The study creates autologous gene-modified T cells against prostate specific membrane antigen (PSMA, unrelated to PSA) (designer T cells) by ex vivo modification of patient T cells. T cells are collected by leukopheresis, transported to the RWMC cGMP Cell Manipulation Core and transduced with retrovirus containing a chimeric antigen receptor (CAR) that is expressed on the modified cells. This CAR links specificity of an antibody against PSMA with signaling domains of the T cell and redirects the recognition of the T cells to engage and kill prostate cancer cells anywhere in the body. These are administered at a dose of 10^10 with randomization to either low or moderate Interleukin 2 given by CI (continuous infusion) for one month following the T cell infusion. Subsequent subjects will receive 10^11 cells with Interleukin 2 at either low or moderate dose, in a non randomized manner, depending upon the outcome of the prior cohort. Prior to T cell infusion, all subjects will receive ...

An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.

An automated screening system and method for cytological specimen classification in which a neural network is utilized in performance of the classification function. Also included is an automated microscope and associated image processing circuitry.

TY - JOUR. T1 - Belief networks for modelling and assessment of environmental change. AU - Varis, Olli. PY - 1995. Y1 - 1995. KW - articial intelligence, bayesian networks, eia, water mangement, water quality, environment. KW - articial intelligence, bayesian networks, eia, water mangement, water quality, environment. KW - articial intelligence, bayesian networks, eia, water mangement, water quality, environment. M3 - Article. VL - 6. SP - 439. EP - 444. JO - Environmetrics. JF - Environmetrics. SN - 1180-4009. IS - 5. ER - ...

When a patient is in urgent need of treatment, for a condition like cancer, a fast method to produce diagnosable material from the laboratory is desirable. CellientTM uses alcohol-fixation and enables diagnosis the same day the sample is received, while the standard method using formaldehyde takes over 48 hours before a diagnosis can be provided. CellientTM is fast and reduces human errors, but the affect it has on immunocytochemistry is not fully established. The purpose of this work was to validate CellientTM for clinical use. The validation was to establish whether cytological specimens prepared using the CellientTM gave comparable results to specimens prepared using the standard method. Specimens were prepared using both methods before immunocytochemical staining with antibodies was performed. Validation was performed using a parallel analysis of patient specimens using the CellientTM method and the standard method and then immunocytochemically staining the material with antibodies targeting ...

TY - JOUR. T1 - Primitive neuroectodermal tumor of the kidney with level II inferior vena cava involvement.. AU - Cary, K. Clint. AU - Sundaram, Chandru P.. PY - 2008/12. Y1 - 2008/12. N2 - Primitive neuroectodermal tumor of renal origin, PNET, is extraordinarily rare and often lethal. Here we present a case of renal PNET managed successfully by radical nephrectomy, caval thrombectomy and retroperitoneal node dissection.. AB - Primitive neuroectodermal tumor of renal origin, PNET, is extraordinarily rare and often lethal. Here we present a case of renal PNET managed successfully by radical nephrectomy, caval thrombectomy and retroperitoneal node dissection.. UR - http://www.scopus.com/inward/record.url?scp=61549106330&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=61549106330&partnerID=8YFLogxK. M3 - Article. C2 - 19046499. AN - SCOPUS:61549106330. VL - 15. SP - 4431. EP - 4432. JO - Canadian Journal of Urology. JF - Canadian Journal of Urology. SN - 1195-9479. IS - ...

