The analytical performance of the CellSearch system for the isolation and enumeration of CTCs in 7.5 mL of blood was evaluated. Recovery of cells of the SKBR-3 tumor cell line spiked into 7.5 mL of blood using the CellSearch system was greater than 85% and linear over the range of CTCs routinely detected in the majority of metastatic carcinoma patients. The reproducibility of the assay measured at two cell spike levels provided a total CV of 9.4% at 319 cells and 15.8% at 58 cells.. The heterogeneity of EpCAM expression on the surface of CTCs can cause variation in the ability to recover and/or detect these cells both in cell lines and in patient samples. Variation in the selection efficiency caused by varying EpCAM antigen density on CTCs was reduced by using a method that increases the magnetic load of cells expressing low antigen densities (32) . Even with these improvements in the assay, the analytical performance achieved with the CellSearch system using blood samples spiked with tumor ...

Zion Market Research analysts forecasts the latest report on Global Liquid Biopsy Market Is Set Expected To Reach Around USD 12,062 Million By 2025 , according to their latest report. The following report contains an interpretation of the marketing plan for Liquid Biopsy Market. Global Liquid Biopsy Market Report concentrates on the strong analysis of the present state of Liquid Biopsy Market which will help the readers to develop innovative strategies that will act as a catalyst for the overall growth of their industry. (Sample Copy Here) This research report segments the Liquid Biopsy Market according to Type, Application and regions. It highlights the information about the industries and market, technologies, and abilities over the trends and the developments of the industries.. The Liquid Biopsy Market report also includes the bifurcation of the Liquid Biopsy Market based on the kind of service or product, technology, end-users, applications, and others. Further, it entails extensive data ...

Background Although CTC detection has been studied in patients receiving preoperative chemotherapy, fewer data exist for preoperative chemotherapy combined with anti-HER2 agents. Here, we report a sub-study of CTC detection within the NeoALTTO trial.. Methods NeoALTTO is a randomized phase III trial in which patients with primary HER2+ breast cancer were randomized to trastuzumab, lapatinib or their combination for 6 weeks followed by the addition of paclitaxel for 12 weeks prior to surgery. Participation in the CTC sub-study was optional. Blood samples were prospectively collected at baseline, after 2 weeks of anti-HER2 treatment alone and prior to surgery. A total of 22.5mL of blood was reduced to 7.5mL using a modified ficoll procedure that was then processed using CellSearch®. Evaluation of HER2 expression in CTCs was performed using the CellSearch® HER2 profiling kit. CTCs with HER2 staining intensity of 2 + /3+ were considered as HER2+. Associations between CTC detection and primary ...

The identification of circulating tumor cells (CTCs) may provide important prognostic information in several types of solid tumors, including gastric cancer. The aim of this study was to investigate whether CTC count may be used to predict survival in patients with advanced gastric cancer treated with chemotherapy. The CELLection™ Epithelial Enrich kit was used to isolate and purify CTCs from samples of peripheral blood. immunofluorescent staining was used for CTC counting. High CTC counts were associated with poor tumor differentiation and high serum CEA levels (P=0.021 and 0.005, respectively). After 3 months, 16 patients with decreasing CTC counts after the first cycle of chemotherapy obtained complete response, partial response or stable disease, while 13 patients with increasing CTC counts developed progressive disease. The patients with decreasing CTC counts also exhibited longer progression‑free survival (PFS) (P≤0.001) and overall survival (OS) (P=0.002) compared with those with ...

Background: High circulating tumor cell (CTC) counts are associated with poor prognosis in several cancers. Enrolment of patients on Phase 1 oncology trials requires a careful assessment of the potential risks and benefits. Many patients enrolled on such trials using established eligibility criteria have a short life expectancy and are less likely to benefit from trial participation. We hypothesised that the incorporation of CTC counts might improve patient selection for phase I trials. Methods: This retrospective analysis evaluated patients who had baseline CTCs enumerated prior to their starting on a Phase 1 trial. CTCs were enumerated using the CellSearch System. Results: Between January 2006 and December 2009 a total 128 patients enrolled in Phase 1 trials had CTC counts evaluated. Higher CTC counts as a continuous variable independently correlated with risk of death in this patient population (p=0.006). A multivariate point-based risk model was generated using CTCs as a dichotomous variable ...

This test can detect the presence of cirulating tumor cells (CTC) in the peripheral blood of patients with metastatic breast cancer, colorectal or prostate cancer in patients. A count of 5 CTC or more in breast and prostate cancers and 3 CTC or more in colon cancer in 7.5 mL of blood is predictive of shorter progression free survival and overall survival. Physicians can draw samples prior to a new line of therapy for baseline prediction. Physicians can also draw samples at the first follow-up visit for evaluating response to therapy. The Veridex CellSearch System is the only semi-automated system designed to standardize and optimize the measurement of CTC in peripheral blood, this test is also the only FDA approved kit for CTC detection ...

TY - JOUR. T1 - Liquid biopsy in germ cell tumors. T2 - biology and clinical management. AU - Chovanec, Michal. AU - Kalavska, Katarina. AU - Mego, Michal. AU - Cheng, Liang. PY - 2020/2/1. Y1 - 2020/2/1. N2 - Introduction: Liquid biopsy is an increasingly studied approach for optimal and minimally invasive diagnostics of malignant tumors. The aim of this review is to provide evidence and discuss the utility of liquid biopsy in the management of germ cell tumors (GCTs). Areas covered: Herein, we summarize the evidence on liquid biopsy in GCTs including serum tumor markers, circulating tumor cells, microRNA and cell-free DNA. The search of literature was conducted from Pubmed/Medline, ASCO-meeting library searching for terms liquid biopsy, germ cell tumors, circulating tumor cells, microRNA, cell-free DNA. Obtained original studies were included. Reference lists of review articles and key original articles were searched for additional original studies. We included articles published ...

TY - JOUR. T1 - Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid-induced 2. AU - Werner, Stefan. AU - Brors, Benedikt. AU - Eick, Julia. AU - Marques, Elsa. AU - Pogenberg, Vivian. AU - Parret, Annabel. AU - Kemming, Dirk. AU - Wood, Antony W.. AU - Edgren, Henrik. AU - Neubauer, Hans. AU - Streichert, Thomas. AU - Riethdorf, Sabine. AU - Bedi, Upasana. AU - Baccelli, Irene. AU - Jucker, Manfred. AU - Eils, Roland. AU - Fehm, Tanja. AU - Trumpp, Andreas. AU - Johnsen, Steven. AU - Klefstrom, Juha. AU - Wilmanns, Matthias. AU - Muller, Volkmar. AU - Pantel, Klaus. AU - Wikman, Harriet. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Regulatory pathways that drive early hematogenous dissemination of tumor cells are insufficiently defined. Here, we used the presence of disseminated tumor cells (DTC) in the bone marrow to define patients with early disseminated breast cancer and identified low retinoic acid-induced 2 (RAI2) expression to be ...

