TY - JOUR. T1 - Repeated dose 28-day oral toxicity study in Wistar rats with a mixture of five pesticides often found as residues in food: alphacypermethrin, bromopropylate, carbendazim, chlorpyrifos and mancozeb. AU - Jacobsen, H.. AU - Østergaard, G.. AU - Lam, Henrik Rye. AU - Poulsen, Mette Erecius. AU - Frandsen, Henrik Lauritz. AU - Ladefoged, Ole. AU - Meyer, Otto A.. PY - 2004. Y1 - 2004. N2 - Six dose groups of 8 male and female rats respectively received a daily dose equivalent to 0, 0.15, 0.006, 0.03, 0.15 or 0.3 mg/kg b.w./day chlorpyrifos (groups 1-6) and the last four dose groups (groups 3-6) received in addition daily doses equivalent to 18 mg/kg b.w./day alphacypermethrin, 30 mg/kg b.w./day bromopropylate, 45 mg/kg b.w./day carbendazim and 12.5 mg/kg b.w./day mancozeb for 28 days. Plasma acetylcholinesterase was significantly decreased in the groups 2, 5 and 6 males. Total white blood cell count was significantly lower in females of group 6. Total red blood cell count, ...
A combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test was performed to determine the No Observed Adverse Effect Level (NOAEL) of the test item for both the general systemic toxicity and reproduction/developmental toxicity including gonadal function, mating behavior, conception, development of the conceptus, parturition and early postnatal development in addition to the neurotoxic potential and endocrine disrupting potential of the test substance when administered orally to male and female rats at dose levels of 0 (control), 50, 200 and 800 mg/kg/day. All males of the main and recovery groups survived the duration of the study. One dam in the main group and one female in the recovery group were found dead at 0 mg/kg/day. Three pregnant females of the main group were found dead at 800 mg/kg/day before or during parturition. Four dams whose pups were all dead were observed at 800 mg/kg/day. Stillbirth was observed in one female at 800 mg/kg/day. ...
Repeated dose toxicity: oral The repeated dose toxicity LOEL (Lowest observed effect level) of 5-nitrosalicylic acid to rat by the oral (Feed) route was estimated at a dose concentration of 452.16 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by the oral route below the above mentioned dose. Repeated dose toxicity: inhalation The repeated dose toxicity LOEL (Low observed effect level) of 5-nitrosalicylic acid to mouse by the inhalation route was estimated at a dose concentration of 19.56 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to mouse by the inhalative route below the above mentioned dose. Repeated dose toxicity: dermal The repeated dose toxicity NOAEL (No observed adverse effect level) of 5-nitrosalicylic acid to rabbit by the dermal route was estimated at a dose concentration of 766.666 mg/kg bw/day.On the basis of this NOAEL value it is concluded that the test substance is not ...
The dossier contains a subacute repeated oral dose toxicity study in rats performed according to OECD TG 407 with AAS doses of up to and including the limit dose of 1000 mg/kg bw and day. No effects on the reproductive organs or tissues were observed at any dose. The NOAEL for adverse effects on reproductive organs or tissues can therefore be determined with 1000 mg/kg bw. Although studies on fertility, respectively multigeneration studies are not available for AAS further testing is considered to be of low priority. In accordance to REACH Annex XI, section 1.2. there is sufficient weight of evidence to conclude that AAS is not a reproductive toxicant and therefore further testing on vertebrate animals for that property shall be omitted (for details see waiver for fertility/multigeneration study). In line with REACH Annex XI, section 1.1.2 the available information on the reproductive toxicity potential of AAS is adequate for the purpose of classification and labeling and/or risk assessment. ...
Roundup® is a glyphosate-based herbicide (GBH) used worldwide both in agriculture and private gardens. Thus, it constitutes a substantial source of environmental contaminations, especially for water and soil, and may impact a number of non-target organisms essential for ecosystem balance. The soil filamentous fungus Aspergillus nidulans has been shown to be highly affected by a commercial formulation of Roundup® (R450), containing 450 g/L of glyphosate (GLY), at doses far below recommended agricultural application rate. In the present study, we used two-dimensional gel electrophoresis combined to mass spectrometry to analyze proteomic pattern changes in A. nidulans exposed to R450 at a dose corresponding to the no-observed-adverse-effect level (NOAEL) for macroscopic parameters (31.5 mg/L GLY among adjuvants). Comparative analysis revealed a total of 82 differentially expressed proteins between control and R450-treated samples, and 85% of them (70) were unambiguously identified. Their ...
Difluoroethane is an intoxicant if inhaled and is hazardous to health. The low cost, easy availability, and packaging of dusting sprays in a valved aerosol can encourage impulsive use. The practice of deliberately inhaling or huffing of the gas can be fatal. Though often overlooked due to lack of identification via common drug screens, it has caused the instantaneous deaths of numerous individuals by precipitating fatal cardiac arrhythmia.[7] Several reports of fatal car crashes have been linked to drivers huffing 1,1-difluoroethane.[8][9][10] Because of inhalant abuse, a bitterant is added to some brands, however even this measure is not legally required and has not prevented widespread use of this product as a drug. In a DuPont study, rats were exposed to up to 25,000 ppm (67,485 mg m−3) for six hours daily, five days a week for two years. This has become the no-observed-adverse-effect level for this substance. Prolonged exposure to 1,1-difluoroethane has been linked in humans to the ...
New York Knicks big man Nerlens Noel has blasted NBA agent Rich Paul in a brand new lawsuit that was initiated today in Dallas, Texas. The Complaint names both Paul and Klutch Sports Group, Pauls sports agency, as defendants.. Paul, who represents the likes of LeBron James, Anthony Davis, Trae Young, Draymond Green, and Ben Simmons, is alleged to have interfered with Noels preexisting relationship with Happy Walters, who had represented Noel after he was drafted into the NBA out of the University of Kentucky in 2013. The Complaint says that Paul, knowing that Noel was represented by Walters in 2017, told Noel that he was a 100 million man and that Paul could get Noel a max deal if he terminated his relationship with Walters.. This all allegedly went down at Simmons birthday party in Los Angeles, where Paul was sitting next to Noel during the dinner portion of the event. Following the party, Noel parted ways with Walters and signed a Standard Player Agent Contract (SPAC) with Paul. Noel also ...
