Here, we reported the case of a patient who experienced persistent bone marrow necrosis after ATRA and IDA induction therapy for APL, despite cessation of ATRA. Although ATRA-induced bone marrow necrosis has been documented,18-20 this case is notable in that our patient demonstrated continual bone marrow necrosis several months subsequent to stopping ATRA therapy. It is interesting to note that the patient had evidence of hematopoietic recovery despite the necrotic effects of ATRA and shifting to ATO treatment.. Bone marrow necrosis is conjectured to result from poor blood supply to the marrow21 or increased oxygen demand of the marrow, as evidenced in necrosis of other tissue types. The most common cause of bone marrow necrosis is malignancy, in particular hematologic malignancy, including acute leukemia.18,21,22 It is reasonable to postulate that the APL by itself could have caused the bone marrow necrosis as evidenced in this patient23; however, one would have expected necrosis on the initial ...
Synonyms for focal necrosis in Free Thesaurus. Antonyms for focal necrosis. 3 synonyms for necrosis: gangrene, mortification, sphacelus. What are synonyms for focal necrosis?
Unlike the other terminology described in this section, Ischemic Necrosis does not refer to a particular morphology of necrosis but instead references a particular necrotic etiology. Ischemic Necrosis refers to necrosis of a tissue due to the etiological process of ischemia. In nearly all tissues, Ischemic Necrosis results in a pattern of Coagulative Necrosis except for the CNS in which it manifests as a pattern of Liquifactive Necrosis. It should be pointed out that necrotic areas caused by ischemia are termed "Infarctions ...
TY - JOUR. T1 - Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. AU - Yang, X. U.. AU - Bradham, Cynthia. AU - Brenner, David A.. AU - Czaja, Mark J.. PY - 1997. Y1 - 1997. N2 - To deter-mine whether intracellular signaling events involved in apoptosis may also mediate necrosis, the role of the transcription factor AP-1 was investigated in a hepatoma cell model of cellular necrosis induced by oxidant stress. Treatment of the human hepatoma cell line HuH-7 with H2O2 caused dose-dependent necrosis as determined by light microscopy, fluorescent staining, and an absence of DNA fragmentation. H2O2 treatment led to increases in c-fos and c-jun mRNA levels, Jun nuclear kinase activity, and AP-1 DNA binding. AP-1 transcriptional activity measured with an AP-1-driven luciferase reporter gene was also increased. To determine whether this AP-1 activation contributed to H2O2-induced cell necrosis, HuH-7 cells were stably transfected with an antisense c-jun expression vector. ...
Seventy-five cases of hemorrhagic necrosis of the gastrointestinal tract were analyzed and compared with the entire autopsy population as control. The disease occurred most frequently in association with shock, which was present in 80 per cent of the cases with the gastrointestinal lesions.. The incidence of heart disease was higher in the cases of hemorrhagic necrosis than in the control group. The role of cardiac dysfunction in the etiology of hemorrhagic necrosis is emphasized as are the roles played by the bacterial toxins and shock. All three conditions have been shown to result in marked reduction of the intestinal blood flow and venous stasis.. Hemorrhagic necrosis of the gastrointestinal tract probably represents a conglomeration of microinfarcts of the mucosa secondary to markedly decreased local blood flow. Vasopressor agents have produced no beneficial effect; the effect of vasodilators remains to be determined.. ...
Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger J, et al. 1998. Vaccination with irradiated autologous melanoma cells engineered to secrete human GM-CSF generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A 1998;95: 13141-6 ...
Annexin A1 is an intracellular calcium/phospholipid-binding protein that is involved in membrane organization and the regulation of the immune system. It has been attributed an anti-inflammatory role at various control levels, and recently we could show that annexin A1 externalization during secondary necrosis provides an important fail-safe mechanism counteracting inflammatory responses when the timely clearance of apoptotic cells has failed. As such, annexin A1 promotes the engulfment of dying cells and dampens the postphagocytic production of proinflammatory cytokines. In our current follow-up study, we report that exposure of annexin A1 during secondary necrosis coincided with proteolytic processing within its unique N-terminal domain by ADAM10. Most importantly, we demonstrate that the released peptide and culture supernatants of secondary necrotic, annexin A1-externalizing cells induced chemoattraction of monocytes, which was clearly reduced in annexin A1- or ADAM10-knockdown cells. Thus, ...