Researchers are exploring how broadly liquid biopsies might be used. In the Journal of Clinical Oncology: Precision Oncology, a Mayo Clinic research team reported the array of cancer-related genetic mutations present in liquid biopsies of bile duct cancer, a form of liver cancer also known as cholangiocarcinoma. We charted the landscape of genetic alterations present in circulating tumor DNA among patients with cholangiocarcinoma, explains Dr. Mody, the articles lead author. The team evaluated liquid biopsies in one of the largest patient cohorts to date: 124 patients with cholangiocarcinoma who were treated across Mayos three campuses. Our findings provide a foundation for further development of liquid biopsies as a way to advance precision medicine for patients with cholangiocarcinoma, he says.. Cholangiocarcinoma is uncommon in the U.S., where about 5,000 new cases are diagnosed each year, though numbers have been on the rise in recent decades. The cancer is more prevalent in Southeast ...

Summary In clinical practice imaging technologies such as computed tomography (CT), positron emission tomography (PET)/CT and magnetic resonance imaging (MRI) are well-established methods for monitoring metastatic breast cancer (MBC) patients and for assessing therapeutic efficacy. However, several weeks of treatment are required before these technologies can offer any reliable information on effective disease regression, and, in the meanwhile, the patients are exposed to potentially unnecessary therapy. Circulating tumor cells (CTCs) have been shown to be powerful prognostic and predictive markers and provide clinicians with valuable information. However, in one clinical trial, an early change of chemotherapy based on CTC detection did not result in improved survival. Currently, CTC detection outside clinical trials should be limited to selected clinical situations, i.e. increased treatment toxicity or as risk estimation.. © 2014 S. Karger GmbH, Freiburg. ...

TY - JOUR. T1 - 18 F-FDG PET/CT findings and circulating tumor cell counts in the monitoring of systemic therapies for bone metastases from breast cancer AU - De Giorgi, Ugo. AU - Mego, Michal. AU - Rohren, Eric M.. AU - Liu, Ping. AU - Handy, Beverly C.. AU - Reuben, James M.. AU - Macapinlac, Homer A.. AU - Hortobagyi, Gabriel N.. AU - Cristofanilli, Massimo. AU - Ueno, Naoto T.. PY - 2010/8/1. Y1 - 2010/8/1. N2 - Our objective was to compare the predictive significance of 18 F-FDG PET/CT findings and circulating tumor cell (CTC) count in patients with bone metastases from breast cancer treated with standard systemic therapy. Methods: Breast cancer patients with progressive bone-only metastatic disease without visceral metastases starting a new line of systemic therapy underwent 18 F-FDG PET/CT and had CTC counts determined before and during treatment. Disease status was reassessed by CTC count (≥5 vs. ,5 CTC/7.5 mL of blood) and 18 F-FDG PET/CT approximately 2-4 mo after initiation of the ...

Liquid biopsy group is focused on studying the tumour material in biological fluids, mainly blood from breast and prostate cancer patients. There are different tumour materials that can be analysed: circulating tumour cells (CTCs) which cause metastasis, tumoural genetic material ctDNA/ctRNA, extracellular vesicles and other blood components such as platelets. Our main goal is isolated and molecular characterized both CTCs and tumoral genetic material in the circulatory system to identify prognostic biomarkers of response, resistance and possible therapeutic targets.. Ongoing projects:. - Liquid biopsy for precision oncology.. - Identification of resistance mechanisms to systemic treatment in Luminal advanced breast cancer. - New approaches in Liquid Biopsy: study of blood biomarkers with diagnostic utility in breast cancer and its function in the metastatic cascade.. ...

Tumor cell dissemination in bone marrow or other organs is thought to represent an important step in the metastatic procedure. agents also to progress our knowledge of the biology of metastasis. Intro Breast cancers (BC) may be the most common tumor in ladies in European countries [1]. Despite medical procedures and adjuvant systemic therapy a lot of women with early BC still relapse and perish of their disease. Minimal residual disease (MRD) after possibly curative medical procedures for BC can be thought to donate to disease relapse also to be the prospective of adjuvant treatment. MRD is thought as micrometastatic cells undetectable by conventional lab and imaging testing. Surrogates of MRD are tumor cells recognized in the bone tissue marrow (disseminated tumor cells (DTCs)) and peripheral bloodstream (circulating tumor cells (CTCs)) [2]. The recognition and characterization of DTCs/CTCs are anticipated to result in customized treatment strategies and speed up the introduction of novel ...

The presence of circulating tumor cells (CTC) in the blood of patients with metastatic breast cancer (MBC) is an independent prognostic and predictive factor (1-9). Several techniques have been used to isolate, enumerate, and characterize CTCs, all of which rely on procedures to enrich for epithelial cells that express the epithelial cell adhesion molecule, EpCAM/CD326. The U.S. Food and Drug Administration-cleared CellSearch system defines CTCs as EpCAM/CD326+ nucleated cells that co-express cytoplasmic cytokeratins (CK8, CK18, and CK19) and not the common leukocyte antigen, CD45 (1). Recently, we found that CTCs detected by CellSearch are heterogeneous, with different prognostic values among breast cancer subtypes (10). In particular, CTCs lack predictive value in patients with HER2-amplified (HER2+) tumors treated with targeted therapy (11, 12). One possible explanation for this observation is the loss of the expressions of EpCAM (13) on CTCs that may be undergoing epithelial-mesenchymal ...

Liquid biopsies are currently conducted primarily for research, to help scientists better understand the basic biology of cancer. Last year, for example, researche led by Dana-Farbers Geoffrey Oxnard, MD, and Cloud Paweletz, PhD, reported the discovery of a new type of drug-resistant mutation that occurs in lung cancer patients after treatment with a new targeted therapy called osimertinib. This mutation, known as EGFR C797S, was first identified in tumor DNA floating in a patients blood and was later confirmed by a tumor biopsy.. One of the challenges of liquid biopsies has been ensuring adequate accuracy. In some cases, there is very little tumor DNA present in the blood specimen, making it difficult to detect cancer-related mutations. Currently, conventional tissue biopsies remain the gold standard for determining the genetic makeup of tumors in patients.. As liquid biopsy techniques have been refined and improved in recent years, theyve begun to approach the accuracy and reliability of ...

