Naphthalene produces species and cell selective injury to respiratory tract epithelial cells of rodents. In these studies we determined the apparent K{sub m}, V{sub max}, and catalytic efficiency (V{sub max}/K{sub m}) for naphthalene metabolism in microsomal preparations from subcompartments of the respiratory tract of rodents and non-human primates. In tissues with high substrate turnover, major metabolites were derived directly from naphthalene oxide with smaller amounts from conjugates of diol epoxide, diepoxide, and 1,2- and 1,4-naphthoquinones. In some tissues, different enzymes with dissimilar K{sub m} and V{sub max} appeared to metabolize naphthalene. The rank order of V{sub max} (rat olfactory epithelium , mouse olfactory epithelium , murine airways ≫ rat airways) correlated well with tissue susceptibility to naphthalene. The V{sub max} in monkey alveolar subcompartment was 2% that in rat nasal olfactory epithelium. Rates of metabolism in nasal compartments of the monkey were low. The ...
Parenteral administration of naphthalene produces a dose-dependent and tissue-, species-, and cell-selective lesion of murine Clara cells. The rate and stereoselectivity of naphthalene metabolism by microsomal preparations correlate with tissue and species differences in cytotoxicity. Because earlier studies used microsomes obtained from whole tissue, differences in susceptibility of proximal and distal airways could not be related to differences in the metabolic activation or detoxication of naphthalene. Specific subcompartments of the respiratory system, obtained by microdissection, have been used to study the cytochrome P450-dependent metabolism of naphthalene and the epoxide hydrolase/glutathione transferase-dependent metabolism of naphthalene oxide. The rates of naphthalene metabolism were substantially higher in mouse airways than in comparable airways of hamsters or rats. Rates of metabolism were higher in distal airways than in the trachea of all species studied. Metabolism in mouse ...
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Naphthalene is a type of polycyclic aromatic hydrocarbon (PAH) and possible carcinogen. It is found abundantly in outdoor air with traffic being the largest source. Elevated levels of naphthalene are also found in indoor air when mothballs or kitchen stoves burning biomass fuels are used.. Naphthalene is derived from petroleum and biofuel products and is found entirely in a gaseous phase rather than as a particulate. Human exposure to naphthalene is primarily through inhalation, although it can be ingested and absorbed through the skin. Due to the volatile nature of naphthalene, a box of mothballs can elevate indoor naphthalene levels to levels compatible with mid to upper level occupational exposure, with higher concentrations in smaller apartments or enclosed areas.. A cause of concern is that some Caribbean immigrant families in New York City frequently use mothballs as air fresheners. Therefore understanding potential downstream effects of naphthalene exposure has become increasingly ...
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TY - JOUR. T1 - Vapor-Liquid Equilibria in the System of Toluene/Aniline, Aniline/Naphthalene, and Naphthalene/Quinoline. AU - Lee, Chang-Ha. AU - Chen, Quen. AU - Mohamed, Rahoma S.. AU - Holder, Gerald D.. PY - 1992/4/1. Y1 - 1992/4/1. N2 - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately correlated with the modified Peng-Roblnson equation of state by using density-dependent mixing rules. The binary interaction parameters and correction factors for the equation of state are reported at each isotherm. The presence of coal-derived solids in these binary systems did not influence any of the binary bubble pressures.. AB - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately ...
ne),[[Vial (Naphthalene),Vial (Naphthalene)]]]] [[Vial (Naphthalene),Vial (Naphthalene)]] ...ory/Slot,index=4,title=Vial (Naphthalene),image=Vessel_vial.png,link=Vial (Naphthalene),amount=6}}{{Inventory/Slot,index=5,title=Vial (Benzene-Toluene-Xylene),ima ...
Exposure to naphthalene, 1-methylnaphthalene, or 2-methylnaphthalene happens mostly from breathing air contaminated from the burning of wood, tobacco, or fossil fuels, industrial discharges, or moth repellents. Exposure to large amounts of naphthalene may damage or destroy some of your red blood cells. Naphthalene has caused cancer in animals. Naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene have been found in at least 647, 37, and 410, respectively, of the 1,636 National Priority List sites identified by the Environmental Protection Agency (EPA).
