TY - JOUR. T1 - Multiple primary cancers in patients with gastric cancer. AU - Wu, Chew Wun. AU - Lo, Su Shun. AU - Chen, Jen Hao. AU - Hsieh, Mao-Chih. AU - Li, Anna F.Y.. AU - Lui, Wing Yiu. PY - 2006/5/1. Y1 - 2006/5/1. N2 - Background/Aims: Some gastric cancer patients have multiple primary cancers (MPC). We evaluate the current status of MPC with gastric cancer. Methodology: 2,109 gastric cancer patients treated between 1987 and 2002 were analyzed. Results: There were 99 MPC with gastric cancer (4.7%). Second cancer (77.8%) was discovered within 5 years before and after the onset of gastric cancer. 34.3% of patients were discovered within 1 year (synchronous tumor). In the 77 male patients, prostate cancer was the most common occurrence (19.5%), followed by cancers of the colon (18.2%) and liver (14.3%). In the 22 female patients, colon cancer was the most common (31.9%) followed by breast and cervix cancers (22.7%). These cancers were the most common diseases in Taiwan in the same period. ...
Epidemiologic studies of various incidence patterns of multiple primary cancer in patients with cancer have guided research about carcinogenic mechanisms that may apply to several organ sites [1, 2]. At issue is whether risk patterns exist that predict subsequent primary cancer in patients with an index primary cancer of a particular organ and type. Also at issue is whether apparent increases in risk result from 1) shared or common etiologic factors in the pathogenesis of the index and second primary cases of cancer; 2) adverse toxic effects of agents used in the treatment of the index cancer; 3) random or chance effects [for example, those occurring after multiple significance testing]; or 4) spurious associations that are the result of confounding by correlated lifestyle risk factors or by biased ascertainment of new primary cancer as a result of more careful medical surveillance in patients with a history of cancer. The application of criteria for judging the biological plausibility of a ...
A 50 year old female admitted to R L jalappa Hospital, kolar, presented with synchronous primary tumours of the thyroid and breast. Pathological examination of a tissue sample following biopsy identified papillary carcinoma of the thyroid and invasive ductal carcinoma of the breast to provide a definitive diagnosis of synchronous primary tumors. The patient was healthy prior to diagnosis and the family history was non contributory. Upon admission, the size of the primary tumour biopsied, pathological diagnosis was an invasive carcinoma of the breast. A tumor measuring 3.0x2.5x2.0 cm was identified in the right side of the thyroid lobe, however, no further abnormalities were identified. Preoperative imaging included an ultrasound of the neck, which revealed a hypoechoic heterogeneity in the right lobe of the thyroid (size, 3.2x1.5 cm) exhibiting punc¬tate calcification. The patient was negative for clinical neck lymph node metastasis. A general physical examination did not indicate any ...
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Background: Due to improvements in diagnosis, the better outcomes of oncological patients and the increase in the average age, the incidence of synchronous tumours is likely to increase. Aim: To reflect on the challenges of a case with multiple integrated diagnostic and therapeutic approaches and to bring to consideration the increasing prevalence of similar situations. Case Presentation: In this clinical case, the authors describe the evolution of an asymptomatic patient with several synchronous tumours (a GEJ primary adenocarcinoma, a low grade urothelial carcinoma in situ, a localized squamous cell lung carcinoma and 2 IPMNs). Conclusion: The challenge of this case lies in the difficult diagnostic approach, the assembly of a multidisciplinary and time-sensitive treatment plan and the individualized follow-up, due to lack of guidelines. More research is needed in this area.
Multiple primaries [14] are more than one tumour arising in different sites and or of different histology either synchronous or metachronous depends on the duration between them, 2-month according to SEER data [15] and 6 months according to IARC. In our study, we used the definition of IARC. The burden of multiple tumours is expected to increase due to the use of accurate imaging techniques. In a single facility in Saudi Arabia, we collected 54 cases over 7 years. Multiple-Primary did not always signify a bad prognosis as we treated all non-metastatic cases with curative intent.. It is most imperative to diagnose it early before the patient reaches the metastatic stage. This means that we should have a high degree of suspicion. The role of the radiologist is crucial as usually, radiologists are first to flag for suspicion of multiple tumours. In our study, most of the synchronous tumours were detected initially by CT scan then confirmed pathologically. Examples from our study as CT scan done for ...
