Clinical Trials - clinicaltrials.gov Primary Objective: Evaluation of the - Carriage rate of Streptococcus pneumoniae in the nasopharynx of children Secondary O...
Jeremy Keenan and colleagues report that during a cluster-randomized clinical trial in Ethiopia, nasopharyngeal pneumococcal resistance to macrolides was significantly higher in communities randomized to receive azithromycin compared with untreated control communities.
We collected nasopharyngeal specimens from 1011 children, 290 (29%) of whom were colonized with pneumococcus. Non-PCV7 serotypes accounted for 98% of pneumococcal isolates, most commonly 19A (14%), 6C (11%), and 15B/C (11%). In 2008-2009, newly targeted PCV13 serotypes accounted for 20% of carriage isolates and 41% of penicillin-nonsusceptible S. pneumoniae. In multivariate models, younger age, child care, young siblings, and upper respiratory illness remained predictors of pneumococcal carriage, despite near-complete serotype replacement. Only young age and child care were significantly associated with penicillin-nonsusceptible S. pneumoniae carriage. ...
Define nasopharynx. nasopharynx synonyms, nasopharynx pronunciation, nasopharynx translation, English dictionary definition of nasopharynx. n. pl. na·so·pha·ryn·ges or na·so·phar·ynx·es The part of the pharynx above the soft palate that is continuous with the nasal passages. na′so·pha·ryn′ge·al...
Nasopharyngeal culture is a test that examines a sample of secretions from the uppermost part of the throat and behind the nose. Learn more about this test.
The role of phase variation of lic1A, lic2A and lic3A in the ability of Haemophilus influenzae type b to colonize the nasopharynx, bloodstream and cerebrospinal fluid (CSF) of infants was investigated. This was achieved by using PCR to determine the number of 5′-CAAT-3′ repeats present in each gene, which is indicative of whether each ORF can be expressed. Multiple PCR products of different intensities were amplified from all three genes at each site sampled. This indicated that the nasopharynx, bloodstream and CSF were colonized by a heterogeneous population of organisms, expressing different combinations of lic genes. At each site however, a predominant PCR product was amplified from each gene, indicating that organisms with this genotype were the most abundant. The number of 5′-CAAT-3′ repeats in this predominant product varied depending upon whether organisms were isolated from the nasopharynx, bloodstream or CSF. These observations suggest that the expression of different combinations of
Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We previously reported that intranasal immunization of mice with pneumococci confers CD4+ T cell-dependent, antibody- and serotype-independent protection against colonization. Here we show that this immunity, rather than preventing initiation of carriage, accelerates clearance over several days, accompanied by neutrophilic infiltration of the nasopharyngeal mucosa. Adoptive transfer of immune CD4+ T cells was sufficient to confer immunity to naïve RAG1 -/- mice. A critical role of interleukin (IL)-17A was demonstrated: mice lacking interferon-γ or IL-4 were protected, but not mice lacking IL-17A receptor or mice with neutrophil depletion. In vitro expression of IL-17A in response to pneumococci was assayed: lymphoid tissue from vaccinated mice expressed significantly more IL-17A than ...
The nasopharynx is, by definition, the upper part of the throat behind the nose. It is a part of the pharynx, which comprises three separate segments: the nasopharynx, oropharynx, and the hypopharynx.
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Background. Lower respiratory tract infection (LRTI) is the leading cause of childhood deaths in most developing countries and the world (?) and are the most common causes of hospital and out-patient visits within the EU, comprising 1 of 3 admissions annually. In general, the over-prescription and use of broad-spectrum antibiotics are common practices that lead to the evolution and development of resistance in infectious bacteria and will lead to loss of time and resources in patient handling and adverse patient outcomes. Conventional approaches have depended upon cultivation of bacteria with subsequent testing for antibiotic sensitivity. Therefore, reliable and time-effective microbiological diagnostics are essential for more effective treatment of respiratory infections. In this project, we apply state-of-the-art proteomics techniques for identifications of pathogens and antibiotic resistance from clinical samples, without prior cultivation. Material and methods. Nasopharyngeal swab samples ...