A liquid biopsy is an emerging tool for the diagnosis of cancer disease nowadays. The liquid biopsy involves collecting samples and analysing tumours in the blood to diagnose cancer disease in the human body. Liquid biopsy assists medical practitioners as a source of genomic and proteomic knowledge in cancer patients by early detection of circulating...

Global Liquid Biopsy Market: Overview A liquid biopsy is testing of a sample of blood of tumor circulating within blood or pieces of DNA of the tumor to detect cancer cells. A liquid biopsy is done at an early stage to detect cancer; it is the most prominent test which is used to detect cancer.…

Novel liquid biopsy technology combines machine learning and low-cost cell free DNA genome-wide fragmentation profiles. BALTIMORE, January 12, 2021 /PRNewsire/ - Delfi Diagnostics, Inc., a pioneering developer of a new class of high performance, affordable liquid biopsy tests for early cancer detection, has raised $100 million in Series A funding. The round was led by OrbiMed, with participation from existing investors including Menlo Ventures, Samsara Biocapital, Illumina Ventures, AV8 Ventures, and Windham Venture Partners, and new investors including Foresite Capital, Northpond Ventures, Cowen Healthcare Investments, Rock Springs Capital, Osage University Partners, and funds and accounts advised by T. Rowe Price Associates, Inc. Delfi plans to use this round of funds to expand its team of cancer researchers and machine learning experts and to validate its novel next-generation liquid biopsy technology through multiple prospective clinical studies.. Delfis technology leverages advances in ...

Summary: New legislation HR 8845 would provide Medicare coverage when the FDA approves multi-cancer liquid biopsy screening tests. The bill would bypass a current bottleneck requiring USPTF review prior to CMS consideration.. ____________. Its been a busy several months for liquid biopsy cancer screening, with multiple funding rounds announced (probably capped by a proposed acquisition of GRAIL for $8B), a proposed NCD for liquid biopsy colorectal cancer screening, an NHS study in the UK announced, and now some major legislation.. The legislation is HR 8845 with the full bill text here. It would update Social Security Act Section 1861 with a new benefit category, for FDA-approved multi cancer screening tests. Currently, such tests could only be adopted as Medicare benefits if endorsed by the USPSTF, a process that could take 3-5 years after FDA approval. Ive argued that USPSTF review has largely proved redundant to CMS review (both agencies write the same 40-page report on the same data). The ...

We are working hard with all share holders to creat greater access to Liquid Biopsy Clinics Near You, providing access is key and our goal is to help every rural area and community as well as the big cities provide assess. We are hayyp to connect you with a local Liquid Biopsy Center and notify you as new ones open in your area.. ...

Most companies exploring liquid biopsies use technologies that search for and sequence DNA strands shed by tumours into a patients blood. Not so Menarini Silicon Biosystems: the company offers Cellsearch, the only FDA-cleared product for the enumeration of entire circulating tumour cells (CTCs) in blood samples.. With CTCs we can offer a wide range of information compared to circulating tumour DNA [ctDNA], Fabio Piazzalunga, president of MSB, tells Vantage. We believe that the future will be linked to single-cell technologies. Single cell analysis is a technique that can aid the understanding of metastasis and therapy resistance with more precision than bulk tumour measurements, as well as tease out the role of rare cells in tumour progression. MSBs Cellsearch technology can perform this testing; the company, a subsidiary of the private Italian pharma company Menarini, bought Cellsearch from Janssen in 2017.. Cellsearch can obtain clinically useful information in a number of ways. Most ...

View Full Size Image Circulating tumor cells (CTCs) are cancer cells that break away from either a primary tumor or metastatic site, and circulate in the peripheral blood as the cellular origin of metastasis. With their role as tumor liquid biopsy, CTCs provide convenient access to all disease sites, including that of the primary tumor and the site of fatal metastases. It is conceivable that detecting and analyzing CTCs will provide insightful information in assessing the disease status without the flaws and limitations encountered in performing conventional tumor biopsies. However, identifying CTCs in patient blood samples is technically challenging due to the extremely low abundance of CTCs among a large number of hematologic cells. To address this unmet need, there have been significant research endeavors devoted to developing CTC detection, isolation, and characterization technologies. Inspired by the nanoscale interactions observed in the tissue microenvironment, our research team at UCLA ...

Introduction Recurrent/metastatic (R/M) HNSCC have a poor prognosis. Palliative chemotherapy is often used without adequate prognostic and predictive stratification due to the lack of validated predictors in this setting. Furthermore, anti-EGFR therapy is used under the assumption that more than 80% of the primary tumors overexpresses EGFR. CTCs have been identified as prognostic and predictive indicators in several metastatic cancers. We prospectively studied the frequency, clinical significance and EGFR expression of CTCs in pts with R/M HNSCC.. Patients and methods Pts with local and/or distant relapse of HNSCC at first or second relapse were included between January 2009 and December 2011. CTCs were measured at baseline and at end of treatment or progression. CTCs analysis was performed with the CellSearch® system. The diagnostic performance of the system with squamous cancer cells was tested with cell lines spiking experiments. The CellSearch® fourth channel was used to analyze EGFR ...

Excerpt:. Three manuscripts published in the recent issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), explored the versatility of liquid biopsies by identifying EGFR mutations using circulating tumor DNA (ctDNA) in urine and plasma and examining circulating tumor cells (CTCs) in plasma to predict the risk of lung cancer recurrence after surgical resection. Collectively, these findings illustrate the potential and reach of liquid biopsies in both identifying patients suitable for targeted treatment as well as predicting cancer recurrence.. Lung cancer is the most common type of cancer with the highest cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) accounts for roughly 85% of lung cancer and most patients present with advanced disease at diagnosis. Surgical resection is the preferred treatment option for patients with medically operable tumors. However, disease recurrence occurs in ...

