Table 2 - Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA - Volume 23, Number 3-March...

Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) and tuberculosis (TB). To better understand NTM infection and TB risk patterns in Hawaii, USA, we evaluated data on a cohort of patients in Hawaii for 2005-2013. Period prevalence of NTMPD was highest among Japanese, Chinese, and Vietnamese patients (>300/100,000 persons) and lowest among Native Hawaiians and Other Pacific Islanders (50/100,000). Japanese patients were twice as likely as all other racial/ethnic groups to have Mycobacterium abscessus isolated (adjusted odds ratio 2.0, 95% CI 1.2-3.2) but were not at increased risk for infection with other mycobacteria species. In contrast, incidence of TB was stable and was lowest among Japanese patients (no cases) and highest among Filipino, Korean, and Vietnamese patients (>50/100,000). Substantial differences exist in the epidemiology of NTMPD by race/ethnicity,

Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease - Full Text View - ClinicalTrials.gov

Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms. NTM lung disease is increasing, however, genetic susceptibility of patients with the disease have not been identified. To elucidate the genetic susceptibility of NTM lung disease, the investigators perform a genome-wide association study (GWAS) including patients with NTM lung disease and healthy controls (case : control = 1 : 3). The age-, sex-matched control group will be recruited from the Korean Healthy Twin Study ...

What can you expect with treatment for mild nontuberculous mycobacterial lung disease?

if your doctor does choose to treat it, youll take the medicine for a while. the doctor will run a sputum culture test every month or two to look for bacteria.

Mycobacterium gordonae Bojalil et al. ATCC ® 35760D-5™

Mycobacterium gordonae ATCC ® 35760D-5™ Designation: Genomic DNA from Mycobacterium gordonae strain TMC 1327 TypeStrain=False Application:

Mycobacterium gordonae Bojalil et al. ATCC ® 35760D-5™

Mycobacterium gordonae ATCC ® 35760D-5™ Designation: Genomic DNA from Mycobacterium gordonae strain TMC 1327 TypeStrain=False Application:

Primary pulmonary infection caused by Mycobacterium terrae complex. - PubMed - NCBI

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Skin infection caused by Mycobacterium szulgai after allogenic bone marrow transplantation

Infections are responsible for a large part of the morbidity and mortality after BMT because of the sustained impairment of host defenses. We report a case of cutaneous infection caused by Mycobacterium szulgai in a boy who underwent BMT with marrow from a matched unrelated donor.. ...

Endemic Contamination of Clinical Specimens by Mycobacterium gordonae : Clinical Infectious Diseases - oi

Contamination of clinical specimens by Mycobacterium gordonae is a significant endemic problem in many laboratories. To investigate this problem, 84 cases at 1 hospital were retro-spectively identified during 20 months. The overall rate of specimen contamination was 2.4%, and 72 of the contaminated specimens were respiratory. A case-control comparison showed that the risk of respiratory specimen contamination was significantly increased if the specimen was expectorated (odds ratio [OR], 3.62; 95% confidence interval [CI], 1.36-9.50) or if the patient consumed fluids within 2 days before specimen collection (OR, 8.92; 95% CI, 1.40-71.20). Cultures of tap water, ice, and iced drinking water all yielded M. gordonae at 10−2-100 cfu/mL. A culture survey of consenting patients showed contamination of 8 (24%) of 34 sputum specimens collected immediately after a tap water mouth rinse. These findings demonstrate that endemic specimen contamination arises from mycobacteria in hospital tap water and ...

Imaging in Nontuberculous Mycobacterial Lung Infections: Overview, Radiography, Computed Tomography

Nontuberculous mycobacteria (NTM) are environmental organisms that are normally found in soil and water. They have only recently been associated with disease.

Mycobacterium gordonae in the Acquired Immunodeficiency Syndrome | Annals of Internal Medicine | American College of Physicians

To the editor: We recently treated a patient with the acquired immunodeficiency syndrome and disseminated infection due to Mycobacterium gordonae. Infection with this organism has not previously been reported in association with the syndrome.. A 41-year-old man who abused intravenous drugs developed Pneumocystis carinii pneumonia in November 1981. He responded to treatment with intravenous sulfamethoxazole and trimethoprim. In July 1982 he developed esophageal candidiasis which was treated with ketoconazole. The next month, a sputum specimen showed acid-fast bacilli on stain. He was treated by his physician with isoniazid. In November 1982, because of persistent fever and weakness, a bone marrow ...

Antibiotic treatment for nontuberculous mycobacteria in people with cystic fibrosis | Cochrane

Nontuberculous mycobacteria are bacteria that are in the same family as tuberculosis and are commonly found in the soil and water. These bacteria can be found in the lungs of people with cystic fibrosis and can cause their lung function to worsen. Although there are guidelines on which antibiotics to use to treat lung infection due to these bacteria, these recommendations are not specific for people with cystic fibrosis. It is also not clear which are the most effective antibiotics. The main purpose of this review was to determine whether treatment with different antibiotic combinations for nontuberculous mycobacterial infection would improve lung function or decrease the frequency of chest infections in people with cystic fibrosis. We found one randomized controlled trial but it included both people with and without cystic fibrosis and we could not get the information specifically about individuals with cystic fibrosis so could not include the information in this review. Until the time when ...