The last decade has experienced a steady increase in the incidence of MPM [16]. With the expected survival of oncology patients prolonged, it is no longer rare to observe a subsequent primary malignancy in long-term follow-up, especially those from therapy-related carcinogenesis [17, 18]. A recently published paper provided by the Surveillance, Epidemiology and End Results Program estimated 7.9% of cancer-survivors were living with a history of more than one primary malignancy in the U. S [16]. The reported prevalence estimated that cancer-survivors were at an increased risk of being diagnosed with a secondary primary malignancy [19-21]. Bhatia et al. showed the risk of second tumor was increased approximately 18 times in survivors of childhood Hodgkins lymphoma [21]. The incidence of second neoplasm in cancer-survivors (2.3%, 68/2909) of our center was in accordance with previous literature [6, 16, 22, 23], which was higher than that of the normal population [1]. We hypothesized that the ...
Five hundred and sixty-five cases of large bowel cancer were analysed. There were 8 (1.4%) appendiceal tumours, 296 (52.4%) colonic cancers, 236 (41.8%) rectal cancers, 6 (1.1%) anal cancers and 19 (3.4%) multiple primary cancers of the large bowel. Non-mucinous adenocarcinoma was by far the commonest histological type of large bowel cancer (74.7%). This was followed by mucinous carcinoma (20.7%). Other histological types were relatively uncommon. They included carcinoid tumours (1.8%), signet-ring cell carcinoma (1.5%), squamous cell carcinoma (0.7%), undifferentiated carcinoma (0.4%) and adenosquamous carcinoma (0.2%). The proportion of mucinous carcinoma was greater among the Indians and Malays than among the Chinese. There was a positive correlation between the grade and extent of spread of the tumour. The right colon had greater proportion of poorly differentiated adenocarcinomas than the left colon; this tendency was more evident in females. Mucinous carcinoma tended to occur more ...
In an international genetic study (International Sarcoma Kindred Study) reported in The Lancet Oncology, Ballinger et al found that approximately half of all patients with sarcoma harbored potentially pathogenic monogenic and polygenic variation in known and novel cancer genes.. Study Details. The study included 1,162 patients with sarcoma aged ≥ 15 years from 4 cohorts. Targeted exon sequencing using blood (n = 1,114) or saliva (n = 48) was performed for 72 genes selected on the basis of association with increased cancer risk. A case-control rare variant burden analysis included 6,545 white controls from 3 cohorts. Rare variants were classified as known, expected, or predicted.. Excess of Pathogenic Variants. Median age at cancer diagnosis was 46 years in the sarcoma probands. Multiple primary cancers were found in 170 patients (15%), and 155 (17%) of 911 families with informative pedigrees fitted recognizable cancer syndromes. On case-control rare variant burden analysis, 638 (55%) of the ...
Synchronous primary cancers are occasionally observed, but TTM is extremely rare; only about 100 cases have been reported in the English literature. Campbell et al. [7] proposed the concept of TTM, which can be distinguished from collision tumor based on following criteria: 1) more than one primary tumor; 2) the recipient tumor may be a true benign or malignant neoplasm; 3) the metastatic neoplasm is a true metastasis with established growth within the host tumor, not the result of contiguous growth (collision tumor) or tumor emboli; 4) primary tumors spreading into the lymphatic system in the setting of generalized lymphoreticular malignancy are excluded.. According to the seed and soil hypothesis [8] of cancer metastasis, interactions between cancer cells (seed) and specific organ microenvironments (soil) determine the outcome of metastasis. Renal cell carcinoma and meningioma are both highly vascularized tumors, and have high lipid and glycogen content, which can provide a fertile ...
