Peptides , Signal Transduction Peptides , Steroid Receptor Coactivator-1, SRC-1 (686-700); This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.; RHKILHRLLQEGSPS; H-Arg-His-Lys-Ile-Leu-His-Arg-Leu-Leu-Gln-Glu-Gly-Ser-Pro-Ser-OH

p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors. In a search for additional cellular targets of p300/CBP, a protein-protein cloning strategy, surprisingly identified SRC-1, a coactivator involved in nuclear hormone receptor transcriptional activity, as a p300/CBP interactive protein. p300 and SRC-1 interact, specifically, in vitro and they also form complexes in vivo. Moreover, we show that SRC-1 encodes a new member of the basic helix-loop-helix-PAS domain family and that it physically interacts with the retinoic acid receptor in response to hormone binding. Together, these results implicate p300 as a component of the retinoic acid signaling pathway, operating, in part, through specific interaction with a nuclear hormone receptor coactivator, SRC-1.. ...

Université de Liège - ULg , Département des sciences biomédicales et précliniques , Biologie de la différenciation sexuelle du cerveau ,] ...

In vitro studies reveal that nuclear receptor coactivators enhance the transcriptional activity of steroid receptors, including estrogen (ER) and progestin receptors (PR), through ligand-dependent interactions. Whereas work from our laboratory and ot

BioAssay record AID 1808 submitted by The Scripps Research Institute Molecular Screening Center: Summary of probe development efforts to identify agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma).

in Hormones & Behavior (2005), 48. Steroid receptor coactivators such as SRC-1 significantly modulate the expression of steroid-dependent physiological and behavioral characteristics in birds and mammals. Changes in coactivator protein ... [more ▼]. Steroid receptor coactivators such as SRC-1 significantly modulate the expression of steroid-dependent physiological and behavioral characteristics in birds and mammals. Changes in coactivator protein expression are therefore likely to affect receptor-mediated transcriptional activity. We previously reported a tissue-dependent regulation of SRC-1 mRNA and protein levels by sex, stress and testosterone in the quail brain. In addition, SRC-1 expression has been shown to vary in mammals during development or in adulthood as a function of seasonal variation in photoperiod. We describe here tissue-specific changes of SRC-1 expression over the course of the day in quail. SRC-1 protein quantified by Western blots in the hindbrain gradually increased in ...

Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.

Abstract. The nuclear receptor coactivator-6 (NCOA6, AIB3, PRIP, ASC-2, TRBP, RAP250 or NRC) is a co-activator for nuclear hormone receptors and certain other transcription factors. NCOA6 plays an important role in embryonic development, adipocyte differentiation, metabolism and breast carcinogenesis. The human and mouse NCOA6 genes had 15 and 14 previously identified exons, respectively. This study further identified an alternatively spliced exon 11b (E11b) in human or E10b in mouse, which codes a short polypeptide and a Stop codon, resulting in splicing variants lacking the last four exon-coded polypeptide. Analyses of mouse testis NCOA6 mRNAs identified four alternatively spliced variants, NCOA6-α (without E10b), -β (without E10a and E10b), -γ (with E10a and E10b) and -δ (without E10a but with E10b). These isoforms were detected in multiple mouse tissues and in MDA-MB-435 human cells. NCOA6-α and -β are mainly located in the nucleus; NCOA6-γ is located in both cytoplasm and nucleus; ...

TY - JOUR. T1 - Global characterization of transcriptional impact of the SRC-3 coregulator. AU - Lanz, Rainer B.. AU - Bulynko, Yaroslava. AU - Malovannaya, Anna. AU - Labhart, Paul. AU - Wang, Liguo. AU - Li, Wei. AU - Qin, Jun. AU - Harper, Mary. AU - OMalley, Bert W.. PY - 2010/4/1. Y1 - 2010/4/1. N2 - The nuclear receptor and bona fide oncogene, steroid receptor coactivator-3 (SRC-3, AIB1), acts as a master transcriptional regulator of breast cancer by transducing growth signals via the estrogen receptor α (ER). In this resource paper, we present the genome-wide localization analysis of SRC-3 chromatin affinity sites in MCF-7 human breast cancer chromatin and compare the cis binding sites to global cartographies for ER and FoxA1. By correlating their gene proximal binding sites to integrated gene expression signatures, and in combination with gene ontology analyses, we provide a functional classification of estradiol-induced gene regulation that further highlights an intricate ...

