Title:Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimers Disease. VOLUME: 12 ISSUE: 6. Author(s):Qianhua Zhao, Qihao Guo, Xiaoniu Liang, Meirong Chen, Yan Zhou, Ding Ding and Zhen Hong. Affiliation:No. 12 Wulumuqi Rd(M), Shanghai, China, 200040.. Keywords:Alzheimers disease, auditory verbal learning test, mild cognitive impairment, operational criteria, Rey-Osterrieth complex figure test, subjective cognitive decline.. Abstract:Objective: To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally balance the sensitivity and specificity. Methods: We focused on 206 non-demented subjects from memory clinic. We then classified each individual as having MCI or ...
TRVB test de retenciГіn visual de Benton manual (Book. 10/9/2018 · The Benton Visual Retention Test - Fifth Edition (BVRT-5) is a clinical and research instrument designed to assess visual memory, visual perception, and visual-constructive abilities and as a supplement to mental examinations of persons suspected of abnormality. Three forms, C, D, and E …, However, during the clinical psychology area of the 1940s and 1950s, the qualitative approach to assessment gave way to the use of individual psychometric tests, many of which could be scored such as the Benton Visual Retention Test (Benton, 1974), the Graham-Kendall Memory for Designs (1960), and the Bender Gestalt (Bender, 1938).. More than 50 years of proven clinical utility is the hallmark of Benton Visual Retention Test®.This test has proven its sensitivity to reading disabilities, nonverbal learning disabilities, traumatic brain injury, Attention-Deficit Disorder, Alzheimers, and other forms of dementia. 11/22/2006 · The Benton ...
TY - JOUR. T1 - Effects of low visual acuity on neuropsychological test scores. T2 - A simulation study. AU - de Haan, Gera A.. AU - Tucha, Oliver. AU - Heutink, Joost. PY - 2020. Y1 - 2020. N2 - Objective: To systematically examine the effect of low visual acuity (LVA) on a number of commonly used neuropsychological tests.Method: In this study, the influence of LVA on a number of commonly used neuropsychological tests was examined in 238 healthy older adults (aged 50-80) without visual or neurological impairment. LVA was simulated using simulation glasses.Results: It was found that a simulated LVA of ∼0.2 (decimal acuity; Snellen 6/30 or 20/100, LogMAR 0.7) had a negative impact on test performance for the Trail Making Test, Complex Figure of Rey (copy score), and Visual Object and Space Perception battery subtest 3, but not for the Mini Mental State Examination and Balloons test. For some tests, the negative impact of LVA increased with age.Conclusions: These results have important ...
The effect of seasons and seasonal variation on neuropsychological test performance in patients with bipolar I disorder and their first-degree ...
TY - JOUR. T1 - Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). T2 - Normative Data for Older Adults. AU - Olaithe, Michelle. AU - Weinborn, Michael. AU - Lowndes, Talitha. AU - Ng, Amanda. AU - Hodgson, Erica. AU - Fine, Lara Aishling. AU - Parker, Denise. AU - Pushpanathan, Maria. AU - Bayliss, Donna. AU - Anderson, Michael. AU - Bucks, Romola. PY - 2019/12. Y1 - 2019/12. N2 - ObjectiveProvide updated older adult (ages 60+) normative data for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Form A, using regression techniques, and corrected for education, age, and gender.MethodParticipants (aged 60-93 years; N = 415) were recruited through the Healthy Ageing Research Program (HARP), University of Western Australia, and completed Form A of the RBANS as part of a wider neuropsychological test battery. Regression-based techniques were used to generate normative data rather than means-based methods. This methodology allows for the control ...
The effects of psychological factors on neuropsychological test performance https://www.upress.umn.edu/test-division/bibliography/1990-1999/1997/johnston_effects_1997 https://www.upress.umn.edu/logo.png ...
TY - JOUR. T1 - Regional brain atrophy in HIV‐1 infection. T2 - association with specific neuropsychological test performance. AU - Hestad, K.. AU - McArthur, J. H.. AU - Pan, G. J.Dal. AU - Selnes, O. A.. AU - Nance‐Sproson, T. E.. AU - Aylward, E.. AU - Mathews, V. P.. AU - McArthur, J. C.. PY - 1993/8. Y1 - 1993/8. N2 - Quantified magnetic resonance imaging (MRI) was related to neuropsychological (NP) test scores in an asymptomatic HIV‐1 seropositive group, a non‐demented AIDS/ARC group, a group of subjects with HIV‐1 dementia, and a seronegative control group. The MRIs were quantified using three planimetric measures of brain structure: the bicaudate ratio (a measure of caudate region atrophy), the bifrontal ratio (a measure of frontal region atrophy), and the ventricle to brain ratio (a measure of overall cerebral atrophy). Cognitive performance was assessed with standard NP tests. Significant correlations between the MRI ratios and many of the NP tests were observed. Of the tests ...
To characterize the relationship between dispersion-based intra-individual variability (IIVd) in neuropsychological test performance and brain volume among HIV seropositive and seronegative men and to
TY - JOUR. T1 - Are we exaggerating neuropsychological impairment in depression? Reopening a closed chapter. AU - Moritz, Steffen. AU - Stöckert, Katrin. AU - Hauschildt, Marit. AU - Lill, Hannah. AU - Jelinek, Lena. AU - Beblo, Thomas. AU - Diedrich, Sabrina. AU - Arlt, Sönke. PY - 2017. Y1 - 2017. N2 - Background: Meta-analyses conclude that individuals with depression display neurocognitive deficits. However, the extent to which some of these impairments occur due to secondary influences, and thus in part represent epiphenomena, has rarely been tested. Therefore, the authors examined the impact of performance motivation, attitude towards cognitive assessment, and momentary symptoms during assessment on neuropsychological test results in depression. Research design and methods: Forty-five patients with depression and 60 nonclinical individuals underwent a comprehensive neuropsychological test battery. Before and after the assessment, each participant was asked to complete the Momentary ...
The Rey-Osterrieth (ROCF) and Taylor (TCF) complex figure tests are widely used to assess visuospatial and constructional abilities as well as visual/non-verbal memory. Normative data adjusted to the cultural and linguistic reality of older Quebec-French individuals is still nonexistent for these te …
TY - JOUR. T1 - Complex real-world functioning and neuropsychological test performance in older adults. AU - Baird, A.. AU - Podell, Kenneth. AU - Lovell, M.. AU - McGinty, S. B.. PY - 2001/12/1. Y1 - 2001/12/1. N2 - In stepwise regression analyses with Independent Living Scales (ILS) summary and subscale scores as the dependent variables, 8 of 10 psychometric measures from our battery for older adults emerged as important predictors for 69 patients referred for clinical assessment. The Dementia Rating Scale (DRS) score entered first for 6/8 analyses. However, measures of confrontation naming, oral reading, verbal fluency, paragraph recall, visual perception, complex attention, and depression also added explanatory power. Multiple Rs ranged from .66 to .88 except for the Social Adjustment subscale, which correlated only with the depression scale.. AB - In stepwise regression analyses with Independent Living Scales (ILS) summary and subscale scores as the dependent variables, 8 of 10 psychometric ...
Introduction: Semi-automatic neuropsychological testing has gained a position both in clinical use and in research. Comparison studies with traditional neuropsychological tests are sparse and the role of such semi-automated testing is debated. To integrate semi-automated neuropsychological testing in the established clinical setting the tests must be validated in the patient groups addressed. The aim of this study was to validate Cambridge Neuropsychological Tests Automated Battery (CANTAB) in patients with epilepsy. Material and Methods: Patients scheduled for traditional neuropsychological testing with Category test (CT), Trail Making Test part B (TMT-B), WAIS-III and WMS-R were also asked to complete the CANTAB battery. Our hypothesis was that memory tests from CANTAB (DMS, PAL) would correlate with visual memory tests from WMS-R and that a test of executive functions from CANTAB (SOC) would correlate with functions tested with TMT-B, CT and WAIS-III. Results: Scores from DMS correlated strongly with
Neuropsychological examination is an important way of formally assessing brain function. While there is so much documentation about the influence that some factors such as age and education has on neuropsychological tests (NP), not so much has been done to assess the influence that residency (rural/urban) may have. The specific objectives of this study were to establish if there is a significant difference in mean test scores on NP tests between rural and urban participants, to assess which tests on the Zambia Neurobehavioural Test Battery (ZNTB) are more affected by the participants residency (rural/urban) and to determine the extent to which education, gender and age predict test performance on NP tests for rural and urban participants. The participants (324) were drawn from both urban and rural areas of Zambia (Rural =152 and Urban = 172). However, only 234 participants (Rural =152 and Urban 82) were used for all the analyses in this particular study. The 234 participants were used as the ...
