If youve had a heart attack or stroke, paramedics, doctors, and nurses follow standardized protocols for what to do right away, and their efforts improve your odds for a full recovery. Thats not the case if you have a body-wide infection known as sepsis, which can be fatal within a few hours and is often not diagnosed until it is too late. Now, a new, multicenter research consortium, called Protocolized Care for Early Septic Shock (ProCESS), is beginning a large-scale study to determine whether specific interventions can halt the progression to severe sepsis and septic shock. Key to the project is determining whether there are "golden hours" during which prompt, rigorous, standardized care can save patients lives. The project may establish the first set of standard procedures to diagnose and treat sepsis in emergency departments. The National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, launched the project this month with a grant totaling more ...
We learned this morning that Brian K. Kobilka of Stanford University School of Medicine, whose research is supported by NIGMS and other parts of NIH, will share the 2012 Nobel Prize in chemistry with Robert J. Lefkowitz of Duke University Medical School, a long-time grantee of the National Heart, Lung, and Blood Institute. They are being recognized "for studies of G-protein-coupled receptors.". Their seminal work, primarily involving the β-adrenergic receptor, has widened understanding of how these biologically and medically important proteins operate. It has also contributed to an expanding library of related structures, which have been notoriously difficult to obtain. And it complements the ongoing efforts of many other researchers, including those funded through a variety of special NIH activities, among them the NIH Common Fund Structural Biology Program, which NIGMS helps administer.. Dr. Kobilkas "molecular masterpiece," the high-resolution structure of the β2-adrenergic receptor ...
Prior to joining the Centre for Science Communication, Nancy developed and delivered the science communication undergraduate and graduate programs at the University of Western Australia, 2002 - 2014. Nancy was a professional science communicator with a cooperative research centre and an agricultural research scientist before becoming a science communication academic. She notes,
Weibel-Palade bodies are secretory granules of vascular endothelial cells specialized in the storage of von Willebrand factor (vWF) and P- selectin, two adhesion proteins that can be rapidly mobilized to the cell surface by exocytosis in response to thrombin or other agonists. In this study, we attempted to identify additional components of Weibel- Palade bodies by raising monoclonal antibodies to these granules, purified by cell fractionation. One antibody, 2C6, was found to be specific for CD63, a membrane glycoprotein previously described in the lysosomes of platelets and other cell types. The immunopurified 2C6 antigen was recognized by an anti-CD63 reference antibody, 2.28, by Western blotting. Also, the biosynthetic profile of the 2C6 antigen in endothelial cells showed a nascent molecular mass and a glycosylation pattern identical to that of CD63. Immunofluorescence staining with 2C6 showed the lysosomes, and also elongated structures identified as Weibel-Palade bodies by their shape, ...
Severe sepsis/septic shock is a serious condition associated with high mortality rate. The pathophysiology of the disease involves the complex interaction between hosts immunity and the microorganisms toxin. The release of immune complex and cascade of inflammatory cytokines are responsible for multiorgan dysfunction, especially the cardiovascular system. Hydrocortisone has been recommended as a useful treatment to decrease mortality in hemodynamically unstable septic shock patients, not response to fluid and moderate dose of vasopressor. Both anti-inflammation and supplementation of relatively adrenal insufficiency are the main hypothesis of the benefit of hydrocortisone. During the progression of severe sepsis/septic shock, multi-organ dysfunction can develop. Acute lung injury (ALI) and its more severe form, acute respiratory syndrome (ARDS) is one of the common organ dysfunction associated with septic shock. Although there is controversy about timing and favorable patientscharacteristic, ...
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation with goal directed therapy help improving survival and outcome especially the resuscitation within the first 6 hours. In surgical patients, either severe sepsis/septic shock bought them to the operating room or this sepsis might be found after surgery resulting in higher morbidity and mortality. Not only knowledge management, others possible risk factors should also be identified and corrected for outcome improving. This prospective observational study will be done in 800 adult surgical patients admitting to the general surgical intensive care unit. Incidence of severe sepsis/septic shock on admission along with risk factors associated with poor outcomes [organ failure (AKI, ALI, PMI, liver failure, stroke), prolonged ICU length of, stay, ICU death] will be recorded especially effect of amount and type of fluid replacement in the ...
