research Field:Urology,Urology, Keywords:TRP,VNUT,Clock,尿路,ATP,下部尿路機能障害,膀胱上皮下の神経細胞,膀胱上皮,排尿障害,Boturinus toxin, # of Research Projects:3, # of Research Products:4
NPI Number: 1487696910. Healthcare provider: DR. ANACE H SAID M.D.. Practice location address: 85 BARNES RD STE 202 WALLINGFORD, CT, 06492
Plasmonic gold nanostars (NSts) demonstrate an enhanced electric field in their surrounding due to large number of hot spots on their surface resulting in a unique ability to confine light within a nanometric volume. We are demonstrating beneficial properties of NSts as signal enhancers for tissue and cell imaging using optical coherence tomography (OCT), microscopy, surface-enhanced vibration spectroscopy (SEVS), including surface-enhanced Raman scattering (SERS), and surface-enhanced infrared absorption spectroscopy (SEIRAS) with an attenuated total reflectance (ATR) and infrared reflection-absorption spectroscopy (IRRAS) configurations. Scattering ability of gold NSts with various sizes was investigated by OCT capillary imaging and light and confocal microscopy in vitro. The variation of NSts sizes allows one to shift plasmon resonance up to 1300 nm. The most intensive scattering signals were found from the largest NSts. NSts were applied in SEVS scenarios using plasmonic chip-based systems ...
The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia. This antibody is predicted to not cross-react with the highly homologous Slc35D2. ...
The NPI Challenge for Medical Practices February 13, 2007. Discussion Points. Background The NPI Challenge Preparing for the NPI Recommendations Additional resources . Background. NPI Purpose. The purpose of the National Provider Identifier Slideshow 1456646 by uriel
Protein name: VNUT Aliases: N/D Substrates: purine nucleotides Transport type: electrogenic, Cl- dependent Tissue and cellular expression: brain (neurons), adrenal, thyroid Subcellular expression: synaptic vesicle Disease: none Locus: 20q13.33 Sequence ID: NP_071365.3, Gene ID: 63910 ...
Ez Medical Center Inc. is provider located at Hialeah FL. Ez Medical Center Inc. NPI is 1336223692 and taxonomy code is 174400000X.
Read user reviews, compare products and contact manufacturers of Thin Layer Chromatography products, including chambers, HPTLC and plate equipment on SelectScience.
Methods and results A 26-family linkage study followed by fine mapping was performed in a cohort of 1284 KD subjects and their family members (total 3248 individuals). Suggestive evidence of disease linkage (logarithm of odds (LOD) ≥3.0, p,1.00×10−4) was found for five genomic locations (Chr 3q, 4q, 10p, 13q, 21q). Two of these loci (Chr 4q and Chr 13q) overlapped with validated findings from a recent KD genome-wide association study. Fine mapping analysis revealed three single nucleotide polymorphisms (SNPs) in ATP-binding cassette, subfamily C, member 4 (ABCC4) underlying the Chr 13q linkage peak showing evidence of association to KD (lowest p=8.82×10−5; combined OR 2.00, 95% CI 1.41 to 2.83). ABCC4 is a multifunctional cyclic nucleotide transporter that stimulates the migratory capacity of dendritic cells. It is also a mediator of prostaglandin efflux from human cells and is inhibited by non-steroidal anti-inflammatory medications such as aspirin. ...
Uracil permease, UraA. The crystal structure of UraA with bound uracil at 2.8 Å resolution is available (PDB: 3QE7) (Lu et al., 2011). UraA has a novel structural fold, with 14 TMSs divided into two inverted repeats. A pair of antiparallel β-strands is located between TMS3 and TMS10 and has an important role in structural organization and substrate recognition. The structure is spatially arranged into a core domain and a gate domain. Uracil, located at the interface between the two domains, is coordinated mainly by residues from the core domain. Structural analysis suggests that alternating access of the substrate may be achieved through conformational changes of the gate domain. Multiscale molecular dynamics simulations of the UraA symporter in phospholipid bilayers revealed a closed state with 3 high affinity binding sites for cardolipin (Kalli et al. 2015).The crystal structure of UraA bound to uracil in an occluded state at 2.5 A resolution (Yu et al. 2017). UraA shows substantial motions ...