Epithelial-mesenchymal transition (EMT) is implicated in the metastatic process and presents a challenge to epithelial cell adhesion molecule-based detection of circulating tumor cells (CTCs), which have been demonstrated to be a prognostic indicator in metastatic breast cancer. Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression, no standard recommendations have been established for clinical practice. This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients. We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes (including epithelial CTCs, biphenotypic epithelial/mesenchymal CTCs, and mesenchymal CTCs) in peripheral blood samples. Receiver operating characteristic curve analyses of total CTC

Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal transition (EMT) of individual tumour cells. During EMT, adhesion molecules like E-cadherin are downregulated and the decrease of cell-cell adhesion allows tumour cells to dissociate from the primary tumour mass. This complex process depends on intracellular cues that are subject to genetic and epigenetic variability, as well as extrinsic cues from the local environment resulting in a spatial heterogeneity in the adhesive phenotype of individual tumour cells. Here, we use a novel mathematical model to study how adhesion heterogeneity, influenced by intrinsic and extrinsic factors, affects the dissemination of tumour cells from an epithelial cell population. The model is a multiscale cellular automaton that couples intracellular adhesion receptor regulation with cell-cell adhesion. Simulations of our mathematical model indicate profound effects of adhesion heterogeneity on tumour cell dissemination. In

Sequencing genetic material from liquid biopsies promises to be one of the most important recent developments in cancer diagnostics. The relative ease and minimally invasive nature of obtaining liquid biopsies makes it an attractive alternative source of tumor DNA relative to direct tumor biopsies. The importance that

The aim of this study is to evaluate the performance of Inivata liquid biopsy analysis compared with standard tissue biopsy analysis for detection of genomic alterations in patients with advanced lung cancer. Once selected for the study and with full informed consent, patients will have a blood draw to allow the detection of cancer-related genomic alterations that are detectable within the blood sample. These results will be compared to results obtained from genomic profiling via standard tissue biopsy taken as part of routine care to help determine whether such liquid biopsies can be used to guide treatments in future patients. The results of the liquid biopsy will not be used to guide treatment decisions in study participants.. In addition there is data-collection of treatments received for non small cell lung cancer and the response to these treatments during the first 6 months post tissue and blood analysis, though no additional visits or procedures are required for the patient beyond the ...

Using a simple blood sample, free-floating nucleic acids or nucleic acids from circulating cells and exosomes can reveal valuable insights into genomic drivers of cancer development or chromosome aneuploidies in fetal development research. This genomic analysis of peripheral blood, known as a liquid biopsy, presents a low-cost, low-risk way to access valuable genomic information without invasive surgical procedures. QIAseq NGS products enable you to uncover the full discovery potential from any liquid biopsy sample. ...

As a growing body of evidence demonstrates intertumoral and intratumoral heterogeneity and clonal evolution, both during carcinogenesis and also throughout treatment resulting in acquired drug resistance, the utility of blood-based assays or liquid biopsies is becoming increasingly recognized in clinical practice and trial design. Liquid biopsies provide a less invasive approach to the current gold standard of interrogating tumors by tissue biopsies, which are frequently unfeasible, associated with morbidity, and cannot be performed as often ...

Liquid biopsy is a non-invasive and simple alternative of conventional surgical biopsies that enable medical professionals to detect cancer causing tumours just by taking the blood sample of the patient. In this manner, liquid biopsy assists the doctors in selecting the correct treatment procedure for patients at right time.

A $45 million funding round completed by DiaCarta to help develop a liquid biopsy test for colorectal cancer is just the latest proof that venture capitalists continue to see liquid biopsy companies as an attractive investment.

From this September, barnaclínic+ Medical Oncology is providing its patients with the best liquid biopsy test currently available for advanced cancer, Guardant-360. Thanks to the agreement between the Medical Oncology and Pathology departments of the Hospital Clínic de Barcelona and the company Guardant Health, the Clínic will be the first centre in Europe to routinely use one of the most advanced liquid biopsy tests on the market.. Leer más… ...

DataLibraryResearch.com add report title Liquid Biopsy Market Opportunities and Forecast 2020-2027 with table of content and report contain 120 pages.. Overview. The report produces a brief introduction to the basic profile of the whole industry. Key factors influencing growth like pricing, sales volume, market trends, and others are included in the report. The researchers have considered the year 2020 as the base year against which all data has been analysed. The forecast period under consideration for the report is 2020-2027. The intricacies involved in getting the product/service to remain profitable and to maintain sustainability in the fluctuating market environment have been reported.. Request a Free Sample Copy at https://www.datalibraryresearch.com/sample-request/liquid-biopsy-market-2125. Segmentation. The Liquid Biopsy industry can be segmented on type, by application, and by region. This differentiation has been done to understand the market at all levels. The differentiated ...

Emerging Liquid Biopsy Market Emerging Liquid Biopsy Market Recent advances in genotyping and sequencing technologies are - Market research report and industry analysis - 9723929

The Liquid Biopsy Tracker is a customizable competitive intelligence tool, which aggregates relevant secondary data to populate a tracking database, monitoring the emerging liquid biopsy space across crucial parameters. The tool consolidates a range of disparate sources of data, enabling the extraction of vital competitive insights to answer essential business questions.. Fill out the form below to download a sample from the competitive intelligence tool. ...

Liquid Biopsy: Labordiagnostik in Deutschland - Untersuchungsdauer - Kosten | weitere Informationen zur Liquid Biopsy unter Tel.: +49.89.895578-0

Liquid Biopsy: Labordiagnostik in Deutschland - Untersuchungsdauer - Kosten | weitere Informationen zur Liquid Biopsy unter Tel.: +49.89.895578-0

2019 Global Forecast for Liquid Biopsy (2020-2025 Outlook)-High Tech & Emerging Markets Report The 2019 Global Forecast for Liquid Biopsy (2020-2025 Outlook)-High Tech & Emerging - Market research report and industry analysis - 12368993

The nanopillar chip captured more than 10 times the amount of cells captured by the currently used flat structure, said lead study author Dr. Shutao Wang, a postdoctoral researcher at both the Crump Institute for Molecular Imaging at the David Geffen School of Medicine at UCLA and the California NanoSystems Institute at UCLA. Wang noted that the nano-size scale and the unique surface topography of the UCLA nanopillar chip may help it interact with nano-size components on cellular surfaces in the blood, enhancing capture efficiency. The time required for CTC detection using CellSearch, a technology currently approved by the U.S. Food and Drug Administration, is upwards of three to four hours, according to study author Dr. Hao Wang, a postdoctoral researcher at the Crump Institute and the California NanoSystems Institute at UCLA. The UCLA study found an optimal detection time of only two hours using nanopillar chips. The nanopillar chip uses a common chamber slide, which fits into standard ...