0011] vWF synthesized in megakaryocytes and endothelial cells is stored in platelet--granules and Weibel-Palade bodies, respectively, as ultra large vWF (UL-vWF) (Moake J L, Rudy C K, Troll J H, Weinstein M J, Colannino N M, Azocar J, Seder R H, Hong S L, Deykin D. Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N Engl J Med. 1982 ; 307:1432-1435; Wagner D D, Olmsted J B, Marder V J. Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol. 1982 ; 95:355-360; Wagner D D, Bonfanti R. von Willebrand factor and the endothelium. Mayo Clin Proc. 1991 ; 66:621-627; Sporn L A, Marder V J, Wagner D D. von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively. Blood. 1987 ; 69:1531-1534; Tsai H M, Nagel R L, Hatcher V B, Sussman, I I. Endothelial cell-derived high molecular weight von Willebrand factor ...
This caricaturing of science is confusing and misleading. "Breakthrough as scientists create first drug to halt Alzheimers disease," breathlessly reads one. "Betting study used monkey brains," cries another, this one fuelled by the activities of animal rights campaigners. Though not alone, animal research is a particularly frequent victim of the "black box effect." This is at least partly due to scientists reluctance to speak about animal research, ironically stemming from anxiety about misrepresentation of their work, or even possible retaliation from animal rights activists.. Science is not a string of groundbreaking discoveries communicated through press releases, tweets, and hurried mass emails. Rather, it is incremental, nuanced, and often contradictory. It is defined as much by its methods and their limitations as it is by its breakthroughs. For science communication to work, it has to embrace this complexity, bringing the scientific method, and its baggage, to the foreground.. In ...
TY - JOUR. T1 - Effect of Late-Onset Sepsis on Energy Expenditure in Extremely Premature Infants. AU - Torine, Ilana J.. AU - Denne, Scott C.. AU - Wright-Coltart, Shirley. AU - Leitch, Catherine. PY - 2007/5. Y1 - 2007/5. N2 - The purpose of this study was to compare total energy expenditure (TEE) in extremely premature infants during and after an episode of sepsis. We hypothesized that TEE in the sepsis group (SEP) would be higher during the septic period and higher than an age-matched control group (CTL). We further hypothesized that the TEE of the SEP group during the recovery period would be similar to that of the CTL group. The doubly labeled water method was used to determine TEE in both groups. Infant characteristics were as follows: SEP group, n = 10, gestation = 26 ± 1 wk, birth weight = 854 ± 218 g; CTL group, n = 10, gestation = 26 ± 1 wk, birth weight = 880 ± 158 g. TEE of the SEP group during the septic period was significantly greater than during the recovery period (96 ± 25 ...
The National Institutes of Health has named Thomas L. Brown, Ph.D., a Wright State University researcher investigating the causes of pregnancy-associated disorders leading to premature births, to its prestigious pregnancy study section that is instrumental in national biomedical research.. Brown, a professor and vice chair for research in the Department of Neuroscience, Cell Biology and Physiology, was appointed as a full member of the NIH Pregnancy and Neonatology Study Section, Center for Scientific Review from July 1, 2013, through June 30, 2019. Brown will review grant applications, make recommendations and survey the status of research.. "Selection to serve as a full member of the Pregnancy and Neonatology Study Section is a tremendous honor, as it highlights the national recognition and standing our research program in pregnancy-associated disorders has here at Wright State University," Brown said. "While serving as a study section member involves a substantial time commitment and a high ...
National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science ...
The National Academy of Future Physicians and Medical Scientists today announced Nobel Prize winner Dr. Mario R. Capecchi as its new Science Director.. Dr. Capecchi, a biophysicist, won the 2007 Nobel Prize in Physiology or Medicine for his work in finding ways to manipulate the mammalian genome by inserting new genes into cells. This research led to the breeding of "knock-out mice" and "knock-in mice," animals with a single gene removed or inserted.. Today Dr. Capecchi is a distinguished professor of human genetics at the University of Utah School of Medicine. His research interests include the molecular genetic analysis of early mouse development, neural development in mammals, the production of murine models of human genetic diseases, gene therapy, homologous recombination and programmed genomic rearrangements in mice. Dr. Capecchi has also received many awards and honors including the National Medal of Science (2001), the Lasker Award (2001), and the Wolf Prize in Medicine (2003).. The ...