The conventional scores of the neuropsychological batteries are not fully optimized for diagnosing dementia despite their variety and abundance of information. To achieve low-cost high-accuracy diagnose performance for dementia using a neuropsychological battery, a novel framework is proposed using the response profiles of 2666 cognitively normal elderly individuals and 435 dementia patients who have participated in the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD). The key idea of the proposed framework is to propose a cost-effective and precise two-stage classification procedure that employed Mini Mental Status Examination (MMSE) as a screening test and the KLOSCAD Neuropsychological Assessment Battery as a diagnostic test using deep learning. In addition, an evaluation procedure of redundant variables is introduced to prevent performance degradation. A missing data imputation method is also presented to increase the robustness by recovering information loss. The proposed deep
Objectives Endophenotypes in schizophrenia research is a contemporary approach to studying this heterogeneous mental illness, and several candidate neurophysiological markers (e.g. P50 sensory gating) and neuropsychological tests (e.g. Continuous Performance Test (CPT) and Wisconsin Card Sorting Test (WCST)) have been proposed. However, the clinical utility of a single marker appears to be limited. In the present study, we aimed to construct a diagnostic model incorporating P50 sensory gating with other neuropsychological tests in order to improve the clinical utility. Methods We recruited clinically stable outpatients meeting DSM-IV criteria of schizophrenia and age- and gender-matched healthy controls. Participants underwent P50 sensory gating experimental sessions and batteries of neuropsychological tests, including CPT, WCST and Wechsler Adult Intelligence Scale Third Edition (WAIS-III). Results A total of 106 schizophrenia patients and 74 healthy controls were enrolled. Compared with healthy
TY - JOUR. T1 - Predicting Alzheimers disease. T2 - Neuropsychological tests, self-reports, and informant reports of cognitive difficulties. AU - Rabin, Laura A.. AU - Wang, Cuiling. AU - Katz, Mindy J.. AU - Derby, Carol A.. AU - Buschke, Herman. AU - Lipton, Richard B.. PY - 2012/6. Y1 - 2012/6. N2 - OBJECTIVES: To investigate the independent and combined contributions to the risk of Alzheimers disease (AD) of three important domains of cognitive assessment: neuropsychological measurement, self-reports, and informant reports. DESIGN: Longitudinal, community-based sample. SETTING: Einstein Aging Study. PARTICIPANTS: Six hundred twenty-seven individuals without dementia aged 70 and older systematically recruited from the Bronx, New York. MEASUREMENTS: Comprehensive assessment included neurological examination, behavioral questions, and neuropsychological testing. AD diagnoses were based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria assigned at a ...
This analysis of individual patient data across the 31 studies provides further evidence that euthymic bipolar patients exhibit moderate cognitive impairments on a range of standard neuropsychological tests. Cognitive deficits remain significant even after controlling for key baseline factors such as age, IQ and gender that are known to affect neuropsychological test performance. The current level of minor depressive symptoms and the effects of some drug treatments may contribute to these effects but cannot explain them. Thus, there is significant residual cognitive impairment associated with bipolar disorder over and above the known confounding factors.. The effect sizes for such deficits were lower (0.26-0.63) than those reported in prior meta-analyses [6-8, 10] (ds = 0.5-1.0). This reduction in observed effect sizes is in part due to controlling better for the effect of age, IQ and gender. However, we were also able to include unpublished studies which often had the lowest effect sizes [e.g. ...
It has long been appreciated among clinical neuropsychologists that both primary and secondary factors contribute to cognitive dysfunction in neurological patients. Primary influences are the direct result of the extent and location of damage to the brain. Secondary influences stem from something associated with brain injury or disease besides the specific areas of the brain affected.
It has long been appreciated among clinical neuropsychologists that both primary and secondary factors contribute to cognitive dysfunction in neurological patients. Primary influences are the direct result of the extent and location of damage to the brain. Secondary influences stem from something associated with brain injury or disease besides the specific areas of the brain affected.
OBJECTIVE: To identify type 1 diabetes-related predictors of change in the neuropsychological profiles of children over the first 2 years of the illness. RESEARCH DESIGN AND METHODS: Children (n = 116) aged 3-14 years were assessed soon after diagnosis and re-evaluated 2 years later to examine relationships between illness variables, such as age of onset and metabolic control history, and changes in neuropsychological status over the first 2 years of type 1 diabetes. RESULTS: Illness variables were significant predictors of change in neuropsychological test scores within 2 years of onset of type 1 diabetes. Age of onset of type 1 diabetes predicted negative change on Performance Intelligence Quotient, whereas both recurrent severe hypoglycemia and chronic hyperglycemia were associated with reduced memory and learning capacity. CONCLUSIONS: These results suggest that the relationship between metabolic control and neuropsychological risk is nonlinear in that children with either recurrent severe ...
Introduction: With the recent publication of new criteria for the diagnosis of preclinical Alzheimers disease (AD), there is a need for neuropsychological tools that take premorbid functioning into account in order to detect subtle cognitive decline. Using demographic adjustments is one method for increasing the sensitivity of commonly used measures. We sought to provide a useful online z-score calculator that yields estimates of percentile ranges and adjusts individual performance based on sex, age and/or education for each of the neuropsychological tests of the National Alzheimers Coordinating Center Uniform Data Set (NACC, UDS). In addition, we aimed to provide an easily accessible method of creating norms for other clinical researchers for their own, unique data sets. Methods: Data from 3,268 clinically cognitively-normal older UDS subjects from a cohort reported by Weintraub and colleagues (2009) were included. For all neuropsychological tests, z-scores were estimated by subtracting the ...
Many studies have reported on the pattern of neuropsychological test performance across varied seizure diagnosis populations. Far fewer studies have evaluated the accuracy of the clinical neuropsychologist in formulating an impression of the seizure diagnosis based on results of neuropsychological assessment, or compared the accuracy of clinical neuropsychological judgment to results of statistical prediction. Accuracy of clinical neuropsychological versus statistical prediction was investigated in four seizure classification scenarios. While both methods outperformed chance, accuracy of clinical neuropsychological classification was either equivalent or superior to statistical prediction. Results support the utility and validity of clinical neuropsychological judgment in epilepsy treatment settings
Objective: Computerized neurocognitive assessment tools (NCATS) are often used as a screening tool to identify cognitive deficits after mild traumatic brain injury (mTBI). However, differing methodology across studies renders it difficult to identify a consensus regarding the validity of NCATs. Thus, studies where multiple NCATs are administered in the same sample using the same methodology are warranted. Method: We investigated the validity of four NCATs: the ANAM4, CNS-VS, CogState, and ImPACT. Two NCATs were randomly assigned and a battery of traditional neuropsychological (NP) tests administered to healthy control active duty service members (n = 272) and to service members within 7 days of an mTBI (n = 231). Analyses included correlations between NCAT and the NP test scores to investigate convergent and discriminant validity, and regression analyses to identify the unique variance in NCAT and NP scores attributed to group status. Effect sizes (Cohens f2) were calculated to guide ...
Neuropsychological impairment is widely accepted as being common in acquired immunodeficiency syndrome (AIDS) but infrequent in asymptomatic human immunodeficiency virus (HIV)-infected individuals. The neuropsychological function of a homogenous sample of HIV-infected haemophiliacs was investigated. Neuropsychological impairment, the nature of which is compatible with that described in the existing literature, was found in one of four AIDS cases. Eleven AIDS related complex (ARC) and 12 asymptomatic HIV-infected individuals were free of neuropsychological deficit.. ...
