Fogh, J; Fogh, J M.; and Orfeo, T, "Tumor production in nude mice by cultured human tumor cell lines. Abstr." (1977). Subject Strain Bibliography 1977. 2541 ...
Looking for carcinomas, carcinomata? Find out information about carcinomas, carcinomata. see neoplasm neoplasm or tumor, tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to... Explanation of carcinomas, carcinomata
Rosenstein, M M.; Pelus, L M.; and Strausser, H R., "Host-mediated immune suppression in tumor bearing mice. In vitro reversal by indomethacin or removal of adherent cells. Abstr." (1978). Subject Strain Bibliography 1978. 375 ...
Abstract. Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. While former studies have indicated that T-cell dependent processes mediate CR in hosts bearing immunogenic small tumors, the most universal manifestation of CR induced by immunogenic and non-immunogenic large tumors had been associated with an antitumor serum factor that remained an enigma for many years. In a recent paper, we identified that elusive factor(s) as an equi-molar mixture of meta-tyrosine and ortho-tyrosine, two isomers of tyrosine that are not present in normal proteins and that proved to be responsible for 90% and 10%, respectively, of the total serum anti-tumor activity. In this work, we have extended our previous findings demonstrating that a periodic intravenous administration of meta-tyrosine induced a dramatic reduction of lung and hepatic metastases generated in mice bearing two different metastatic murine tumors ...
In the present study, a multivariable analysis of the CD8+ T-cell response in mice vaccinated with different recombinant vaccines encoding the melanoma antigen TRP-2 delineated three main situations. The simplest finding involved the activity of the powerful rAd-hTRP-2 vaccine in prophylaxis of tumor challenge. All of the mice mounted a vigorous immune response against the mouse Kb-restricted epitope, as indicated by the significant changes in the number and functions of TRP-2-specific T lymphocytes. The immune response was so strong that correlation with the number of metastases was not feasible because the majority of the mice did not present countable metastases after challenge with B16 (7 of 10 mice had no metastases). T lymphocytes stimulated with the TRP-2180-188 peptide in vitro also recognized the wild-type melanoma. Nevertheless, it must be noted that prophylactic vaccination with the xenogeneic form of the antigen, although valuable for several experimental mouse tumor antigens, would ...
Ethris proprietary Stabilized Non-Immunogenic mRNA (SNIM® RNA) platform includes a toolbox of technologies to generate mRNA molecules that are stable, result in production in the patients own body of therapeutic proteins, and which escape recognition by the bodys immune system. These mRNA technologies paired with Ethris proprietary delivery systems for organ- and cell- targeted delivery of mRNA has generated a pipeline of Transcript Therapies, which Ethris is developing to treat serious diseases ...
A competent and expanding vascular supply is a necessary component of the progressive growth of solid tumors because cells in solid tumors, like normal tissue, must receive oxygen and other nutrients to survive and grow (17) . The connection between oxygen supply and tumor growth was first made in the 1950s by radiobiologists who were aware of oxygen as a radiosensitizer and the fact that hypoxic cells in tumors are resistant to radiation therapy (18) . Histological analyses of human and rodent tumors performed by Thomlinson and Gray (18) were the first studies to suggest that regions of viable cells exist close to tumor blood vessels and that these walls or cords of viable tumor cells correspond in thickness to the distance that oxygen can diffuse (1-2 mm3). The "tumor cord" model implied that hypoxic cells exist in a state of oxygen and nutrient starvation at the limits of the diffusion range of oxygen, and it was hypothesized that tumor cells could proliferate and grow only if they were close ...
May be imported without a USDA permit.. In addition, monoclonal antibodies intended for in vivo human use do not require a permit.. However, (1) cell lines derived from livestock or avian species, (2) cell lines derived from any species which will be used for in vivo use, and (3) cell lines of any species which may have been exposed to exotic livestock or avian disease agents will require a USDA, VS import permit.. Procedures:. A USDA, VS import permit will NOT be required for cell lines other products of cell lines, including monoclonal antibodies if the shipment is accompanied by:. ...
J:113221 Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P, Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis. Cancer Immun. 2006;6:10 ...
Patients think experimental cancer drugs will work for them, even though fewer than 5 percent ever benefit from early-phase studies.