TY - JOUR. T1 - Gangliosides and neutral glycolipids in ependymal, neuronal and primitive neuroectodermal tumors. AU - Yates, Allan J.. AU - Franklin, Teresa K.. AU - McKinney, Paula. AU - Collins, Raymond. AU - Comas, Theodore. AU - Boesel, Carl P.. AU - Pearl, Dennis K.. N1 - Funding Information: This work was supported by grants from The National Cancer Institute UO1-CA50910, P30 CA 16058, the NCI Cooperative Human Tissue Network, The Department of Pathology and the College of Medicine, and Public Health, OSU.. PY - 1999. Y1 - 1999. N2 - Neutral glycolipid and ganglioside compositions were determined on 11 ependymal tumors, 12 medulloblastomas, 6 other neuronal tumors of the brain, 4 peripheral neuroblastomas, 1 cerebral primitive neuroectodermal tumor (PNET), and 1 PNET of the thoracic wall. Within the group of tumors that can demonstrate neuronal phenotypes, there was an association between the degree of neuronal differentiation usually demonstrated by these tumors and the proportions of ...

A primitive, or undifferentiated, nerve cell is a cell in the brain or central nervous system that doesnt have a specific function. Primitive cells are often malignant (meaning they are often cancerous), and start to grow out of control. Doctors call the resulting tumors primitive neuroectodermal tumors, or PNETS.. Types of PNETs include medulloblastoma, posterior fossa PNET, supratentorial PNET, and pineoblastoma. All of these tumors are able to metastasize (spread) through the cerebrospinal fluid that surrounds the brain and the spinal cord.. PNET symptoms generally depend on the size and location of the tumor, but common symptoms include:. ...

Introduction: Primitive neuroectodermal tumor (PNET) of kidney is a rare clinical condition. We report a young girl with PNET of kidney. Case Presentation: A 14-year-old female presented with chronic flank pain. Imaging studies revealed a huge renal mass with left renal vein thrombosis. Histopathological findings were consistent with PNET, which was later confirmed by immunohistochemistry and she received adjuvant chemotherapy. Conclusions: PNET is a rare clinical condition in urology and it should be considered in young patients with a renal mass, especially when it is huge. Treatment plan includes radical nephrectomy along with neoadjuvant chemotherapy. © 2017, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences.. ...

Shares many features with Ewing tumor and Extraosseous Ewings sarcoma. Primitive Neuroectodermal Tumors are rare cancers, also found in soft tissue and bone.

A 16-year-old boy presented with an unusual case of a supratentorial, extraaxial small round blue cell tumor of the central nervous system, which was most likely a primitive neuroectodermal tumor (PNET). Preoperative computed tomography and magnetic resonance imaging showed a large multistage hematoma in the left central region. Intraoperatively, a small, superficial tumorous lesion was found between the sagittal sinus and a large cortical vein hidden by the hematoma. The histological diagnosis was PNET. This tumor is one of the most aggressive intracerebral tumors, not only in children, so treatment strategies must be early, profound, and interdisciplinary. This case represents an important example of atypical extraaxial appearance of this lesion, which should be considered in the differential diagnosis of cortical or subcortical hemorrhage, since complete resection of this lesion is critical for the successful treatment and outcome. ...

Primitive neuroectodermal tumour of the kidney with vena caval and atrial tumour thrombus: a case report. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

neuroectodermal tumor of the ovary Open references Novel treatment of a central type, primitive neuroectodermal tumor of the ovary with (...)

Monoclonal antibodies (mAbs) recognizing the disialoganglioside II3(NeuAc)2GgOse3Cer (GD2) were produced by immunizing mice with the GD2-expressing neuroblastoma cell line LAN-1 and a prefusion boost with purified GD2 coupled to Salmonella minnesota. Two IgM mAbs were isolated which demonstrated hig …

Shop our T Shirts department today at Ragazzi Clothing to find designer T shirts from Barbour, Penfield, C.P. Company and Paul & Shark.

Click here for neuroectodermal tumor pictures! You can also find pictures of Pancreatic cancer, lymphomas, Lymphoma, Lung Cancer.

This is a single institutional data review of renal PNET patients. All patients were treated with uniform chemotherapy protocols. Baseline clinical characteristics, histological features, treatment details ad survival outcomes were collected from case files. Overall survival (OS) was calculated from time of diagnosis to death due to any cause. ...

In vivo proton MR spectroscopy provides useful information in clinical differentiation between PNETs and common brain tumors in adults.