A subtype of familial breast cancer that includes colorectal cancer was recognized by Lynch et al. already in 1972 [19] and recently the CHEK2 1100delC mutation was proposed to represent a low-penetrant breast cancer susceptibility allele [10, 11]. This variant has been identified at a particularly high frequency (18%) in families with a hereditary breast- and colorectal cancer phenotype [16]. Since development of multiple primary tumors is a hallmark of hereditary cancer and a high frequency of the CHEK2 1100delC had been described in hereditary breast and colorectal families, we assessed the contribution of this variant to the development of double primary breast and colorectal cancer in a population-based patient material. Among the 75 patients with metachronous tumors of the breast and the colorectum successfully studied, 2 (2.5%) carried the CHEK2 1100delC mutation compared to 1% in the control group [18]. These frequencies were not significantly different (p = 0.26), but the small size of ...
Synchronous composite tumors have been described but are uncommon. Moreover, simultaneous occurrence of synchronous tumors in the same tissue or organ is even less common. We report a case of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma and malignant melanoma (MM) occurring synchronously in the same lymph node. Several cases of an association between cutaneous malignancies and lymphoproliferative disorders have been reported. Some of which included CLL and MM, occurring in the same patient often CLL after MM. The risk of having CLL after MM has been reported to be increased. Various genetic and environmental etiologies have been postulated, but have as yet not been proven. To our knowledge this is the first time that synchronous occurrence of these two malignant processes in the same tissue is described. In this case it is important that the melanoma was recognized in the excised lymph node, as this finding had much more critical treatment and long term survival consequences.
Di Martino E, Sellhaus B, Hausmann R, Minkenberg R, Lohmann M, Esthofen MW.//. Patients who developed metachronous tumours had a five-year survival rate of 68.9 per cent for the index tumours, and a 26 per cent five-year survival rate with the occurrence of a second neoplasm. With synchronous tumours a mean survival time of 18 months and a five-year survival rate of 11.9 per cent was found (p , 0.0001).. The prognosis of synchronous tumours is significantly lower when compared to malignancies of a metachronous nature, despite some encouraging individual results. Only the early implementation of aggressive treatment methods for second primaries is successful in terms of survival.. ...
Ileal neuroendocrine tumors (NETs) represent the most common neoplasm of the small intestine. Although up to 50% of patients with ileal NETs are diagnosed with multifocal disease, the mechanisms by which multifocal ileal NETs arise are not yet understood. In this study, we analyzed genome-wide sequencing data to examine patterns of copy number variation in 40 synchronous primary ileal NETs derived from three patients. Chromosome (chr) 18 loss of heterozygosity (LOH) was the most frequent copy number alteration identified; however, not all primary tumors from the same patient had evidence of this LOH. Our data revealed three distinct patterns of chr18 allelic loss, indicating that primary tumors from the same patient can present different LOH patterns including retention of either parental allele. In conclusion, our results are consistent with the model that multifocal ileal NETs originate independently. In addition, they suggest that there is no specific germline allele on chr18 that is the ...
Oral squamous cell carcinoma (OSCC) is an aggressive epithelial malignancy that is the sixth most common neoplasm in the world today. Despite numerous advances in treatment the long-term survival has remained ~55%. This poor long-term survival is due to a number of factors including delayed diagnosis and the development of multiple primary tumors. Therefore, the early detection and prevention of all premalignant lesions is critical for the long-term survival of these patients ...
Researchers have packaged a widely used cancer drug into nanoparticles, more than doubling its effectiveness at destroying tumors. They found significantly
Semantic Scholar extracted view of Squamous cell carcinoma of the liver: metastasis or primary neoplasm? by Silvia Bondini et al.
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A Case Report Describing a Rare Presentation of Simultaneous Occurrence of MPO-ANCA-Associated Vasculitis and Rheumatoid Arthritis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Lung cancer is the second most common non-skin malignancy. In a PET-CT-based staging of lung cancer, positive metabolic neck avidity may be considered a metastasis; however, other interpretations may be synchronous tumor or non-malignant avidity. We present nine cases of synchronous lung and thyroid cancer, which do not share common characteristics, and whose concurrent detection affects the patients treatment and prognosis. ...