PDT in tumor-bearing mice. (a) 4T1 cells were injected subcutaneously in two separate locations on the back of BALB/c mice. After tumors were established (marke
MTB has been designed to aid researchers in such areas as choosing experimental models, reviewing patterns of mutations in specific cancers, and identifying genes that are commonly mutated across a spectrum of cancers.
|p|SL-327 is a selective inhibitor of MEK1 and MEK2 with IC50 values of 0.18 and 0.22μM,  respectively.|br /|MEK1 and MEK2 (ERK) are a kinase enzyme which phosphorylate mitogen-activated protein kinase (MAPK). Extracellular signal-regulated kinase
In this issue of Clinical Cancer Research, a new development in adoptive T-cell therapy experimental mouse tumor model is reported by Leisegang and colleagues (1).. In retrospect, the 1990s were considered a golden period for tumor immunology when many tumor antigens recognized by T cells were identified. The antigens reported by Boon and colleagues in both murine and human cancers (2, 3) were derived from genes that are overexpressed in cancer and fetal tissues (4). The second class of unmutated antigens recognized by tumor-reactive T cells is tissue-specific antigens that are also found in tumor cells (5). These unmutated tumor antigens were favored for cancer vaccines and cancer therapy because they are present in a high proportion of human cancers. However, the classical study by Prehn and Main (6) has cast a long shadow on the utility of the shared tumor antigen, as their in vivo analysis showed that tumor rejection antigens are by and large individually specific. In supporting this notion, ...
CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8+ T cell-dependent manner. DNAM-1/CD226, Batf3, IL12p35, and IFNγ were also critical, and CD96-deficient CD8+ T cells promoted greater tumor control than CD96-sufficient CD8+ T cells. The antitumor activity of anti-CD96 therapy was independent of Fc-mediated effector function and was more effective in dual combination with blockade of a number of immune checkpoints, including PD-1, PD-L1, TIGIT, and CTLA-4. We consistently observed coexpression of PD-1 with CD96 on CD8+ T lymphocytes in tumor-infiltrating leukocytes both in mouse and human cancers using mRNA analysis, flow cytometry, and multiplex IHF. The combination of anti-CD96 with anti-PD-1 increased the percentage of IFNγ-expressing CD8+ T lymphocytes. Addition of anti-CD96 to anti-PD-1 and anti-TIGIT ...
The time- and dose-dependent effects of recombinant human interleukin 1α (IL-1α) on the antitumor activity of mitomycin C (MMC) and porfiromycin (PORF) were studied in RIF-1 and Panc02 solid tumor model systems. IL-1α produced dose-dependent sensitization of clonogenic RIF-1 tumor cells to MMC in vivo. IL-1α chemosensitization was highly schedule dependent, and the most efficacious schedules produced dose-modifying factors of 3.6 and 5.1 for MMC and PORF, respectively. More than additive clonogenic cell kill after IL-1α-chemotherapy combinations reflected increased cellular sensitivity to MMC and PORF. The combinations also produced marked decreases in the yield of viable tumor cells, suggesting that the bioreductive drugs may have also potentiated the microvascular injury and ischemia produced by IL-1α. Dexamethasone inhibited and ketoconazole, an inhibitor of corticosterone biosynthesis, enhanced IL-1α-mediated chemosensitization in these models. IL-1α mediated chemosensitization to ...
Inoculation of mice from appropriate crosses with two strain A tumours and one dba (subline 2) tumour showed close linkage of such a gene with the locus for fused. With the A strain it was shown that the gene was identical with that for antigen II present in the erythrocytes. The gene is therefore labelled $H_{2}$. Of sixty-nine backcross mice tested, both serologically and by tumour inoculation, sixty-five gave concordant results, four discordant results. In general, it appears that serological tests are preferable to tumour inoculation in the identification of genotypes. On serological grounds it is suggested that the dba gene is an allele of the above and should be called $H_{2}{}^{d}$. It is possible that there is a long series of alleles at this locus. The indicated genotype of the strains used is as follows: $A,H_{2}H_{2}$; $dba,H_{2}{}^{d}H_{2}{}^{d}$; CBA, C57 and $P,h_{2}h_{2}$; $CA,Fu$ $h_{2}/fu$ $h_{2}$. Further tests may show differences in the $h_{2}$ allele in the last four ...