Use of Clarithromycin and Rifabutin for the Treatment of M. Avium Complex (MAC) Lung Disease - Tabular View - ClinicalTrials.gov

Meet American Thoracic Society criteria for nontuberculous mycobacterial lung disease: two or more AFB smear positive, culture positive sputums or bronchoscopic samples and/or two or more AFB smear negative respiratory samples with moderate to heavy growth (2+-4+); abnormal CXR consistent with M. avium lung disease; absence of other potential mycobacterial or fungal lung pathogens (except for the coexistence of M. abscessus ...

Table 3 - Nontuberculous Mycobacteria Infections and Anti-Tumor Necrosis Factor-α Therapy - Volume 15, Number 10-October 2009 -...

Patients receiving anti-tumor necrosis factor-α (anti-TNF-α) therapy are at increased risk for tuberculosis and other granulomatous diseases, but little is known about illness caused by nontuberculous mycobacteria (NTM) in this setting. We reviewed the US Food and Drug Administration MedWatch database for reports of NTM disease in patients receiving anti-TNF-α therapy. Of 239 reports collected, 105 (44%) met NTM disease criteria. Median age was 62 years; the majority of patients (66, 65%) were female, and most (73, 70%) had rheumatoid arthritis. NTM infections were associated with infliximab (n = 73), etanercept (n = 25), and adalimumab (n = 7); most patients were taking prednisone (n = 68, 65%) or methotrexate (n = 58, 55%) concurrently. Mycobacteria avium (n = 52, 50%) was most commonly implicated, and 9 patients (9%) had died at the time their infections were reported. A high rate of extrapulmonary manifestations (n = 46, 44%) was also reported.

Insmed Announces Results from Phase 2 Clinical Trial for Treatment Resistant Nontuberculous Mycobacterial Lung Infections -...

Insmed Incorporated (Nasdaq GS INSM) today reported results from the Company s phase 2 clinical trial of ARIKAYCE, or liposomal amikacin for inhalation, for the

Diagnostic yield of nontuberculous mycobacteria in patients booked for endoscopy at the University Teaching Hospital, Lusaka |...

The intestinal carriage of nontuberculous mycobacteria (NTM) is associated with disease, especially in severely immunocompromised individuals. These organisms, although often considered contaminants, have been known to cause various types of illnesses. We aimed to determine the prevalence of and associated factors for NTM among patients booked for colonoscopy at the University Teaching Hospital (UTH) in Lusaka. We randomly recruited 97 patients attending routine endoscopy procedures between November 2012 and October 2013 and after consent, administered a structured questionnaire. We collected stool and intestinal lavage samples, as well as biopsy samples from the descending colon and the caecal area during the endoscopy procedure. Samples were cultured using the mycobacteria growth indicator tube (MGIT) method followed by the GenoType Mycobacterium CM/AS assay for identification of NTM. Results were expressed as means and standard deviations; proportions were expressed as percentages with corresponding

Nontuberculous Mycobacteria Clinical Care Guidelines | CF Foundation

Nontuberculous mycobacteria can cause chronic pulmonary infection or can reside in the lungs without causing progressive disease. Challenges include making decisions on when and how to initiate treatment.

Evaluation of the antibacterial effect in vitro of moxifloxacin and linezolid on nontuberculous mycobacterium

... , Lanfang Fang, Xiao Chen, Zhongkang Ji, Kaijin Xu

NonTuberculous Mycobacteria (NTM) | Lung Foundation Australia

Nontuberculous Mycobacterium (NTM) can be a serious chronic lung disease that can make patients very ill and damage their lungs. The bacteria causing NTM lung

Education on Nontuberculous Mycobacteria (NTM) - Webinars, Cases, Podcast, Updates, Conference Coverage, Article Summaries

Educational resources for physicians involved in the diagnosis and management of patients with Nontuberculous Mycobacteria (NTM).

Infectious post-LASIK crystalline keratopathy caused by nontuberculous mycobacteria [2] (multiple letters)<...

TY - JOUR. T1 - Infectious post-LASIK crystalline keratopathy caused by nontuberculous mycobacteria [2] (multiple letters). AU - Yatziv, Yossi. AU - Varssano, David. AU - Lazar, Moshe. AU - Alvarenga, Lenio. AU - De Freitas, Denise. AU - Luísa Hofling-Lima, Ana. AU - Belfort, Rubens. AU - Sampaio, Jorge. AU - Sousa, Luciene. AU - Yu, Maria. AU - Mannis, Mark. PY - 2003/3. Y1 - 2003/3. UR - http://www.scopus.com/inward/record.url?scp=0037363492&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0037363492&partnerID=8YFLogxK. M3 - Article. C2 - 12605062. AN - SCOPUS:0037363492. VL - 22. SP - 188. JO - Cornea. JF - Cornea. SN - 0277-3740. IS - 2. ER - ...

Mycobacteriology Research Center - 2017

emergence and spread of multidrug resistance. Authors: Manson, A.L., Cohen, K.A., Abeel, T., Velayati, A.A., Farnia, P., et al.. Journal : Nature Genetics. 3. Association of interferon-γ receptor-1 gene polymorphism with nontuberculous mycobacterial lung infection among Iranian patients with pulmonary disease. Authors: Farnia, P., Ghanavi, J., Saif, S., Farnia, P., Velayati, A.A.. Journal : American Journal of Tropical Medicine and Hygiene. 4. Comparison between pulmonary and extrapulmonary tuberculosis in adolescents. Authors: Lotfian, F., Lotfian, G., Bolursaz, M.R., Tabarsi, P., Velayati, A.. Journal : Archives of Pediatric Infectious Diseases. 5. Low bone mineral density and associated factors in patients with cystic fibrosis: A cross-sectional study. Authors: Nodoushan, A.J., Golzar, A., Hassanzad, M., Sayedi, S.J., Velayati, A.. Journal : International Journal of Pediatrics. 6. Bacillus Calmette-Guérin vaccine complications in Iranian children at a University Hospital. Authors: ...