Red Bamboos Dr. Toscano from Clearwater Florida finds a way to reverse skin necrosis without surgery and his findings reach national attention.
ALT: 15,360 (rat normal 29-65). Contributors Diagnosis and Comments: Moderate to severe, acute, multifocal to coalescing centrilobular hepatic necrosis.. Acute coagulative necrosis of the centrilobular region (Zone 3 of the liver acinus) is present throughout this section of rat liver. The necrosis of hepatocytes is most severe in zone 3, with complete dissolution of cytoplasmic components, karyorrhexis and karyolysis, and breakdown of sinusoidal endothelium with blood-filled lakes in the immediate vicinity of central veins. Phagocytosis by large cells assumed to be Kupffer cells is evident in the centrilobular region, and by Kupffer cells and intact hepatocytes at the periphery of the necrotic zones. Large numbers of neutrophils and lesser numbers of other mononuclear cells are abundant in or at the periphery of the necrotic zone (often approximating the Zone 2-3 boundary). Increased homogeneity of the hepatocytic cytoplasm with increased finely granular basophilia exists in the midzonal to ...
Official press release:. For a good while now, Akral Necrosis are working on their new full-length, the second in the history of the group. Recordings are still ongoing at Studio148 under the supervision of Marius Costache, but the process is near its end. Time has come for the band to announce the name of the new material:. The title of the second Akral Necrosis opus is Underlight.. The contrasting juxtaposition of the two words is appropriate and necessary to incorporate multiple meanings, evoked by the lyrical content of the material. Unlike the bands debut album, Pandemic Dominion, built around a narrative line, their upcoming effort quits the classic format, but keeps a well-defined conceptual axis, framed by a more violent and elaborate sound.. After the successful collaboration that led to the release of the (inter)SECTION split, Loud Rage Music and Akral Necrosis are joining forces again scheduling the release of this heinous Black Thrash Metal monster titled Underlight at the beginning ...
TY - JOUR. T1 - Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide.. AU - Honda, O.. AU - Kuroda, Masahiro. AU - Joja, I.. AU - Asaumi, Jun-Ichi. AU - Takeda, Yoshihiro. AU - Akaki, S.. AU - Togami, I.. AU - Kanazawa, Susumu. AU - Kawasaki, S.. AU - Hiraki, Y.. PY - 2000/2. Y1 - 2000/2. N2 - Using a new system developed by us for acquiring microscopic images automatically, we compared the morphological changes that apoptotic cells undergo with changes in the staining pattern of annexin V-enhanced green fluorescent protein (AV-EGFP) and propidium iodide (PI) in individual cells. Jurkat cells were treated with 5 mM CaCl2 alone, anti-Fas antibody and heating at 42 degrees C for 30 min or 46 degrees C for 60 min, and then were incubated in medium with 5 mM CaCl2. Time-lapse DNA fragmentation analysis and morphological observation revealed that the anti-Fas antibody and heating at 42 degrees C for 30 min ...
Looking for selective myocardial cell necrosis? Find out information about selective myocardial cell necrosis. 1. the death of one or more cells in the body, usually within a localized area, as from an interruption of the blood supply to that part 2. death of plant... Explanation of selective myocardial cell necrosis
Comparison of the culture of C. perfringens to the presence of clostridia-like bacteria observed on ileal smears is shown in Table 2.. Histopathology. The intestines of 36 pigs that had died of haemorrhagic enteropathy were examined histologically. Advanced autolysis of the sampled tissues precluded histological evaluation in seven of these cases.. In all of the remaining cases (29), the histopathological findings were essentially identical, varying only in degree. The three basic lesions that were consistently found in most cases, to varying degrees, were: necrosis of the intestinal mucosa and congestion and haemorrhages in the intestinal wall. Rod-shaped bacterial bacilli were usually, but not always, present on and in the intestinal mucosa.. Mucosal necrosis was present in all cases. It was invariably linear, that is, parallel to the mucosal surface, and was sharply delimited from the underlying non-necrotic mucosa. The comparative severity of mucosal necrosis in the duodenum, jejunum and ...