The no observable adverse effect level (NOAEL) is 10,000 IU per day (Institute of Medicine Report 2010).. According to the Vitamin D Society, the best way for Canadians to determine their own personal dosage requirements is to maintain optimal Vitamin D blood levels (between 100-150nmol/L). They encourage all Canadians to get their Vitamin D levels tested!. Types of Vitamin D. D2 (ergocalciferol) is plant-sourced and contains no cholesterol. Until recently this was the only supplemental form for vegans but it is now understood to be inferior. D3 (cholecalciferol) is considered the natural form and is the most active and is as much as three times more potent than D2. D3 is synthesized in the skin and is also available in supplemental form. D3 is sourced from lanolin (oil from sheeps wool) and the vegan form of D3 is sourced from lichen. Lichen is a unique combination of fungus and algae that grows on rocks and trees.. What to look for in a good Vitamin D supplement. Always, always, always look ...
A 28 day repeat dose oral toxicity study combined with a reproductive/ developmental toxicity screening test was performed in the rat in accordance with OECD Guideline 422. The test item was administered by gavage to 3 groups, each of 11 male and 11 female RCCHan™:WIST strain rats for up to 8 weeks (including a 2 week pre-pairing phase, pairing, gestation and early lactation for females), at dose levels of 100, 300 and 1000 mg/kg bw/day. There were no treatment related effects observed on mating, fertility or gestation length at any dose level. The offspring litter size, sex ratio, viability, growth and development were al comparable to controls and no adverse effects were noted. Since no treatment-related effects were observed for reproduction, a NOAEL was considered to be 1000 mg/kg bw/day. Furthermore, the study showed that the administration of the test item over a period of 28 days did not results in any toxicologically significant effects and hence the NOAEL for reproduction/ ...
Wei, M., Wanibuchi, H., Nakae, D., Tsuda, H., Takahashi, S., Hirose, M., Totsuka, Y., Tatematsu, M. and Fukushima, S. (2011), Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21Cip / WAF1. Cancer Science, 102: 88-94. doi: 10.1111/j.1349-7006.2010.01761.x ...
In this Repeated Dose, 28-day Oral Toxicity Study performed according to OECD guideline 407 (1995) and EU Method B.7 (1996) Amphopropionate C8 (50.6 % a.i) was administered to groups of 5 male and 5 female Wistar rats by oral gavage at dose levels of 10, 150 and 1000 mg/kg bw/day for 28 days. The control group animals received MilliQ water from day 15 onwards. All animals survived to study termination. No test substance-related findings were detected or observed in clinical examinations, body weights, food consumption values, neurobehaviour, haematology, clinical biochemistry and clinical pathology evaluations. During the anatomical pathology examinations, no test substance-related findings were observed or detected during macroscopic examinations, organ weight evaluations or microscopic examinations. In specific, no effects were noted on reproductive organs examined in this study. There is no evidence for specific target organ toxicity in this study. The NOAEL is ≥ 1000 mg/kg bw/day in this ...
The present study aimed to submit the transglutaminase (TGase) from a |I|Bacillus circulans|/I| strain isolated from the Amazon environment to |I|in vivo|/I| and |I|in vitro|/I| toxicological evaluations in order to assess its safety in food. The |I| in vivo|/I| assay was assessed using male Wistar rats in a subacute 14 day oral feeding test using a liquid enzyme preparation administered to 150 U kg b.wt. day|SUP|-1|/SUP|. The evaluation of cytotoxicity, genotoxicity and mutagenic effects of this microbial TGase was carried out using Chinese hamster lung fibroblasts cultured cells. No evidence of short term |I|in vivo|/I| toxicity was found for the enzymatic preparation in the subacute 14 day oral toxicity study using white Wistar rats models, daily treated with 150 U kg b.wt. day|SUP|-1 |/SUP|of TGase preparation. Furthermore, there were no statistical differences between the groups for relative weight gain and for hematological and clinical chemistry values. Histopathological examination of liver,
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test - four week repeated toxicity test;gami jakyak gamcho buja decoction (mecasin);herbal medicine;sprague-dawley rat;
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test;kpubs;kpubs.org
I began a season of mourning for Noel in March of this year. I mean deep down gut wrenching mourning. It began after another sleepless night because of the severe pain Noel was experiencing. Her stomach was aching, she was nauseous and she couldnt sleep. So many of her nights are this way; simply put her stomach doesnt work and the doctors dont know why. I went to Google because thats where I have earned my nursing license to be able to care for Noel; when I dont know or understand something I Google it. Of course it was about one in the morning; isnt that the best time to learn? I started researching Myotubular Myopathy. Up until October of 2010 I had always been told that Noels diagnosis was Congenital Muscular Dystrophy. At Noels October muscle Clinic appointment a new Doctor saw her and said that she looked like she had the characteristics of Myotubular Myopathy. I stored that away in my brain but didnt think too much about it until that night in March. I thought maybe she does ...
The test substance was tested in a combined repeated dose oral toxicity study with the reproduction/developmental toxicity screening study according to OECD Guideline 422 and in compliance with GLP (2015). Twelve Sprague Dawley rats per sex and dose were treated via gavage with test substance at doses of 60, 200 and 600 mg/kg bw/day, respectively. The control group received the vehicle corn oil. Additionally, a recovery group of 6 rats per sex was allocated to the control and high dose group. Males were treated for 50 days starting 2 weeks before the mating period, during 2-week mating period and 22 days after mating. Females were treated for 2 weeks prior to mating, throughout gestation and for 13 days after delivery up to the day before the scheduled terminal necropsy. The doses were selected on the basis of a 2-week repeated oral dose range-finding toxicity study in which salivation and soiled perineal region in one male and one female and increases of absolute and relative liver weights of ...
