Methods for identifying Neisseria spp. include conventional and modified carbohydrate degradation procedures, chromogenic enzyme substrate tests, and immunologic coagglutination tests for Neisseria gonorrhoeae. In this study, we evaluated the abilities of the RIM-N carbohydrate degradation system (American MicroScan, Campbell, Calif.), the Gonochek II enzymatic identification system (Du Pont Co., Wilmington, Del.), and the Phadebact Gonococcus coagglutination test (Pharmacia Diagnostics, Piscataway, N.J.) to identify pathogenic Neisseria spp. and Branhamella catarrhalis. Both stock strains and clinical isolates, including 176 N. gonorrhoeae, 173 Neisseria meningitidis, 48 Neisseria lactamica, and 12 B. catarrhalis strains, were tested. The RIM-N identified 98% of the gonococci, 99% of the meningococci, 94% of the N. lactamica strains, and 100% of the B. catarrhalis strains within 1 h. The Gonochek II system identified 99% of the gonococci, 97% of the meningococci, 100% of the N. lactamica ...
Third, some gonococci are able to engage in conjugation, which is essentially bacteria sex! During conjugation, one bacterium uses an appendage called a sex pilus to attach to another bacterium and deliver a circular piece of DNA from the donor to the recipient. The recipient is now in possession of any traits its new DNA encodes.. You know how we humans are officially Homo sapiens? The scientific name for gonococci is Neisseria gonorrhoeae. And, just as we had genetic cousins in the form of Homo neanderthalensis (aka the Neanderthals), so too do Neisseria gonorrhoeae have cousins in the Neisseria genus. Most human-associated Neisseria species dont cause disease, and live peacefully in our upper respiratory tracts. These species include Neisseria flavescens, Neisseria flava, Neisseria perflava, Neisseria mucosa, Neisseria sicca, Neisseria polysaccharea, and more.. When gonococci meet their cousins at a family reunion, they dont swap recipes for potato salad - they swap genetic material. ...
Neisseria perflava ATCC ® 14799D-5™ Designation: Genomic DNA from Neisseria perflava strain 28 TypeStrain=False Application:
Curated}} {{Biorealm Genus}} [[Image:ng-lym1.jpg,thumb,250px,right,Neisseria gonorrhoeae. From [http://neisseria.org/ng/images/ Dr. Ian Boulton.]]] ==Classification== ===Higher order taxa:=== Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae ===Species:=== Neisseria animalis; N. bacilliformis; N. canis; N. cinerea; N. dentrificans; N. dentiae; N. elongata; N. flava; N. flavescens; [[N. gonorrhoeae]]; N. iguanae; N. lactamica; N. macacae; N. meningitidis; N. mucosa; Neisseria perflava; Neisseria pharyngis; Neisseria polysaccharea; N. sicca; N. subflava; N. weaveri; N. sp. {, , height=10 bgcolor=#FFDF95 align=center , NCBI: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=482&lvl=3&lin=f&keep=1&srchmode=1&unlock Taxonomy] Genome: -,font size=2>[http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=Genome&gi=155 Neisseria meningitidis MC58] -[http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=Genome&gi=156 Neisseria meningitidis Z2491 ...
Author Summary Many bacteria are able to secrete toxins targeted against neighboring cells. In order to protect themselves against their own toxin, they also express an
Horizontal gene transfer is an important source of genetic variation among Neisseria species and has contributed to the spread of resistance to penicillin and sulfonamide drugs in the pathogen Neisseria meningitidis. Sulfonamide resistance in Neisseria meningitidis is mediated by altered chromosomal folP genes. At least some folP alleles conferring resistance have been horizontally acquired from other species, presumably from commensal Neisseriae. In this work, the DNA sequence surrounding folP in commensal Neisseria species was determined and compared to corresponding regions in pathogenic Neisseriae, in order to elucidate the potential for inter-species DNA transfer within this region ...
