A 45-year-old man presented with 3 months of progressive right hand weakness. Examination showed mild atrophy and weakness of the right hand, and absent tendon reflexes. Cerebrospinal fluid contained 0.42 g/l protein (normal ,0.45) and 1 lymphocyte/mm3. Electrodiagnostic studies revealed a multifocal motor neuropathy (MMN) with partial conduction blocks and severe denervation in the muscles of the right hand (figure 1). Sensory nerve conduction studies were normal. Charcot-Marie-Tooth disease, distal demyelinating polyneuropathy associated … ...

TY - JOUR. T1 - Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. AU - Greene, Douglas A.. AU - Arezzo, Joseph C.. AU - Brown, M. B.. PY - 1999/8/11. Y1 - 1999/8/11. N2 - Objective: To determine whether the aldose reductase inhibitor (ARI) zenarestat improves nerve conduction velocity (NCV) and nerve morphology in diabetic peripheral polyneuropathy (DPN). Methods: A 52-week, randomized, placebo-controlled, double-blinded, multiple-dose, clinical trial with the ARI zenarestat was conducted in patients with mild to moderate DPN. NCV was measured at baseline and study end. Contralateral sural nerve biopsies were obtained at 6 weeks and at the studys end for nerve sorbitol measurement and computer-assisted light morphometry to determine myelinated nerve fiber density (number of fibers/mm2 cross-sectional area) in serial bilateral sural nerve biopsies. Results: Dose-dependent increments in sural nerve zenarestat level and sorbitol suppression were ...

TY - JOUR. T1 - Sural sensory action potential identifies diabetic peripheral neuropathy response to therapy. AU - Vinik, Aaron I.. AU - Bril, Vera. AU - Litchy, William J.. AU - Price, Karen L.. AU - Bastyr, Edward J.. PY - 2005/11/1. Y1 - 2005/11/1. N2 - Identifying patients with diabetic peripheral neuropathy (DPN) amenable to therapy is a challenge. To determine whether the amplitude of the sural sensory nerve action potential (sural SNAP) reflects the severity of DPN, an analysis was performed on 205 patients with DPN, identified by an abnormal vibration detection threshold (VDT), who were enrolled in a multinational clinical trial investigating ruboxistaurin (RBX) mesylate. Nerve conduction velocity and response amplitude and latency were measured and compared. VDT was significantly lower in those with preserved sural SNAPs (n = 128) than in those in whom they were absent (n = 77; 21.5 vs. 22.7 JND units, P = 0.002). Thus, preserved sural SNAP denoted less severe DPN. Logistic regression ...

Tailoring is one of the major occupations adopted by skilled people with lower socioeconomic status and education level in Nepal. Nepal is one of the under developed countries in South Asia and the use of new technologies and innovations are out of access for people living in this country [1, 2]. Most of the people associated with tailoring occupation are still using mechanical sewing machine as an alternative of new technology for tailoring [3].. Somatic nerve conduction studies (NCS), which specifically measure the conduction velocity, latency and amplitude of the neurological response following electrical stimulation of peripheral nerve, was applied to assess neural functions. Nerves of lower limbs including common peroneal nerve are exposed to chronic stress imposed by chronic paddling and vibration generated by operation of mechanical sewing machine [4].. Nerve conduction studies are an essential part of the work-up of peripheral neuropathies. Many neuropathic syndromes can be suspected on ...

Home , Papers , TREK-1 and TRAAK Are Principal K Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves. ...

Fingerprint Dive into the research topics of Selective Effects of Potassium Elevations on Glutamate Signaling and Action Potential Conduction in Hippocampus. Together they form a unique fingerprint. ...

A resource for neurologists, neurology residents, medical students on a neurology rotation, and people interested in neurology or neuroscience. Review questions to help you study for the Neurology boards or RITE exam. Helpful PDA medical software.

Fingerprint Dive into the research topics of Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Together they form a unique fingerprint. ...

Electrodiagnostic studies are an important component of the evaluation of patients with suspected peripheral nerve disorders. The pattern of findings and the features that are seen on the motor and sensory nerve conduction studies and needle electromyography can help to identify the type of neuropathy, define the underlying pathophysiology (axonal or demyelinating), and ultimately help to narrow the list of possible causes. This article reviews the electrodiagnostic approach to and interpretation of findings in patients with peripheral neuropathies.

