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Nitrazepam (brand names Alodorm and Mogadon, among others) is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia. It also has sedative (calming) properties, as well as amnestic (inducing forgetfulness), anticonvulsant, and skeletal muscle relaxant effects. Nitrazepam is used to treat short-term sleeping problems (insomnia), namely difficulty falling asleep, frequent awakening, early awakening, or a combination of each. Nitrazepam is sometimes tried to treat epilepsy when other medications fail. It has been found to be more effective than clonazepam in the treatment of West syndrome, which is an age-dependent epilepsy, affecting the very young. In uncontrolled studies, nitrazepam has shown effectiveness in infantile spasms and is sometimes considered when other anti-seizure drugs have failed. However, drowsiness, hypotonia, and most significantly tolerance to anti-seizure effects typically develop with long term treatment, generally ...

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Mogadon tablets contain the active ingredient nitrazepam, which is a type of medicine called a benzodiazepine. Nitrazepam is also available without a brand name, ie as the generic medicine.

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NITRAZEPAM WARNINGS. Nitrazepam should be used with caution in: the elderly, women who are pregnant or who are breastfeeding, patients with liver or kidney problems, acute porphyria (an inherited blood disorder, causing skinblisters, belly pain and brain or nervous system disorders), myasthenia gravis, a history of drug of alcohol abuse, depression or anxiety with depression, respiratory diseases, or personality disorders. It should not be used in: those under 18 years of age, patients with respiratory depression (when breathing is slower an/or less deep than normal), those with unstable myasthenia gravis (a muscle weakness disease), acute pulmonary insufficiency (failure of the pulmonary valve in the heart, permitting blood to back-flow into the right ventricle), severe liver problems, sleep apnoea syndrome (when breathing stops temporarily when asleep), a phobia (irrational fear of something), an obsession or chronic psychosis. Also see list of precautions and interactions. STORAGE. Protect ...

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The hypnotic and residual sedative effects of the first and seventh of seven regular night-time doses of nitrazepam 5 mg, temazepam 20 mg, and placebo were studied in 58 elderly inpatients. Plasma temazepam and nitrazepam concentrations rose by about 50% and 113% respectively between the mornings of day 1 and day 7. Patients reported sleeping well more often after the first dose of either hypnotic (p less than 0.05), but there was no difference after the seventh dose. Reaction time was unchanged on the morning after the first dose but was significantly prolonged after the seventh dose of both hypnotics (p less than 0.01). The time taken to eliminate the letter E from a page of prose tended to be prolonged after the first dose of both drugs (temazepam v placebo, p less than 0.05; nitrazepam v placebo, not significant) and was further prolonged on the morning after the seventh dose of nitrazepam (nitrazepam v placebo, p less than 0.05). Thus plasma accumulation of the drug was associated with a ...

Mogadon is used to treat sleeping problems, also called insomnia. Mogadon contains the active ingredient Nitrazepam, a benzodiazepine. It is thought to work by its action on brain chemicals. In general, benzodiazepines such as Mogadon should be taken for short periods only (for example 2 4 weeks).. ...

Nimetazepam is distributed more rapidly in the brain than its desmethyl derivative (nitrazepam). The brain concentration of the active metabolites of the former is about twice that of Nitrazepam at 1-hour after oral administration. At least four kinds of reactions is involved in the biotransformation of nimetazepam and its desmethyl derivative (nitrazepam) (demethylation at N-1,hydroxylation at C-3, reduction of the nitro group at C-7 to the amino group and subsequent acetylation of the amino group. The 1-N-demethylation of nimetazepam is slow compared with the other three reactions. Nimetazepam is rapidly hydroxylated at C-3, while the 3-hydroxylation of its desmethyl derivative (nitrazepam) is very slow. The reduction of the nitro group at C-7 and subsequent acetylation are important routes for the excretion of these drugs ...

