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Subjects scored nasal congestion/stuffiness using an ordinal scale from 0 = none to 3 = severe. Baseline was the average of the scores assessed every 15 minutes for 1 hour prior to dosing on Day 1. After dosing on Day 1, congestion was scored every 15 minutes for the 1st hour and every 30 minutes for the next 3 hours. Area under the curve (AUC) was calculated using the trapezoid rule, then standardization achieved by dividing the calculation by 4 hours. Treatment comparisons were examined using the standardized AUC(0-4 hr) of the change from baseline to hour 4 on Day 1 ...
981 patients ⩾12 years of age (mean age 35 y, 66% women) with signs and symptoms of acute rhinosinusitis for ⩾7 days but ⩽28 days and major symptom score (MSS) ⩾5 but ⩽12, with ⩽3 of 5 symptoms rated as severe (based on the sum of scores for rhinorrhoea, postnasal drip, nasal congestion/stuffiness, sinus headache, and facial pain/pressure/tenderness).. ...
Efficacy and safety of fluticasone furoate nasal spray, administered using a unique side-actuated device, were evaluated in patients ≥12 years of age with seasonal allergic rhinitis to determine the optimal dose. A randomized, double-blind, parallel-group, placebo-controlled, dose-ranging study was performed on 641 patients who received placebo (n = 128) or fluticasone furoate, 55 g (n = 127), 110 g (n = 127), 220 g (n = 129), or 440 g (n = 130), once daily for 2 weeks. Fluticasone furoate was significantly more effective than placebo for mean changes from baseline over the 2-week treatment period in daily reflective total nasal symptom score (primary end point; p < 0.001 each dose vs. placebo), morning predose instantaneous total nasal symptom score (p < 0.001 each dose versus placebo), daily reflective total ocular symptom score (p ≤ 0.013 each dose versus placebo), and morning predose instantaneous total ocular symptom score (p ≤ 0.019 for three highest doses versus ...
This is an investigation in healthy subjects with early signs of common cold. Subjects will be randomly assigned in a 1:1 ratio to receive either Polymeric Nasal Spray or a matching placebo nasal spray.. Subjects will be screened for eligibility and randomized to treatment at the Screening/ Randomization Visit (Day 1). Subjects will apply the first dose of the nasal spray at this visit under supervision. The other applications will take place at home on Day 1. On Days 2 through 7, subjects will use their assigned nasal spray as 2 sprays per nostril, 4 times per day.. One Follow up Visit will be conducted within 3 days of the last application of nasal spray.. Enrollment will continue until 200 subjects have completed the investigation (100 per treatment group). The subject and the investigative staff will be blinded to the assigned nasal spray.. Efficacy will be measured, and recorded in the subjects diary, and safety will be assessed by reported AEs and ADEs. ...
It is widely accepted that nicotine replacement therapy can help patients to quit smoking. Recent approval by the US Food and Drug Administration of a nicotine nasal spray gives clinicians greater flexibility in choosing the best replacement therapy for a particular patient. Four types of smoking cessation therapy are currently available (gum, patch, nasal spray, and bupropion). These differ with respect to their onset and duration of action, adverse effects, and cost. This article focuses on which patients may benefit most from the use of nicotine nasal spray. Instructions for proper administration and dosing of the nicotine nasal spray are discussed as well as how to taper it appropriately, and how to avoid--and manage--adverse effects. Additionally, the cost of the nicotine nasal spray is reviewed and compared with over-the-counter products and bupropion. Resources for behavioral support are provided as well. ...
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Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis Friedrich HorakMedical University Vienna, ENT â Univ. Clinic, Vienna, AustriaAbstract: Azelastine nasal spray (Allergodil®, Lastin®, Afluon®; Meda AB, Stockholm, Sweden) is a fast-acting, efficacious and well-tolerated H1-receptor antagonist for the treatment of rhinitis. In addition it also has mast-cell stabilizing and anti-inflammatory properties, reducing the concentration of leukotrienes, kinins and platelet activating factor in vitro and in vivo, as well as inflammatory cell migration in rhinitis patients. Well-controlled studies in patients with seasonal allergic rhinitis (SAR), perennial rhinitis (PR) or vasomotor rhinitis (VMR) confirm that azelastine nasal spray has a rapid onset of action, and improves nasal symptoms associated with rhinitis such as nasal congestion and post-nasal drip. Azelastine nasal spray is effective at the lower dose of 1 spray as well at a dose of 2 sprays per
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Various statistical approaches are being used during the development of pharmaceutics. One of most powerful tools is Design of Experiments, which can be used to systematically study impact of factors on critical quality attributes (CQA).. Nasal sprays belong to a class of complex pharmaceutcial dosage forms, composed out of two major components: formulation (suspension) and delivery device (spray). One of key CQA for nasal sprays is geometry of a plume (spray pattern, cross-sectional profile), which is formed when nasal spray is actuated. Geometry of a plume defines area of dose deposition within nasal cavity (narrower spray pattern, longer projection, and vice versa).. With systematic analysis of factors and definition of significant ones, linear regression model can be build for, called also »Resposne surface model« . By applying factors of variability and uncertainty to the model using Monte Carlo simulations, one can perform Risk analysis and define optimal leveles of factors to achieve ...
