Definition of Secondary malignant neoplasm in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Secondary malignant neoplasm? Meaning of Secondary malignant neoplasm as a legal term. What does Secondary malignant neoplasm mean in law?
In a comprehensive review and meta-analysis of the currently available literature covering 16,502 patients with thyroid cancers, the relative risk for the development of leukemia was increased 2.5-fold in patients treated with radioiodine.22 In line with this, thyroid cancer was also identified as the second most common primary neoplasm arising in patients who developed tAML following treatment for solid cancers.7 Still, data on patients with therapy-related myeloid neoplasms following radioiodine treatment have been scarce so far, comprising case reports on a total of only 33 patients.. Our analysis shows that the great majority of patients developing therapy-related myeloid neoplasms following radioiodine treatment already present with AML or high-risk MDS as reflected by blast count, karyotype, IPSS or rapid disease progression. These patients do, therefore, share major biological characteristics with patients with tMDS/tAML following chemotherapy, radiation or radiochemotherapy, as indicated ...
Ojha, Rohit P. Hematologic malignancies following external beam radiation therapy for localized prostate cancer. Doctor of Public Health (Epidemiology), December 2010, 88 pp., 6 tables, 2 illustrations, references, 96 titles. The incidence of hematologic malignancies following external beam radiation therapy (EBRT) among prostate cancer patients has received limited attention despite evidence that radiation has a role in leukemogenesis and myelomagenesis. Therefore, we investigated the effect of external beam radiation therapy on acute myeloid leukemia and myeloma incidence among prostate cancer patients. We utilized the Surveillance, Epidemiology, and End Results database to identify a cohort of men (n=168,612) with newly diagnosed prostate adenocarcinoma between January 1988 and December 2003. Cox proportional hazard regression was used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of acute myeloid leukemia and myeloma incidence following definitive
Women with a diagnosis of breast cancer are at increased risk of second primary cancers, and the identification of risk factors for the latter may have clinical implications. We have followed-up for 11 years 10,045 women with invasive breast cancer from a European cohort, and identified 492 second primary cancers, including 140 contralateral breast cancers. Expected and observed cases and Standardized Incidence Ratios (SIR) were estimated using Aalen-Johansen Markovian methods. Information on various risk factors was obtained from detailed questionnaires and anthropometric measurements. Cox proportional hazards regression models were used to estimate the role of risk factors. Women with breast cancer had a 30% excess risk for second malignancies (95% confidence interval-CI 18-42) after excluding contralateral breast cancers. Risk was particularly elevated for colorectal cancer (SIR, 1.71, 95% CI 1.43-2.00), lymphoma (SIR 1.80, 95% CI 1.31-2.40), melanoma (2.12; 1.63-2.70), endometrium (2.18; ...
Results:. Fifty-five patients (10%) were free of cancer 2 years after initiation of therapy. Eighteen of these patients developed one or more second primary cancers, including 13 who developed second primary non-small-cell lung cancer. The risk for any second primary cancer compared with that in the general population was increased four times (relative risk, 4.4; 95% CI, 2.5-7.2), with a relative risk of a second primary non-small-cell lung cancer of 16 (CI, 8.4-27). Forty-three patients discontinued smoking within 6 months of starting treatment for small-cell lung cancer, and 12 continued to smoke. In those who stopped smoking at time of diagnosis, the relative risk of a second lung cancer was 11 (CI, 4.4 to 23), whereas, in those who continued to smoke, it was 32 (CI, 12 to 69). ...
Patients in the present study had a median overall survival of 25.08 years, consistent with the reported survival of patients in the SEER database. In our study, patients with SPMs had a median survival of 3.77 years following SPM diagnosis, and the average interval between the first and second cancers was 6.27 years (SD = 5.53 years). The highest risk of developing SPM was observed in the first 5 years after diagnosis of uterine cancer, largely because of an extremely increased risk in the first year (Table 3). The close follow-up during the first year following the diagnosis may have contributed to an earlier detection of second malignancies, leading to a surveillance bias. Moreover, recommendations regarding screening should consider this observed latency pattern. Screening and preventive strategies for SPMs are essential for reducing mortality rates. However, no universal guidelines for SPM surveillance in patients with uterine cancer have been established to date. A major obstacle has been ...