The growing threat of nontuberculous mycobacteria - PrescriberPrescriber

What the patient wants to do.. Innate resistance in NTM needs to be borne in mind and needs to be separated from acquired resistance, which can be avoided through good practice, Dr Griffith explained. So, for example, when using macrolides or amikacin, companion medication capable of preventing the emergence of isolates with mutational resistance that are naturally existing must also be prescribed.. ATS/IDSA guidelines detail the treatment regimens for MAC disease.6 Dr Griffith said that following these macrolide/azalide-based regimens for nodular/bronchiectatic MAC lung disease results in favourable microbiological outcomes for most patients. The regimens do not promote macrolide resistance and intermittent regimens have been shown to be as effective as daily treatment, so three-times-weekly regimens are favoured. However, Dr Griffith wondered whether anybody actually cared about the guidelines. For example, Adjemian et al. found that among a sample of 349 physicians treating 915 patients, only ...

Water Management in Healthcare Facilities for Legionella | CDC

CDC encourages healthcare facilities included in the scope of ASHRAE Standard 188external icon (Section 5.2) to develop and implement comprehensive water management programs to reduce the risk for Legionella growth and transmission. Health departments play an important role in encouraging healthcare facilities to implement Legionnaires disease prevention strategies.. A comprehensive water management program can have additional benefits in the control of other water-related healthcare-associated infections. Water management programs should therefore be monitored for their efficacy in reducing risk for a variety of pathogens, such as gram-negative bacteria (e.g., Pseudomonas, Burkholderia, Stenotrophomonas) and nontuberculous mycobacteria.1. Under rare circumstances, certain Legionella-specific interventions may provide an environment in which these other pathogens can increase in number. For example, researchers have documented increased colonization by nontuberculous mycobacteria in building ...

US CFF and ECFS consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic...

US CFF and ECFS consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive ...

Plus it

Introduction: The epidemiology of nontuberculous mycobacteria (NTM) disease remains largely unknown in Greece.. Methods: We investigated the characteristics of patients under treatment for NTM disease for the first time in Greece, for the time period 2004-2013.. Results: Out of 58 cases (27 men and 31 women, mean age±sd: 58.93±12.55 years), one patient suffered from skin (M. marinum) and the rest form pulmonary disease. Fifty patients were of Greek origin and 8 were immigrants. M. avium complex (MAC) was the leading cause of NTM disease (35 cases, 60.34%: M. avium 16, M. intracellulare 16), M. kansasii ranked second with 8 cases (13.79%) whereas RGM presented with a relative frequency of 10.34%. The rest of NTM comprised an additional 15.53% (4 M. malmoense, 2 M. xenopi, 1 M. celatum, 1 M.lentiflavium, 1 M. marinum). Cavitation was present in 40 patients (69%) and 20 nodular bronchiectatic pattern in 18 (31%). All patients were HIV negative, 30 suffered from previously known bronchiectases, 16 ...

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Mycobacterium gordonae is often regarded as a weak pathogen that only occasionally causes overt disease. We report a case of M. gordonae infection in the facial skin, nasal mucosa, and paranasal sinus in an immunocompetent patient and review previous ...

Heater-cooler devices and NTM infections | Frankel Cardiovascular Center | Michigan Medicine

On October 13, 2016 a Centers for Disease Control (CDC) Health Advisory and Food & Drug Administration (FDA) Safety Communication announced that the Stöckert 3T heater/cooler devices by LivaNova PLC (formerly the Sorin Group) may have been contaminated with Mycobacterium chimaera (M.Chimaera), a rare type nontuberculous mycobacterium (NTM), during manufacturing.

Nontuberculous Mycobacteria-Associated Lung Disease in US Hospitals

The prevalence of pulmonary nontuberculous mycobacteria-associated lung disease has increased in select geographic areas in the US. Can you guess which ones?

mediaTUM - Medien- und Publikationsserver

Low temperature domestic washing (i.e. < 40 °C) may be regarded as low-hygienic because thermal inactivation of microorganisms does not occur. Thus other means (i.e. bleaching agents) must be considered to compensate for low temperature and to achieve hygienic effects. In this study the biocidal activity of common bleaching systems as used in heavy duty detergents was examined using standard suspension test. The bleaching agents used for the tests were perborate, percarbonate, and phthalimodoperoxocaproic acid, as bleaching activators for low temperature bleaching tetraactetylethylenediamine (TAED) and nonanoyloxybenzenesulfonate (NOBS) were used. The bactericidal, fungicidal and virucidal properties of bleaching systems in question were determined on selected microorganisms (Enterococcus faecium, Escherichia coli, Staphylococcus aureus, Mycobacterium terrae, Candida albicans, Aspergillus niger and coliphages [phix174 and MS2]). The effects of temperature, pH and presence of soil on the ...

Results from Non-Tuberculous Mycobacteria (NTM) Study Using Aradigm's Liposomal Ciprofloxacin to be Presented at the American...