TY - JOUR. T1 - How specific is specific impairment?. AU - Bird, Héctor R.. AU - Davies, Mark. AU - Fisher, Prudence. AU - Narrow, William. AU - Jensen, Peter S.. AU - Hoven, Christina. AU - Cohen, Patricia. AU - Dulcan, Mina K.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Objective: To describe the usefulness of impairment items placed at the end of each diagnostic section of a structured instrument (the Diagnostic Interview Schedule for Children Version 2.3) in an attempt to link impairment to specific diagnoses. Method: Data from 3 sites of the Methods for the Epidemiology of Child and Adolescent Mental Disorders Study were used to assess the reliability of the specific impairment measures by diagnosis, the extent to which global and specific measures of impairment impact on prevalence rates, the concordance between global and specific impairment, and the degree to which there may be a halo effect among specific impairment ratings. Results: Test-retest reliability was better for parent than youth ...
This study as you can see in the Summary/conclusion & Results slides just below did not find an association between EFV plasma levels & neurocognitive function but most patients had EFV concentrations in the normal range. But they found better neuro function - total NPZ scores, learning & language function with higher metabolite levels. As it was discussed in the Q&A - there were not very high EFV plasma levels in these pts that is why they did not see a correlation between levels & psych performance; comment by Charles Flexner - none of pts have HCV & having higher metabolite levels might be a surrogate for healthier liver & people with healthier livers tend to perform better on psychiatric performance tests. Based on comments by author in Q&A patients did not have drug abuse either ...
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Introduction/objective. It is widely accepted that researchers must have normative data that has been duly validated and culturally adapted in order to ensure that assessments of cognitive performance contain the lowest amount of contamination from other factors.1 This objective was clearly outlined for the Neuronorma Project, an extensive Spanish study that was published recently.2. Neuropsychological evaluation (NPE) for dementia may be more or less extensive and detailed depending on the complexity of the evaluation tools in use: brief scales, functional scales, simple test batteries, complex test batteries, and ideographic studies.3 The most recommendable method for performing NPE for dementia is to use a multidimensional test battery with psychometric properties including sensitive tests for each cognitive area.4 NPE is a key procedure in diagnosing, classifying, and monitoring the course of mild cognitive impairment, Alzheimers disease, and other types of dementia.5,6 The RBANS battery7 ...
TY - JOUR. T1 - The cognitive change index as a measure of self and informant perception of cognitive decline. T2 - Relation to neuropsychological tests. AU - Rattanabannakit, Chatchawan. AU - Risacher, Shannon L.. AU - Gao, Sujuan. AU - Lane, Kathleen A.. AU - Brown, Steven A.. AU - McDonald, Brenna C.. AU - Unverzagt, Frederick W.. AU - Apostolova, Liana G.. AU - Saykin, Andrew J.. AU - Farlow, Martin R.. PY - 2016/4/12. Y1 - 2016/4/12. N2 - Background: The perception of cognitive decline by individuals and those who know them well ( informants ) has been inconsistently associated with objective cognitive performance, but strongly associated with depressive symptoms.∗Objective:We investigated associations of self-report, informant-report, and discrepancy between self- and informant-report of cognitive decline obtained from the Cognitive Change Index (CCI) with cognitive test performance and self-reported depressive symptoms.∗Methods: 267 participants with normal cognition, mild cognitive ...
Abstract:While research supports the use of neuropsychological measures to predict real-world function (i.e., vocational functioning and activities of daily living) among younger and middle-aged HIV+ adults, no studies have evaluated the validity of using neuropsychological measures for this purpose among older HIV+ adults. The objective of this study was to determine whether neuropsychological measures would demonstrate comparable utility in predicting vocational functioning among younger and older HIV+ adults. Methods: All participants (N=111), including 73 younger adults (all , 35 years; M=31.32, SD=3.19) and 38 older adults (all , 50 years; M=53.79, SD=3.23), underwent comprehensive neuromedical, neuropsychological, and vocational evaluations. The neuropsychological (NP) evaluation assessed verbal skills, attention/working memory, processing speed, learning, memory, motor and abstraction/executive functioning. Vocational functioning was evaluated with the Valpar Vocational Assessment ...
Dysexecutive syndrome (DES) consists of a group of symptoms, usually resulting from brain damage, that fall into cognitive, behavioural and emotional categories and tend to occur together. The term was introduced by Alan Baddeley to describe a common pattern of dysfunction in executive functions, such as planning, abstract thinking, flexibility and behavioural control. It is thought to be Baddeleys hypothesized working memory system and the central executive that are the hypothetical systems impaired in DES. The syndrome was once known as frontal lobe syndrome, however dysexecutive syndrome is preferred because it emphasizes the functional pattern of deficits (the symptoms) over the location of the syndrome in the frontal lobe, which is often not the only area affected. Classification code in ICD-10 - F07 Symptoms of DES fall into three broad categories: cognitive, emotional and behavioural. Many of the symptoms can be seen as a direct result of impairment to the central executive component of ...
What is the purpose of neuropsychological testing? Neuropsychological tests can be helpful to determine the reasons for changes in the following areas: cognitive functioning, behavior, day-to-day tasks at work/school and/or home, and self-care (e.g., money management, ability to make personal decisions). A variety of conditions typically warrant neuropsychological testing. Here are some examples: cognitive problems of unclear cause; dementia (e.g., Alzheimers); ADHD; learning disorders; traumatic brain injury and concussions; Movement disorders (e.g., Parkinsons); multiple sclerosis; stroke and cerebrovascular disease; brain tumor; infectious diseases (e.g., Lyme disease); metabolic illness or toxin exposure; learning disorders; psychiatric disorders; and alcohol and substance use disorders. What is a neuropsychological test? Neuropsychological testing is a scientifically-based way to use paper-and-pencil and computerized tasks to assess an individuals functioning in the following domains:
TY - JOUR. T1 - Diagnostic accuracy of percent retention scores on RBANS verbal memory subtests for the diagnosis of Alzheimers disease and mild cognitive impairment. AU - Clark, Joy Humphreys. AU - Hobson, Valerie L.. AU - OBryant, Sid E.. PY - 2010/6. Y1 - 2010/6. N2 - Previous research has supported the use of percent retention scores in the neuropsychological assessment of memory, and many widely used memory measures provide for the calculation and normative comparison of these scores. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), an increasingly utilized assessment tool for cognitive impairment, provides normative data on delayed memory total raw scores only. The current study was aimed at determining the diagnostic accuracy of a novel percent retention score calculated from RBANS verbal memory subtests (delayed recall minus last learning trial) when distinguishing between normal controls, individuals diagnosed with Mild Cognitive Impairment, and ...
Background: The study of neuropsychological mechanisms is crucial for the advancement of prevention and treatment of mental disorders. However, the field of global mental health (GMH) lacks neuropsychological tools with cross-cultural applicability that can be administered in low resource settings. Technological innovations have potential to address this gap.. Objective: Our goal is twofold: (a) Adapt culturally appropriate neuropsychological tools to be delivered in tablet-based formats for South Asian adolescents at risk of suicide; (b) Develop and document an innovative technologies systematic adaptation procedure that can be applied to other GMH settings.. Aims: (1) Develop culturally appropriate stimuli for neuropsychological assessment using qualitative research with adolescents in India and Nepal. (2) Develop tablet-based versions of neuropsychological tests. (3) Pilot tablet-based administration with 50 adolescents.. Significance: The availability of valid and easy to use ...
Required for administration: A stopwatch History and Use First proposed by Swiss psychologist André Rey in 1941 and further standardized by Paul-Alexandre Osterrieth in 1944, it is frequently used to further elucidate any secondary effect of brain injury in neurological patients, to test for the presence of dementia, or to study the degree of cognitive development in children.Osterreith standardized the administration procedure, obtained normative data from 230 normal children and 60 adults, and provided interpretative guidance* visuospatial abilities, memory, attention, planning, and working memory (executive functions) Compared to Other Similar Tests The RCFT relates to other memory and visual constructional tests, such as the Token Test, BVRT total correct and RAVLT Trial 5. It assesses similar abilities and functions as the Hooper Visual Organisation Test (HVOT), Line Orientation, and Ravens Standard Progressive Matrices. However, unlike the RCFT, the latter test does not require motor ...