The nasopharynx, the upper area of the throat behind the nose, is the space above the soft part of the roof of the mouth that allows the passage of air from the nose to the throat, according to...
The Annals of Nasopharynx Cancer publishes research articles on epidemiology, chemoprevention and screening, clinical management, translational and experimental research specific.
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Sensory pillsdiscountrx ru and motor neurons (nerve cells) micards without perscription from the forebrain and midbrain travel through the medulla. I went from a regular married working mom to micards without perscription now a single stay at home supermom. Some who are genetically predisposed may experience acid reflux regardless of what they do. You can find out in advance about your hospital or birthing center's policy, but plan to bring a few items for your baby anyway: Although it is expensive and its effectiveness varies depending on the infecting genotype of hepatitis C, it can provide more efficient, effective treatment and fewer side effects for many patients. It affects an individual's ability to concentrate, and may result in behavioral problems, such as: Thanks, Jeff -- can't wait to see you at the Innovation Summit and hear what you think about all this emerging diabetes tech. A nasopharyngeal culture is a quick, painless test used to diagnose upper respiratory ...
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There is growing concern that interventions that alter microbial ecology can adversely affect health. We characterised the impact of the seven-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal carriage and the bacterial component of the nasopharyngeal microbiome during infancy. Newborns were recruited into three groups as follows: Group1 (n = 33) was the control group and comprised infants who received PCV7 after 6 months and came from unvaccinated communities. Group 2 (n = 30) came from unvaccinated communities and Group 3 (n = 39) came from vaccinated communities. Both group 2 and 3 received PCV7 at 2, 3 and 4 months. Culture and 16 S rRNA gene sequencing were performed on nasopharyngeal specimens collected at regular intervals from infants. Nasopharyngeal carriage of PCV7 serotypes in Group 1 was significantly higher than in Group 2 and 3 (p | 0.01). However, pneumococcal carriage remained comparable due to an expansion of non-vaccine serotypes in Groups 2 and 3. Determination of
OBJECTIVE To compare percentages of mast cells in lymph node (LN) aspirate samples from clinically normal dogs, dogs with allergic dermatologic disease (ADD), and dogs with cutaneous mast cell tumors (MCTs). DESIGN Prospective cross-sectional study. ANIMALS 20 healthy dogs (group 1), 20 dogs with ADD (group 2), and 20 dogs with an MCT on the head or limbs (group 3). PROCEDURES LN aspirate samples were obtained from easily accessible LNs in group 1, affected skin regions in group 2, and the likely draining LN or LNs of the MCT in group 3; the percentage of mast cells was manually determined for each LN. For group 3, LNs were cytologically categorized with a modified version of a published metastasis categorization scheme. RESULTS Median (range) percentage of mast cells in aspirate samples was 0% (0% to 0.1%) for group 1, 0.05% (0% to 0.55%) for group 2, and 0.4% (0% to 77.4%) for group 3. In group 3, 16 LNs (13 dogs) were palpably normal in size; 6 of these had evidence of possible or certain metastasis.
Boyaka PN, Wright PF, Marinaro M, Kiyono H, Johnson JE, Gonzales RA, Ikizler MR, Werkhaven JA, Jackson RJ, Fujihashi K, Di Fabio S, Staats HF, McGhee JR. 2000. Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am J Pathol. 157(6):2023-35 ...
Nasopharynx surface, animated coloured scanning electron micrograph (SEM). Seen here are: squamous nasal epithelial cells, a ciliated nasal epithelial cell and an M cell (lymphoepithelium). The nasopharynx lies behind the nose and above the level of the soft palate. Stratified squamous nasal epithelial cells line the surface of the nasopharynx (tightly packed together in this image). The epithelial cell surfaces are covered with microvilli that increase the cell surface area. Mucus, secreted by cells in the epithelial lining (not seen), traps foreign objects, preventing them from entering the lungs. Near the centre of the image is a ciliated nasal epithelial cell. They have hair-like structures known as cilia. Coordinated, beating of the cilia propels the mucus to the back of the pharynx, where it is swallowed. The M-cell is part of the lymphoepithelium and aids in transporting foreign antigens to the underlying lymphoid follicles. Magnification: x1, 200 ...