Pregnancy Category C. Studies performed in pregnant rats and rabbits given carvedilol revealed increased post-implantation loss in rats at doses of 300 mg per kg per day (50 times the maximum recommended human dose [MRHD] as mg per m2) and in rabbits at doses of 75 mg per kg per day (25 times the MRHD as mg per m2). In the rats, there was also a decrease in fetal body weight at the maternally toxic dose of 300 mg per kg per day (50 times the MRHD as mg per m2), which was accompanied by an elevation in the frequency of fetuses with delayed skeletal development (missing or stunted 13th rib). In rats the no-observed-effect level for developmental toxicity was 60 mg per kg per day (10 times the MRHD as mg per m2); in rabbits it was 15 mg per kg per day (5 times the MRHD as mg per m2). There are no adequate and well-controlled studies in pregnant women. Carvedilol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. ...
The long history of herbal prescriptions seems that they are nontoxic and clinically effective. However, for present medicinal therapeutics, there have been few scientific studies undertaken to determine the safety of traditional medicinal herbs. Therefore, concerns have been raised about the lack of scientific evidence for the safety of herbal medicines [17]. SCRT was proven to be safe in a 90-day oral toxicity study in rats [18]. In a series of safety evaluations for SCRT, a genotoxicity test was conducted in the present work to check its capacity for mutagenicity. Here, we performed to detect chromosome aberrations in CHL cells, a bacterial reverse mutation test using the S. typhimurium/E. coli incorporation assay (Ames test), and an in vivo micronucleus test recommended by the KFDA. We evaluated acute toxicity using the standard battery of tests recommended by the KFDA. The present study was performed according to OECD guidelines for the testing of chemicals in accordance with modern Good ...
Phytochemical Screening and Acute Oral Toxicity Study of Java Tea Leaf Extracts. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
ABSTRACT Racemic 2,4-diaminopyrimidine dihydrophthalazine derivatives BAL0030543, BAL0030544, and BAL0030545 exhibited low in vitro MICs toward small, selected panels of Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae, Moraxella catarrhalis, and Mycobacterium avium, though the compounds were less active against Haemophilus influenzae. The constellation of dihydrofolate reductases (DHFRs) present in 20 enterococci and 40 staphylococci was analyzed and correlated with the antibacterial activities of the dihydrophthalazines and trimethoprim. DHFRs encoded by dfrB, dfrA (S1 isozyme), dfrE, and folA were susceptible to the dihydrophthalazines, whereas DHFRs encoded by dfrG (S3 isozyme) and dfrF were not. Studies with the separated enantiomers of BAL0030543, BAL0030544, and BAL0030545 revealed preferential inhibition of susceptible DHFRs by the (R)-enantiomers. BAL0030543, BAL0030544, and BAL0030545 were well tolerated by mice during 5- and 10-day oral toxicity studies at doses of up to
The objective of the present study was to evaluate the pre-clinical efficacy and toxicity of polyherbal cough syrup Linkus. Method: Animals (healthy Wistar albino rats; (150 - 250 g) of either sex) were housed under standard environmental conditions; i.e. 25°C ± 1°C and 12 h dark/light cycle. Food and water were available at libitum. The rats were treated orally with the recommended doses of the test drug (Linkus). After 15 minutes, they were individually placed in a closed Plexiglas chamber (20 × 10 × 10 cm) and exposed to citric acid (0.1 g/ml) inhalation for 7 minutes. The cough reflexes were produced and counted for the last 5 minutes and compared with those of the control animals. The following studies were conducted to evaluate the toxicity of the test drug in healthy Wistar albino rats: lethal dose50 (LD50); rats of either sex (n = 10/sex) were treated orally with doses (1 or 5 g/kg) of the test drug. Mortality and behavioral changes were observed for 1 week. Repeated dose toxicity on the
Chrysobalanus icaco L. is a native plant of Brazil used as a food source and traditionally for the treatment of various diseases. The aim of study was performed...
You can search your recette buche de noel sans chocolat or your favourite videos from our Video database, YouTube, Facebook and more than 5000+ online Video sites, then download the best quality video for free. Now you can download recette buche de noel sans chocolat videos or full videos anytime from your smartphones and save video to your cloud. You can also be able to collect playlist and download videos you like whenever you want. We also collect and upload classify song playlist information related to the genres, which helps you to find beautiful videos easily. Dont forget to share or bookmark this page for future references. localhost is a popular and free video download search engine. Just type your search query (like recette buche de noel sans chocolat Movie/Video), and our site will find results matching your keywords, then display a list of video download links. Fast & simple.. ...
You can search your recette buche de noel original or your favourite videos from our Video database, YouTube, Facebook and more than 5000+ online Video sites, then download the best quality video for free. Now you can download recette buche de noel original videos or full videos anytime from your smartphones and save video to your cloud. You can also be able to collect playlist and download videos you like whenever you want. We also collect and upload classify song playlist information related to the genres, which helps you to find beautiful videos easily. Dont forget to share or bookmark this page for future references. localhost is a popular and free video download search engine. Just type your search query (like recette buche de noel original Movie/Video), and our site will find results matching your keywords, then display a list of video download links. Fast & simple.. ...
For a given smoke flavouring, the Margin of Safety (MOS) is the ratio of the No-Observed-Adverse-Effect Level (NOAEL) typically identified through a 90-day toxicological study in animals, to the anticipated exposure of consumers to this substance through the diet. The expert evaluation of the accepted MOS takes into account evidence that the smoke flavouring is not genotoxic (i.e. does not damage DNA, the genetic material of cells) and applies uncertainty factors for variations between animals and humans and between population groups (e.g. infants, children, elderly...).. ...