Although some epidemiologic associations for ovarian cancer are established, such as the risk reduction due to parity or oral contraceptive use, the influence of other characteristics like endometriosis and non-steroidal anti-inflammatory use is less clear. Distinguishing categories of ovarian cancer based on shared pathways of development may clarify these associations and further our understanding of the disease. Traditionally, ovarian cancers have been thought to arise from the ovarian surface epithelium. Recent evidence in BRCA1 or 2 mutation carriers showing synchronous tumors in fallopian tubes and potential precursor lesions with p53 signatures that match tumors suggest that some "ovarian" cancers may originate in the fallopian tube. Tumor origin (e.g., ovarian vs. fallopian) may be classified by rigorous pathologic review protocol, including the identification of tubal lesions and p53 signatures, but this is not practical in population-based studies where the needed tissue is not always ...
Development of resistance is a significant clinical problem for virtually all targeted cancer therapies. We have generated a reproducible, patient derived xenograft (PDX) model of acquired vemurafenib resistance to address these challenges. Continuous treatment of V600E melanoma tumors, caused synchronous tumor stasis for approximately 7 weeks, following which, all tumors displayed simultaneous resistance marked by rapid tumor growth. Additionally, this model maintains the resistance phenotype upon serial transplantation, providing a platform for testing rational drug selection. The fidelity of the PDX models was further confirmed using a BRAF V600V tumor which did not respond to vemurafenib. Onset of vemurafenib resistance is accompanied by increased phosphor-ERK signifying re-engagement of the MAPK signaling pathway and supporting MEK as a potential target. MEK inhibition in vemurafenib resistant tumors using PD0325901, resulted in rapid tumor shrinkage and dramatically reduced phosphor-ERK ...
Background - Endoscopic mucosal resection is one of the most frequent therapeutic alternatives for large colorectal lateral spreading tumors. There are few data on the prevalence of synchronous lesions on these patients. Objective - To describe the prevalence of synchronous colorectal lesions in patients referred for endoscopic mucosal resection of lateral spreading tumors ,20 mm.m.br/wp-admin/post-new.php?classic-editor&post_type=post&source_lang=pt-br&trid=2894&lang=en&admin_bar=1…. ...
Treatment of the primary neoplasm with radiotherapy or chemotherapy is an established risk factor for second neoplasms (SNs) after childhood cancer. As only a small percentage of the treated children suffer from SN, other shared risk factors must be involved. A predisposition for the occurrence of a SN might be a pre-existing somatic genetic defect associated with DNA repair. We investigated the association between gene expression involved in DNA-repair and the development of SNs after childhood cancer. Designed as a feasibility study this project addressed the possibility of obtaining samples for genetic analyses from former patients through the German Childhood Cancer Registry. We recruited 20 patients with two neoplasms (the first occurring in childhood) and 20 matched patients with one neoplasm in childhood. Matching was by first neoplasm, age and year of first diagnosis. Registered SN were confirmed to be no relapses or alternative manifestations of the primary neoplasm. Participants were ...
Brave Tia has suffered a double cancer diagnosis in less than six months - mast cell tumour and lymphoma and is now coping with chemotherapy. Well done Tia.
In cognitive radio networks, the licensed frequency bands of the primary users (PUs) are available to the secondary user (SU) provided that they do not cau
Twenty-three patients (16 male, 7 female), age 67 years (28-80) were operated for 6.5 (1-38) metastases of which the largest was 40 mm (14-130). Six (27.3%) patients had extra-hepatic metastases, 16 (72.7%) synchronous presentation. All patients received chemotherapy, 6 cycles (3-25) preoperatively and 16 (70%) postoperatively. Ten patients (43%) were rescue ALPPS after failed PVO. Severe complications occurred in 13.6% and one (4.5%) patient died within 90 days of surgery. After a median follow-up of 22.5 months from surgery and 33.5 months from diagnosis of liver metastases estimated 2 year overall survival was 59% (from surgery) and 73% (from diagnosis). Liver only recurrences (n = 8), were treated with reresection/ablation (n = 7) while lung recurrences were treated with chemotherapy ...