Background: Streptococcus pneumoniae (the pneumococcus) remains a leading cause of infectious mortality worldwide. Acquisition of the pneumococcus occurs at the nasopharyngeal mucosa and elicits a rapid influx of neutrophils (PMNs) to the nasal lumen. However, the pneumococcus efficiently eludes clearance by PMNs and persists in the nasopharynx weeks after the acute inflammatory response recedes, amplifying the risk of invasive disease. A growing number of studies implicate the secreted phospholipid platelet-activating factor (PAF) as an important local mediator of PMN recruitment and activation in response to mucosal infections. While the pneumococcus has been shown to secrete a cell wall-bound esterase, Pce, which efficiently hydrolyzes PAF in vitro, it remains unknown whether regulation of local PAF concentration influences pneumococcal survival during colonization. Methods: We make use of atraumatic colonization of the murine nasopharynx to model carriage in the human upper respiratory ...
The purpose of this study is to assess the indirect effects of a pneumococcal conjugate vaccine administered to infants on vaccinees elder non-vaccinated siblings aged 3 to 7 years.. This study includes a cross-sectional sampling of nasopharyngeal and oropharyngeal swabs in 2011 and a register-based follow-up study for invasive disease, hospital-diagnosed pneumonia, tympanostomy tube surgery and outpatient antimicrobial treatment. ...
Background Indigenous children in Australia and Alaska have very high rates of chronic suppurative lung disease (CSLD)/bronchiectasis. Antibiotics, including frequent or long-term azithromycin in Australia and short-term beta-lactam therapy in both countries, are often prescribed to treat these patients. In the Bronchiectasis Observational Study we examined over several years the nasopharyngeal carriage and antibiotic resistance of respiratory bacteria in these two PCV7-vaccinated populations. Methods Indigenous children aged 0.5-8.9 years with CSLD/bronchiectasis from remote Australia (n = 79) and Alaska (n = 41) were enrolled in a prospective cohort study during 2004-8. At scheduled study visits until 2010 antibiotic use in the preceding 2-weeks was recorded and nasopharyngeal swabs collected for culture and antimicrobial susceptibility testing. Analysis of respiratory bacterial carriage and antibiotic resistance was by baseline and final swabs, and total swabs by year. Results Streptococcus
The study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex PCR from the nasopharynx of clinically septic patients during a winter season. During 11 weeks of the influenza epidemic period in January-March 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex PCR for respiratory viruses on the nasopharyngeal specimen. The results were compared with those from microbiology analyses ordered as part of standard care. During the winter season, viral respiratory pathogens, mainly influenza A virus, human metapneumovirus, coronavirus, and respiratory syncytial virus were clinically underdiagnosed in 70% of patients positive by the multiplex PCR assay. During the first four weeks of the influenza epidemic, few tests for influenza were ordered by clinicians, indicating low awareness that the epidemic had started. Nasopharyngeal findings of Streptococcus pneumoniae and Haemophilus ...
Nasopharyngeal Pneumococcal Carriage among Healthy Children in Cyprus Post Widespread Simultaneous Implementation of PCV10 and PCV13 Vaccines. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Matrix metalloproteinases (MMPs) play an important role in respiratory inflammatory diseases, such as asthma and chronic obstructive pulmonary disease. It was hypothesized that MMP-8 and MMP-9 may function as biological markers to assess disease severity in viral lower respiratory tract infections in children. MMP-8 and MMP-9 mRNA expression levels in peripheral blood mononuclear cells (PBMCs) and granulocytes obtained in both the acute and recovery phase from 153 children with mild, moderate, and severe viral lower respiratory tract infections were determined using real-time PCR. In addition, MMP-8 and MMP-9 concentrations in blood and nasopharyngeal specimens were determined during acute mild, moderate, and severe infection, and after recovery using ELISA. Furthermore, PBMCs and neutrophils obtained from healthy volunteers were stimulated with RSV, LPS (TLR4 agonist), and Pam3Cys (TLR2 agonist) in vitro. Disease severity of viral lower respiratory tract infections in children is associated ...