Dexterity impairments caused by carpal tunnel syndrome (CTS) make working and daily activities challenging. We aimed to investigate: i) the relationship between dexterity and nerve conduction studies (NCS) in workers with classic symptoms presentation; ii) the ability of the Functional Dexterity Test (FDT) to discriminate different levels of CTS severity as classified by NCS; iii) the diagnostic accuracy of a clinical battery composed of the FDT, Phalens test and Tinels sign. In a convenience sample of individuals diagnosed with CTS, we correlated FDT net scores with the NCS-based classification by means of Spearmans (rho) test. Discriminative ability of the FDT was assessed by ANOVA, and a ROC curve determined cutoff thresholds. Sensitivity, specificity, and likelihood ratios (LRs) were used to investigate the diagnostic accuracy of the clinical battery. Data from 180 hands were collected. The FDT was significantly correlated (rho = 0.25, p | 0.001) with NCS. The FDT was able to discriminate

Electromyography, or EMG, involves testing the electrical activity of muscles. Often, EMG testing is performed with another test that measures the conducting function of nerves. This is called a nerve conduction study. Both tests are usually performed at the same time.. Muscular movement involves the action of muscles and nerves and needs an electrical current. This electrical current is much weaker than the one in your household wiring. In some medical conditions, the electrical activity of the muscles or nerves is not normal. Finding and describing these electrical properties in the muscle or nerve may help diagnose your condition. EMG may aid with the diagnosis of nerve compression or injury such as carpal tunnel syndrome, nerve root injury such as sciatica, and with other problems of the muscles or nerves ...

OBJECTIVE:. To identify peripheral nerve abnormalities in hereditary spastic paraplegia (HSP) due to mutations in the spastin gene (spastic paraplegia 4, SPG4) using standard nerve conduction (NCS) and novel tests of axonal excitability.. METHODS:. Eleven patients with known mutations in spastin were assessed with NCS for the upper and lower limbs, and axonal excitability testing on the median nerve.. RESULTS:. Standard nerve conduction studies revealed a sensorimotor neuropathy in two patients. Excitability studies on median motor axons showed an isolated abnormality (increased strength-duration time constant), but those on sensory axons were normal in nine patients with normal routine nerve conduction studies.. CONCLUSIONS:. Peripheral neuropathy occurs in HSP patients with SPG4 mutations, but axonal excitability studies provide limited additional evidence for subclinical peripheral nerve dysfunction, and add little further to standard nerve conduction studies.. SIGNIFICANCE:. The features of ...

BACKGROUND: To inform the clinical management of patients with suspected carpal tunnel syndrome (CTS) and case definition for CTS in epidemiological research, we explored the relation of symptoms and signs to sensory nerve conduction (SNC) measurements. METHODS: Patients aged 20-64 years who were referred to a neurophysiology service for investigation of suspected CTS, completed a symptom questionnaire (including hand diagrams) and physical examination (including Tinels and Phalens tests). Differences in SNC velocity between the little and index finger were compared according to the anatomical distribution of symptoms in the hand and findings on physical examination. RESULTS: Analysis was based on 1806 hands in 908 patients (response rate 73%). In hands with numbness or tingling but negative on both Tinels and Phalens tests, the mean difference in SNC velocities was no higher than in hands with no numbness or tingling. The largest differences in SNC velocities occurred in hands with extensive

October 2013 Enrollment Update: The healthy control enrollment has been filled and is now closed. The study is still enrolling eligible infants with SMA.. Aim 1. To establish the validity of putative physiological SMA biomarkers in the immediate postnatal period. A longitudinal, natural history examination of physiological markers of muscle innervation will be performed in healthy and SMA infants. The first week of life is the ideal first time point, with visits occurring at scheduled visits up to the age two. Compound motor action potential (CMAP) amplitude and electrical impedance myography (EIM) will be examined and will be correlated with motor function. Each of these is associated with muscle innervation and provides information on the number and function of lower motor neurons in the spinal cord, the cellular target of SMA therapeutic interventions. This trial will establish the natural history of these putative SMA biomarkers as the disease evolves in affected infants. Moreover, our ...