Case Reports in Surgery is a peer-reviewed, Open Access journal that publishes case reports related to all aspects of surgery. Topics include but are not limited to oncology, trauma, gastrointestinal, vascular, and transplantation surgery.

DISEASE CHARACTERISTICS:. Histologically proven AR and ESFT which includes: Classical, atypical and extraosseous Ewings sarcoma, primitive peripheral neuroectodermal tumors, peripheral neuroepithelioma, primitive sarcoma of bone, and ectomesenchymoma.. Confirmed presence of tumor-specific infusion protein by documented RT-PCR which corresponds to one of the tumor specific peptides available for vaccination.. Measurable tumor.. No prior or current CNS metastases.. PRIOR/CONCURRENT THERAPY:. Arm A patients:. May be enrolled on the protocol for the first phase in the absence of RT PCR documentation of a tumor-specific fusion protein which corresponds to one of the tumor-specific peptides available for vaccination. However, RT PCR documentation at the time of tumor recurrence must occur prior to administration of immunotherapy. At time of initial tumor diagnosis, prior to any cytoreductive therapy.. Arm B patients:. Tumor recurrence occurring during or after receiving at least first line ...

In an article entitled Ependymoblastoma: Dear, Damned, Distracting Diagnosis, Farewell! published online in Brain Pathology, authors Alexander R. Judkins (UPenn) and David W. Ellison (St. Judes, Memphis) adapt a line from Alexander Popes poem A Farewell to London (1715) for their title. Judkins and Ellison conclude the following: We believe that ependymoblastoma as a diagnosis is neither precise nor specific and that it is time once and for all to retire this diagnosis from the lexicon of neuropathology. For now, the World Health Organization tumor classification sytem continues to recognize ependymoblastoma as a distinct nosologic entity. These neoplasms are often large, supratentorial, and usually connect to the ventricles. Although there is no definitive feature of ependymoblastoma, the ependymoblastomatous rosette is a histologic characteristic that has been used in making the diagnosis. A photomicrograph of such a rosette from the Judkins & Ellison article is shown. In this picture, ...

Retinoblastoma is a malignant primitive neuroectodermal tumour (PNET) arising in the retina. It is the commonest intraocular tumour of childhood; the average age at presentation is 18 months. CT demonstrates a contrast-enhancing retrolental mass...

What code would be used for a neuroectodermal tumor, supratentorial, of the left frontal lobe? I am a little confused because a neuroectodermal tumor

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...

An analysis of a series of cell lines has indicated that the expression of myoD, myogenin and desmin can be detected inbona fide RMS. With the exception of the American Type Culture Collection lines A204, A673 and Hs729T and the St. Jude-derived cell line Rh1, expression of all three markers was readily apparent by Western analysis. We suspect that the extended time in culture of the former cell lines may have resulted in the down-regulation of these myogenic genes. Rh1 was originally diagnosed as an embryonal RMS, but it is now thought to be a tumor of primitive neuroectodermal origin (PNET). Because Rh1 was isolated from the patient in 1985 beforemyoD and myogenin antibodies were available, the primary diagnosis was determined from histopathology using conventional reagents. A recent immunohistochemical study of tumor samples using frozen sections essentially confirmed that all RMS expressedmyoD and that this gene product was undetectable in normal tissues, including both adult and fetal ...

The diverse biological role of nerve growth factor (NGF) as a necessary modulator of neuroectodermal cell survival, proliferation and differentiation has been previously well described in both normal and neoplastic cell lines. However, recent studies demonstrate that neuroectodermal tumors, such as neuroblastoma, contain genetic alterations that result in limited secretion of active NGF, as well as expression abnormalities of its receptors TrkA and p75. To better define the differential effects of exogenous and endogenously synthesized NGF, the in vitro response of wild-type and genetically engineered neuroblastoma cells was investigated. Replication-defective NGF-expressing retroviral vectors were prepared using the calcium phosphate co-precipitation method and used to transfect SK-N-BE(2)C cells. Presence of the NGF cDNA was confirmed by RT-PCR, and secretion of NGF into the conditioned media by western immunoblotting. NGF transfection resulted in decreased cell proliferation as determined by ...