Genus Neisseria has a specie called Neisseria gonorhea or commonly called Gonococcus. It has a gram negative, kidney or bean shaped intracellular diplococcic. This is usually killed when outside of the human body. It is transmitted through sexual intercourse, with an infected partner via infected birth canal of infected mother during delivery; indirectly transmitted via contaminated hands, fomites contaminated with purulent discharges; directly also via oral sex.. Gonorrhea originated from the two Greek words: gono meaning semen and rhein which means flow. It is an acute, inflammatory and infectious disease o the mucus membrane of the genitor-urinary tracts of men and women as well as the eyes of the newborn due to N. Gonorrhoea. Its incubation period usually is 3-5 days after the contact with an infected partner. ...
1JG9: Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose.
The emergence of antibiotic-resistant gonorrhea is considered one of the most pressing problems in infectious disease - just two years ago, the Centers for Disease Control and Prevention named it an urgent threat, and indeed, gonorrhea seems to be evolving resistance to drugs at quite a rapid clip. Gonococci can acquire resistance to antibiotics in three ways.. First, a genetic mutation can endow bacteria with special antibiotic-fighting powers, making it harder for a drug like penicillin to attach to their cells and destroy them. Such a mutant is more likely to gain evolutionary traction if it finds itself in an antibiotic-drenched environment in which resistance to that drug allows it to outcompete other bacteria. Indeed, antibiotic resistance was first documented in the 1940s, just years after sulfonamides and penicillin were introduced as the first effective cures for gonorrhea. Continue reading →. ...
The Neisseria species are believed to be non-clonal bacteria with a high degree of genetic transfer within and between different species [2, 3, 14-18]. Previous reports of transformation in N. meningitidis have suggested that different regions of the genome may have different recombination rates [19, 20]. This work identified the region upstream of folP as particularly active in recombination events. The most obvious example is the insertion of a complete Correia element, upstream of folP in N. lactamica. Correia elements are small putative transposable elements, around 152 base pairs long with inverted repeats at the ends [12]. Hundreds of Correia copies are scattered around the genomes of pathogenic Neisseriae [13, 21, 22] and they have also been reported in N. lactamica [23]. We detected another copy of a Correia repeat in the N. subflava sequence, suggesting that these elements are ubiquitous in the Neisseria genus and possibly was introduced before the divergence into different ...
In the context of our interest in host-pathogen interactions, we are pursuing currently the following projects:. Neisseria. We have developed a novel mouse model to study the mechanisms of commensalism, from the standpoint of both the host and bacterium. The model involves noninvasive inoculation of the well-studied lab mouse with a new commensal Neisseria species isolated from the normal flora of healthy wild mice. The model allows studies of colonization, and the elusive process of persistence, in a variety of mucosal niches, from the relatively well-studied intestinal tract to the less well-studied respiratory tract and oral cavity. Experimentation is guided by a vast store of knowledge on the mouse and close relatives of the bacterium. Using this unique model, we will identify immune processes and mouse genes critical for susceptibility to N. tucsonensis colonization and bacterial genes critical for colonization and persistence.. Valley Fever. Coccidioidomycosis is a serious respiratory ...