OSU and Aradigm to present data that in vitro treatment of macrophages infected with M. avium and M. abscessus with Aradigms liposomal ciproflo

Bacterial infection offers Sjögren's syndrome clues - Scientific Inquirer

The results of a study presented at the Annual European Congress of Rheumatology (EULAR) 2017 have shown a link between newly-diagnosed Sjögrens syndrome (SjS) and previous infection with nontuberculous mycobacteria (NTM). However, even though an increased risk of tuberculosis (TB) has been found in patients with SjS, in this study, TB infection itself did not…

The therapeutic approach to non-t... preview & related info | Mendeley

(2010) McGrath, Anderson. Pulmonary Pharmacology & Therapeutics. Non-tuberculous mycobacteria (NTM) are a group of alcohol fast, aerobic, nonmotile bacteria that are found in the environment. Recent reports indicate that their incidence and prevalence is increas...

Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia - Danish National Research...

BACKGROUND: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described. METHODS: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics. RESULTS: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p,0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died. CONCLUSION: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to ...

Clinical relevance of non-tuberculous mycobacteria isolated from respiratory specimens: seven year experience in a UK hospital ...

The frequency of isolation of non-tuberculous mycobacteria (NTM) species from respiratory specimens is increasing, however the clinical relevance of such identifications vary by mycobacterial species and geographical location. A retrospective study of 853 NTM isolates from respiratory samples from 386 patients over seven years was performed. Clinical records and radiographic information were examined. Clinical significance was assessed by American Thoracic Society diagnostic criteria. 25% of all patients with respiratory isolates met criteria for non-tuberculous mycobacterial pulmonary disease (NTM-PD). Significant symptoms were weight loss, fever, night sweats, productive cough and haemoptysis. HIV co-infection was a significant risk factor for disease. Cavities, nodules and tree-in-bud were significant radiographic findings. Mycobacterium avium complex (MAC) were the dominant species isolated from this patient cohort. Mycobacterium abscessus (M. abscessus) was the species most likely to cause ...

Cervicofacial lymphadenitis caused by nontuberculous mycobacteria; host, environmental or bacterial factors? - Semantic Scholar

Semantic Scholar extracted view of Cervicofacial lymphadenitis caused by nontuberculous mycobacteria; host, environmental or bacterial factors? by Jakko van Ingen et al.

Prevalence of nontuberculous mycobacteria in cystic fibrosis clinics, United kingdom, 2009 : Sussex Research Online

Incidence of pulmonary infection with nontuberculous mycobacteria (NTM) is increasing among persons with cystic fibrosis (CF). We assessed prevalence and management in CF centers in the United Kingdom and found 5.0% of 3,805 adults and 3.3% of 3,317 children had recently been diagnosed with NTM. Of those, 44% of adults and 47% of children received treatment.. ...

Mycobacterium abscessus - Wikipedia

Mycobacterium abscessus complex (MABSC) is a group of rapidly growing, multidrug-resistant non-tuberculous mycobacteria (NTM) species that are common soil and water contaminants. Although M. abscessus complex most commonly cause chronic lung infection and skin and soft tissue infection (SSTI), the complex can also cause infection in almost all human organs, mostly in patients with suppressed immune systems. Amongst NTM species responsible for disease, infection caused by M. abscesses complex are more difficult to treat due to antimicrobial drug resistance. M. abscessus cells are gram-positive, nonmotile, acid-fast rods of about 1.0 - 2.5 µm long by 0.5 µm wide. They may form colonies on Löwenstein-Jensen media that appear smooth or rough, white or greyish and nonphotochromogenic. M. abscessus shows growth at 28 °C and 37 °C after 7 days but not at 43 °C. It may grow on MacConkey agar at 28 °C and even 37 °C. It shows tolerance to saline media (5% NaCl) as well as 500 mg/l hydroxylamine ...

Slowly Growing Nontuberculous Mycobacteria (NTM) - Infectious Disease Advisor

Ahn, CH, Lowell, JR, Ahn, SS, Ahn, S, Hurst, GA. "Chemotherapy for pulmonary disease due to Mycobacterium kansasii: efficacies of some individual drugs". Rev Infect Dis. vol. 3. 1981. pp. 1028-34. (An evaluation of 256 patients with pulmonary M. kansasii infection. All of the 115 patients who received treatment that included rifampin had sputum conversion within 4 months. However, for regimens that did not include rifampin, 127 (90%) of 141 had conversion (p,0.01). There were no relapses reported in those who received rifampin versus 4/59 (7%) who did not receive rifampin.). Ahn, CH, Lowell, JR, Ahn, SS, Ahn, SI, Hurst, GA. "Short-course chemotherapy for pulmonary disease caused by Mycobacterium kansasii". Am Rev Respir Dis. vol. 128. 1983. pp. 1048-50. (Forty patients with pulmonary M. kansasii were treated with rifampin, isoniazid, and ethambutol for 12 months (plus streptomycin twice weekly for the first 3 months): 1/40 (2.5%) relapsed 6 months after completion of therapy.). "First randomised ...

Nontuberculous mycobacteria in cystic fibrosis associated with allergic bronchopulmonary aspergillosis and steroid therapy |...

In the current study, six out of 139 CF patients, suffering from NTM disease, mainly due to M. abscessus, are described. It was found that ABPA and systemic steroid therapy were associated with this complication. As this is a rare condition, the series of patients with NTM reported in this study is small, and, therefore, the statistical analysis must remain weak at best. Nevertheless, it is believed that this experience underlines an important and challenging clinical aspect in CF.. NTM infection appears to be an emerging disease. A clinical microbiology laboratory in Israel reported that NTM and, in particular, the species M. chelonae (of which M. abscessus was previously considered a subspecies), M. fortuitum and M. simiae are increasing in incidence 19. During 1996-1999, 135 specimens from 9,391 patients cultured positive for NTM. Of these, five patients had M. chelonae. Between 2000 and 2003, 364 out of 9,031 patients were culture positive for NTM (p,0.0001) and, of these, 51 had M. chelonae ...