AIMS--To compare in situ end-labelling (ISEL) of apoptosis in lung carcinoma with quantitative and semiquantitative light microscopic assessment and ultrastructural observations. METHODS--ISEL of apoptosis was evaluated in 42 lung carcinomas (24 squamous cell carcinomas, 12 adenocarcinomas and six small cell carcinomas). Results were correlated semiquantitatively with the extent of apoptosis in haematoxylin and eosin stained sections, with apoptotic indices and with ultrastructural observations (nine cases). RESULTS--In each tumour type the extent of apoptosis identified by ISEL correlated with that observed on light and electron microscopy. Tumour cells undergoing apoptosis showed either uniform nuclear staining with a surrounding "halo" or peripheral nuclear membrane staining. The latter pattern was more prominent in small cell carcinoma and correlated ultrastructurally with early apoptosis. A variable proportion of apoptotic cells and apoptotic bodies were unlabelled. Necrotic tumour cells ...
Dendritic cells (DC) loaded with tumor antigens from apoptotic/necrotic tumor cells are commonly used as vaccines for cancer therapy. However, the use of dead tumor cells may cause both tolerance and immunity, making the effect of vaccination unpredictable. To deliver live tumor cargoes into DC, we developed a new approach based on the labeling of tumors with a phospholipid eat-me sign
(MedPage Today) -- Small study finds elevated incidence of high-grade transmural infarcts via Plaque Rupture Linked to Extensive Ischemic Necrosis in STEMI by from Blogger http://ift.tt/2pAS1yAvia https://www.youtube.com/channel/UC6RqJb8h-y4xS4g-vzofotQ/videos
Since oxygen is mainly bound to hemoglobin in red blood cells, insufficient blood supply causes tissue to become hypoxic, or, if no oxygen is supplied at all, anoxic. This can cause necrosis (i.e. cell death). In very aerobic tissues such as heart and brain, at body temperature Necrosis due to ischemia usually takes about 3-4 hours before becoming irreversible. This and typically some collateral circulation to the ischemic area accounts for the efficacy of "clot-buster" drugs such as Alteplase, given for stroke and heart-attack within this time period. However, complete cessation of oxygenation of such organs for more than 20 minutes typically results in irreversible damage ...
1/day each: plane shift, telekinesis. Actions. Multiattack. The githyanki doorkeeper makes two attacks, using its necrotic greatsword and/or its withering blast if corporeal, or its withering touch and/or its withering blast if incorporeal.. Necrotic Greatsword. Melee Weapon Attack: +9 to hit, reach 5 ft., one target. Hit: 15 (3d6+5) slashing damage plus 7 (2d6) necrotic damage.. Withering Touch. Melee Weapon Attack: +6 to hit, reach 5 ft., one target. Hit: 16 (4d6+2) necrotic damage plus 7 (2d6) cold damage.. Withering Blast. Ranged Spell Attack: +8 to hit, range 120 ft., one target. Hit: 15 (3d6+4) necrotic damage plus 7 (2d6) cold damage.. Tags: 5E D&D, monsters, undead ...
histophotograph of a longitudinal section through the optic nerve showing vitreous inflammatory cells over the optic disc, hemorrhagic necrosis of the retina, subretinal exudation, and an occluded retinal vessel (arrow and inset ...
The model presented here is based on the model we described earlier (10), but we improved it by rewriting the entire set of differential equations to make the model quantitatively more precise, to recognize 3 rather than 2 cell types, and most importantly by including the effect of antigen shedding, which was not included in the original model.. An important advantage of this model is that it can handle tumors of any size and yields total tumor volume information dynamically while considering only one representative unit of a modest and constant size. Because the model assumes that the total cell density is uniform and unchanged, this is not a good model for poorly vascularized, necrotic regions of the tumor. However, the efficacy of RIT is an issue for well vascularized, rapidly growing tumor; it may be less important for slowly growing, necrotic regions of a tumor. Also, although the cell density is assumed constant for any one tumor model, one can study the effect of density changes by doing ...
