9th Neuropharmacology Conference in Berlin, Germany during November 15-16, 2018. Meet Top Pharma Industry Professionals, Researchers, Scientists, Sponsors and Exhibitors from USA (America), UK, Europe, Asia, Middle East and earn CME Credits at Neuropharmacology Conferences and Neurology Conferences
Dr. Yina Ma is currently the director of Social & Affective NeuroPharmacology (SANP) Lab, Principal Investigator and full professor at State Key Laboratory of Cognitive Neuroscience and Learning, and IDG/McGovern Institute for Brain Research, Beijing Normal University. She obtained her Ph.D. degree in Cognitive Neuroscience at Peking University in 2012, and was a Research Scientist at Dartmouth College and Johns Hopkins University from 2012 to 2015. Integrating neuroscience techniques, pharmacological challenge, computational modeling and disorder models, her research group aims to elucidate the neurobiological mechanisms underlying social decision-making during interpersonal and intergroup interactions and to reveal how the mechanisms are altered. These findings have been published on high-profile journals such as Nature Neuroscience, PNAS, Molecular Psychiatry, Brain, Trends in Cognitive Sciences, Cerebral Cortex, Neuropsychopharmacology, British Journal of Psychiatry, etc. She is elected ...
This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.. ...
This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.. ...
Elsevier, the leading publisher of scientific, technical and medical information products and services, today announced that the Anxiety and Depression: 21st Neuropharmacology Annual Conference will take place in Virginia, USA on 10-11 November 2011 as a satellite to the 2011 Meeting of the Society for Neuroscience.
|p|La revue Neuropharmacology consacre son numéro du mois de mai 2013 aux traitements des troubles du neurodéveloppement.|br class=autobr /| 1. Cobb SR, Davies CH. (...)|/p|
PMID: 28495375 Komlodi Timea, Tretter Laszlo (2017) Neuropharmacology Abstract: Methylene blue (MB), a potential neuroprotective agent, is efficient in various neurodegenerative disease models. Beneficial effects of MB have been attributed to improvements in mitochondrial functions. Substrate-level phosphorylation (SLP) results in the production of ATP independent from the ATP synthase (ATP-ase). In energetically compromised mitochondria, ATP produced by SLP can prevent the reversal of the adenine nucleotide translocase and thus the hydrolysis of glycolytic ATP. The aim of the present study was to investigate the effect of MB on mitochondrial SLP catalysed by succinyl-CoA ligase. Measurements were carried out on isolated guinea pig cortical mitochondria respiring on α-ketoglutarate, glutamate, malate or succinate. The mitochondrial functions and parameters like ATP synthesis, oxygen consumption, membrane potential, and NAD(P)H level were followed online, in parallel with the redox state of MB. ...
This session will feature oral presentations from postdocs selected from the submitted abstracts as well as a talk by the winner of the Division for Neuropharmacology Early Career Award.
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CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Obsessive-compulsive disorder (OCD) is characterized by obsessions (intrusive thoughts) and compulsions (repetitive ritualistic behaviours) leading to functional impairment. Accumulating evidence links these conditions with underlying dysregulation of fronto-striatal circuitry and monoamine systems. These abnormalities represent key targets for existing and novel treatment interventions. However, the brain bases of these conditions and treatment mechanisms are still not fully elucidated. Animal models simulating the behavioural and clinical manifestations of the disorder show great potential for augmenting our understanding of the pathophysiology and treatment of OCD. This paper provides an overview of what is known about OCD from several perspectives. We begin by describing the clinical features of OCD and the criteria used to assess the validity of animal models of symptomatology; namely, face validity (phenomenological
ECNP in depth is a serie of interviews that ECNP is planning with key people in the field, looking at their work and what it says about the future of applied neuroscience. We hope you enjoy them.
The molecular and cellular mechanisms of neurological, neurodegenerative, and neuropsychiatric disorders are subjects of concentrated research. To these ends, a team of scientists with expertise in neurophysiology, neuropharmacology, biochemistry, epigenetics, and therapeutics development has been assembled to take a multidisciplinary approach to translate findings from basic research into novel therapeutics including stem cell therapies and gene therapies.The molecular and cellular mechanisms of neurological, neurodegenerative, and neuropsychiatric disorders are subjects of concentrated research. To these ends, a team of scientists with expertise in neurophysiology, neuropharmacology, biochemistry, epigenetics, and therapeutics development genomics and proteomics has been assembled to take a multidisciplinary approach to translate findings from basic research into novel therapeutics including stem cell therapies and gene therapies.. ...