Microbiology Society Journals | Mycobacterium senuense sp. nov., a slowly growing, non-chromogenic species closely related to...

A previously undescribed, slowly growing, non-chromogenic mycobacterium, isolated from a Korean patient with a symptomatic pulmonary infection, is described as representing a novel species. Its 16S rRNA gene sequence was unique and phylogenetic analysis based on 16S rRNA gene sequences showed that this organism belonged to the Mycobacterium terrae subclade. Phenotypically, the strain was generally similar to M. terrae and Mycobacterium nonchromogenicum, but its growth rate was slower than those of other M. terrae complex strains. A unique mycolic acid profile and phylogenetic analysis based on two different alternative chronometer molecules, hsp65 and rpoB, confirm the taxonomic status of this strain as a representative of a novel species. The name Mycobacterium senuense sp. nov. is proposed, with the type strain 05-832T (=DSM 44999T =KCTC 19147T).

Infección pulmonar por Mycobacterium kansasii y carcinoma broncopulmonar sincrónico

SANCHO CHINESTA, J. y CARRION VALERO, F.. Lung infection for Mycobacterium kansaii and carcinoma of the lung synchronous. An. Med. Interna (Madrid) [online]. 2002, vol.19, n.4, pp.38-40. ISSN 0212-7199.. The association of lung tuberculosis and carcinoma of the lung is very well-known, although it is exceptional the synchronous presentation of lung infection for nontuberculous mycobacteria and lung carcinoma. We present the case of a 41 yearold male, smoker, with antecedents of lung tuberculosis in the adolescence and chronic liver disease for virus B and C that he presents fever, hoarseness and loss of 4 kg of weight of a month of evolution. The CT scan of the chest revealed a lung mass in left apex with pneumonitis, tumor invading chest wall and mediastinal lymph node enlargement. The biopsy of a supraclavicular node showed metastasisof squamous carcinoma, while in the sputum was isolated Mycobacterium kansasii seneitive to rifampin and ethambutol. HIV was negative. The possible mechanisms of ...

Evaluation of RGM Medium for Isolation of Nontuberculous Mycobacteria from Respiratory Samples from Patients with Cystic...

Specific species of NTM such as MABSC organisms are considered significant CF pathogens and are associated with poorer clinical outcomes (14). The isolation of NTM from respiratory samples of CF patients is challenging because of bacterial and fungal overgrowth in AFB cultures. RGM medium, a novel selective medium designed for the isolation of MABSC organisms, has been shown to have promise for the isolation of rapidly growing mycobacteria from the sputa of CF patients (11-13). We are the first U.S. center to evaluate this medium with the largest number of samples to date. Extending the incubation time of RGM medium from 10 to 28 days and comparison between RGM medium and 8-week AFBC using an MGIT and LJ medium were intended to give a preliminary assessment of the ability to detect slowly growing mycobacteria on this medium.. RGM medium is superior to BCSA for the recovery of rapidly growing mycobacteria, with a sensitivity for the detection of NTM on RGM medium of 96.9%, compared with 35.7% on ...

Heart Surgery Nontuberculous Mycobacteria Infection Recall in Lenoir City TN

888-609-0242 Worried you or a loved one developed an NTM Infection after Heart Surgery in Lenoir City TN? Call us anytime 24/7 for a Free Case Evaluation... No Fee Unless You Win!

Heart Surgery Nontuberculous Mycobacteria Infection Recall in Dunkirk OH

888-609-0242 Worried you or a loved one developed an NTM Infection after Heart Surgery in Dunkirk OH? Call us anytime 24/7 for a Free Case Evaluation... No Fee Unless You Win!

Mycobacterium fortuitum - Wikipedia

Mycobacterium fortuitum is a nontuberculous species of the phylum actinobacteria (Gram-positive bacteria with high guanine and cytosine content, one of the dominant phyla of all bacteria), belonging to the genus mycobacterium. Mycobacterium fortuitum is a fast-growing species that can cause infections. The term "fast growing" is a reference to a growth rate of 3 or 4 days, when compared to other Mycobacteria that may take weeks to grow out on laboratory media. Pulmonary infections of M. fortuitum are uncommon, but Mycobacterium fortuitum can cause local skin disease, osteomyelitis (inflammation of the bone), joint infections and infections of the eye after trauma. Mycobacterium fortuitum has a worldwide distribution and can be found in natural and processed water, sewage, and dirt. Bacteria classified as Mycobacteria, include the causative agents for tuberculosis and leprosy. Mycobacteria are sometimes referred to as "acid-fast bacteria," a term referencing their response to a laboratory ...

Mycobacterium Fortuitum disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

NIH Rare Diseases : 50 mycobacterium fortuitum is a bacteria that can cause infections of many areas of the body including the skin, lymph nodes, and joints. it belongs to a group of bacteria, known as nontuberculous mycobacterium, as it is different from the mycobacterium that causes tuberculosis. it can be found in natural and processed water, sewage, and dirt. healthy people usually do not get mycobacterium fortuitum infections; however, they may occur after surgery, in people with an impaired immune system, or after exposure to a contaminated medical device (such as an endoscope). it is uncommon for this condition to cause lung disease, but mycobacterium fortuitum infection can lead to skin disease, osteomyelitis (inflammation of the bone), joint infections, and eye disease. the signs and symptoms of infection differ depending on the infection site. treatment also depends on the site of the infection, but usually includes prolonged use of antibiotics. last updated: 2/22/2017 ...