The BiRD study also explored this issue.5 BiRD was a small phase II trial involving 72 patients, median age 63 years, with newly diagnosed multiple myeloma. Patients were treated with lenalidomide, clarithromycin, and dexamethasone until progressive disease, stem cell transplantation, or unacceptable toxicity. At baseline, 8 patients had prior solid tumors, 2 had skin cancers, and 1 had lymphoma.. At a median follow-up of 6 years, median progression-free survival was 70.8 months and median 4-year overall survival was 82.2%; median 5-year overall survival had not yet been reached. Follow-up at 5 years revealed five new primary solid tumors and no new hematologic malignancies.. Progression-free survival remains encouraging; frequency of second primary malignancies was low and similar to that reported in the Surveillance, Epidemiology, and End Results (SEER) database for people of similar age, said presenting author Adriana Rossi, MD, Weill-Cornell Medical College, New York. "Routine screening and ...
Introduction: While it has been reported that the risk of contralateral breast cancer in patients from BRCA1 or BRCA2 positive families is elevated, little is known about contralateral breast cancer risk in patients from high risk families that tested negative for BRCA1/2 mutations. Methods: A retrospective, multicenter cohort study was performed from 1996 to 2011 and comprised 6,235 women with unilateral breast cancer from 6,230 high risk families that had tested positive for BRCA1 (n = 1,154) or BRCA2 (n = 575) mutations or tested negative (n = 4,501). Cumulative contralateral breast cancer risks were calculated using the Kaplan-Meier product-limit method and were compared between groups using the log-rank test. Cox regression analysis was applied to assess the impact of the age at first breast cancer and the familial history stratified by mutation status. Results: The cumulative risk of contralateral breast cancer 25 years after first breast cancer was 44.1% (95%CI, 37.6% to 50.6%) for ...
Title:Secondary Neoplasms in Children Treated for Cancer. VOLUME: 13 ISSUE: 1. Author(s):Rejin Kebudi* and Gul Nihal Ozdemir. Affiliation:Istanbul University, Cerrahpasa Medical Faculty & Oncology Institute, Pediatric Hematology- Oncology Dept., Istanbul. Keywords:Cancer, children, chemotherapy, radiotherapy, secondary malignant neoplasms.. Abstract:The survival of children with cancer has improved dramatically in the last decades. Survivors of childhood cancer are at increased risk of long-term complications of therapeutic exposure. Second malignant neoplasms are one of the most severe side effects of cancer treatment. The frequency and type of secondary cancers may vary depending on the initial diagnosis, treatment administered and genetic predisposition. This review highlights the risk factors in the development of SMNs in survivors of pediatric cancers and their differences according to primary cancer type, genetic predisposition and treatment admistered. Finally, the review emphasizes the ...
Lung cancer is the most common second primary cancer. We investigated whether the TNF-a-308 and TNF-a-238 polymorphisms were associated with the susceptibility and severity of lung cancer as the second primary cancer (LC2). Material/Methods: This study included 104 patients from the group LC2. The control subjects included 2 groups. The first control group (LC1) comprised 201 unrelated patients with lung cancer as a first primary cancer. The second control group (HC) comprised 230 healthy blood donors, matched for sex and age to the study group. Results: The frequencies of the TNF-a-238 polymorphism GG genotype and the G allele were higher in the LC2 group than in the LC1 group, but the differences did not reach significance (p=0.054 and p=0.057, respectively). Similar differences were found in the TNF-a-238 polymorphism GG genotype and G allele between the LC2 group and the HC group (p=0.054 and p=0.057, respectively). In terms of the different types of lung cancer, patients with a second ...
Adult; Aged; Breast Neoplasms; Case-Control Studies; Denmark; Female; Humans; Lung Neoplasms; Middle Aged; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Risk ...