Consistent with previous observations, c-Met Inhibitors staining exposed substantial regions of hemorrhagic necrosis devoid of CD31 staining along with viable tumor cells and CD31 blood vessels in the tumor rim. Interestingly, CD31 immunostained sections of orthotopic MCA tumors showed a really selective vascular response to DMXAA with intact vasculature noticeable in the neighboring muscle tissue.. Evaluation of R1 values of muscle tissue had been consistent with this observation and showed no statistically important big difference amongst handle and treatment method groups. Ultimately, we determined if the differential vascular response to DMXAA among ectopic and orthotopic MCA tumors correlated with intratumoral levels of TNF, a principal cytokine concerned in antivascular activity of DMXAA. Differences in intratumoral VEGF ranges have been also analyzed. As proven in Fig. 5A, untreated handle MCA tumors established at ectopic and orthotopic tissue sites showed very reduced amounts of TNF, ...
iframe src="https://biblio.ugent.be/organization/GE17?embed=1&hide_pagination=1&hide_info=1&hide_options=1&hide_cluster=1" ...
iframe src="https://biblio.ugent.be/organization/GE17?embed=1&hide_pagination=1&hide_info=1&hide_options=1&hide_cluster=1" ...
The 1% are very different from you and me.. But they dont just eat, dress, and act differently…. They treat cancer differently too.. And heres the incredible part…. They DONT shell out hundreds of thousands for experimental cancer therapies.. They DONT visit overpriced hospitals, where theyre injected with radiation or poison.. And they DONT experience deadly side effects or die within 12 months from ineffective chemo.. Instead they apply a little-known cancer protocol - a safeguarded health secret in elite …. ...
Interleukin (IL)-21 is a recently discovered cytokine in early clinical development, which has shown anti-tumor activity in various animal models. In the present study, we examine the anti-tumor activ
China Dts-3 Three Phase Electrical Enrgy Meter Instruments, Find details about China Kwh Meter, Energy Meter from Dts-3 Three Phase Electrical Enrgy Meter Instruments - Yueqing Tainihan Electrical Technology Co., Ltd.
Consistent with previous observations, c-Met Inhibitors staining exposed substantial regions of hemorrhagic necrosis devoid of CD31 staining along with viable tumor cells and CD31 blood vessels in the tumor rim. Interestingly, CD31 immunostained sections of orthotopic MCA tumors showed a really selective vascular response to DMXAA with intact vasculature noticeable in the neighboring muscle tissue.. Evaluation of R1 values of muscle tissue had been consistent with this observation and showed no statistically important big difference amongst handle and treatment method groups. Ultimately, we determined if the differential vascular response to DMXAA among ectopic and orthotopic MCA tumors correlated with intratumoral levels of TNF, a principal cytokine concerned in antivascular activity of DMXAA. Differences in intratumoral VEGF ranges have been also analyzed. As proven in Fig. 5A, untreated handle MCA tumors established at ectopic and orthotopic tissue sites showed very reduced amounts of TNF, ...
Health,...They target malignancies of the cervix prostate and breast among oth...TUESDAY April 15 (HealthDay News) -- A germ that commonly causes food...A new trial shows that a live Listeria vaccine called Lovaxin C is saf...Listeria is a common bacteria found on leafy vegetables and dairy prod...,Experimental,Cancer,Vaccines,Show,Promise,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Tetrabromoethane (TBE) is a halogenated hydrocarbon, chemical formula C2H2Br4. Although three bromine atoms may bind to one of the carbon atoms creating 1,1,1,2-tetrabromoethane this is not thermodynamically favorable, so in practice tetrabromoethane is equal to 1,1,2,2-tetrabromoethane, where each carbon atom binds two bromine atoms. It has an unusually high density for an organic compound, near 3 g/mL, due largely to the four bromine atoms ...
Despite early reports that brain surgery would not be an option for Senator Edward Kennedy, the lawmaker is recovering after a successful operation, which was carried out at Duke University Medical Center today. The delicate procedure was performed by Allan Friedman, a highly-respected neurosurgeon, and will be followed by focused radiation and chemotherapy. Since none \[…\]
A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-aminoacetamidoxime hydrochloride, were also active against P388 leukemia. Acetamidoxime was marginally active against Lewis lung carcinoma. The active amidoximes showed best activity against L1210 leukemia when given two times daily, 5 hours apart, for 8 days. Most of the amidoximes produced excessive central nervous system stimulation.