TY - JOUR. T1 - Electrophysiologic study of spraymen exposed to insecticide Lambda- cyhalothrin. AU - Arunodaya, G. R.. AU - Kumar, K. R.. AU - Swamy, H. S.. AU - Murugendrappa, M. V.. PY - 1997. Y1 - 1997. N2 - Lambda-cyhalothrin is a potent insecticide which acts by prolonging the duration of opening of sodium channels in neurons. While it is being used in several countries, no extensive neurophysiologic study of toxic effects in humans is available. We performed multimodality electro-physiologic studies in 15 spraymen in the age range of 19-48 yrs. before and 3-5 days after the exposure to this insecticide, with a view to detect any neurotoxic manifestation. Facial nerve conduction, blink response, repetitive stimulation test and visual, auditory and somatosensory evoked potentials were normal. Six subjects had mild changes in peripheral nerve conduction parameters. Comparison of mean values of the various nerve conduction parameters before and after the exposure did not reveal any ...

ACE inhibition and/or blocking of the angiotensin II receptor are recognized as first-line treatment for nephropathy and cardiovascular disease in diabetic patients. However, little information is available about the potential benefits of these drugs on diabetic neuropathy. We examined vascular and neural activity in streptozotocin-induced diabetic rats that were treated for 12 weeks with enalapril, an ACE inhibitor, or l-158809, an angiotensin II receptor blocker. A prevention protocol (group 1) as well as three intervention protocols (treatment was initiated after 4, 8, or 12 weeks of diabetes [groups 2, 3, and 4, respectively]) were used. Endoneurial blood flow and motor nerve conduction velocity (MNCV) were impaired in all groups of untreated diabetic rats. In group 1, treatment of diabetic rats with enalapril or l-158809 partially prevented the diabetes-induced decrease in endoneurial blood flow and MNCV. In groups 2-4, intervention with enalapril was more effective in reversing the ...

TY - JOUR. T1 - Peripheral nerve energy metabolism in experimental diabetic neuropathy. AU - Low, Phillip A.. AU - Yao, Jeffrey K.. AU - Kishi, Yutaka. AU - Tritschler, Hans J.. AU - Schmelzer, James D.. AU - Zollman, Paula J.. AU - Nickander, Kim K.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Peripheral nerve has low energy demands at rest and when maximally stimulated. Coupled with the relatively high energy substrates available, it is more resistant to ischemia acid anoxia than brain. Diabetic peripheral nerve, by virtue of its enhanced energy stores, and chronic hypoxia, has an increased resistance to ischemic conduction failure, and subsists proportionately more than tissues such as brain on anaerobic metabolism. Since anaerobic metabolism is very inefficient, however, a reduction in energy substrates can increase the risk of fiber degeneration. Glucose uptake into peripheral neural tissues (sciatic; L5 dorsal root ganglion; superior cervical ganglion) are markedly reduced. α-Lipoic acid dose- ...

Results 138 POEMS patients and 69 matched CIDP controls were compared. POEMS patients demonstrated length dependent reduction in compound muscle action potentials, low conduction velocities, prolonged distal latencies and prolonged F wave latencies. Compared with CIDP controls, POEMS patients demonstrated: (1) greater reduction of motor amplitudes, (2) greater slowing of motor and sensory conduction velocities, (3) less prolonged motor distal latencies, (4) less frequent temporal dispersion and conduction block, (5) no sural sparing, (6) greater number of fibrillation potentials in a length dependent pattern and (7) higher terminal latency indices (TLI). TLI ≥0.38 in the median nerve demonstrated a sensitivity of 70% and specificity of 77% in discriminating POEMS from CIDP. ...

OBJECTIVE: The present study has examined the effect of vitamin E, the principal modulator of free radical activity, on electrophysiological parameters in patients with diabetic peripheral sensorimotor polyneuropathy, matched for duration of disease and metabolic control. RESEARCH DESIGN AND METHODS: A total of 21 subjects with type 2 diabetes were enrolled in this double-blind randomized placebo-controlled study (vitamin E, 11 patients; placebo, 10 patients). Patients were randomly assigned to receive either 900 mg vitamin E or placebo for 6 months. The average dietary vitamin E consumption of the subjects was similar during the study. The main outcome measure was the electrophysiological tests assessing nerve conduction. Fasting plasma glucose, HbA1, postprandial plasma glucose, and electrophysiological parameters in the basal state and after 6 months of treatment were studied. RESULTS: Glycemic indexes did not show any significant changes during the study, whereas nerve conduction improved ...

