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ab165788 is not available and we regret any inconvenience caused. View our alternatives for ab165788 or you can download the archived datasheet PDF from this page.
Image Credit: Good Search I recently received a comment from someone who included some information about Nut Midline Carcinoma. If you are familiar with this aggressive cancer, and want a blog that focuses on it, heres a link. About Nut Midline Carcinoma. http://stridesforstephenstepstocurenmc.wordpress.com/stephensstory/
Molecular cloning and characterisation of a human nuclear protein designated BM28 is reported. On the amino acid level this 892 amino acid protein, migrating on SDS-gels as a 125 kDa polypeptide, shares areas of significant similarity with a recently defined family of early S phase proteins. The members of this family, the Saccharomyces cerevisiae Mcm2p, Mcm3p, Cdc46p/Mcm5p, the Schizosaccharomyces pombe Cdc21p and the mouse protein P1 are considered to be involved in the onset of DNA replication. The highest similarity was found with Mcm2p (42% identity over the whole length and higher than 75% over a conservative region of 215 amino acid residues), suggesting that BM28 could represent the human homologue of the S. cerevisiae MCM2. Using antibodies raised against the recombinant BM28 the corresponding antigen was found to be localised in the nuclei of various mammalian cells. Microinjection of anti-BM28 antibody into synchronised mouse NIH3T3 or human HeLa cells presents evidence for the ...
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We present a systematic analysis of sequence motifs found in metazoan protein factors involved in constitutive pre-mRNA splicing and in alternative splicing regulation. Using profile analysis we constructed a database enriched in protein sequences containing one or more presumptive copies of the RNA-recognition motif (RRM). We provide an accurate alignment of RRMs and structure-based criteria for identifying new RRMs, including many that lack the prototype RNP-1 submotif. We present a comprehensive table of 125 sequences containing 252 RRMs, including 22 previously unreported RRMs in 17 proteins. The presence of a putative RRM in these proteins, which are implicated in a variety of cellular processes, strongly suggests that their function involves binding to RNA. Unreported homologies in the RRM-enriched database to the metazoan SR family of splicing factors are described for an Arg-rich human nuclear protein and two yeast proteins (S. pombe mei2 and S. cerevisiae Npl3). We have rigorously ...
We present a systematic analysis of sequence motifs found in metazoan protein factors involved in constitutive pre-mRNA splicing and in alternative splicing regulation. Using profile analysis we constructed a database enriched in protein sequences containing one or more presumptive copies of the RNA-recognition motif (RRM). We provide an accurate alignment of RRMs and structure-based criteria for identifying new RRMs, including many that lack the prototype RNP-1 submotif. We present a comprehensive table of 125 sequences containing 252 RRMs, including 22 previously unreported RRMs in 17 proteins. The presence of a putative RRM in these proteins, which are implicated in a variety of cellular processes, strongly suggests that their function involves binding to RNA. Unreported homologies in the RRM-enriched database to the metazoan SR family of splicing factors are described for an Arg-rich human nuclear protein and two yeast proteins (S. pombe mei2 and S. cerevisiae Npl3). We have rigorously ...
Active Motif provides a large number of recombinant bromodomain proteins for studies of bromodomain function in transcriptional regulation and chromatin remodeling.
Changes in nuclear proteome inrinmutant reveal the potential downstream targets ofRIN. (a) Nuclear proteins were isolated from wild-type (WT)and rin mutant frui
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Shop Nuclear protein ELISA Kit, Recombinant Protein and Nuclear protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
DAXX ; BING2 ; DAP6 ; Death domain-associated protein 6 ; Daxx ; hDaxx ; ETS1-associated protein 1 ; EAP1 ; Fas death domain-associated ...
Cavellán, E.; Asp, P.; Percipalle, P.; Farrants, A-Kristin.Ostlund., 2006: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription
Adult Nuclear Protein Normal Eye Lysate, 0.1 mg. Tissue total protein is prepared from whole tissue homogenates and presents a consistent pattern on SDS-PAGE analysis.
SPIN-2, 0.1 ml. SPIN-2 is a novel nuclear protein that functions to regulate cell cycle progression and this activity is related to the inhibition of apoptosis following the removal of essential growth factors.
