Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene. The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. GRCh38: Ensembl release 89: ENSG00000141568 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000039275 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR (Jul 1988). Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol Cell Biol. 8 (4): 1715-24. PMC 363332 . PMID 3260003. Entrez Gene: FOXK2 forkhead box K2. Li C, Lusis AJ, Sparkes R, et al. (1992). Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF. Genomics. 13 (3): ...

GT:ID BAD57449.1 GT:GENE BAD57449.1 GT:PRODUCT putative DNA-binding protein GT:DATABASE GIB00210CH01 GT:ORG nfar0 GB:ACCESSION GIB00210CH01 GB:LOCATION 2771120..2771977 GB:FROM 2771120 GB:TO 2771977 GB:DIRECTION + GB:PRODUCT putative DNA-binding protein GB:PROTEIN_ID BAD57449.1 LENGTH 285 SQ:AASEQ MQQAVAERGPTVLRIALGGQLRKLRESRNITREAAGDAIRGSHAKISRLELGRTGFKERDIRDLLTLYGVVDPAERESFLDLARRANEPGWWHRYSDLLPQWFGQYLGLEQAAWKIRTYEAHLVPGLLQTPDYARAVLALGSDDADTDRRVDVRRRRQEILRRPEPPIVWAVLDEAALHRPVGGVQVHRAQIEHLIELAALPNVTLQVLPYSAGEHAAAGASFSILRFAEAELPDVVYLEHLTSALYLDRTQDLALYRSVMDRLSVQALAPDKSVDWLKNFAAGL GT:EXON 1,1-285:0, SEG 143-,163,ddadtdrrvdvrrrrqeilrr, RP:PDB:NREP 1 RP:PDB:REP 3-,90,2csfA,5e-08,8.0,88/101, HM:PFM:NREP 1 HM:PFM:REP 21-,74,PF01381,6.3e-06,24.5,53/55,HTH_3, RP:SCP:NREP 1 RP:SCP:REP 17-,116,1s4kA,5e-07,20.8,96/120,a.35.1.6, HM:SCP:REP 9-,70,1y9qA1,1.7e-05,29.0,62/0,a.35.1.8,1/1,lambda repressor-like DNA-binding domains, OP:NHOMO 191 OP:NHOMOORG 14 OP:PATTERN ...

GT:ID BAD55361.1 GT:GENE BAD55361.1 GT:PRODUCT putative DNA-binding protein GT:DATABASE GIB00210CH01 GT:ORG nfar0 GB:ACCESSION GIB00210CH01 GB:LOCATION complement(531217..531633) GB:FROM 531217 GB:TO 531633 GB:DIRECTION - GB:PRODUCT putative DNA-binding protein GB:PROTEIN_ID BAD55361.1 LENGTH 138 SQ:AASEQ MADFAARLNKLFETVHPPGRKPHTNAEVAAALTASGHPISKPYLSQLRSGQRTNPSDETVAALAKFFKVKPDYFFNDIYAAKIDHDLELLSQLQGYGLRRLSSRAFDLSEESQNLLTSMAEKLRASEGLPEIPPDGTE GT:EXON 1,1-138:0, BL:SWS:NREP 1 BL:SWS:REP 1-,69,Y1416_COXBU,7e-04,37.9,58/100, RP:PDB:NREP 1 RP:PDB:REP 6-,104,2ao9A,3e-07,10.1,99/117, HM:PFM:NREP 1 HM:PFM:REP 33-,74,PF01381,4.7e-10,36.1,36/55,HTH_3, RP:SCP:NREP 1 RP:SCP:REP 6-,104,2ao9A1,2e-07,10.1,99/117,a.4.1.17, HM:SCP:REP 39-,77,2a6cA1,0.00055,33.3,39/0,a.35.1.13,1/1,lambda repressor-like DNA-binding domains, OP:NHOMO 42 OP:NHOMOORG 31 OP:PATTERN -------------------------------------------------------------------- ...

Complete information for NF1 gene (Protein Coding), Neurofibromin 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Salmonella infections remain a big problem worldwide, causing enteric fever by Salmonella Typhi (or Paratyphi) or self-limiting gastroenteritis by non-typhoidal Salmonella (NTS) in healthy individuals. NTS may become invasive and cause septicemia in elderly or immuno-compromised individuals, leading to high mortality and morbidity. No vaccines are currently available for preventing NTS infection in human. As these invasive NTS are restricted to several O-antigen serogroups including B1, D1, C1 and C2, O-antigen polysaccharide is believed to be a good target for vaccine development. In this study, a strategy of O-serotype conversion was investigated to develop live attenuated S. Typhimurium vaccines against the major serovars of NTS infections. The immunodominant O4 serotype of S. Typhimurium was converted into O9, O7 and O8 serotypes through unmarked chromosomal deletion-insertion mutations. O-serotype conversion was confirmed by LPS silver staining and western blotting. All O-serotype conversion

World NF Awareness Day & Month - This is an awareness day that hits very close to home as I have Neurofibromatosis (NF). My mother, uncle, and cousins have NF. Some cities are gonna Shine A Light on NF on this day. #EndNF #WorldNFDay #Neurofibromatosis. ...