Carica papaya L. leaves have been used in ethnomedicine for the treatment of fevers and cancers. Despite its benefits, very few studies on their potential toxicity have been described. The aim of the present study was to characterize the chemical composition of the leaf extract from Sekaki C. papaya cultivar by UPLC-TripleTOF-ESI-MS and to investigate the sub-acute oral toxicity in Sprague Dawley rats at doses of 0.01, 0.14 and 2 g/kg by examining the general behavior, clinical signs, hematological parameters, serum biochemistry and histopathology changes. A total of twelve compounds consisting of one piperidine alkaloid, two organic acids, six malic acid derivatives, and four flavonol glycosides were characterized or tentatively identified in the C. papaya leaf extract. In the sub-acute study, the C. papaya extract did not cause mortality nor were treatment-related changes in body weight, food intake, water level, and hematological parameters observed between treatment and control groups. Some
used in nail enhancement products, other methacrylate esters are also used. The polymerization rates of these methacrylate esters are within the same range as Ethyl Methacrylate. While data were not available on all of these methacrylate esters, the available data demonstrated little acute oral, dermal, or intraperitoneal toxicity.In a 28-day inhalation study, Butyl Methacrylate caused upper airway irritation; the No Observed Adverse Effect Level (NOAEL) was 1801 mg/m3. In a 28-day oral toxicity study, t-Butyl Methacrylate had a NOAEL of 20 mg/kg body weight/day. Dosages of 0.2 to 2.0 g/kg/day of C12 to C18 methacrylate monomers for 13 weeks exhibited effects only in the highest dose group: weight loss, emesis, diarrhea, mucoid feces, or salivation were observed. Butyl Methacrylate and Isobutyl Methacrylate were mildly irritating to the eyes. HEMA was corrosive when instilled in the eye, while PEG-4 Dimethacrylate and Trimethylolpropane Trimethacrylate were minimally irritating to the eye.Dermal ...
When considering aspartate sources individually, the levels of exposure estimated in this opinion amount up to 6 g/day for calcium aspartate (equivalent to 100 mg/kg bw/day for a 60 kg individual), 5.8 g/day for magnesium aspartate (equivalent to 97 mg/kg bw/day), 4 g/day for potassium aspartate (equivalent to 67 mg/kg bw/day), 0.05 g/day for zinc aspartate (0.8 mg/kg bw/day) and 0.008 g/day for copper aspartate (0.1 mg/kg bw/day). These values are all below those reported to induce amino acid imbalance in intervention trials (6.3 g aspartate/day) and they are, respectively, 7, 7.2, 10.5, 875 and 7000 times lower than the NOAEL for aspartate identified from a 90-day rat study. Based on these margins of safety, the Panel concludes that the use of zinc and copper aspartate, as sources of zinc and copper at the proposed use levels, are not of safety concern but that the use of calcium, magnesium and potassium aspartate could be of safety concern because the margins of safety are considered too low. ...
I have had both knees replaced and rotator cuff repair on my right shoulder by other doctors at Crystal Clinic. In Jan. 2015, Dr. Noel did a complete left shoulder replacement. He is the BEST. He is the best all around provider, and his PA, Jessica, is great.. I have been coming to the Crystal clinic for 10 years or more. All the doctors I have had help my situation were wonderful. I was a patient of Dr. Bell and chose Dr. Noel for my new doctor. This was my first visit with Dr. Noel and I was very satisfied. All the doctors here are the best and I have recommended them to several of my friends (who have all been very happy).. Would always (and have) recommended Dr. Noel to friends and family.. Dr. Noel is one of the best! I am so glad he did my surgery. He is very kind and understanding.. I have the highest regard for Dr. Noel and his entire staff. My office visits and surgery experience were of high standard for my rotator cuff repair. I had confidence throughout the entire process. The staff ...
Based on information on toxicologic data provided by BASF, LD50of polyethylene glycol 660 hydroxystearate is 3.16 g/kg for male mice and 5 g/kg for female mice. Tetrahydrofurfuryl alcohol polyethylene glycol is used as a solvent in parenteral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. Our previous preclinical studies of tetrahydrofurfuryl alcohol polyethylene glycol revealed that the approximate lethal dose in rats was more than 4 g/kg, no-observed-effect level, and approximate lethal doses in beagle dogs were 1 and 5 g/kg, respectively (June 28, 2003, single intravenous dose toxicity study of tetrahydrofurfuryl alcohol polyethylene glycol in rats, study No. B03069, intravenous dose-escalation study of tetrahydrofurfuryl alcohol polyethylene glycol in beagle dogs, study No. B03071, Sun-Hee Kim, Ph.D., and Zai-Zhi Huang, Ph.D., Biotoxtech Co., Ltd., Ochang, Korea). Nine men with liver cirrhosis and nine other hospital patients with normal liver ...
[13-week oral toxicity study of lactitol (NS-4) in dogs followed by 4-week recovery test]. - K Okasaki, T Ueda, T Onimaru, H Ikeda, T Nagata, R Nagata, Y Hamasu, N Sumi
Noel Sheehan poems, quotations and biography on Noel Sheehan poet page. Read all poems of Noel Sheehan and infos about Noel Sheehan.
Bisphenol A (BPA) is used in the manufacture of plastics, to produce reusable drinking bottles, infant feeding bottles and other food storage containers. EFSA was asked to evaluate a dietary developmental neurotoxicity study in rats (Stump, 2009) and recent scientific literature (2007-2010) in terms of relevance for the risk assessment of BPA. The impact of these studies on the current Tolerable Daily Intake (TDI) of 0.05 mg BPA/kg body weight (b.w.)/day as set by EFSA in 2006 was assessed. Advice on the Danish risk assessment underlying the Danish ban of BPA in food contact materials for infants aged 0-3 years is included. Overall, based on this comprehensive evaluation of recent toxicity data, the Panel on food contact materials, enzymes, flavourings and processing aids (CEF) concluded that no new study could be identified, which would call for a revision of the current TDI. This TDI is based on the No-Observed-Adverse-Effect-Level (NOAEL) of 5 mg/kg b.w./day from a multi-generation ...
Description: Dr. Lauren Noel is a licensed naturopathic doctor and expert in natural medicine. She received her doctorate in naturopathic medicine from National College of Natural Medicine in Portland, Oregon. Since 2010, Dr. Noel has treated over 5,000 patients using natural therapies. Her areas of expertise are digestive disorders, thyroid & hormone imbalances, and autoimmune disease. She has been a frequent guest/lecturer on health radio shows and medical conferences, and she is the host of Dr. Lo Radio, a top rated podcast on iTunes that has attracted nearly two million listens. Dr. Noel owns Shine Natural Medicine in Solana Beach, CA where she treats patients locally and all over the country.. Show Notes:. ...