Author Summary The closely related bacterial species N. meningitidis, N. gonorrhoeae and N. lactamica exclusively colonise mucosal surfaces in humans. While N. gonorrhoeae leads to gonorrhea, the other two species persist mainly in their host in the absence of disease. N. meningitidis does occasionally cause severe, life threatening illness, however. Little is known about the factors and elements that dictate the unique human interactions exhibited by each species. Moreover, the evolutionary relationships between these species are poorly characterized. Here, we describe two successive alterations in a single gene that can be linked first to all species within the genus Neisseria and then the species N. meningitidis. We also show these signature alterations have phenotypic consequences by affecting core respiratory metabolic processes. These findings have significant implications for the evolution of related bacterial species within a single host and provide a novel perspective on the episodic and
The genus Neisseria contains many species. Most of them are part of the normal flora of humans and animals; only two are human pathogens: Neisseria gonorrhoeae, which causes a sexually transmitted disease of the same name, and Neisseria meningitidis, which causes meningitis. These pathogens often behave like their related commensal cousins in that they establish asymptomatic infection at high frequency. This commensal-like trait was likely inherited by the pathogens as they evolved from commensal species. Supporting this idea is the observation that many N. gonorrhoeae and N. meningiditis genes that mediate pathogen interactions with their hosts are also in the commensals. A major goal of our lab is to determine how commensal and pathogenic Neisseria differentially regulate these host interaction genes, and how these regulatory events might affect their lifecycle in the host.. Another goal of our lab is to use our new mouse model for Neisseria colonization, persistence, and asymptomatic ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
It is important to understand the caveats to interpreting the MenDeVAR Index:. Source of data - These data combine multiple sources of information including: peptide sequence identity through whole genome sequencing; experimental assays developed as indirect measures of the breadth of vaccine protection against diverse meningococci; and assays developed to assess immunogenicity. The Meningococcal Antigen Typing System (MATS)2 assay was used for Bexsero®.. Cross-reactivity definition - An antigenic variant was considered cross-reactive if it had been tested in ≥5 isolates/subjects and was above the accepted threshold in ≥75% of those isolates. This was established through combined analysis of published experimental studies (PMID provided for each variant), not from genomic data. These assays were based on serogroup B disease isolates.. Protein expression - We have not inferred from genomic data, therefore there may be isolates that possess genes but do no express the protein in vivo.. Age of ...
Please select the required isolate ids and loci for comparison - use CTRL or SHIFT to make multiple selections in list boxes. In addition to selecting individual loci, you can choose to include all loci defined in schemes by selecting the appropriate scheme description.. Interactive analysis is limited to 750,000 data points (isolates x loci). If you select more than this then output will be restricted to static tables ...
The insulin signaling pathways play key roles in energy metabolism, growth, and cellular differentiation. The key ligands for these pathways include the hormone insulin and insulin-like growth factors I and II (IGF1 and IGF2). These ligands bind with different affinities to insulin receptor and IGF1 receptor homo- and heteroduplexes. Receptor activation leads to downstream signaling through the MAPK and PI3K signaling pathways, ultimately activating target gene expression. Signaling through the insulin receptor either promotes mitogenesis or glucose and fatty acid storage. This pathway also inhibits lipid and carbohydrate degradation. Signaling through IGF1R promotes cell growth and inhibits apoptosis. Dysregulation of these pathways commonly occurs during carcinogenesis, possibly due to the prominent role of insulin signaling in mitogenesis. Insulin resistance is a common symptom of diabetes and obesity, resulting from dysregulated energy homeostasis ...
The insulin signaling pathways play key roles in energy metabolism, growth, and cellular differentiation. The key ligands for these pathways include the hormone insulin and insulin-like growth factors I and II (IGF1 and IGF2). These ligands bind with different affinities to insulin receptor and IGF1 receptor homo- and heteroduplexes. Receptor activation leads to downstream signaling through the MAPK and PI3K signaling pathways, ultimately activating target gene expression. Signaling through the insulin receptor either promotes mitogenesis or glucose and fatty acid storage. This pathway also inhibits lipid and carbohydrate degradation. Signaling through IGF1R promotes cell growth and inhibits apoptosis. Dysregulation of these pathways commonly occurs during carcinogenesis, possibly due to the prominent role of insulin signaling in mitogenesis. Insulin resistance is a common symptom of diabetes and obesity, resulting from dysregulated energy homeostasis ...
Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, BIOLOGY, NEISSERIA-MENINGITIDIS, POPULATION-STRUCTURE, GENETIC EXCHANGE, GENUS NEISSERIA, STREPTOCOCCUS, RECOMBINATION, PROKARYOTES, DEFINITION, PHYLOGENY, SEQUENCES. ...