Naphthalene is a commonly-occurring, volatile, polycyclic aromatic hydrocarbon, entering the environment from combustion processes, industrial uses, and consumer products (mothballs, cigarette smoke, etc.). Non-cancer air guidance Health-Based Values (HBV) were derived for naphthalene by MDH in 2004 for the acute (200 µg/m3) and chronic (9 µg/m3) durations. However, a cancer HBV has not been established. Possible carcinogenic concerns from inhalation of naphthalene have been an ongoing debate within the scientific community for nearly two decades (U. S. Environmental Protection Agency (EPA), 1998). The applicability of rodent respiratory (nasal/lung) tumors for deriving quantitative human health risk values is the critical outstanding issue.. The EPAs Integrated Risk Information System (IRIS) program evaluated naphthalene in 1998, 2004 (never completed), and is currently in the Draft Development stage for another update initiated in 2014. No estimate of naphthalene cancer potency, ...
3) United States Edition of Industrial Naphthalene Market Report 2020. Global Coronavirus pandemic has impacted all industries across the globe, Industrial Naphthalene market being no exception. As the Global economy heads towards major recession post-2009 crisis, Cognitive Market Research has published a recent study which meticulously studies the impact of this crisis on Global Industrial Naphthalene market and suggests possible measures to curtail them. This press release is a snapshot of the research study and further information can be gathered by accessing a complete report.To Contact Research experts Mail us @ [email protected] or call us on +1-312-376-8303.. Download Report Preview from here: https://www.cognitivemarketresearch.com/chemical-%26-materials/industrial-naphthalene-market-report#download_report The research team of Cognitive Market Research has formulated and compiled a new research report on Industrial Naphthalene market. The Industrial Naphthalene research report contains ...
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article{2003590, abstract = {During lung development, parabronchial SMC (PSMC) progenitors in the distal mesenchyme secrete fibroblast growth factor 10 (Fgf10), which acts on distal epithelial progenitors to promote their proliferation. beta-catenin signaling within PSMC progenitors is essential for their maintenance, proliferation, and expression of Fgf10. Here, we report that this Wnt/Fgf10 embryonic signaling cascade is reactivated in mature PSMCs after naphthalene-induced injury to airway epithelium. Furthermore, we found that this paracrine Fgf10 action was essential for activating surviving variant Clara cells (the cells in the airway epithelium from which replacement epithelial cells originate) located at the bronchoalveolar duct junctions and adjacent to neuroendocrine bodies. After naphthalene injury, PSMCs secreted Fgf10 to activate Notch signaling and induce Snail expression in surviving variant Clara cells, which subsequently underwent a transient epithelial to mesenchymal transition ...
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to 32.33 C .Find Erxn for the combustion of naphthalene. The heat capacity of the calorimeter, determined in separate experiment, is 5.211kJ/Celsius. .button {
Mothballs in households arent as widespread since they used to be, but when you have these small orbs of pesticides, try to be aware of the risks they current. The key ingredient in mothballs is naphthalene, which triggers a breakdown of pink blood cells in children that has hop over to these guys a genetic affliction referred to as G6PD deficiency, and pediatricians in Australian identified as for just a ban on naphthalene following it absolutely was associated with one particular babys death and brain hurt in two Other folks ...
Having examined the absorption spectra of naphthalene and its methyl derivatives, I have continued the investigation in order to see how the spectrum of naphthalene is affected by the introduction of different groups in the alpha and beta positions. The technique employed for the solution and vapour spectra has been fully described elsewhere. Pure hexane§ was used as a solvent unless otherwise stated, ϵ is the molecular absorption coefficient. The substances were purified by crystallisation from hexane. Liquids were fractionally distilled in vacuo. ...
ZrO2 nH2O (hydrogel) impregnated with transition metals (Cu, Co, and Ni) was studied in this work as a precursor for the synthesis of CuO/ZrO2 (CuZ), CoOx/ZrO2 (CoZ), and NiO/ZrO2 (NiZ) catalysts, employed in the naphthalene oxidation reaction. Fresh and catalytically used materials were characterized by different physicochemical techniques, to compare the bulk and surface behavior, with particular attention to the effect of the supported metal species properties on the catalytic activity. Techniques such as X-ray diffraction (XRD), temperature programmed reduction (TPR), differential scanning calorimetry (DSC), Brunauer-Emmett-Teller (BET) surface area analyzer, diffuse reflectance spectroscopy (DRS UV-vis), and Raman spectroscopy, allow for establishing structural and textural aspects of the support, as well as the surface coordination and the accessibility of supported species. Results were in agreement with the CuZ > CoZ > NiZ sequence for the activity in naphthalene oxidation reaction.