Slightly Reduced Nerve Conduction Velocities Symptom Checker: Possible causes include Hypergonadotropic Hypogonadism - Partial Alopecia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

0170]While particular aspects of the present subject matter described herein have been shown and described, it will be apparent to those skilled in the art that, based upon the teachings herein, changes and modifications may be made without departing from the subject matter described herein and its broader aspects and, therefore, the appended claims are to encompass within their scope all such changes and modifications as are within the true spirit and scope of the subject matter described herein. Furthermore, it is to be understood that the invention is defined by the appended claims. It will be understood by those within the art that, in general, terms used herein, and especially in the appended claims (e.g., bodies of the appended claims) are generally intended as open terms (e.g., the term including should be interpreted as including but not limited to, the term having should be interpreted as having at least, the term includes should be interpreted as includes but is not ...

Careful intraoperative monitoring. Regional anesthesia is not contraindicated; complete information about the risks involved has to be clearly expressed by the physician and understood by the patient/parents. However, there is no impact on the progression of the disease. Similar to most cases of Friedreich Ataxia, somatosensory evoked potential intraoperative monitoring during scoliosis surgery should be impossible. Slow peripheral nerve conduction velocities make monitoring of neuromuscular difficult to interpret. Use of the facial nerve instead is recommended. ...

We dont have very precise tools to evaluate the way the nervous system functions. We have electrophysiological studies like EMG and nerve conduction velocity assessments, but theyre often negative in people who have widespread or other localized pain complaints, and people have been told that that means that theres nothing wrong with them. But whats been underappreciated is that an EMG or nerve conduction velocity test only measures the largest nerve fibers and not the small fibers. Small fibers, meaning weakly or unmyelinated nerve fibers, are the ones that control pain or transmit pain information. The large nerve fibers dont. So for years, weve been addressing painful disorders with a tool that doesnt measure the nerve fiber types that are involved in pain processing.. Its been demonstrated in a wide variety of chronic painful conditions, that the major pathological state is the reduction of nerve fiber density in the skin of individuals who have chronic widespread complaints. Weve ...

This chapter talks about a 54-year-old right-handed man who was brought to medical attention by his daughter because of progressive speech difficulty over the last 2 years. The patient was clinically diagnosed with fronto-temporal dementia with non-fluent progressive aphasia as well as behavioral symptoms. Sensory and motor nerve conduction studies were normal. EMG needle electromyography showed mixed denervation pattern in the right FDI and left biceps with 2_ fasciculation potentials, positive sharp waves, and fibrillations. Motor units were polyphasic with increase in sharp waves. External examination of the formalin-fixed brain showed no obvious cerebral atrophy or no focal lesions. The base of the brain was unremarkable apart from mild patchy atherosclerosis. Serial coronal sections through the cerebral hemispheres showed a normal ventricular system and deep gray structures. Sections of the brainstem and cerebellum were also unremarkable apart from mild loss of pigmentation of substantia ...

Nerve conduction in unmyelinated fibers has long been described based on the equivalent circuit model and cable theory. However, without the change in ionic concentration gradient across the membrane, there would be no generation or propagation of the action potential. Based on this concept, we employ a new conductive model focusing on the distribution of voltage-gated sodium ion channels and Coulomb force between electrolytes. Based on this new model, the propagation of the nerve conduction was suggested to take place far before the generation of action potential at each channel. We theoretically showed that propagation of action potential, which is enabled by the increasing Coulomb force produced by inflowing sodium ions, from one sodium ion channel to the next sodium channel would be inversely proportionate to the density of sodium channels on the axon membrane. Because the longitudinal number of sodium ion channel would be proportionate to the square root of channel density, the conduction velocity

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Retrospective study of prospectively collected data to assess the reliability of cervical magnetic stimulation (CMS) to detect prolonged phrenic nerve (PN)

Diabetic foot occurs in 15% of diabetic population (3) and 15% of the diabetic foot patients end up with lower limb amputation. Peripheral neuropathy (sensory, motor and autonomic), peripheral vascular disease, trauma, infection and poor wound healing all contribute to diabetic foot problem.. Peripheral neuropathy could be evaluated in a variety of ways, including vibratory thresholds, thermal thresholds, pressure perception thresholds, muscle strength. All these predict foot ulceration to some degree(1). Motor nerve conduction velocity is an independent predictor for the development of new foot ulcer in diabetic population.. For more detailed structural study of neuropathy in diabetic patient, we could use skin biopsy method. Skin biopsy with PGP9.5 immunohistochemistry has been demonstrated by ultrastructural studies to label the terminal portions of both small myelinated and unmyelinated nerve in the epidermis . Intra-epidermal nerve fiber (IENF) density is reduced in patient with impaired ...