Nontuberculous Mycobacterial Infections - Infectious Diseases - MSD Manual Professional Edition

Nontuberculous Mycobacterial Infections - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.

Nontuberculous Mycobacteria (NTM): Properties, Pathogenic genera and their diseases - microbeonline

Mycobacterium avium-intracellularae complex (MAC): Nonphotochromogens These Non Tuberculous Mycobacteria (NTM) are classified as Nonphotochromogens in Runyon classification. M avium complex were first recognized as human pathogens in 1990s. They are the important pathogen in immunocompromised and immunocompetent populations.. They are ubiquitous in the environmental sources including natural waters; soil etc. Taxonomically, the M. avium-intracellularae complex comprises M. avium, M. intracellularae, M. paratuberculosis, M. lepraemurium and the "wood pigeon" bacillus.. These organisms causes opportunistic infections in the immunocompromised patients such as individuals infected with HIV. The lungs are primarily affected, but infection can spread to other organs as well. Disseminated disease is seen in case of AIDS patient.. Mycobacterium fortuitum complex (Rapid growers). It is a group of free living; rapid growing NTM. The colonies of these organisms appear on solid media in 7 days or less. ...

Nontuberculous Mycobacterial Infections | Harrison's Principles of Internal Medicine, 19e | AccessMedicine | McGraw-Hill Medical

In the United States, the incidence and prevalence of pulmonary infection with NTM, mostly in association with bronchiectasis (Chap. 312), have for many years been several-fold higher than the corresponding figures for tuberculosis, and rates of the former are increasing among the elderly. Among patients with cystic fibrosis, who often have bronchiectasis, rates of clinical infection with NTM range from 3% to 15%, with even higher rates among older patients. Although NTM may be recovered from the sputa of many individuals, it is critical to differentiate active disease from commensal harboring of the organisms. A scheme to help with the proper diagnosis of pulmonary infection caused by NTM has been developed by the American Thoracic Society and is widely used. The bulk of nontuberculous mycobacterial disease in North America is due to M. kansasii, organisms of the M. avium complex (MAC), and M. abscessus. ...

Random amplified polymorphic DNA genotyping of Mycobacterium malmoense. | Journal of Clinical Microbiology

The suitability of random amplified polymorphic DNA-PCR for the detection of differences between Mycobacterium malmoense strains was evaluated. With two of the 32 tested primers seven fingerprint patterns which proved excellent in distinguishing intraspecies variations of M. malmoense were obtained. The combination of the results obtained with the two primers permitted a clear separation of the strains. This technique is useful for analyzing species whose DNA sequences are not known. It can easily be adapted to test any mycobacterial species. ...

Mycobacterium Xenopi Clinical Presentation: History, Physical, Causes

Researchers first described Mycobacterium xenopi in 1959 after isolating it from skin lesions of the South African toad Xenopus laevis. M xenopi, a slow-growing, nontuberculous mycobacterium, is often considered to be a saprophyte or an environmental contaminant.

Detection of clinically important non tuberculous mycobacteria (NTM) from pulmonary samples through one-step multiplex PCR...

The burden of non-tuberculous mycobacterial (NTM) disease is increasing worldwide but still its diagnosis is delayed and it is mistaken as multidrug-resistant tuberculosis (MDR-TB).The present study was performed to develop a multiplex PCR assay for detection and identification of clinically most common NTM to the species level from pulmonary samples. Out of 50 isolates, 26 were identified as Mycobacterium kansasii (MK), 20 were identified as Mycobacterium abscessus (MA) and 4 were identified as Mycobacterium avium complex (MAC) through multiplex PCR and further confirmed by sequencing. Our study showed that multiplex PCR assay is a simple, convenient, and reliable technique for detection and differential identification of major NTM species.

Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease

The incidence of pulmonary non-tuberculous mycobacteria (NTM) disease in otherwise healthy adults is increasing as the population ages. The organisms are ubiquitous so susceptibility probably reflects a deficiency in a protective immune response. Here we investigate if singlenucleotide polymorphisms (SNP) affecting cytokines, chemokines and their receptors associate with pulmonary NTM disease. Samples from NTM patients (n=79) and healthy controls (n=188) were genotyped using TaqMan probes. Of the 16 SNPs assessed, IL28B-rs8099917*TG (rs8099917; P=0.01, OR=2.2), TNFA-1031*CC (rs1799964; p=0.02, OR=0.48) and IL10-1082*AA (rs1800896; P=0.001, OR=0.33) were significantly associated with NTM disease. IL28B-rs8099917 and IL10-1082 have been associated with perturbations of the Th1/Th2 balance, whilst TNFA-1031*CC associates with sensory neuropathy in HIV patients. IL10-1082 warrants further investigation because we observed high production of IL-10 in blood mononuclear cells from NTM patients. © 2013 ...

Virulent Mycobacterium fortuitum restricts NO production by a gamma interferon-activated J774 cell line and phagosome-lysosome...