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This with my own letter gave me a very happy Atlantic crossing. I arrived in time to see Bragg on the 23rd. He told me that Jenkinson was making two new cameras, one of which was assigned to me. It would have a single circle goniometer head! He suggested that I work on the phenyl aliphatic acids as a tie in between his work on naphthalene and anthracene, and the work Muller and Shearer were doing on long chain compounds. He then told me to go take a good long holiday, possibly to read the two volumes of Tutton, and follow them by Hilton so that I would be ready to read the new paper by Astbury and Yardley on space-groups when I came back in September. I did read Tutton, but Hilton and the paper took the best part of the next year.. When I returned in September I set out to build my own X-ray equipment. The tube was a gas tube designed by Shearer and was built in the shop. The pumps were of local design and I was told that when I had made one in soft glass, I would be given some of a very ...
Applying complex ARENA BiMix NS/PC additive in the course of preparation of concrete, it is possible to increase significantly durability and to improve other qualitative indexes of concrete mixes, including parameters of mobility, speed of curing and water tightness. Active mineral fillers and a complex of the innovation polymeric modifiers are a part of the additive executed on the basis of microcement in ARENA BiMix NS/PC concrete. This additive should be entered into concrete solutions, proceeding from regulation of 3-6% to the mass of cement. For determination of an optimum dosage of ARENA BiMix NS/PC additive at production of concrete of various structure it is recommended to execute a series of trial batches.. ARENA BiMix NS is compatible with additives to concrete on naphthalene sulfate base ...
Naphthalene, 1,1-diethoxy-1,2,3,4-tetrahydro- | C14H20O2 | CID 71387374 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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TY - GEN. T1 - Isolation and characterisation of naphthalene utilising microorganisms.. AU - Singh - Nee Nigam, Poonam. PY - 1995/8. Y1 - 1995/8. M3 - Conference contribution. SP - 114. EP - 114. BT - Unknown Host Publication. PB - University of Copenhagen. T2 - Global Impacts of Applied Microbiology & Biotechnology, 5 12 August,1995, ,. Y2 - 1 August 1995. ER - ...
TY - GEN. T1 - Isolation and characterisation of naphthalene utilising microorganisms. AU - Singh - Nee Nigam, Poonam. PY - 1994/3/28. Y1 - 1994/3/28. M3 - Conference contribution. BT - Unknown Host Publication. PB - Ulster University. T2 - Biotechnology and Industry: Present and Future, University of Ulster, UK,. Y2 - 28 March 1994. ER - ...
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In 1890, chemists had to work hard to find out what the structures of their molecules were, given they had no access to the plethora of modern techniques we are used to in 2010. For example, how could they be sure what the structure of naphthalene was? Well, two such chemists, William Henry Armstrong (1847-1937) and his student William Palmer Wynne (1861-1950; I might note that despite working with toxic chemicals for years, both made it to the ripe old age of ~90!) set out on an epic 11-year journey to synthesize all possible mono, di, tri and tetra-substituted naphthalenes. Tabulating how many isomers they could make (we will call them AW here) would establish beyond doubt the basic connectivity of the naphthalene ring system. This was in fact very important, since many industrial dyes were based on this ring system, and patents depended on getting it correct! Amazingly, their collection of naphthalenes survives to this day. With the passage of 120 years, we can go back and check their ...
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SAN DIEGO, Nov. 15 -- Amgen (Nasdaq: AMGN), the worlds largest biotechnology company, announced results of phase 3 studies evaluating the efficacy and safety of cinacalcet HCl, a first-in-class oral calcimimetic, administered once daily for the treatment of secondary hyperparathyroidism (HPT) associated with chronic kidney disease (CKD). These results were presented at an American Society of Nephrology (ASN) sponsored symposium in San Diego.. Amgen recently received notification that the U.S. Food and Drug Administration (FDA) granted a priority review for cinacalcet HCl, a novel therapeutic that modulates the activity of the calcium-sensing receptor, the primary regulator of PTH secretion. Cinacalcet HCl is the first investigational agent to demonstrate simultaneous reductions in parathyroid hormone (PTH), calcium-phosphorus product, phosphorus and calcium levels to successfully control secondary HPT. Moreover, cinacalcet HCl may allow patients to achieve PTH and mineral targets in accordance ...