Mit der Neuerung der Website hat Dark-Sky Switzerland auch ein neues Logo in Auftrag gegeben. Ziel war es, in einem klaren, schlichten Signet die grundsätzlichen Aufgaben von DSS zum Ausdruck zu bringen, was nach Meinung des Teams äusserst gut gelungen ist. Hinter dem neuen Logo steckt Designer und Grafiker Manuel Kurth (Bild) von Airblast. Der 32-jährige Künstler, der unter anderem für das Trendmagazin „Seventh Sky arbeitete, ist seit 1996 in Lausanne als Designer tätig. Das Logo gestaltete der Künstler für Dark-Sky Switzerland grosszügigerweise kostenlos.Sagen Sie uns Ihre Meinung zur neuen Website respektive zum neuen Logo. Ausgewählte Aussagen werden wir in einer der nächsten News publizieren.. ...

2014 Elsevier Inc. All rights reserved.Primary tumors of the nervous system pose unique clinical challenges given their location and biology. This chapter summarizes the common molecular genetic alterations associated with these tumors, with particular emphasis on the genomic alterations associated with neurofibromatosis, astrocytomas, glioblastomas, oligodendrogliomas, neuroectodermal tumors, schwannomas, and meningiomas ...

Central nervous system primitive neuroectodermal brain tumors (CNS PNET for short) are a particularly rare but nasty form of cancer that leaves patients with a poor prognosis, particularly when very young children are stricken. But scientists at The University of Nottingham in the U.K. have identified genetic markers that they think will lead to vital new diagnostics for the condition.

The proposed deterministic approach:. -based on the use of a two-step expertise methodology already in place and operational for French PWR, the 3D3P method (triple diagnosis triple prognosis, IRSN-EDF). -supported by existing fast-running source term evaluation tools (PERSAN, IRSN) that will also be extended to all European reactors. -The proposed probabilistic approach:. -based on the use of the existing Bayesian Belief Network (BBN) tool (RASTEP, SSM). The key is to produce a specific ranking of plausible scenarios from a pre-computed database of European reference accident scenarios and the BBN tool RASTEP. -complemented by automatic post-processing tools being able to rank scenarios based on external constraints such as the protection of the surrounding population. -These two methods will be developed:. - extending the BBN capabilities from static to dynamic representation of inferences for complex network. -including deterministic information coming from specific models or severe accident ...

See how people just like you are living with supratentorial primitive neuroectodermal tumor. Learn from their data and experience.

Up to 40% incidence of metastasis: Staging the extent of disease in supratentorial PNET is critical for devising an appropriate treatment plan. Metastatic dissemination of supratentorial embryonal tumors within the CNS is observed in 5-39% of patients (1, 4, 8, 9). Staging of supratentorial PNETs can be done on the basis of the criteria proposed by Chang et al. (23) as follows: M0 (no tumor dissemination beyond the local site), M1 (positive CSF cytology), M2 (intracranial dissemination), M3 (intraspinal dissemination), and M4 (systemic dissemination ...

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...

Abstract BACKGROUND: Primitive neuroectodermal tumors (PNETs) comprise a group of aggressive, poorly differentiated embryonal tumors occurring in central nervous system as well as in peripheral locations. Primary cerebellopontine angle (CPA) PNET is an extremely rare entity. It is important to have knowledge of this pathology and to be able to differentiate it from other commonly occurring CPA tumors, such as vestibular and trigeminal schwannomas. This distinction is essential because of the difference in the overall treatment plan and prognosis. CASE DESCRIPTION: This report describes a case of a young male presenting with diplopia and numbness of face; magnetic resonance imaging showed a CPA mass. With a provisional diagnosis of trigeminal schwannoma, the patient underwent surgery. Histopathology provided a diagnosis of PNET. CONCLUSION: We discuss the importance of recognizing this rare condition and how this entity differs from the commonly occurring tumors.