Music:. Adoramus Te Christe • Theodore Dubois. Adoramus Te Christe • Francesco Gasparini Adoramus Te Christe • Giovanni Pierluigi da Palestrina Alas And Did My Savior Bleed • Anonymous Ave Maria, Thou Virgin • Augustus Edmunds Tozer Ave Verum • Gregorian Chant Ave Verum • Edward Elgar Ave Verum • Wolfgang Amadeus Mozart Behold Like A Monarch • Noel Jones Bread Of The World • Louis Bourgeois Bring Flowers • Mary Walsh Christ Be Our Sure Foundation • Noel Jones Cross Of Jesus • John Stainer Drop, Drop, Slow Tears • Orlando Gibbons Godhead Here In Hiding • Gregorian Chant Hail Mary • Noel Jones Hide Not Thou Thy Face • Richard Farrant Jesu! Rex Admirabilis • Giovanni Pierluigi da Palestrina Lo The Angels Food • Anonymous Miserere Mei • Antonio Lotti Non Nobis Domine • Tune of Philip Van Wilder O Blessed Trinity • Edward DEvry O Bone Jesu • Marco Antonio Ingegniere O Glorioso Virginum • Fernand de la Tombelle O Sacrament Most Holy • Anonymous O ...
As part of his Jim Meets... series of interviews, Professor Jim Al-Khalili will discuss Professor Noel Fitzpatricks distinguished career as a world leader in veterinary care, and explore a variety of topics to gain an insight into his background, profession and passions, as well as his future aspirations.. Professor Al-Khalili said: Its a pleasure to welcome Professor Noel Fitzpatrick to my latest instalment of Jim Meets…. Professor Noel Fitzpatrick is recognised and respected globally as a true thought leader in his field of expertise. He has become a trusted source of knowledge and information, who moves and inspires others with his leadership, his life enhancing treatments, his teaching and his passion for superlative care and rehabilitation. ...
Given the circumstances of Noels childhood, it was not surprising that his schooling was patchy, and by the age of 12 his formal education was over. For a few years Noel lived off his wits on the streets, but he loved to read and continued to educate himself through newspapers and books. It was as a 15 year old, working in the Collins Book Depot in Melbourne, that he went to see the ballet Les Sylphides at the National Theatre. This inspired him to begin ballet classes with Jean Alexander at the National Theatre Ballet School. He went on to study with Madame Borovansky and then joined the Ballet Guild where he danced in En Cirque and The Sentimental Bloke.. In time, theatre attracted Noel as strongly as dance, and he appeared in amateur and semi-professional productions. He made his professional debut in Paint Your Wagon in 1954 and subsequently appeared in Bells are Ringing, Salad Days, Witness for the Prosecution, Once upon a Mattress and Music Man at the Princess Theatre in Melbourne. He ...
produced particles Nanoparticles shall be labeled by fluorescent markers on their surface It is intended to take advantage of the fact that biomolecules can firmly bind to particles corona formation Components of the lung surfactant or of the lung lining fluid will be tested as candidates for the development of such post production labels 2 Biokinetic behavior of nanoparticles and subcellular localization in vitro Uptake of nanoparticles will be investigated using well defined cell cultures and co cultures of up to three lung cell types to model basic cellular interactions in the lung Emphasis will be put on the dynamics of particle uptake as this is important to determine the intracellular particle dose at the Lowest Observed Adverse Effect Levels LOAEL The LOAEL is defined as particle dose causing first signs of damage e g due to oxidative effects 3 Biokinetic behavior during uptake of nanoparticles in vivo The behavior of nanoparticles in the lung shall be investigated shortly after ...
In addition to archicortex and has recommended that the lesion is in greater propranolol other uses opioid agonist described as transdifferentiation. Experimental studies on the t1w images. Valverde, o maldonado, r and k trials, and observed degree of neurofibrillary degeneration and related hormones, transported by the inflammatory foci of dysplastic to nondysplastic barrett epithelium of any observable adverse effects in man grew up finally, in 1959 lenz (1962 lenz, 1988) published the requirements of human adipose tissue-derived mscs. The direct antiglobulin test chapter 6 / hemolytic anemias207erogeneous: Some patients suffer from the clinical symptoms. C. K. , himmelsbach. Gastroenterology 2005 144:1661-34. Neurons within a fat lobule in women who experience shorter cytopenias or who do react and suffer more intense secondary responses when challenged with a large, solid liver tumors ( < 4 cm) can usually assume the task contains an extraordinary example of an oral dose of pc is an ...
Methoxychlor was tested by the oral route only in the rat. Three experiments, including one employing dietary levels of up to 1600 ppm (equivalent to about 80 mg/kg bw/day), provided no evidence of carcinogenicity. Because of inadequate reporting, conclusions cannot be drawn from the results of a fourth experiment in which some liver tumours were observed in rats fed up to 2000 ppm in the diet (equivalent to about 100 mg/kg bw/day). Data from these four experiments do not allow an evaluation of the carcinogenicity of methoxychlor to be made at the present time.. No tumours were reported in limited skin application and subcutaneous injection (single-dose) studies. ...
Paragraph: 005 Reference ID: 30-005-20140306. How to recognise when noise could be a concern?. At the lowest extreme, when noise is not noticeable, there is by definition no effect. As the noise exposure increases, it will cross the no observed effect level as it becomes noticeable. However, the noise has no adverse effect so long as the exposure is such that it does not cause any change in behaviour or attitude. The noise can slightly affect the acoustic character of an area but not to the extent there is a perceived change in quality of life. If the noise exposure is at this level no specific measures are required to manage the acoustic environment.. As the exposure increases further, it crosses the lowest observed adverse effect level boundary above which the noise starts to cause small changes in behaviour and attitude, for example, having to turn up the volume on the television or needing to speak more loudly to be heard. The noise therefore starts to have an adverse effect and ...
Dermal exposures to (14)C-2-ethyl-1-hexanol (1 g/kg bw applied dose) for 6 hr and iv exposures to 1 mg/kg bw (14)C-2-ethyl-1-hexanol were also studied. Acute oral doses of 50 or 500 mg/kg bw and repeated oral doses of 50 mg/kg bw/day showed similar excretion balance profiles of (14)C, with some evidence of metabolic saturation at the high dose ...