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Naphthalene is a white solid that evaporates easily. Fuels such as petroleum and coal contain naphthalene. It is also called white tar, and tar camphor, and has been used in mothballs and moth flakes. Burning tobacco or wood produces naphthalene. It has a strong, but not unpleasant smell. The major commercial use of naphthalene is in the manufacture of polyvinyl chloride (PVC) plastics. Its major consumer use is in moth repellents and toilet deodorant blocks. 1-Methylnaphthalene and 2-methylnaphthalene are naphthalene-related compounds. 1-Methylnaphthalene is a clear liquid and 2-methylnaphthalene is a solid; both can be smelled in air and in water at very low concentrations. 1-Methylnaphthalene and 2-methylnaphthalene are used to make other chemicals such as dyes and resins. 2-Methylnaphthalene is also used to make vitamin K.
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Name:4-(Phenyldiazenyl)naphthalen-1-amine CA Name: 1-Naphthalenamine,4-(phenylazo)- Molecular Structure: 4-(Phenyldiazenyl)naphthalen-1-amine,1-Naphthalenamine,4-(phenylazo)-,CAS 131-22-6,247.29,C16H13N3 4-(Phenyldiazenyl)naphthalen-1-amine,1-Naphthalenamine,4-(phenylazo)-,CAS 131-22-6,247.29,C16H13N3 Molecular Formula:C16H13N3 Molecular Weight: 247.29 CAS Registry Number: 131-22-6
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Preparations for the study of naphthalene diffusion dissolved in the supercritical fluids carbon dioxide and ethylene have proceeded as follows. We plan to use the fixed field gradient NMR technique to monitor the diffusion of the dissolved naphthalene. However, the technique is not feasible in systems with spin-spin coupling among the nuclei of interest; unfortunately the protons on naphthalene exhibit this coupling. We thus intend to use totally deuterated naphthalene and monitor the deuterium signal, a nucleus whose coupling is negligible. We therefore have designed and built a new high pressure NMR probe for the measurement of deuterium. This probe is similar to the one used in the previous naphthalene solubility study, and accommodates the same supercritical sample cells. The probe is machined from Vespel SP-1 (a high temperature plastic), and houses a 17-1/2 turn solenoid NMR coil along with thermocouples located slightly above and below the sample area. The probe has been successfully tested to 2
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Systematic (IUPAC) name 1-[(5-fluoropentyl)-6-nitro-1H-indol-3-yl]-(naphthalen-1-yl)methanone Clinical data Pregnancy cat. ? Legal status ? Identifiers CAS number Yes ATC code ? ChemSpider 26633899 Chemical data Formula C24H21FN2O3 Mol. .....
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1-phenyl-3-dimethylamino-6-chloro-7-hydroxy-1,2,3,4-tetrahydronaphthalene: RN refers to (trans)-isomer; a phenylaminotetralin; structure given in first source
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The fibronectin content of RMC cultures grown for 8-14 days in medium containing 30 mM (540 mg/dl) D-glucose was increased 30-60% relative to that of control cells cultured in 10 mM (180 mg/dl) glucose. Addition of equiosmolar concentrations (20 mM, 360 mg/dl) of L-glucose, 3-O-methylglucose, or mannitol to 10 mM glucose media did not alter fibronectin accumulation compared with values observed in 10 mM glucose alone. The basal phosphorylation of the 80,000-Mr MARCKS protein, which is a substrate for PKC, and the phosphorylation induced by acute (15-min) exposure of cells to 15% FCS or to 0.1 μM (50 ng/ml) PDBu were all increased in cells grown in 30 mM compared with 10 mM glucose. By contrast, phosphorylation of the 80,000-Mr protein in response to a maximal concentration of PDBu (1 μM, 500 ng/ml) was not different in cells grown in 30 mM compared with 10 mM glucose. The acute increases in phosphorylation of the 80,000-Mr protein were blocked by the PKC inhibitor calphostin C. Chronic (7-day) ...
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Remediation goal: final concentration BTEX 0,2/7,0/4,0/0,2 ug/l Mineral oil ,50 ug/l Naphthalene Remediation goal achieved?: No, as a result of the layered soil profile part of the contamination remained. Initial and final concentration and load removal: BTEX total initial concentration: max. 51300 ug/l; initial concentration: max. 6,1 ug/l Mineral oil initial concentration: max. 5300; final concentration: max. 157 (once-only, remain ,50) Naphthalene initial concentration: max. 470 ug/l; final concentration: max. 1,1 ug/l Active remediation phase: 01-04-99 until 01-04-08 Passive remediation phase: The phase is not yet completed. Total costs passive/after care phase: Total costs active phase: ...
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