Circulating tumor cells have been shown to be prognostic of survival in metastatic breast, colon, and prostate cancers. Additionally, CTCs are of interest because they may be representative of the phenotype/genotype of the primary and metastatic tumors, and may be a useful tool (i.e. patient stratification) for drug development. CTCs, as liquid biopsies are potentially useful as a PD marker as it allows easy repeat sampling before and after drug treatment. We describe the development of a CTC assay that measures the induction of pHH3 by LY2523355, a selective small molecule inhibitor of the human Eg5 kinesin. pHH3 is a biomarker of mitosis. In tumor xenograft mouse models, LY2523355 treatment was shown to reduce tumor volume with elevation of pHH3 in tumors. The CTC assay was developed using the FDA cleared Veridex/CellSearch™ instrument and reagents for enumeration of CTCs from blood. CellSearch defines CTCs as EpCam+/DAPI+/CK 8, 18, 19+/CD45−. For assay development, cells from tumor cell ...

Abstract #5024 Background: An elevated Circulating Tumor Cell Count (CTC) ,5 in 7.5 ml of blood predicts worse outcome in metastatic breast cancer (MBC) patients (pt). While the FDA has approved use of this test, its systematic use in practices has been uncommon. We have measured CTCs in all MBC pts in our community oncology practice receiving hormonal therapy or chemoRx +/- biologic therapies to determine if a strategy to treat all pts to a sustained CTC count of , 5 could decrease the death rate, and if recognized molecular subsets of breast cancer [ER+, HER2 (H2)-; Triple Negative; H2+] have different patterns of CTC behavior. Methods: Initially serial CTC levels were measured by the CellSearch technology (Veridex, LLC; Warren NJ) using two commerical laboratories in all pts whether beginning a new therapy with initial recurrence or progression, or if already underway with treatment. Pts had CTCs measured from Nov 20, 2006 thr. June 10, 2008, an 18 mo. period Over time, the majority of pts ...

BREAST CANCER CELLS IN THE BLOOD PREDICT HIGH RISK OF RECURRENCE. During my time in the lab, as a research fellow at the John Wayne Cancer Institute, I completed several research studies that revealed a powerful link between the presence of tiny numbers of cancer cells floating in the blood and overall survival in patients without any evidence of recurrent cancer by standard laboratory and radiographic tests. In these research studies, we used a powerful test, reverse transcriptase-polymerase chain reaction (RT-PCR) to detect fragments of genetic material from otherwise undetectable cancer cells in the blood of patients with a prior history of cancer. (RT-PCR, which can detect the presence of a single tumor cell floating amongst more than a million normal blood cells, is a powerful tool for detecting trace numbers of cancer cells present in the blood, bone marrow, lymph nodes, and other tissues of the body.). A newly published RT-PCR research study appears in the current issue of the British ...

Microchip Captures Clusters of Circulating Tumor Cells. Circulating tumor cells (CTCs) are cells that break away from a tumor and move through a cancer patients bloodstream. Single CTCs are extremely rare, typically fewer than 1 in 1 billion cells. These cells can take up residence in distant organs, and it is believed that this is one mode by which cancer spreads. Even less common than single CTCs are small groups of CTCs, or clusters. While the existence of CTC clusters has been known for more than 50 years, their prevalence in the blood as well as their role in metastasis has not been thoroughly investigated, mostly because they are so elusive. However, recent advances in biomedical technologies that enable the capture of single CTCs have renewed interest in CTC clusters, which are occasionally captured along with single CTCs.. According to an article published online in Nature Methods Researchers (18 May 2015) a microfluidic chip has been developed that can capture rare clusters of ...

Purpose:. Circulating tumor cell (CTC) enumeration or Androgen Receptor (AR) splice variant 7 expression from Epithelial Cell Adhesion Molecule (EpCAM) positive CTCs are predictive biomarkers for patients with prostate cancer. Recent reports suggest subpopulations of CTCs with decreased EpCAM expression may have greater invasive capacity or drug-resistant potential. These include cells with mesenchymal phenotypes that express N-cadherin, or MUC1, or stem cell populations that express CD133. Integrated molecular analysis across different CTC subpopulations has not been performed. We sought to compare the molecular profile of different populations of CTCs from the blood of patients with prostate cancer.. Methods:. A multiparametric flow cytometry assay was used to identify different populations of CTCs from patients with prostate cancer. We then employed an integrated CTC capture and analysis technology known as the VERSA (Versatile Exclusion-based Rare Sample Analysis) platform to in parallel or ...

Thermo Fisher Scientific offers end-to-end solutions to help you make the most of limited material in liquid biopsy cancer research. Whether you are looking at multiple targets, or just a few, our NGS solutions combine the power of Ion Torrent technology with advanced rare cell isolation, manual or automated cell-free DNA extraction, targeted NGS assays, and digital PCR tools. Together, these solutions enable you to retrospectively assess cancer research samples throughout all stages.

The total personalised targeted therapeutic market, for all indications, will grow at a CAGR of 6.47% over the next five years. Strong vertical growth in the companion diagnostic segment however will see a CAGR of 23.71% to 2020, mainly coming from oncology, cardiovascular and infectious disease (HIV/HCV) tests. Advancing technologies within the liquid biopsy market is also driving the market and will see strategic growth over the next five years with a CAGR of 20.6%. The two segments of the liquid biopsy market are tumor cell enrichment products and tumor cell detection technologies ...

The mystery of unexpectedly low numbers of CTCs in a liquid biopsy may be explained by whether the blood is drawn from a vein or an artery.

Scientists reported the development of a robust procedure for whole-genome copy number profiling of circulating tumor cells (CTCs) from a blood test. In contrast to existing methods that are complex and costly, the single-tube, single-step protocol detect absolute copy number alterations (CNA) in single cells and maintain accuracy at a lower cost than conventional genomic analysis procedure, opening up to the possibility for genome-driven targeted therapy selection and monitoring of disease progression in liquid biopsy.

Turning back to cancer-related trends, sometimes its the smallest of advances that has the biggest impact. Take for example the topic of liquid biopsies.. The topic is trending, but still pulling low media rating numbers. Liquid biopsies is up + 3 points or 8 percent at a moderate 39 rating in the Science Sector. 4-year media momentum has been consistently positive with a few exceptions in early 2014. The topic hit a critical media momentum trigger in July 2012 that ignited an amazing media run.. Cumulative 4-year media growth is the key metric here. At +31 percent, liquid biopsies has been trending under the mainstream media radar for nearly 4-years straight.. For a little background liquid biopsies are a new type of blood test that is starting to transform cancer treatment, sparing some patients the surgical and needle biopsies long needed to guide their care.. The tests, called liquid biopsies, capture cancer cells or DNA that tumors shed into the blood, instead of taking tissue from the ...