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Apo-Nitrazepam: Nitrazepam belongs to the class of medications called benzodiazepines. It is used for short-term treatment of sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening. It is also used to manage myoclonic seizures. It works by slowing down the nerves in the brain (the central nervous system).

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An 11-month-old boy born of non-consanguineous marriage presented with a cough for 15 days and fever and breathlessness for 3 days. He had similar complaints at the age of 7 months and was hospitalized for same for 10 days and diagnosed as bronchiolitis and treated with IV antibiotics and nebulization. He was again hospitalized at 8 months of age for pneumonia and treated with IV antibiotics for 14 days. At that time, he was ventilated and bronchoalveolar lavage grew Klebsiella pneumoniae. He has had repeated episodes of cough and breathlessness and has been treated with antibiotics and steroids. On examination, the child had severe respiratory distress with decreased air entry on the left side. He was given nebulization, hydrocortisone but continued to develop stridor and difficulty in breathing. The child was then put under ventilator and condition improved. CT chest showed a retrotracheal bronchogenic cyst. The child underwent excision of the bronchogenic cyst and was alright after that ...

A 4 years old boy presented with cough and breathlessness for one month. His Chest X-Ray showed multiple nodular lesions in lung and CT chest showed extensive bilateral patchy consolidation with nodular infiltrates and mediastinal adenopathy suggestive of TB. Mantoux test and HIV ELISA were negative. His gastric lavage did not show any acid fast bacilli (AFB). He was started on antituberculous therapy (ATT) consisting of Isoniazid, Rifampicin, Pyrazinamide, Ethambutol. He was a patient with cerebral palsy and epilepsy and was also on nitrazepam, sodium valproate, topiramate for his seizures. His ATT course was completed after 1 year and Chest X-Ray was normal. Three months later he again presented with cough and Chest X-Ray showed fibrocavitatory TB in right lower zone. He was started on category 2 of ATT. His sputum smear for AFB was negative and TB culture after 6 weeks did not grow any organism. After 3 months, his Chest X-Ray showed miliary lesions. Parents were counseled regarding ...

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Chronic dietary administration of 6 different benzodiazepine tranquilizers (chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, and nitrazepam) to breeding pairs of Swiss-Webster mice resulted in alterations of the normal patterns of reproductive behavior and fetal growth. Significant decreases in mating performance were seen among mice given diets containing 0.15% chlordiazepoxide, 0.05% diazepam, 0.05 and 0.15% oxazepam, 0.02 and 0.10% prazepam, 0.10% flurazepam, and 0.025% nitrazepam. Offspring in all drug treatments showed significantly depressed body weights at birth.

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Chlormezanone is only found in individuals that have used or taken this drug. It is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem]Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways ...

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Several classes of medications are used in the treatment of insomnia. They include the benzodiazepines, non-benzodiazepine hypnotics, antidepressants, and over-the-counter medications. There are six benzodiazepines that are specifically marketed as hypnotics in the United States or in Canada: flurazepam, temazepam, triazolam, estazolam, quazepam, and (in Canada only) nitrazepam. Several other benzodiazepines (e.g., lorazepam, clonazepam, oxazepam),… Read More ». ...

Side effects of lormetazepam are similar to those of other hypnotic benzodiazepines and can for the most part be regarded as a class effect.[5] In a sleep study, 1 mg lormetazepam increased total sleep time, reduced wakefulness, but did not alter REM sleep. However, at 2 mg doses, there were significant increases in stage 3 sleep and reductions in REM sleep. Rebound effects have been reported after chronic use including rebound REM.[6] In one clinical trial with patients who had prior experience with older hypnotics temazepam and nitrazepam, most preferred lormetazepam due to less heavy sedation, amnesia, and residual effects.[7] Some side effects, including drowsiness, amnesia, and respiratory depression, are increased when lormetazepam is combined with other drugs with similar effects e.g. alcohol and nonbenzodiazepine drugs. Although lormetazepam has been associated with adversely affecting immediate and delayed recall memory functions,[8] studies have shown that lormetazepams amnesic ...

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