Some people only need a nasal spray for the hay fever season (a few months). However, if you have a persistent rhinitis, you may have to take treatment long-term to keep symptoms away. Long-term use of a steroid nasal spray is thought to be safe.. Once symptoms are gone, you are still likely to need to use a steroid nasal spray regularly, to keep symptoms away. Your doctor may advise that you reduce the dose to a lower maintenance dose once symptoms have gone. The aim is to find the lowest dose that controls symptoms.. An occasional forgotten dose should not be a problem, but symptoms usually return after a few days if you stop taking the spray.. ...
MB12 Nasal Spray Summary. This is a DRAFT document - last updated 03/16/07 The Start of MB12 Nasal Spray and a Disclaimer MB12 Nasal Spray was developed by Stan Kurtz, an independent researcher and father of a child who recovered from autism.. Stan is also NOT A DOCTOR. He is a parent. Further more, many of the conclusions in this document come from parent observations and not scientific study. Several studies about MB12 are in various stages, but little is published to date.. This document is supported with medical literature, scientific data, clinical observation reports, and parental reports. It also reflects the observations, views and personal experience of Stan Kurtz who is a parent (not a doctor). Mr. Kurtzs perspective is driven from his personal experience including his own recovery from irritable bowel and ADHD symptoms. Additionally, it includes information from an evolving data pool of parents in his online group with 30,000 posts from 3000 members, many of which are sharing ...
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... , commonly known as Flonase nasal spray, works to control many symptoms of seasonal allergies. It works on the range of white blood cells that are put into action when an allergen is detected by the body. Since the reaction of the body to an allergen is what causes so much suffering, allergy medications such as Flixonase nasal spray work to keep this response under control.
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1. Durham SR, Yang WH, Pedersen MR, et al. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2006;117:802-809. 2. Dahl R, Kapp A, Colombo G, et al. Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2006;118:434-40 3. Smith H, White P, Annila I, et al. Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis. J Allergy Clin Immunol. 2004;114:831-837. 4. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2004;60:4-12. 5. Cox LS, Linnemann DL, Nolte H, et al. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol. 2006;117:1021-1035. 6. Passalacqua G, Pasquali M, Ariano R, et al. Randomized double-blind controlled study with sublingual carbamylated allergoid ...
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Single dose intranasal administration of 220 micrograms of Nasacort Allergy or Triamcinolone Nasal Spray in normal adult subjects and in adult patients with allergic rhinitis demonstrated minimal absorption of triamcinolone acetonide. The mean peak
You should stop smoking completely before using this nasal spray. Follow the directions carefully. Use exactly as directed. Blow nose gently to clear nasal passages. Tilt head back slightly and administer the prescribed amount of nasal spray. Do not sniff, swallow, or inhale through the nose as the spray is being given.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
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Cannabis industry is evolving rapidly and cannabis nasal sprays are just a part of the innovation that comes along with the evolution. Just as with many other methods of administering CBD, manufacturers are taking keen interest in making nasal sprays to get CBD into your body. This new method of administering CBD is safer and faster than most other methods and the combination of pharmaceutical-grade CBD and saline solution is excellent for treating various nasal allergies.. ...
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Nasal sprays are one common treatment. Nasal sprays work by distributing saline solution up into the sinus cavities. Nasal sprays are meant to moisten the cilia so that the trapped bacteria and mucus can be washed out. The problem with nasal sprays however is that they have large particle sizes that cannot make it past the inflammation at the opening of the sinus cavities and up to the sinusitis infection. Oral antibiotics and other oral medications are also frequently used treatments. Oral antibiotics work on infections by flowing through the blood stream to the infected area. Oral antibiotics are usually ineffective when it comes to sinusitis infections due to the fact that there are only a small amount of blood vessels in the sinus cavities which makes it difficult for an efficient amount of antibiotic, along with anti-fungals and anti-inflammatories, to make it to the sinus infection. Another treatment that may be used is irrigation. Irrigation, like nasal sprays, is meant to moisten the ...
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Nasal spray applicator, high-speed photograph. The spray visible here shows the release of the decongestant. In actual use, the tip of the spray applicator is placed inside the opening of one of the nostrils. - Stock Image C016/9644
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