Background Up to 50% of septic patients develop acute kidney injury (AKI). The pathomechanism of septic AKI is poorly understood. Therefore, we established an innovative rodent model to characterize sepsis-induced AKI by standardized colon ascendens stent peritonitis (sCASP). The model has a standardized focus of infection, an intensive care set up with monitoring of haemodynamics and oxygenation resulting in predictable impairment of renal function, AKI parameters as well as histopathology scoring. Methods Anaesthetized rats underwent the sCASP procedure, whereas sham animals were sham operated and control animals were just monitored invasively. Haemodynamic variables and blood gases were continuously measured. After 24 h, animals were reanesthetized; cardiac output (CO), inulin and PAH clearances were measured and later on kidneys were harvested; and creatinine, urea, cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) were analysed. Additional sCASP-treated animals were investigated
ISHS IV International Chestnut Symposium THE UNITED STATES NATIONAL SCIENCE FOUNDATION PROJECT ON DEVELOPING TOOLS FOR THE STUDY OF THE FAGACEAE: CASTANEA, QUERCUS, AND FAGUS
From the Society for Glycobiology ,http://www.glycobiology.org/, Please do not reply to this email - replies are assumed to be bounces & automatically deleted. If you need to contact the sender write to president at glycobiology.org ,mailto:president at glycobiology.org, _____ Dear Glycoscientist This is an update regarding the reorganization of the grant review structure at the National Institutes of Health ( http://www.csr.nih.gov/review/reorgact.asp). A new set of study sections have now been recommended that covers Cell Biology ( http://www.csr.nih.gov/PSBR/CB/CBIntro.htm): * Cell Physiology Study Section (CP) * Nuclear-Cytoplasmic Dynamics Study Section (NCD) * Extracellular Interactions Study Section (ECI) * Cell Structure and Function Study Section (CSF) * Cell Organization and Regulation Study Section (COR) For details please visit the societys website www.glycobiology.org ,http://www.glycobiology.org/, . Note that the only explicit mention of glycosylation is in the Description of ...
TY - JOUR. T1 - Patient Reported Outcomes Measurement Information System and Quality of Life in Neurological Disorders Measurement System to Evaluate Quality of Life for Children and Adolescents with Neurofibromatosis Type 1 Associated Plexiform Neurofibroma. AU - Lai, Jin Shei. AU - Jensen, Sally E.. AU - Charrow, Joel. AU - Listernick, Robert. PY - 2019/3. Y1 - 2019/3. N2 - Objective: To assess the health-related quality of life of children with neurofibromatosis type 1-related plexiform neurofibromas (pNF) using a battery of patient-reported outcome measures selected based on a conceptual framework derived from input by patients, parents, and clinicians regarding the most important pNF symptoms and concerns. Study design: There were 140 children with pNF ages 8-17 years who completed the Patient-Reported Outcomes Measurement Information System (including domains anxiety, depressive symptom, psychosocial stress experiences, fatigue, pain interference, meaning and purpose, positive affect, peer ...
Over the past 25 years, substantial progress has been made in the diagnosis and characterization of VWD, thanks mainly to advances in the genetic and molecular analysis of this common disease.2 However, understanding of the cellular defects of VWD has lagged behind because of the complexity of accessing the relevant cells from patients and the difficulties in establishing reliable in vitro models. Here we demonstrate that the study of ECs, the main source of plasma VWF,26 from patients with VWD, provides novel, important information on the pathogenesis of VWD and opens a new phase in the understanding of this complex disease.. BOECs (also called late outgrowth endothelial progenitor cells or endothelial colony-forming cells) are bone marrow-derived stem cells that have the ability to differentiate into mature ECs27 and have been implicated in postnatal vasculogenesis and endothelial repair at sites of endothelial damage.28 We have previously isolated BOECs from VWD patients5 and patients with ...
Sepsis is a serious infectious life threatening disease. In this study, we demonstrate that LII-34, a natural compound isolated from garlic (Allium sativum L.), markedly enhances survival rate, by inhibiting lung inflammation in cecal ligation and puncture (CLP) experimental polymicrobial sepsis model. LII-34 strongly reduced bacterial colony unit from peritoneal fluid in CLP mice by stimulating generation of reactive oxygen species. Lymphocyte apoptosis from spleen in CLP mice was also markedly decreased by LII-34 administration. LII-34 also significantly inhibits the production of proinflammatory cytokines such as TNF-α, interleukin-1β (IL-1β) and IL-6 in CLP mice. Lipopolysaccharide-stimulated the production of TNF-α, CCL2, IL-6, and IL-10 are also strongly inhibited by LII-34 in mouse bone marrow-derived macrophages. Taken together, our results indicate that LII-34 shows therapeutic effect against polymicrobial sepsis by enhancing microbial killing and blocking cytokine storm. Chang Youp ...
Both questionnaires showed high reliability across items and validity with respect to clinical markers of eye disease. Future research should compare the properties of these shortened surveys with those of the NEI VFQ-25.
LAWRENCE - More than 800 students, faculty, staff, and guests attended KUs 22nd annual Undergraduate Research Symposium on April 27 to hear student presenters share the results of their research and creative projects. The event took place in the Kansas Union and the Commons, where over 300 students from across campus presented their projects. "We were impressed by the number of students who chose to share their research and creative endeavors with the campus and community at the Undergraduate Research Symposium this year, as well as the quality of the work they were presenting," said Alison Olcott, director of the Center for Undergraduate Research and associate professor of geology.. Student presenters prepared for the symposium by attending workshops with staff from the Center for Undergraduate Research and working closely with their research mentors to refine their oral presentations, poster presentations and artists talks. KUs Undergraduate Research Symposium is sponsored by the Center for ...