Learning Point of the Article: Plain radiographs can fail to detect impending soft tissue damage secondary to comminuted calcaneal fractures. Case Report , Volume 9 , Issue 2 , JOCR March - April 2019 , Page 11-14 , Tarek Taha, Karim Mahmoud, Ahmed Khalil Attia, Maged M Mekhaimar. DOI: 10.13107/jocr.2250-0685.1346 Authors: Tarek Taha[1], Karim Mahmoud[2], Ahmed Khalil Attia[2], Maged M Mekhaimar[2] [1]Department of Medical.... Read More ...
He had low-grade elevated temperature. Vital signs were otherwise normal. Tenderness and firmness of the epigastrium and left upper abdominal quadrant were noted. There was no palpable mass.. Leukocytosis was noted. Basic metabolic profile, hepatic chemistries, lipase, lactate, and urinalysis were all normal. Computed tomographic scan of the abdomen and pelvis showed an 8.0 x 9.0 x 9.6 cm, heterogeneous, left-sided abdominal mass, inseparable from adjacent loops of small bowel, with irregular peripheral enhancement and evidence of central necrosis. There was no bowel obstruction. Based on the imaging findings, the interpreting radiologist raised concern for malignancy. Percutaneous biopsy of the abdominal mass was planned. However, fevers persisted, leukocytosis worsened, and repeat imaging showed further enlargement of the mass, with findings suspicious for bowel perforation and abscess. Percutaneous drainage of 650 milliliters of purulent fluid was performed. Culture of this fluid ultimately ...
Ken, I am just as skeptical. Mostly due to the most recent photo taken by a lady who braided Jahis hair about a year ago. Jahi was notably smaller, necrosis on her mouth etc. we have all seen that photo. I think she is posting an old video for a reason. It was recently publicized that they could once again prove that Jahi is alive. I remember reading that in Dr. Popes blog, that the defendants would be allowed to have their own doctors examine Jahi. I really think that Nailah has gone to posting more than normal videos and pics lately thinking that will be enough to convince a judge. She is thinking if she shoves enough material into the media, that no exam will be needed. That is why I think these are old videos. She went from having necrosis on her mouth area to looking plump again with lips that look like they did on day 1?. Delete ...
Treatment of patients with the VEGFR TKIs sorafenib and sunitinib can lead to periods of tumor stability, but resistance to therapy is inevitable. We used a mouse model to define mechanisms by which resistance develops and found that components of the IFNγ signaling pathway are lost with sunitinib or sorafenib therapy. Our data also show that CXCL9 treatment delays resistance to sunitinib in 786-O- and A498-derived tumors and that one mechanism by which this occurs is by prolongation of the antiangiogenic effects of sunitinib. These data suggest that angiostatic pathways are suppressed as a result of VEGFR TKI therapy and set the stage for the subsequent development of resistance to therapy.. In the setting of VEGFR inhibition, RCC tumors undergo extensive necrosis (22). In the setting of this necrosis and accompanying hypoxia/nutrient deprivation, tumors may undergo compensatory changes, including the induction of salvage angiogenesis pathways. We propose that the environmental stress ...
Video interview by Prof. Paolo Vescovi Faculty of Medicine and Surgery, University of Parma, on the danger of jaw necrosis following the use of bisphosphonates: who are the patients at risk. More on www.youmed.it
Previous experience with High Intensity Focused Ultrasound (HIFU) has demonstrated that HIFU induces coagulative necrosis in tumor tissues and controls tumor gr...
Methods and systems for determining patient specific treatment parameters for delivering vapor to the lung to treat lung tissue. In some embodiments vapor is delivered to the lung to cause coagulative necrosis, inducing fibrosis and thereby reducing the volume of at least one segment of the lung. The delivery parameters can be adjusted depending on the desired degree of injury to be induced in the lung tissue.
considered to bring the greatest reduction the enlarged prostate or stop the prostate a coagulative necrosis below the urethral surface that allows for less obstruction is pressing against the urethra is removed to allow urine to flow easily. The procedure receptors. Men are given local anesthesia involves an electrical loop that cuts tissue for the procedure. This procedure involves • Alpha Blockers: These drugs dont ...