The nuclear receptor transcriptional activity is regulated by coregulators including coactivators (SRC-1, SRC-2 and SRC-3, RIP140 etc.) and…

Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program are not completely understood; however, these factors have potential as cancer therapy targets. Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. SRC-2 was highly elevated in a variety of tumors, especially in prostate cancer, in which SRC-2 was amplified and overexpressed in 37% of the metastatic tumors evaluated. In prostate cancer cells, SRC-2 stimulated reductive carboxylation of α-ketoglutarate to generate citrate via retrograde TCA cycling, promoting lipogenesis and reprogramming of glutamine metabolism. Glutamine-mediated nutrient signaling activated SRC-2 via ...

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Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1 ...

Health, ...A new study provides valuable insight into a previously undescribed me...It is well established that steroid receptor coactivator-3 (SRC-3/AIB1...Recently it was shown that phosphorylation of SRC-3 by specific kinas...The researchers found that aPKC stabilized cellular SRC-3 protein leve...,Atypical,protein,kinase,C,stabilizes,SRC-3,levels,in,breast,cancer,cells,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

The steroid receptor coactivator 3 gene, SRC-3, was identified in a region on chromosome 20 that was frequently amplified in breast cancer. The SRC-3 protein was shown to act in the nucleus to regulate the transcription of genes involved in growth and development. Long et al. report that the SRC-3 transcript can undergo alternative splicing to produce two proteins with distinct personalities. In comparison to the full-length protein, SRC-3Δ4 lacks exon 4, which encodes the DNA-binding domain and a nuclear localization signal. Like SRC-3, the SRC-3Δ4 isoform is overexpressed in breast cancer and other tumors, but it localizes to the plasma membrane and acts as a cytoplasmic signaling coactivator by mediating epidermal growth factor (EGF)-induced cell migration. SRC-3Δ4 couples the EGF receptor to one of its downstream signaling effectors, focal adhesion kinase. EGF is known to promote cancer cell migration and metastasis, and overexpression of SRC-3Δ4 in breast cancer cells induced metastasis ...

Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program are not completely understood; however, these factors have potential as cancer therapy targets. Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. SRC-2 was highly elevated in a variety of tumors, especially in prostate cancer, in which SRC-2 was amplified and overexpressed in 37% of the metastatic tumors evaluated. In prostate cancer cells, SRC-2 stimulated reductive carboxylation of α-ketoglutarate to generate citrate via retrograde TCA cycling, promoting lipogenesis and reprogramming of glutamine metabolism. Glutamine-mediated nutrient signaling activated SRC-2 via ...

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3 ...

A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER ...

Compare proline-rich nuclear receptor coactivator 2 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.

Noncompaction cardiomyopathy (NCC) is a congenital heart disease that causes ventricular dysfunction and high mortality rate in children. The mechanisms responsible for NCC are still unknown. The steroid receptor coactivator-1 (SRC-1) and SRC-3 are transcriptional coactivators for nuclear hormone receptors and certain other transcription factors that regulate many genes in development and organ function. However, the roles of SRC-1/3 in heart morphogenesis, function and NCC occurrence are unknown. This study aims to examine the spatial and temporal expression patterns of SRC-1/3 in the heart and investigate the specific roles of SRC-1/3 in heart development, function and NCC occurrence. Immunochemical analysis detected SRC-1/3 expressions in the proliferating cardiomyocytes of mouse heart at prenatal and neonatal stages, while these expressions disappeared within two weeks after birth. Through generating and characterizing mouse lines with global or cardiomyocyte-specific knockouts of SRC-1/3, ...

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Looking for online definition of NCoA-3 in the Medical Dictionary? NCoA-3 explanation free. What is NCoA-3? Meaning of NCoA-3 medical term. What does NCoA-3 mean?

DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.

Mori K، Kato H (2002). A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus. FEBS Lett. 520 (1-3): 127-32. PMID 12044884. doi:10.1016/S0014-5793(02)02803-X. ...

ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1. - Mechanism of Action & Protocol.

SRC3 antibody [0.T.198] (nuclear receptor coactivator 3) for IP, WB. Anti-SRC3 mAb (GTX14139) is tested in Human samples. 100% Ab-Assurance.