TY - JOUR. T1 - Primitive neuroectodermal tumor with peritoneal metastasis through a ventriculoperitoneal shunt. AU - Yamamoto, Yoshihiro. AU - Kunishio, Katsuzo. AU - Suga, Masakazu. AU - Sunami, Norio. AU - Yamamoto, Yuji. AU - Sonobe, Hiroshi. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1989. Y1 - 1989. N2 - A 13-month-old boy admitted with lethargy and hydrocephalus was found to have a right thalamic mass. Ventricular drainage was instituted, and the tumor mass was reduced by partial resection and local irradiation. A ventriculoperitoneal shunt was then placed. However, the tumor recurred 16 months later, with extensive ventricular seeding and peritoneal metastasis through the shunt tube. The child died 22 months after onset. Histological study of surgical specimens of the primary tumor and autopsy specimens of the brain and peritoneal metastatic tumors revealed poorly differentiated, small, round cells with numerous mitotic figures. In addition, autopsy ...

Expression of insulin-like growth factor I (IGF-I) mRNA by some tumor cell lines of neuroectodermal origin has been described. To further explore the significance of IGF-I mRNA expression in these tumors, a more extensive analysis was performed. Most (9 of 10) neuroectodermal tumor cell lines with a t(11;22) translocation (primitive neuroectodermal tumor [PNET], Ewings sarcoma, esthesioneuroblastoma) expressed IGF-I mRNA, whereas 0 of 15 cell lines without the translocation (PNET, neuroblastoma) expressed IGF-I. Furthermore, inasmuch as all neuroblastoma (12 of 12) cell lines examined expressed IGF-II RNA, the pattern of IGF expression could distinguish between these closely related tumors. CHP-100, a PNET cell line with the t(11;22) translocation, was shown to secrete both IGF-I protein and an IGF binding protein, IGFBP-2. This cell line also expressed the type I IGF receptor mRNA, and blockade of this receptor by a monoclonal antibody (alpha IR3) inhibited serum-free growth. These data ...

Fingerprint Dive into the research topics of Primitive neuroectodermal tumor (Extraskeletal Ewings Sarcoma) of the kidney with vena caval tumor thrombus. Together they form a unique fingerprint. ...

1. Schiavetti A et al. Nutritional status in childhood malignancies. Nutr Cancer. 2002; 44(2): 153-5. Abstract. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12734061&dopt=Abstract. 2. Bakish J et al, Evaluation of dietetic intervention in children with medulloblastoma or supratentorial primitive neuroectodermal tumors. Cancer. 2003 Sep 1; 98(5): 1014-20.. 3. Quillin, Patrick Ph.D. R.D. Beating Cancer With Nutrition. 3rd. edition. Bookworld Services. 2001.. 4. Wojtaszek C and Kochis L. Nutritional Screening and Assessment: An Overview. Integrating Nutrition Into Your Cancer Program. March/April 2002. www.accc-cancer.org/publications/ScreeningAssess.pdf. 5. National Institute of Health. Helping Your Child. Accessed March 2, 2004. http://win.niddk.nih.gov/publications/child.htm 6. Kurtzwei, Paula. Daily Values Encourage Healthy Diet. FDA. http://www.fda.gov/fdac/special/foodlabel/dvs.html. Accessed March 15, 2004.. 7. NIH. Children Failing to Meet National ...

Search for abbreviations and long forms in lifescience, results along with the related PubMed / MEDLINE information and co-occurring abbreviations.

PNETs are aggressive embryologic tumors with a poor prognosis and are divided in central and peripheral types. Although peripheral PNETs spread early to bones, lymph nodes, lung and liver, a leptomeningeal spread, as in this case, is extremely rare.

