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Activity-guided fractionation of a hop extract led to the isolation of XN and of its cyclization product, the flavanone IX, as potential cancer chemopreventive agents. Although hop constituents have been previously reported to modulate carcinogen metabolism and to act by cytotoxic/cytostatic mechanisms, a demonstration of chemopreventive activity in animal models and of potential value for chemoprevention in humans is missing.. In vivo efficacy of selected chalcones as chemopreventive agents against pulmonary and oral carcinogenesis has been demonstrated in a limited number of studies (49, 50). Interestingly, the chalcone structure of XN is modified by substitution with a prenyl side chain. Prenylation is an important posttranslational modification of proteins, e.g., the Ras oncoprotein, and results in higher lipophilicity and targeting of the modified protein to the cell membrane (51). It is tempting to speculate that likewise, prenylation might also influence solubility, cellular uptake, and ...
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adidas Originals levels up its highly sought-after Tubular sneaker styles with a mighty uplift in this Doom edition, designed with maximum functionality. Bouncing off a featherlight sole in embossed rubber, this neoprene pair provides height, lift and traction all in one without compromising on comfort. Fitted with an engineered knit sock for snug warmth, these also endure nighttime use with its reflective lizard-effect quarter and heel panels.. ...