Liquid Biopsy, a blood test that detects circulating DNA tumor DNA, may not only sound an early alert that a treatment effect is diminishing but may also may offer clues about what to do next according to a new study published Researchers say We have shown that integrating regular liquid biopsy into our patient routine care is feasible and easily incorporated into clinical practice. This technology can precisely help us understand each patients individual disease course and allows us to tailor care based on an understanding of their significant disease biology.. In the study 40 patients with various forms of gastro-intestinal (GI) cancers who had previously responded to treatment that stopped were included. Liquid biopsies were done when their disease began to progress and circulating tumor DNA in the blood was analyzed for genetic mutation that might be making patients resistant to treatment. Thirty one of the 40 patients had at least one mutation, and 14 had more than 1 mutation. It was ...

Liquid Biopsy Tests are emerging as a viable alternative to traditional methods for cancer screening. A liquid biopsy is a new type of blood test that has the potential to transform cancer treatment. Using this methodology, physicians avoid the traditional surgical and needle biopsies they use to determine the existence of cancer in patients.

The primary goal of this research is to analyze the current and future adoption patterns on the usage of liquid biopsy. Key information the survey seeks to collect include the following: • Current and future use of liquid biopsy by organization type • Tim

The purpose of the current study is to establish a Liquid biopsy method (positive enrichment by a novel immunomagnetic beads capture assay) for detection of...

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Background Molecular-based companion diagnostic tests are being used with increasing frequency to predict their clinical response to various drugs, particularly for molecularly targeted drugs. However, invasive procedures are typically required to obtain tissues for this analysis. Circulating tumour cells (CTCs) are novel biomarkers that can be used for the prediction of disease progression and are also important surrogate sources of cancer cells. Because current CTC detection strategies mainly depend on epithelial cell-surface markers, the presence of heterogeneous populations of CTCs with epithelial and/or mesenchymal characteristics may pose obstacles to the detection of CTCs.. ...

Abstract: Circulating tumor cells (CTC) in patient blood samples correlate with poor disease-free survival. The objective was to develop a peripheral blood CTC detection method using microfluidic confocal flow cytometry to discriminate cell types based on differences in backscattered light intensity. Cultured breast cancer cells scattered in a unique, intermediate space relative to the two major l... read moreeukocyte classes of mononuclear cells and granulocytes. To discriminate native CTCs, green fluorescent protein-expressing (GFP+) human breast cancer cells were implanted orthotopically in mice. This animal work was conducted in collaboration with a therapeutic target project investigating ADAM8. Mice implanted with ADAM8-knockdown cells had significantly reduced CTC concentrations and brain metastases. Further, anti-ADAM8 antibody treatment of resected tumors decreased metastases and significantly increased a rare population of autofluorescent leukocytes implicated in an immune response. ...

Extracellular vesicles (EVs) have the capacity to shuttle both proteins, lipids and nucleotides such as RNA between cells, leading to an array of functional changes in a recipient cell. Importantly, the EV secretome changes significantly in disease, especially in cancer. We have recently developed a process to isolate EVs specifically from tumor tissues, and have utilized this technology to identify an array of biomarker candidates in malignant melanoma, breast cancer and colon cancer. Specifically, the technique identifies EV surface molecules from tumor tissue EVs, which are not present on plasma EVs from healthy individuals. Using this information, we have been able to develop assays to specifically identify cancer-EVs in the circulation in cancer patients compared to healthy individuals. This presentation will discuss EV diversity, and will give several examples of circulating cancer EV biomarkers that can function as liquid biopsies in cancer subgroup identification, cancer monitoring and ...

Subjects who, through completion of the study, would have donated in excess of 500 mL blood in 14 days, or 500-750 mL blood in 14 days (unless approved by the Principal Investigator, 1000 mL blood in 90 days, 1250 mL blood in 120 days, 1500 mL blood in 180 days, 2000 mL blood in 270 days, 2500 mL blood in 1 year ...

Biocartis has launched two new research-use-only products for its Idylla molecular diagnostics platform. The first product, the Idylla ctBRAF Mutation Assay, uses blood plasma as a sample, and according to the company is the first fully automated liquid biopsy assay that can potentially act as a substitute for tissue biopsy testing in melanoma, colorectal, and lung cancers, as well as conditions such as hairy cell leukemia and histiocytosis. The assay has a turnaround time of approximately 90 minutes with less than one minute of hands-on time.The second product, the Idylla NRAS-BRAF-EGFR S492R Mutation Assay complements the already CE-marked Idylla KRAS Mutation Test. Together, these provide complete metastatic colorectal cancer mutation analysis using two slices of formalin-fixed, paraffin-embedded tumor tissue.

Researchers have described a skin liquid biopsy method that enables T cell isolation from lesional blood from mycosis fungoides patients.

Nanostics news and achievements: Less invasive liquid biopsy, a new test for clinically significant prostate cancer, Falling Walls 2018, BioAlberta Innovator and Entrepreneur Award 2018.

Liquid biopsies can look for signs of cancer in blood or other bodily fluids more quickly than tissue biopsies that typically detect cancer at a later stage.

This guest post from Dr. Wafik El-Deiry of Fox Chase Cancer Center discusses the promise of liquid biopsy in the diagnosis and treatment of cancer.

The number of alterations detected in the DNA collected from blood samples (liquid biopsies) of cancer patients treated with immune checkpoint inhibitors was associated with response to the treatment. Using blood samples from 69 patients with different types of cancer treated with immune checkpoint inhibitor therapy,

The symposium on Liquid Biopsies & Cancer is organised by the Leuven Cancer Institute (LKI), in a joint effort of the KU Leuven and the University Hospitals Leuven.

17. 12. 2019 15:00. A tissue biopsy has long been the preferred method for detecting or monitoring the progress of a cancer disease, but its shortcomings - its both invasive and restricted to a limited region - have led to the development of liquid biopsy based on a simple blood test. I speak with Irena Hudecova, a Slovak scientist working in conjunction with Cambridge University in this fast-growing field.. ...

Fantastic advances in immunotherapy, including CAR T-cells, bispecific antibodies and potential immunotherapy combinations, were presented at the Myeloma 2017 meeting in Edinburgh, UK. In this panel discussion, Keith Stewart, MB, ChB and Leif Bergsagel, MD from the Mayo Clinic, Scottsdale, AZ and Gareth Morgan, MD, FRCP, FRCPath, PhD of UAMS Myeloma Institute, Little Rock, AR discuss the highlights from day 1 of the meeting. In addition to immunotherapy updates, the potential for a similar phenomenon to double hit lymphoma occurring in multiple myeloma (MM), which would identify a distinct MM subgroup in need of different therapies, is discussed. Furthermore, the application of liquid biopsies and molecular diagnostics in the clinic to improve the management of patients with MM is deliberated. Exciting amyloidosis updates are also touched upon.