Synchrony of the mammalian circadian clock is achieved by complex transcriptional and translational feedback loops centered on the BMAL1:CLOCK heterodimer. Modulation of circadian feedback loops is essential for maintaining rhythmicity, yet the role of transcriptional coactivators in driving BMAL1:CLOCK transcriptional networks is largely unexplored. Here, we show diurnal hepatic steroid receptor coactivator 2 (SRC-2) recruitment to the genome that extensively overlaps with the BMAL1 cistrome during the light phase, targeting genes that enrich for circadian and metabolic processes. Notably, SRC-2 ablation impairs wheel-running behavior, alters circadian gene expression in several peripheral tissues, alters the rhythmicity of the hepatic metabolome, and deregulates the synchronization of cell-autonomous metabolites. We identify SRC-2 as a potent coregulator of BMAL1:CLOCK and find that SRC-2 targets itself with BMAL1:CLOCK in a feedforward loop. Collectively, our data suggest that SRC-2 is a ...

These studies have demonstrated that phosphorylation of the EGF-R is induced during the ET-1-stimulated growth response of ovarian carcinoma cells. Such transactivation of the EGF-R is accompanied by a coordinate increase in the phosphorylation of the adaptor molecule Shc, and its recruitment in complexes with the SH2/SH3 adaptor, Grb2. These findings suggest the existence of an EGF-R-dependent route leading to the ras/MAPK activation pathway. Furthermore, the ET-1-induced phosphorylation of Erk 2 MAPK is partially dependent on EGF-R transactivation, as indicated by the effects of EGF-R kinase inhibition by tyrphostin AG1478. There is now abundant evidence that activation of GPCRs, in particular by ligands that elicit mitogenic responses, can induce transactivation of receptor tyrosine kinases. These transactivations include platelet-derived growth factor-R and EGF-R activation by angiotensin II in vascular smooth muscle cells (43) ; EGF-R and p185neu/ErbB2 activation by lysophosphatidic acid ...

Complete information for NCOA4 gene (Protein Coding), Nuclear Receptor Coactivator 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Complete information for NCOA3 gene (Protein Coding), Nuclear Receptor Coactivator 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

NCOA2/GRIP1 (nuclear receptor coactivator 2/glucocorticoid receptor-interacting protein 1 (GRIP1)) is a 159 kD member of the p160/steroid receptor…

NCOA7 antibody (nuclear receptor coactivator 7) for ELISA, WB. Anti-NCOA7 pAb (GTX87951) is tested in Human samples. 100% Ab-Assurance.

Get this from a library! Steroid Receptors in Health and Disease. [Virinder K Moudgil] -- During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and ...

Coactivator (genetics) A coactivator is a protein that increases gene expression by binding to an activator (or transcription factor) which contains a DNA

NCOA4兔多克隆抗体(ab111885)可与人样本反应并经IHC实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。

Looking for online definition of chylomicrons in the Medical Dictionary? chylomicrons explanation free. What is chylomicrons? Meaning of chylomicrons medical term. What does chylomicrons mean?

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response (By similarity).

Purified TR-FRET Androgen Receptor Coactivator Assay Kit from Creative Biomart. TR-FRET Androgen Receptor Coactivator Assay Kit can be used for research.

Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. An imbalance caused by increased E2 action and/or decreased P4 action can result in abnormal endometrial proliferation and, ultimately, endometrial adenocarcinoma, the fourth most common cancer in women. Jeong’s laboratory has special interests in research relating to womens health, particularly infertility and cancer using genetically engineered mouse models.. We have identified mitogen-inducible gene 6 (Mig-6) as a down stream target of progesterone receptor (PR) and steroid receptor coactivator (SRC-1) action in the uterus. Mig-6 plays a critical role in the regulation of uterine function and the development of endometrial hyperplasia and cancer in the presence of steroid hormones. Importantly, the observation that endometrial carcinomas from women have a significant reduction in MIG-6 expression provides compelling support for an important growth regulatory role for Mig-6 in the uterus of ...

NCOA4 - NCOA4 (untagged)-Human nuclear receptor coactivator 4 (NCOA4), transcript variant 5 available for purchase from OriGene - Your Gene Company.

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NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4] ...