TY - JOUR. T1 - The potential for complete and durable response in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery. AU - Dahlborg, Suellen A.. AU - Petrillo, Annie. AU - Crossen, John R.. AU - Roman-Goldstein, Simon. AU - Doolittle, Nancy D.. AU - Fuller, Kristi H.. AU - Neuwelt, Edward A.. PY - 1998. Y1 - 1998. N2 - PURPOSE: Radiographic tumor response and survival were evaluated in the pediatric and young adult population with germ cell tumor, primary CNS lymphoma, or primitive neuroectodermal tumor receiving intra-arterial carboplatin- or methotrexate-based chemotherapy with osmotic blood-brain barrier disruption (BBBD). PATIENTS AND METHODS: Thirty-four patents with histologically confirmed germ cell tumor (n = 9), primary CNS lymphoma (n = 9), or primitive neuroectodermal tumor (n = 16) were treated at the Oregon Health Sciences University from August 1981 through April 1995. Ages ranged from 1 to 30 years (mean, 18 years). Prior treatments ...

The MYC proto-oncogene, a member of a family of highly related genes that includes MYCN and MYCL, encodes a nuclear phosphoprotein involved in the transcription of genes central to regulating the cell cycle (51) , cellular proliferation (52) , apoptosis (53) , and embryonic development and differentiation (54) . MYC proteins form heterodimers with Max, which is also a helix-loop-helix leucine zipper protein. MYC/Max heterodimers bind to specific DNA sequences located in the transcriptional control region of target genes and alter the transcription of these target genes by transactivation or transrepression.. MYC expression is normally tightly regulated throughout the cell cycle but may become deregulated or activated, contributing to malignant transformation (55) . Dysregulation of MYC has been implicated in the pathogenesis of a variety of human neoplasms, including Burkitts lymphoma (reviewed in Ref. 56 ), breast carcinoma (57) , colon adenocarcinoma (58) , lung carcinoma (59) , and prostate ...

Children develop a different group of sarcomas to the adult population. These include rhabdomyosarcoma, Ewing sarcoma/Peripheral Neuroectodermal Tumour (PNET), and osteosarcoma.. ...

BA is a novel antineoplastic agent with cytotoxicity against melanoma and neuroectodermal tumor cells. Here, we report that BA triggers an apoptotic cascade in human malignant glioma cells as well. BA-induced apoptosis of glioma cells involves sequentially new protein synthesis, formation of reactive oxygen species, and caspase processing. In detail, we show that BA toxicity depends on new protein but not mRNA synthesis, suggesting that translation of preexisting mRNA mediates BA toxicity. Caspase 8 and 3 activation are critical steps in the killing cascade triggered by BA because cell death ensues whenever caspase activation is detected. Furthermore, pharmacological (PBN, NAC, DEVD-CHO) or genetic (BCL-2) manipulations that inhibit apoptosis do so at the level of, or upstream of, caspase activation. Cytotoxic, cytokine-resistant glioma cells do not exhibit cross-resistance to BA, suggesting that caspase activation is independent of interactions of endogenous CD95/CD95L or related pairs of death ...

Rare tumors that share similar features, but some are in the bone and some in the soft tissue. They have the same abnormalities in their DNA and have similar proteins that are rarely found in other types of cancers. They also believe these 3 cancers develop from the same type of normal cells in the body. The three cancers are called Ewings sarcoma, Extraosseous (outside bone) Ewing (EOE), and Primitive Neuroectodermal Tumor (PNET).

A study in Pediatrics suggests that pregnant women who eat grain products fortified with folic acid may also be helping to decrease some types of childhood cancer. Nutrients such as folic acid and other vitamins are commonly added to products we buy at the store such as bread and cereal-a process referred to as fortification.. To explore whether kids born to women exposed to folic acid-fortified food sources have lower cancer risk, researchers looked at the incidence of childhood cancers in kids up to four years old during the time period before food was fortified with folic acid and after 1996 when the US Food and Drug Administration required that all enriched grain products be fortified with folic acid.. Results showed that the rates of certain types of childhood cancers did, in fact, decrease after folic acid was added to foods, including the rates of Wilms tumors, which affect the kidney; primitive neuroectodermal tumors that affect the nervous system; and ependymomas, which affect the brain ...