The virulence of different isolates of Mycobacterium has been associated with two morphologically distinguishable colonial variants: opaque (SmOp) and transparent (SmTr). in this report we used an in vitro assay to compare macrophage (Mphi) responses to SmOp and SmTr Mycobacterium fortuitum variants, taking advantage of the fact that these variants were derived from the same isolate. Cells preactivated or not with gamma interferon (IFN-gamma) were infected with SmOp or SmTr M. fortuitum. We showed that SmOp and SmTr induced different levels of nitric oxide (NO) production by IFN-gamma-stimulated Mphi. Indeed, the amount of IFN-gamma-induced NO production by J774 cells was 4.8 to 9.0 times higher by SmOp (23.1 to 37.7 muM) compared to SmTr infection (3.9 to 4.8 muM) (P = 0.0332), indicating that virulent SmTr bacilli restricted NO production. in addition, IFN-gamma-induced NO production by Mphi was higher when correlated with reduction of only avirulent SmOp bacillus viability. SNAP ...

Clarithromycin vs ciprofloxacin as adjuncts to rifampicin and ethambutol in treating opportunist mycobacterial lung diseases...

The Research Committee is grateful to the following physicians and their staff, without whose cooperation the study would not have been possible: Dr R M Abbasi, Bishop Auckland; Dr O Afolabi, N Tyneside; Dr A Alexander, Bath; Dr N Ali, Sutton in Ashfield; Dr M B Allen, Stoke on Trent; Dr G Anderson, Newport; Dr P B Anderson, Sheffield; Dr S Ansari, Southend; Dr J T Baker, Wrexham; Dr V P Balagopal, Walsall; Dr J Banks, Swansea; Dr R Banks, Tonbridge Wells; Dr J Barclay, Oldham; Dr A Bartoloni, Italy; Dr J R M Bateman, Derby; Dr M Benson, Oxford; Dr A M Bentley, Manchester; Dr R J Bibby, Blackpool; Dr D Boldy, Boston; Dr M Bone, Dudley; Dr J Bradley, Barnet; Dr R A L Brewis, Newcastle; Dr M Britton, Ashford; Dr P Brown, Perth; Dr A L Burton, Preston; Dr I A Campbell, Penarth; Dr S Cardellichio, Italy; Dr J Catterall, Bristol; Dr G Chappell, Bridgend; Dr D Chew, Chesterfield; Dr J Choo Kang, Kirkcaldy; Dr R Clark, Portsmouth; Dr C J Clarke, Glasgow; Dr D Clifton, Barnsely; Dr K Connolly, ...

Mycobacterium fortuitum | Johns Hopkins ABX Guide

Mycobacterium fortuitum answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.

Sulfonamide activity against Mycobacterium fortuitum and Mycobacterium chelonei. - PubMed - NCBI

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Mycobacterium Kansasii - POZ

Mycobacterium kansasii is a type of bacterial infection that can cause life-threatening symptoms in people who have compromised immune systems.

Differentiation of M. scrofulaceum from Related Mycobacterial Species by Double-Diffusion Technique - Iranian Biomedical...

Isolation and differentiation of various species of mycobacteria are predominantly based on conventional, cultural and biochemical tests. Among the non-tuberculous mycobacteria, these tests are unable to differentiate M. scrofulaceum from M. avium-intracellulare (MAI) because of their identical biochemical characteristics. For this reason, one hundred mycobacterial strains suspected to be M. ...

Mycobacterium chimaera Outbreak Associated With Heater-Cooler Devices: Piecing the Puzzle Together

When 2 patients with disseminated M. chimaera infection following prosthetic valve surgery were detected at the University Hospital of Zurich in 2011, the implications of these findings were not immediately clear. 1 Mycobacterium chimaera is a slow-growing, nontuberculous mycobacterium (NTM) included in the M. avium complex (MAC). These opportunistic human pathogens are known to cause lung infections in those with underlying lung disease and disseminated infection in severely immunocompromised patients only. 2 Randomly amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) was performed to determine the clonal relationship of the 2 M. chimaera isolates. In contrast to the diversity seen among pulmonary M. chimaera isolates, these 2 isolates had identical RAPD-PCR patterns. 1 The hospital water system was investigated as a possible source, and M. chimaera was identified in the water circuitry of HCDs. 3 HCDs are stand-alone devices responsible for heat exchange in cardiopulmonary bypass ...

Increased risk of mycobacterial infections associated with anti-rheumatic medications | Thorax

Measurements and main results Among 56 269 older adults with RA, we identified 37 cases of TB and 211 cases of NTM disease; each case was matched to up to 10 controls. Individuals with TB or NTM disease were both more likely to be using anti-TNF therapy (compared with non-use); adjusted ORs (95% CIs) were 5.04 (1.27 to 20.0) and 2.19 (1.10 to 4.37), respectively. Exposure to leflunomide and other anti-rheumatic drugs with high immunosuppressing potential also were associated with both TB and NTM disease, while oral corticosteroids and hydroxychloroquine were associated with NTM disease.. ...

Non-tuberculous mycobacteria have diverse effects on BCG efficacy against Mycobacterium tuberculosis - The Jenner Institute

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Most recent papers with the keyword bronchiectasis guidelines | Read by QxMD

Severe alpha-1 antitrypsin (AAT) deficiency is one of the most common serious genetic diseases in adults of European descent. Individuals with AAT deficiency have a greatly increased risk for emphysema and liver disease. Other manifestations include bronchiectasis, necrotizing panniculitis and granulomatosis with polyangiitis. Despite the frequency and potential severity, AAT deficiency remains under-recognized, and there is often a delay in diagnosis. This review will focus on three recent updates that should serve to encourage testing and diagnosis of AAT deficiency: first, the publication of a randomized clinical trial demonstrating the efficacy of intravenous augmentation therapy in slowing the progression of emphysema in AAT deficiency; second, the mounting evidence showing an increased risk of lung disease in heterozygous PI MZ genotype carriers; last, the recent publication of a clinical practice guideline, outlining diagnosis and management ...