Co-financing: the Foundation for Assistance to Small Innovative Enterprises (FASIE) 3.000.000 rubles. One of the purposes of the project is to study an effect of introduction of stem cells in blood channel for different terms after ischemic stroke caused by bandaging the middle-brain artery in rat line «Vistar-Kioto». Thus for an estimation of an effect of introduction of stem cells it was planned to use following basic criteria: histological picture in necrotic zone caused by bandaging an artery; results of behavioral testing of animals. Taking into account the results of preliminary experiments it is possible to approve, that introduction of autologous stem cells on early terms after infringement of blood flow will allow to improve essentially a condition of damaged tissues due to preservation of vascular system, de novo formation of vessels in necrotic zone, restoration of tissues of the damaged organs due to the differentiation of stem cells.. The projects which are carried out at the ...
Ischemia: Lack of oxygen due to inadequate perfusion. Infarction: Tissue necrosis due to sustained loss of perfusion.. Risk Factors for CAD . Male |45Female | 55Family history of premature CADCigarette smokingHypertensionLipid abnormalitiesDiabetesMenopause (esp....
Abstract: Calcium balance was impaired in a body during myocardium necrosis. Emotional stress, which preceded the myocardial necrosis, fortified these impairments. This was manifested as follows: an increased rate of calcium excretion and elevated hypocalcemia, accumulation of calcium in liver tissue, aorta, brain hemispheres and a decrease of its content in the intact tissue of left heart ventricle ...
PNC-27 anti-cancer peptide, derived from the MDM2 binding site of p53 and linked to a membrane residency peptide (MRP), has been shown to cause necrosis of cancer cells without affecting untransformed cells. PNC-27 was also able to eradicate pancreatic tumor xenografts in mice (Michl et al, Int. J of Cancer, 2006). Recently, we have identified the mechanism of action of this peptide as due to formation of oligomeric pores in the plasma membrane (PM) of cancer cells but not in the PM of untransformed cells. The mechanism of pore-formation by PNC-27 closely resembles the pore-formation process by streptolysin-O, melittin and similar pore-forming agents. We have shown MDM2 as a targeting molecule that leads to PNC-27 selectivity towards cancer cells by its mis-localization to cancer cell PM (Sarafraz-Yazdi et al, PNAS, in press). Examining purified PM of a variety of cancer cells by immunoblotting, we now provide evidence for multiple MDM2 protein variants, and that were absent in the PM of normal ...
Now this is the coolest.. Literally.... New Scientist Tech - Technology - Plasma needle could replace the dentists drill.. According to the article, this plasma needle can target specific types of cells, and cause necrosis, leaving other types of cells intact and unharmed... AWESOME! all without a knife, and at "regular" temperatures... I love science! ...
(KudoZ) English to Georgian translation of Myocardial necrosis biomarkers sample: მიოკარდიუმის ნეკროზის ბიომარკერების ნიმუში [Name of a Course - Medical (general) (Medical)].
When students are asked to compare and contrast two types of cell death: necrosis and apoptosis, the same answers come back:. Apoptosis is programmed cell death.. Necrosis is premature cell death.. All the right things are said but when we then look at a biopsy, they are unsure if necrotic areas are showing necrosis or apoptosis. They dont seem to be getting the underlying concepts.. So, what do you think of the following car death analogy?. ...
Filaga Imaging, LLC Induced for example, by mistake during gavage of liquid test formulation into the trachea Irritation of bronchial and alveolar epithelium by chemical(s) As above Can happen even if the technician who treats do take filagra by gavage is experienced Pneumonia (see above) necrosis Do take filagra (irritation) As a consequence of cell Often restitutio ad integrum Page 477 450 Ettlin and Filaga пFigure 1 Liver Focal necrosisвA focus of homogenous eosinophilic (pink) necro- tic hepatocytes (ф) compatability Filagra to a lobular central vein Takee. In compari- son, Yu J, Krasinska KM et al.
Monocyte/macrophages contribute centrally to wound healing. Their known functions include removal of necrotic debris, propagation of angiogenesis, and regulation of extracellular matrix turnover (23,25). These phagocytes elaborate regulatory cytokines, chemokines, and proteolytic enzymes, all of which participate in tissue repair (1-4). Experimental (16,26) and clinical data (27) show that abrogation of monocytes compromises infarct healing. However, little is known about the downregulation of innate immune cell activity and associated inflammation after the initial burst triggered by ischemic myocardial injury. Here we show that effective infarct healing necessitates timely and coordinated resolution of inflammation. The endogenous repair response that follows MI requires immune cell populations that are profoundly altered during atherosclerosis, the condition that causes MI in most patients. Specifically, we found that Ly-6Chimonocytes, which are chronically expanded in the blood pool of ...