Neuropsychological tests are standardized tasks used to measure psychological functioning that is associated with a particular brain structure. These tests often are used in diagnosing a cognitive deficiency resulting from brain injuries. Currently, there are a limited number of studies that have focused on standardization of neuropsychological tests in Latin America. Therefore, the vast majority of cognitive tests used in the evaluation of patients with brain damage have no normative parameters adjusted to the cultural characteristics of Latinos and Latinas. As a result, neuropsychological diagnoses among this population may be inadequate, and evaluation of rehabilitation program effectiveness limited. The importance of culturally appropriate indices of neurological tests cannot be overstated; of all the problems presented by individuals with brain injuries, cognitive disorders are the leading source of disability for adequate work, family, and social reintegration among this group. There is an urgent
In this study we evaluated the correlation between neuropsychological impairment (measured with the Brief Repeatable Battery Neuropsychological Tests) and (juxta)cortical lesions detected with FLAIR and the relative sensitivity of the FLAIR sequence compared to spin-echo MRI sequences in detecting ( …
Results Mean overall score difference between DCL 1-3 and DCL 4 was significant for all tests, ranging from 14.87 points (p , 0.0001) in the Stroop word reading test to 8.3 points (p , 0.0001) in the verbal fluency test. In the DCL 1-3 group, annual change was significant for Stroop word reading (-0.99 points, p = 0.014) and for the Symbol Digit Modalities Test (-0.55 points, p = 0.008). In the DCL 4 group, annual change was significant for all UHDRS cognitive tests, changes ranging from - 0.56 (p = 0.0001) points in the verbal fluency test to -3.36 points (p , 0.0001) in the Stroop word reading test.. ...
Contemporary Approaches to Neuropsychological Assessment (see record 1997-08958-000) is an edited book with the primary objective to clearly reflect stable and changing trends in the field(p. 393). This goal is successfully accomplished in an organized, concise manner. The first half of the book includes a substantive chapter on basic psychometric concepts and issues in neuropsychological assessment. The second half of the book summarizes recent trends pertinent to neuropsychological assessment. (PsycINFO Database Record (c) 2017 APA, all rights reserved) ...
Throughout my career, I have examined the utility of existing neuropsychological tests to detect, quantify, and differentially diagnose neurodegenerative diseases and other neurological conditions. However, when there were inadequate existing measures to answer clinical and research needs, I developed and published a new instrument. For example, in my early studies of post-stroke depression, there was a need for an instrument to measure various mood states in patients with aphasia and cognitive impairment. I, therefore, developed the Visual Analog Mood Scales (VAMS). In addition, based upon my training in the Process Approach to neuropsychological assessment under Dr. Edith Kaplan, I developed the Boston Qualitative Scoring System (BQSS) for the Rey-Osterreith Complex Figure (ROCF) with colleagues and trainees, thus creating a more comprehensive and sensitive method of evaluating and quantifying the rich information previously missed in previous methods of scoring the commonly used ROCF. And, ...
Methods A cross sectional study was performed on 208 workers from a paint factory who were exposed to lower mean concentrations, as per Mexican official norms, to OS mixtures, mainly of toluene and xylene. Using the cumulative index for toluene (concentration weighted in time x years working at the company), two groups were formed: one for low and one for higher high exposure. Thirteen neuropsychological tests evaluated cognitive, motor, and four evaluated affective aspects.. ...
What Is Neuropsychological Testing? Isnt neuropsychological testing a soft-science that only generates vague results?. No. During the past decade neuropsychological testing has become a very sophisticated science. Tests that are currently available are highly accurate, standardized instruments, with predictive accuracy in the 80-95% range. They are validated through clinical trials, adhering to stringent, objective measures. Neuropsychological tests provide quantifiable results that indicate the amount of deviation from base-line norms. Through a comparison of patient responses to established norms, the clinician can determine the scope and severity of cognitive impairments. Psychologists and neuropsychologists create batteries of standardized tests to answer specific referral questions. A typical battery consists of more than a dozen standardized tests and provides very specific data on a patients cognitive functioning.. What types of cases should I refer for neuropsychological testing? ...
Subtle cognitive decline (SCD) may represent a very early stage of objective cognitive impairment before mild cognitive impairment (MCI), with less neuronal damage and more functional reservation. Detecting individuals with SCD is imperative for dementia prevention and treatment. In this study, we aimed to compare the validations of three cognitive screening tests, Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment-Chinese Version (MoCA-CV), and Memory and Executive Screening (MES), in identifying subtle cognitive decline. A total of 407 individuals were recruited, including 147 cognitively normal controls (NC), 102 individuals with subtle cognitive decline (SCD) and 158 individuals with mild cognitive impairment (MCI) according to the operational neuropsychological criteria proposed by Jak and Bondis. All participants underwent standardized comprehensive neuropsychological tests and the three cognitive screening tests. Chi-square analysis was used to compare the cognitive performance
Psychometrics in neuropsychological assessment -- Norms selection in neuropsychological assessment -- History taking -- Test selection, test administration, and preparation of the patient -- Report writing and feedback sessions -- General cognitive functioning, neuropsychological batteries, and assessment of premorbid intelligence -- Achievement tests -- Executive functions -- Attention -- Memory -- Language tests -- Tests of visual perception -- Tests of somatosensory function, olfactory function, and body orientation -- Tests of motor function -- Assessment of mood, personality, and adaptive functions -- Assessment of response bias and suboptimal performance ...
Children, adolescents, and young adults who are having difficulties with learning and overall functioning may benefit from a neuropsychological evaluation. In addition, individuals with neurological/medical diagnoses or general developmental concerns would benefit from a neuropsychological evaluation.. For more information on the neuropsychological assessments offered at Psychology Resources, please click here.. For more information on Dr. Baruch Williams, Psychology Resources neuropsychologist, please read her biography.. ...
Background: Many genes and environmental factors linked to Alzheimers disease (AD) risk affect lipid metabolism or the cardiovascular system, strongly implicating cerebrovascular and metabolic dysfunction in AD pathogenesis. Although some PUFAs may improve cognitive function in aging individuals, it is still unclear how different PUFAs influence AD neuropathology and cognitive function.. Objective: To examine the influence of polyunsaturated fatty acid (PUFA) metabolism on AD-associated cognitive decline, we investigated the relationship between serum PUFA profile and neuropsychological test performance.. Methods: Cognitive functioning in patients with probable AD (n = 174, mean age 77.6 years) was examined using the Mini-Mental State Exam (MMSE) and clock drawing test (CDT). Serum samples were obtained for PUFA profile, including the eicosapentaenoic acid/arachidonic acid (EPA/AA) ratio, and measurement of brain natriuretic peptide (BNP) concentration. In the follow-up study, 47 subjects ...
Topamax(R) produces adverse effects on cognitive functions at rates of over 40% in subjects with epilepsy. These effects manifest as confusion, psychomotor slowing, difficulty with concentration/attention, difficulty with memory, speech or language and word-finding difficulties. Using computerized Neuropsychological Test Battery (CNTB) modules, measuring attention/concentration, verbal and visual memory, and working memory, as well as two paper and pencil processing speed tests: Symbol Digit Modalities Test (SDMT) and verbal associative fluency test (FAS), the novel extended release Topiramate formulation (SRx-502) was shown to be associated with both significantly reduced cognitive impairment and fewer reduced adverse events ...
A Compendium Of Neuropsychological Tests Administration - A Compendium Of Curiosities Volume Iii By Tim Holtz Idea Free Ebook Pdf Downloads hosted by Bianca Thompson on A Compendium of Neuropsychological Tests:
The objective of this study was to examine the association of chronotropic response (CR) and heart rate (HR) recovery- two indices of cardiovascular function within the context of a graded exercise test- with cognitive performance in a cognitively healthy, late-middle-aged cohort at risk for Alzheimers disease (AD). Ninety participants (age = 63.52±5.86 years; 65.6% female) from the Wisconsin Registry for Alzheimers Prevention participated in this study. They underwent graded exercise testing and a comprehensive neuropsychological assessment that assessed the following four cognitive domains: Immediate Memory, Verbal & Learning Memory, Working Memory, and Speed & Flexibility. Regression analyses, adjusted for age, sex, and education, were used to examine the association between CR, HR recovery, and cognition. We found significant associations between CR and cognitive performance in the domains of Immediate Memory, Verbal Learning & Memory, and Speed & Flexibility. In contrast, HR recovery was ...