TRANSITIONAL CAREER DEVELOPMENT AWARD IN WOMENS HEALTH RESEARCH Release Date: January 14, 2000 RFA NUMBER: OD-00-003 National Institute on Aging National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute of Dental and Craniofacial Research National Institute on Drug Abuse National Institute of Environmental Health Sciences National Heart, Lung, and Blood Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research Office of Research on Womens Health Foundation for the National Institutes of Health Pfizer Womens Health, Pfizer Inc National Foundation for Biomedical Research PURPOSE The NIH Office of Research on Womens Health (ORWH) invites applications for the Transitional Career Development Award in Womens Health Research. This award is designed to ...
NATIONAL INSTITUTE ON AGING: PILOT RESEARCH GRANT PROGRAM Release Date: January 9, 1998 PA NUMBER: PAR-98-021 P.T. National Institute on Aging Application Receipt Dates: March 17, 1998; July 17, 1998; November 17, 1998 PURPOSE The National Institute on Aging (NIA) is seeking small grant (R03) applications in specific areas to: (1) stimulate and facilitate the entry of promising new investigators into aging research, or (2) encourage established investigators to enter new targeted, high priority areas in this research field. This Small Grant (R03) Program provides support for pilot research that is likely to lead to a subsequent individual research project grant (R01) and /or a significant advancement of aging research. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Program Announcement (PA), National Institute on Aging: Pilot ...
More than 150 students from 10 South Florida high schools throughout Miami-Dade and Broward counties participated once again in Barry Universitys Department of Physical Sciences 12th annual Chemistry and Physics Tournament.. The competition, formerly known as the Science Olympiad, was held in different laboratories throughout campus on April 19. The one-day event is a high school science academic competition in chemistry and physics in which students compete in written tests, oral competitions and lab activities.. The Science Tournament is the Department of Physical Sciences outreach program to high school students in support of the pursuit of excellence in science education. Students broke out in teams and competed throughout the day for various awards and recognitions, including a $1,000 scholarship from Barry.. One of the primary goals of the Science Tournament is to highlight the achievements of outstanding science students and increase the opportunities for female and minority students ...
MANHATTAN - A recently hired veterinary pathologist is bringing multiple skills to her new position in the College of Veterinary Medicine at Kansas State University, including experience with a human primary cell line used for modeling human influenza infections. A. Sally Davis is an assistant professor of experimental pathology in the diagnostic medicine and pathobiology department. Part of her appointment at Kansas State University is to provide pathology support to the Department of Homeland Securitys Center of Excellence for Emerging Zoonotic Animal Diseases at the university. Davis graduated in 2014 from the National Institutes of Health Comparative Biomedical Scientist Training Program in partnership with North Carolina State University. At the NIH, she conducted her doctoral research under Dr. Jeffery K. Taubenberger in the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Diseases. Her work was funded through the Intramural Research Program of the ...
Hassan Azzazy is a tenured professor of Chemistry (2003-present) at The American University in Cairo (AUC). He serves as the Chairman of Chemistry Department and was the Associate Dean for Graduate Studies and Research at the School of Sciences and Engineering, AUC. He is the founder of the Novel Diagnostics & Therapeutics Research group and the director of the International Medical Laboratory Scientists training program at AUC.
Several systemic diseases including thrombotic thrombocytopenic purpura manifest much of their pathology through activation of endothelium and thrombotic occlusion of small blood vessels often leading to multi-organ failure and death. bind platelets leukocytes and erythrocytes obstructing blood flow and sometimes shearing passing erythrocytes. Our findings uncover the biophysical requirements for initiating microvascular thrombosis and suggest mechanisms for the onset and progression of microvascular diseases. von Willebrand factor (VWF) a very large multimeric blood protein has a pivotal role in initiating haemostasis and thrombosis and has emerged as an important risk factor and therapeutic target for many vascular diseases1 2 3 4 VWF is usually primarily secreted from your endothelium either constitutively or in a regulated fashion from Weibel-Palade body after endothelial activation5 6 Much of the secreted VWF remains bound to the endothelial surface until it is proteolytically removed by ...