Signal transduction refers to the processes by which intercellular signals such as neurotransmitters, neurotrophic factors, circulating hormones, and cytokines produce intracellular biochemical alterations that in turn modify neuronal functioning including the regulation of gene expression. Intercellular signals and their receptors, generally located in the neuronal plasma membrane, represent only a small amount of all information processing in the brain. An understanding of the complex biochemical mechanisms that operate inside ...
The brain controls bodily function and behavior through the motor system, the autonomic nervous system (Chapter 9), and hormones released by neuroendocrine neurons. Hormones are signaling molecules that reach their target cells by means of the bloodstream. They comprise three major classes: peptides, neurotransmitter-like small molecules such as epinephrine (adrenalin), and steroid-like molecules. Through its neuroendocrine system, the brain contributes to body homeostasis, regulates growth and maturation, and facilitates the bodys response to environmental stressors, illness, and injury. ...
Research is showing that there may be links between anxiety and related anxiety issues and how we respond to cannabinoids, like CBD, through our Endocannabinoid System (ECS). Here is a link to the journal article Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors. From the Abstract: In conclusion, our findings indicate that CBD…
Affiliation (Current):京都大学,医学研究科,医員, Research Field:Biological Sciences,Neurochemistry/Neuropharmacology,Neurochemistry/Neuropharmacology,Neuroscience in general,General medical chemistry, Keywords:グルタミン酸受容体,神経科学,蛋白質,glutamate receptor,ファージディスプレイ法,ユビキチンリガーゼ,代謝型グルタミン酸受容体,蛋白相互作用,NMDA受容体,メタボトロピック受容体, # of Research Projects:7, # of Research Products:6
Accumbens 0-64 2-8 30 >100 > 10 >20 1-6 3 22 > 100 >10 >20 Tyrosine hydroxylase activity was measured in tissue homogenates prepared as described by ZIVKOVIC et al. ( 1 9 7 4 ) . The enzyme activity was measured with saturating concentrations of tyrosine and with 0-3 mM pteridine cofactor (dimethyltetrahydropteridine). 932 A. CARENZI, D . L . CHENEY, E. COSTA, A. GUIDOTTI and G . RACAGNI Table 3. Action of opiates, ( + )-amphetamine and antipsychotics on the stimulation of the adenyl cyclase from rat striatum and nucleus accumbens by D A I C 50 (M) Striatum Drug Clozapine Haloperidol ( + )-Amphetamine Morphine Viminol R 2 4 χ 10 N. Effect of tricyclic antidepressant and chloropromazine on brain catecholamine system. In : Proceedings of the International Symposium on Antidepressant Drugs (GARATTINI, S. and BURKES, Μ. N . ) pp. 28-34. Excerpta Medica Foundation, N e w York. ROTH, R. , WALTERS, J. , M U R R I N , L . C. and MORGENROTH, V. H. (1975). D o p a m i n e neurons: role of impulse flow ...
Pharmacological agents are typically grouped according to their target diseases, chemical structures, or molecular mechanisms of action. Categorization of drugs according to their use in the...
主要利用现代生物物理学、神经电生理学、神经行为学、神经药理学及生理心理学手段,探讨意识、认知过程的起源、演化及其脑机制。目前主要进行啮齿类和非人灵长类猕猴的大脑前额叶认知功能的研究,探讨其功能异常与某些精神、神经疾病等的关系以及药物成瘾的心理戒断的脑机制。. We combined technologies of multiple disciplines, including modern biophysics, electrophysiology, neuroethology, neuropharmacology and psychology, to explore the origin, evolution and brain mechanism of consciousness and cognitive processes. We are now mainly focused on the cognitive function of prefrontal lobe in rodent and non-human primate macaques and its involvement in certain mental and neurological diseases. We are also interested in the brain mechanism of psychological withdrawal from drug addiction. ...
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Science Citation Index Expanded (SciSearch®), Journal Citation Reports/Science Edition, InCites, Neuroscience Citation Index®, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, MEDLINE/PubMed/PubMed Central, Europe PMC, Scopus, EMBASE, Chemical Abstracts Service/SciFinder, ChemWeb, Google Scholar, PsycINFO, ProQuest, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, Index Copernicus, J-Gate, CNKI Scholar, Suweco CZ, TOC Premier, EBSCO, Ulrichs Periodicals Directory and JournalTOCs.. ...