What does this information mean? Related quests The Lost Artifacts History of the Condemned Catacomb The mobs listed below share spawn points. If you need more of one, kill the others to improve spawn chances. a Necrosis beldame, a Necrosis elite guard, a Necrosis seer A Necrosis beldame...
What does this information mean? Related quests The Lost Artifacts History of the Condemned Catacomb The mobs listed below share spawn points. If you need more of one, kill the others to improve spawn chances. a Necrosis beldame, a Necrosis elite guard, a Necrosis seer A Necrosis elite guard...
Necrosis and apoptosis are differentiated by their causes, with necrosis being the accidental result of interactions with pathogens and apoptosis being the product of a programmed cell mechanism....
When a living organisms cells or tissues die or degenerate, the condition is called necrosis. In a plant, necrosis causes leaves, stems and other parts to darken and wilt....
தின்குழியமை என்பது விழுங்கி அழிக்கும் செயல்முறையைக் குறிக்கும். பெருவிழுங்கியின் முக்கியமான தொழில்களில் ஒன்று நுரையீரலில் முதிர்ச்சியடையாமலே புறக்காரணிகளால் இறந்து போகும் கலங்களை (necrotic cells) விழுங்கி அழித்தல் மூலம் அகற்றுதல் ஆகும். நீடித்த அழற்சி நிலைகளில், இவ்வாறு இறந்த கலங்கள் அகற்றப்படுவது அவசியமாகும். பழுதுபட்ட கலங்கள், சிதைந்த கலங்களை, இப்படியான விழுங்கும் ...
See also: Putrefying Cadaverment, ex-Impulsive Disembowelment, ex-Abhorrent Deformity, ex-Flesh Casket, ex-Necroptic Remnants ...
TY - JOUR. T1 - Expect skin necrosis following penile replantation. AU - Tuffaha, Sami. AU - Budihardjo, Joshua D.. AU - Sarhane, Karim A.. AU - Azoury, Saïd C.. AU - Redett, Richard. PY - 2014. Y1 - 2014. UR - http://www.scopus.com/inward/record.url?scp=84922482148&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84922482148&partnerID=8YFLogxK. U2 - 10.1097/PRS.0000000000000901. DO - 10.1097/PRS.0000000000000901. M3 - Article. C2 - 25415107. AN - SCOPUS:84922482148. VL - 134. SP - 1000e-1004e. JO - Plastic and Reconstructive Surgery. JF - Plastic and Reconstructive Surgery. SN - 0032-1052. IS - 6. ER - ...
The effect of propranolol on the severity of myocardial necrosis following 40 minutes of temporary coronary artery occlusion was assessed in dogs. The circumflex coronary artery was occluded 1-2 cm from the aorta in open-chest dogs anesthetized with sodium pentobarbital. One group of dogs was untreated and a second group received propranolol (5.0 mg/kg, iv) 10 minutes prior to the occlusion. After 40 minutes the clamp was removed and arterial perfusion was restored. Dogs which survived this procedure were killed 2-5 days later for gross and histologic assessment of the necrosis. The relative area of necrosis (percent of fibers involved) in the posterior papillary muscle of each heart was quantified from stained histologic sections prepared from serial longitudinal slices of each posterior papillary muscle. Dogs treated with propranolol showed significantly less necrosis than did untreated controls, but the mechanism of the drugs action remains unknown. During coronary artery occlusion, ...
TY - JOUR. T1 - Retinal necrosis following varicella-zoster vaccination. AU - Gonzales, John A.. AU - Levison, Ashleigh L.. AU - Stewart, Jay M.. AU - Acharya, Nisha R.. AU - Margolis, Todd P.. PY - 2012/10. Y1 - 2012/10. UR - http://www.scopus.com/inward/record.url?scp=84867390202&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84867390202&partnerID=8YFLogxK. U2 - 10.1001/archophthalmol.2012.2255. DO - 10.1001/archophthalmol.2012.2255. M3 - Article. C2 - 23044970. AN - SCOPUS:84867390202. VL - 130. SP - 1355. EP - 1356. JO - JAMA Ophthalmology. JF - JAMA Ophthalmology. SN - 2168-6165. IS - 10. ER - ...