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TY - JOUR. T1 - Nasal inoculation of the commensal neisseria lactamica inhibits carriage of neisseria meningitidis by young adults. T2 - A controlled human infection study. AU - Deasy, Alice M.. AU - Guccione, Ed. AU - Dale, Adam P.. AU - Andrews, Nicholas. AU - Evans, Cariad M.. AU - Bennett, Julia S.. AU - Bratcher, Holly B.. AU - Maiden, Martin C.J.. AU - Gorringe, Andrew. AU - Read, Robert C.. N1 - Funding Information: Financial support. This work was supported by Life for a Cure, a charity established by Michelle and John Bresnahan in memory of their son Ryan; and Meningitis UK (now Meningitis Now). Potential conflicts of interest. All authors: No reported conflicts. Funding Information: Acknowledgments. Infrastructure and Service support was provided by the National Institute of Health Research Clinical Research Network, UK. We are grateful to the university volunteers who took part in this project and would also like to thank Abida Nazir and the staff in the Clinical Research Unit at the ...
The availability of new polysaccharide-protein conjugate vaccines against Neisseria meningitidis serogroup C prompted European National Health authorities to carefully monitor isolate characteristics. In Italy, during 1999-2001, the average incidence was 0.4 cases per 100,000 inhabitants. Serogroup B was predominant and accounted for 75% of the isolates, followed by serogroup C with 24%. Serogroup C was isolated almost twice as frequently in cases of septicemia than in cases of meningitis, and the most common phenotypes were C: 2a:P1.5 and C:2b:P1.5. Among serogroup B meningococci, the trend of predominant phenotypes has changed from year to year, with a recent increase in the frequency of B:15:P1.4. Only a few meningococci had decreased susceptibility to penicillin, and, in the penA gene, all of these strains had exogenous DNA blocks deriving from the DNA of commensal Neisseria flavescens, Neisseria cinerea, and Neisseria perflava/sicca. Fluorescent amplified fragment-length polymorphism ...
The genome of Neisseria meningitidis serogroup B strain MC58 contains three genes - nmb0278, nmb0294 and nmb0407 - encoding putative homologues of DsbA, a periplasmic thiol disulphide oxidoreductase protein-folding catalyst of the Dsb protein family. DsbA assists the folding of periplasmic and membrane proteins in diverse organisms. While all three cloned genes complemented the DTT sensitivity of dsbA-null Escherichia coli, they showed different activities in folding specific target proteins in this background. NMB0278 protein was the most active in complementing defects in motility and alkaline phosphatase activity, while NMB0294 was the most active in folding periplasmic MalF. NMB0407 showed the weakest activity in all assays. It is extremely unusual for organisms to contain more than one chromosomal dsbA. Among the members of the genus Neisseria, only the meningococcus carries all three of these genes. Strains of Neisseria gonorrhoeae, Neisseria lactamica, Neisseria cinerea and Neisseria
Fumarase is one of the key enzymes in the TCA cycle and has been implicated in virulence and survival of some microorganisms under suboptimal environmental conditions. In this study, the fumC genes that encode fumarase C (FUMCs) from Neisseria meningitidis, N. gonorrhoeae and N. subflava were identified by homology-based analysis, cloned by polymerase chain reactions and fully sequenced. The inferred primary sequence of neisserial FUMCs showed a high degree of conservation with 97.8-98.7% amino acid identity. However, phylogenetic analysis revealed that these neisserial FUMCs are divergent from class II fumarases found in other microorganisms, rat and human. The putative fumC genes were subcloned into the expression vector, pGEX-6P-1 and efficiently expressed in Esherichia coli BL21. The purified recombinant fusion proteins obtained by affinity chromatography demonstrated high catalytic activities (120-180 U/mg), thus authenticating the identities and functionalities of the cloned genes. Whether ...
A DNA vaccine strategy for effective antibody induction to pathogen-derived antigens -- Antigen identification starting from the genome: A Reverse vaccinology Approach applied to MenB -- Analysis of the immune response to Neisseria meningitidis using a proteomics approach -- Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins -- The use of the pan-Neisseria microarray and experimental design for transcriptomics studies of Neisseria -- Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells -- Visualising PAMP-PRR interactions using nanoscale imaging -- Hydrogen-deuterium exchange coupled to mass spectrometry to investigate ligand-receptor interactions -- Human dendritic cell culture and bacterial infection -- Techniques to measure pilus retraction forces -- A laminar-flow chamber assay for measuring bacterial adhesion under shear stress -- Methods for studying Neisseria meningitidis biofilms ...