1. Bouchard, D., Morriset, D., Bourbonnais, Y., Tremblay, GM. Comprehensive analysis of HE4 expression in normal and malignit human tussues. Mod Pathol, 2006, 63, p. 847-853. 2. Campa, MJ., Wang, MZ., Howard, B., et al. Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin A as potential molecular targets in nonsmall cell lung cancer. Cancer Res, 2003, 63, p.1652-1656. 3. Condeelis, J., Pollard, JW. Macrophages: obligate partners for tumor cell migration, invasion and metastasis. Cell, 2006, 124, p. 263-266. 4. Das, R., Hammamieh, R, Neil, R., Melhem, M. Expression pattern of fatty acid binding proteins in human and carcinoma prostate cells and tissues. Clin Cancer Res, 2001, 7, p. 1706-1715. 5. de Bont, JM., den Boer, ML., Kros, JM., et al. Identification of novel biomarkers in pediatric primitive neuroectodermal tumors nad ependymomas by proteome wide analysis. J Neuropathol Exp Neurol, 2007, 66, p. 505-516. 6. DeSouza, L., Diehl, G., Rodriques, MJ., et ...

Primitive neuroectodermal tumor of the posterior fossa: medulloblastoma: evaluation of the proliferative index by means of monoclonal antibody Mib-1, its prognostic correlation and therapeutics implications ...

Context: Care of a child having colostomy has not been institutionalized for a long time for economic and administrative reasons. After stoma formation, stoma care has to be provided to the child by caregivers at home. Hence, caregivers need to be provided with ongoing education and support, commencing from preoperative teaching to discharge from the hospital and home care. Aims: The aims of this study were to develop video-based learning resource material and to evaluate its effectiveness in terms of knowledge and skill attainment by caregivers. Settings and Design: The study design was time series, one group pretest and post test. This was conducted among 30 caregivers attending pediatric surgery outpatients and indoor departments of a tertiary level care center. Materials and Methods: A video teaching program (VTP) related to pediatric colostomy was developed and used to teach the caregivers about colostomy care. Pretested and validated knowledge questionnaire, observational checklist, and ...

This paper proposes a novel, algorithm-independent approach to optimizing belief network inference. rather than designing optimizations on an algorithm by algorithm basis, we argue that one should use an unoptimized algorithm to generate a Q-DAG, a compiled graphical representation of the belief network, and then optimize the Q-DAG and its evaluator instead. We present a set of Q-DAG optimizations that supplant optimizations designed for traditional inference algorithms, including zero compression, network pruning and caching. We show that our Q-DAG optimizations require time linear in the Q-DAG size, and significantly simplify the process of designing algorithms for optimizing belief network inference ...

The role of β-amyloid (Aβ) in the pathogenesis of Alzheimers disease (AD) is still considered crucial. The state of Aβ aggregation is critical in promoting neuronal loss and neuronal function impairment. Recently, we demonstrated that Acetylcholine (ACh) is neuroprotective against the toxic effects of Aβ in the cholinergic LAN-2 cells. In biophysical experiments, ACh promotes the soluble Aβ peptide conformation rather than the aggregation-prone β-sheet conformation. In order to better understand the biological role of ACh in AD, we studied the effect of Aβ on the phosphorylation of the cytosolic phospholipase A2 (cPLA2) in the TB neuroectodermal cell line, which differentiates toward a neuronal phenotype when cultured in the presence of retinoic acid (RA). We chose the phosphorylated form of cPLA2 (Ser505, Phospho-cPLA2) as a biomarker to test the influence of ACh on the effects of Aβ in both undifferentiated and RA-differentiated TB cells. Our results show that TB cells are responsive ...