Assign 9863 for CML in 2008. The 2010 diagnosis is the same histology. Per the Hematopoietic database, chronic and accelerated phase are alternate names. This is the same primary per Rule M2. Blast phase (crisis) is also an alternate name for CML, which makes the 2012 diagnosis the same primary per Rule M2. As you noted, not all histologies have transformations. If a transformation is not listed, rules M8-M13 do not apply. For these types of cases, use M15 and use the multiple primaries calculator. ...
Rat IgG (H&L), 0.1 mg. This secondary antibody is specifically designed for the detection of multiple primary antibodies (polyclonal or monoclonal) of different host species in experiments where cells are simultaneously labeled without unwanted cross
Rabbit IgG (H&L), 0.2 mg. This secondary antibody is specifically designed for the detection of multiple primary antibodies (polyclonal or monoclonal) of different host species in experiments where cells are simultaneously labeled without unwanted cross
J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20 ...
Introduction. Renal cell carcinoma is one of the top 10 most common cancers in United States and its incidence has been on the rise since the 1990s with an estimated 63,000 new cases in 2016. Other urogenital malignancies, such as penile cancer, are less common in the United States with an annual incidence of 2000 cases.1 Synchronous primary malignancies of the urogenital tract have become increasingly recognized though they are only found as case reports. We describe a patient who initially presented with a large left inguinal mass, and through a series of diagnostic imaging and biopsies, he was found to have 2 separate primary malignancies: right clear cell renal cell carcinoma (RCC) and penile squamous cell carcinoma (PSCC) with metastasis to the left inguinal lymph node. We hope to raise awareness of multiple synchronous primary tumors when present with a urogenital malignancy, diagnostic modalities, and the challenge to treatment.. Case. An 86-year-old male, who had not seen a physician for ...
TP53Z : Li-Fraumeni syndrome (LFS) is a rare autosomal dominant hereditary cancer syndrome associated with germline mutations in the TP53 (also p53) gene. LFS is predominantly characterized by sarcoma (osteogenic, chrondrosarcoma, rhabdomyosarcoma), young-onset breast cancer, brain cancer (glioblastoma), hematopoietic malignancies, and adrenocortical carcinoma in affected individuals. LFS is highly penetrant; the risk for developing an invasive cancer is 50% by age 30 and 90% by age 70 with many individuals developing multiple primary cancers. Childhood cancers are also frequently observed and typically include soft-tissue sarcomas, adrenocortical tumors, and brain cancer. Other reported malignancies include melanoma, Wilms tumor, kidney tumors, gonadal germ cell tumor, pancreatic cancer, gastric cancer, choroid plexus cancer, colorectal cancer, prostate cancer, endometrial cancer, esophageal cancer, lung cancer, ovarian cancer, and thyroid cancer.   There are published criteria for the use in
Actinic keratosis (AK) affects millions of people worldwide, and its prevalence continues to increase. AK lesions are caused by chronic ultraviolet radiation exposure, and the presence of two or more AK lesions along with photodamage should raise the consideration of a diagnosis of field cancerization. Effective treatment of individual lesions as well as field cancerization is essential for good long-term outcomes. The Swiss Registry of Actinic Keratosis Treatment (REAKT) Working Group has developed clinical practice guidelines for the treatment of field cancerization in patients who present with AK. These guidelines are intended to serve as a resource for physicians as to the most appropriate treatment and management of AK and field cancerization based on current evidence and the combined practical experience of the authors. Treatment of AK and field cancerization should be driven by consideration of relevant patient, disease, and treatment factors, and appropriate treatment decisions will ...