TY - JOUR. T1 - Purpura fulminans and late onset group B streptococcal sepsis in a premature twin. AU - Elayappen, Avanikkha. AU - Jain, Sunil K.. AU - Loeffelholz, Michael J.. AU - Patel, Janak. PY - 2014/5/12. Y1 - 2014/5/12. N2 - Introduction: Purpura fulminans (PF) is a skin manifestation due to hemorrhagic infarction caused by intravascular thrombosis secondary to bacterial infections or deficiency of anticoagulants such as protein C and protein S. Neonatal PF is a rare but potentially disabling disorder associated with a high mortality and severe long term morbidity in those who survive. Case description: We report a case of a premature infant who developed extensive PF due to late onset group B streptococcus sepsis. Despite early identification and initiation of antibiotic therapy in our patient, PF progressed rapidly, leading to autoamputation of fingers and toes and severe brain injury. Conclusion: In conclusion, our case highlights the severe sequelae of PF due to late onset GBS sepsis ...
To describe the first experiences on the use of protein C concentrate (PC) in adult patients with severe sepsis and septic shock and clinical contraindications to activated protein C (APC). On the basis of the effectiveness demonstrated by the activated form in sepsis and of the encouraging results expressed in the literature of PC mainly about meningococcus fulminating infections, we carried out an observational study on PC with 28-day follow-up and a daily analysis of the hematochemical and clinical parameters. Particular attention was paid to the variations in the PC plasma levels, to the modifications of the coagulation system, to the SOFA score as well as to the safety under bleeding risk conditions. The study included 10 patients (seven females and three males) either with severe sepsis (four patients) or septic shock (six patients); one of them had DIC, with PC plasma levels less than 50%. APC could not be administered because of clinical reasons. Patients mean age was 63.5 years ...
International Space Station Science Office. Link to Story at NASA: http://www.nasa.gov/mission_pages/station/research/news/ssep_conference/. Every so often, doomsayers arise to decry the state of Americas scientific community, fearing that its future is endangered because of a lack of bright new talent. But its easy to find a powerful counterargument to that gloomy view. Every July at the National Air & Space Museum in Washington, the next generation of Americas space scientists-students from 5th grade up to college age-share their work with each other, the scientific community and the public at the Student Spaceflight Experiment Program (SSEP) annual conference.. Since June 2010, the National Center for Earth and Space Science Education (NCESSE) SSEP effort, in partnership with NanoRacks LLC under a Space Act agreement, has offered young scientists the opportunity for the ultimate science fair project: conceiving, designing, implementing and analyzing a real scientific research question in ...
Whenever social scientists ask a question in a book title, especially a question about the power of science to achieve something, the answer is obviously "No." Indeed, we do not have to wait long before the suspense is lifted. Margaret Lock and Gisli Palsson answer the question Can Science Resolve the Nature/Nurture Debate? with "The position we take is that science cannot resolve nature/nurture debates. In effect, such debates are a red herring because nature and nurture are not readily demarcated objects of scientific inquiry" (p. 10). At the end of the book, the authors add that such debates should not be resolved. The book, however, is not a red herring. Lock and Palsson take stock of developments in the science of epigenetics, and, to a lesser extent, in the overlapping field of the microbiome. These developments follow the disappointment with genetic deterministic thinking during the 20th and beginning of the 21st century and offer an opportunity to think through the role of nurture at the ...
The UB-led consortium that won a prestigious $15 million Clinical and Translational Science Award from the National Institutes of Health in 2015 has adopted a new name and visual identity that better represent the work in which its members are engaged.. In an effort to more accurately reflect its collaborative and scientific missions, the new entity will be called the University at Buffalo Clinical and Translational Science Institute (CTSI). Under this new name, the CTSIs collaborative partners demonstrate their shared commitment to improving health and reducing health disparities in the Buffalo Niagara region by conducting and supporting research that leads to new, innovative medical therapies and technologies, and working to make them widely available to the community. The CTSIs new logo features the UB logo and is consistent with the new brand and identity strategy launched by the university in 2016.. "The change in our name to the Clinical and Translational Science Institute is a better ...
Mortality rates from acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) range from 38.5 to 65%, with the lower mortality in acute lung injury than in ARDS.. ARDS/ALI is most often seen as part of a systemic inflammatory response syndrome (SIRS), particularly systemic sepsis. The lung findings parallel the damage in other tissues, namely, widespread destruction of the capillary endothelium, extravasation of protein rich fluid and interstitial edema. The alveolar basement membrane becomes damaged and fluid leaks into the airspaces, reducing lung compliance and causing ventilation-perfusion mismatch.. The most important causes of ALI/ARDS are sepsis, pneumonia, major trauma, pulmonary aspiration, near drowning, burns, inhalation of toxic gases (e.g. ammonia), fat embolism, amniotic fluid embolism, eclampsia, drug intoxication (e.g. aspirin), radiation injury and mechanical ventilation. Cox and colleagues have demonstrated in an ovine model of ARDS that there is intense acute ...
