GenoMEL is an international research consortium working on the genetics of melanoma. At its core are most of the worlds leading melanoma genetics research centres. The consortium has incorporated many new complementary centres and disciplines as part of the Network of Excellence (NoE) programme. New members have been found in the diverse fields of molecular genetics, psycho-oncology, multi-media design and medical ethics.. Our NoE has not only generated research results, but also new ideas, concepts and tools. To capitalise on these diverse products we have formulated a plan for using and disseminating Knowledge.. This Plan ties into the overarching University of Leeds strategy. GenoMEL and its members will benefit by maximising the outcome of their collaborative efforts.. The GenoMEL Plan for using and disseminating Knowledge is available for download from here.. We have also written a short case study of how to disseminate project results via the web. The case study is available ...

The Ras proteins regulate cell proliferation, survival, and differentiation. A specific point mutation in codon 12 converts the H-Ras gene into an active oncogene. Ras gene mutations (H-Ras and N-Ras) have been found in a variety of tumor types, particularly in melanoma ( 18). However, Ras activation in melanocytes is not sufficient to induce melanoma unless the melanoma susceptibility gene INK4a/ARF is lost ( 17). In agreement with this genetic alteration, the majority of sporadic melanomas exhibit inactive INK4a, and melanocytes carrying germ-line deficiencies in the INK4a exhibit a dramatically increased lifetime risk of melanoma ( 19). Mutant Ras activates the Raf/MEK/ERK/AP-1 pathway, which was associated with carcinogenesis. However, the mechanism for Ras activation of this pathway is unclear. For instance, in Ras-transformed melanocytes, B-Raf depletion did not block MEK-ERK signaling or cell cycle progression ( 33). We questioned whether NF-κB is involved in Ras-transformed melanocytes. ...

Here, a novel nonsense protein truncating variant (PTV) in NEK11 p.Arg374Ter was identified as a possible familial melanoma predisposition mutation in a Dutch family. The possibility of any other potentially damaging variants found by WES in this family to either be causal or contributing to the melanoma-risk of this family was considered. Since not enough scientific evidence was available to support a contributing role, these variants were not investigated further.. NEK11 has been initially characterised as a DNA-damage response kinase with two isoforms, the full-length isoform consisting of 645 residues (NEK11-FL) and the short isoform consisting of 470 residues (NEK11-S).37 A regulatory effect during IR-induced G2/M cell-cycle arrest has been described, that is, NEK11 was shown to be involved in phosphorylation of CDC25A triggering its degradation and ultimate blocking of progression into mitosis.27 38 40 NEK11 has been described to (de) regulate G2/M cell-cycle arrest in colorectal carcinoma ...

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.. Yeow, Z.Y.*, Lambrus, B.G.*, Marlow, R., Zhan, K.H., Durin, M., Evans, L.T., Scott, P.M., Phan, T., Park, E., Ruiz, L.A., Moralli, D., Knight, E.G., Badder, L.M., Novo, D., Haider, S., Green, C.M., Turr, A.N.J., Lord, C.J., Chapman, J.R.* and Holland, A.J.* Nature 585(7824). (2020).. [ link ] ...

Some women believe consuming their own placenta in pill form after giving birth is an effective way to treat postpartum depression. Renee Chenault-Fattah reports.. ...

1. Lee Y, Jeon K, Lee JT, Kim S, Kim VN. MicroRNA maturation: stepwise processing and subcellular localization. Embo J. 2002;21(17):4663-4670 2. Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet. 2007;8(2):93-103 3. Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms?. Trends Cell Biol. 2007;17(3):118-126 4. Walker GJ, Indsto JO, Sood R. et al. Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval. Genes Chromosomes Cancer. 2004;41(1):56-64 5. Bemis LT, Chen R, Amato CM. et al. MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. Cancer Res. 2008;68(5):1362-1368 6. Chinnadurai G. The transcriptional corepressor CtBP: a foe of multiple tumor suppressors. Cancer Res. 2009;69(3):731-734 7. Haflidadottir BS, Bergsteinsdottir K, Praetorius C, Steingrimsson E. miR-148 regulates Mitf in ...

Diagnosis of testicular teratoma (costs for program #209283) ✔ University Hospital Düsseldorf ✔ Department of Urology ✔ BookingHealth.com

Surgery treatment of testicular teratoma (costs for program #212661) ✔ Private Hospital Obach ✔ Department of Urology ✔ BookingHealth.com

Bunker, M C., Y-chromosome loss in transplanted testicular teratomas of mice. (1966). Subject Strain Bibliography 1966. 480 ...