A DNA vaccine strategy for effective antibody induction to pathogen-derived antigens -- Antigen identification starting from the genome: A Reverse vaccinology Approach applied to MenB -- Analysis of the immune response to Neisseria meningitidis using a proteomics approach -- Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins -- The use of the pan-Neisseria microarray and experimental design for transcriptomics studies of Neisseria -- Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells -- Visualising PAMP-PRR interactions using nanoscale imaging -- Hydrogen-deuterium exchange coupled to mass spectrometry to investigate ligand-receptor interactions -- Human dendritic cell culture and bacterial infection -- Techniques to measure pilus retraction forces -- A laminar-flow chamber assay for measuring bacterial adhesion under shear stress -- Methods for studying Neisseria meningitidis biofilms ...
Neisseria spp. - Includes:Neisseria gonorrhoeaeNeisseria meningitidis - Neisseria gonorrhoeae - Neisseria meningitidis - Gram-negative diplococciContain lipooligosaccharides (LOS) with strong endotoxin activity - Contain lipooligosaccharides (LOS) with strong endotoxin activity - Facultatively intracellularOften visualized within epithelial cells - Often visualized within epithelial cells - Grows on Thayer-Martin agarSelective chocolate (heated-blood) agar-based medium containing the antibiotics vancomycin, colistin, nystatin and trimethoprimPrevents growth of microbes other than Neisseria - Selective chocolate (heated-blood) agar-based medium containing the antibiotics vancomycin, colistin, nystatin and trimethoprim - Prevents growth of microbes other than Neisseria - Produce IgA proteaseCleave IgA at hinge region, impairing its function at mucosal surfacesImproves mucosal adherence - Cleave IgA at hinge region, impairing its function at mucosal surfaces - Improves mucosal adherence - Increased risk
The Neisseria gonorrhoeae population structure is not clonal [1-5], its panmictic structure being the result of horizontal genetic exchange [6]. The pathogenic Neisseria spp. are naturally transformable [7] and chromosomal changes are largely mediated by homologous recombination. Natural competence for transformation and homologous recombination allow the generation of mosaic genes, such as the divergent opa genes [8, 9], antigenic variation through recombination with silent cassettes, such as in the pilE/pilS system [10, 11], and the horizontal exchange of whole genes or groups of genes in Minimal Mobile Elements (MMEs) [12]. A Minimal Mobile Element (MME) is defined as a region between two conserved genes within which different genes are found in different strains. These elements are described as minimal reflecting the fact that they do not have features suggesting mobilization by associated transposases, nor do they currently appear to have features by which remotely encoded systems would ...
Neisseria mucosa ATCC ® 49233™ Designation: AmMS 138 TypeStrain=False Application: Quality control of MicroScan ® panels
Looking for online definition of Neisseria ovis in the Medical Dictionary? Neisseria ovis explanation free. What is Neisseria ovis? Meaning of Neisseria ovis medical term. What does Neisseria ovis mean?
Looking for online definition of Neisseria in the Medical Dictionary? Neisseria explanation free. What is Neisseria? Meaning of Neisseria medical term. What does Neisseria mean?
After publication of the original article [1] it was identified that an incorrect version of the manuscript has been published. This was caused by a technical error which led to a discrepancy between the editorially-accepted version of the manuscript, and the published version.
The Neisseriaceae are a family[2] of Proteobacteria, within the Neisseriales order. While many organisms in the family are mammalian commensals or part of the normal flora, the genus Neisseria includes two important human pathogens, specifically those responsible for gonorrhea (caused by N. gonorrhoeae) and many cases of meningitis (meningococcal meningitis, caused by N. meningitidis). As a group, the Neisseriaceae are strictly aerobic and Gram-negative, occur mainly in pairs (diplococci), and typically do not have flagella. ...