TY - JOUR. T1 - A case report of multiple primary prostate tumors with differential drug sensitivity. AU - Wilkinson, Scott. AU - Harmon, Stephanie A.. AU - Terrigino, Nicholas T.. AU - Karzai, Fatima. AU - Pinto, Peter A.. AU - Madan, Ravi A.. AU - VanderWeele, David J.. AU - Lake, Ross. AU - Atway, Rayann. AU - Bright, John R.. AU - Carrabba, Nicole V.. AU - Trostel, Shana Y.. AU - Lis, Rosina T.. AU - Chun, Guinevere. AU - Gulley, James L.. AU - Merino, Maria J.. AU - Choyke, Peter L.. AU - Ye, Huihui. AU - Dahut, William L.. AU - Turkbey, Baris. AU - Sowalsky, Adam G.. PY - 2020/12/1. Y1 - 2020/12/1. N2 - Localized prostate cancers are genetically variable and frequently multifocal, comprising spatially distinct regions with multiple independently-evolving clones. To date there is no understanding of whether this variability can influence management decisions for patients with prostate tumors. Here, we present a single case from a clinical trial of neoadjuvant intense androgen deprivation ...
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UCLA scientists have developed a NanoVelcro Chip that can detect and isolate single cancer cells from patient blood samples for analysis.. Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.. Circulating tumor cells, or CTCs, play a crucial role in cancer metastasis, spreading from tumors to other parts of the body, where they form new tumors. When these cells are isolated from the blood early on, they can provide doctors with critical information about the type of cancer a patient has, the characteristics of the individual cancer and the potential progression of the disease. Doctors can also tell from these cells how to tailor a personalized treatment to a specific patient.. In ...
Relay For Life is an amazing sight of colour, excitement and passion as thousands of people, take on the challenge of keeping their teams baton, and symbol of hope, moving around the track for 19 hours.. Mr Petersen began his Relay journey as a volunteer in 2004 after his best friend and Gramps ultimately lost his cancer battle.. His passion to continue his Grandfathers fight encouraged him to move into the volunteer Entertainment Coordinator role after starting as main stage MC.. After getting a taste of the magic that is Relay, Andrew decided to leave his job and apply for a full time role at Cancer Council SA.. The Project Officer role works closely with local communities to empower them to run their own Relay For Life events.. "I do it for Gramps and the whole cancer community," Andrew said.. "Gramps was a double cancer survivor, prostate and lymphoma. It was very hard for him and Nanna but he soldiered on like a trooper.". Andrew explains the fire he has for working towards the common ...
Historical Staging and Coding Manuals. Appendix C brings together the site-specific instructions needed to abstract a case, facilitating efficiency and accuracy. The site-specific coding modules include SEER Coding Guidelines; Equivalent Terms, Definitions, Tables, Charts and Illustrations; Multiple Primary Rules; Histology Coding Rules; Collaborative Stage Coding Instructions1 and Surgery of Primary Site codes2.. General instructions in the main manual are applicable in the absence of site-specific instructions. All modules include the collaborative stage and surgery codes, and multiple primary and histology coding rules. Some modules include site-specific coding guidelines. The goal is to have stand-alone modules for major anatomic sites.. ...
Background This study evaluates the surgical morbidity and long-term outcome of colorectal cancer surgery within an unselected band of patients treated over the time 1994C2003. of HNPCC (1%). Merging all tumours, there have been 186 malignancies (20.6%) thought as UICC stage I, 235 (26.1%) stage II, 270 (29.9%) stage III and 187 (20.6%) stage IV situations. Twenty-four (2.7%) situations were of undetermined stage. Postoperative problems happened in 38% of the full total group (37.8% of CC cases, 37.2% from the RC group, 66.7% from the synchronous cancer sufferers and 50% of these with HNPCC, p = 0.19) Mortality rate was 0.8%, (1.3% CORO1A for cancer of the colon, 0% for rectal malignancy; p = 0.023). Multivisceral resection was performed in 14.3% of cases. Disease-free success in situations resected for treatment was 73% at 5-years and 72% at 8 years. The 5- and 8-calendar year overall survival prices had been 71% and 61% respectively (total situations). At 5-calendar Ketanserin (Vulketan Gel) ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011 ...