Intravenous injection of 25 micrograms of bacterial endotoxin on day 9 of growth of the SA1 sarcoma results in extensive necrosis of the core of this tumor and in its subsequent complete regression. Tumor hemorrhagic necrosis and regression failed to occur in mice that were given a subcutaneous injection of cortisone acetate or dexamethasone 12 h before being giving endotoxin. Inhibition of tumor hemorrhagic necrosis and regression by glucocorticoids was associated with inhibition of endotoxin-induced intratumor TNF production that normally takes place several h after endotoxin is given. In contrast, glucocorticoids had no effect on the ability of intravenously injected rTNF to cause tumor hemorrhagic necrosis and regression. The results lend further support to the belief that TNF is the predominant mediator of endotoxin-induced hemorrhagic necrosis of established murine tumors, and that hemorrhagic necrosis is a prerequisite for the immunologically mediated regression that follows. ...
SOTO-DOMINGUEZ, Adolfo et al. Early Administration of Peroxisomicine A1 (T-514 Extracted from K. parvifolia Seeds) Causes Necrosis of Implanted TC-1 Cells without Affecting Target Organs in a Murine Model. Int. J. Morphol. [online]. 2012, vol.30, n.1, pp.284-289. ISSN 0717-9502. http://dx.doi.org/10.4067/S0717-95022012000100051.. Peroxisomicine A1 (PA1), one of the toxins isolated from seeds of plants of the Karwinskia genus, whose targets organs are the liver, kidney, and lungs. There is a selective toxicity in vitro to cancer-cell lines derived from the lungs, liver, and colon, compared to normal cell lines. PA1 caused apoptosis in several cancer-cell lines in culture. In toxic doses to rodents, it causes extensive apoptosis in the liver, kidney, and lungs. In our study we were interested in evaluating, for the first time, the morphological effects of administration of PA1 to implanted TC-1 cells and in the target organs in vivo. The TC-1 cells were cultured and injected into the hind limb of ...
We made a straight incision at the dorsal MTP joint. We expanded the joint capsule to avoid the inward extensor hallucis longus (EHL) tendon. Articular cartilage of the great toe was invaded by synovitis of rheumatoid arthritis. We closed the skin without significant problems. The patient began indoor walking with full weight‐bearing 1 week after surgery. All stitches were removed 14 days after surgery. The wound of the right foot presented no issues, but we found that the wound of the left foot was macerated, and the EHL tendon was exposed from the wound site. The wound was 3 × 4 cm in size. NPWT was performed on the wound site on the same day, but the wound did not close. Three weeks later, secondary wound closure was attempted and the implant was removed. We immobilized the MTP joint by K‐wire; however, the EHL tendon remained exposed (Figure 1B). By the end of October 2014 (1 month postsurgery), an extensor digitorum brevis (EDB) flap was used to cover skin necrosis (Figure 1C,D). Bone ...
TY - JOUR. T1 - Idiopathic and diabetic skeletal muscle necrosis. T2 - Evaluation by magnetic resonance imaging. AU - Kattapuram, Taj M.. AU - Suri, Rajeev. AU - Rosol, Michael S.. AU - Rosenberg, Andrew. AU - Kattapuram, Susan V.. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Objective: Idiopathic and diabetic-associated muscle necrosis are similar, uncommon clinical entities requiring conservative management and minimal intervention to avoid complications and prolonged hospitalization. An early noninvasive diagnosis is therefore essential. We evaluated the magnetic resonance imaging (MRI) characteristics of muscle necrosis in 14 patients, in eight of whom the diagnoses were confirmed histologically. Design and patients: Two experienced musculos keletal radiologists performed retrospective evaluations of the MRI studies of 14 patients with the diagnoses of skeletal muscle infarction. In 10 cases gadolinium-enhanced (T1-weighted fat-suppressed) sequences were available along with T1-weighted, T2-weighted ...