Background The purpose of this study was to present the clinicopathological features of a series of patients with human papillomavirus (HPV)-associated head and neck second primary tumors. Methods Patients with HPV-associated head and neck second primary tumors from 3 centers were identified. HPV infection was evaluated using p16 by immunohistochemistry (IHC), high-risk HPV DNA by in situ hybridization (ISH), and HPV genotyping by DNA polymerase chain reaction (PCR) enzyme immunoassay (EIA). Results Eleven patients were identified: 5 with synchronous and 6 with metachronous HPV-positive second primary tumors, the latter demonstrating a mean time interval of 5 years. There were 13 second primary tumors: 11 oropharyngeal, 1 nasopharyngeal, and 1 floor of the mouth. Nine of 10 genotyped patients harbored HPV-16, and 1 patient had HPV-33 in 3 synchronous tumors. Conclusion HPV-associated second primary tumors may present as synchronous and/or metachronous lesions and can arise outside the oropharynx ...
Survivors of breast cancer have a one in six chance of developing breast cancer in the other breast. But a study conducted in mice suggests that survivors can dramatically reduce that risk through treatment with moderate doses of radiation to the unaffected breast at the same time that they receive radiation therapy to their affected breast. The treatment, if it works as well in humans as in mice, could prevent tens of thousands of second breast cancers.
Health, ...A group of international researchers has found the first reliable evid...According to the research published online today (Wednesday 18 March) ...Until now the impact of early detection of second breast cancers was ...The current study looked at 1044 women who had attended one clinical ...,Early,detection,of,second,breast,cancers,halves,womens,risk,of,death,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Purpose: Evolving therapies have improved the prognoses of patients with breast cancer; and currently, the number of long-term survivors is continuously increasing. However, these patients are at increased risk of developing a second cancer. Thus, late side effects are becoming an important issue. In this study, we aimed to investigate whether patient and tumor characteristics, and treatment type correlate with secondary tumor risk. Methods: This case-control study included 305 patients with a diagnosed second malignancy after almost 6 months after the diagnosis of primary breast cancer and 1,525 controls (ratio 1:5 of cases to controls) from a population-based cohort of 6,325 women. The control patients were randomly selected from the cohort and matched to the cases according to age at diagnosis, calendar period of diagnosis, disease stage, and time of follow-up. Results: BRCA1 or BRCA2 mutation, human epidermal growth factor receptor 2 (HER2)+ status, chemotherapy, and radiotherapy were ...
Background: We conducted a systematic review and meta-analysis of existing data from observational studies to assess the strength of the association of alcohol drinking with second primary cancer risk in patients with upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) cancer.. Methods: PubMed and Embase were searched up to July 2012 and the reference lists of studies included in the analysis were examined. Random-effects models were used to estimate summary relative risks (RR) and 95% confidence interval (CI).. Results: Nineteen studies, 8 cohort and 11 case-control studies, were included. In highest versus lowest meta-analyses, alcohol drinking was associated with significantly increased risk of UADT second primary cancers (RR, 2.97; 95% CI, 1.96-4.50). Significantly increased risks were also observed for UADT and lung combined (RR, 1.90; 95% CI, 1.16-3.11) and all sites (RR, 1.60; 95% CI, 1.22-2.10) second primary cancers. For an increase in the alcohol intake of 10 ...
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Patient Presentation A 17-year-old female was admitted after surgical biopsy for a workup and treatment planning for a suspicious lesion in her pelvis diagnosed after a 3 week history of right hip pain. The past medical history revealed treatment for localized Ewing sarcoma of her right femur at age 9 after presenting with pain and…
This document describes, among other things, systems and methods for characterizing a tachyarrhythmia. A method comprises obtaining a current first primary characterization of the tachyarrhythmia and a current first primary confidence level of the current first primary characterization, obtaining a current second primary characterization of the tachyarrhythmia and a current second primary confidence level of the current second primary characterization, and determining a current secondary characterization using the current first primary characterization, the current first primary confidence level, the current second primary characterization, and the current second primary confidence level.