Assessment of central and peripheral motor pathways. Magnetic stimulation has proved effective in the assessment of central and peripheral motor pathways. The alternating magnetic field generated by the stimulator easily passes through clothes, skin, scalp, bones, and meninges. Reaching the conductive tissues of central and peripheral nervous systems, this field creates an alternating electric field which in turn induces an electric current that can activate the neurons as during electrical stimulation. However, if compared to electrical stimulation, magnetic stimulation does not cause painful sensations that usually occur due to the activation of skin receptors under the electrode and does not require additional preparation time. Using an EMG system during stimulation allows recording motor evoked potentials (MEPs) from the muscles innervated by those neurons. This principle underlies a variety of diagnostic tests such as central motor conduction time, cortical silent period, and ...

We have analysed the influence of complex drug cocarnit (20 mg nicotinamide, 50 mg cocarboxylase, 0.5 mg cyanocobalamin, 10 mg disodium adenosine trip..

Electrophysiological Studies in the Gdain-Barr6 Syndrome J. G. McLeod, MB BS, D Phil ~ Electrophysiological studies were performed on 114 patients with Guillain-Barre syndrome and t h e literature was reviewed. Abnormalities of motor and sensory conduction were present in about 90% of the patients. Because of the patchy distribution of demyelinating lesions, the likelihood of detecting electrophysiological abnormalities increases with the number of nerves studied. Marked slowing of conduction or an abnormally prolonged distal motor latency consistent with demyelination was found i n one or more nerves in about 50% of the patients. Abnormalities of conduction not present in t h e early stages of t h e illness may become evident at t h e peak of disability or during the recovery phase. T h e application of F-wave studies and somatosensory evoked potential recordings may assist in detecting demyelinatiori in roots and proximal segments of the peripheral nervous system. T h e r e is no correlation ...

BACKGROUND AND PURPOSE: High-resolution ultrasound is a valuable tool in supporting the diagnosis of multifocal motor neuropathy (MMN) but longitudinal data under therapy are lacking. METHODS: The change in peripheral nerve ultrasound pattern in patients with MMN was assessed over time. Patients with MMN received a thorough initial examination and follow-up over a period of 6-12 months using high-resolution ultrasound of the cervical roots and the nerves of the arms and legs, nerve conduction studies, Medical Research Council Sum Score (MRCSS) and Rotterdam Inflammatory Neuropathy Cause and Treatment Group (INCAT) score to evaluate changes under treatment ...

Action potential conduction in myelinated nerve fibers depends on a polarized axonal membrane. Voltage-gated Na(+) and K(+) channels are clustered at nodes of Ranvier and mediate the transmembrane currents necessary for rapid saltatory conduction. Paranodal junctions flank nodes and function as atta …

A nerve conduction study (NCS) is a measurement of the speed of conduction of an electrical impulse through a nerve. NCS can determine nerve damage such as due to compression or disease (e.g. diabetes) During the test, the nerve is stimulated, usually with surface electrode patches attached to the skin. Two electrodes are placed on the skin over the nerve. One electrode stimulates the nerve with a very mild electrical impulse and the other electrode records it. The resulting electrical activity is recorded by another electrode. This is repeated for each nerve being tested. The nerve conduction velocity (speed) is then calculated by measuring the distance between electrodes and the time it takes for electrical impulses to travel between electrodes ...

Your veterinarian will perform a thorough physical exam on your cat, taking into account the background history of symptoms and your cats genetic background. Standard tests include a blood profile, including a chemical blood profile, a complete blood count, and a urinalysis.. Diagnosis is based on the clinical signs that your cat is presenting, but for a conclusive diagnosis, your veterinarian will take a sample/biopsy of the nerve to analyze for sufficient myelin at the axon of the nerve. Your doctor may also choose to perform a brain biopsy. Other techniques include electromyography, which measures the electrical activity and potential of the muscle cells. In this case, the finding is usually normal to mild spontaneous activity. Motor nerve conduction velocity can be used to assess the ability of the motor and sensory nerves to conduct electricity. With hypomyelination, there is usually slowed conduction or only a small amount of potential.. ...