POLDIP2鸡多克隆抗体(ab26188)可与小鼠, 大鼠, 人样本反应并经WB, ICC实验严格验证,被2篇文献引用。所有产品均提供质保服务,中国75%以上现货。
ヤギ・ポリクローナル抗体 ab31319 交差種: Hu 適用: WB,ELISA…Nucleophosmin抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody 製品。国内在庫と品質保証制度も充実。
TNFAIP8L3兔多克隆抗体(ab111524)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Nuclear protein in testis (NUT) midline carcinoma is an exceedingly rare subtype of squamous poorly-differentiated carcinoma and is considered one of the most aggressive human solid tumors [1-3]. NUT midline carcinoma is a relatively new entity, that may likely be under-recognized and under-diagnosed. All ages and organs might be affected, but most frequently NUT midline carcinoma arises along the trunk or the head and, in particular, in midline structures such as the mediastinum [1-3]. NUT midline carcinoma is characterized by the pathognomonic chromosomal rearrangement between the NUT gene with either bromodomain-containing protein 4 (BRD4) or, less frequently, with BRD3 (on chromosome 9), leading to the fusion genes BRD4-NUT or BRD3-NUT, respectively [1-3]. BRD is a DNA reader that activates transcription by binding to acetyl-modified lysine residues of histone tails [1, 3, 4]. The expression of several oncogenes, including transcription factors and MYC, is epigenetically regulated by BRD. ...
TY - JOUR. T1 - Intrapericardial NUT Midline Carcinoma. T2 - Unusual Presentation of a Rare Tumor and Literature Review with Management Considerations. AU - Samples, Stefani. AU - Gleditsch, Katrina. AU - Polimenakos, Anastasios. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Rearrangements in the nuclear protein in testis (NUT) gene cause carcinomas that represent a rare but aggressive tumor type that often present at advanced stages in midline structures. Survival rarely exceeds 12 months from the time of diagnosis. There have been no reports of a primary cardiac presentation, and few studies have reported on the numerous treatment strategies. Given their aggressive and invasive nature, NUT midline carcinomas present a therapeutic dilemma. Treatment may include surgical resection, chemotherapy, or radiotherapy, but no consistently successful treatment has been established. Surgical resection is indicated to reduce symptomatic mass effect whenever present. Novel therapies with bromodomain extra-terminal ...
Excellgen Brahma-related Gene 1 protein, wild type, BRG1, SMARCA4 [RP-22] - Product Name Brahma-related Gene 1, BRG1, SMARCA4 Size 5,000 U Description The wild type human brahma-related gene 1 (Brg1) encodes a protein of 1,647 amino acids that contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription regulation (1-3). BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes
Growth factor receptor levels are aberrantly high in diverse cancers, driving the proliferation and survival of tumor cells. Understanding the molecular basis for this aberrant elevation has profound clinical implications. Here we show that the pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) suppresses receptor tyrosine kinase (RTK) signaling output by a previously unidentified epigenetic mechanism unrelated to its previously described function as the hydrophobic motif phosphatase for the protein kinase AKT, protein kinase C, and S6 kinase. Specifically, we show that nuclear-localized PHLPP suppresses histone phosphorylation and acetylation, in turn suppressing the transcription of diverse growth factor receptors, including the EGF receptor. These data uncover a much broader role for PHLPP in regulation of growth factor signaling beyond its direct inactivation of AKT: By suppressing RTK levels, PHLPP dampens the downstream signaling output of two major oncogenic pathways, the
Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell cycle associated genes and therefore involved in cell cycle progression. Brd2 is expressed in proliferating neuronal progenitors, displays cell cycle-stimulating activity and, when overexpressed, impairs neuronal differentiation. Paradoxically, Brd2 is also detected in differentiating neurons. To shed light on the role of Brd2 in the transition from cell proliferation to differentiation we have looked for Brd2 interacting proteins upon induction of neuronal differentiation. Surprisingly, we have identified the growth factor Pleiotrophin (Ptn). Ptn antagonizes the cell cycle-stimulating activity associated with Brd2, thus enhancing induced neuronal differentiation. Moreover, Ptn knockdown reduces neuronal differentiation. Ptn-mediated antagonism of Brd2 has been assessed in a cell differentiation model and in two embryonic processes associated with the neural tube: spinal cord neurogenesis ...
SIAH2 (seven in absentia homolog 2 (Drosophila)), Authors: Jianfei Qi, Zeev Ronai. Published in: Atlas Genet Cytogenet Oncol Haematol.