Background-Pulmonary arterial hypertension (PAH) is characterized by abnormal growth and enhanced glycolysis of pulmonary artery endothelial cells (PAECs). However, the mechanisms underlying alterations in energy production have not been identified. Methods-Here, we examined the miRNA and proteomic profiles of blood outgrowth endothelial cells (BOECs) from patients with heritable PAH (HPAH) due to mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene and patients with idiopathic PAH (IPAH) to determine mechanisms underlying abnormal endothelial glycolysis. We hypothesized that in BOECs from PAH patients, the downregulation of miR-124, determined using a tiered systems biology approach, is responsible for increased expression of the splicing factor polypyrimidine-tract-binding protein (PTBP1), resulting in alternative splicing of pyruvate kinase muscle isoforms 1 and 2 (PKM1 and 2) and consequently, increased PKM2 expression. We questioned whether this alternative regulation ...
Purpura fulminans due to sepsis is a hematologic emergency characterized by disseminated intravascular coagulation (DIC), skin necrosis, and multiorgan dysfunction.1 It may be caused by severe bacterial infection, most often gram-negative sepsis, or other infections. The organism most commonly implicated in pediatric patients is Neisseria meningitidis (>90%), followed by Streptococcus pneumoniae and group A and B streptococci.2,3 Most cases of Staphylococcus aureus sepsis are reported as toxic shock syndrome. Outbreaks occur in semi-closed communities, such as child care centers, college dormitories, and military bases. Transmission occurs by direct contact with secretions or fomites carrying the offending organism. ...
DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM NATIONAL INSTITUTE ON DRUG ABUSE AGENDA Second Joint Meeting of the NATIONAL ADVISORY COUNCIL ON ALCOHOL ABUSE AND ALCOHOLISM, NATIONAL ADVISORY COUNCIL ON DRUG ABUSE, AND NATIONAL CANCER ADVISORY BOARDFebruary 5, 2014
[email protected] About the National Institute on Drug Abuse (NIDA): The National Institute on Drug Abuse (NIDA) is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports most of the worlds research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. Fact sheets on the health effects of drugs and information on NIDA research and other activities can be found at www.drugabuse.gov, which is now compatible with your smartphone, iPad or tablet. To order publications in English or Spanish, call NIDAs DrugPubs research dissemination center at 1-877-NIDA-NIH or 240-645-0228 (TDD) or email requests to [email protected] Online ordering is available at drugpubs.drugabuse.gov. NIDAs media guide can be found at www.drugabuse.gov/publications/media-guide/dear-journalist, and its easy-to-read website can be found at ...
The integrity of the vascular barrier, which is essential to blood vessel homoeostasis, can be disrupted by a variety of soluble permeability factors during sepsis. Pigment epithelium-derived factor (PEDF), a potent endogenous anti-angiogenic molecule, is significantly increased in sepsis, but its role in endothelial dysfunction has not been defined. To assess the role of PEDF in the vasculature, we evaluated the effects of exogenous PEDF in vivo using a mouse model of cecal ligation and puncture (CLP)-induced sepsis and in vitro using human dermal microvascular endothelial cells (HDMECs). In addition, PEDF was inhibited using a PEDF-monoclonal antibody (PEDF-mAb) or recombinant lentivirus vectors targeting PEDF receptors, including adipose triglyceride lipase (ATGL) and laminin receptor (LR). Our results showed that exogenous PEDF induced vascular hyperpermeability, as measured by extravasation of Evans Blue (EB), dextran and microspheres in the skin, blood, trachea and cremaster muscle, both ...
Sid is a freelance science writer based in Crossville, Tenn. He specializes in earth sciences and paleontology but often tackles topics such as astronomy, planetary sciences, materials sciences and engineering. Sid has a bachelors degree in Natural Science from Christian Brothers College (Memphis, Tenn.), bachelors and masters degrees in aeronautical engineering from the Air Force Institute of Technology, and a masters degree in journalism from the University of Missouri in Columbia.. In 2009, Sid won the Award for Distinguished Science Journalism in the Atmospheric and Related Sciences from the American Meteorological Society. And in 2002, he was co-winner of the American Astronomical Societys Solar Physics Divisions Award for Popular Writing on Solar Physics. Sids writing also appears in Nature, Scientific American, Science News and Science News for Kids. He often appears on The John Batchelor Show, a syndicated radio program, to discuss the research he has written about.. ...