Tezera, L., Molierinho, S., Virji, M., Jackson, S. K. and Davenport, V. (2008) Differential induction on innate immunity to Neisseria lactamica and N.meningitidis in nasopharyngeal epithelial cells. In: 16th International Pathogenic Neisseria Conference, Rotterdam, 7-12 September 2008. Available from: http://eprints.uwe.ac.uk/7487 ...
Tezera, L., Molierinho, S., Virji, M., Jackson, S. K. and Davenport, V. (2008) Differential induction on innate immunity to Neisseria lactamica and N.meningitidis in nasopharyngeal epithelial cells. In: 16th International Pathogenic Neisseria Conference, Rotterdam, 7-12 September 2008. Available from: http://eprints.uwe.ac.uk/7487 ...
Bacillus amyloliquefaciens strain FZB42 is a free-living bacterium that competitively colonizes plant roots and stimulates plant growth by many different modes of action. The molecular basis of singular beneficial effects that this Plant Growth-Promoting Rhizobacteria (PGPR) exert on their hosts have been studied. To decipher the molecular cross-talk of B. amyloliquefaciens and its host plants as a whole system, an extensive proteomic approach was performed. Reference maps of the extracellular and cytosolic protein fractions were established. The highest number of secreted proteins was observed during stationary growth phase. Identified extracellular proteins belong to different functional classes, with the most prominent classes involved in carbohydrate degradation and transportation of molecules across the cell wall. Cytosolic extracts obtained from cultures grown in 1C and minimal media subjected to the 2 Dimensional Electrophoresis (2 DE), revealed 461 and 245 different protein entries, ...
The genome of the thermophilic fungus Scytalidium thermophilum (strain CBS 625.91) harbours a wide range of genes involved in carbohydrate degradation, including three genes, abf62A, abf62B and abf62C, predicted to encode glycoside hydrolase family 62 (GH62) enzymes. Transcriptome analysis showed that only abf62A and abf62C are actively expressed during growth on diverse substrates including straws from barley, alfalfa, triticale and canola. The abf62A and abf62C genes were expressed in Escherichia coli and the resulting recombinant proteins were characterized. Calcium-free crystal structures of Abf62C in apo and xylotriose bound forms were determined to 1.23 and 1.48 Å resolution respectively. Site-directed mutagenesis confirmed Asp55, Asp171 and Glu230 as catalytic triad residues, and revealed the critical role of non-catalytic residues Asp194, Trp229 and Tyr338 in positioning the scissile α-L-arabinofuranoside bond at the catalytic site. Further, the +2R substrate-binding site residues ...
The wood of the gender Eucalyptus occupies a prominence place among other cellulose sources due to its chemical composition, its low cost, abundance and availability. Among the chemical pulping processes, kraft process is the most extensively one used for the production of cellulosic pulps starting from eucalyptus wood. The anthraquinone (AQ) usage in the pulping has as main purposes to increase the delignification rate as well as to protect the pulp from the carbohydrate degradation. The present work has aimed to use the anthraquinone as an addictive in the cooking seeking to reduce the load of applied sulphidity without harming the quality of the pulp. The kraft and kraft/AQ cooking were accomplished in rotative laboratorial digester being varied the active alkali initially (10, 13, 16 and 19%) and, later, the sulphidity (5, 10, 15, 20 and 25%), maintaining the other conditions constant aiming to obtain pulp with kappa number close to nine. Starting from the variation of the active alkali and ...
General Information: Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria ...