Class II transactivator (CIITA) is a global transcriptional coactivator of human leukocyte antigen-D (HLA-D) genes. CIITA contains motifs similar to guanosine triphosphate (GTP)-binding proteins. This report shows that CIITA binds GTP, and mutations in these motifs decrease its GTP-binding and transactivation activity. Substitution of these motifs with analogous sequences from Ras restores CIITA function. CIITA exhibits little GTPase activity, yet mutations in CIITA that confer GTPase activity reduce transcriptional activity. GTP binding by CIITA correlates with nuclear import. Thus, unlike other GTP-binding proteins, CIITA is involved in transcriptional activation that uses GTP binding to facilitate its own nuclear import. ...
The most common mode of healthcare delivery is through personal, face-to-face contact between a healthcare provider and a beneficiary (patient). There is, however, an increasing trend towards the provision of healthcare in the absence of personal contact. This limit of contact during patient care is known as in absentia health care. In Absentia healthcare, or distance medicine, occurs when the patient and care giver are at different locations, but still communicate by audio and video, or sometimes without any personal contact. A face-to-face contact is often a necessary prelude to rendering health care. This, however, may not be necessary for care; in fact current technologies permit with no prior or concurrent contact.[1][2] Some people argue that this type of in absentia medical care may derail the traditional sequences of examination, diagnosis and treatment, and that such a detour may challenge existing values of modern medicine. In absentia care assumes heightened relevance today because ...
Survival time associated PHD finger in Ovarian Cancer 1 (SPOC1) is a novel protein that has not been investigated before. The objective of this research was to investigate and identify endogenous SPOC1 at the cellular level, to characterize its molecular features and to try and identify its putative biological functions. In this study I have been able to show that SPOC1 is a nuclear localized protein that is tightly associated with chromatin in most cell cycle phases. SPOC1 was found to be a very labile protein in the soluble phase with a half-life of approximately 15 minutes, whereas it was stable over hours when associated with chromatin. SPOC1 shows a dynamic regulation in both its expression levels and its chromatin localization through out the cell cycle. During S-phase transition and early S-phase SPOC1 is released from the chromatin and found to localize in the soluble fraction of nuclear lysate and is significantly decreased in its expression levels suggesting that it is degraded. ...
PubMed journal article: Brahma-related gene 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling. Download Prime PubMed App to iPhone, iPad, or Android
TY - JOUR. T1 - Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. AU - Sheng, Guoqing. AU - Xu, Xingshun. AU - Lin, Yung Feng. AU - Wang, Chuan En. AU - Rong, Juan. AU - Cheng, Dongmei. AU - Peng, Junmin. AU - Jiang, Xiaoyan. AU - Li, Shi Hua. AU - Li, Xiao Jiang. PY - 2008/8/1. Y1 - 2008/8/1. N2 - Joubert syndrome is an autosomal recessive disorder characterized by congenital malformation of the cerebellum and brainstem, with abnormal decussation in the brain. Mutations in the Abelson helper integration site 1 gene, which encodes the protein AHI1, have been shown to cause Joubert syndrome. In this study, we found that mouse Ahi1 formed a stable complex with huntingtin-associated protein 1 (Hap1), which is critical for neonatal development and involved in intracellular trafficking. Hap1-knockout mice showed significantly reduced Ahi1 levels, defective cerebellar development, and abnormal axonal decussation. Suppression of Ahi1 also ...
Orderly progression through the cell cycle is essential to maintain ploidy and stability of the genome. For the transition from G2 into mitosis, upstream checkpoint proteins signal the timing of mitotic entry. Among these are checkpoints to detect completion of DNA replication, the absence of genomic lesions, the doubling of cell mass, and the synthesis of macromolecules. Ultimately, these signals up- or downregulate the inhibitory Y15 phosphorylation of Cdc2, the universal switch for the transition from G2 into mitosis. Through controlling the kinases and phosphatases that phosphorylate and dephosphorylate Y15, these checkpoint-signaling pathways work together to ensure that mitosis is initiated only when it will result in two viable and identical daughters. Although most checkpoints halt cell cycle progression in response to an insult, osmotic stress and limited nutrition actually advance mitotic entry in S. pombe (Young and Fantes 1987; Shiozaki and Russell 1995). It is therefore likely that ...