OBJECTIVE: A subgroup of patients with Chronic Fatigue Syndrome (CFS) has cognitive impairments, reflected by deviant neuropsychological test performance. However, abnormal test scores can also be caused by suboptimal effort. We hypothesized that worse neuropsychological test performance and underperformance were related to each other and to a smaller reduction in fatigue, functional impairments, physical limitations and higher dropout rates following cognitive behavior therapy (CBT) for CFS. METHODS: Data were drawn from a previous trial, in which CFS patients were randomized to two conditions; 1) guided self-instruction and additional CBT (n=84) or 2) waiting period followed by regular CBT for CFS (n=85). Underperformance was assessed using the Amsterdam Short Term Memory Test (,84). To test neuropsychological test performance, the Symbol Digit Modalities Task, a simple reaction time task and a choice reaction time task were used. Interaction effects were determined between underperformance ...
The impact of heading on neuropsychological performance is a subject of controversy. In this experimental study, a controlled group design was used to investigate the possible effects of a short heading training session on neuropsychological performance. Ninety-one participants matched by age, sex, and intelligence were assigned to one of the following groups: A heading-training group, a placebo control group, and a waiting control group. All participants completed a neuropsychological test battery for attention and working memory (D2 Test, Benton Visual Retention Test, Paced Auditory Serial Addition Task Test). After 1 week, they received heading training, football (e.g., soccer) training without heading, or no training. Immediately after this training, the neuropsychological tests were conducted again. There was no neuropsychological deficit which could only be attributed to the heading training. However, within the heading group, women complained more about headache than men. Verf.-Referat ...
INTRODUCTION: Attention Deficit Hyperactivity Disorder (ADHD) and previous history of concussion (PHC) are being reported more frequently in college athletes; the presence of these co-morbidities and their effects on concussion assessment has been somewhat limited. PURPOSE: Determine if a relationship exists between ADHD and PHC and the effect of these co-morbidities on neuropsychological test scores. METHODS: This study was a retrospective cross-sectional between groups design. D-1 college athletes (N=1840, males N=1737, females N=103) with a mean age of 19.8+1.6 years completed a computerized neuropsychological test (ImPACT) to establish baseline assessment of concussion history during pre-participation physicals. Participants were divided into groups based upon self-reported diagnosis of ADHD and PHC. Self-report symptoms and ImPACT composite scores served as dependent variables. Comparisons of groups were calculated utilizing regression models and One-Way ANOVAs. All statistical analyses ...
TY - JOUR. T1 - Performance on tests of frontal lobe function reflect general intellectual ability. AU - Obonsawin, M. C.. AU - Page, J.. AU - Chalmers, P.. AU - Cochrane, R.. AU - Low, G.. AU - Crawford, John Robertson. PY - 2002. Y1 - 2002. N2 - Recent studies have indicated that performance tin tests of frontal lobe function are highly associated with general intellectual ability (g). Some authors have even claimed that the available evidence does not support a more specific account of frontal lobe function than to provide a general intellectual function for the performance of goal directed tasks. foe examined the relationship between performance on the WAIS-R (as a measure of g) and performance on standard tests of frontal lobe function in 123 healthy individuals. Our results demonstrate that in healthy individuals (i) performance on the most popular tests of frontal lobe function shares significant variance, and (ii) a large proportion of that shared variance is highly associated with ...
TY - JOUR. T1 - Lafora disease. T2 - Spectroscopy study correlated with neuropsychological findings. AU - Pichiecchio, Anna. AU - Veggiotti, Pierangelo. AU - Cardinali, Simonetta. AU - Longaretti, Francesca. AU - Poloni, Guy U.. AU - Uggetti, Carla. PY - 2008/7. Y1 - 2008/7. N2 - Purpose: To evaluate the metabolic changes both in grey and white matter in Lafora disease using proton magnetic resonance spectroscopy and to determine the possible correlation with the pattern of cognitive impairment. Methods: Five patients with Lafora disease and six healthy controls were included in the study. Patients underwent at the same time-point neuropsychological testing and 1[H]MRS, using PRESS sequences (TE=136 and 25 ms) positioned in the frontal and posterior cingulate gyrus cortexes and in the adjacent frontal and parietal white matter. Results: Neuropsychological testing showed in all patients a prevalent involvement of performance abilities-with partial sparing of verbal competences-and of executive ...
Priming studies indicate that when a word or concept is activated in memory, and then spoken, it will activate other words or concepts which are associatively related or semantically similar to it. This evidence suggests that the order in which words are produced in the fluency task will provide an indirect measure of semantic distance between the items generated. Data from this semantic version of the task have therefore been the subject of many studies aimed at uncovering the structure of semantic memory, determining how this structure changes during normal development, or becomes disorganized through neurological disease or mental illness. These studies generally make use of multiple fluency lists in order to make estimates of the semantic distance between pairs of concepts.[19] Techniques such as multidimensional scaling and hierarchical clustering can then be used to visualize the semantic organization of the conceptual space. Such studies have generally found that semantic memory, at least ...
Seniors who consumed around 150g of cooked mushrooms weekly performed better on neuropsychological tests and had a 50% reduced risk of mild cognitive impairment compared to age-matched healthy controls.. This study was not a clinical trial so it is hard to establish causation but the researchers did see a dose-dependent effect with 75g of cooked mushrooms weekly also decreasing the risk of mild cognitive impairment.. One potential compound in mushrooms that may have brain benefits is ergothioneine. It is a unique antioxidant and anti-inflammatory compound that also accumulates in mitochondria. Humans are unable to synthesize ergothioneine on their own but it is present in a variety of mushrooms.. ...
The significant degree of heterogeneity found within the OCD population has generated recent interest in identifying and establishing subtypes of the disorder. The current study sought to examine and compare the neuropsychological performance of two purported subtypes of OCD patients, those who exhibit tics and those who do not exhibit tics. A clinical sample of 20 patients with OCD, 10 patients in each group, was recruited through two outpatient treatment centers. Patients were assessed using the Wisconsin Card Sorting Test, the Rey-Osterrieth Complex Figure Test, and an adaptive decision making test. The effects of attention, intelligence, and depression were controlled for in analyses. Results indicate that OCD patients without tics demonstrate very specific neuropsychological deficits, whereas OCD patients with a history of tics demonstrate broader based deficits. With regard to executive functioning, the OCD group without tics demonstrated specific difficulty in shifting set, whereas the OCD group
TY - JOUR. T1 - Neuropsychological profile in parents of adult phenylketonuria patients. AU - Santangelo, Gabriella. AU - Piscopo, Fausta. AU - Santangelo, Franco. AU - Trojano, Luigi. PY - 2018/1. Y1 - 2018/1. N2 - Phenylketonuria (PKU) is a disorder caused by an inborn error of metabolism, causing cognitive and behavioral disorders when not treated. Heterozygotes (i.e., patients parents) were described with low verbal intelligence quotient, but no study systematically investigated cognitive functions in PKU parents. To obtain a neuropsychological profile in heterozygotes, we compared cognitive performance of heterozygotes and healthy controls (HC) on cognitive battery. Twelve heterozygotes and 14 HCs underwent standardized neuropsychological tasks assessing frontal/executive functions, memory, and visuospatial abilities. No significant difference between heterozygotes and HC was found on demographic aspects. Heterozygotes performed worse than HC on immediate verbal recall, on test assessing ...
TY - JOUR. T1 - Neuropsychological predictors of driving errors in older adults. AU - Dawson, Jeffrey D.. AU - Uc, Ergun Y.. AU - Anderson, Steven W.. AU - Johnson, Amy M.. AU - Rizzo, Matthew. PY - 2010/1/1. Y1 - 2010/1/1. N2 - Objectives: To identify neuropsychological factors associated with driving errors in older adults. Design: Cross-sectional observational study. Setting: Neuropsychological assessment laboratory and an instrumented vehicle on a 35-mile route on urban and rural roads. Participants: One hundred eleven older adult drivers (aged 65-89; mean age 72.3) and 80 middle-aged drivers (aged 40-64; mean age 57.2). Measurements: Explanatory variables included age, neuropsychological measures (cognitive, visual, and motor), and a composite cognitive score (COGSTAT). The outcome variable was the safety error count, as classified according to video review using a standardized taxonomy. Results: Older drivers committed an average of 35.8 ± 12.8 safety errors per drive, compared with an ...