To the Editor.-Previously, we described two unrelated children with a new neuroectodermal syndrome,1-3 the major features of which included early onset migrator

Shop women t shirts and designer t shirts for Women Online. Buy Active Ribbed Cropped Tank Top for Women online at forever 21. Free Shipping, COD & Easy returns | 29731505

Diagnostics of ependymoblastoma (costs for program #205757) ✔ University Hospital Bonn ✔ Department of Oncology, Hematology, Rheumatology and Immunoncology ✔ BookingHealth.com

Resection of ependymoblastoma (costs for program #217727) ✔ University Hospital Marburg UKGM ✔ Department of Neurosurgery ✔ BookingHealth.com

Im afraid too that immunostaining for CDs is extremely difficult if not impossible, we make a lot of experiments in determining optimal fixation procedure for immunodetection of CDs and other antigens in human cytological specimens and we found as some other investigators that drying of the cells before fixation is detrimental for many antigens especially for surface antigens! it is true that you can detect some robust antigens like CK even in smears previously stained with Giemsa, but this is exception.. Maybe you should try with microwave pretreatment or you can ask clinicians to use spray fixative for fixing the smear or to prepare you the cells suspension.. hope this helps ...

Anti-Rat HRP-DAB Cell & Tissue Staining Kit from R&D Systems,R&D Systems Cell and Tissue Staining Kits are intended for localization of antigens in a broad range of histological and cytological specimens. These kits may be used with primary IgG antibodies manufactured by either R&D Systems or by other vendors. Briefly, detection is based on the formation of,biological,biology supply,biology supplies,biology product

The population-based mortality of melanoma has increased dramatically, ∼4% per year in the United States and ,20-fold since 1930, with ,60,000 new cases and ,8,000 deaths by 2009. In terms of numbers, another neuroectodermal tumor, small cell lung cancer, far exceeds melanoma as cause of death (25,000 per year) and is also GD3+ and a suitable target of therapy and for which no effective treatment currently exists (24). Further GD3+ malignancies include glioma, neuroblastoma, and others that could similarly be attacked by this strategy (3).. There is no standard curative treatment for advanced melanoma, which remains poorly responsive to chemotherapy, biotherapy, and radiotherapy (25). However, melanoma is one of the most immunoresponsive of human cancers and has served as prototype for the development of a number of different immunotherapies (26). Immunotherapy of melanoma typically uses one or several strategies: antitumor antibody, TILs, cytokines, vaccines (peptide and dendritic cell), and ...

There are comments on PubPeer for publication: Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors (2009)

Before joining PPD in 2009, Dr. Kaucic was a senior director in oncology clinical development at MedImmune AstraZeneca. There, she led product development teams for several biologics compounds, including monoclonal antibodies, biospecific antibodies and antibody conjugates.. Earlier in her career, Dr. Kaucic was a staff pediatric oncologist and senior investigator at Childrens National Medical Center in Washington, D.C., where she established the institutions first hematopoietic stem cell transplantation laboratory, served as an attending physician in oncology and conducted NIH-funded research in signal transduction in human neuroectodermal tumors. ...

• Ganglioneuromas are neuroectodermal tumors that are found in diverse anatomic sites, but they are very uncommon in the colon. We observed a patient with parti

The nervous system is the most common site for the development of solid neoplasms in childhood. Neuroblastoma represents a tumor developing at peripheral sites from primitive neuroectodermal cells...

A decade ago, Hinton, LeCun, and Bengio conspired to bring them back. Neural nets had a particular advantage compared with their peers: While they could be trained to recognize new objects-supervised learning, as its called-they should also be able to identify patterns on their own, much like a child, if left alone, would figure out the difference between a sphere and a cube before its parent says, This is a cube. If they could get unsupervised learning to work, the researchers thought, everyone would come back. By 2006, Hinton had a paper out on deep belief networks, which could run many layers deep and learn rudimentary features on their own, improved by training only near the end. They started calling these artificial neural networks by a new name: deep learning. The rebrand was on ...