Numerous studies dissecting the basic mechanisms that control sleep regulation have led to considerable improvement in our knowledge of sleep disorders. It is now well accepted that transitions between sleep and wakefulness are regulated by complex neurobiologic mechanisms, which, ultimately, can be …
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Allan, K J and Waters, M and Ashton, D G and Patterson-Kane, J C (2006) Meningeal cholesterol granulomas in two meerkats (Suricata suricatta). VETERINARY RECORD, 158 (18). pp. 636-637. Bate, C and Kempster, S and Last, V and Williams, A (2006) Interferon-gamma increases neuronal death in response to amyloid-beta(1-42). JOURNAL OF NEUROINFLAMMATION, 3. p. 7. Bate, C and Kempster, S and Williams, A (2006) Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death. NEUROPHARMACOLOGY, 51 (2). pp. 173-181. Bate, C and Kempster, S and Williams, A (2006) Prostaglandin D-2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. NEUROPHARMACOLOGY, 50 (2). pp. 229-237. Blake, D P and Hesketh, P and Archer, A and Carroll, F and Shirley, M W and Smith, A L (2006) Eimeria maxima: the influence of host genotype on parasite reproduction as revealed by quantitative real-time PCR. International Journal for Parasitology, 36 (1). pp. ...
The authors note in their introduction that the book is based on a course given to graduate and medical students. And, in fact, it is essentially a compilation of lectures appropriate to the student seeking an introduction to humoral transmitters in the central nervous system. Its scope is confined to what the authors believe to be the current understanding of these neurotransmitters, especially in terms of their biochemistry.. Two thirds of the book is devoted to the putative neurohumors. For each, there is information about methods of assay, localization and metabolic life cycle in the central nervous system, and concise ...
Affiliation:首都大学東京,大学院理工学研究科,助教, Research Field:Neurochemistry/Neuropharmacology,Neurochemistry/Neuropharmacology,Functional biochemistry, Keywords:Cdk5,タンパク質,酵素,リン酸化,CIN85,Protein kinase,Proteasome,発生・分化,アルツハイマー,リサイクリング, # of Research Projects:3, # of Research Products:16
In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical curiosities, to occupy a prominent position in research on the causes and treatment of several major CNS disorders. The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their pharmacological profiles: one is a selective agonist at receptors sensitive to NMDA, whereas the other is a selective antagonist at low concentrations at the strychnine-resistant glycine modulatory site associated with the NMDA receptor. It has been argued that these agents cannot be of physiological or pathological relevance because their normal extracellular concentrations, in the nanomolar range, are at least 3 orders of magnitude lower than those required to act at NMDA receptors. This is a facile argument, however, that ignores at least two possibilities. One is that both quinolinate and kynurenate may be present in very high concentrations ...
The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP) ...
The optomotor following response, a behavior based on movement detection was recorded in the fruitfly Drosophila melanogasterbefore and after the injection of picrotoxinin, an antagonist of the...
The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP) ...
The module will provide training in high-throughput and high-content screening technologies to post-graduate students. The course delivers training through a mixture of lectures, practical classes, tutorials, assignments and a training workshop. Students will gain theoretical and practical knowledge of high-throughput and high-content screening and develop proficiency in a range of data analysis techniques. The course will be delivered through the Biomedical Sciences Screening Core Facility at NUI Galway. The facility is fully equipped to deliver all aspects of the course. The course will be open to research MSc students and PhD students in biomedical sciences (College of Science, College of Medicine and other relevant Colleges ) subject to capacity and approval of the Module owner ...
The module will provide training in high-throughput and high-content screening technologies to post-graduate students. The course delivers training through a mixture of lectures, practical classes, tutorials, assignments and a training workshop. Students will gain theoretical and practical knowledge of high-throughput and high-content screening and develop proficiency in a range of data analysis techniques. The course will be delivered through the Biomedical Sciences Screening Core Facility at NUI Galway. The facility is fully equipped to deliver all aspects of the course. The course will be open to research MSc students and PhD students in biomedical sciences (College of Science, College of Medicine and other relevant Colleges ) subject to capacity and approval of the Module owner ...