The biosynthesis of sialic acid-containing glycoconjugates is crucial for the development of vertebrate life. Cytidine monophosphate-sialic acid synthetase (CSS) catalyzes the metabolic activation of sialic acids. In vertebrates, the enzyme is chimeric, with the N-terminal domain harboring the synthetase activity. The function of the highly conserved C-terminal domain (CSS-CT) is unknown. To shed light on its biological function, we solved the X-ray structure of murine CSS-CT to 1.9 Šresolution. CSS-CT is a stable shamrock-like tetramer that superimposes well with phosphatases of the haloacid dehalogenase superfamily. However, a region found exclusively in vertebrate CSS-CT appears to block the active-site entrance. Accordingly, no phosphatase activity was observed in vitro, which points toward a nonenzymatic function of CSS-CT. A computational three-dimensional model of full-length CSS, in combination with in vitro oligomerization studies, provides evidence that CSS-CT serves as a platform for ...
2/5/04 Post-Delivery (35 wks, 4 days) by Christie. As I sit here and write this, it is hard to believe what has happened over the past two weeks. On January 21, I had an appointment with Dr K. The ultrasound on that day showed that the baby was continuing to lag behind in growth. She was now approximately 3+ weeks behind. It also put her teetering on the 10% mark. Also, he was a little concerned about blood flow through the cord. So, Dr. K told me to go home and get a few things and check into the hospital for monitoring. I would be on bed rest and non-stress tests (NST) twice a day. He repeated the u/s in the morning with one of his colleagues. Dr G had more experience with cord issues, and he checked out the baby and cord. He felt that everything looked okay with the flow.. So, I was taken back to bed and the baby was monitored twice daily. These NSTs showed that baby was doing great. I just had to take it easy. I was scheduled for another u/s on Sunday morning (1/25) to determine if there was ...
When I was seeing Dr. C during Avas pregnancy, I had to fight and fight and fight to get diagnosed and put on Actigall. I called him numerous times during Christmas break, even calling on Christmas Day to state that I would be going to the hospital for testing. I was in complete misery, wasnt sleeping, itching 24/7 and I had a doctor who was skeptical of it being cholestasis because its such a rare condition. When I finally got in to his office after having tests done at the hospital, I was armed with print-out after print-out from the internet in case I had to basically be my own lawyer and fight for my rights as a patient. Thankfully he finally relented at that appointment and put me on the medication, and from there it was smooth sailing - I was carefully monitored the rest of the pregnancy and followed standard protocol for cholestasis: Actigall, follow-up blood work to check my bile acid levels, bi-weekly NSTs, and a 37 week induction date - which thankfully was unnecessary since Ava ...
When I was seeing Dr. C during Avas pregnancy, I had to fight and fight and fight to get diagnosed and put on Actigall. I called him numerous times during Christmas break, even calling on Christmas Day to state that I would be going to the hospital for testing. I was in complete misery, wasnt sleeping, itching 24/7 and I had a doctor who was skeptical of it being cholestasis because its such a rare condition. When I finally got in to his office after having tests done at the hospital, I was armed with print-out after print-out from the internet in case I had to basically be my own lawyer and fight for my rights as a patient. Thankfully he finally relented at that appointment and put me on the medication, and from there it was smooth sailing - I was carefully monitored the rest of the pregnancy and followed standard protocol for cholestasis: Actigall, follow-up blood work to check my bile acid levels, bi-weekly NSTs, and a 37 week induction date - which thankfully was unnecessary since Ava ...
Sari Kaplan-hasson PH.D. is physically located at New York NY. Sari Kaplan-hasson PH.D. npi is 1194025288 and taxonomy code is 103TC0700X.
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11 products from 7 suppliers. Compare and order Solute Carrier Family 26, Member 4 ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. Recommended products for the most popular species. Our scientists will help you find the right ELISA kit for your needs.
NTT Communications Corporation, the ICT solutions and international communications business within the NTT Group, announced today that they will begin deploying an ultra-large-capacity, space-saving and energy-saving 400Gbps (400G) optical transmission system in data centers for network connection.
pep:known chromosome:VEGA66:1:131744022:131771504:1 gene:OTTMUSG00000021566 transcript:OTTMUST00000051188 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Slc26a9 description:solute carrier family 26 member 9 ...
NTTドコモの中村維夫社長は6月13日,iPhoneの販売契約に関する本誌の質問に対し「(国内の販売契約は)排他ではないと聞いている」と,契約獲得を続行する方針を示唆した。「できれば1番目に欲しかった」として,先行された悔しさをにじませるとともに,2番目の獲得を目指す方向性を示した。 ...
Myc-DDK-tagged ORF clone of Homo sapiens solute carrier family 38, member 8 (SLC38A8) as transfection-ready DNA - 10 µg - OriGene - cdna clones
IT and telecom services provider NTT Communications Corporation (NTT Com), has launched the international data network services in India through its affiliate
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View mouse Slc12a7 Chr13:73733094-73816754 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012 ...