Electrical conduction is very rapid and highly anisotropic in atrial fiber bundles, such as the crista terminalis. In contrast to left ventricular myocardium in which the ratio of longitudinal to transverse conduction velocities is approximately 3, propagation velocity in the crista terminalis is approximately 10 times greater in the longitudinal than in the transverse direction. To elucidate potential determinants of these distinct conduction properties, we characterized structural and molecular features of intercellular coupling in the crista terminalis and left ventricular myocardium of the canine heart. Analysis of the number and spatial orientation of myocyte interconnections at gap junctions revealed that a typical left ventricular myocyte was connected to 11.3 +/- 2.2 other myocytes. Approximately equal numbers of connections occurred between ventricular myocytes juxtaposed in side-to-side and end-to-end orientation. In contrast, a typical myocyte of the crista terminalis was connected to ...

The skin over the areas being tested is cleaned. A needle electrode is put into a muscle. The electrode is attached by wires to a recording machine.. When the electrodes are in place, the electrical activity in that muscle is recorded while the muscle is at rest. Then the technologist or doctor asks you to tighten (contract) the muscle slowly and steadily. This electrical activity is recorded.. The electrode may be moved a number of times. This is done to record the activity in different parts of the muscle or in different muscles.. The electrical activity in the muscle is shown as wavy and spiky lines on a video screen. It may also be heard on a speaker. You may hear popping sounds like a machine gun when you contract the muscle. The activity may also be recorded on video.. An EMG may take 30 to 60 minutes. When the test is done, the electrodes are removed. The places where a needle was put in the skin are cleaned.. ...

Neurology services, specifically EMG and Nerve Conduction Studies, are offered at the Center by Dr. Reynaldo Lazaro. Electromyography (EMG) and Nerve Conduction Studies (NCS) are special electronic tests used to evaluate the function of muscles and nerves. NCS are performed by applying electrodes over a nerve or muscle, usually in the hand or foot, and then stimulating a nerve (delivering tiny shocks) in different locations along its course. EMGs are performed by inserting small needle electrodes into various muscles to assess their function. By using NCS and EMGs a more specific neuromuscular diagnosis can often be made, which can be helpful in directing therapy and establishing prognosis.. NCS and EMGs are useful in evaluating:. ...

Overview Well start by discussing some general guidelines, types of services in the medicine section, and different types of neurology and neuromuscular services common on workers comp bills... Hi! In this module, you will learn about different types of services in the medicine section of the OMFS. Medicine Guidelines Neurology and Neuromuscular Services Electromyography (EMG) Nerve Conduction Studies (NCS) Medicine Guidelines Neurology and Neuromuscular Services Electromyography (EMG) Nerve Conduction Studies (NCS) Psychiatry Ophthalmology

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TY - JOUR. T1 - Pathophysiology and treatment of painful diabetic neuropathy of the lower extremity. AU - Wunderlich, R P. AU - Peters, E J. AU - Bosma, J. AU - Armstrong, D G. PY - 1998/10. Y1 - 1998/10. N2 - BACKGROUND: Symptomatic peripheral neuropathy is the most common complication of diabetes mellitus, affecting up to 62% of Americans with diabetes.METHODS: We reviewed the literature using the National Library of Medicines MEDLINE search service. In total, we reviewed 54 articles.RESULTS: Hyperglycemia leads to increased activity in the polyol pathway in nerve cells; this ultimately results in abnormal nerve function. Numerous pharmacologic agents have been used to treat symptomatic peripheral neuropathy, but all of these drugs can be associated with adverse side effects. Recent work has indicated that subsensory electrical stimulation may be preferred to pharmacotherapy, since it is equally effective and has a more favorable safety profile.CONCLUSION: Although the pathophysiology of ...

A method and system for ascertaining the condition of the hearts conduction system in a patient treated for congestive heart failure with pacing therapy. In accordance with the invention, changes in ventricular activation patterns are monitored over time in order to detect changes in the hearts conduction system that may occur due to physiological regeneration of conduction pathways. The activation patterns are reflected by electrogram signals detected from different ventricular locations. By measuring the difference in conduction times of an excitation impulse traveling from the AV node to the different ventricular locations, a parameter representative of the hearts conduction system is obtained that may be used to adjust the pacing therapy in accordance therewith.