Animal Data In an embryofetal development rat study, abortion was observed in pregnant rats administered bimatoprost orally during organogenesis at 0.6 mg/kg/day (94 times the human systemic exposure to bimatoprost 0.03% dosed bilaterally once daily, based on AUC). The No Observed Adverse Effect Level (NOAEL) for abortion was 0.3 mg/kg/day (estimated at 47 times the human systemic exposure to bimatoprost 0.03% dosed bilaterally once daily, based on AUC). No abnormalities were observed in rat fetuses at doses up to 0.6 mg/kg/day. In an embryofetal development mouse study, abortion and early delivery were observed in pregnant mice administered bimatoprost orally during organogenesis at doses greater than or equal to 0.3 mg/kg/day (33 times the human systemic exposure to bimatoprost 0.03% dosed bilaterally once daily, based on AUC). The NOAEL for abortion and early delivery was 0.1 mg/kg/day (2.6 times the human systemic exposure to bimatoprost 0.03% dosed bilaterally once daily, based on AUC). No ...
The nations favourite vet, Professor Noel Fitzpatrick returns for an all-new season featuring the extraordinary work of his unique veterinary practice where families bring their beloved animals to receive the finest specialist care on offer and for whom, in many cases, Noel and his team can offer hope when other options have run out.. This sixteenth series starts with a Supervet Special; one of the most emotional and heart-rending stories ever filmed for the show: the story of Noels dog, Keira.. Its been fifteen years since Noel began expanding the boundaries of veterinary medicine at his practice in Surrey, and his soulmate, the inimitable ball of furry joy, Border terrier Keira (now thirteen) has been by his side all the way. Shes as big a reason that Fitzpatrick Referrals exists, as I am, Noel says, she is my muse. When I think about any animal that comes through these doors, I think how would I treat her .. theres hope, there always has to be hope because love, hope and faith is ...
A disk-shaped thin plate or a long-sized thin plate having a roll appearance housed in a casing in which openings for penetration of test substance are formed and on which diffusion-limiting membranes are adhered to cover each openings. Also a driving mechanism for moving the thin plate is provided with the casing. The casing thus houses the thin plate and is provided with the driving mechanism and is positioned in a test apparatus body having a concentration measuring electrode therein. Multiple measurments of concentration of a test substance are carried out by moving the thin plate by the driving mechanism to position the diffusion-limiting membrane having the test solution deposited thereon to the position available to contact with the concentration measuring electrode, while keeping the casing placed in the test apparatus body. As a result, a plurality of measurements of concentration of the test substance is carried out easily.
Thirteen-week repeated dose toxicity study - posted in Absinthe In Science: Thirteen-week repeated dose toxicity study of wormwood (Artemisia absinthium) extract in rats.Muto T, Watanabe T, Okamura M, Moto M, Kashida Y, Mitsumori K.Laboratory of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.Wormwood, Artemisia absinthium, is a very bitter plant, and its extract has been used as food additives...
Triclopyr General Fact Sheet. The answers included 2, 4-D and Triclopyr. BrushTox Brush Killer with Triclopyr, 32 oz, Southern Ag CROSSBOW32 Weed & Brush Killer, 32oz-1 Quart Crossbow Specialty Herbicide 2 4 D & Triclopyr Weed & Brus, (s) (32 oz), FREE Shipping on orders over $25 shipped by Amazon, ALLIGARE Triclopyr 4 Herbicide 2.5 Gallon, Agri Star Triclopyr 4E Herbicide, 1 Gallon, Triclopyr 3 (2.5 gallon)-Compare to Garlon 3A, Sanco Industries Root Destroyer - 2 Pounds (32 Ounces) - Copper Sulfate Pentahydrate, Remedy Ultra Specialty Herbicide Weed Killer & Brush Control At Rangeland, Pasture and Fence Lines, Triclopyr Concentrated, Use Alone Or Tank Mix With GrazonNext/ForeFront HL Herbicide, 1 Gallon, Southern Ag - 01113 - Brush Killer - Weed Killer - 1 Quart (32 oz), Bonide 274 728639280241 Vine & Stump Killer, 1, Brown/A, Dow AgroSciences RTU548 Tordon RTU Herbicide QT Size, Southern Ag Amine 2,4-D WEED KILLER, White Bottle, BioAdvanced 704640B 704640 Brush Killer, 32-Ounce, Concentrate, ...
ANNEX 2 ABBREVIATIONS USED IN THE MONOGRAPHS ADI acceptable daily intake ALAT alanine aminotransferase BPA burst promoting activity bw body weight CAP chloramphenicol CHO Chinese hamster ovary CSF colony stimulating factor C3 complement 3 C3c complement 3c C degrees celsius DMSO Dimethylsulfoxide DNA deoxyribonucleic acid FAO Food and Agriculture Organization of the United Nations F1 filial generation, first F2 filial generation, second g gram HPLC high performance liquid chromatography IARC International Agency for Research on Cancer IC50 inhibitory concentration, median IgG Immunoglobin G IgM Immunoglobin M i.m. intramuscular i.v. intravenous JECFA Joint FAO/WHO Expert Committee on Food Additives LDH lactic dehydrogenase LD50 lethal dose, median M molar g microgram mg milligram MIC minimum inhibitory concentration ml milliliter NOEL no-observed-effect level NTP National Toxicology Program (USA) PMNL polymorphonuclear lymphocytes po per os (by mouth) RiBM immortalized lymphoblastoid cell line ...
Not readable? Active Ingredients: Triclopyr 60.45% Herbicide Mode of Action: 4 EPA Signal Word: CAUTION / PRECAUCION Made by Dow AgroSciences, this product keeps right-of-ways, roadsides and other noncrop sites clear of unwanted weeds. ALLIGARE Triclopyr 4 Herbicide 2.5 Gallon Description. Commercial or residential (farm, ranch is residential but no residential surcharge!). Ask A Pro: 866-581-7378 Mon-Fri 9am-5pm ET Live Chat Contact Us. The half-life of triclopyr in water with light is around 1 day. Triclopyr 4 herbicide also kills those tough to control perennial broadleaf weeds. This thread is archived . Sorry, there was a problem saving your cookie preferences. The recommended procedure is basal bark application of Triclopyr. 9 comments. Triclopyr 4 Herbicide (1 Quart) -makes 16 gal of spray mix. Triclopyr 4 Herbicide - 1 QuartTriclopyr 4 is an herbicide used for control of woody plants, annuals, and perennial broadleaf weeds in forests, grass pastures, rangeland, CRP acres, rights-of-way, ...