Different clinical criteria for diagnosing dementia were compared in a sample of 69 patients with motor neurone disease (MND). Participants performances on a computerised battery of neuropsychological tests were evaluated to assess the usefulness of these tests in predicting dementia in MND. The results indicated that when diagnostic criteria for frontotemporal (FTD) were used as part of a questionnaire method of diagnosing dementia the incidence of dementia in MND was considerably greater than traditional estimates suggest. Through a series of logistic and multiple regressions the results demonstrated that neuropsychological test performance related well to diagnostic classifications of dementia. MND patients with a clinical diagnosis of dementia were likely to demonstrate impaired new learning; poor working memory and planning; slowness in information processing and rigidity in thinking. These features, which are typical of cases of FTD, suggest that the dementia of MND is usefully ...
TY - JOUR. T1 - Molecular markers of neuropsychological functioning and Alzheimers disease. AU - Edwards, Melissa. AU - Balldin, Valerie Hobson. AU - Hall, James. AU - OBryant, Sidney. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Background: The current project sought to examine molecular markers of neuropsychological functioning among elders with and without Alzheimers disease (AD) and determine the predictive ability of combined molecular markers and select neuropsychological tests in detecting disease presence. Methods: Data were analyzed from 300 participants (n=150, AD and n=150, controls) enrolled in the Texas Alzheimers Research and Care Consortium. Linear regression models were created to examine the link between the top five molecular markers from our AD blood profile and neuropsychological test scores. Logistical regressions were used to predict AD presence using serum biomarkers in combination with select neuropsychological measures. Results: Using the neuropsychological test with the least ...
TY - CONF. T1 - Attention! Keep away from pain - neuropsychological changes in a case of pathological pain. AU - Halicka, Monika. PY - 2017/6/23. Y1 - 2017/6/23. N2 - People with unilateral pathological pain can show inattention to the affected side of the body and space, reminiscent of hemispatial neglect following brain injury. However, in pathological pain this distortion is usually subtle and it is unclear which aspects of spatial processing are affected. I will present a case-study of one 65-year old, right-handed woman who presented to our lab with Complex Regional Pain Syndrome (CRPS) affecting her left arm and pronounced inattention. We assessed clinical symptoms, body representation and attention to body-, reaching-, far- and imagined space. The patients data were compared to cut-off scores for standard neuropsychological tests, and to data from 12 matched controls for experimental measures. We found that the patient had a distorted cognitive representation of her affected limb. ...
Results are presented as standard scores for the Indexes and as percentile categories of low, medium, and high risk of cognitive impairment for the Process Scores.. Useful Clinical Studies. KBNA is correlated with the Wechsler Abbreviated Scale of Intelligence™ (WASI™), providing valuable clinical information about the effect of general cognitive ability on KBNA subtests. KBNA is also correlated with a variety of commonly used neuropsychological tests, including the California Verbal Learning Test® (CVLT®), the California Verbal Learning Test®-Second Edition (CVLT®-II), and the Boston Naming Test.. Flexible Information. KBNA allows examiners to choose among a general overview of cognition by calculating Index Scores only, a detailed analysis of neurocognitive functioning by also calculating Process Scores, or a combination of both. The Process Scores help you break down an examinees performance into component processes, making it easier to identify strengths and weaknesses, reach a ...
The main objective of the study is to investigate the determinants of the quality of life in children and adults with Neurofibromatosis type 1 (NF1) and more particularly the specific impact of neuropsychological deficits. In fact, cognitive impairment is currently considered as one of the most pervasive features of this genetic disorder but its relationship with the worsening of quality of life found in this population has not been directly investigated to date.. Secondary objectives of this study are (i) to compare neuropsychological and quality of life measures between patients and healthy controls matched by age, gender and education level, (ii) to contrast neuropsychological deficits incidence between patients and controls, and (iii) to differentiate NF1 childrens self versus hetero-assessment of quality of life.. The main hypothesis of this study is that the neuropsychological impairment classically identified in this clinical population will be associated to the quality of lifes ...
The main objective of the study is to investigate the determinants of the quality of life in children and adults with Neurofibromatosis type 1 (NF1) and more particularly the specific impact of neuropsychological deficits. In fact, cognitive impairment is currently considered as one of the most pervasive features of this genetic disorder but its relationship with the worsening of quality of life found in this population has not been directly investigated to date.. Secondary objectives of this study are (i) to compare neuropsychological and quality of life measures between patients and healthy controls matched by age, gender and education level, (ii) to contrast neuropsychological deficits incidence between patients and controls, and (iii) to differentiate NF1 childrens self versus hetero-assessment of quality of life.. The main hypothesis of this study is that the neuropsychological impairment classically identified in this clinical population will be associated to the quality of lifes ...
article{96817e16-6337-4988-bfd0-9edbe7539476, abstract = {To address the hypothesis of brain dysfunction as a component of the multiple chemical sensitivity (MCS) syndrome, a neuropsychological battery comprising 8 tests was given to 17 Swedish MCS patients and 34 demographically matched controls. Across the 6 tests used as indicators of brain impairment, comprising a total of 17 test variables, the MCS group performed poorer only in a complex reaction time test (mean reaction time; p = 0.002; t test). Correction for self-ratings of mental distress and trait psychasthenia did not eliminate the deviation in the reaction time test. Because the results on most tests were within normal limits, brain impairment was not evidenced. However, the similar minor deviations in neurobehavioral tests observed in several studies of MCS patients indicate the need for a study on a larger sample of MCS cases.}, author = {Österberg, Kai and Örbaek, Palle and Karlson, Björn}, issn = {0908-4282}, language = ...
Repeated measurements of episodic memory are needed for monitoring amnestic mild cognitive impairment (aMCI) and mild Alzheimers disease (AD). Most episodic memory tests may pose a challenge to patients, even when they are in the milder stages of the disease. This cross-sectional study compared floor effects of the Visual Association Test (VAT) and the Rey Auditory Verbal Learning Test (RAVLT) in healthy elderly controls and in patients with aMCI or AD (N = 125). A hierarchical multiple regression analysis was used to examine whether linear or quadratic trends best fitted the data of cognitive test performance across global cognitive impairment. Results showed that VAT total scores decreased linearly across the range of global cognitive impairment, whereas RAVLT total scores showed a quadratic trend, with total scores levelling off for 90% of aMCI patients and 94% of AD patients. We conclude that the VAT shows few if any floor effects in patients with aMCI and mild AD and is therefore a ...
TY - JOUR. T1 - Cognitive impairments in multiple system atrophy. T2 - MSA-C vs MSA-P. AU - Kawai, Y.. AU - Suenaga, M.. AU - Takeda, A.. AU - Ito, M.. AU - Watanabe, H.. AU - Tanaka, F.. AU - Kato, K.. AU - Fukatsu, H.. AU - Naganawa, S.. AU - Kato, T.. AU - Ito, K.. AU - Sobue, G.. PY - 2008/4. Y1 - 2008/4. N2 - OBJECTIVE: We evaluated comprehensive neuropsychological tests and regional brain blood flow to compare cognitive dysfunction between two types of multiple system atrophy: predominant cerebellar ataxia (MSA-C) and predominant parkinsonism (MSA-P). METHODS: Twenty-one patients with MSA-C, 14 patients with MSA-P, and 21 age- and education-matched control subjects were subjected to neuropsychological tests and SPECT. The neuropsychological tests examined general cognition, verbal and visual memory, working memory, visuospatial and constructional ability, language, executive function, depression, and anxiety, while SPECT analysis examined brain perfusion. RESULTS: Patients with MSA-P ...
Participant evaluations included demographic information, medical history, neurologic examination including the United Parkinsons Disease Rating Scale to examine for extrapyramidal signs, medication/adherence history, DSM-IV-based substance abuse/dependence inventory, immunologic and virologic laboratory tests, and neuropsychiatric testing; as previously reported.27 The 80-minute neuropsychiatric test battery, adapted from the NorthEast AIDS Dementia Cohort, assessed multiple cognitive domains affected by HIV-1 and included the following: choice and sequential reaction time from the California Computerized Assessment Package, Rey Auditory Verbal Learning Test (RAVLT), Rey Osterreith Complex Figure (RCF) Copy and Recall, Trail Making tests A and B, WAIS-R Digit Symbol, Grooved Pegboard (dominant and nondominant hands), Verbal fluency test, Animal Naming, Boston Naming Test, the WAIS-R Digit Span (forward and backward), and Timed Gait. Depression symptomatology was assessed using the Beck ...