Hello,. Im 35 years old man with nasopharyngeal carcinoma. I just finish my treatment,35 radiation and 5 chemo+5 FU. I just receive my MRI report and it is very confusing,looks like there is some cancer cell left or other part of my left side of my nose. Now i have no idea what will be next since i finish the regular treatment! there is anyone here who took any different type of treatment? or anyone can explain me in summary my mri report?? it will be a big help,,. i have an appointement next week with the surgeon,,,,to remove the the lymphnode???? i no idea..... this is my MRI report,Thanks There has been interval improvement in disease involvement of the the nasopharyngeal mucosa with persisting signal abnormality in the basisphenoid and mild thickening of nasopharyngeal tissues. There is however,now T2. Hypointense tissue extending along the left aspect of the nasal septum and abnormal soft tissue extends interiorly along the medial wall of the nasal cavity and the inner aspect of the left ...
Paraffin embedded sections are provided from a wide variety of tissue sources from human, mouse, rat, monkey, dog, cat, rabbit, guinea pig, hamster, pig, bovine, sheep, chicken and equine. All the tissues are examined by qualified histologists to ensure that the sections are the best representation of the subject tissue. The tissue sections are suitable for in situ hybridization, immunolocalization, and laser capture microdissection (LCM ...
Nasopharyngeal cancer is a rare type of head and neck cancer in which malignant (cancer) cells form in the tissues of the nasopharynx. The nasopharynx is the upper part of the pharynx (throat) behind the nose. The pharynx is a hollow tube about 5 inches long that starts behind the nose and ends at the top of the trachea (windpipe) and esophagus (the tube that goes from the throat to the stomach). Air and food pass through the pharynx on the way to the trachea or the esophagus. The nostrils lead into the nasopharynx. An opening on each side of the nasopharynx leads into an ear. Nasopharyngeal cancer most commonly starts in the squamous cells that line the nasopharynx. See Head and Neck Cancers for signs, symptoms and treatments.. ...
From the foregoing experiments it appears that with the filtered nasopharyngeal secretions from early cases of typical infections common colds in the first 3 to 18 hours of the disease, a similar condition can be transmitted to man. With the unheated but not with the heated secretions from four of six such patients we have succeeded in transmitting an affection indistinguishable from common cold to four men and in two instances the condition was conveyed from the person with the experimental disease to a second individual -in all, therefore, to six supposedly normal subjects. The periods of incubation in the experimental disease varied from 8 to 48 hours. We failed to obtain these results with the filtered secretions from cases of common colds 18 and 20 hours after the onset of symptoms and from a patient with the experimental disease 20 hours after the first symptoms. It would appear that the secretions are more active in the early hours of the affection. We also failed in the two instances in ...
The relationship between cesarean section (CS) and allergic disorders such as asthma and wheezing has been inconsistent, and the mechanisms for their connection remained largely unknown. We aimed to investigate whether CS is associated with infantile wheeze and to explore the connection between CS and several risk factors known to correlate with allergy development. Mononuclear cells were isolated from cord blood and assessed for cytokine responses by ELISA. Bacteria from nasopharyngeal specimens were identified with traditional culture methods. Infant lung function tests were performed at 6 and 12 months of age. IgE levels and clinical outcomes were assessed at 12 months. The result showed that children delivered by CS were associated with increased risk of wheezing (aHR 1.63; 95% CI: 1.01-2.62) and decreased compliance of the respiratory system at 12 months (p = 0.045). In addition, CS was associated with reduced TLR1-2- triggered TNF-α and IL-6 responses at birth. By12 months of age, ...