Can you pick the MOAs? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by uncsom
The POD speaker today was an ophthamologist who studies how to prevent retinal damage or detachment in prematurely born infants. Basically, when premature infants are put into incubators with high levels of oxygen, it affects the development of blood vessels in their eyes. The blood vessels dont grow as much as they should because the babys eyes dont need them in such a high oxygen environment. But as soon as the baby is taken out of the incubator and now is in a normal oxygen environment, the blood vessel growth in its eyes becomes excessive and abnormal, leading to retinal detachment and other problems. That happens because relative to the incubator, the babys new environment is hypoxic (too low in oxygen). So these researchers are trying to prevent abnormal blood vessel growth and retinal detachment, and they are having some success. Pretty neat stuff ...
Outline Definitions Seizure vs. Epilepsy Antiepileptic drugs History of antiepileptic drugs (AEDs) AEDs: Molecular and cellular mechanisms Cellular mechanisms of seizure generation Pharmacokinetic principles Drug metabolism enzymes AED inducers AED inhibitors AED Serum Concentrations Definitions: Therapeutic Index, Steady state Pharmacodynamic interactions Comparative pharmacokinetics of old vs. new AEDs Pharmacokinetics in special populations Metabolic changes of AEDs AEDs and drug interactions Adverse effects Acute vs. chronic Idiosyncratic Case Studies American Epilepsy Society 2011
Alzheimers Disease In Vitro Models - Aβ induced toxicity, Aβ peptide formation/screening, Aβ aggregates, Hypothermia, Tau aggregation in vitro.
Following his graduation in medicine, Paul Grof took his psychiatric training and became specialized in psychiatry in 1962. He worked as a research psychiatrist in the Psychiatric Research Institute in Prague, and as a fellow in psychoendocrinology of affective disorders in West Germany. In the fall of 1968 Dr. Grof was recruited as research psychiatrist and faculty member at McMaster University, Canada.. Between 1974 and 1977 he helped develop and run Affective disorder Clinics at the Sunnybrook Medical Center at the University of Toronto, and several other Canadian universities. Dr. Grof spent 1977 and 1978 as a Visiting Scientist at the National Institute of Mental Health in Washington, initially in a clinical neuropharmacology branch with Dennis Murphy and later in the psychobiology branch with Fred Goodwin.. In l982 Dr. Grof became Director of Research and Education at the Hamilton Psychiatric Hospital, a teaching hospital of McMaster University where he expanded research activities in ...
0026]1. Okuno E, Nishikawa T, M Nakamura, (1996) Kynurenine aminotransferases in the rat. Localization and Characterization. Recent Advances in Tryptophan Research, edited by Graziella Allegri Filipini et al., Plenum Press, New Your, 1996.2. B. Kepplinger, H. Baran, A. Kainz, H. Ferraz-Leite, J. Newcombe and P. Kalina (2005) Age-related increase of kynurenic acid in human cerebrospinal fluid: Positive corratio with IgG and Sa-microglobulin changes. Neurosignals, 14(3), 126-135.3. Kepplinger B, Baran H, Kainz A, Zeiner D, Wallner J (2006) Cerebrospinal Fluid of Multiple Sclerosis patients exert significantly weaker inhibition of Kynurenine Aminotransferase I activity in rat liver homogenate. Multiple Sclerosis 2006; 12:S1-S228, P4964. H. Baran, B. Kepplinger, M. Draxler and H. Ferraz-Leite (2004) Kynurenic acid metabolism in rat, piglet and human tissues. In European Society for Clinical Neuropharmacology by ed L. Battistin, International Proceedings MEDIMOND S.r.1. E505R9004, 227-231.5. H. ...
Djaldetti Ruth; Giladi Nir; Hassin-Baer Sharon; Shabtai Hertzel; Melamed Eldad (November-December 2003). "Pharmacokinetics of Etilevodopa Compared to Levodopa in Patients With Parkinsons Disease: An Open-label, Randomized, Crossover Study". Clinical Neuropharmacology. 26 (6): 322-326. doi:10.1097/00002826-200311000-00012. PMID 14646613 ...