TY - JOUR. T1 - Clock drawing test ratings by dementia specialists. T2 - interrater reliability and diagnostic accuracy. AU - Nair, Anil K. AU - Gavett, Brandon E. AU - Damman, Moniek. AU - Dekker, Welmoed. AU - Green, Robert C. AU - Mandel, Alan. AU - Auerbach, Sanford. AU - Steinberg, Eric. AU - Hubbard, Emily J. AU - Jefferson, Angela. AU - Stern, Robert A. PY - 2010. Y1 - 2010. N2 - The authors conducted a study of clock drawing test scoring by dementia specialists to determine interrater reliability and diagnostic accuracy. The authors randomly assigned 25 clocks from each of six predetermined groups based on consensus diagnosis (cognitive comparison subjects, subjects with a memory complaint but with normal neuropsychological testing, subjects with probable and possible mild cognitive impairment, and subjects with possible and probable Alzheimers disease) to dementia specialists for blinded scoring using a binary yes/no impairment system and a 0-10 scale as subjectively determined by each ...
Objective: To examine the influence of different performance validity test (PVT) cutoffs on neuropsychological performance, post-concussion symptoms, and rates of neurocognitive disorder and postconcussional syndrome following mild traumatic brain injury (MTBI) in active duty service members. Method: Participants were 164 service members (Age: M = 28.1 years [SD = 7.3]) evaluated on average 4.1 months (SD = 5.0) following injury. Participants were divided into three mutually exclusive groups using original and alternative cutoff scores on the Test of Memory Malingering (TOMM) and the Effort Index (EI) from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): (a) PVT-Pass, n = 85; (b) Alternative PVT-Fail, n = 53; and (c) Original PVT-Fail, n = 26 ...
TY - JOUR. T1 - Neuropsychological functioning in stimulant-naive boys with hyperkinetic disorder. AU - Rhodes, Sinéad M.. AU - Coghill, David, R. AU - Matthews, Keith. PY - 2005. Y1 - 2005. N2 - Although children with hyperkinetic disorder and/or attention deficit hyperactivity disorder (ADHD) show disordered executive neuropsychological functioning, the nature of these changes remains controversial. Additionally, impairments in non-executive neuropsychological functioning have been relatively unexplored. Here, the authors describe the neuropsychological functioning of a sample of stimulant drug-naive boys with hyperkinetic disorder on a battery of neuropsychological tasks sensitive to impairments of both executive and non-executive functions. Method. Seventy-five stimulant drug-naive boys meeting diagnostic criteria for ICD-10 hyperkinetic disorder were compared with 70 healthy developing controls matched for age but not IQ on computerized tests of neuropsychological functioning from the ...
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1991 Gulf War (GW) veterans continue to experience debilitating cognitive and mood problems more than two decades following their return from deployment. Suspected causes for these cognitive complaints include additive and/or synergistic effects of the varying combinations of exposures to chemicals in theater, including pesticides and pyridostigmine bromide (PB) pills. This study was undertaken to address one of the key recommendations of the US Department of Defense Environmental Exposure Report on Pesticides, which was to conduct an epidemiological study to further evaluate the role of neurotoxicant exposures in the expression of central nervous system symptoms reported by GW veterans. This study evaluated the role of pesticides and/or PB in the development of chronic neuropsychological dysfunction in GW veterans. We examined the associations between self-reported measures of pesticide and PB exposures and performance on neuropsychological tests in a group of 159 GW-deployed preventative ...
22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an ...
Verbal fluency tests (VFTs) are widely used frontal lobe neuropsychological tests. They have been frequently used in various functional brain mapping studies. There are two versions of VFTs based on the type of cue: the letter fluency task (LFT) and the category fluency task (CFT). However, the fundamental aspects of brain connectivity across the frontotemporal regions during the VFTs have not been elucidated. In this study, we hypothesized that differences in cortical functional connectivity over the left and right frontotemporal regions may be observed by means of multichannel functional near-infrared spectroscopy (fNIRS) during the performance of LFT and CFT. Our results from fNIRS (ETG-4000) showed different patterns of brain functional connectivity during the two types of VFTs, which was consistent with the different cognitive requirements of each task. We demonstrate increased brain functional connectivity over the frontal and temporal regions during the LFT than during the CFT; these results are
In this book (see record 1995-97202-000), Derix contrasts various subcortical dementia syndromes with cortical dementias, primarily Alzheimers disease. She provides an extensive literature review of diseases affecting the subcortical structures of the brain; describes the clinical manifestations, pathology, and pathophysiology of these illnesses; and examines the results of studies concerning performance on neuropsychological tasks. In addition, she explores the reported cognitive deterioration in subcortical and cortical dementia in terms of a cognitive, neuropsychological model of information processing. (PsycINFO Database Record (c) 2017 APA, all rights reserved) ...
Disruptions in hot cognition, i.e., the processing of emotionally salient information, are prevalent in most neuropsychiatric disorders and constitute a potential treatment target. EMOTICOM is the first comprehensive neuropsychological test battery developed specifically to assess hot cognition. The aim of the study was to validate and establish a Danish language version and reference data for the EMOTICOM test battery. To evaluate the psychometric properties of 11 EMOTICOM tasks, we collected data from 100 healthy Danish participants (50 males, 50 females) including retest data from 49 participants. We assessed test-retest reliability, floor and ceiling effects, task-intercorrelations, and correlations between task performance and relevant demographic and descriptive factors. We found that test-retest reliability varied from poor to excellent while some tasks exhibited floor or ceiling effects. Intercorrelations among EMOTICOM task outcomes were low, indicating that the tasks capture different ...
Neuropsychological profile in a specific cohort of HIV patients infected postnatally: a cross-sectional study Silvia Riva,1,2 Ilaria Cutica,1 Gabriella Pravettoni1,3 1Department of Health Sciences, University of Milan, 2Department of Neuroscience, IRCCS, Istituto di Ricerche Farmacologiche "Mario Negri", 3European Institute of Oncology, Milan, Italy Abstract: HIV-associated neurocognitive disorders (HANDs) are one of the most important complications of HIV infection reported in the current literature. Although HANDs have been closely studied in vertically infected HIV populations or in specific subgroups such as drug abusers or homosexuals, they have been completely understudied in hemophilia patients with HIV, infected through transfusions postnatally. For this reason, it seemed interesting to evaluate the presence of HAND in this specific population. The aim of this work is to present a study protocol aimed at assessing the neuropsychological profile of HIV+ hemophilia patients compared
Objective: Mini-mental state examination, a nonspecific measure of global cognitive function, and the clock drawing test, a very concise and specific measure of cognitive function, are among the most widely used screening tests for cognitive dysfunction. The present research aimed to examine the correspondence between MMSE and CDT scores. Methods: A total of ...
OBJECTIVE The primary purpose of this article was to determine if cognitive abilities decline, remain unchanged, or modestly improve throughout the course of schizophrenic illness. METHOD Forty-two patients with a first hospitalization for schizophrenia or schizophreniform disorder and 16 normal comparison subjects had a battery of neuropsychological tests and a magnetic resonance imaging (MRI) brain scan at approximate yearly intervals for the first 2 to 5 years of illness. Summary rating scales for language, executive, memory, processing speed, and sensory-perceptual functions were constructed. RESULTS Patients with schizophrenia scored 1 to 2 standard deviations below normal comparison subjects on neuropsychological test measures during the course of the study. Patients exhibited less improvement than comparison subjects on measures of verbal memory. In general, improvement in positive symptoms over the time interval was associated with improvement in cognition. No changes in regional brain
ARE YOU CONSIDERING PSYCHOEDUCATIONAL OR NEUROPSYCHOLOGICAL TESTING FOR YOUR CHILD?. Focus Childrens Therapy Center offers a wide range of testing services at our center, in school and in a childs home. We specialize in providing school based evaluations including speech and language as well as occupational therapy evaluations. Additionally we also specialize in Psychoeducational and Neuropsychological testing for all students.. Recently there has been a high demand from schools and families requesting further information on neuropsychological testing. Our highly skilled team of therapists specializing in neuropsychology are here to support you. We have put together an informational overview below to enable you to best support and communicate to families and children under your care. I hope you find this tool useful.. Neuropsychological Evaluation. A Neuropsychological evaluation is a comprehensive assessment of cognitive and behavioral functions using a set of standardized tests and ...