General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, ...
|strong|Rabbit anti |em|Neisseria meningitidis|/em| antibody|/strong|reacts with |i|Neisseria meningitidis |/i| serogroups A, B and C recognizing multiple antigens. Other serogroups have not been test…
Neisseria meningitidis, a causative agent of bacterial meningitis, has a relatively small repertoire of transcription factors, including NMB0573 (annotated AsnC), a member of the Lrp-AsnC family of regulators that are widely expressed in both Bacteria and Archaea. In the present study we show that NMB0573 binds to l-leucine and l-methionine and have solved the structure of the protein with and without bound amino acids. This has shown, for the first time that amino acid binding does not induce significant conformational changes in the structure of an AsnC/Lrp regulator although it does appear to stabilize the octameric assembly of the protein. Transcriptional profiling of wild-type and NMB0573 knock-out strains of N. meningitidis has shown that NMB0573 is associated with an adaptive response to nutrient poor conditions reflected in a reduction in major surface protein expression. On the basis of its structure and the transcriptional response, we propose that NMB0573 is a global regulator in Neisseria
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TY - JOUR. T1 - Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera. AU - Mendum, Tom A.. AU - McFadden, Johnjoe. A2 - Newcombe, Jane. A2 - Mannan, Ahmad A. A2 - Kierzek, Andrzej M. PY - 2011/12/30. Y1 - 2011/12/30. N2 - BackgroundNeisseria meningitidis is an important human commensal and pathogen that causes several thousand deaths each year, mostly in young children. How the pathogen replicates and causes disease in the host is largely unknown, particularly the role of metabolism in colonization and disease. Completed genome sequences are available for several strains but our understanding of how these data relate to phenotype remains limited.ResultsTo investigate the metabolism of N. meningitidis we generated and then selected a representative Tn5 library on rich medium, a minimal defined medium and in human serum to identify genes essential for growth under these conditions. To relate these data to a ...
Bacterial infection of human vasculature can lead to unregulated systemic activation of coagulation and innate immunity and rapidly becomes life threatening. Neisseria meningitidis is a vascular pathogen that causes fatal septic shock and meningitis. Post-mortem histological analysis of tissues from individuals infected with N. meningitidis show large bacterial aggregates in close association with the vascular wall of small vessels. The ability of this bacterium to colonize blood vessel endothelium is likely to impact its capacity to both multiply in the blood stream and reach the brain. This process is referred to as vascular colonization. Recent work from our group exploring the early steps in N. meningitidis vascular colonization will be reported, from attachment to proliferation and dissemination, focusing on the bacterial-host interaction.. Selected publications. ...
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Mendum , T A , Newcombe , J , Mannan , A A , Kierzek , A M & McFadden , J 2011 , Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera , Genome Biology , vol. 12 , R127 . https://doi.org/10.1186/gb-2011-12-12- ...
Neisseria meningitidis, IgG, Vaccine Response, MAID (Quest). Get know how much does lab test cost. Direct access testing with or without insurance.
Domain combinations containing the TrpR-like superfamily in Neisseria meningitidis Z2491. Domain architectures illustrate each occurrence of the TrpR-like superfamily.
Antigenic potential of a highly conserved Neisseria meningitidis lipopolysaccharide inner core structure defined by chemical synthesis
Neisseria gonorrheae bacteria are the causative agent of the second most common sexually transmitted infection in the world. The bacteria move on a surface by means of twitching motility. Their movement is mediated by multiple long and flexible filaments, called type IV pili, that extend from the cell body, attach to the surface, and retract, thus generating a pulling force. Moving cells also use pili to aggregate and form microcolonies. However, the mechanism by which the pili surrounding the cell body work together to propel bacteria remains unclear. Understanding this process will help describe the motility of N. gonorrheae bacteria, and thus the dissemination of the disease which they cause. In this article we track individual twitching cells and observe that their trajectories consist of alternating moving and pausing intervals, while the cell body is preferably oriented with its wide side toward the direction of motion. Based on these data, we propose a model for the collective pili ...
Neisseria meningitis is a human commensal bacterium that occasionally causes life-threatening disease. As with a number of other bacterial pathogens, meningococcal populations comprise distinct lineages, which persist over many decades and during global spread in the face of high rates of
Eine einfache Messung der ATP Assay und lebenden/Toten Färbung Methode dienten zu quantifizieren und zu visualisieren, Neisseria...
What do UK sexual health clinicians think about saliva as a transmissible vector for Neisseria g onorrhoea e in men who have sex with men? ...
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As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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It is also called knock knees. It is a condition in which the knee angle is in and they touch each other when the legs are straightened ...