Welcome to CDC stacks | Mycobacterium heckeshornense Infection in HIV-infected Patient - 18057 | Emerging Infectious Diseases

Data on nontuberculous mycobacterial (NTM) disease in sub-Saharan Africa are limited. During 2006-2008, we identified 3 HIV-infected patients in northern Tanzania who had invasive NTM; 2 were infected with "Mycobacterium sherrisii" and 1 with M. aviu ...

JCI - Volume 115, Issue 9

Genetic defects in the IFN-γ response pathway cause unique susceptibility to intracellular pathogens, particularly mycobacteria, but are rare and do not explain mycobacterial disease in the majority of affected patients. We postulated that acquired defects in macrophage activation by IFN-γ may cause a similar immunological phenotype and thus explain the occurrence of disseminated intracellular infections in some patients without identifiable immune deficiency. Macrophage activation in response to IFN-γ and IFN-γ production were studied in whole blood and PBMCs of 3 patients with severe, unexplained nontuberculous mycobacterial infection. In all 3 patients, IFN-γ was undetectable following mitogen stimulation of whole blood, but significant quantities were detectable in the supernatants of PBMCs when stimulated in the absence of the patients own plasma. The patients plasma inhibited the ability of IFN-γ to increase production of TNF-α by both autologous and normal donor PBMCs, and ...

Lothian Weather Advisories - Weather Warnings & Watches for Lothian, MD

AccuWeather.com offers weather advisories for local cities including this Lothian Weather Advisories page for weather warnings and watches in Lothian, MD

Pulmonary Mycobacterium kansasii... preview & related info | Mendeley

(2014) Min, Amlani. Case Reports in Pulmonology. A 66-year-old male presented with chest pain, malaise, generalized weakness, and weight loss. He had been receiving etanercept injection for rheumatoid arthritis. Chest X-ray revealed a right upper lobe mass. Chest computed tomography (CT) showed ...

Analogs of RGDVY and GRGD peptides inhibit Mycobacterium kansasii phagocytosis. | Sigma-Aldrich

Sigma-Aldrich offers abstracts and full-text articles by [Ignacy Z Siemion, Monika Gawlowska, Krzysztof Krajewski, Iwona Strug, Zbigniew Wieczorek].

Macrolide-belong to the polyketide class of natural products

Macrolide-They are useful in treating respiratory, skin, soft tissue, sexually transmitted, H. pylori and atypical mycobacterial infections.

cystic fibrosis

An adult male with cystic fibrosis (CF) presents with a chronically damaged left upper lung lobe that Dr. Christopher Morse decides to treat with an open lobectomy given that the patient was not going to heal from antibiotic therapy and still had mild preserved pulmonary function. Two unusual things in this procedure are the dense inflammatory changes at the hilum and the use of muscle from chest wall to reinforce the bronchial closure because of the patients recurrent and chronic pulmonary infections due to CF ...

More than a third of heater-cooler devices used in open heart surgery may be contaminated with deadly bacteria

Heater-cooler departments (HCUs) chiefly the temperature of a spiriteds blood and agents during callousness detour surgery. The U.S. Aliment and Sedate Regulation (FDA) and the Centers for Malady Curb and Obviation (CDC) beforehand comprise subjected sanctuary threats that a materially used disgrace of HCUs potency be poisoned during putting out, a notch valetudinarians at gamble for life-threatening infections. Swop 60 percent of magnanimity ignore standard handling procedures conducted in the U.S. use the brand designation of device associated with these infections.. The dig into, distributed by John Rihs, VP of Laboratory Servings at Good Pathogens Laboratory, forward awareness around the scale of colonization of M. chimaera that might be present in these portions. Rihs and colleagues assessed maneuvers already in use for the cool-headedness of non-tuberculous mycobacteria (NTM) colonization (ab initio M. chimaera) in HCUs in mien of and after decontamination. A figure out of 653 sea top ...

MELDAP - Midlothian and East Lothian Drug and Alcohol Partnership | MELDAP - Midlothian and East Lothian Drug and Alcohol...

MELDAP is a partnership to raise awareness of the work that is being done to reduce the harm caused to individuals, families and communities by the misuse of alcohol and drugs.

Constructive dismissal and the West Lothian question: Aberdeen City Council v McNeill - LSE Research Online

Collins, Hugh (2011) Constructive dismissal and the West Lothian question: Aberdeen City Council v McNeill. Industrial Law Journal, 40 (4). pp. 439-450. ISSN 0305-9332 ...

Pyogenic spinal osteomyelitis: a review of 61 cases. - MyScien...

Pyogenic spinal osteomyelitis: a review of 61 cases.: The presentation and outcome of 61 cases of nontuberculous spinal osteomyelitis were reviewed. Although th

Pupils celebrate the best year yet as West Lothian bucks the national exam trend - Daily Record

Record breaking exam results in the county as thousands of pupils rack up Higher passes while their peers in other council areas see attainment drop.

Giving Birth With Confidence (Official Lamaze Guide, 3rd Edition) by Judith Lothian | Hachette Book Group

For a Safe and Healthy Birth… Your Way! Giving Birth with Confidence will help take the mystery out of having a baby and help you better understand how your body works during pregnancy and childbirth, giving you the confidence to make decisions that best ensure the safety and health of you and your baby ...

Treatment

CDC: Treatment of infections due to M. abscessus consists of draining collections of pus or removing the infected tissue and administering the appropriate combination of antibiotics for a prolonged period of time.