The amount of cellular proteins is a crucial parameter that is known to vary between cells as a function of the replicative passages, and can be important during physiological aging. The process of protein degradation is known to be performed by a series of enzymatic reactions, ranging from an initial step of protein ubiquitination to their final fragmentation by the proteasome. In this paper we propose a stochastic dynamical model of nuclear proteins concentration resulting from a balance between a constant production of proteins and their degradation by a cooperative enzymatic reaction. The predictions of this model are compared with experimental data obtained by fluorescence measurements of the amount of nuclear proteins in murine tail fibroblast (MTF) undergoing cellular senescence. Our model provides a three-parameter stationary distribution that is in good agreement with the experimental data even during the transition to the senescent state, where the nuclear protein concentration changes
This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009 ...
High throughput screening Scientists know that the faulty huntingtin protein causes HD, but how it kills cells is not fully known. By screening hundreds of compounds, scientists hope to find one that prevents the aggregation or cleavage of the mutant huntingtin protein - and thereby stops the cells being killed. If successful, they will try this in tissue culture, then examine the effects on animals carrying the faulty HD gene. If the results of both these are successful, the compound can be safety tested in preparation for human trials. ...
Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntingtons disease, or a symptom thereof.
NPM1 - NPM1 (untagged)-Human nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 3 available for purchase from OriGene - Your Gene Company.
LC3-mHTT-IN-2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons. - Mechanism of Action & Protocol.
Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ. Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment ...
The 1972 Gordon Research Conference on Nuclear Proteins, Chromatin Structure and Gene Regulation will be held in Beaver Dam, WI. Apply today to reserve your spot.
I have been continuing to characterise the huntingtin protein samples I am generating in the lab. You can read about my first attempts to map post-translational modifications by mass spec here. Previously I found phosphorylation modifications on the huntingtin protein which are located on the same sites as huntingtin protein derived from human cells which Read More …. ...
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YAP (yes-associated protein) and TAZ are oncogenic transcriptional co-activators downstream of the Hippo tumor-suppressor pathway. However, whether...
Tumor protein 53 (p53) is a critical regulator of cell cycle and apoptosis that is frequently disabled in human tumors. In many tumor types, p53 is deleted or mutated, but in others p53 is inactivated by overexpression or amplification of its negative regulator mouse double minute 2 (MDM2). A high-t …
Zyagen : Nuclear Protein Products - Antibodies Kits, Reagents & Biochemical Tissue Sections RNA Products cDNA Products Genomic DNA Products Tissue Lysates Products Premade Northern Blots Premade Western Blots Recombinant Proteins & Peptides Tissue Microarrays
Shop Lysine-rich nucleolar protein ELISA Kit, Recombinant Protein and Lysine-rich nucleolar protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Has anyone tried a new product from Sigma for nuclear protein extraction?If so, I would be curious to find out how it worked and if you would recommend this product to others?Please reply to this posting or send an email to [email protected] Thanks, Laki. ...
In collaboration with Dr. Macdonald and others at CHDI, the Isis HD team is working to validate huntingtin lowering biomarkers. Beside the development of assays (investigative procedures) to measure the huntingtin protein in CSF, CHDI is also looking at PET-ligands to measure the effects of ISIS-HTTRx in the brain. The ligand, sometimes called a PET tracer, binds to a target or receptor in the brain, which can be measured in people using PET scan imaging. The team has selected ligands to targets that are altered in HD; the hope is that when huntingtin is lowered the level of these targets will be restored, indicating that ISIS-HTTRx has a desired effect ...
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This review describes the structure and functions of Y-box binding protein 1 ( YB-1) and its homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the participation of Y
Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in pulmonary and nonpulmonary primary tumors. ...
Background. A promising area of research is the analysis of multiplexed nuclear proteins on a per-cell basis and the correlation of multi-protein-based cell phenotype statistics with clinical patterns. Many believe that capturing this information from individual tumor cells, rather than average values for proteins across tumor cell populations, as obtained in singly stained serial sections, or as average values for proteins across homogenized tumor samples, may hold key information about disease state, and thus offer valuable information for diagnosis, prognosis and therapy selection. Objective. To demonstrate that multicolor IHC staining and multispectral imaging can be used to quantify reliably multiple nuclear proteins on a per-cell basis, without significant inter-stain interference or cross-talk. Additionally, our objective is to offer an example of the additional information afforded by multiplexed per-cell IHC. ER and ki67 were chosen for this demonstration because of the recent finding ...
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