In this report, the global Liquid Biopsy Products market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022,...

Liquid biopsies are becoming an attractive source of biomarkers. One of the principle biomarker related to epithelial cancers found in blood is circulating tumor cell (CTC) enumeration of which revealed prognostic value in cancer patients. The challenge associated with CTCs as biomarkers has been the modest clinical sensitivity and specificity demonstrated using the FDA-approved platform. The question arises: does the biology limit the CTC burden or is the analytical platform used for their isolation limiting? Indeed, many microfluidic platforms have shown higher clinical sensitivity compared to the FDA-approved test. CTCs expressing invasive phenotypes down-regulate epithelial antigens, such as the epithelial cell adhesion molecule - EpCAM, which is typically used for the affinity selection of CTCs. It is believe now that CTCs may have a continuum of phenotypes and thus, a single selection marker (i.e., EpCAM) may not address all cells comprising the tumor microenvironment. We have developed a ...

The coagulation-fibrinolysis system is considered to be an important factor in the growth and spread of tumors (Kodama, 1974; Kinjo, 1978). At the advancing border of the tumors, deposition of fibrin...

TY - JOUR. T1 - Presence of minute cancer cell dissemination in peritoneal lavage fluid detected by reverse transcription PCR is an independent prognostic factor in patients with resectable pancreatic cancer. AU - Eguchi, Hidetoshi. AU - Ohigashi, Hiroaki. AU - Takahashi, Hidenori. AU - Yano, Masahiko. AU - Motoori, Masaaki. AU - Miyashiro, Isao. AU - Kishi, Kentaro. AU - Ohue, Masayuki. AU - Noura, Shingo. AU - Seki, Yosuke. AU - Yamada, Terumasa. AU - Goto, Kunihito. AU - Yamamoto, Takashi. AU - Idota, Atushi. AU - Fujii, Junko. AU - Nakajima, Hiromu. AU - Yamasaki, Tomoyuki. AU - Ishikawa, Osamu. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Background: Presence of minute cancer cell dissemination in peritoneal lavage fluid detected by reverse transcription polymerase chain reaction (RT-PCR) has been reported to be a reliable predictor of the prognosis in several kinds of cancers, but has not been determined in pancreatic cancer. Methods: Peritoneal lavage fluid was harvested just after a laparotomy ...

Circulating tumor cells are cells that detach from the primary tumor site and migrate to the bone marrow or other tissues where they can initiate a metastatic site. Liquid biopsies are an emerging tool in the past decades that enables us to detect Circulating Tumor Cells in patients blood. Flow cytometry is a powerful tool used in liquid biopsy diagnostics. This aims to prove the sensitivity and specificity of a flow cytometric panel for the detection of CTCs in breast cancer patients using healthy individuals samples as controls. The study was blinded to the data analyzing researcher. Statistical analysis followed and results show 86.9% area under the curve which indicates that the particular method can be very promising for diagnosing breast cancer.

The potential for circulating tumor cells (CTCs) to elucidate the process of cancer metastasis and inform clinical decision-making has made their isolation of great importance. However, CTCs are rare in the blood, and universal properties with which to identify them remain elusive. As technological advancements have made single-cell deformability measurements increasingly routine, the assessment of physical distinctions between tumor cells and blood cells may provide insight into the feasibility of deformability-based methods for identifying CTCs in patient blood. To this end, we present an initial study assessing deformability differences between tumor cells and blood cells, indicated by the length of time required for them to pass through a microfluidic constriction. Here, we demonstrate that deformability changes in tumor cells that have undergone phenotypic shifts are small compared to differences between tumor cell lines and blood cells. Additionally, in a syngeneic mouse tumor model, cells ...

Very early in the development of the Vortex technology, strong partnerships were developed with oncology clinicians, Dr. Jonathan Wade Goldman from UCLA and Dr. Stefanie S. Jeffrey from Stanford University. Because of these collaborations, the Vortex team has been able to work with samples from patients with colorectal, lung and breast cancer. Sollier-Christen feels strongly that access to blood from cancer patients and age-matched controls are great assets in testing and validating Vortexs technology.. Sollier-Christen has a personal interest in the diagnosis and treatment of cancer and finds this passion very common among the people in her company and others working in the oncology realm. I know Vortex Biosciences would not be where we are today without supportive people from the beginning, she says. Of course, you need a strong technology, a good market, and the technology needs to answer a crucial need. But you must have a strong team.. Early investors enabled Sollier-Christen and Di ...

Researchers studied isolated CTCs along with real-world patient data and found that patients with blood-borne HER2 mutations may respond to anti-HER2 treatment.

During the last decade, isolation of circulating tumour cells via blood liquid biopsy of prostate cancer (PCa) has attracted significant attention as an alternative, or substitute, to conventional diagnostic tests. However, it was previously determined that localised forms of PCa shed a small number of cancer cells into the bloodstream, and a large volume of blood is required just for a single test, which is impractical. To address this issue, urine has been used as an alternative to blood for liquid biopsy as a truly non-invasive, patient-friendly test. To this end, we developed a spiral microfluidic chip capable of isolating PCa cells from the urine of PCa patients. Potential clinical utility of the chip was demonstrated using anti-Glypican-1 (GPC-1) antibody as a model of the primary antibody in immunofluorescent assay for identification and detection of the collected tumour cells. The microchannel device was first evaluated using DU-145 cells in a diluted Dulbecco’s phosphate-buffered saline

A chip developed by mechanical engineers at Worcester Polytechnic Institute (WPI) can trap and identify metastatic cancer cells in a small amount of blood drawn from a cancer patient. The breakthrough technology uses a simple ...

Cancer is among the leading causes of death worldwide. While primary tumors are often treated effectively, they can spawn secondary cancers called metastases which dramatically decrease chances of survival. In order to develop successful therapies, it is thus crucial to estimate the time until metastases appearance and improve our ability to detect primary tumors before metastases are generated. The estimation of the time to cancer recurrence depends on the dynamics of tumor growth and metastases seeding. For early detection, promising results have recently been obtained with liquid biopsies, id est the analysis of specific biomarker levels in blood samples. This thesis investigates these problems by studying mathematical models of cancer evolution and liquid biopsies based on the theory of branching processes. Firstly, we consider first passage times to a given size in branching birth-death processes. We derive their probability distribution and first moments conditioned on non-extinction, ...