This document describes, among other things, systems and methods for characterizing a tachyarrhythmia. A method comprises obtaining a current first primary characterization of the tachyarrhythmia and a current first primary confidence level of the current first primary characterization, obtaining a current second primary characterization of the tachyarrhythmia and a current second primary confidence level of the current second primary characterization, and determining a current secondary characterization using the current first primary characterization, the current first primary confidence level, the current second primary characterization, and the current second primary confidence level.
Our study does not support that the inferior prognosis in SBBC patients is due to having more aggressive tumours per se, but rather the combined effect of having two simultaneous cancers.
I had sequenced the N terminus of gp96 from two antigenically distinct tumors, and the sequences were the same. I had generated a polyclonal rabbit serum against the protein in a rabbit called ADAM, and the antiserum detected an identical-sized protein in all tumors and every tissue. In spite of this uniformity, the protein from each tumor elicited immunity only against the tumor from which it was isolated. Gp96 from normal tissues did not elicit tumor immunity against any tumor tested. These findings exhilarated me. I thought that I may have identified a polymorphic gene, perhaps like the MHC or the immunoglobulin family, which was rearranged in tumors and might be responsible for the individually distinct antigenicity of chemically induced mouse sarcomas. After extensive efforts at cloning and sequencing the gp96 cDNA (with the help of Yao-Tseng Chen) (7), and doing intensive Southern blots of genomic DNA from normal tissues and many tumors, there was no hint of polymorphisms or ...
Background The purpose of this study was to present the clinicopathological features of a series of patients with human papillomavirus (HPV)-associated head and neck second primary tumors. Methods Patients with HPV-associated head and neck second primary tumors from 3 centers were identified. HPV infection was evaluated using p16 by immunohistochemistry (IHC), high-risk HPV DNA by in situ hybridization (ISH), and HPV genotyping by DNA polymerase chain reaction (PCR) enzyme immunoassay (EIA). Results Eleven patients were identified: 5 with synchronous and 6 with metachronous HPV-positive second primary tumors, the latter demonstrating a mean time interval of 5 years. There were 13 second primary tumors: 11 oropharyngeal, 1 nasopharyngeal, and 1 floor of the mouth. Nine of 10 genotyped patients harbored HPV-16, and 1 patient had HPV-33 in 3 synchronous tumors. Conclusion HPV-associated second primary tumors may present as synchronous and/or metachronous lesions and can arise outside the oropharynx ...
Background: Collision Tumours of the thyroid are a rare pathology that present a diagnostic and treatment challenge. Here we present an interesting case and a review of the current literature as to inform management. Methods and Results: An 88 year o
Background Because most patients with small-sized non-small cell lung cancer (NSCLC) are asymptomatic, their lesions are detected by cancer screenings or routine checkups for other diseases....
Adult; Aged; Breast Neoplasms; Case-Control Studies; Denmark; Female; Humans; Lung Neoplasms; Middle Aged; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Risk ...
Johnson and Johnson will partner with Massachusetts General Hospital to develop and market a blood test that could find a single cancer cell circulating in a persons blood, the company said Monday.
Background: We conducted a systematic review and meta-analysis of existing data from observational studies to assess the strength of the association of alcohol drinking with second primary cancer risk in patients with upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) cancer.. Methods: PubMed and Embase were searched up to July 2012 and the reference lists of studies included in the analysis were examined. Random-effects models were used to estimate summary relative risks (RR) and 95% confidence interval (CI).. Results: Nineteen studies, 8 cohort and 11 case-control studies, were included. In highest versus lowest meta-analyses, alcohol drinking was associated with significantly increased risk of UADT second primary cancers (RR, 2.97; 95% CI, 1.96-4.50). Significantly increased risks were also observed for UADT and lung combined (RR, 1.90; 95% CI, 1.16-3.11) and all sites (RR, 1.60; 95% CI, 1.22-2.10) second primary cancers. For an increase in the alcohol intake of 10 ...