© 2015, Springer Science+Business Media Dordrecht. Germline mutations in the exonuclease domain of POLE have been shown to predispose to colorectal cancers and adenomas. POLE is an enzyme involved in DNA repair and chromosomal DNA replication. In order to assess whether such mutations might also predispose to cutaneous melanoma, we interrogated whole-genome and exome data from probands of 34 melanoma families lacking pathogenic mutations in known high penetrance melanoma susceptibility genes: CDKN2A, CDK4, BAP1, TERT, POT1, ACD and TERF2IP. We found a novel germline mutation, POLE p.(Trp347Cys), in a 7-case cutaneous melanoma family. Functional assays in S. pombe showed that this mutation led to an increased DNA mutation rate comparable to that seen with a Pol ε mutant with no exonuclease activity. We then performed targeted sequencing of POLE in 1243 cutaneous melanoma cases and found that a further ten probands had novel or rare variants in the exonuclease domain of POLE. Although this frequency is

The aim of this study is to compare the experience of a group of men with Stage 1 testicular teratomas who were being managed through a surveillance programme (n=25) with a group of patients who had received chemotherapy for more advanced disease (n=22). The study employed a two-phase sequential design that combined quantitative and qualitative methods of data analysis. In the first phase, the hospital anxiety and depression scales (HADS) were used to screen for psychological morbidity. Twelve (48%) of the men assigned to the surveillance programme scored in the borderline or clinical case range on the anxiety subscale of the HADS, compared with six (27%) in the chemotherapy group. There was a significant negative correlation in the surveillance group between time since diagnosis and an elevated anxiety subscale score on the HADS. Interviews were then conducted with 25 participants; a grounded theory approach was used to analyse the transcripts. The hypothesis that human beings are seekers of ...

Soft Tissue Pathology Pathology of Neural Tumours and Tumour-like lesions; Neuroendocrine Carcinoma; Neuroectodermal Tumours presenting in Soft Tissue.. Dr Sampurna Roy MD. ...

Systemic immunosuppression is a risk factor for melanoma, and sunburn-induced immunosuppression is thought to be causal. Genes in immunosuppression pathways are therefore candidate melanoma-susceptibility genes. If variants within these genes individually have a small effect on disease risk, the association may be undetected in genome-wide association (GWA) studies due to low power to reach a high significance level. Pathway-based approaches have been suggested as a method of incorporating a priori knowledge into the analysis of GWA studies. In this study, the association of 1113 single nucleotide polymorphisms (SNPs) in 43 genes (39 genomic regions) related to immunosuppression have been analysed using a gene-set approach in 1539 melanoma cases and 3917 controls from the GenoMEL consortium GWA study. The association between melanoma susceptibility and the whole set of tumour-immunosuppression genes, and also predefined functional subgroups of genes, was considered. The analysis was based on a measure

Scrotal U/S with Doppler Flow The left scrotal sac is enlarged and is filled with a complex partially fluid, partially solid, encapsulated structure. 3.0 x 2.4-2.8 cm. Inside the capsule, complex fluid is present as well as echogenic solid, tissue without evidence of blood flow on color Doppler. This solid appearing tissue is partially calcified.

BACKGROUND: The major factors individually reported to be associated with an increased frequency of CDKN2A mutations are increased number of patients with melanoma in a family, early age at melanoma diagnosis, and family members with multiple primary... expand abstract melanomas (MPM) or pancreatic cancer. METHODS: These four features were examined in 385 families with > or =3 patients with melanoma pooled by 17 GenoMEL groups, and these attributes were compared across continents. RESULTS: Overall, 39% of families had CDKN2A mutations ranging from 20% (32/162) in Australia to 45% (29/65) in North America to 57% (89/157) in Europe. All four features in each group, except pancreatic cancer in Australia (p = 0.38), individually showed significant associations with CDKN2A mutations, but the effects varied widely across continents. Multivariate examination also showed different predictors of mutation risk across continents. In Australian families, > or =2 patients with MPM, median age at melanoma ...