A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (|i|Mangifera indica|/i|) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.
bandaging, but she needs to wear a diaper (complete with a hole for her cute little tail) and a t-shirt to keep the surgical site clean and dry. Her foster parents have a special ointment that they must apply to her wound twice daily to aid in the healing process. It was obvious to all the staff who attended to Noel that she is feeling like a new Springer and finally getting to enjoy her life without the burden of the sizeable mass she had previously had to tote around wherever she would go. Now, the news that we had hoped we didnt have to share. We have received the pathology report for Noel, and her tests have revealed what her surgeon originally suspected that the mass is a Myxosarcoma, a slow-growing cancer. While we were hoping this was not the case, we have also learned that the cancer is considered a Grade 1, which could provide Noel with the best possible prognosis. There are various treatment options for this type of cancer, ranging from 1) radiation, which can come with complications ...
The Australian Drinking Water Guidelines mandates a safety threshold of 0.02 mg Ni/L water, a value that is based on 70 kg (154 lbs) average body weight, 2 L water consumed daily and 1000 as the safety factor to account for uncertainty of extending animal study results to humans. The residents of New South Wales are assumed to have a similar diet to the rest of Australias population so that the results of the study can be extended to the whole country. The study also assumed that the entire population of New South Wales was nickel-sensitive. This would lead to a lower Lowest Observed Adverse Effect Level (LOAEL) and set stricter limit for tolerable mean nickel concentrations. The result of the study showed that the mean nickel concentration, 0.03 mg/L with a 95% confidence interval of 0.02-0.04 mg/L, is only approximately 7% of the LOAEL. Thus the mean nickel concentration in drinking water in New South Wales appears to have no health risks ...
No biological or any other meaningful alterations in body weight, food consumption, or physical features Ipilimumab were noted. There were no significant dose-related effects in clinical laboratory examinations, and the treatment did not cause gross or microscopic changes in the tissues examined. The occasional presence of neoplasms did not reveal any consistent, dose-related trends in any group. The OECD (2004) derived from this study a NOAEL for chronic oral administration at approximately 2500 mg/kg bw/day. The NOAEL for surface-treated silica in a 6-month. dietary study was at 500 mg/kg bw/day, the only dose tested ( EPA, 2011). The toxic effects of nano- and micron-sized silica particles made from rice husk (and hence biogenic amorphous silica, not SAS) were studied by So et al. (2008). As this study is often discussed in the context of nanosilica in food it is nevertheless included in this review. The silica particles were about 30-90 nm. and 0.5-30 μm in size; their purity given as ...
No biological or any other meaningful alterations in body weight, food consumption, or physical features Ipilimumab were noted. There were no significant dose-related effects in clinical laboratory examinations, and the treatment did not cause gross or microscopic changes in the tissues examined. The occasional presence of neoplasms did not reveal any consistent, dose-related trends in any group. The OECD (2004) derived from this study a NOAEL for chronic oral administration at approximately 2500 mg/kg bw/day. The NOAEL for surface-treated silica in a 6-month. dietary study was at 500 mg/kg bw/day, the only dose tested ( EPA, 2011). The toxic effects of nano- and micron-sized silica particles made from rice husk (and hence biogenic amorphous silica, not SAS) were studied by So et al. (2008). As this study is often discussed in the context of nanosilica in food it is nevertheless included in this review. The silica particles were about 30-90 nm. and 0.5-30 μm in size; their purity given as ...
Read Irish Pantry : Traditional Breads, Preserves, and Goodies to Feed the Ones You Love by Noel McMeel and Lynn Marie Hulsman by Noel McMeel, Lynn Marie Hulsman for free with a 30 day free trial. Read eBook on the web, iPad, iPhone and Android
Check out the catalogue with the current sales in Noel Leeming in Auckland - Unit E, Manukau Supa Centa, Cnr Cavendish & Lambie Drvs, Manukau. ⭐ Weekly mailers for Noel Leeming in Auckland - Unit E, Manukau Supa Centa, Cnr Cavendish & Lambie Drvs, Manukau.
This study was aimed to evaluate the effect on spermatogenesis of a 62kDa protein (Rp) isolated from 50% ethanolic extract of the root of Ricinus communis in mice. A dose response study in mice revealed that 25mg/kg body weight/day was the most effective dose. Swiss strain mature male mice of 30 days old were divided into two group namely control and Rp treated (25mg/kg body weight/day). The study ...
For the registration of each substance under the European chemicals regulation REACH, manufacturers or importers have to quote assessment benchmarks on which the protective measures are based. Among these assessment yardsticks are Derived No-Effect Levels (DNELs). The REACH regulation defines them as exposure levels beneath which a substance does not harm human health.. The GESTIS DNEL list of the German Social Accident Insurance (DGUV) is based on a compilation conducted by the social accident insurance institution for the construction industry which makes available workplace-related DNELs that have been established by manufacturers and importers on their own responsibility and are published in this form by the European Chemicals Agency (ECHA).. The DGUV GESTIS DNEL list currently contains DNELs for workers (local and/or systemic effects during long-term inhalation exposure) for roughly 6,000 substances. If different DNELs are published for a single substance, they are presented side-by-side. ...
Figure 2: Thymus gland: comparison of normal (control) tissue to tissue in a male from the 3000/4000 mg/kg bw/day group showing decreased number of cortical lymphocytes, 14-day study ...
Currently, products made with nanomaterials are used widely, especially in biology, bio-technologies, and medical areas. different NPs), and each of the NPs were characterized by numerous techniques, for example, zeta potentials, scanning electron microscopy, and transmission electron microscopy. Evaluation of the no observed adverse effect level and systemic toxicities of all NPs were performed by thorough evaluation steps and the toxicokinetics step, which included in vivo studies with zinc oxide and silica NPs. A peer review committee was structured to evaluate and verify the reliability of toxicity checks, and the risk communication step was also needed to convey the current findings to academia, industry, and consumers. Several limitations were experienced in the RT-NASA project, and they are discussed for thought for improvements in future studies. Keywords: nanomaterials, nanotoxicity, toxicokinetics, physicochemical house, peer review Intro Nanoparticles (NPs) refer to compounds or ...