The nasopharynx forms part of the pharynx, being the continuation of the nasal cavity superiorly, and the oropharynx inferiorly. Gross anatomy Boundaries anteriorly: posterior nares and posterior margin of nasal septum 1,2 inferiorly: soft p...
Expression of SPAG9 (CT89, FLJ13450, FLJ14006, FLJ26141, FLJ34602, HLC4, HSS, JIP-4, JIP4, JLP, KIAA0516, MGC117291, MGC14967, MGC74461, PHET, PIG6, SYD1) in nasopharynx tissue. Antibody staining with HPA040446 in immunohistochemistry.
Expression of TBC1D22B (C6orf197, dJ744I24.2, FLJ20337) in nasopharynx tissue. Antibody staining with HPA027908, HPA027909 and HPA027910 in immunohistochemistry.
The Annals of Nasopharynx Cancer publishes research articles on epidemiology, chemoprevention and screening, clinical management, translational and experimental research specific.
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A cancerous tumour of the nasopharynx can spread, or metastasize, to other parts of the body. Cancerous tumours are also called malignant tumours.
In the Netherlands, PCV-7 was implemented in the NIP at 2, 3, 4 and 11 months of age for all newborns, born after March 31, 2006 and the first vaccinations started in June 2006. The aim of the present study is to determine the impact of national PCV-7 implementation on NP pneumococcal carriage in children of 11 and 24 months of age and to evaluate NP colonization of one parent of a 24-month-old child. The 11 months time point, before the booster PCV-7 vaccination at 11 months of age, is chosen since the incidence of pneumococcal acquisition and IPD is the highest in the period of 4-11 months of age and changes in vaccine- and nonvaccine-serotype proportions at 11 months will result from both direct vaccine effects after the 3 primary PCV-7 doses and potentially also herd effects in the third year after the introduction of routine PCV-7. The time point of 24 months of age will reflect effects of PCV-7 vaccinations one year after the booster vaccination, as well as effects of the child s maturing ...
Background & Objectives: Respiratory-tract infections and invasive disease caused by Streptococcus pneumoniae (Spn) are a major cause of childhood deaths world...
Short-course, high-dose outpatient antibiotic therapy appears promising as an intervention to minimize the impact of antibiotic use on the spread of drug-resistant pneumococci.
BACKGROUND AND AIMS: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases consisting of more than 20 enzymes. MMP19 shares the typical MMP structural domains. It degrades various ECM components including collagen type IV, nidogen-1, fibronectin, tenascin-C isoform, aggrecan, and laminin-5-gamma-2-chain. In our previous studies, MMP19 was identified as a candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC). It was down-regulated in NPC cell lines and NPC biopsies, when compared to an immortalized normal nasopharyngeal epithelial cell line and corresponding non-tumor nasopharyngeal tissues. Transfection of wild-type (WT) MMP19 into the ...
Streptococcus is another kind of common bacteria of suppurative coccus, which exists in nature and human and animal excrement and healthy human nasopharynx, most of which are not pathogenic. The impor...
View Notes - Respiratory System rewrite from VS 441 at Becker College. RespiratorySystem VS441 Respiratorytract Upperrespiratorytract Lowerrespiratorytract Nasalpassages,sinuses
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NPak has designed and developed the most effective system for Nasopharyngeal Aspiration. Our Products provide a fast, efficient, and virtually painless way to collect specimens from the nasopharynx. The soft, self-guiding catheter is superior to nasal swabs in both sensitivity and comfort. NPak replaces the need for nasal washes, mucus traps and external suction - eliminating viral aerosilization. Our products have undergone rigorous testing to ensure quality, safety, and reliability.. ...
Zithromax is an antibiotic of the broad-spectrum action to treat bacterial infections of light or middle level of the severity. It acts against various bacteria especially Chlamydia, hemophilic bacteria and streptococcus. It may be taken for the treatment of the skin infections, infections of nasopharynx, lungs, and genitals.
A disease in which malignant cells form in the tissues of the nasopharynx, which is the upper part of the pharynx (throat) behind the nose.