The principal focus of the research conducted by Professor Haywards group is on the molecular genetics of melanoma, a topic that he has significantly contributed to for more than 30 years. He is a foundation member of the International Melanoma Genetics Consortium (GenoMEL) and the Society for Melanoma Research (SMR). To further pursue work to better understand the genes underlying melanoma predisposition in the general population, as well as some rare families, Professor Hayward recently established two international consortia: the BAP1 Interest Group Consortium and the Uveal Melanoma Genome-wide Association Study Consortium. The groups other complementary key area of interest centres on applying a range of high throughput omics technologies to comprehensively characterize the genomic landscape of the various melanoma subtypes. To this end he is a principal investigator of the Australian Melanoma Genome Project, which seeks to characterize the genomic landscape of somatic mutations and ...

We have also identified different cellular compartment in these neural tumours caused by dedifferentiation. We are designing genetic tools to investigate, through lineage analyses, the cellular hierarchy governing tumour growth. We are using this new genetically tractable model to investigate the basic molecular principles governing the population of cancer stem cells. Our aim is to identify the conserved molecular pathways that need to be targeted for their elimination in order to cure cancer ...

Soucek, J; Sochman, J; Motycka, K; Novotna, O; and Slavik, K, The treatment of experimental mouse hemoblastosis. Iii. Chemotherapy of the lah vufb leukemia with some 4-amino analogues of floic acid. (1965). Subject Strain Bibliography 1965. 886 ...

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...

Cancers in the neural system presents a major health challenge. The most aggressive brain tumor in adults, glioblastoma, has a median survival of 15 months and few therapeutic options. High-risk neuroblastoma, a childhood tumor originating in the sympathetic nervous system, has a 5-year survival under 50%, despite extensive therapy. Molecular characterization of these tumors has had some, but so far limited, clinical impact. In neuroblastoma, patients with ALK mutated tumors can benefit from treatment with ALK inhibitors. In glioblastoma, molecular subgroups have not yet revealed any subgroup-specific gene dependencies due to tumor heterogeneity and plasticity. In this thesis, we identify novel treatment candidates for neuroblastoma and glioblastoma. In paper I, we discover novel drug targets for high-risk neuroblastoma by integrating patient data, large-scale pharmacogenomic profiles, and drug-protein interaction maps. Using a novel algorithm, TargetTranslator, we identify more than 80 targets ...

Soft Tissue Neoplasms. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.

Neuroblastoma is a very rare type of cancerous tumor that develops from nerve tissue. It usually occurs in infants and children.

Bone Tissue Neoplasms: Neoplasms composed of bony tissue, whether normal or of a soft tissue which has become ossified. The concept does not refer to neoplasms located in bones.

In this study, we demonstrate that PTEN is critical for the correct differentiation of PGCs to mature germ cells. Increased mitotic levels, higher percentages of apoptotic cells, and teratoma formation were observed in vivo for mutant male gonads (Figs 2, 3, 4). Moreover, in vitro experiments showed that the proliferative activities of PGCs and the efficiency of EG cell colony formation were enhanced by the loss of PEN function (Figs 6, 7).. Our observations indicate deregulated maintenance of PGCs in Pten-null male mice. Two main abnormalities were detected in Pten-null male gonads after E14.5, i.e. increased numbers of mitotic figures and higher apoptotic ratios (Figs 2, 3). One of the important roles of PTEN is to induce G1 arrest through the suppression of the PI3K/Akt pathway (Li and Sun, 1998; Ramaswamy et al., 1999; Sun et al., 1999). It seems reasonable that a significantly higher proportion of the Pten-null germ cells show mitotic figures. Although PTEN is known to cause apoptosis in ...

Fibrous Tissue Neoplasms: Neoplasms composed of fibrous tissue, the ordinary connective tissue of the body, made up largely of yellow or white fibers. The concept does not refer to neoplasms located in fibrous tissue.

Intracranial tumours are often described as benign or malignant, but these terms cannot be directly compared with their extracranial counterparts:. A benign intracranial tumour may have devastating effects if allowed to expand within the rigid confines of the skull cavity. A benign astrocytoma may infiltrate widely throughout brain tissue preventing complete removal, or may occupy a functionally critical site preventing even partial removal.. A malignant intracranial tumour implies rapid growth, poor differentiation, increased cellularity, mitosis, necrosis and vascular proliferation, but metastases to extracranial sites rarely occur.. ...

Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

1) Reducing the amount of food your stomach can hold by closing or removing parts of the stomach or. 2) By causing poor digestion of food by bypassing the stomach or part of the intestine. After surgery, patients usually lose weight quickly.. While some weight is often regained, many patients are successful in maintaining most of their weight. In some cases, surgery can lead to problems that require follow-up operations. Surgery can also reduce the number of vitamins and minerals in your body and cause gallstones.. If you are considering a weight loss program and have medical concerns, or are severely overweight, programs led by qualified health professionals may be best for you.. These professionals will likely monitor you for potential weight loss side effects and speak to your doctor if necessary.. Whether you decide to use weight loss programs on your own, or the non-clinical or clinical approach, a weight loss program should help you lose and maintain weight by teaching you healthy eating ...

Semantic Scholar extracted view of [Malignant soft tissue neoplasms. Problems with combined therapy. Radiologic diagnosis and radiotherapy]. by Hildegard Poppe

We also spoke with Jill to hear her experiences with Mens Health. Jills husband Neil was diagnosed with stage four testicular teratoma when he was just 23. Feeling fit, healthy and bulletproof they initially ignored the symptoms of Neils quick acting cancer.. He was told if hed left it a few more weeks it would have been too late. Perhaps if wed acted earlier he might have had 3-5 months treatment instead of 13 months treatment that he was extremely lucky to survive. The surgery would have been a lot less complicated.. After Neils treatment, Jill and Neil had two daughters, so its a very, very happy ending.. ...

Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the predictive value of a conventional phenotypic model. We analyzed 11 SNPs that were associated with melanoma risk in previous studies and were genotyped in MD Anderson Cancer Center (MDACC) and Harvard Medical School investigations. Participants with ≥15 risk alleles were 5-fold more likely to have melanoma compared to those carrying ≤6. Compared to a model using the most significant single variant rs12913832, the increase in predictive value for the model using a polygenic risk score (PRS) comprised of 11 SNPs was 0.07(95% CI, 0.05-0.07). The overall predictive value of the PRS together with conventional phenotypic factors in the MDACC population was 0.69 (95% CI, 0.64-0.69). PRS significantly improved the risk prediction and reclassification in melanoma as compared with ...

The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neopla …

Care guide for Stereotactic Gamma Ray Surgery For Benign Intracranial Tumors (Inpatient Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.

What is neuroblastoma? Neuroblastoma is a cancerous tumour that begins in nerve tissue of infants and very young children. The abnormal cells are often found in the nerve tissue that is present in the unborn baby and later develops into a detectable tumour. Neuroblastoma is rare in children older than 10 years of age, however, it does occur occasionally in adults. The tumour usually begins in the tissues of the adrenal gland found in the abdomen, but may also begin in nerve tissue in the neck, chest, and/or pelvis. The adrenal glands are positioned on top of the kidneys. These glands secrete hormones and other important substances that are required for normal functions in the body such as the nervous system. In Australia, approximately 60 children are diagnosed with neuroblastoma each year. It is often present at birth, but not detected until the tumour begins to grow and compress the surrounding organs. Most children affected by neuroblastoma have been diagnosed before the age of 5. In rare ...

If spinal vertebrae chafe or irritate nerve tissue, signals going from or to the affected organ or tissue can be excited. (i.e., diarrhea.). The nervous system is vulnerable where delicate nerve tissue comes into proximity with the moving bones of your spine. Thats why were interested in your spine!. ...

Neuroblastoma is a cancerous tumor. It grows in nerve tissue of babies and young children. The cancer cells grow in young nerve cells of a baby growing in the womb. These cells are called neuroblasts. Its is the most common cancer in babies under age 1. Its rare in children older than age 10.

Neuroblastoma is a cancerous tumor. It grows in nerve tissue of babies and young children. The cancer cells grow in young nerve cells of a baby growing in the womb. These cells are called neuroblasts. Its is the most common cancer in babies under age 1. Its rare in children older than age 10.

Neuroblastoma is a cancerous tumor. It grows in nerve tissue of babies and young children. The cancer cells grow in young nerve cells of a baby growing in the womb. These cells are called neuroblasts. Its is the most common cancer in babies under age 1. Its rare in children older than age 10.

Neuroblastoma is a cancerous tumor. It grows in nerve tissue of babies and young children. The cancer cells grow in young nerve cells of a baby growing in the womb. These cells are called neuroblasts. Its is the most common cancer in babies under age 1. Its rare in children older than age 10.

Our laboratory is working to develop mouse models of human disease. Experimental mice have been the major in vivo system used to investigate the molecular, cellular and genetic basis of health and disease for over 100 years.