Certified Organic SuperFruit Antioxidant Juice Organic Mangosteen Juice, Goji Juice and other juice concentrates Naturally Rich in Xanthones A Dietary Supplement Vegetarian Product Genuine Whole Food The Mangosteen (Garcinia mangostana) Fruit has been treasured for thousands of years by the people living in Southeast Asia. Also known as the Queen of Fruits, the Mangosteen has been used traditionally for its numerous health benefits. More recently, scientific inquiry has revealed the extraordinary properties of the Mangosteen and its rich supply of antioxidants called Xanthones. Antioxidant Protection The Mangosteen fruit contains a number of Xanthones and Proanthocyanidins. These powerful antioxidants help to neutralize and eliminate free radicals, and thus support healthy cellular function. NOW Mangosteen SuperFruit Antioxidant Juice also contains Goji Juice, and concentrates of Pomegranate, Blueberry, Cranberry, and Black Cherry which boost the ORAC value to over 19,000 per
Results Most common blood culture isolates in decreasing order of frequency were Klebsiella (42.4%), Coagulase Negative Staphylococci (11.2%), Enterobacter (9.4%), Escherichia coli (9.1%), Pseudomonas (5.4%) and Acinetobacter (4.7%). Gram negative organisms were predominant in early and late onset neonatal sepsis as well as in inborn and outborn babies. Staphylococcus aureus and Enterococci were uncommon. Candida species were isolated in early onset sepsis and in babies weighing more than 1500 gm. Most gram negative organisms were resistant to ampicillin, gentamicin and cephalosporins. Sensitivity of amikacin, levofloxacin and piperacillin-tazobactam against Gram negative organisms ranged from 25% to 75%. Incidence of Methicillin Resistant Staphylococcus Aureus and Vancomycin resistant Enterococci was 33% and 20% respectively. Most Candida isolates were sensitive to antifungals. The most effective first line antibiotic combinations were amikacin with levofloxacin and amikacin with ...
This is the official website of Razi Journal of Medical Sciences published by Tehran University of Medical Sciences.The Razi Journal of Medical Sciences (RJMS) is the scientific medical journal of Iran, which has been published from 1993 onward in Persian with abstract of English language (former Journal of Iran University of Medical Sciences). Although it had been published quarterly in the past, RJMS has been published monthly (12 issues per year) from the year 2009. The Razi Journal of Medical Sciences, a scientific and research peer reviewed journal, seeks to publish original papers, selected review articles and case reports. RJMS also seeks to provide its readers with the highest quality materials published through a process of careful double-blind peer reviews and editorial comments. RJMS is an official publication of the Tehran University of Medical Sciences.
This unit aims to equip science and medical graduates with an in-depth knowledge of medical mycology and parasitology that will enable them to work effectively as laboratory personnel, clincians and medical scientists in relevant hospital laboratories, clinics or research institutions. The course will allow students to develop skills in recognising fungal and parasitic infections, interpret laboraroty reports on identifictaion of the mycotic and parasitic disease agents and molecular typing of clincial isolates, evaluation of scientific literature, in problem-solving and in scientific communication that will enable graduates to develop careers as microbiologists, clinicians and administrators or policy-makers in hospitals, health care organizations or government bodies. The course structure involves lectures on diseases caused by fungal, protozoan and helminthic agents, laboratory classes on identification of fungal and parasitic infections (classical methods such as morphology and biochemistry, ...
What happens when two systems, law and medicine, are joined in the arena of the court? This work deals with the structure and the premises of two diverse discourse models; the approach is anthropological. Several chapters are preponderantly based on legal research, addressing cases requiring testimony by expert witnesses on recent technologies used in the laboratories of medical scientistS Descriptions of other societies and cultures consider the identical problems of rights, privileges, and duties, and provide perspectives to cultural self-knowledge. This volume can be used as a text for courses taught in medical schools and law schoolS It will be of particular interest to students taking courses in health science, public health, medical anthropology, forensic anthropology, psychology, sociology, public justice, behavioral sciences, forensic psychiatry, legal anthropology, social welfare, as well as courses on research modelS
Mycophenolic acid, less accurately called mycophenolate, is an immunosuppressant drug used to prevent rejection in organ transplantation. It was initially marketed as the prodrug mycophenolate mofetil (MMF) to improve oral bioavailability. More recently, the salt mycophenolate sodium has also been introduced. Mycophenolate mofetil is marketed under the trade name CellCept and mycophenolate sodium as Myfortic. Discovered by an Italian medical scientist Bartolomeo Gosio in 1893, mycophenolic acid was the first antibiotic to be synthesised in pure and crystalline form. But its medical application was forgotten until two American scientists C.L. Alsberg and O.M. Black resynthesised it in 1912, and gave its chemical name. It was eventually found to be a broad-spectrum acting drug having antiviral, antifungal, antibacterial, anticancer, and antipsoriasis properties. The clinically usable drug Cellcept was developed by South African geneticist Anthony Allison and his wife Elsie M. Eugui. It was first ...