NanoString Technologies is now officially in the diagnostics business. Seattle-based NanoString is announcing today that it has begun selling its first
Your baby will become more proficient at breastfeeding as the first month progresses. Expect to feed your baby about eight to 12 times in 24 hours and for approximately 10 to 30 minutes at the first breast before he/she lets go of the breast without your help. You can then burp the baby, change his/her diaper, and switch to the second breast. Usually, a baby will breastfeed for a shorter period at the second breast, and sometimes he/she may not want to feed on the second breast at all. Simply offer the second breast first at the next feeding. Babies that guzzle their food nonstop may self-detach in 10 to 15 minutes; babies preferring to savor their meals often take 20 to 35 minutes on the first breast, because they tend to take a few several-minute breaks between "courses." Whichever type your baby is, it is important to let him/her choose when to let go of the breast, as this self-detachment will increase the amount of higher fat/higher calorie milk (hindmilk) your baby takes in.. ...
Your baby will become more proficient at breastfeeding as the first month progresses. Expect to feed your baby about eight to 12 times in 24 hours and for approximately 10 to 30 minutes at the first breast before he/she lets go of the breast without your help. You can then burp the baby, change his/her diaper, and switch to the second breast. Usually, a baby will breastfeed for a shorter period at the second breast, and sometimes he/she may not want to feed on the second breast at all. Simply offer the second breast first at the next feeding. Babies that guzzle their food nonstop may self-detach in 10 to 15 minutes; babies preferring to savor their meals often take 20 to 35 minutes on the first breast, because they tend to take a few several-minute breaks between "courses." Whichever type your baby is, it is important to let him/her choose when to let go of the breast, as this self-detachment will increase the amount of higher fat/higher calorie milk (hindmilk) your baby takes in.. ...
Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the womens environment, cancer and radiation epidemiology study Academic Article ...
Health, ...TUESDAY Sept. 20 (HealthDay News) -- Black women who develop breast c... When the disease does occur in blacks early on it tends to be more a...The investigators also found that overall diagnoses of breast cancer a... While the incidence of breast cancer is generally higher among whites...,Higher,Risk,of,Second,Breast,Cancer,Seen,in,Black,Women,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
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Our recent study (1) is the largest of many of different designs aimed at investigating the relationship between Nonmelanoma skin cancer (NMSC) and subsequent primary malignancies. Our results are in line with the most comprehensive systematic review on this relationship: it reported significantly increased overall relative risks in 15 of its 21 studies (2).. It is true that we were unable to adjust for smoking, BMI (as a marker of dietary fat intake), alcohol intake and UV exposure. However, cohort studies adjusting for individual level data on smoking, alcohol, BMI, skin color, and a number of other risk factors (3, 4) also show an increased cancer risk after NMSC.. In his own meta-analysis (5), Grant adjusts for the relative risk of lung cancer as a crude proxy for smoking, despite the lack of definitive evidence linking smoking with NMSC. He states that the decreased risks he finds for four cancers after NMSC are "nearly direct evidence that solar UVB reduces the risk of many internal ...
Among patients who have relapsed or have experienced a subsequent malignancy other than non-melanomatous skin cancer since their original diagnosis, the study committee will review the available data (both from Childrens Oncology Groups [COGs] Statistics and Data Center [SDC] and the participating institution) to determine if individual patients are to be selected for Stratum 2; in recognition that local institutions sometimes have more updated relapse/subsequent cancer data than SDC, in cases where local data is more updated, local data will be used preferentially; the study will petition the Institutional Review Board (IRB) specifically for a waiver of consent to include any relapse and subsequent cancer data obtained from existing records for analysis of the secondary aims; patients selected for Stratum 2 will be those for whom late relapse or subsequent cancer is reported but who lack clear confirmation in existing records (either at SDC or at the local institution ...
Among patients who have relapsed or have experienced a subsequent malignancy other than non-melanomatous skin cancer since their original diagnosis, the study committee will review the available data (both from Childrens Oncology Groups [COGs] Statistics and Data Center [SDC] and the participating institution) to determine if individual patients are to be selected for Stratum 2; in recognition that local institutions sometimes have more updated relapse/subsequent cancer data than SDC, in cases where local data is more updated, local data will be used preferentially; the study will petition the Institutional Review Board (IRB) specifically for a waiver of consent to include any relapse and subsequent cancer data obtained from existing records for analysis of the secondary aims; patients selected for Stratum 2 will be those for whom late relapse or subsequent cancer is reported but who lack clear confirmation in existing records (either at SDC or at the local institution ...