In the current investigation, a prototype for the remote assessment of cognitive skills, the remote neuropsychological assessment (RNA) model, was proposed, and the development and validation of a computerized, Internet-based neuropsychological assessment measure was undertaken to demonstrate the utility and effectiveness of this untapped model of assessment delivery. The Remote Neuropsychological Assessment-Category Test (RNA-CT), a test of abstract concept formation administered via the World Wide Web (WWW), was developed and contrasted with a conventional, non-computerized version of the measure---the Booklet Category Test (BCT). Traditional and novel measurement variables from both measures were compared in a randomized group design of normal college-educated subjects in an attempt to demonstrate equivalence between the conventional assessment and RNA model. Comparison of the equivalence between administration types suggests significant convergence for total error, subtest error variables, and
Schizophrenia is characterized by neuropsychological deficits across many cognitive domains. Cognitive phenotypes with high heritability and genetic overlap with schizophrenia liability can help elucidate the mechanisms leading from genes to psychopathology. We performed a meta-analysis of 170 published twin and family heritability studies of ,800 000 nonpsychiatric and schizophrenia subjects to accurately estimate heritability across many neuropsychological tests and cognitive domains. The proportion of total variance of each phenotype due to additive genetic effects (A), shared environment (C), and unshared environment and error (E), was calculated by averaging A, C, and E estimates across studies and weighting by sample size. Heritability ranged across phenotypes, likely due to differences in genetic and environmental effects, with the highest heritability for General Cognitive Ability (32%- 67%), Verbal Ability (43%-72%), Visuospatial Ability (20%-80%), and Attention/Processing Speed ...
Neuropsychological testing evaluates cognitive function, including general intelligence, attention, memory span, judgment, and motor, sensory and speech ability. Tests can also be used to assess emotional stability, quality of language production, distractibility and other qualities. These tests can document impairments that can be used to diagnose specific neurological illness or damage. For example, a selective impairment in speech production with relative sparing of performance on other tests can suggest that brain injury is localized to one of several brain areas critical for speech production. Neuropsychological tests can also be used to diagnose dementia and certain kinds of psychological conditions Two of the many neuropsychological tests which are used to test memory abilities are the California Verbal Learning Test (CVLT) and the Sternberg Memory Scan ...
While there are many neurocognitive tests on the market today (Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT®), Automated Neuropsychological Assessment Metrics (ANAM), or Headminder Concussion Resolution Index (CRI) for example), there is no Gold Standard neurocognitive test to date. Having said that, the ImPACT® test was the first computerized neurocognitive test to receive FDA Approval2 and is currently the most widely used and valid neurocognitive test. During the ImPACT® test, the athlete takes the test before participation in sports. If they sustain a concussion or mild traumatic brain injury, then this test can be used to establish when the brain is ready for RTP. But wait; unfortunately, its not that easy. Neurocognitive tests, such as ImPACT®, are not as valid or specific for those with learning disabilities and attention deficit-spectrum disorders.3,4 Of the 6 composite scores of the ImPACT® test, those with learning disabilities and/or attention ...
Antipsychotics have at best small positive effects on cognitive performance. There is a lack of knowledge regarding the effects of antidepressants on cognitive functioning in these disorders. In the present study cognitive performance was investigated in relation to serum levels of antidepressants in persons with bipolar disorder and schizophrenia. Serum concentrations of escitalopram, citalopram and venlafaxine plus O-desmethylvenlafaxine were measured in a total of 187 participants with bipolar disorder (N = 74) or schizophrenia spectrum disorders (N = 113), and analyzed in relation to neuropsychological tests performance of verbal learning, verbal memory, attention, working memory, executive functioning and processing speed. Analyses were performed using linear regression adjusting for a range of confounders.. There was a significant positive association between the serum level of venlafaxine plus O-desmethylvenlafaxine and verbal memory (immediate recall: Logical Memory Test immediate recall ...
TY - JOUR. T1 - Neuropsychological tests norms above age 55. T2 - COWAT, BNT, MAE Token, WRAT-R Reading, AMNART, STROOP, TMT, and JLO. AU - Ivnik, Robert J.. AU - Malec, James F.. AU - Smith, Glenn E.. AU - Tangalos, Eric G.. AU - Petersen, Ronald C.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Age- (,55 years) and education-based norms are presented for eight neuropsychological tests: COWAT, BNT, MAE Token, WRAT-R Reading, AMNART, STROOP, TMT, and JLO. These data were obtained via several research projects that are known collectively as Mayos Older Americans Normative Studies (MOANS). While this normative information should prove useful for each test, the fact that these norms were simultaneously obtained from the same reference group should promote accuracy in the comparison of any persons performance on one test against his or her functioning on any other tests with MOANS norms. Finally, the unique features of this MOANS sample are reviewed. These features must be kept in mind when these norms are ...
The primary aim of the present study was to evaluate the efficacy and stability over time of a cognitive rehabilitation protocol (restorative and compensatory approach) in HIV/AIDS patients with HIV-associated Neurocognitive Disorder (HAND). At baseline, 32 HIV/AIDS patients (16 with and 16 without HAND) were assessed with a neuropsychological battery (i.e., pre-assessment) consisting of 22 tests covering eight cognitive domains. Then, the experimental group was administered over 4 months a cognitive rehabilitation protocol aimed at improving four cognitive domains by means of eight paper and pencil/computer-based exercises. The control group received guideline-adherent clinical care (i.e., standard of care). At the end of the cognitive treatment, both groups were re-administered the neuropsychological battery (i.e., post-assessment). Additionally, 6 months after post-assessment, the experimental group was given the same neuropsychological battery (i.e., follow up-assessment). In order to test the
OBJECTIVE: To compare and validate neurocognitive tests in the Harmonized Cognitive Assessment Protocol (HCAP) for the China Health and Retirement Longitudinal Study (CHARLS), and to identify appropriate tests to be administered in future waves of CHARLS.. METHODS: We recruited 825 individuals from the CHARLS sample and 766 subjects from hospitals in six provinces and cities in China. All participants were administered the HCAP-neurocognitive tests, and their informants were interviewed regarding the respondents functional status. Trained clinicians administered the Clinical Dementia Rating scale (CDR) to assess the respondents cognitive status independently.. RESULTS: The testing protocol took an average of 58 minutes to complete. Refusal rates for tests of general cognition, episodic memory, and language were less than 10%. All neurocognitive test scores significantly correlated with the CDR global score (correlation coefficients ranged from 0.139 to 0.641). The Mini-Mental State Examination ...
The largest, but most mysterious, sub-region of prefrontal cortex is the rostral PFC (RPFC). As a proportion of whole-brain volume, some have estimated the human RPFC to be twice as large as the corresponding region in the chimpanzee brain. Yet curiously, patients with damage restricted to the RPFC often perform well on standard neuropsychological tests, including classical tests of executive function such as the Wisconsin card sorting test. Instead, patients with damage to this region seem to have particular difficulty in real-world multitasking situations, such as organising a shopping trip when there are few strict constraints - participants are relatively free to organise their behaviour however they like - but there are also multiple instructions to be remembered, rules to be followed, and potential distractions in the environment. Recent accounts have focused on the role of RPFC in the most high-level human abilities, such as combining two distinct cognitive operations in order to ...
While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of specific cognitive domains after illness onset. This study investigates the longitudinal course of cognitive deficits four years after a first-episode of psychosis and the relationship of performance with clinical course and response to treatment. Twenty three individuals with psychotic illness, matched with 21 healthy volunteers, were assessed using the MATRICS Consensus Cognitive Battery at illness onset and 4years later. We also investigated the relationship between cognitive deficits and quality of life and clinical indices. Verbal learning and two measures of processing speed had marked poorer trajectory over four years compared to the remaining cognitive domains. Processing speed performance was found to contribute to the cognitive deficits in psychosis. Poorer clinical ...