This caught my eye because the only prescription migraine preventive thats ever helped me is cyproheptadine, an antihistamine. And physicians dont know exactly why it helps with migraine. Furthermore, my head often hurts worse after I eat, no matter the food - a phenomenon no doctor of any specialty has been able to explain to me. This pieces came together when I learned that that some foods contain histamine, that others cause histamine to be released in the body, and that the body releases histamine as part of digestion?. Researching histamine intolerance led me to discover that some people have a sensitivity to salicylate, a naturally occurring food chemical. More light bulbs turned on when I discovered that corn and olive oil, both of which have triggered migraines for me, are high in salicylates, as are some of my favorite vegetables. Vegetables that I have been consuming in mass quantities since starting the migraine diet.. There is so much to tell you and so much I have yet to learn and ...
Scientists believe that endorphins and pain are connected because the body releases endorphins to help combat the effects of physical pain and stress. These neurotransmitters have an effect on the brain that is often compared to that of morphine or other opiate drugs, in that endorphins and opiate drugs affect the same receptors in the brain. Endorphins and pain are connected because pain can cause the release of endorphins in the brain, but other activities are also believed to release endorphins. Laughter, physical contact with loved ones, sex, childbirth, strenuous exercise, and eating certain foods are also believed to cause the release of endorphins. Experts believe that endorphins can help people bond with one another, overcome physical and mental fatigue, and cope with extreme pain ...
Picture a gas tanker, the type that delivers gas to a gas station. The tanker has a small tank that it uses like any other vehicle, and in theory it could run out just like any other vehicle. The irony is the large tank containing the payload for the gas station could still be full. In this analogy, the gas in the small tank that fuels the tanker is glycogen, the storage form of glucose (sugar). The large payload tank is fat stored in adipose tissue. Becoming fat-adapted then is like modifying the gas tanker so that it can use all of the fuel on board. The range of the vehicle is almost without limits.. As the name suggests, hormone-sensitive lipase is an enzyme whose function is inhibited by the hormone insulin. In order to get access to the fat stored in adipose tissue, insulin must be kept low. Your body releases insulin in response to consuming sugar. Whats the first thing that everybody does before starting a race? Shut down fat-burning by consuming a sugary gel! As anyone who has tried to ...
This is all about avoiding success after recurrent pregnancy loss time that your body releases eggs from your ovaries, which normally happens in the middle of your pregnxncy. The main sources for this hub are the United States Department of Agriculture (USDA) Nutrition Program and WebMd. Though Prwgnancy think at 41 years of age, I can hang up the pram. Being a mother is truly a rewarding journey; pregnncy, trials and hardships can never be avoided as they are inevitable. and Zoosk, for example, offer mobile dating where you can log in securely from your smartphone. It may help kids that are suffering in foster homes and recurrrent that they are forgotten. You could also start your own family-oriented social group by inviting all your single-parent friends and their children to some event, such as a picnic or a day at the zoo. Headaches are the result of increased blood circulation caused by pregnancy hormones. Theres the option of displaying onscreen notices, or suspending play when these ...
Trauma can change us. Even small traumas: a car accident, a confrontation, death of a loved one; can alter our hormones and neurotransmitters, our digestion, our pain. We may notice dreams, intrusive thoughts, headaches, stomach aches, have trouble thinking clearly after such an event. But usually, in time, thoughts of the event fade and our bodies release hormones for restoration and recovery and we return to normal.. But what happens if that trauma is severe or prolonged or repeated such as in war, rape, domestic violence or a natural disaster? It alters our brains. Switches us into survival mode. Stress hormones are released that change our hormones and our neurotransmitters. These hormones affect our relationships, sleep, moods and cause physical symptoms such as headaches, stomach aches, fatigue and increased risks of infection. This is known as Post traumatic Stress Disorder or PTSD.. The main symptoms of PTSD are intrusive thoughts, mood alterations, exaggerated startle response and ...
The short-term survival following acute myocardial infarction: A prospective observational study Journal Article published 1 Mar 2017 in Journal of Basic Research in Medical Sciences volume 4 issue 2 on pages 9 to 16 Authors: Mohammad Aryaie, Health Management and Social Development Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Fozieh Bakhsha, Seyyed Yaghub Jafari, Zahra Yousefi, Ali Reza Heidari, Zahra Esmaeili, Sakineh Sobhani, Shima Aghili, Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran , Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran , Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran , Health Management and Social Development Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Research Committee, Golestan University of Medical Science, Gorgan, Iran, Research Committee, Golestan University of Medical Science, Gorgan, ...