[Second neoplasms after percutaneous radiotherapy]. Urologe A. 2016 Nov 14; Authors: Haidl F, Pfister D, Semrau R, Heidenreich A Abstract Radiation therapy represents an alternative treatment to radical prostatectomy in the management of clinically localized prostate cancer. Radiation-induced second neoplasms are defined by a latency period of at least 5 years, loca...
The primary objective of this clinical trial is to evaluate the safety and tolerability of RO5185426 in patients with metastatic melanoma (surgically incurable and unresectable stage IIIC or Stage IV, AJCC) harboring the BRAF V600 mutation (identified by the cobas® 4800 BRAF V600 Mutation Test). Hence the following safety variables are primary variables: adverse events (all AEs, AEs grade 3 or 4, AEs of special interest, AEs leading to drug interruptions or discontinuations, serious adverse events (SAEs), dermatological evaluations and other assessments for SCC (chest CT scan, anal examination, cervical examination and head/neck examination), assesment for second primary malignancies, premature discontinuation from study and treatment, laboratory parameters and study medication ...
The head and neck cancer Patient Concerns Inventory (PCI-HN) is a holistic, self-reported list of items that can help patients to disclose their needs and concerns during routine follow-up consultations. The aim of this study was to report how often it was used during the first three years of follow up after treatment for oral cancer, and the range of issues that were raised. The sample comprised consecutive patients treated over a three-year period with curative intent. All clinic attendances were reviewed until October 2015 or until patients had a recurrence, a subsequent primary, metastases, or were discharged home or to follow up at a peripheral hospital, or started palliative care ...
POST OP mastectomy and removing 10 lymph nodes. Microscopy reported that ductal carcinoma with metastasis axillary lymph nodes. It had same histology with cancer right breast 10 years before, so it was second breast cancer, a contralateral breast cancer after 10 years ...
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MEMPHIS, Tenn. -- Children and adolescents who survive acute lymphoblastic leukemia (ALL) may need a lifetime of follow-up due to elevated risk of secondary neoplasms that continues to climb through a
Lung window of same patient. The nodule to the left is residual non-small cell Ca and is smaller than noted in a similar study of just 3 months prior.
Id like to know what kind of smoking habit she had that coughing up the first tumor was something she thought nothing of. I mean, if I coughed up something bigger than a tiny droplet of spit Id be at the hospital faster than you could say beam me up ...
Seconde Tumeur Primitive 0 questions Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. ...
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Intellikine has only been cooking up new drugs in the laboratory for a little more than two years, and now its first candidate is being tested in human bei
The ICD-10 Code C71 is the code used for Malignant neoplasm of brain .An alternative description for this code is Malignant neoplasm of ...
Looking for online definition of Secondary malignant neoplasm in the Medical Dictionary? Secondary malignant neoplasm explanation free. What is Secondary malignant neoplasm? Meaning of Secondary malignant neoplasm medical term. What does Secondary malignant neoplasm mean?
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THERAPY-RELATED MYELOID NEOPLASMS (t-MN) OF THE ADULT: MONOCENTRIC OBSERVATIONAL STUDY AND REVIEW OF THE LITERATURE.
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THERAPY-RELATED MYELOID NEOPLASMS (t-MN) OF THE ADULT: MONOCENTRIC OBSERVATIONAL STUDY AND REVIEW OF THE LITERATURE.
Patients who survive Hodgkin lymphoma (HL) are at increased risk of secondary neoplasms (SNs). A wide variety of SNs have been reported, including leukemias, non-Hodgkin s lymphomas, and solid tumors, specifically breast and thyroid cancers. Herein we report subsequent neoplasms in four patients with HL receiving chemoradiotherapy. It is interesting that three SNs, fibrosarcoma, thyroid carcinoma, and retrobulbar meningioma, were observed in the radiation area in one of our patients. A hypopharyngeal epithelioid malignant peripheral nerve sheath tumor as an unusual secondary malignant neoplasm developed in another patient, while a benign thyroid nodule and invasive ductal breast carcinoma were observed at different times in the female patient. Follicular adenoma of the thyroid gland developed in one of our patients.. Keywords: Secondary neoplasms, Chemoradiotherapy, Hodgkin s ...