One of the cruelest truths about cancer is that even after you beat the disease, it can still come back to kill you. A tumor growing in the prostate gland, breast, or any other organ can shed cancerous cells into the blood. These cancerous seeds travel the body and can take root nearly anywhere, growing into a new cancer threat even after the initial cancer is treated.. The rule of thumb with cancer is that the earlier you can detect the disease, the more effective the treatment, and hence better potential outcomes.. Currently, doctors draw a patients blood and analyze it using special antibodies to detect the presence of the seeds, called circulating tumor cells (CTCs). This works well if CTCs are present in large numbers, but may fail to detect smaller numbers released by earlier tumors.. Now, a team of engineers, scientists and doctors from Stanford is developing a mini-microscope that might be able to noninvasively detect the CTCs earlier than ever, allowing for earlier ...

Arteries contain higher numbers of circulating tumor cells than veins in uveal melanoma patients, raising a concern for standard technique for detection of tumor cells in the blood.

Arteries contain higher numbers of circulating tumor cells than veins in uveal melanoma patients, raising a concern for standard technique for detection of tumor cells in the blood.

A fundamental task in precision oncology is to perform mutation profiling of tumors, which traditionally requires invasive tumor biopsy. Liquid biopsy, which requires a simple blood draw, provides a surrogate option for tumor biopsy. Liquid biopsy is noninvasive, repeatable, and especially useful when a tumors location makes tissue biopsy unfeasible.. However, the mutation profiling of cell-free DNA (cfDNA) is challenging, as conventional mutation callers are primarily designed for the mutation calling of genomic DNA. Unlike tumor biopsy, cfDNA is a mixture of DNA derived from tumors and that from normal cells, where tumor-derived cfDNA accounts for a minor fraction. As a result, mutations from tumors have weak signals in blood samples and are therefore hard to identify using conventional methods.. To address this challenge, in our recent work published in Nature Communications [1], we present cfSNV, a cfDNA somatic single nucleotide variant (SNV) caller with five innovative techniques to ...

An international team of researchers at University of California San Diego School of Medicine and Moores Cancer Center, with colleagues at Sun Yet-sun University Cancer Center and other collaborating institutions, have developed a new diagnostic and prognosis method for early detection of hepatocellular carcinoma (HCC), based on a simple blood sample containing circulating tumor DNA.

The test developed entirely by MedGenome, is the only one to be validated in India and verified from samples of cancer patients from across the country. The test screens the samples by analyzing cell-free DNA that is isolated from the patients blood. Using high end sequencing technology, the screening process identifies specific gene mutations that are linked with Melanoma, Lung and Colon cancers. The test facilitates detection of mutation where there is difficulty of obtaining biopsy or in the event of a damaged biopsy material and non-availability of tissue biopsy. This offers Oncologists the power to look for actionable alterations in a patients treatment, management, without having to do an invasive biopsy or where biopsy is not an option ...

Rohini, a 49- year old housewife, was diagnosed with a rare form of cancer (Leiomyosarcoma) in March 2016, after she noticed pain in legs along with swelling, that led to difficulty in walking. Unfortunately, there are not many standard treatment options for Leiomyosarcoma. Hence despite three lines of chemotherapy, which also had side-effects such as toxicity, the disease progressed to her liver and forearm.. Surgery and radiotherapy were ruled out due to the location of the cancer. Current medical knowledge and guidelines failed to provide any insight on how this cancer could be cured. Under these circumstances Rohini was advised to start palliative treatment, which would do little to rid the cancer or to prevent it from spreading. While the patient was otherwise healthy, her disease appeared to be incurable. DCGL carried out comprehensive genetic and cellular testing of the patients tumor and blood samples and selected a customized treatment for this patient.. Within 30 days of receiving ...

Immunotherapy has changed the treatment paradigm for patients with cancer, but patient selection, response assessment and treatment duration require further refinement. A recent study reports that the kinetics of circulating tumor DNA reflect response and resistance to immunotherapy treatment across multiple cancer types and could be used to tailor treatment.

latest releases: ✓ European Medicines Agency Validates Application for Tepotinib for the Treatment of Advanced NSCLC with METex14 Skipping Alterations ✓ Commemorative publication for the 25th anniversary of the IZB presents 70 profiles and visions of successful biotech start-ups ✓ ISET® test results show substantial improvement in early detection of prostate cancer by identifying PSA-positive Circulating Tumor Cells ✓ Merck Advances Oncology Portfolio and Pipeline with New and Long-term Data in Multiple Cancers at ESMO 2020

Retinoblastoma is a tumor of the retina that generally affects children under 5 years of age. If not diagnosed early, retinoblastoma may result in loss of one or both eyes and can be fatal. Unlike most cancers that are diagnosed using a biopsy, retinoblastoma tumors cannot be directly biopsied.

The Journal of Thoracic Disease (JTD, pISSN: 2072-1439; eISSN: 2077-6624) publishes manuscripts that describe new findings in the field provide current, practical information on the diagnosis and treatment of conditions related to thoracic disease (lung disease, cardiology and esophagus disease).

Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.

Oncotarget | https://doi.org/10.18632/oncotarget.16435 Mariano Provencio, Marta Rodríguez, Blanca Cantos, Pilar Sabín, Cristina Quero, Francisco R. García-Arroyo, Antonio Rueda, Constanza Maximiano, Delvys...

Market Scenario: Biopsy involves extracting a sample of tissue and testing it for the presence of diseases especially cancer. Traditional tissue biopsy is

SomaGenics announced the receipt of a Phase I SBIR grant from the National Human Genome Research Institute to support extension of its RealSeq platform to the sequence analysis

A new approach to RNA sequencing reveals thousands of previously inaccessible RNA fragments in blood plasma that might serve as disease- and organ-specific biomarkers

Circulating Tumor Cells- Circulating tumor cells (CTCs) are neoplastic cells that have been shed into the circulation. Such cells show promise not only as a biomarker for risk in patients with pancreatic cancer but also as a tool to understand the process of systemic spread and metastasis. These studies are critical, as it is metastasis that ultimately leads to death in most patients with pancreatic cancer. Much of this work is done in collaboration with Dr. Chris Wolfgang in the Department of Surgery at Johns Hopkins.. ...

First Prize, BMA Medical Book Awards 2013Breast cancers are now detected earlier and are thus more likely to be confined to the breast itself and regional nodes. Many of these tumours will have minimal proclivity for hematogenous dissemination and…