AIB1 (amplified in breast cancer I) is a member of the p160 steroid receptor coactivator family. AIB1 is frequently overexpressed in breast cancer and has functions that promote oncogenesis that are independent of estrogen receptor (ER) coactivation. We investigated prognostic significance of AIB1 and relationship between AIB1 and ER, progesterone receptor (PR), androgen receptor (AR), DAX-1, and HER2. RNA in situ hybridization (ISH) and immunohistochemical (IHC) staining for AIB1, IHC staining for ER and the progesterone receptor (PR) and IHC staining and silver in situ hybridization (SISH) for HER2 were performed for 185 breast cancer cases. A high level of expression of AIB1 mRNA was observed in 60.0% of tumors. IHC analysis detected AIB1 positivity in 47.3% of tumors, which did not correlate with AIB1 mRNA expression (p = 0.24, r = 0.10). AIB1 protein expression correlated with AR and DAX-1 expression (p = 0.01, r = 0.22 and p = 0.02, r = 0.21, respectively) but not with ER or PR expression (p = 0

The mechanisms by which nuclear receptors transmit a hormone binding signal to core transcription machinery have been the focus of intensive research. These efforts have lead to the identification and characterization of several distinct multiprotein complexes which directly interact with agonist-bound nuclear receptors (9, 16, 28, 45, 46). The SRC-1 family of nuclear receptor coactivators appear to play a critical role in mediating the association of one of these complexes to nuclear receptors. This complex has been shown to contain potent HAT activities in p300-CBP and also the p300/CBP-associated factor PCAF. Additionally, these factors have been identified in complexes that contain intrinsic chromatin remodeling activity. These findings suggest that the SRC-1-containing complex may have as its primary purpose the chemical modification of the chromatin surrounding a target gene to which it is recruited. A second complex, identified on the basis of its ability to interact with activated ...

Progestin withdrawal is a crucial event for the onset of labor in many mammalian species. However, in humans the mechanism of a functional progestin withdrawal is unclear, because progestin concentrations do not drop in maternal plasma preceding labor. We report the presence of two novel functional membrane progestin receptors (mPRs), mPRalpha and mPRbeta, in human myometrium that are differentially modulated during labor and by steroids in vitro. The mPRs are coupled to inhibitory G proteins, resulting in a decline in cAMP levels and increased phosphorylation of myosin light chain, both of which facilitate myometrial contraction. Activation of mPRs leads to transactivation of PR-B, the first evidence for cross-talk between membrane and nuclear PRs. Progesterone activation of the mPRs leads also to a decrease of the steroid receptor coactivator 2. Our data indicate the presence of a novel signaling pathway mediated by mPRs that may result in a functional progestin withdrawal, shifting the balance from a

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ACTR1B山羊多克隆抗体(ab13802)可与人样本反应并经WB实验严格验证，被1篇文献引用。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。

My laboratory is focused on the transcriptional regulation of estrogen receptor (ER) signaling pathways by nuclear receptor co-factors. Estrogen receptors regulate cell proliferation, differentiation and cell cycle control in a cell- and tissue-specific manner. The effect of estrogen in etiology and progression of breast cancer is ascribed to ER-promoted cell proliferation. We have discovered that some ER co-regulatory proteins regulate ER-mediated growth inhibition rather than proliferation. We are in the process of exploring the molecular mechanisms by which nuclear receptor coactivators regulate ER-mediated growth inhibition and attempting to develop novel chemotherapy strategies to treat ER-positive breast cancer. Furthermore, we aim to understand the crosstalk between ER pathways and other growth factors and kinase networks, as these mechanisms account for the intrinsic or acquired tamoxifen resistance in endocrine therapy.. An important epigenetic route to carcinogenesis involves the ...

Although estrogens have long been thought to be protective against cardiovascular disease, this assumption has been challenged by clinical trials that failed to corroborate such protective effects of hormone replacement therapy in postmenopausal women. Umetani et al. found that the cholesterol metabolite 27-hydroxycholesterol (27HC, which is found in atherosclerotic lesions) competed with estradiol for binding to estrogen receptor α and β (ERα and ERβ), inhibited estradiol-dependent activation of transcriptional activity of the receptors, and inhibited the estradiol-dependent association of ERβ with the transcriptional coactivator SRC-1. In mice fed diets rich in cholesterol and fat, hypercholesterolemia was associated with increased vascular concentrations of 27HC, so that it reached concentrations comparable to those affecting ER function. 27HC inhibited the estradiol-dependent increase in mRNA encoding inducible and endothelial nitric oxide synthase (iNOS and eNOS) in mouse aortic ...

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Hop on to get the meaning of p/ CIP acronym / slang / Abbreviation. The Medical & Science Acronym / Slang p/ CIP means... AcronymsAndSlang. The p/ CIP acronym/abbreviation definition. The p/ CIP meaning is p300/ CREB-binding protein (CBP)-interacting protein. The definition of p/ CIP by AcronymAndSlang.com

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.