Isolated perfused mesenteric arteries of portal vein ligated and sham-operated rats were contracted by methoxamine (3 nmol-3 mumol) and then treated with nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (100 microM), terlipressin or the selective V2 receptor agonist desmopressin (each 0.5 uM). Terlipressin alone reduced and in combination with NG-nitro-L-arginine methyl ester abolished the difference in reactivity to methoxamine between the portal vein ligated and sham-operated groups ...
A role for the NO-cGMP pathway in mediating chemosensory activation of feeding is suggested by intense NADPH diaphorase staining observed in nerve fibers that project from sensory cells in the lips to the CNS and by the presence in the CNS of a NO-activated guanylyl cyclase. In preparations reduced to isolated lips and CNS, intracellular recordings were made from motoneurons driven by the interneurons of the central pattern generator (CPG) for feeding. Fictive feeding in such preparations can be recorded from these motoneurons following the application of sucrose to the lips. Sucrose activation of fictive feeding is inhibited by the NO scavenger hemoglobin, the NO synthase inhibitor N omega-Nitro-L-Arginine Methyl Ester (L-NAME) and by methylene blue, an inhibitor of guanylyl cyclase. Fictive feeding in isolated lip-CNS preparations can be activated without sucrose by superfusion of NO donor molecules such as SNAP and hydroxylamine and by the nonhydrolyzable analog of cGMP, 8-bromo-cGMP. The ...
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In the present study, chronic administration of bosentan, an antagonist of both ETA and ETB receptors, had no significant effect on the systolic BP level reached after 6 weeks of L-NAME treatment, confirming the observation that acute (60 minutes) administration of the selective ETA receptor antagonist BQ-123 could not lower BP in rats treated for 3 weeks with an l-arginine analogue.21 However, the delay in the BP elevation occurring when bosentan was added to L-NAME would suggest that ET is involved in the early hypertensive response to the l-arginine analogue. This observation is in line with studies showing a blunted hypertensive effect of acute L-NAME administrations by ET receptor antagonists12 13 14 and provides experimental evidence to explain the discrepancy in the efficacy of ET receptor antagonists in acute and chronic L-NAME-induced hypertension.. Chronic administration of L-NAME leads to eutrophic remodeling of the basilar artery, as we previously reported.15 The structural ...
The report generally describes d-leucine methyl ester hydrochloride, examines its uses, production methods, patents. D-Leucine methyl ester hydrochloride
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Product Number , 58089751. CAS Number , 5874-57-7. EC , Molecular Formula , -. Molecular Weight , 155.58. Storage Temp , Harmonized Tariff code , Signal Word , ...
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The present results showed that i.p. administration of IL-1β in freely moving rats induced a biphasic increase in mean arterial blood pressure, and that a rise in the plasma concentration of NOx occurred during the second phase of the pressor response (at 3 h after the injection of IL-1β). Furthermore, systemic pretreatment with DEX enhanced the second phase of the pressor response, thus confirming our previous finding (Watanabe et al., 1996), and inhibited the evoked increase in the plasma level of NOx. These results suggest that NO is involved as a vasodilator in the regulation of the late phase of the pressor response, and that the enhancement by DEX of the IL-1-induced rise in blood pressure was, at least in part, due to its inhibition of NO release. This idea is further supported by the finding that one of the most frequently used nonselective NOS inhibitors,l-NAME, both enhanced the IL-1β-induced pressor response and attenuated the NOx response seen in this study. This result indicates ...
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7-N-(4-O-sialosylphenyl)-9-methoxymitosane methyl ester: has antibacterial & antineoplastic activities; structure given in first source
135820-81-4 - WZEHNUMRTRKLTC-OCCSQVGLSA-N - N-Benzyloxycarbonyl-prolyl-alanine methyl ester - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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Applications of Algebra in Dance Composition. This workshop will explore how dance composition can get analytical, precise, and even mathematical- but by no means boring! Regular polyhedra are often used in dance as a means of orienting yourself in space, and in this workshop we will see how algebraic concepts on the vertices of these figures can be related to choreographic devices in dance composition. We will also uncover a way of crafting variations on your own phrase of choreographic work with math!. Bridges Movie Festival. A selection of videos conveying mathematical ideas and ways of thinking. If you like Vi Harts math videos, youll enjoy this collection by a variety of video artists.. Divergence of Sinusoidal Vector Fields: Sources of Flow as Sources of Symmetry. Using the divergence of a vector field we create black and white symmetric patterns resembling patterns commonly found on textiles and baskets. We focus on sinusoidal vector fields of the form because of the interesting ...
TY - JOUR. T1 - Increased organ blood flow in chronic endotoxemia is reversed by nitric oxide synthase inhibition. AU - Meyer, J.. AU - Hinder, F.. AU - Stothert, J.. AU - Traber, L. D.. AU - Herndon, David. AU - Flynn, J. T.. AU - Traber, D. L.. PY - 1994. Y1 - 1994. N2 - We evaluated regional blood flows in a hyperdynamic sepsis model and the reversal of increased flows by blockade of nitric oxide (NO) synthase. Seven awake sheep were continuously infused with Escherichia coli endotoxin [lipopolysaccharide (LPS), 10 ng · kg-1 · min-1] for 48 h. The NO synthase inhibitor N(ω)-nitro-L-arginine methyl ester (L-NAME, 25 mg/kg) was injected after 24 h. Blood flows to systemic organs were determined with the radioactive microsphere technique. LPS induced elevation of cardiac index by 36% (P , 0.05) and a fall in systemic vascular resistance index by 37% (P , 0.05) at 0 h [time of L-NAME administration, 24 h after infusion of LPS had begun]. L-NAME administration normalized cardiac index [6.1 ± ...
Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats.Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney.Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. on the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to ...
This study investigated whether the nitric oxide synthase inhibitor NG-nitro-L-arginine-methyl ester (L-NAME) would alter blood flow and oxygen balance in the ischemic cerebrocortex of isoflurane-anesthetized Long-Evans rats.. Fifteen minutes after middle cerebral artery occlusion, L-NAME (1.5 mg/min per kilogram) was infused intravenously to the L-NAME group (n = 14), and normal saline was given to the control group (n = 14) for 45 minutes. In each group, regional cerebral blood flow was determined with [14C]iodoantipyrine, and arterial and venous oxygen saturations were determined by microspectrophotometry.. In both groups regional cerebral blood flow of the ischemic cortex was significantly lower than that of the contralateral cortex ([mean +/- SD] 55 +/- 13 versus 110 +/- 29 mL/min per 100 g in the control group and 35 +/- 13 versus 90 +/- 24 mL/min per 100 g in the L-NAME group). Compared with the blood flow in the ischemic cortex of the control group, L-NAME significantly reduced ischemic ...
AIM: To elucidate the mechanism of patchouli alcohol (PA) in treatment of rat models of diarrhea-predominant irritable bowel syndrome (IBS-D). METHODS: We studied the effects of PA on colonic spontaneous motility using its cumulative log concentration (3 × 10-7 mol/L to 1 × 10-4 mol/L). We then determined the responses of the proximal and distal colon segments of rats to the following stimuli: (1) carbachol (1 × 10-9 mol/L to 1 × 10-5 mol/L); (2) neurotransmitter antagonists including Nω -nitro-L-arginine methyl ester hydrochloride (10 μmol/L) and (1R*, 2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3 ...
Thermodynamic proton dissociation constants (K_a^T) of the hydrochlorides of some α-amino acid methyl, ethyl and benzyl esters have been determined by potentiometric titration at 25, 37.1 and 50.2°C, and at I = 0.1 mol 1⁻¹. From this temperature dependence, the energetics of the reactions (ΔG˚ , ΔH˚ , ΔS0˚values) were determined and examined. The ester hydrochlorides of the 2-amino acids have pK_a^T values that are about 2 units lower than the corresponding n-alkylammoniums. The major contributors to this large ΔG˚ lowering (acid strengthening) are the strong -I effect of the adjacent alkoxy/benzyloxy carbonyl group which produces a large decrease in ΔH˚ and a reduction in the nett solvent (H₂0) bonding for the free base form of the ester (E) which increases ΔS˚ • pK_a^T values rise sharply from 2-aminoethanoic acid methyl ester hydrochloride (2-AE Me·HCI) to 3-aminopropanoic acid methyl ester hydrochloride (3-AP Me·HCl). There are much smaller rises with further increases ...
Nitric oxide (NO) fluxes released from the surface of individual activated macrophages or cells localized in small aggregates were measured with a novel polarographic self-referencing microsensor. NO fluxes could be detected at distances from the cells of 100-500 microm. The initial flux and the distance from the cells at which NO could be detected were directly related to the number of cells in the immediate vicinity of the probe releasing NO. Thus, whereas NO fluxes of approximately 1 pmol. cm(-2). s(-1) were measured from individual macrophages, aggregates composed of groups of cells varying in number from 18 to 48 cells produced NO fluxes of between approximately 4 and 10 pmol. cm(-2). s(-1). NO fluxes required the presence of L-arginine. Signals were significantly reduced by the addition of hemoglobin and by N-nitro-L-arginine methyl ester. NO fluxes were greatest when the sensor was placed immediately adjacent to cell membranes and declined as the distance from the cell increased. The NO ...
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Spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were distributed into 2 groups: sedentary (SHRsd and WKYsd, n=10 each) and swimming-trained (SHRtr, n=10 and WKYtr, n=10, respectively). The trained group participated in training sessions 5 days/week for 1 h/day with an additional work load of 4% of the animals body weight. After a 10-week sedentary or aerobic training period, the rats were euthanized. The thoracic aortas were removed to evaluate the vasodilator response to acetylcholine (10-10 to 10-4 M) with or without preincubation with L-NG-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10-4 M ...
Hypertension is the second leading primary cause of end-stage renal disease;however, considerable variation exists with respect to the relative risk of hyperten...
International Classification: C07D 233/88 (20060101); C07D 257/00 (20060101); C07D 239/42 (20060101); C07D 233/00 (20060101); C07D 249/14 (20060101); C07D 239/00 (20060101); C07D 257/06 (20060101); C07D 249/00 (20060101); C07D 277/18 (20060101); C07D 231/40 (20060101); C07D 277/00 (20060101); C07D 231/00 (20060101); A61K 031/41 (); A61K 031/415 (); C07D 257/06 (); C07D 231/40 ...
Lack of association between blood pressure, target organ damage and retinopathy in the L-NAME rat hypertension model: Are new animal models of hypertension required? , Ausencia de correlación entre las cifras tensionales, el daño de órgano blanco y la presencia de retinopatía en el modelo animal de hipertentión con L-NAME: ¿Son necesarios nuevos modelos animales en hipertensión arterial ...
formyl-methylhomoseryl-leucyl-phenylalanine methyl ester: an oxygen analog of FMLP-OMe; amino acid sequence given in first source
This page contains information on the chemical Cyclopropanecarboxylic Acid, 3-(2,2-Dichloroethenyl)-2,2-Dimethyl-, Methyl Ester (9ci) including: 2 synonyms/identifiers.
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for CYCLOPROPANECARBOXYLIC ACID 2-PROPYL-,METHYL ESTER,TRANS- (CAS No. 168141-72-8)