16. Mohammad Nasehi, SamanehAmin-Yavari, Mohaddeseh Ebrahimi-Ghiri, MohammadTorabi-Nami, Mohammad-Reza Zarrindast. The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task. European Neuropsychopharmacology. 2015. 17. Ghasemi R, Zarifkar A, Rastegar K, Maghsoudi N, Moosavi M. Insulin protects against A beta-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. 2014.. 18. Farrokhi MR, Nikoo Z, Gholami M, Hosseini Kh. Comparison between Acrylic Cage and Polyetheretherketone (PEEK) Cage in Single-Level Anterior Cervical Discectomy and Fusion: A Randomized Clinical Trial. J Spinal Disord Tech. 2015.. 19. Farrokhi MR, Lotfi M, Masoudi MS, Gholami M. Effects of methylene blue on postoperative low-back pain and functional outcomes after lumbar open discectomy: a triple-blind, randomized placebo-controlled trial.. ...
Biogenic amine neurotransmitters are important modulators of the central nervous system. Studies on the roles of the histaminergic system have revealed that it regulates many key brain functions. It has also been implicated to be involved in many brain disorders. Modulation of histamine signalling may thus provide an option for the treatment of these conditions. Due to its relatively recent discovery, many unanswered questions about the histaminergic system remain. In this thesis, I studied the neuropharmacology of the histaminergic system using the zebrafish as a model of the vertebrate brain. In the first study, the effect of acute ethanol on the histaminergic and dopaminergic systems was analysed. The mRNAs of enzymes synthesizing dopamine and histamine were upregulated by a short ethanol exposure in a dose-dependent manner. The morphology of the histaminergic and dopaminergic systems was unaltered by ethanol treatment, suggesting that the changes observed were localized to cells that produce ...
PTB Reports [Pharmacology, Toxicology and Biomedical Reports] - It is an international, peer-review, open access, online journal publishing research articles, review articles, clinical case reports and recent trends in experimental and clinical pharmacology, toxicology and Biomedicine. It covers clinical pharmacokinetics, biochemical pharmacology, clinical biochemistry, molecular biology, analytical toxicology, psychopharmacology, neuropharmacology, cardiovascular and renal pharmacology and other systemic pharmacology.. ...
PTB Reports [Pharmacology, Toxicology and Biomedical Reports] - It is an international, peer-review, open access, online journal publishing research articles, review articles, clinical case reports and recent trends in experimental and clinical pharmacology, toxicology and Biomedicine. It covers clinical pharmacokinetics, biochemical pharmacology, clinical biochemistry, molecular biology, analytical toxicology, psychopharmacology, neuropharmacology, cardiovascular and renal pharmacology and other systemic pharmacology.. ...
... is discussing topics about the latest research work in the field of neuroscience, neurology, neurosurgery and neuropharmacology. Also you will find here topics about medical design
Major Areas of Research: Addiction: UT Health San Antonio is home to the Addiction Research, Treatment & Training Center of Excellence (ARTT). Students apply a variety of approaches to the study of addiction including behavioral pharmacology, biochemistry, electrochemistry, electrophysiology, molecular pharmacology, and neuropharmacology. Human laboratory studies and clinical
The main areas of research of the Institute for Pharmacology and Toxicology are neuropharmacology, neurobiology and neuro-immunopharmacology. With our research we are contributing to the facultys two main research areas neurobiology and immunology.. Using state-of-the-art technologies including behavioral pharmacology, molecular biology, protein chemistry, cell biology and microscopy we are interested in the molecular mechansims of neuron-astrocyte communication for synapse formation and synaptic plasticity, the mechanisms of addiction and tolerance, the biological underpinnings of schizophrenia and the functional role of opioide and cannabinoide receptors and their ligands for the interplay of the nervous and immune system.. ...
The Department of Pharmacology, in the UC Irvine School of Medicine, is home to research and teaching in the fields of: molecular pharmacology, cellular regulation, neuropharmacology, cardiovascular pharmacology and drug development.
Secondary, our researches aim the development of psychiatric treatment. Our Neuropharmacology team has been focusing on genetic association with the interindividual differences in drug responses. The team has reported the association between genetic polymorphisms of drug metabolizing enzyme, CYP, and neurotransmitter receptors and both drug efficacy and adverse effects. Besides, our research teams in clinical psychiatry also toward the development of structured rehabilitation program for recovery in schizophrenia, return to work program in mood disorder, and intervention for suicide attempters at critical care units. ...
Neuroscience Blog is discussing topics about the latest research work in the field of neuroscience, neurology, neurosurgery and neuropharmacology. Also you will find here topics about medical design