NSCLC tumors are appropriate targets for active immunotherapy, because they are non-immunogenic, which indicates that NSCLC does not stimulate a spontan
|p||strong|Technical Advantage: |/strong| This formulation in not available from other suppliers|br /| McCoys 5A medium was originally formulated to meet the culture requirements of Novikoff Hepatoma cells, and has been found to support the indefinite proliferation of Walker256 carcinoma cells along with a wide range of human and rat normal and transformed cells.  Originally modified by Iwakata and Grace, this version of McCoys 5A includes increased levels of inositol and glucose, and contains L-glutamine and 25 mM HEPES.|br /| -  Complete Certificate of Analysis available for each production lot, along with full formulation information|br /| -  Produced under the highest industry standards to ensure superior results|/p|
In the last chapter, characteristics and mechanisms of the early stages of neoplastic develop- ment-initiation and promotion-were presented as being the result of cellular and molecular changes induced by specific ...
Circulating Tumor Cells (CTCs) have been extensively explored as circulating biomarkers in various cancers. Due to their rarity, heterogeneity and stem cell-like properties, detecting and pro
Here we describe a method to separate and enrich components of the tumor immune and non-immune microenvironment in established...
Identify the cell parts using the clues provided. 1. THORCSPALLO 2. LEEREACNMBML 3. OUVLEAC 4. LCOSNUULE 5. BDOGLYIOG 6. ORMCIATNH Im needed for food. Im the outside of an animal cell. You name it - I can store it! I make ribosomes. I work with the ER. Im full of genetic information.
Who We Are The Experimental Cancer Treatment Unit (ECRU) was set up with the purpose of academically enhancing support for early phase clinical trials. Its focus is on providing a single point of engagement for the conduct of Phase 0/1/2 trials. The unit is part of the Department of Medical Oncology and was initiated in 2009. The core team collaborates closely with other clinicians and scientists committed to preclinical and clinical development of new anticancer drugs. Our core interests cover all solid tumours and lymphomas. At ECRU, we coordinate the aspects of modern drug development from target discovery and validation, xenograft drug screening, clinical pharmacology and biomarker correlative clinical trials. This includes the ability to do sequential tumor biopsies for biomarker development in certain trials. Mission of ECRU: ...
Who We Are The Experimental Cancer Treatment Unit (ECRU) was set up with the purpose of academically enhancing support for early phase clinical trials. Its focus is on providing a single point of engagement for the conduct of Phase 0/1/2 trials. The unit is part of the Department of Medical Oncology and was initiated in 2009. The core team collaborates closely with other clinicians and scientists committed to preclinical and clinical development of new anticancer drugs. Our core interests cover all solid tumours and lymphomas. At ECRU, we coordinate the aspects of modern drug development from target discovery and validation, xenograft drug screening, clinical pharmacology and biomarker correlative clinical trials. This includes the ability to do sequential tumor biopsies for biomarker development in certain trials. Mission of ECRU: ...
Angiogenesis is a hallmark of malignant neoplasias, as the formation of new blood vessels is required for tumors to acquire oxygen and nutrients essential for their continued growth and metastasis. However, the signaling pathways leading to tumor vascularization are not fully understood. Here, using a transplantable mouse tumor model, we have demonstrated that endogenous IFN-β inhibits tumor angiogenesis through repression of genes encoding proangiogenic and homing factors in tumor-infiltrating neutrophils. We determined that IFN-β-deficient mice injected with B16F10 melanoma or MCA205 fibrosarcoma cells developed faster-growing tumors with better-developed blood vessels than did syngeneic control mice. These tumors displayed enhanced infiltration by CD11b+Gr1+ neutrophils expressing elevated levels of the genes encoding the proangiogenic factors VEGF and MMP9 and the homing receptor CXCR4. They also expressed higher levels of the transcription factors c-myc and STAT3, known regulators of ...