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rtemisinin SOD™ combines pure artemisinin for immune support, green tea extract to promote healthy levels of SOD (superoxide dismutase), curcumin and quercetin for their healthy impact on inflammation and resulting inhibitory affect on NF...

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Fomtide Nf in Telugu - యొక్క ఉపయోగాలు, మోతాదు, దుష్ప్రభావాలు, ప్రయోజనాలు, పరస్పర చర్యలు మరియు హెచ్చరికను కనుగొనండి - Fomtide Nf yokka upayogaalu, mothaadu, dushprabhaavaalu, prayojanaalu, praspara charyalu mariyu hechcharika

受邀对频道 NF^2经典剧集频道 以及 NF^2在播剧集频道 内容进行整理，频道内容与本站无关；本文国外剧集以英文剧名排序，国内剧集以拼音排序；本文由脚本+手动调整方式生成，如有错误，请指出；善...

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Book now at E&E Grill House in New York, explore menu, see photos and read 1401 reviews: Oysters in the half shell were amazing and reasonably priced, but the French onion soup was even better! Would definitely recommend. If staying at Th...

I have had my system running now for a month. All my parameters have been holding firm now for 2 weeks. a week ago we added 4 blue/green chromis, 4 hermit crabs, 1 cleaner shrimp and one coral banded

Second, we found that rapamycin treatment results in reduced mTOR pathway activation throughout the body, as evidenced by decreased p70S6K and S6 phosphorylation in the spleen ( Fig. 6B). However, there was no significant effect of rapamycin treatment on the levels of Akt activation. In this regard, we found no evidence for feedback between mTOR blockade and Akt activity as previously reported in tumor cell lines ( 41, 42) or in cells or tumors lacking expression of the tuberous sclerosis complex genes ( 43, 44). The lack of feedback activation of Akt following rapamycin treatment suggests that mTOR inhibition is unlikely to result in compensatory changes in signaling within NF1-deficient cells that would counteract the inhibitory effects of rapamycin on NF1-associated optic glioma growth. Furthermore, these findings highlight differences between the consequences of NF1 and TSC gene inactivation, which both control mTOR signaling, on cell growth control pathways, and suggest that loss of ...

Perform reliable PCR with Bio-Rads Ilf2 primer pair, for Mouse. Designed for EvaGreen-based detection with digital PCR (ddPCR).

Neuroblastoma is an extra-cranial solid tumor of the nervous system occurring predominantly in infants and children younger than five years of age. Neuroblastoma presents a challenge to therapy primarily due to a decreased responsiveness to anticancer agents like cisplatin (CDDP), leading to recurrence. Vitamin A and its derivatives, known as retinoids, are preventive against cancer and induce differentiation in some cell lines. Retinoids are now being tested clinically for the treatment of neuroblastoma. One major limitation to retinoid therapy is the development of chemoresistance. In the present study human SK-N-SH neuroblastoma cells pretreated with 10 μM all-trans retinoic acid (ATRA) for 24 h followed by CDDP (0.5 - 25 μM), exhibited a decrease in caspase-3 proteolysis and activity (24, 48, 72 and 96 h posttreatment). In order to elucidate the mechanism of retinoid-mediated resistance we analyzed levels of proteins regulated by nuclear factor kappa binding protein (NFκB) involved in intrinsic

Purpose: : To analyze effects of Omega-3 and Omega-6 fatty acids on NFΚB, IL-6 and IL-8 production, and to test their antagonizing capacities against H2O2 stimulation of these factors in primary human TM cells. Methods: : Primary hTM cells were derived from 5 different donors and propagated in Hams F10 containing 10% FCS and 1% penicillin/streptomycin mixture to passage 5 at maximum. Treatment was performed in serum-free F10 supplemented to 50µM Omega-3 or 16µM Omega-6 for 48 hours in triplicates. A second set of hTM cells was treated analogously but additionally exposed to 300µM H2O2 for 1h to induce cellular oxidative stress. Untreated hTM cells served as controls for both approaches. The mRNA expression of Il-6, Il-8, Il-1a and ELAM-1 was analyzed by realtime-PCR. Contents of IL-6 and IL-8 in the medium were quantified by ELISA. Amounts of NFΚB were determined by a NoShift™ NFΚB Assay on nuclear protein extracts of hTM cells. Results: : Realtime PCR data indicate that Omega-6 and ...

Perform reliable qPCR with Bio-Rads pre-validated ILF3 primer pair, for the Rhesus Monkey genome. Designed for SYBR Green-based detection.