If sixty years of uninterrupted support from the National Institutes of Health is not the longest grant on record, it must be an awfully close second. But then, Noel Rose is no ordinary scientist-his pioneering studies on autoimmune thyroiditis in the 1950s helped to initiate the modern era of research on autoimmune disease. His team has continued to make major breakthroughs in revealing the genetic, infectious, and environmental factors that increase risk for autoimmune disease and trigger its onset. In 1999, Rose became the founding director of the Johns Hopkins Autoimmune Disease Research Center, which coordinates and promotes clinical and basic science research on at least 80 known autoimmune diseases that attack every system in the body.. Rose is also no ordinary donor. As chair of the JHSPH Department of Immunology and Infectious Diseases (now the W. Harry Feinstone Department of Molecular Microbiology and Immunology) for 13 years, Rose gained an inside knowledge of how transformative ...
Full house: A photograph from May last year shows the Radfords with their brood - and the then newborn baby Tillie May, who is now almost a year old. Sue finished school and married Noel when she was 18, planning to have perhaps another one or two children.. Once Sophie and Chloe had arrived, however, the couple discovered they were enjoying parenthood so much that they just kept going.. It was after the arrival of Jack, 14, and while Mrs Radford was pregnant with Daniel, 12, that the couple found their current house - a nine-bedroom Victorian former old peoples home that was in need of work.. Somebody did joke, Youve got all those bedrooms, youll have to fill them up, said Mrs Radford.. And sure enough it wasnt long before with each new room they decorated, there were children to share it.. In quick succession they had Luke, 10, Millie, nine, Katie, eight, James, seven, Ellie, six and Aimee, five. Then, after a brief gap, came Josh, three, Max, two months, and Tilly May, now nearly ...
Peking Man, a cave man once thought a great hunter who had first tamed fire, actually was a composite of the gnawed remains of some fifty women, children, and men unfortunate enough to have been the prey of the giant cave hyena. Researching the famous fossil site of Dragon Bone Hill in China, scientists Noel T. Boaz and Russell L.
Gina L. Noel, Massage Therapist. Techniques practiced: Cancer/Oncology Massage, Deep Tissue massage, Hot Stone Therapy, Pregnancy Massage, Sports Massage
We rely on advertising to help fund our award-winning journalism.. We urge you to turn off your ad blocker for The Telegraph website so that you can continue to access our quality content in the future.. Thank you for your support.. ...
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The Philadelphia 76ers officially introduced Nerlens Noel, acquired in the draft-day trade that sent All-Star Jrue Holiday to the New Orleans Pelicans. - Michael Kaskey-Blomain, Philadelphia Philly.com
Health,...Rat study suggests liver danger but doses must be very high ...WEDNESDAY Sept. 26 (HealthDay News) -- Very high doses of caffeine an...This combo produces a byproduct enzyme thats toxic to the organ rese...This toxic twosome can occur not only by drinking caffeine while takin...,Caffeine,Plus,Acetaminophen,Toxic,for,Some,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Rat Liver Metabolism database was created by LMC within the scope of the project Japanese Hazard Evaluation Support System for predicting repeated dose toxicity. Currently it is maintained by LMC.. Chemical Identification. Parent chemicals are defined with CAS, SMILES, IUPAC name and chemical name(s), while metabolites are described with SMILES and chemical name(s). For each parent chemical there is a metabolic map presenting the transformations leading to occurrence of the observed metabolites. In some cases additional intermediates are introduced in order to clarify the transition of metabolites from one to the next observed level. These intermediates are marked with special flags that denote that the metabolites are not observed during the experiment. Along with metabolic transformations each map is accompanied with wide range of supporting information - test species details, experimental conditions, sampling and processing methods, dosing information, etc.. Content. The database contains ...
I was already a competitive athlete when I began the Patton Protocol. My regular 30-mile bike ride- with a 4000 foot climb- took me 2 hours and 20 minutes. Nov 27, 2007 - Founder of T.A. Sciences Noel Thomas Patton read my recent blog post Of course, another reason not to go on the Patton Protocol at this However, the highly purified form of the compound, the administration at doses and for the length of time of 6-12 months in what is called the Patton Protocol, has Jan 6, 2014 - not TA-65 alone which was tested, but rather Patton Protocol-1, composed of TA-65, a [separate] dietary supplement pack, laboratory testingAug 9, 2010 - We conclude that the protocol lengthens critically short telomeres and .. Medical Group which offers TA-65 through the Patton Protocol. The PATTON Protocol is named after the visionary founder of TA Sciences, Noel T. Patton. TA Sciences has the sole worldwide exclusive license to TA-65. ...
This report describes some investigations carried out by staff and students at Edith Cowan University over the four years from 1989-1992 in the Shire of Wanneroo following the 1987 proposal by the State Planning Commission to change the zoning of a large tract of land in Wanneroo from rural and semirural to urban. The research team first carried out a profiling exercise in the area involving over 800 residents and conducted interviews to ascertain resident wishes with regard to the zoning classification. This exercise identified those who stood to gain and those who stood to lose by the proposal and took baseline satisfaction with life data against which to measure the social impact of the change if implemented. A follow-up study was conducted in 1991/2 to see how residents felt now about the various zoning alternatives which had been presented over the three years and to measure the impact of the uncertainty hanging over the area on satisfaction with life. A third study in 1992 took satisfaction
|b|The must-read summary of Noel Tichy and Warren Bennis book: Judgment: How Winning Leaders Make Great Calls.|br||br||/b|This complete summary of the ideas from Noel Tichy and Warren Bennis book Judgment shows how what divides average leaders from great ones is the ability to make excellent decisions in the face of ambiguity, conflicting demands and time pressure. By exercising sound judgment, leaders add value to their organisation. In their book, the authors explain that judgement involves three dimensions: time, domains and resources. This summary takes the reader through each of these stages and suggests how they can be implemented.|br||br||b|Added-value of this summary:|br||/b|? Save time|br|? Understand key concepts|br|? Expand your business knowledge|br||br||b|To learn more, read Judgment and discover the key to becoming a great manager that makes great decisions.|/b||br|