Carcinomata. Cancer of bone always is secondary to cancer in some epithelial organ. The infection may take place by direct extension through the blood or the lymphatics.. In cases of metastatic invasions of bone, spontaneous fractures oftentimes are the first symptom which calls attention to the fact that metastases have occurred.. Treatment. As in other malignant tumors, the indication is for absolute and radical removal whenever possible. Unfortunately, this very seldom can be done, because at the time the bone has become affected by extension to any great degree, radical operation is impossible. Many times, however, extensive operations must be undertaken for the removal of bone. ...
Johns Hopkins researchers say that an experimental anticancer compound appears to have reversed behaviors associated with schizophrenia and restored some lost brain cell function in adolescent mice with a rodent version of the devastating mental illness.
Fingerprint Dive into the research topics of Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors. Together they form a unique fingerprint. ...
IFNγ can act directly on cancer cells to inhibit tumor growth or act on the tumor stroma to promote rejection of established tumors, but it is not clear which stromal cells respond to IFNγ to facilitate tumor rejection. Using a mouse tumor model with inducible IFNγ in fibrosarcoma cells, Kammertoens and colleagues found that IFNγ induction promoted tumor regression mediated by the tumor stroma, not the cancer cells. Specifically, endothelial cells responded to IFNγ and were both necessary and sufficient for tumor regression, whereas the response of hematopoietic cells, including T cells and fibroblasts, to IFNγ was not sufficient to induce tumor regression. Further, IFNγ induction in endothelial cells induced necrosis and promoted the loss of endothelial cells. Mechanistically, IFNγ facilitated a vascular regression that arrested blood flow and promoted tumor ischemia to facilitate tumor regression. This is in contrast to TNF, which caused tumor blood vessels to burst. The controlled ...
BioAssay record AID 710427 submitted by ChEMBL: Binding affinity to TLR2 in human SU.86.86 cells xenografted in Harlan athymic nude mouse tumor assessed as increase in fluorescence at 100 nmol/kg, iv measured up to 24 hrs.
N-(1-(2-(cyclopropylamino)-1,2-dioxoethyl)butyl)-6,6-dimethyl-3-(2-(1-methylcyclohexyl)-2-((((1-(tetrahydro-1,1-dioxido-2-thienyl)cyclohexyl)amino)carbonyl)amino)acetyl)-3-azabicyclo(3.1.0)hexane-2-carboxamide: an HCV NS3 protease inhibitor; structure in first source
These types of tumours are often non cancerous in nature. It is very much similar to the cancer since the growth come along due to the result of abnormal cells. But unlike any other cancer tumour, it is simply unable to spread the other kinds of areas of the body and it will not impact to any nearby tissues. It carries enough which stays at the point of its growth. However, in terms of fatality, these tumours are not lethal or unhealthy though the location of this tumour may cause problems. The mass of the tumour would add pressure over the primary nerve along with the main artery, which compresses the brain content and hence even the benign tumour can be problematic. Some of the probable causes to this tumour include traumatic injury over the tumour location along with the chronic inflammation, which gives undetected infection ...
These types of tumours are often non cancerous in nature. It is very much similar to the cancer since the growth come along due to the result of abnormal cells. But unlike any other cancer tumour, it is simply unable to spread the other kinds of areas of the body and it will not impact to any nearby tissues. It carries enough which stays at the point of its growth. However, in terms of fatality, these tumours are not lethal or unhealthy though the location of this tumour may cause problems. The mass of the tumour would add pressure over the primary nerve along with the main artery, which compresses the brain content and hence even the benign tumour can be problematic. Some of the probable causes to this tumour include traumatic injury over the tumour location along with the chronic inflammation, which gives undetected infection ...
An experimental cancer vaccine from GlaxoSmithKline has failed in a second test - this time against lung cancer - but the British company said it still hoped to identify a sub-group of patients in which it would work.
An experimental cancer drug shrank prostate tumors dramatically and more than doubled survival in 70% to 80% of patients with aggressive cancers, British researchers reported Tuesday.Although the
The purpose of this study was to evaluate the effect of plasma-activated media (PAM) on a multicellular tumor spheroid (MCTS) obtained using HCT116 colon carcin...
Breast cancer is the most common type of cancer that occurs in women and is second only to lung cancer as the leading cause of womens cancer-related deaths. Th...
This 2-arm, randomized, phase III study will investigate the efficacy and safety of the addition of rindopepimut (an experimental cancer vaccine that ma