Patients who survive Hodgkin lymphoma (HL) are at increased risk of secondary neoplasms (SNs). A wide variety of SNs have been reported, including leukemias, non-Hodgkin s lymphomas, and solid tumors, specifically breast and thyroid cancers. Herein we report subsequent neoplasms in four patients with HL receiving chemoradiotherapy. It is interesting that three SNs, fibrosarcoma, thyroid carcinoma, and retrobulbar meningioma, were observed in the radiation area in one of our patients. A hypopharyngeal epithelioid malignant peripheral nerve sheath tumor as an unusual secondary malignant neoplasm developed in another patient, while a benign thyroid nodule and invasive ductal breast carcinoma were observed at different times in the female patient. Follicular adenoma of the thyroid gland developed in one of our patients.. Keywords: Secondary neoplasms, Chemoradiotherapy, Hodgkin s ...
The last decade has experienced a steady increase in the incidence of MPM [16]. With the expected survival of oncology patients prolonged, it is no longer rare to observe a subsequent primary malignancy in long-term follow-up, especially those from therapy-related carcinogenesis [17, 18]. A recently published paper provided by the Surveillance, Epidemiology and End Results Program estimated 7.9% of cancer-survivors were living with a history of more than one primary malignancy in the U. S [16]. The reported prevalence estimated that cancer-survivors were at an increased risk of being diagnosed with a secondary primary malignancy [19-21]. Bhatia et al. showed the risk of second tumor was increased approximately 18 times in survivors of childhood Hodgkins lymphoma [21]. The incidence of second neoplasm in cancer-survivors (2.3%, 68/2909) of our center was in accordance with previous literature [6, 16, 22, 23], which was higher than that of the normal population [1]. We hypothesized that the ...
Colonoscopy is the procedure of choice for the detection of intraluminal metachronous CRCs. Pooled data from studies selected for this review (Supplementary Tables 1 and 2) show that approximately two-thirds of metachronous cancers are asymptomatic, TNM stage I or II (or Dukes stage A or B), and reoperated with curative intent. Data from population-based registries suggest that metachronous CRCs are being diagnosed at earlier stages, possibly reflecting the effect of increased surveillance (48, 65). The cumulative incidence of metachronous cancers of the colon and rectum is estimated to be about 0.3-0.35% per year (5, 60, 66), presenting at any time, even decades after the index malignancy (4, 18, 19, 20, 39, 41, 42, 43, 45, 55, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80). All colorectal segments are at increased risk for a metachronous cancer, although some studies suggest that among older survivors, the risk remains elevated only in the proximal colon (81). Thus, postoperative ...
A video training series providing an overview of important considerations of radiation epidemiology, describing what distinguishes a well-designed or reliable study from an unreliable, and a flawed study. The series explores how the results of epidemiologic studies are misused or misrepresented and the impact on creating public health policy and evidence-based health practices.
Epidemiologic studies of various incidence patterns of multiple primary cancer in patients with cancer have guided research about carcinogenic mechanisms that may apply to several organ sites [1, 2]. At issue is whether risk patterns exist that predict subsequent primary cancer in patients with an index primary cancer of a particular organ and type. Also at issue is whether apparent increases in risk result from 1) shared or common etiologic factors in the pathogenesis of the index and second primary cases of cancer; 2) adverse toxic effects of agents used in the treatment of the index cancer; 3) random or chance effects [for example, those occurring after multiple significance testing]; or 4) spurious associations that are the result of confounding by correlated lifestyle risk factors or by biased ascertainment of new primary cancer as a result of more careful medical surveillance in patients with a history of cancer. The application of criteria for judging the biological plausibility of a ...
Personalized NK Cell Therapy After Chemotherapy and Cord Blood Transplant in Treating Patients With Myelodysplastic Syndrome, Leukemia, Lymphoma or Multiple ...