The peripheral nerve disorders associated with diabetes are complex and probably involve a variety of causative mechanisms. This may give rise to difficulty in the classification of individual cases. A broad separation into rapidly reversible or more persistent phenomena is helpful. The former, which can be categorized as hyperglycemic neuropathy, include minor sensory symptoms, reduced nerve conduction velocity, and resistance to ischemic conduction failure. From analogy with experimental studies in animals, nerve hypoxia is likely to play a significant role in their origin. Of the more persistent phenomena, a distal symmetric polyneuropathy that predominantly affects sensory and autonomic function is the most common manifestation. A distal axonopathy of dying-back type may represent the underlying pathogenetic basis. Other more persistent phenomena consist of focal and multifocal lesions giving rise to cranial, thoraco-abdominal, and limb neuropathies, including proximal lower limb motor ...

AIAES : Neuropathy patients have variable sensory disturbance (loss or exaggerated sensation) with pain, weakness, and autonomic involvements such as sweat abnormalities, gastrointestinal dysfunction, and lightheadedness on standing. These symptoms are as a result of injury to the distal nerves, roots, ganglia or their gathering points (nerve plexus in the thighs and arms). Patients may have symmetric or asymmetric involvements of the extremities, trunk, and head including extraocular muscles. Subacute onsets and asymmetric involvements favor inflammatory or immune causes over inherited or metabolic forms. Depending on the specific inflammatory or immune mediated causes other parts of the nervous system may also be affected (brain, cerebellum, spinal cord).   In the evaluation of patients with immune mediated autoantibody neuropathies, nerve conduction studies and needle electromyography can help to classify the neuropathy as either: 1) primary axonal; 2) primary demyelinating; or 3) mixed axonal

A neurographic examination of 54 patients with essential hypertonia did not reveal any significant differences, from a control group, in the maximum rate of motor conduction of the ulnar nerve. An assocation of subclinical neuropathy with essential hypertonia cannot, therefore, be confirmed, thus denying the statement made by Viskoper and his coworkers and saying that the motor nerve conduction speed was an objective index for determining the severity of diseases characterized by hypertension.

Objectives: To compare the results of nerve excitability test (NET) with the Iateneyand amplitude of the compound muscle action potential (CMAP) and to determine the prognostic value of quantitative measurement of muscle power in the prognosis of Bells palsy. Patients and Methods: Sixty-two patients with newonset Bells palsy were evaluated with NET, CMAP Iateney and amplitude and the quantitative measurement of muscle power. The palsies were classified according to the House-Brackmann system. The results were obtained from both the involved and healthy sides and compared with those obtained six months Iater. Results: According to the House-Brackmann system, improvement was complete in 38 patients, good (grade II-III) in 10 patients, moderate (grade IV-V) in eight patients, and poor (grade VI) in six patients. Improvement was significantly correlated with the initial values of NET and CMAP amplitudes (NET: r=-80, ...

Many technologies require the understanding of conduction and electrical transport mechanisms through nanostructures. Previous research has revealed unusual and enhanced conduction properties in pores whose width is significantly less than 1 m over a range of +10V to -10V. Characterization of the enhanced conduction will include experimental measurements and theoretical models looking to explain the effects of nanopore size, bulk ionic concentration, solute ionic charge, solvent, semiconductor versus metallic contacts and voltage upon conduction current. The model will attempt to adapt the concepts of the ionic atmosphere, dielectric effects at interfaces, ionic density and mobility to the unique environment within the nanopore. By exploiting the enhanced current, there exists the potential for order-of-magnitude improvements in sensors, computation and communications. Conduction and attachment mechanisms are the cornerstone to the successful integration of nano-devices into Naval systems using

The Physicians of RPG can provide Electrodiagnostic Testing (EMG) and Nerve Conduction Studies (NCS) for your patients who complain of specific or non-specific numbness/tingling related to diabetic peripheral neuropathy or to provide reassurance of no nerve involvement.. ...

The 2012 version of CPT includes 3 add-on codes and introductory language for needle electromyography (EMG) performed in conjunction with nerve conduction studies. This document includes a description of the new codes and guidance for their use. The codes are available for physical therapists (PTs) to report effective January 1, 2012. However, PTs should check payer policy to determine coverage of the codes. ...